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ERX294570: Population Genomics of human gut metagenome
1 ILLUMINA (Illumina HiSeq 2000) run: 30.6M spots, 5.5G bases, 3.4Gb downloads

Submitted by: Beijing Genome Institute (BGI)
Study: Richness of human gut microbiome correlates with metabolic markers
show Abstracthide Abstract
We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They harbour known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the former also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
Sample: MetaHIT-MH0131
SAMEA2159102 • ERS328844 • All experiments • All runs
Library:
Name: 101101
Instrument: Illumina HiSeq 2000
Strategy: WGS
Source: METAGENOMIC
Selection: other
Layout: PAIRED
Spot descriptor:
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Runs: 1 run, 30.6M spots, 5.5G bases, 3.4Gb
Run# of Spots# of BasesSizePublished
ERR32143730,580,2155.5G3.4Gb2013-09-18

ID:
496073

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