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DRX038278: Ion Torrent Proton sequencing of SAMD00036332
1 ION_TORRENT (Ion Torrent Proton) run: 1.1M spots, 195.6M bases, 143.3Mb downloads

Submitted by: UT_COB
Study: Metagenomics of Japanese gut microbiomes
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The human gut microbiome has profound influences on the host’s health largely through its inter- ference with various intestinal functions. As recent studies have suggested diversity in the human gut microbiome among human populations, it will be interesting to analyse how gut microbiome is correlated with geographical, cultural, and traditional differences. The Japanese people are known to have several characteristic features such as eating a variety of traditional foods and exhibit- ing a low BMI and long life span. In this study, we analysed gut microbiomes of the Japanese by com- paring the metagenomic data obtained from 106 Japanese individuals with those from 11 other nations. We found that the composition of the Japanese gut microbiome showed more abundant in the phylum Actinobacteria, in particular in the genus Bifidobacterium, than other nations. Regard- ing the microbial functions, those of carbohydrate metabolism were overrepresented with a concur- rent decrease in those for replication and repair, and cell motility. The remarkable low prevalence of genes for methanogenesis with a significant depletion of the archaeon Methanobrevibacter smithii and en- richment of acetogenesis genes in the Japanese gut microbiome compared with others suggested a difference in the hydrogen metabolism pathway in the gut between them. It thus seems that the gut microbiome of the Japanese is considerably different from those of other populations, which cannot be simply explained by diet alone. We postulate possible existence of hitherto unknown factors contributing to the population-level diversity in human gut microbiomes.
Sample: FTAG20-m80c-Fast
SAMD00036332 • DRS026533 • All experiments • All runs
Instrument: Ion Torrent Proton
Strategy: WGS
Selection: RANDOM
Layout: SINGLE
Construction protocol:
Spot descriptor:

Runs: 1 run, 1.1M spots, 195.6M bases, 143.3Mb
Run# of Spots# of BasesSizePublished


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