U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SRX368804: GSM1252086: col RNA-seq; Arabidopsis thaliana; RNA-Seq
1 ILLUMINA (Illumina HiSeq 2000) run: 25.8M spots, 4.6G bases, 3Gb downloads

Submitted by: Gene Expression Omnibus (GEO)
Study: Arabidopsis EDM2 Promotes IBM1 Distal Polyadenylation and Regulates Genome DNA Methylation Patterns [RNA-Seq]
show Abstracthide Abstract
A forward genetics screen led to the identification of the putative chromatin regulator EDM2 as a cellular anti-silencing factor and regulator of genome DNA methylation patterns. EDM2 contains a composite PHD finger domain that recognizes both active H3K4 and repressive H3K9 methylation marks at the intronic repeat elements in genes such as the histone H3K9 demethylase gene IBM1, and is necessary for maintaining the expression of these genes by promoting mRNA distal polyadenylation. Because of its role in maintaining IBM1 expression, EDM2 is required for preventing CHG methylation in the bodies of thousands of genes.Our results thus increase the understanding of anti-silencing, genome methylation patterns, and regulation of alternative RNA processing by intronic heterochromatin. Overall design: Col-0 and edm2-4 total RNA are extracted from leaves and then polyA mRNAs are isolated for mRNA-seq.
Sample: col RNA-seq
SAMN02384877 • SRS494447 • All experiments • All runs
Library:
Instrument: Illumina HiSeq 2000
Strategy: RNA-Seq
Source: TRANSCRIPTOMIC
Selection: cDNA
Layout: PAIRED
Construction protocol: RNA was extracted with Trizol reagent from 14-d Arabidopsis leaves, followed by clean-up and DNase I treatment with QIAGEN RNeasy mini kit in accordance with the prescribed protocol provided with the kit. Quality control was performed with Agilent Bioanalyser. The extracted RNA was sent to BGI (Shenzhen, China) for RNA-seq library preparation and whole transcriptome sequencing. Briefly, The total RNA was treated with DNaseI and then subjected for mRNA enrichment. The derived mRNA was used as the template for first strand cDNA synthesis by using oligo dT primer. The adaptor was added to the 5’ end of the first strand cDNA and then the second strand cDNA was synthesized by using the primer pairing to the adaptor. The double strand cDNA was sonicated into 300-500 bp fragments for pair-ended sequencing with HiSeq 2000.
Experiment attributes:
GEO Accession: GSM1252086
Links:
External link:
Runs: 1 run, 25.8M spots, 4.6G bases, 3Gb
Run# of Spots# of BasesSizePublished
SRR101922125,800,3064.6G3Gb2015-07-22

ID:
527486

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...