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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs737866

Current Build 155

Released April 9, 2021

Organism
Homo sapiens
Position
chr22:19942586 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
T>A / T>C
Variation Type
SNV Single Nucleotide Variation
Frequency
C=0.279062 (82277/294834, ALFA)
C=0.227655 (60258/264690, TOPMED)
C=0.18608 (14644/78696, PAGE_STUDY) (+ 18 more)
C=0.24714 (4142/16760, 8.3KJPN)
C=0.2266 (1135/5008, 1000G)
C=0.2353 (1054/4480, Estonian)
C=0.2833 (1092/3854, ALSPAC)
C=0.2905 (1077/3708, TWINSUK)
C=0.2898 (849/2930, KOREAN)
C=0.2404 (501/2084, HGDP_Stanford)
C=0.2299 (435/1892, HapMap)
C=0.2893 (530/1832, Korea1K)
C=0.278 (277/998, GoNL)
C=0.303 (227/750, PRJEB37584)
C=0.240 (144/600, NorthernSweden)
C=0.246 (59/240, PharmGKB)
C=0.264 (57/216, Qatari)
T=0.406 (86/212, SGDP_PRJ)
C=0.27 (26/96, Ancient Sardinia)
C=0.17 (7/40, GENOME_DK)
T=0.31 (8/26, Siberian)
Clinical Significance
Not Reported in ClinVar
Gene : Consequence
COMT : Intron Variant
TXNRD2 : 2KB Upstream Variant
Publications
15 citations
Genomic View
See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 294834 T=0.720938 A=0.000000, C=0.279062
European Sub 261754 T=0.712211 A=0.000000, C=0.287789
African Sub 7206 T=0.8940 A=0.0000, C=0.1060
African Others Sub 290 T=0.931 A=0.000, C=0.069
African American Sub 6916 T=0.8924 A=0.0000, C=0.1076
Asian Sub 3882 T=0.7290 A=0.0000, C=0.2710
East Asian Sub 3150 T=0.7219 A=0.0000, C=0.2781
Other Asian Sub 732 T=0.760 A=0.000, C=0.240
Latin American 1 Sub 1064 T=0.7632 A=0.0000, C=0.2368
Latin American 2 Sub 7060 T=0.8373 A=0.0000, C=0.1627
South Asian Sub 5186 T=0.7295 A=0.0000, C=0.2705
Other Sub 8682 T=0.7320 A=0.0000, C=0.2680


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
Allele Frequency Aggregator Total Global 294834 T=0.720938 A=0.000000, C=0.279062
Allele Frequency Aggregator European Sub 261754 T=0.712211 A=0.000000, C=0.287789
Allele Frequency Aggregator Other Sub 8682 T=0.7320 A=0.0000, C=0.2680
Allele Frequency Aggregator African Sub 7206 T=0.8940 A=0.0000, C=0.1060
Allele Frequency Aggregator Latin American 2 Sub 7060 T=0.8373 A=0.0000, C=0.1627
Allele Frequency Aggregator South Asian Sub 5186 T=0.7295 A=0.0000, C=0.2705
Allele Frequency Aggregator Asian Sub 3882 T=0.7290 A=0.0000, C=0.2710
Allele Frequency Aggregator Latin American 1 Sub 1064 T=0.7632 A=0.0000, C=0.2368
TopMed Global Study-wide 264690 T=0.772345 C=0.227655
The PAGE Study Global Study-wide 78696 T=0.81392 C=0.18608
The PAGE Study AfricanAmerican Sub 32514 T=0.84933 C=0.15067
The PAGE Study Mexican Sub 10810 T=0.82266 C=0.17734
The PAGE Study Asian Sub 8316 T=0.7502 C=0.2498
The PAGE Study PuertoRican Sub 7918 T=0.8023 C=0.1977
The PAGE Study NativeHawaiian Sub 4532 T=0.7851 C=0.2149
The PAGE Study Cuban Sub 4230 T=0.7288 C=0.2712
The PAGE Study Dominican Sub 3828 T=0.7811 C=0.2189
The PAGE Study CentralAmerican Sub 2450 T=0.8465 C=0.1535
The PAGE Study SouthAmerican Sub 1982 T=0.8244 C=0.1756
The PAGE Study NativeAmerican Sub 1260 T=0.7722 C=0.2278
The PAGE Study SouthAsian Sub 856 T=0.748 C=0.252
8.3KJPN JAPANESE Study-wide 16760 T=0.75286 C=0.24714
1000Genomes Global Study-wide 5008 T=0.7734 C=0.2266
1000Genomes African Sub 1322 T=0.8737 C=0.1263
1000Genomes East Asian Sub 1008 T=0.7063 C=0.2937
1000Genomes Europe Sub 1006 T=0.7187 C=0.2813
1000Genomes South Asian Sub 978 T=0.733 C=0.267
1000Genomes American Sub 694 T=0.816 C=0.184
Genetic variation in the Estonian population Estonian Study-wide 4480 T=0.7647 C=0.2353
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 T=0.7167 C=0.2833
UK 10K study - Twins TWIN COHORT Study-wide 3708 T=0.7095 C=0.2905
KOREAN population from KRGDB KOREAN Study-wide 2930 T=0.7102 A=0.0000, C=0.2898
HGDP-CEPH-db Supplement 1 Global Study-wide 2084 T=0.7596 C=0.2404
HGDP-CEPH-db Supplement 1 Est_Asia Sub 470 T=0.728 C=0.272
HGDP-CEPH-db Supplement 1 Central_South_Asia Sub 414 T=0.732 C=0.268
HGDP-CEPH-db Supplement 1 Middle_Est Sub 350 T=0.689 C=0.311
HGDP-CEPH-db Supplement 1 Europe Sub 320 T=0.703 C=0.297
HGDP-CEPH-db Supplement 1 Africa Sub 242 T=0.851 C=0.149
HGDP-CEPH-db Supplement 1 America Sub 216 T=0.991 C=0.009
HGDP-CEPH-db Supplement 1 Oceania Sub 72 T=0.72 C=0.28
HapMap Global Study-wide 1892 T=0.7701 C=0.2299
HapMap American Sub 770 T=0.747 C=0.253
HapMap African Sub 692 T=0.842 C=0.158
HapMap Asian Sub 254 T=0.685 C=0.315
HapMap Europe Sub 176 T=0.710 C=0.290
Korean Genome Project KOREAN Study-wide 1832 T=0.7107 C=0.2893
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 T=0.722 C=0.278
CNV burdens in cranial meningiomas Global Study-wide 750 T=0.697 C=0.303
CNV burdens in cranial meningiomas CRM Sub 750 T=0.697 C=0.303
Northern Sweden ACPOP Study-wide 600 T=0.760 C=0.240
PharmGKB Aggregated Global Study-wide 240 T=0.754 C=0.246
PharmGKB Aggregated PA151927220 Sub 240 T=0.754 C=0.246
Qatari Global Study-wide 216 T=0.736 C=0.264
SGDP_PRJ Global Study-wide 212 T=0.406 C=0.594
Ancient Sardinia genome-wide 1240k capture data generation and analysis Global Study-wide 96 T=0.73 C=0.27
The Danish reference pan genome Danish Study-wide 40 T=0.82 C=0.17
Siberian Global Study-wide 26 T=0.31 C=0.69
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 22 NC_000022.11:g.19942586T>A
GRCh38.p13 chr 22 NC_000022.11:g.19942586T>C
GRCh37.p13 chr 22 NC_000022.10:g.19930109T>A
GRCh37.p13 chr 22 NC_000022.10:g.19930109T>C
TXNRD2 RefSeqGene (LRG_417) NG_011835.1:g.4251A>T
TXNRD2 RefSeqGene (LRG_417) NG_011835.1:g.4251A>G
COMT RefSeqGene (LRG_1010) NG_011526.1:g.5847T>A
COMT RefSeqGene (LRG_1010) NG_011526.1:g.5847T>C
Gene: COMT, catechol-O-methyltransferase (plus strand)
Molecule type Change Amino acid[Codon] SO Term
COMT transcript variant 1 NM_000754.4:c.-92+689T>A N/A Intron Variant
COMT transcript variant 5 NM_001362828.2:c.-386+689…

NM_001362828.2:c.-386+689T>A

N/A Intron Variant
COMT transcript variant 2 NM_001135161.2:c. N/A Genic Upstream Transcript Variant
COMT transcript variant 3 NM_001135162.2:c. N/A Genic Upstream Transcript Variant
COMT transcript variant 4 NM_007310.3:c. N/A Genic Upstream Transcript Variant
Gene: TXNRD2, thioredoxin reductase 2 (minus strand) : 2KB Upstream Variant
Molecule type Change Amino acid[Codon] SO Term
TXNRD2 transcript variant 5 NM_001282512.3:c. N/A Upstream Transcript Variant
TXNRD2 transcript variant 2 NM_001352300.2:c. N/A Upstream Transcript Variant
TXNRD2 transcript variant 1 NM_006440.5:c. N/A Upstream Transcript Variant
TXNRD2 transcript variant 3 NM_001352301.2:c. N/A N/A
TXNRD2 transcript variant 4 NM_001352302.2:c. N/A N/A
TXNRD2 transcript variant 6 NM_001352303.2:c. N/A N/A
TXNRD2 transcript variant 7 NR_147957.2:n. N/A Upstream Transcript Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement T= A C
GRCh38.p13 chr 22 NC_000022.11:g.19942586= NC_000022.11:g.19942586T>A NC_000022.11:g.19942586T>C
GRCh37.p13 chr 22 NC_000022.10:g.19930109= NC_000022.10:g.19930109T>A NC_000022.10:g.19930109T>C
TXNRD2 RefSeqGene (LRG_417) NG_011835.1:g.4251= NG_011835.1:g.4251A>T NG_011835.1:g.4251A>G
COMT RefSeqGene (LRG_1010) NG_011526.1:g.5847= NG_011526.1:g.5847T>A NG_011526.1:g.5847T>C
COMT transcript variant 1 NM_000754.3:c.-92+689= NM_000754.3:c.-92+689T>A NM_000754.3:c.-92+689T>C
COMT transcript variant 1 NM_000754.4:c.-92+689= NM_000754.4:c.-92+689T>A NM_000754.4:c.-92+689T>C
COMT transcript variant 5 NM_001362828.2:c.-386+689= NM_001362828.2:c.-386+689T>A NM_001362828.2:c.-386+689T>C
COMT transcript variant X1 XM_005261229.1:c.-386+689= XM_005261229.1:c.-386+689T>A XM_005261229.1:c.-386+689T>C
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

114 SubSNP, 23 Frequency submissions
No Submitter Submission ID Date (Build)
1 TSC-CSHL ss84952 Oct 05, 2000 (86)
2 SC_JCM ss5809154 Feb 20, 2003 (111)
3 EGP_SNPS ss12673693 Dec 05, 2003 (119)
4 PERLEGEN ss24556280 Sep 20, 2004 (123)
5 ABI ss44321933 Mar 14, 2006 (126)
6 KRIBB_YJKIM ss65825923 Dec 03, 2006 (127)
7 ILLUMINA ss66723507 Dec 03, 2006 (127)
8 ILLUMINA ss67574446 Dec 03, 2006 (127)
9 ILLUMINA ss67955598 Dec 03, 2006 (127)
10 PERLEGEN ss69277078 May 16, 2007 (127)
11 ILLUMINA ss70925845 May 25, 2008 (130)
12 ILLUMINA ss71526746 May 16, 2007 (127)
13 ILLUMINA ss75654303 Dec 07, 2007 (129)
14 ILLUMINA ss79255748 Dec 15, 2007 (130)
15 KRIBB_YJKIM ss83541994 Dec 15, 2007 (130)
16 PHARMGKB_PPII ss84140170 Dec 15, 2007 (130)
17 BCMHGSC_JDW ss91877462 Mar 24, 2008 (129)
18 SNP500CANCER ss105439098 Feb 06, 2009 (130)
19 1000GENOMES ss112551319 Jan 25, 2009 (130)
20 ILLUMINA ss122749178 Dec 01, 2009 (131)
21 ENSEMBL ss138335162 Dec 01, 2009 (131)
22 ILLUMINA ss154422667 Dec 01, 2009 (131)
23 GMI ss157034291 Dec 01, 2009 (131)
24 ILLUMINA ss159597772 Dec 01, 2009 (131)
25 ILLUMINA ss160876808 Dec 01, 2009 (131)
26 COMPLETE_GENOMICS ss167682523 Jul 04, 2010 (132)
27 ILLUMINA ss172286785 Jul 04, 2010 (132)
28 ILLUMINA ss174359358 Jul 04, 2010 (132)
29 1000GENOMES ss228618053 Jul 14, 2010 (132)
30 1000GENOMES ss238022238 Jul 15, 2010 (132)
31 1000GENOMES ss244151608 Jul 15, 2010 (132)
32 BL ss255842420 May 09, 2011 (134)
33 GMI ss283587126 May 04, 2012 (137)
34 GMI ss287550200 Apr 25, 2013 (138)
35 ILLUMINA ss481557729 May 04, 2012 (137)
36 ILLUMINA ss481587145 May 04, 2012 (137)
37 ILLUMINA ss482559431 Sep 08, 2015 (146)
38 ILLUMINA ss485573877 May 04, 2012 (137)
39 ILLUMINA ss537468700 Sep 08, 2015 (146)
40 TISHKOFF ss566560653 Apr 25, 2013 (138)
41 SSMP ss662483623 Apr 25, 2013 (138)
42 ILLUMINA ss778973728 Sep 08, 2015 (146)
43 ILLUMINA ss783232496 Sep 08, 2015 (146)
44 ILLUMINA ss784186615 Sep 08, 2015 (146)
45 ILLUMINA ss825586266 Apr 01, 2015 (144)
46 ILLUMINA ss832492936 Sep 08, 2015 (146)
47 ILLUMINA ss833108785 Jul 13, 2019 (153)
48 ILLUMINA ss834435809 Sep 08, 2015 (146)
49 EVA-GONL ss995222584 Aug 21, 2014 (142)
50 JMKIDD_LAB ss1082570339 Aug 21, 2014 (142)
51 1000GENOMES ss1366682427 Aug 21, 2014 (142)
52 DDI ss1429219715 Apr 01, 2015 (144)
53 EVA_GENOME_DK ss1579704196 Apr 01, 2015 (144)
54 EVA_UK10K_ALSPAC ss1639753621 Apr 01, 2015 (144)
55 EVA_UK10K_TWINSUK ss1682747654 Apr 01, 2015 (144)
56 EVA_DECODE ss1699291708 Apr 01, 2015 (144)
57 EVA_SVP ss1713731227 Apr 01, 2015 (144)
58 ILLUMINA ss1752413942 Sep 08, 2015 (146)
59 HAMMER_LAB ss1809733891 Sep 08, 2015 (146)
60 WEILL_CORNELL_DGM ss1938784172 Feb 12, 2016 (147)
61 ILLUMINA ss1946577570 Feb 12, 2016 (147)
62 ILLUMINA ss1959965669 Feb 12, 2016 (147)
63 JJLAB ss2030165110 Sep 14, 2016 (149)
64 USC_VALOUEV ss2158775024 Dec 20, 2016 (150)
65 HUMAN_LONGEVITY ss2246455616 Dec 20, 2016 (150)
66 TOPMED ss2413282472 Dec 20, 2016 (150)
67 SYSTEMSBIOZJU ss2629580683 Nov 08, 2017 (151)
68 ILLUMINA ss2633862723 Nov 08, 2017 (151)
69 GRF ss2704517964 Nov 08, 2017 (151)
70 ILLUMINA ss2710952854 Nov 08, 2017 (151)
71 GNOMAD ss2972984362 Nov 08, 2017 (151)
72 SWEGEN ss3019086014 Nov 08, 2017 (151)
73 ILLUMINA ss3022171854 Nov 08, 2017 (151)
74 BIOINF_KMB_FNS_UNIBA ss3028920254 Nov 08, 2017 (151)
75 CSHL ss3352776384 Nov 08, 2017 (151)
76 TOPMED ss3374056850 Nov 08, 2017 (151)
77 TOPMED ss3374056851 Nov 08, 2017 (151)
78 ILLUMINA ss3625799471 Oct 12, 2018 (152)
79 ILLUMINA ss3628505954 Oct 12, 2018 (152)
80 ILLUMINA ss3631815129 Oct 12, 2018 (152)
81 ILLUMINA ss3633268838 Oct 12, 2018 (152)
82 ILLUMINA ss3633984226 Oct 12, 2018 (152)
83 ILLUMINA ss3634860914 Oct 12, 2018 (152)
84 ILLUMINA ss3635668865 Oct 12, 2018 (152)
85 ILLUMINA ss3636556549 Oct 12, 2018 (152)
86 ILLUMINA ss3637421056 Oct 12, 2018 (152)
87 ILLUMINA ss3638374411 Oct 12, 2018 (152)
88 ILLUMINA ss3639191040 Oct 12, 2018 (152)
89 ILLUMINA ss3639611676 Oct 12, 2018 (152)
90 ILLUMINA ss3640568215 Oct 12, 2018 (152)
91 ILLUMINA ss3643334822 Oct 12, 2018 (152)
92 ILLUMINA ss3644796311 Oct 12, 2018 (152)
93 ILLUMINA ss3652633407 Oct 12, 2018 (152)
94 EGCUT_WGS ss3685618566 Jul 13, 2019 (153)
95 EVA_DECODE ss3707954568 Jul 13, 2019 (153)
96 ILLUMINA ss3725957465 Jul 13, 2019 (153)
97 ACPOP ss3743823083 Jul 13, 2019 (153)
98 ILLUMINA ss3744205012 Jul 13, 2019 (153)
99 ILLUMINA ss3745160746 Jul 13, 2019 (153)
100 EVA ss3759230684 Jul 13, 2019 (153)
101 PAGE_CC ss3772082248 Jul 13, 2019 (153)
102 ILLUMINA ss3772656730 Jul 13, 2019 (153)
103 KHV_HUMAN_GENOMES ss3822398587 Jul 13, 2019 (153)
104 EVA ss3835927685 Apr 27, 2020 (154)
105 EVA ss3841592346 Apr 27, 2020 (154)
106 EVA ss3847107003 Apr 27, 2020 (154)
107 HGDP ss3847684681 Apr 27, 2020 (154)
108 SGDP_PRJ ss3890256408 Apr 27, 2020 (154)
109 KRGDB ss3940639888 Apr 27, 2020 (154)
110 KOGIC ss3983389233 Apr 27, 2020 (154)
111 EVA ss3984758310 Apr 26, 2021 (155)
112 EVA ss3985910166 Apr 26, 2021 (155)
113 TOPMED ss5105102546 Apr 26, 2021 (155)
114 TOMMO_GENOMICS ss5232039685 Apr 26, 2021 (155)
115 1000Genomes NC_000022.10 - 19930109 Oct 12, 2018 (152)
116 The Avon Longitudinal Study of Parents and Children NC_000022.10 - 19930109 Oct 12, 2018 (152)
117 Genetic variation in the Estonian population NC_000022.10 - 19930109 Oct 12, 2018 (152)
118 The Danish reference pan genome NC_000022.10 - 19930109 Apr 27, 2020 (154)
119 gnomAD - Genomes

Submission ignored due to conflicting rows:
Row 566538959 (NC_000022.11:19942585:T:A 2/140132)
Row 566538960 (NC_000022.11:19942585:T:C 32077/140084)

- Apr 26, 2021 (155)
120 gnomAD - Genomes

Submission ignored due to conflicting rows:
Row 566538959 (NC_000022.11:19942585:T:A 2/140132)
Row 566538960 (NC_000022.11:19942585:T:C 32077/140084)

- Apr 26, 2021 (155)
121 Genome of the Netherlands Release 5 NC_000022.10 - 19930109 Apr 27, 2020 (154)
122 HGDP-CEPH-db Supplement 1 NC_000022.9 - 18310109 Apr 27, 2020 (154)
123 HapMap NC_000022.11 - 19942586 Apr 27, 2020 (154)
124 KOREAN population from KRGDB NC_000022.10 - 19930109 Apr 27, 2020 (154)
125 Korean Genome Project NC_000022.11 - 19942586 Apr 27, 2020 (154)
126 Northern Sweden NC_000022.10 - 19930109 Jul 13, 2019 (153)
127 The PAGE Study NC_000022.11 - 19942586 Jul 13, 2019 (153)
128 Ancient Sardinia genome-wide 1240k capture data generation and analysis NC_000022.10 - 19930109 Apr 26, 2021 (155)
129 CNV burdens in cranial meningiomas NC_000022.10 - 19930109 Apr 26, 2021 (155)
130 PharmGKB Aggregated NC_000022.11 - 19942586 Apr 27, 2020 (154)
131 Qatari NC_000022.10 - 19930109 Apr 27, 2020 (154)
132 SGDP_PRJ NC_000022.10 - 19930109 Apr 27, 2020 (154)
133 Siberian NC_000022.10 - 19930109 Apr 27, 2020 (154)
134 8.3KJPN NC_000022.10 - 19930109 Apr 26, 2021 (155)
135 TopMed NC_000022.11 - 19942586 Apr 26, 2021 (155)
136 UK 10K study - Twins NC_000022.10 - 19930109 Oct 12, 2018 (152)
137 ALFA NC_000022.11 - 19942586 Apr 26, 2021 (155)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs17455584 Oct 07, 2004 (123)
rs60054527 May 25, 2008 (130)
rs386609683 Aug 21, 2014 (142)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
47817282, ss3940639888 NC_000022.10:19930108:T:A NC_000022.11:19942585:T:A (self)
7902659793, ss3374056850 NC_000022.11:19942585:T:A NC_000022.11:19942585:T:A (self)
ss3639191040, ss3639611676 NC_000022.8:18304662:T:C NC_000022.11:19942585:T:C (self)
362573, ss91877462, ss112551319, ss167682523, ss255842420, ss283587126, ss287550200, ss481557729, ss825586266, ss1699291708, ss1713731227, ss3643334822, ss3847684681 NC_000022.9:18310108:T:C NC_000022.11:19942585:T:C (self)
80216837, 44381651, 31356814, 5869135, 19773706, 47817282, 17107948, 1136093, 307891, 20826094, 42273388, 11291378, 90008992, 44381651, ss228618053, ss238022238, ss244151608, ss481587145, ss482559431, ss485573877, ss537468700, ss566560653, ss662483623, ss778973728, ss783232496, ss784186615, ss832492936, ss833108785, ss834435809, ss995222584, ss1082570339, ss1366682427, ss1429219715, ss1579704196, ss1639753621, ss1682747654, ss1752413942, ss1809733891, ss1938784172, ss1946577570, ss1959965669, ss2030165110, ss2158775024, ss2413282472, ss2629580683, ss2633862723, ss2704517964, ss2710952854, ss2972984362, ss3019086014, ss3022171854, ss3352776384, ss3625799471, ss3628505954, ss3631815129, ss3633268838, ss3633984226, ss3634860914, ss3635668865, ss3636556549, ss3637421056, ss3638374411, ss3640568215, ss3644796311, ss3652633407, ss3685618566, ss3743823083, ss3744205012, ss3745160746, ss3759230684, ss3772656730, ss3835927685, ss3841592346, ss3890256408, ss3940639888, ss3984758310, ss3985910166, ss5232039685 NC_000022.10:19930108:T:C NC_000022.11:19942585:T:C (self)
2227910, 39767234, 1303717, 7549, 237439930, 380211493, 7902659793, ss2246455616, ss3028920254, ss3374056851, ss3707954568, ss3725957465, ss3772082248, ss3822398587, ss3847107003, ss3983389233, ss5105102546 NC_000022.11:19942585:T:C NC_000022.11:19942585:T:C (self)
ss84952, ss5809154, ss12673693, ss24556280, ss44321933, ss65825923, ss66723507, ss67574446, ss67955598, ss69277078, ss70925845, ss71526746, ss75654303, ss79255748, ss83541994, ss84140170, ss105439098, ss122749178, ss138335162, ss154422667, ss157034291, ss159597772, ss160876808, ss172286785, ss174359358 NT_011519.10:3082258:T:C NC_000022.11:19942585:T:C (self)
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Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

15 citations for rs737866
PMID Title Author Year Journal
18663369 Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Strug LJ et al. 2010 Molecular psychiatry
18937309 Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study. Biederman J et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
19094200 Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. Rakvåg TT et al. 2008 Molecular pain
20551675 Localizing putative markers in genetic association studies by incorporating linkage disequilibrium into bayesian hierarchical models. Fridley BL et al. 2010 Human heredity
20877297 Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response. Ji Y et al. 2012 The pharmacogenomics journal
21368917 Epistasis between neurochemical gene polymorphisms and risk for ADHD. Segurado R et al. 2011 European journal of human genetics
21656904 Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. Ittiwut R et al. 2011 American journal of medical genetics. Part B, Neuropsychiatric genetics
21857968 Role of novelty seeking personality traits as mediator of the association between COMT and onset age of drug use in Chinese heroin dependent patients. Li T et al. 2011 PloS one
22021758 Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort. Nyman ES et al. 2011 BMJ open
22963930 Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent. Al-Eitan LN et al. 2012 BMC research notes
23766564 Pharmacogenetics of chronic pain and its treatment. Světlík S et al. 2013 Mediators of inflammation
25416100 Oxidative stress in susceptibility to breast cancer: study in Spanish population. Rodrigues P et al. 2014 BMC cancer
25819021 A review of pharmacogenetic studies of substance-related disorders. Jones JD et al. 2015 Drug and alcohol dependence
31744450 Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine. Abijo T et al. 2020 Current neuropharmacology
32407152 Association of <i>COMT</i> Gene Polymorphisms with Response to Methadone Maintenance Treatment Among Chinese Opioid-Dependent Patients. Duan L et al. 2020 Genetic testing and molecular biomarkers
Help

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post676+237644a