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ERX3939153: Illumina HiSeq 2500 paired end sequencing
1 ILLUMINA (Illumina HiSeq 2500) run: 1.1M spots, 270.2M bases, 87.6Mb downloads

Design: Illumina sequencing of library DN495211L:E2, constructed from sample accession ERS4308695 for study accession ERP024475. This is part of an Illumina multiplexed sequencing run (24022_1). This submission includes reads tagged with the sequence TGGTTGTT.
Submitted by: Wellcome Sanger Institute
Study: Global_phylogenetic_analysis_of_the_health_promoting_genus_Bifidobacterium
show Abstracthide Abstract
Background: The bond with our microbiota starts at birth and has co-evolved where fitness of the two participants has become interdependent. Recent comprehensive analysis of the infant microbiota indicates that the family Bifidobacteriaceae is dominant (~80%), compared with approx. 10% for the phylum Firmicutes. Importantly, high levels of bifidobacteria in the infant gut have been associated with the timely development and maturation of mucosal immunity and reduced infection rates. Members of this genus have been used in a wide variety of studies to promote health and as probiotics, however the mechanisms behind these events are as yet not fully characterised. Bifidobacteria are Gram-positive, anaerobic, non-spore forming, non-motile, non-filamentous rods with high G+C content belonging to the phylum Actinobacteria. Indeed, Bifidobacterium represents one of the largest genus within the Actinobacteria, and includes at present 51 species. In the context of early life, bifidobacteria are also found within breast milk, and these strains have enzymes capable of metabolising milk oligosaccharides, enabling growth and persistence, suggesting co-evolution of bacteria-host and diet. Bifidobacteria have also been extensively detected in the gut of mammals, birds and social insects. Due to their associated health benefits, there is significant need to explore the diversity of the bifidobacterial population at a global level and within individuals. Although the genetic diversity of Bifidobacterium has been determined based on several marker genes or a relatively small number of genomes, the global diversity and evolution scenario for the entire genus remain unresolved.
Sample: BIF_WGS7035352
SAMEA6544320 • ERS4308695 • All experiments • All runs
Library:
Name: DN495211L:E2
Instrument: Illumina HiSeq 2500
Strategy: WGS
Source: GENOMIC
Selection: RANDOM
Layout: PAIRED
Construction protocol: Standard
Runs: 1 run, 1.1M spots, 270.2M bases, 87.6Mb
Run# of Spots# of BasesSizePublished
ERR39315631,080,954270.2M87.6Mb2020-02-25

ID:
10187391

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