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SRX1036433: GSM1693900: ChIP_E2F1_hTERT-RPE1; Homo sapiens; ChIP-Seq
1 ILLUMINA (Illumina Genome Analyzer IIx) run: 28.4M spots, 851.5M bases, 274Mb downloads

Submitted by: NCBI (GEO)
Study: Histone genes transcription regulators binding in human cancer (U2OS) and normal (hTERT-RPE1) cells
show Abstracthide Abstract
The regulation of replication-dependent histone genes by CASP8AP2 and NPAT is likely direct, based on ChIP-seq. CASP8AP2 and NPAT ChIP-Seq peaks were enriched near transcription start sites (TSSs) of replication-dependent, but not replication-independent histone genes on chromosomes 1, 6 and 12 in both cell lines. HINFP ChIP-Seq peaks were enriched near transcription start sites (TSSs) of replication-dependent histone genes H4 and H2B and replication-independent histone genes H1FX and H1F0 in both cell lines. Another histone gene regulator, E2F1 also bound to TSSs of many histone genes mainly replication-independent. Overall design: Examination of histone genes transcroption regulators binding by ChIP-seq in normal and cancer cell lines
Sample: ChIP_E2F1_hTERT-RPE1
SAMN03704236 • SRS943590 • All experiments • All runs
Organism: Homo sapiens
Library:
Instrument: Illumina Genome Analyzer IIx
Strategy: ChIP-Seq
Source: GENOMIC
Selection: ChIP
Layout: SINGLE
Construction protocol: Cells were cross-linked by 1% formaldehyde, and DNA was sonicated to 200- 400 bp fragments. Antibodies (5 µg) were added and collected using protein G Sepharose (GE). Cross-links were reversed and proteins digested by incubation with proteinase K at 65 °C overnight. DNA was then purified using Qiagen PCR purification kit. Libraries were constructed according to Illuminas standard protocol.
Links:
Runs: 1 run, 28.4M spots, 851.5M bases, 274Mb
Run# of Spots# of BasesSizePublished
SRR203701528,382,676851.5M274Mb2017-05-18

ID:
1500024

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