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SRX014075: Whole Genome Sequencing of human
3 ILLUMINA (Illumina Genome Analyzer) runs: 43.3M spots, 1.6G bases, 1.2Gb downloads

Design: 36-cycle Solexa sequencing of sample SA_1
Submitted by: Cancer Research UK (CRUK) (CRI)
Study: Co-operative interaction between Retinoic Acid Receptor-a and Estrogen Receptor in breast cancer
show Abstracthide Abstract
Retinoic Acid Receptor-a (RARa) is a known estrogen target gene in breast cancer cells. The consequence of RARa induction by estrogen was previously unknown. We now show that RARa is required for efficient Estrogen Receptor-a (ER)-mediated transcription and cell proliferation. RARa can interact with ER binding regions, but this occurs in an ER-dependent manner, providing a novel role for RARa that is independent of its classic role. We show, on a genome-wide scale, that RARa and ER can co-occupy regulatory regions together within the chromatin. This transcriptionally active co-occupancy and dependency occurs when exposed to the predominant breast cancer hormone, estrogen; an interaction that is promoted by the estrogen-ER induction of RARa. These findings implicate RARa as an essential component of the ER complex, potentially by maintaining ER-co-factor interactions and suggest that different nuclear receptors can co-operate for effective transcriptional activity in breast cancer cells.
Sample: Generic sample from Homo sapiens
SAMN00006187 • SRS008315 • All experiments • All runs
Organism: Homo sapiens
Name: jc03
Instrument: Illumina Genome Analyzer
Strategy: ChIP-Seq
Selection: ChIP
Layout: SINGLE
Spot descriptor:

Runs: 3 runs, 43.3M spots, 1.6G bases, 1.2Gb
Run# of Spots# of BasesSizePublished


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