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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs7412

Current Build 154

Released April 21, 2020

Organism
Homo sapiens
Position
chr19:44908822 (GRCh38.p12) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
C>T
Variation Type
SNV Single Nucleotide Variation
Frequency
T=0.061504 (8425/136984, GnomAD_exome)
T=0.086501 (10945/126530, ALFA Project)
T=0.082139 (10314/125568, TOPMED) (+ 14 more)
T=0.08268 (2571/31094, GnomAD)
T=0.07182 (972/13534, ExAC)
T=0.0751 (376/5008, 1000G)
T=0.1009 (452/4480, Estonian)
T=0.0924 (356/3854, ALSPAC)
T=0.0917 (340/3708, TWINSUK)
T=0.0693 (200/2888, KOREAN)
T=0.0720 (97/1348, HapMap)
T=0.082 (49/600, NorthernSweden)
T=0.014 (3/216, Qatari)
C=0.45 (29/64, SGDP_PRJ)
T=0.20 (8/40, GENOME_DK)
C=0.5 (4/8, Siberian)
T=0.5 (4/8, Siberian)
Clinical Significance
Reported in ClinVar
Gene : Consequence
APOE : Missense Variant
Publications
360 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p12 chr 19 NC_000019.10:g.44908822C>T
GRCh37.p13 chr 19 NC_000019.9:g.45412079C>T
APOE RefSeqGene NG_007084.2:g.8041C>T
Gene: APOE, apolipoprotein E (plus strand)
Molecule type Change Amino acid[Codon] SO Term
APOE transcript variant 4 NM_001302690.1:c.526C>T R [CGC] > C [TGC] Coding Sequence Variant
apolipoprotein E isoform b precursor NP_001289619.1:p.Arg176Cys R (Arg) > C (Cys) Missense Variant
APOE transcript variant 2 NM_000041.4:c.526C>T R [CGC] > C [TGC] Coding Sequence Variant
apolipoprotein E isoform b precursor NP_000032.1:p.Arg176Cys R (Arg) > C (Cys) Missense Variant
APOE transcript variant 3 NM_001302689.2:c.526C>T R [CGC] > C [TGC] Coding Sequence Variant
apolipoprotein E isoform b precursor NP_001289618.1:p.Arg176Cys R (Arg) > C (Cys) Missense Variant
APOE transcript variant 1 NM_001302688.2:c.604C>T R [CGC] > C [TGC] Coding Sequence Variant
apolipoprotein E isoform a precursor NP_001289617.1:p.Arg202Cys R (Arg) > C (Cys) Missense Variant
APOE transcript variant 5 NM_001302691.2:c.526C>T R [CGC] > C [TGC] Coding Sequence Variant
apolipoprotein E isoform b precursor NP_001289620.1:p.Arg176Cys R (Arg) > C (Cys) Missense Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: T (allele ID: 32887 )
ClinVar Accession Disease Names Clinical Significance
RCV000019428.30 Familial type 3 hyperlipoproteinemia Pathogenic
RCV000019439.29 Apolipoproteinemia E1 Pathogenic
RCV000019452.30 Familial type 3 hyperlipoproteinemia Pathogenic
RCV000019454.30 Familial type 3 hyperlipoproteinemia Pathogenic
RCV000211178.1 atorvastatin response - Efficacy Drug-Response
RCV000346955.2 not provided Other,Risk-Factor
RCV000825286.1 not specified Uncertain-Significance
RCV000845582.1 Warfarin response Drug-Response

ALFA Allele Frequency (New)
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20200227123210
Population Group Sample Size Ref Allele Alt Allele
Total Global 126530 C=0.913499 T=0.086501
European Sub 114152 C=0.913177 T=0.086823
African Sub 3266 C=0.9036 T=0.0964
African Others Sub 104 C=0.894 T=0.106
African American Sub 3162 C=0.9039 T=0.0961
Asian Sub 150 C=0.913 T=0.087
East Asian Sub 88 C=0.93 T=0.07
Other Asian Sub 62 C=0.89 T=0.11
Latin American 1 Sub 340 C=0.921 T=0.079
Latin American 2 Sub 28 C=0.96 T=0.04
South Asian Sub 58 C=1.00 T=0.00
Other Sub 8536 C=0.9206 T=0.0794


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
gnomAD - Exomes Global Study-wide 136984 C=0.938496 T=0.061504
gnomAD - Exomes European Sub 59780 C=0.92847 T=0.07153
gnomAD - Exomes Asian Sub 33656 C=0.94750 T=0.05250
gnomAD - Exomes American Sub 24704 C=0.96883 T=0.03117
gnomAD - Exomes Ashkenazi Jewish Sub 8126 C=0.9203 T=0.0797
gnomAD - Exomes African Sub 6624 C=0.8921 T=0.1079
gnomAD - Exomes Other Sub 4094 C=0.9392 T=0.0608
ALFA Total Global 126530 C=0.913499 T=0.086501
ALFA European Sub 114152 C=0.913177 T=0.086823
ALFA Other Sub 8536 C=0.9206 T=0.0794
ALFA African Sub 3266 C=0.9036 T=0.0964
ALFA Latin American 1 Sub 340 C=0.921 T=0.079
ALFA Asian Sub 150 C=0.913 T=0.087
ALFA South Asian Sub 58 C=1.00 T=0.00
ALFA Latin American 2 Sub 28 C=0.96 T=0.04
TopMed Global Study-wide 125568 C=0.917861 T=0.082139
gnomAD - Genomes Global Study-wide 31094 C=0.91732 T=0.08268
gnomAD - Genomes European Sub 18716 C=0.92530 T=0.07470
gnomAD - Genomes African Sub 8640 C=0.8939 T=0.1061
gnomAD - Genomes East Asian Sub 1556 C=0.9184 T=0.0816
gnomAD - Genomes Other Sub 1080 C=0.9269 T=0.0731
gnomAD - Genomes American Sub 818 C=0.958 T=0.042
gnomAD - Genomes Ashkenazi Jewish Sub 284 C=0.944 T=0.056
ExAC Global Study-wide 13534 C=0.92818 T=0.07182
ExAC Asian Sub 7974 C=0.9545 T=0.0455
ExAC Europe Sub 4754 C=0.8944 T=0.1056
ExAC African Sub 460 C=0.815 T=0.185
ExAC American Sub 204 C=0.961 T=0.039
ExAC Other Sub 142 C=0.901 T=0.099
1000Genomes Global Study-wide 5008 C=0.9249 T=0.0751
1000Genomes African Sub 1322 C=0.8971 T=0.1029
1000Genomes East Asian Sub 1008 C=0.8998 T=0.1002
1000Genomes Europe Sub 1006 C=0.9374 T=0.0626
1000Genomes South Asian Sub 978 C=0.956 T=0.044
1000Genomes American Sub 694 C=0.952 T=0.048
Genetic variation in the Estonian population Estonian Study-wide 4480 C=0.8991 T=0.1009
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 C=0.9076 T=0.0924
UK 10K study - Twins TWIN COHORT Study-wide 3708 C=0.9083 T=0.0917
KOREAN population from KRGDB KOREAN Study-wide 2888 C=0.9307 T=0.0693
HapMap Global Study-wide 1348 C=0.9280 T=0.0720
HapMap American Sub 536 C=0.924 T=0.076
HapMap African Sub 392 C=0.923 T=0.077
HapMap Asian Sub 250 C=0.924 T=0.076
HapMap Europe Sub 170 C=0.959 T=0.041
Northern Sweden ACPOP Study-wide 600 C=0.918 T=0.082
Qatari Global Study-wide 216 C=0.986 T=0.014
SGDP_PRJ Global Study-wide 64 C=0.45 T=0.55
The Danish reference pan genome Danish Study-wide 40 C=0.80 T=0.20
Siberian Global Study-wide 8 C=0.5 T=0.5
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement C= T
GRCh38.p12 chr 19 NC_000019.10:g.44908822= NC_000019.10:g.44908822C>T
GRCh37.p13 chr 19 NC_000019.9:g.45412079= NC_000019.9:g.45412079C>T
APOE RefSeqGene NG_007084.2:g.8041= NG_007084.2:g.8041C>T
APOE transcript variant 2 NM_000041.4:c.526= NM_000041.4:c.526C>T
APOE transcript variant 2 NM_000041.3:c.526= NM_000041.3:c.526C>T
APOE transcript NM_000041.2:c.526= NM_000041.2:c.526C>T
APOE transcript variant 1 NM_001302688.2:c.604= NM_001302688.2:c.604C>T
APOE transcript variant 1 NM_001302688.1:c.604= NM_001302688.1:c.604C>T
APOE transcript variant 5 NM_001302691.2:c.526= NM_001302691.2:c.526C>T
APOE transcript variant 5 NM_001302691.1:c.526= NM_001302691.1:c.526C>T
APOE transcript variant 3 NM_001302689.2:c.526= NM_001302689.2:c.526C>T
APOE transcript variant 3 NM_001302689.1:c.526= NM_001302689.1:c.526C>T
APOE transcript variant 4 NM_001302690.1:c.526= NM_001302690.1:c.526C>T
apolipoprotein E isoform b precursor NP_000032.1:p.Arg176= NP_000032.1:p.Arg176Cys
apolipoprotein E isoform a precursor NP_001289617.1:p.Arg202= NP_001289617.1:p.Arg202Cys
apolipoprotein E isoform b precursor NP_001289620.1:p.Arg176= NP_001289620.1:p.Arg176Cys
apolipoprotein E isoform b precursor NP_001289618.1:p.Arg176= NP_001289618.1:p.Arg176Cys
apolipoprotein E isoform b precursor NP_001289619.1:p.Arg176= NP_001289619.1:p.Arg176Cys
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

118 SubSNP, 16 Frequency, 8 ClinVar submissions
No Submitter Submission ID Date (Build)
1 CGAP-GAI ss9266 Sep 19, 2000 (52)
2 DEBNICK ss870165 Oct 04, 2000 (86)
3 LEE ss1542565 Oct 04, 2000 (86)
4 LEE ss4429119 May 29, 2002 (106)
5 CUORCGL ss12568612 Aug 26, 2003 (117)
6 SC_SNP ss15840556 Feb 27, 2004 (120)
7 CGAP-GAI ss16231140 Feb 27, 2004 (120)
8 ILLUMINA ss75234864 Dec 07, 2007 (129)
9 RSG_UW ss107936539 Feb 05, 2009 (130)
10 KRIBB_YJKIM ss119338070 Dec 01, 2009 (131)
11 ILLUMINA ss160878071 Dec 01, 2009 (131)
12 COMPLETE_GENOMICS ss168244006 Jul 04, 2010 (132)
13 ILLUMINA ss174365507 Jul 04, 2010 (132)
14 PAGE_STUDY ss181341927 Jul 04, 2010 (132)
15 BUSHMAN ss203765855 Jul 04, 2010 (132)
16 1000GENOMES ss228156555 Jul 14, 2010 (132)
17 1000GENOMES ss237689597 Jul 15, 2010 (132)
18 1000GENOMES ss243892432 Jul 15, 2010 (132)
19 OMICIA ss244239675 May 27, 2010 (132)
20 ILLUMINA ss244309427 Jul 04, 2010 (132)
21 OMIM-CURATED-RECORDS ss275517959 Dec 03, 2010 (133)
22 GMI ss283224141 May 04, 2012 (137)
23 ILLUMINA ss410828265 Sep 17, 2011 (135)
24 PAGE_STUDY ss469414606 May 04, 2012 (137)
25 ILLUMINA ss481561588 May 04, 2012 (137)
26 ILLUMINA ss481591097 May 04, 2012 (137)
27 ILLUMINA ss482563225 Sep 08, 2015 (146)
28 ILLUMINA ss485575806 May 04, 2012 (137)
29 1000GENOMES ss491161753 May 04, 2012 (137)
30 EXOME_CHIP ss491549550 May 04, 2012 (137)
31 NCBI-CURATED-RECORDS ss537712917 Jan 04, 2013 (137)
32 SSMP ss661874597 Apr 25, 2013 (138)
33 NHLBI-ESP ss713519653 Apr 25, 2013 (138)
34 ILLUMINA ss783233469 Sep 08, 2015 (146)
35 ILLUMINA ss783424859 Sep 08, 2015 (146)
36 ILLUMINA ss832493923 Sep 08, 2015 (146)
37 JMKIDD_LAB ss974506673 Aug 21, 2014 (142)
38 EVA-GONL ss994339188 Aug 21, 2014 (142)
39 1000GENOMES ss1363326191 Aug 21, 2014 (142)
40 EVA_GENOME_DK ss1578653636 Apr 01, 2015 (144)
41 EVA_UK10K_ALSPAC ss1638043658 Apr 01, 2015 (144)
42 EVA_UK10K_TWINSUK ss1681037691 Apr 01, 2015 (144)
43 EVA_EXAC ss1693665421 Apr 01, 2015 (144)
44 EVA_DECODE ss1698394132 Apr 01, 2015 (144)
45 EVA_SVP ss1713664899 Apr 01, 2015 (144)
46 ILLUMINA ss1752288225 Sep 08, 2015 (146)
47 ILLUMINA ss1752288226 Sep 08, 2015 (146)
48 ILLUMINA ss1917938922 Feb 12, 2016 (147)
49 WEILL_CORNELL_DGM ss1937835823 Feb 12, 2016 (147)
50 ILLUMINA ss1946537659 Feb 12, 2016 (147)
51 ILLUMINA ss1959869693 Feb 12, 2016 (147)
52 JJLAB ss2029695319 Sep 14, 2016 (149)
53 ILLUMINA ss2094804140 Dec 20, 2016 (150)
54 ILLUMINA ss2095085224 Dec 20, 2016 (150)
55 USC_VALOUEV ss2158238083 Dec 20, 2016 (150)
56 HUMAN_LONGEVITY ss2226012259 Dec 20, 2016 (150)
57 TOPMED ss2391820678 Dec 20, 2016 (150)
58 ILLUMINA ss2633544201 Nov 08, 2017 (151)
59 ILLUMINA ss2633544202 Nov 08, 2017 (151)
60 ILLUMINA ss2635083902 Nov 08, 2017 (151)
61 ILLUMINA ss2710884165 Nov 08, 2017 (151)
62 GNOMAD ss2744090577 Nov 08, 2017 (151)
63 GNOMAD ss2750218836 Nov 08, 2017 (151)
64 GNOMAD ss2963330131 Nov 08, 2017 (151)
65 AFFY ss2985144683 Nov 08, 2017 (151)
66 AFFY ss2985775661 Nov 08, 2017 (151)
67 SWEGEN ss3017540730 Nov 08, 2017 (151)
68 ILLUMINA ss3021911610 Nov 08, 2017 (151)
69 ILLUMINA ss3021911611 Nov 08, 2017 (151)
70 ILLUMINA ss3021911612 Nov 08, 2017 (151)
71 ILLUMINA ss3021911613 Nov 08, 2017 (151)
72 TOPMED ss3294331472 Nov 08, 2017 (151)
73 CSHL ss3352320694 Nov 08, 2017 (151)
74 ILLUMINA ss3625742846 Oct 12, 2018 (152)
75 ILLUMINA ss3625742847 Oct 12, 2018 (152)
76 ILLUMINA ss3625742848 Oct 12, 2018 (152)
77 ILLUMINA ss3625742849 Oct 12, 2018 (152)
78 ILLUMINA ss3633892015 Oct 12, 2018 (152)
79 ILLUMINA ss3634738107 Oct 12, 2018 (152)
80 ILLUMINA ss3634738108 Oct 12, 2018 (152)
81 ILLUMINA ss3635578762 Oct 12, 2018 (152)
82 ILLUMINA ss3636425137 Oct 12, 2018 (152)
83 ILLUMINA ss3637330512 Oct 12, 2018 (152)
84 ILLUMINA ss3638229877 Oct 12, 2018 (152)
85 ILLUMINA ss3640445415 Oct 12, 2018 (152)
86 ILLUMINA ss3640445416 Oct 12, 2018 (152)
87 ILLUMINA ss3641098341 Oct 12, 2018 (152)
88 ILLUMINA ss3643202423 Oct 12, 2018 (152)
89 ILLUMINA ss3644726174 Oct 12, 2018 (152)
90 OMUKHERJEE_ADBS ss3646538370 Oct 12, 2018 (152)
91 ILLUMINA ss3652337714 Oct 12, 2018 (152)
92 ILLUMINA ss3652337715 Oct 12, 2018 (152)
93 ILLUMINA ss3652337716 Oct 12, 2018 (152)
94 ILLUMINA ss3652337717 Oct 12, 2018 (152)
95 ILLUMINA ss3652337718 Oct 12, 2018 (152)
96 ILLUMINA ss3653917429 Oct 12, 2018 (152)
97 EGCUT_WGS ss3684286600 Jul 13, 2019 (153)
98 EVA_DECODE ss3702845772 Jul 13, 2019 (153)
99 ACPOP ss3743072612 Jul 13, 2019 (153)
100 ILLUMINA ss3744466131 Jul 13, 2019 (153)
101 ILLUMINA ss3744466132 Jul 13, 2019 (153)
102 ILLUMINA ss3744466133 Jul 13, 2019 (153)
103 ILLUMINA ss3744466134 Jul 13, 2019 (153)
104 ILLUMINA ss3744466135 Jul 13, 2019 (153)
105 ILLUMINA ss3745038116 Jul 13, 2019 (153)
106 ILLUMINA ss3745038117 Jul 13, 2019 (153)
107 EVA ss3756111787 Jul 13, 2019 (153)
108 ILLUMINA ss3772535200 Jul 13, 2019 (153)
109 ILLUMINA ss3772535201 Jul 13, 2019 (153)
110 PACBIO ss3788541393 Jul 13, 2019 (153)
111 PACBIO ss3793449661 Jul 13, 2019 (153)
112 PACBIO ss3798336543 Jul 13, 2019 (153)
113 KHV_HUMAN_GENOMES ss3821359905 Jul 13, 2019 (153)
114 EVA ss3825301411 Apr 27, 2020 (154)
115 EVA ss3825938286 Apr 27, 2020 (154)
116 EVA ss3835481189 Apr 27, 2020 (154)
117 SGDP_PRJ ss3888305366 Apr 27, 2020 (154)
118 KRGDB ss3938432692 Apr 27, 2020 (154)
119 1000Genomes NC_000019.9 - 45412079 Oct 12, 2018 (152)
120 The Avon Longitudinal Study of Parents and Children NC_000019.9 - 45412079 Oct 12, 2018 (152)
121 Genetic variation in the Estonian population NC_000019.9 - 45412079 Oct 12, 2018 (152)
122 ExAC NC_000019.9 - 45412079 Oct 12, 2018 (152)
123 The Danish reference pan genome NC_000019.9 - 45412079 Apr 27, 2020 (154)
124 gnomAD - Genomes NC_000019.9 - 45412079 Jul 13, 2019 (153)
125 gnomAD - Exomes NC_000019.9 - 45412079 Jul 13, 2019 (153)
126 HapMap NC_000019.10 - 44908822 Apr 27, 2020 (154)
127 KOREAN population from KRGDB NC_000019.9 - 45412079 Apr 27, 2020 (154)
128 Northern Sweden NC_000019.9 - 45412079 Jul 13, 2019 (153)
129 Qatari NC_000019.9 - 45412079 Apr 27, 2020 (154)
130 SGDP_PRJ NC_000019.9 - 45412079 Apr 27, 2020 (154)
131 Siberian NC_000019.9 - 45412079 Apr 27, 2020 (154)
132 TopMed NC_000019.10 - 44908822 Oct 12, 2018 (152)
133 UK 10K study - Twins NC_000019.9 - 45412079 Oct 12, 2018 (152)
134 dbGaP Population Frequency Project NC_000019.10 - 44908822 Apr 27, 2020 (154)
135 ClinVar RCV000019428.30 Oct 12, 2018 (152)
136 ClinVar RCV000019439.29 Apr 27, 2020 (154)
137 ClinVar RCV000019452.30 Oct 12, 2018 (152)
138 ClinVar RCV000019454.30 Oct 12, 2018 (152)
139 ClinVar RCV000211178.1 Oct 12, 2018 (152)
140 ClinVar RCV000346955.2 Apr 27, 2020 (154)
141 ClinVar RCV000825286.1 Apr 27, 2020 (154)
142 ClinVar RCV000845582.1 Apr 27, 2020 (154)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs3200542 Jul 03, 2002 (106)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss168244006, ss203765855, ss283224141, ss481561588, ss1698394132, ss1713664899, ss2635083902, ss3643202423 NC_000019.8:50103918:C:T NC_000019.10:44908821:C:T (self)
76738726, 42493853, 30024848, 4174091, 4835568, 209478715, 13406339, 45610086, 16357477, 19877745, 40322346, 10754437, 42493853, ss228156555, ss237689597, ss243892432, ss481591097, ss482563225, ss485575806, ss491161753, ss491549550, ss661874597, ss713519653, ss783233469, ss783424859, ss832493923, ss974506673, ss994339188, ss1363326191, ss1578653636, ss1638043658, ss1681037691, ss1693665421, ss1752288225, ss1752288226, ss1917938922, ss1937835823, ss1946537659, ss1959869693, ss2029695319, ss2094804140, ss2095085224, ss2158238083, ss2391820678, ss2633544201, ss2633544202, ss2710884165, ss2744090577, ss2750218836, ss2963330131, ss2985144683, ss2985775661, ss3017540730, ss3021911610, ss3021911611, ss3021911612, ss3021911613, ss3352320694, ss3625742846, ss3625742847, ss3625742848, ss3625742849, ss3633892015, ss3634738107, ss3634738108, ss3635578762, ss3636425137, ss3637330512, ss3638229877, ss3640445415, ss3640445416, ss3641098341, ss3644726174, ss3646538370, ss3652337714, ss3652337715, ss3652337716, ss3652337717, ss3652337718, ss3653917429, ss3684286600, ss3743072612, ss3744466131, ss3744466132, ss3744466133, ss3744466134, ss3744466135, ss3745038116, ss3745038117, ss3756111787, ss3772535200, ss3772535201, ss3788541393, ss3793449661, ss3798336543, ss3825301411, ss3825938286, ss3835481189, ss3888305366, ss3938432692 NC_000019.9:45412078:C:T NC_000019.10:44908821:C:T (self)
RCV000019428.30, RCV000019439.29, RCV000019452.30, RCV000019454.30, RCV000211178.1, RCV000346955.2, RCV000825286.1, RCV000845582.1, 1701717, 181977066, 436542286, ss244239675, ss275517959, ss537712917, ss2226012259, ss3294331472, ss3702845772, ss3821359905 NC_000019.10:44908821:C:T NC_000019.10:44908821:C:T (self)
ss15840556 NT_011109.15:17680296:C:T NC_000019.10:44908821:C:T (self)
ss9266, ss870165, ss1542565, ss4429119, ss12568612, ss16231140, ss75234864, ss107936539, ss119338070, ss160878071, ss174365507, ss181341927, ss244309427, ss410828265, ss469414606 NT_011109.16:17680296:C:T NC_000019.10:44908821:C:T (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

360 citations for rs7412
PMID Title Author Year Journal
2992507 Isolation and characterisation of a variant allele of the gene for human apolipoprotein E. Gill LL et al. 1985 Biochemical and biophysical research communications
3243553 Genotyping and sequence analysis of apolipoprotein E isoforms. Emi M et al. 1988 Genomics
6300187 Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia. Rall SC Jr et al. 1983 The Journal of clinical investigation
6323533 A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1. Weisgraber KH et al. 1984 The Journal of clinical investigation
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26175754 DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women. Chagnon YC et al. 2015 Frontiers in genetics
26301579 Association between the Lipid Levels and Single Nucleotide Polymorphisms of ABCA1, APOE and HMGCR Genes in Subjects with Spontaneous Preterm Delivery. Li L et al. 2015 PloS one
26343804 Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults. Sapkota S et al. 2016 International journal of geriatric psychiatry
26362601 Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study. DeCarlo CA et al. 2016 The journals of gerontology. Series B, Psychological sciences and social sciences
26365620 Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men. Son KY et al. 2015 Lipids in health and disease
26404360 Effects of APOE rs429358, rs7412 and GSTM1/GSTT1 Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults. Yuan L et al. 2015 Nutrients
26405973 Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han Population. Zhang X et al. 2015 Bio-medical materials and engineering
26497592 The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis. Pleva L et al. 2015 BMC cardiovascular disorders
26619808 APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease. Vélez JI et al. 2016 Molecular psychiatry
26621708 Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. Schwarz F et al. 2016 Proceedings of the National Academy of Sciences of the United States of America
26627480 Genetic predisposition to acute kidney injury--a systematic review. Vilander LM et al. 2015 BMC nephrology
26661731 ApoA1, ApoJ and ApoE Plasma Levels and Genotype Frequencies in Cerebral Amyloid Angiopathy. Montañola A et al. 2016 Neuromolecular medicine
26669675 Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS. Schrewe L et al. 2015 Journal of neuroinflammation
26677855 Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity. Fortney K et al. 2015 PLoS genetics
26680604 Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China. Jiao B et al. 2015 PloS one
26690118 An Updated Review on the Genetics of Primary Open Angle Glaucoma. Abu-Amero K et al. 2015 International journal of molecular sciences
26726928 Common variants of APOE are associated with anti-epileptic drugs resistance in Han Chinese patients. Gong JE et al. 2017 The International journal of neuroscience
26739746 A multi-factorial analysis of response to warfarin in a UK prospective cohort. Bourgeois S et al. 2016 Genome medicine
26741362 Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico. Gonzalez-Aldaco K et al. 2016 PloS one
26754117 A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism. Zhong L et al. 2016 Molecular neurodegeneration
26756273 Genetics of psychosis of Alzheimer disease. Shah C et al. 2017 American journal of medical genetics. Part B, Neuropsychiatric genetics
26788404 Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population. Lange J et al. 2015 Parkinson's disease
26930295 Genetic landscape of APOE in human longevity revealed by high-throughput sequencing. Ryu S et al. 2016 Mechanisms of ageing and development
26937653 Interleukin-1β Promoter Polymorphism Enhances the Risk of Sleep Disturbance in Alzheimer's Disease. Yin Y et al. 2016 PloS one
26958812 ZCWPW1 is associated with late-onset Alzheimer's disease in Han Chinese: a replication study and meta-analyses. Gao Y et al. 2016 Oncotarget
26971241 Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans. Larifla L et al. 2016 The Canadian journal of cardiology
26977927 A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population. Tong HY et al. 2016 PloS one
26985771 Multiple genetic imaging study of the association between cholesterol metabolism and brain functional alterations in individuals with risk factors for Alzheimer's disease. Bai F et al. 2016 Oncotarget
27003218 Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe. Nho K et al. 2016 Journal of Alzheimer's disease
27015805 Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Pilling LC et al. 2016 Aging
27067897 Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients. Chan DP et al. 2016 BMJ open
27073747 The presenilin 1 p.Gly206Ala mutation is a frequent cause of early-onset Alzheimer's disease in Hispanics in Florida. Ravenscroft TA et al. 2016 American journal of neurodegenerative disease
27112212 Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II. Shahid SU et al. 2016 Lipids in health and disease
27177774 Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population. Wu S et al. 2016 Lipids in health and disease
27189021 Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility. Cook JP et al. 2016 European journal of human genetics
27193889 The algorithm for Alzheimer risk assessment based on APOE promoter polymorphisms. Limon-Sztencel A et al. 2016 Alzheimer's research & therapy
27227539 The Contribution of GWAS Loci in Familial Dyslipidemias. Ripatti P et al. 2016 PLoS genetics
27239546 Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Gupta VB et al. 2016 Alzheimer's & dementia (Amsterdam, Netherlands)
27239555 Oxidative stress, innate immunity, and age-related macular degeneration. Shaw PX et al. 2016 AIMS molecular science
27240396 Analysis of the Relationship between Estradiol and Follicle-Stimulating Hormone Concentrations and Polymorphisms of Apolipoprotein E and LeptinGenes in Women Post-Menopause. Rył A et al. 2016 International journal of environmental research and public health
27244899 FERMT2 rs17125944 polymorphism with Alzheimer's disease risk: a replication and meta-analysis. Zhang QY et al. 2016 Oncotarget
27249957 CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking. Weng PH et al. 2016 Scientific reports
27276684 MEF2C rs190982 polymorphism with late-onset Alzheimer's disease in Han Chinese: A replication study and meta-analyses. Tang SS et al. 2016 Oncotarget
27289440 ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Sassi C et al. 2016 Neurobiology of aging
27301361 Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases. Tšuiko O et al. 2016 Human reproduction (Oxford, England)
27358062 A loss of function variant in CASP7 protects against Alzheimer's disease in homozygous APOE ε4 allele carriers. Ayers KL et al. 2016 BMC genomics
27439317 Cholesteryl ester transfer protein (CETP) I405V polymorphism and cardiovascular disease in eastern European Caucasians - a cross-sectional study. Bustami J et al. 2016 BMC geriatrics
27453991 A novel approach for multi-SNP GWAS and its application in Alzheimer's disease. Bodily PM et al. 2016 BMC bioinformatics
27482534 An Alzheimer's Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults. Harrison TM et al. 2016 eNeuro
27494614 Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations. Dinov ID et al. 2016 PloS one
27540764 Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age. Noordam R et al. 2016 Aging
27583919 The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population. Zheng J et al. 2016 Medicine
27584680 Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. Ding N et al. 2016 PloS one
27589735 A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification. Ponasenko AV et al. 2016 International journal of molecular sciences
27662287 Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease. Darst BF et al. 2017 Journal of Alzheimer's disease
27677442 Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes. Weber KS et al. 2016 Cardiovascular diabetology
27716211 A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics. Beaney KE et al. 2016 Cardiovascular diabetology
27724906 Association of apolipoprotein E polymorphism with plasma lipid disorders, independent of obesity-related traits in Vietnamese children. Hanh NT et al. 2016 Lipids in health and disease
27775101 Incorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response. Graham HT et al. 2016 Frontiers in genetics
27783031 Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B<sub>12</sub> and Hcy Status with Cognitive Functions in Chinese Adults. Cai C et al. 2016 Nutrients
27798356 Lack of replication of associations between multiple genetic polymorphisms and endurance athlete status in Japanese population. Yvert T et al. 2016 Physiological reports
27805002 Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer's Disease. Chen YC et al. 2016 Scientific reports
27814994 The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder. Gan-Or Z et al. 2017 Neurobiology of aging
27943270 A genetic risk score is significantly associated with statin therapy response in the elderly population. Ciuculete DM et al. 2017 Clinical genetics
27979356 Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. Irwin DJ et al. 2017 The Lancet. Neurology
28034305 SORL1 gene, plasma biomarkers, and the risk of Alzheimer's disease for the Han Chinese population in Taiwan. Chou CT et al. 2016 Alzheimer's research & therapy
28050343 Brain insulin resistance deteriorates cognition by altering the topological features of brain networks. Su F et al. 2017 NeuroImage. Clinical
28079798 Clinical and genetic factors associated with warfarin maintenance dose in northern Chinese patients with mechanical heart valve replacement. Liu R et al. 2017 Medicine
28086795 Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study. Fawzy MS et al. 2017 BMC cardiovascular disorders
28099408 Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202. Verma A et al. 2017 Pharmacogenetics and genomics
28123423 Apolipoprotein E polymorphisms increase the risk of post-stroke depression. Li XB et al. 2016 Neural regeneration research
28167353 Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. Shahid SU et al. 2017 Atherosclerosis
28189700 CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. Fardo DW et al. 2017 Experimental gerontology
28253266 Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis. Wu X et al. 2017 PloS one
28371326 Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study. Zhu Y et al. 2017 Journal of cellular and molecular medicine
28388928 SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature. Bokharaeian B et al. 2017 Journal of biomedical semantics
28399184 Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease. Huertas I et al. 2017 PloS one
28449691 The impact of rare and low-frequency genetic variants in common disease. Bomba L et al. 2017 Genome biology
28464262 A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans. Reales G et al. 2017 American journal of physical anthropology
28480219 Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort. Norda S et al. 2017 BioMed research international
28512139 A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms. Mack S et al. 2017 Journal of lipid research
28558900 Effect of CLU and PICALM polymorphisms on AD risk: A study from south India. Shankarappa BM et al. 2017 Asian journal of psychiatry
28577571 Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review. Paththinige CS et al. 2017 Lipids in health and disease
28605058 Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia. Ward KM et al. 2017 Pharmacotherapy
28645497 An association between polymorphisms within the APOE gene and concussion aetiology in rugby union players. Abrahams S et al. 2018 Journal of science and medicine in sport
28672022 APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. Yu L et al. 2017 PloS one
28686695 Coronary artery disease-associated genetic variants and biomarkers of inflammation. Christiansen MK et al. 2017 PloS one
28705542 Effect of Coronary Artery Disease risk SNPs on serum cytokine levels and cytokine imbalance in Premature Coronary Artery Disease. Ansari WM et al. 2019 Cytokine
28720344 APOE genotype associates with food consumption and body composition to predict dyslipidaemia in Brazilian adults with normal-weight obesity syndrome. Franco LP et al. 2018 Clinical nutrition (Edinburgh, Scotland)
28727855 Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans. Larifla L et al. 2017 PloS one
28800603 Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort. Arpawong TE et al. 2017 PloS one
28812116 SLCO1B1 521T &gt; C polymorphism associated with rosuvastatin-induced myotoxicity in Chinese coronary artery disease patients: a nested case-control study. Liu JE et al. 2017 European journal of clinical pharmacology
28824412 ApoE rs429358 and rs7412 Polymorphism and Gender Differences of Serum Lipid Profile and Cognition in Aging Chinese Population. Zhen J et al. 2017 Frontiers in aging neuroscience
28840058 P2X<sub>7</sub> Receptor and APOE Polymorphisms and Survival from Heart Failure: A Prospective Study in Frail Patients in a Geriatric Unit. Pasqualetti G et al. 2017 Aging and disease
29059476 Influence of Apolipoprotein E polymorphism on susceptibility of Wilson disease. Roy S et al. 2018 Annals of human genetics
29074556 Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population. Zhao LL et al. 2017 Bioscience reports
29125573 Tailoring Nutritional Advice for Mexicans Based on Prevalence Profiles of Diet-Related Adaptive Gene Polymorphisms. Ojeda-Granados C et al. 2017 Journal of personalized medicine
29193749 Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years. Borobia AM et al. 2018 Clinical and translational science
29201112 Association of Warfarin Therapy with <i>APOE</i> and <i>VKORC1</i> Genes Polymorphism in Iranian Population. Rafiee S et al. 2017 Iranian journal of pharmaceutical research
29213291 Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population. Suvatha A et al. 2017 Cellular & molecular biology letters
29340220 Multilocus Analysis of Genetic Susceptibility to Myocardial Infarction in Russians: Replication Study. Kukava NG et al. 2017 Acta naturae
29395286 An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk. Rao S et al. 2018 Neurobiology of aging
29532745 Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis. Graetz C et al. 2019 Multiple sclerosis (Houndmills, Basingstoke, England)
29534716 Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals. Nordestgaard LT et al. 2018 BMC medicine
29558945 Evaluation of candidate genes associated with hepatitis A and E virus infection in Chinese Han population. Gu M et al. 2018 Virology journal
29712557 Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors. Shatwan IM et al. 2018 Lipids in health and disease
29764032 [Genes polymorphism of BIN1 and ApoE in patients with amnestic mild cognitive impairment from Enshi Tujia area]. Chen J et al. 2018 Zhonghua yi xue za zhi
29776682 The impact of Apolipoprotein E alleles on cognitive performance in patients with Parkinson's disease. Pierzchlińska A et al. 2018 Neurologia i neurochirurgia polska
29851526 The role of apolipoprotein E (rs7412 and rs429358) in age-related macular degeneration. Liutkeviciene R et al. 2018 Ophthalmic genetics
29892926 The relationship between genetic polymorphisms in apolipoprotein E (ApoE) gene and osteonecrosis of the femoral head induced by steroid in Chinese Han population. Yuan L et al. 2018 Genes & genomics
29932521 Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia. Pawlikowska L et al. 2018 Molecular genetics & genomic medicine
29942042 A decade in psychiatric GWAS research. Horwitz T et al. 2019 Molecular psychiatry
29972410 Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants. Pereira A et al. 2018 Arquivos brasileiros de cardiologia
29976289 Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides, and Incident Cardiovascular Disease. Saeed A et al. 2018 Journal of the American College of Cardiology
29996665 The Effect of the Relationship of APOE Polymorphisms and Cerebral Vasospasm on Functional Outcomes in Children With Traumatic Brain Injury. Reuter-Rice K et al. 2018 Biological research for nursing
30088610 An association study of FOXO3 variant and longevity. Silva-Sena GG et al. 2018 Genetics and molecular biology
30112393 Combination of Genetic Markers and Age Effectively Facilitates the Identification of People with High Risk of Preeclampsia in the Han Chinese Population. Zhou L et al. 2018 BioMed research international
30202567 Genetic findings in sport-related concussions: potential for individualized medicine? McDevitt J et al. 2017 Concussion (London, England)
30235358 Role of Apolipoprotein E gene polymorphism in the risk of familial hypercholesterolemia: a case-control study. Almigbal TH et al. 2018 Acta biochimica Polonica
30338758 First Bosnian Study of the Relationship between APOE rs7412 and rs429358 Variants and Pregnancy Loss. Adler G et al. 2018 Folia biologica
30462377 Independent associations of TOMM40 and APOE variants with body mass index. Kulminski AM et al. 2019 Aging cell
30478798 Childhood trauma interacts with ApoE to influence neurocognitive function in women living with HIV. Womersley JS et al. 2019 Journal of neurovirology
30571812 Additional value of a combined genetic risk score to standard cardiovascular stratification. Pereira A et al. 2018 Genetics and molecular biology
30576806 APOE hypermethylation is significantly associated with coronary heart disease in males. Ji H et al. 2019 Gene
30584432 Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study. Daneshpour MS et al. 2018 International journal of endocrinology and metabolism
30660866 Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line. Schmid B et al. 2019 Stem cell research
30679475 The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study. Karjalainen JP et al. 2019 Scientific reports
30740535 Coronary artery disease, genetic risk and the metabolome in young individuals. Battram T et al. 2018 Wellcome open research
30788380 Association study between DNA methylation and genetic variation of <i>APOE</i> gene with the risk of coronary artery disease. Ghaznavi H et al. 2018 Molecular biology research communications
30819100 10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors. Tindale LC et al. 2019 BMC geriatrics
30909076 BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy. Doherty C et al. 2019 Epilepsy & behavior
31054363 Association of ApoE haplotype with clinical evidence of pituitary adenoma. Sidaraite A et al. 2019 Gene
31126849 Role of APOE and IL18RAP gene polymorphisms in cervical spondylotic myelopathy in Indian population. Diptiranjan S et al. 2019 Journal of clinical neuroscience
31127079 Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment. Chaudhury S et al. 2019 Translational psychiatry
31134487 Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson's Disease: A Study from Eastern India. Pal P et al. 2019 Neuromolecular medicine
31166609 Apolipoprotein E genetic variants interact with Mediterranean diet to modulate postprandial hypertriglyceridemia in coronary heart disease patients: CORDIOPREV study. Gomez-Delgado F et al. 2019 European journal of clinical investigation
31192002 Multiple Gene Polymorphisms Associated with Exfoliation Syndrome in the Uygur Population. Ma YN et al. 2019 Journal of ophthalmology
31249592 The Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2<sup>nd</sup> Trimester Lipid Levels and Preterm Birth. Kovac U et al. 2019 Frontiers in genetics
31381519 APOE ɛ4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke. Werden E et al. 2019 Journal of Alzheimer's disease
31413261 A meta-analysis of genome-wide association studies identifies multiple longevity genes. Deelen J et al. 2019 Nature communications
31469155 The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer's disease. Santos LRD et al. 2020 Genetics and molecular biology
31480637 Impact of the <i>Apolipoprotein E</i> (epsilon) Genotype on Cardiometabolic Risk Markers and Responsiveness to Acute and Chronic Dietary Fat Manipulation. Rathnayake KM et al. 2019 Nutrients
31481563 Cohort profile: role of lipoproteins in cardiovascular disease-the LipidCardio study. König M et al. 2019 BMJ open
31523375 Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults. Camargos EF et al. 2019 International journal of molecular epidemiology and genetics
31559922 APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population. Wang C et al. 2019 Pharmacogenomics
31585025 The influence of gene polymorphisms on postprandial triglyceride response after oral fat tolerance test meal in patients with diabetes mellitus. Gavra P et al. 2019 International journal of clinical practice
31654486 The association study of lipid metabolism gene polymorphisms with AMD identifies a protective role for APOE-E2 allele in the wet form in a Northern Spanish population. Fernández-Vega B et al. 2020 Acta ophthalmologica
31854268 Impact of <i>CYP2C9</i>, <i>VKORC1</i>, <i>ApoE</i> and <i>ABCB1</i> polymorphisms on stable warfarin dose requirements in elderly Chinese patients. Li W et al. 2020 Pharmacogenomics
31861518 Genetic Associations with Aging Muscle: A Systematic Review. Pratt J et al. 2019 Cells
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The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
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