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ERX380638: Illumina HiSeq 2000 paired end sequencing
1 ILLUMINA (Illumina HiSeq 2000) run: 34.3M spots, 5.7G bases, 3.9Gb downloads

Submitted by: Beijing Genome Institute (BGI)
Study: An integrated catalog of reference genes in the human gut microbiome
show Abstracthide Abstract
The gut microbiota is key to human health and disease. Metagenome-wide association studies (MGWAS) that search for disease markers in the gut microbiota, species identification according to metagenomic linkage groups (MLGs) or metagenomic clusters (MGCs), and metatranscriptomics or metaproteomics studies, all depend on a reference gene catalog, which has only been available for individual cohorts or based on reference genome or protein sequences. Here we report a high-quality integrated reference gene catalog consisting 9,879,896 genes, using 6.4 TB sequencing data derived from 1267 published and unpublished human gut metagenomes from three continents. The catalog represents a comprehensive collection of common and rare species, genes and genetic variants, and suggests individuality in the human gut microbiota. Analyses of a group of Chinese and Danish samples using the catalog revealed country-specific signatures in nutrient and xenobiotic metabolism. Our data suggest that interventions on nutrition, pollution and epidemiology should be tailored to the gut microbiota of a given population or even personalized for an individual.
Sample: Stool sample from danish
SAMEA2338716 • ERS396386 • All experiments • All runs
Name: 101009
Instrument: Illumina HiSeq 2000
Strategy: WGS
Selection: other
Layout: PAIRED
Spot descriptor:
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Runs: 1 run, 34.3M spots, 5.7G bases, 3.9Gb
Run# of Spots# of BasesSizePublished


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