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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs699

Current Build 154

Released April 21, 2020

Organism
Homo sapiens
Position
chr1:230710048 (GRCh38.p12) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
A>G
Variation Type
SNV Single Nucleotide Variation
Frequency
A=0.451859 (113572/251344, GnomAD_exome)
G=0.453372 (86119/189952, ALFA Project)
A=0.403041 (50609/125568, TOPMED) (+ 21 more)
A=0.451568 (54768/121284, ExAC)
A=0.25972 (20440/78700, PAGE_STUDY)
A=0.42454 (13306/31342, GnomAD)
A=0.2949 (1477/5008, 1000G)
G=0.4801 (2151/4480, Estonian)
G=0.3954 (1524/3854, ALSPAC)
G=0.4113 (1525/3708, TWINSUK)
A=0.3125 (1000/3200, PharmGKB)
A=0.1973 (578/2930, KOREAN)
A=0.3023 (630/2084, HGDP_Stanford)
A=0.2680 (507/1892, HapMap)
A=0.1747 (320/1832, Korea1K)
G=0.402 (401/998, GoNL)
A=0.106 (65/612, Vietnamese)
G=0.388 (233/600, NorthernSweden)
G=0.397 (212/534, MGP)
A=0.202 (96/476, SGDP_PRJ)
G=0.375 (114/304, FINRISK)
A=0.426 (92/216, Qatari)
A=0.35 (16/46, Siberian)
G=0.33 (13/40, GENOME_DK)
Clinical Significance
Reported in ClinVar
Gene : Consequence
AGT : Missense Variant
Publications
131 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p12 chr 1 NC_000001.11:g.230710048A>G
GRCh37.p13 chr 1 NC_000001.10:g.230845794A>G
AGT RefSeqGene NG_008836.2:g.9543T>C
AGT RefSeqGene NG_008836.1:g.9543T>C
Gene: AGT, angiotensinogen (minus strand)
Molecule type Change Amino acid[Codon] SO Term
AGT transcript variant 1 NM_000029.4:c.803T>C M [ATG] > T [ACG] Coding Sequence Variant
angiotensinogen preproprotein NP_000020.1:p.Met268Thr M (Met) > T (Thr) Missense Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: G (allele ID: 33107 )
ClinVar Accession Disease Names Clinical Significance
RCV000019691.5 Hypertension, essential, susceptibility to Risk-Factor
RCV000019692.5 Preeclampsia, susceptibility to Risk-Factor
RCV000019693.5 Susceptibility to progression to renal failure in IgA nephropathy Risk-Factor
RCV000242838.1 not specified Benign
RCV000405686.1 Renal dysplasia Benign
RCV000835695.1 not provided Benign

ALFA Allele Frequency (New)
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20200227123210
Population Group Sample Size Ref Allele Alt Allele
Total Global 189952 A=0.546628 G=0.453372
European Sub 161652 A=0.578533 G=0.421467
African Sub 6652 A=0.1942 G=0.8058
African Others Sub 216 A=0.097 G=0.903
African American Sub 6436 A=0.1975 G=0.8025
Asian Sub 424 A=0.184 G=0.816
East Asian Sub 288 A=0.174 G=0.826
Other Asian Sub 136 A=0.206 G=0.794
Latin American 1 Sub 562 A=0.427 G=0.573
Latin American 2 Sub 5436 A=0.3087 G=0.6913
South Asian Sub 4902 A=0.3841 G=0.6159
Other Sub 10324 A=0.49797 G=0.50203


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
gnomAD - Exomes Global Study-wide 251344 A=0.451859 G=0.548141
gnomAD - Exomes European Sub 135306 A=0.576885 G=0.423115
gnomAD - Exomes Asian Sub 48996 A=0.29778 G=0.70222
gnomAD - Exomes American Sub 34590 A=0.28040 G=0.71960
gnomAD - Exomes African Sub 16238 A=0.15495 G=0.84505
gnomAD - Exomes Ashkenazi Jewish Sub 10078 A=0.56003 G=0.43997
gnomAD - Exomes Other Sub 6136 A=0.4998 G=0.5002
ALFA Total Global 189952 A=0.546628 G=0.453372
ALFA European Sub 161652 A=0.578533 G=0.421467
ALFA Other Sub 10324 A=0.49797 G=0.50203
ALFA African Sub 6652 A=0.1942 G=0.8058
ALFA Latin American 2 Sub 5436 A=0.3087 G=0.6913
ALFA South Asian Sub 4902 A=0.3841 G=0.6159
ALFA Latin American 1 Sub 562 A=0.427 G=0.573
ALFA Asian Sub 424 A=0.184 G=0.816
TopMed Global Study-wide 125568 A=0.403041 G=0.596959
ExAC Global Study-wide 121284 A=0.451568 G=0.548432
ExAC Europe Sub 73258 A=0.57465 G=0.42535
ExAC Asian Sub 25148 A=0.30332 G=0.69668
ExAC American Sub 11572 A=0.25838 G=0.74162
ExAC African Sub 10398 A=0.15532 G=0.84468
ExAC Other Sub 908 A=0.481 G=0.519
The PAGE Study Global Study-wide 78700 A=0.25972 G=0.74028
The PAGE Study AfricanAmerican Sub 32516 A=0.17865 G=0.82135
The PAGE Study Mexican Sub 10810 A=0.30453 G=0.69547
The PAGE Study Asian Sub 8318 A=0.1883 G=0.8117
The PAGE Study PuertoRican Sub 7918 A=0.3815 G=0.6185
The PAGE Study NativeHawaiian Sub 4534 A=0.2353 G=0.7647
The PAGE Study Cuban Sub 4230 A=0.4905 G=0.5095
The PAGE Study Dominican Sub 3828 A=0.3427 G=0.6573
The PAGE Study CentralAmerican Sub 2448 A=0.3109 G=0.6891
The PAGE Study SouthAmerican Sub 1982 A=0.3355 G=0.6645
The PAGE Study NativeAmerican Sub 1260 A=0.4373 G=0.5627
The PAGE Study SouthAsian Sub 856 A=0.375 G=0.625
gnomAD - Genomes Global Study-wide 31342 A=0.42454 G=0.57546
gnomAD - Genomes European Sub 18862 A=0.56129 G=0.43871
gnomAD - Genomes African Sub 8696 A=0.1671 G=0.8329
gnomAD - Genomes East Asian Sub 1560 A=0.1603 G=0.8397
gnomAD - Genomes Other Sub 1086 A=0.5295 G=0.4705
gnomAD - Genomes American Sub 848 A=0.323 G=0.677
gnomAD - Genomes Ashkenazi Jewish Sub 290 A=0.576 G=0.424
1000Genomes Global Study-wide 5008 A=0.2949 G=0.7051
1000Genomes African Sub 1322 A=0.0968 G=0.9032
1000Genomes East Asian Sub 1008 A=0.1468 G=0.8532
1000Genomes Europe Sub 1006 A=0.5885 G=0.4115
1000Genomes South Asian Sub 978 A=0.364 G=0.636
1000Genomes American Sub 694 A=0.365 G=0.635
Genetic variation in the Estonian population Estonian Study-wide 4480 A=0.5199 G=0.4801
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 A=0.6046 G=0.3954
UK 10K study - Twins TWIN COHORT Study-wide 3708 A=0.5887 G=0.4113
PharmGKB Aggregated Global Study-wide 3200 A=0.3125 G=0.6875
PharmGKB Aggregated PA146863313 Sub 2070 A=0.2792 G=0.7208
PharmGKB Aggregated PA146855991 Sub 1036 A=0.3755 G=0.6245
PharmGKB Aggregated PA151493465 Sub 94 A=0.35 G=0.65
KOREAN population from KRGDB KOREAN Study-wide 2930 A=0.1973 G=0.8027
HGDP-CEPH-db Supplement 1 Global Study-wide 2084 A=0.3023 G=0.6977
HGDP-CEPH-db Supplement 1 Est_Asia Sub 470 A=0.211 G=0.789
HGDP-CEPH-db Supplement 1 Central_South_Asia Sub 414 A=0.374 G=0.626
HGDP-CEPH-db Supplement 1 Middle_Est Sub 350 A=0.457 G=0.543
HGDP-CEPH-db Supplement 1 Europe Sub 320 A=0.581 G=0.419
HGDP-CEPH-db Supplement 1 Africa Sub 242 A=0.054 G=0.946
HGDP-CEPH-db Supplement 1 America Sub 216 A=0.060 G=0.940
HGDP-CEPH-db Supplement 1 Oceania Sub 72 A=0.06 G=0.94
HapMap Global Study-wide 1892 A=0.2680 G=0.7320
HapMap American Sub 770 A=0.377 G=0.623
HapMap African Sub 692 A=0.113 G=0.887
HapMap Asian Sub 254 A=0.154 G=0.846
HapMap Europe Sub 176 A=0.568 G=0.432
Korean Genome Project KOREAN Study-wide 1832 A=0.1747 G=0.8253
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 A=0.598 G=0.402
A Vietnamese Genetic Variation Database Global Study-wide 612 A=0.106 G=0.894
Northern Sweden ACPOP Study-wide 600 A=0.612 G=0.388
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 A=0.603 G=0.397
SGDP_PRJ Global Study-wide 476 A=0.202 G=0.798
FINRISK Finnish from FINRISK project Study-wide 304 A=0.625 G=0.375
Qatari Global Study-wide 216 A=0.426 G=0.574
Siberian Global Study-wide 46 A=0.35 G=0.65
The Danish reference pan genome Danish Study-wide 40 A=0.68 G=0.33
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement A= G
GRCh38.p12 chr 1 NC_000001.11:g.230710048= NC_000001.11:g.230710048A>G
GRCh37.p13 chr 1 NC_000001.10:g.230845794= NC_000001.10:g.230845794A>G
AGT RefSeqGene NG_008836.2:g.9543= NG_008836.2:g.9543T>C
AGT RefSeqGene NG_008836.1:g.9543= NG_008836.1:g.9543T>C
AGT transcript variant 1 NM_000029.4:c.803= NM_000029.4:c.803T>C
AGT transcript NM_000029.3:c.803= NM_000029.3:c.803T>C
angiotensinogen preproprotein NP_000020.1:p.Met268= NP_000020.1:p.Met268Thr
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

176 SubSNP, 24 Frequency, 6 ClinVar submissions
No Submitter Submission ID Date (Build)
1 WIAF ss704 Sep 19, 2000 (36)
2 DEBNICK ss5428 Sep 19, 2000 (52)
3 ARAVINDA ss6484 Sep 19, 2000 (52)
4 LEE ss1510443 Oct 04, 2000 (86)
5 YUSUKE ss3240877 Sep 28, 2001 (100)
6 SC_JCM ss3474289 Sep 28, 2001 (100)
7 LEE ss4404260 May 29, 2002 (106)
8 WI_SSAHASNP ss6695891 Feb 20, 2003 (111)
9 CGAP-GAI ss16264528 Feb 27, 2004 (120)
10 WIPGA ss16338660 Feb 27, 2004 (120)
11 PARC ss16338962 Feb 27, 2004 (120)
12 IMCJ-GDT ss22886629 Apr 05, 2004 (121)
13 SEQUENOM ss24795960 Sep 20, 2004 (123)
14 MGC_GENOME_DIFF ss28510655 Sep 24, 2004 (126)
15 ABI ss41315627 Mar 10, 2006 (126)
16 APPLERA_GI ss48405656 Mar 10, 2006 (126)
17 ILLUMINA ss65729138 Oct 14, 2006 (127)
18 ILLUMINA ss66689419 Nov 29, 2006 (127)
19 ILLUMINA ss67526267 Nov 29, 2006 (127)
20 ILLUMINA ss67893963 Nov 29, 2006 (127)
21 PHARMGKB_PAAR-UCHI ss68756182 May 16, 2007 (127)
22 ILLUMINA ss70900601 May 27, 2008 (130)
23 ILLUMINA ss71495837 May 16, 2007 (127)
24 ILLUMINA ss75563522 Dec 06, 2007 (129)
25 CGM_KYOTO ss76867062 Dec 06, 2007 (129)
26 SI_EXO ss76898489 Dec 06, 2007 (129)
27 ILLUMINA ss79241387 Dec 16, 2007 (130)
28 KRIBB_YJKIM ss83344277 Dec 16, 2007 (130)
29 PHARMGKB_PARC ss84151430 Dec 16, 2007 (130)
30 PHARMGKB_GERA ss84169976 Dec 16, 2007 (130)
31 HGSV ss84733296 Dec 16, 2007 (130)
32 RSG_UW ss86211304 Mar 23, 2008 (129)
33 RSG_JCVI ss86215597 Mar 23, 2008 (129)
34 CANCER-GENOME ss86342331 Mar 23, 2008 (129)
35 BCMHGSC_JDW ss88003508 Mar 23, 2008 (129)
36 CNG ss95211226 Mar 25, 2008 (129)
37 HUMANGENOME_JCVI ss99294632 Feb 06, 2009 (130)
38 BGI ss102830762 Dec 01, 2009 (131)
39 1000GENOMES ss109021205 Jan 23, 2009 (130)
40 1000GENOMES ss111914188 Jan 25, 2009 (130)
41 ILLUMINA-UK ss119241034 Feb 15, 2009 (130)
42 ILLUMINA ss120036571 Dec 01, 2009 (131)
43 ILLUMINA ss122663428 Dec 01, 2009 (131)
44 ENSEMBL ss139040775 Dec 01, 2009 (131)
45 ILLUMINA ss154396826 Dec 01, 2009 (131)
46 GMI ss156402016 Dec 01, 2009 (131)
47 ILLUMINA ss159572250 Dec 01, 2009 (131)
48 SEATTLESEQ ss159700825 Dec 01, 2009 (131)
49 ILLUMINA ss160834104 Dec 01, 2009 (131)
50 COMPLETE_GENOMICS ss167558898 Jul 04, 2010 (132)
51 ILLUMINA ss172228947 Jul 04, 2010 (132)
52 ILLUMINA ss174195550 Jul 04, 2010 (132)
53 BUSHMAN ss199729303 Jul 04, 2010 (132)
54 1000GENOMES ss218933413 Jul 14, 2010 (132)
55 1000GENOMES ss230940960 Jul 14, 2010 (132)
56 1000GENOMES ss238547516 Jul 15, 2010 (132)
57 ILLUMINA ss244307360 Jul 04, 2010 (132)
58 BL ss253884106 May 09, 2011 (134)
59 RSG_JCVI ss262866345 May 09, 2011 (134)
60 OMIM-CURATED-RECORDS ss275513909 Nov 22, 2010 (133)
61 GMI ss276256126 May 04, 2012 (137)
62 PJP ss290753202 May 09, 2011 (134)
63 NHLBI-ESP ss342035784 May 09, 2011 (134)
64 ILLUMINA ss481424313 May 04, 2012 (137)
65 ILLUMINA ss481451642 May 04, 2012 (137)
66 ILLUMINA ss482431839 Sep 08, 2015 (146)
67 ILLUMINA ss485507166 May 04, 2012 (137)
68 1000GENOMES ss489796248 May 04, 2012 (137)
69 EXOME_CHIP ss491312311 May 04, 2012 (137)
70 CLINSEQ_SNP ss491617262 May 04, 2012 (137)
71 ILLUMINA ss537419439 Sep 08, 2015 (146)
72 SSMP ss648772932 Apr 25, 2013 (138)
73 ILLUMINA ss778588039 Sep 08, 2015 (146)
74 ILLUMINA ss780759502 Sep 08, 2015 (146)
75 ILLUMINA ss783199131 Sep 08, 2015 (146)
76 ILLUMINA ss783438312 Sep 08, 2015 (146)
77 ILLUMINA ss784154108 Sep 08, 2015 (146)
78 ILLUMINA ss825571905 Apr 01, 2015 (144)
79 ILLUMINA ss832459084 Sep 08, 2015 (146)
80 ILLUMINA ss833083349 Jul 12, 2019 (153)
81 ILLUMINA ss834045208 Sep 08, 2015 (146)
82 EVA-GONL ss976246001 Aug 21, 2014 (142)
83 JMKIDD_LAB ss1067433170 Aug 21, 2014 (142)
84 JMKIDD_LAB ss1068678314 Aug 21, 2014 (142)
85 1000GENOMES ss1295034919 Aug 21, 2014 (142)
86 DDI ss1426140698 Apr 01, 2015 (144)
87 EVA_GENOME_DK ss1574742361 Apr 01, 2015 (144)
88 EVA_FINRISK ss1584015822 Apr 01, 2015 (144)
89 EVA_UK10K_ALSPAC ss1602344742 Apr 01, 2015 (144)
90 EVA_UK10K_TWINSUK ss1645338775 Apr 01, 2015 (144)
91 EVA_EXAC ss1686106090 Apr 01, 2015 (144)
92 EVA_MGP ss1710947378 Apr 01, 2015 (144)
93 EVA_SVP ss1712412874 Apr 01, 2015 (144)
94 ILLUMINA ss1751904327 Sep 08, 2015 (146)
95 ILLUMINA ss1751904328 Sep 08, 2015 (146)
96 ILLUMINA ss1917743741 Feb 12, 2016 (147)
97 WEILL_CORNELL_DGM ss1919467681 Feb 12, 2016 (147)
98 ILLUMINA ss1946026293 Feb 12, 2016 (147)
99 ILLUMINA ss1946026294 Feb 12, 2016 (147)
100 ILLUMINA ss1958366161 Feb 12, 2016 (147)
101 ILLUMINA ss1958366162 Feb 12, 2016 (147)
102 GENOMED ss1966996816 Jul 19, 2016 (147)
103 JJLAB ss2020259070 Sep 14, 2016 (149)
104 ILLUMINA ss2094786875 Dec 20, 2016 (150)
105 ILLUMINA ss2095002557 Dec 20, 2016 (150)
106 USC_VALOUEV ss2148294810 Dec 20, 2016 (150)
107 HUMAN_LONGEVITY ss2170880478 Dec 20, 2016 (150)
108 TOPMED ss2333529217 Dec 20, 2016 (150)
109 SYSTEMSBIOZJU ss2624641481 Nov 08, 2017 (151)
110 ILLUMINA ss2632641552 Nov 08, 2017 (151)
111 ILLUMINA ss2635008215 Nov 08, 2017 (151)
112 GRF ss2698294649 Nov 08, 2017 (151)
113 ILLUMINA ss2710696776 Nov 08, 2017 (151)
114 GNOMAD ss2732354723 Nov 08, 2017 (151)
115 GNOMAD ss2746586389 Nov 08, 2017 (151)
116 GNOMAD ss2767311573 Nov 08, 2017 (151)
117 AFFY ss2984897294 Nov 08, 2017 (151)
118 AFFY ss2985540500 Nov 08, 2017 (151)
119 SWEGEN ss2988609550 Nov 08, 2017 (151)
120 ILLUMINA ss3021190151 Nov 08, 2017 (151)
121 ILLUMINA ss3021190152 Nov 08, 2017 (151)
122 EVA_SAMSUNG_MC ss3023057694 Nov 08, 2017 (151)
123 BIOINF_KMB_FNS_UNIBA ss3023890141 Nov 08, 2017 (151)
124 TOPMED ss3105901501 Nov 08, 2017 (151)
125 CSHL ss3343956717 Nov 08, 2017 (151)
126 ILLUMINA ss3625568540 Oct 11, 2018 (152)
127 ILLUMINA ss3626330637 Oct 11, 2018 (152)
128 ILLUMINA ss3626330638 Oct 11, 2018 (152)
129 ILLUMINA ss3630670731 Oct 11, 2018 (152)
130 ILLUMINA ss3632929023 Oct 11, 2018 (152)
131 ILLUMINA ss3633625255 Oct 11, 2018 (152)
132 ILLUMINA ss3634377984 Oct 11, 2018 (152)
133 ILLUMINA ss3634377985 Oct 11, 2018 (152)
134 ILLUMINA ss3635318268 Oct 11, 2018 (152)
135 ILLUMINA ss3636056984 Oct 11, 2018 (152)
136 ILLUMINA ss3637068824 Oct 11, 2018 (152)
137 ILLUMINA ss3637819731 Oct 11, 2018 (152)
138 ILLUMINA ss3638924889 Oct 11, 2018 (152)
139 ILLUMINA ss3639461432 Oct 11, 2018 (152)
140 ILLUMINA ss3640085337 Oct 11, 2018 (152)
141 ILLUMINA ss3640085338 Oct 11, 2018 (152)
142 ILLUMINA ss3642825676 Oct 11, 2018 (152)
143 ILLUMINA ss3644522291 Oct 11, 2018 (152)
144 ILLUMINA ss3644522292 Oct 11, 2018 (152)
145 OMUKHERJEE_ADBS ss3646255195 Oct 11, 2018 (152)
146 URBANLAB ss3646907486 Oct 11, 2018 (152)
147 ILLUMINA ss3651535804 Oct 11, 2018 (152)
148 ILLUMINA ss3651535805 Oct 11, 2018 (152)
149 ILLUMINA ss3653667430 Oct 11, 2018 (152)
150 EGCUT_WGS ss3656567973 Jul 12, 2019 (153)
151 EVA_DECODE ss3688819192 Jul 12, 2019 (153)
152 ILLUMINA ss3725114460 Jul 12, 2019 (153)
153 ACPOP ss3727946110 Jul 12, 2019 (153)
154 ILLUMINA ss3744062215 Jul 12, 2019 (153)
155 ILLUMINA ss3744361560 Jul 12, 2019 (153)
156 ILLUMINA ss3744678831 Jul 12, 2019 (153)
157 ILLUMINA ss3744678832 Jul 12, 2019 (153)
158 EVA ss3747457633 Jul 12, 2019 (153)
159 PAGE_CC ss3770878819 Jul 12, 2019 (153)
160 ILLUMINA ss3772179704 Jul 12, 2019 (153)
161 ILLUMINA ss3772179705 Jul 12, 2019 (153)
162 PACBIO ss3783713139 Jul 12, 2019 (153)
163 PACBIO ss3789321126 Jul 12, 2019 (153)
164 PACBIO ss3794193540 Jul 12, 2019 (153)
165 KHV_HUMAN_GENOMES ss3800459334 Jul 12, 2019 (153)
166 EVA ss3823726644 Apr 25, 2020 (154)
167 EVA ss3825519031 Apr 25, 2020 (154)
168 EVA ss3825535982 Apr 25, 2020 (154)
169 EVA ss3825590662 Apr 25, 2020 (154)
170 EVA ss3826693714 Apr 25, 2020 (154)
171 EVA ss3836748599 Apr 25, 2020 (154)
172 EVA ss3842161010 Apr 25, 2020 (154)
173 HGDP ss3847366529 Apr 25, 2020 (154)
174 SGDP_PRJ ss3851098710 Apr 25, 2020 (154)
175 KRGDB ss3896445005 Apr 25, 2020 (154)
176 KOGIC ss3946693229 Apr 25, 2020 (154)
177 1000Genomes NC_000001.10 - 230845794 Oct 11, 2018 (152)
178 The Avon Longitudinal Study of Parents and Children NC_000001.10 - 230845794 Oct 11, 2018 (152)
179 Genetic variation in the Estonian population NC_000001.10 - 230845794 Oct 11, 2018 (152)
180 ExAC NC_000001.10 - 230845794 Oct 11, 2018 (152)
181 FINRISK NC_000001.10 - 230845794 Apr 25, 2020 (154)
182 The Danish reference pan genome NC_000001.10 - 230845794 Apr 25, 2020 (154)
183 gnomAD - Genomes NC_000001.10 - 230845794 Jul 12, 2019 (153)
184 gnomAD - Exomes NC_000001.10 - 230845794 Jul 12, 2019 (153)
185 Genome of the Netherlands Release 5 NC_000001.10 - 230845794 Apr 25, 2020 (154)
186 HGDP-CEPH-db Supplement 1 NC_000001.9 - 228912417 Apr 25, 2020 (154)
187 HapMap NC_000001.11 - 230710048 Apr 25, 2020 (154)
188 KOREAN population from KRGDB NC_000001.10 - 230845794 Apr 25, 2020 (154)
189 Korean Genome Project NC_000001.11 - 230710048 Apr 25, 2020 (154)
190 Medical Genome Project healthy controls from Spanish population NC_000001.10 - 230845794 Apr 25, 2020 (154)
191 Northern Sweden NC_000001.10 - 230845794 Jul 12, 2019 (153)
192 The PAGE Study NC_000001.11 - 230710048 Jul 12, 2019 (153)
193 PharmGKB Aggregated NC_000001.11 - 230710048 Apr 25, 2020 (154)
194 Qatari NC_000001.10 - 230845794 Apr 25, 2020 (154)
195 SGDP_PRJ NC_000001.10 - 230845794 Apr 25, 2020 (154)
196 Siberian NC_000001.10 - 230845794 Apr 25, 2020 (154)
197 TopMed NC_000001.11 - 230710048 Oct 11, 2018 (152)
198 UK 10K study - Twins NC_000001.10 - 230845794 Oct 11, 2018 (152)
199 A Vietnamese Genetic Variation Database NC_000001.10 - 230845794 Jul 12, 2019 (153)
200 dbGaP Population Frequency Project NC_000001.11 - 230710048 Apr 25, 2020 (154)
201 ClinVar RCV000019691.5 Jul 12, 2019 (153)
202 ClinVar RCV000019692.5 Jul 12, 2019 (153)
203 ClinVar RCV000019693.5 Jul 12, 2019 (153)
204 ClinVar RCV000242838.1 Oct 11, 2018 (152)
205 ClinVar RCV000405686.1 Oct 11, 2018 (152)
206 ClinVar RCV000835695.1 Apr 25, 2020 (154)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs4714 Jan 18, 2001 (92)
rs3182295 Jul 03, 2002 (106)
rs17856353 Mar 10, 2006 (126)
rs61617185 May 27, 2008 (130)
rs386606420 Aug 06, 2014 (136)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss84733296, ss3638924889, ss3639461432 NC_000001.8:227152528:A:G NC_000001.11:230710047:A:G (self)
44421, ss88003508, ss109021205, ss111914188, ss119241034, ss167558898, ss199729303, ss253884106, ss276256126, ss290753202, ss481424313, ss491617262, ss825571905, ss1712412874, ss2635008215, ss3642825676, ss3847366529 NC_000001.9:228912416:A:G NC_000001.11:230710047:A:G (self)
5903401, 3264095, 2306221, 5346390, 12283, 1925477, 16131712, 1392291, 1426376, 3622399, 64130, 1230975, 1509611, 3115690, 811164, 3264095, 709996, ss218933413, ss230940960, ss238547516, ss342035784, ss481451642, ss482431839, ss485507166, ss489796248, ss491312311, ss537419439, ss648772932, ss778588039, ss780759502, ss783199131, ss783438312, ss784154108, ss832459084, ss833083349, ss834045208, ss976246001, ss1067433170, ss1068678314, ss1295034919, ss1426140698, ss1574742361, ss1584015822, ss1602344742, ss1645338775, ss1686106090, ss1710947378, ss1751904327, ss1751904328, ss1917743741, ss1919467681, ss1946026293, ss1946026294, ss1958366161, ss1958366162, ss1966996816, ss2020259070, ss2094786875, ss2095002557, ss2148294810, ss2333529217, ss2624641481, ss2632641552, ss2698294649, ss2710696776, ss2732354723, ss2746586389, ss2767311573, ss2984897294, ss2985540500, ss2988609550, ss3021190151, ss3021190152, ss3023057694, ss3343956717, ss3625568540, ss3626330637, ss3626330638, ss3630670731, ss3632929023, ss3633625255, ss3634377984, ss3634377985, ss3635318268, ss3636056984, ss3637068824, ss3637819731, ss3640085337, ss3640085338, ss3644522291, ss3644522292, ss3646255195, ss3651535804, ss3651535805, ss3653667430, ss3656567973, ss3727946110, ss3744062215, ss3744361560, ss3744678831, ss3744678832, ss3747457633, ss3772179704, ss3772179705, ss3783713139, ss3789321126, ss3794193540, ss3823726644, ss3825519031, ss3825535982, ss3825590662, ss3826693714, ss3836748599, ss3851098710, ss3896445005 NC_000001.10:230845793:A:G NC_000001.11:230710047:A:G (self)
RCV000019691.5, RCV000019692.5, RCV000019693.5, RCV000242838.1, RCV000405686.1, RCV000835695.1, 288059, 3071230, 100288, 899, 31778654, 535493226, ss275513909, ss2170880478, ss3023890141, ss3105901501, ss3646907486, ss3688819192, ss3725114460, ss3770878819, ss3800459334, ss3842161010, ss3946693229 NC_000001.11:230710047:A:G NC_000001.11:230710047:A:G (self)
ss76898489 NT_004559.13:7047947:A:G NC_000001.11:230710047:A:G (self)
ss704, ss5428, ss6484, ss1510443, ss3240877, ss3474289, ss4404260, ss6695891, ss16264528, ss16338660, ss16338962, ss22886629, ss24795960, ss28510655, ss41315627, ss48405656, ss65729138, ss66689419, ss67526267, ss67893963, ss68756182, ss70900601, ss71495837, ss75563522, ss76867062, ss79241387, ss83344277, ss84151430, ss84169976, ss86211304, ss86215597, ss86342331, ss95211226, ss99294632, ss102830762, ss120036571, ss122663428, ss139040775, ss154396826, ss156402016, ss159572250, ss159700825, ss160834104, ss172228947, ss174195550, ss244307360, ss262866345 NT_167186.1:24363572:A:G NC_000001.11:230710047:A:G (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

131 citations for rs699
PMID Title Author Year Journal
1394429 Molecular basis of human hypertension: role of angiotensinogen. Jeunemaitre X et al. 1992 Cell
7649545 Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota. Fornage M et al. 1995 Human genetics
7883995 The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children. Bloem LJ et al. 1995 The Journal of clinical investigation
8348146 Angiotensinogen: a candidate gene involved in preeclampsia? Arngrímsson R et al. 1993 Nature genetics
8513325 A molecular variant of angiotensinogen associated with preeclampsia. Ward K et al. 1993 Nature genetics
8518804 Rapid detection of the hypertension-associated Met235-->Thr allele of the human angiotensinogen gene. Russ AP et al. 1993 Human molecular genetics
9259580 Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. Pei Y et al. 1997 The Journal of clinical investigation
9421481 Angiotensinogen gene and hypertension in Chinese. Niu T et al. 1998 The Journal of clinical investigation
9831339 Associations of angiotensinogen gene mutations with hypertension and myocardial infarction in a gulf population. Frossard PM et al. 1998 Clinical genetics
16059745 The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia. Hillermann R et al. 2005 Journal of human genetics
18069999 Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study. Conen D et al. 2008 Journal of internal medicine
18248681 Prevalence of common disease-associated variants in Asian Indians. Pemberton TJ et al. 2008 BMC genetics
18279468 Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure. Zakrzewski-Jakubiak M et al. 2008 British journal of clinical pharmacology
18513389 New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. Penco S et al. 2008 BMC bioinformatics
18603647 Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response. Simoni M et al. 2008 Human reproduction update
18637188 RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population. Freitas AI et al. 2008 BMC cardiovascular disorders
18653189 Interaction of gender, hypertension, and the angiotensinogen gene haplotypes on the risk of coronary artery disease in a large angiographic cohort. Tsai CT et al. 2009 Atherosclerosis
18698212 Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study. Conen D et al. 2008 Journal of hypertension
18953568 Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. Schoenhard JA et al. 2008 Human genetics
19108684 ACE variants interact with the RAS pathway to confer risk and protection against type 2 diabetic nephropathy. Ahluwalia TS et al. 2009 DNA and cell biology
19131662 A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Wang X et al. 2009 Stroke
19263529 Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. Zee RY et al. 2009 Clinica chimica acta; international journal of clinical chemistry
19330901 Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. Conen D et al. 2009 Journal of hypertension
19559392 A candidate gene association study of 77 polymorphisms in migraine. Schürks M et al. 2009 The journal of pain
19770777 Genotype-phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes. Watkins WS et al. 2010 Journal of hypertension
19932491 Angiotensinogen polymorphisms and acquired atrial fibrillation in Chinese. Wang QS et al. 2010 Journal of electrocardiology
20029521 The C allele of the AGT Met235Thr polymorphism is associated with power sports performance. Gomez-Gallego F et al. 2009 Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
20047954 Variants in blood pressure genes and the risk of renal cell carcinoma. Andreotti G et al. 2010 Carcinogenesis
20061926 Randomized controlled trial: lisinopril reduces proteinuria, ammonia, and renal polypeptide tubular catabolism in patients with chronic allograft nephropathy. Amara AB et al. 2010 Transplantation
20185782 Renin angiotensin system gene polymorphisms and cerebral blood flow regulation: the MOBILIZE Boston study. Hajjar I et al. 2010 Stroke
20486282 Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure. Gu D et al. 2010 Journal of hypertension
20570668 Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau. Buroker NE et al. 2010 Clinica chimica acta; international journal of clinical chemistry
20577119 Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study. Irvin MR et al. 2010 Journal of hypertension
20592051 Interactions among related genes of renin-angiotensin system associated with type 2 diabetes. Yang JK et al. 2010 Diabetes care
20811292 Genetic variants in the renin-angiotensin system and blood pressure reactions to the cold pressor test. Wang L et al. 2010 Journal of hypertension
20981351 Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study. Sugimoto K et al. 2010 International journal of hypertension
21056700 Lack of replication in polymorphisms reported to be associated with atrial fibrillation. Sinner MF et al. 2011 Heart rhythm
21058046 Genetics of salt-sensitive hypertension. Sanada H et al. 2011 Current hypertension reports
21127830 Genetic associations in diabetic nephropathy: a meta-analysis. Mooyaart AL et al. 2011 Diabetologia
21146954 Genes and abdominal aortic aneurysm. Hinterseher I et al. 2011 Annals of vascular surgery
21261619 Genetic variation in renin predicts the effects of thiazide diuretics. Huang CC et al. 2011 European journal of clinical investigation
21304999 Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. Penrod NM et al. 2011 PloS one
21306748 The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach. Underwood PC et al. 2011 Metabolism
21438754 Gene variation in resistant hypertension: multilocus analysis of the angiotensin 1-converting enzyme, angiotensinogen, and endothelial nitric oxide synthase genes. Yugar-Toledo JC et al. 2011 DNA and cell biology
21444836 Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Johnson AD et al. 2011 Hypertension (Dallas, Tex.
21467728 Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Wakai K et al. 2011 Journal of epidemiology
21515823 Genetic predictors for stroke in children with sickle cell anemia. Flanagan JM et al. 2011 Blood
21533139 Predicting diabetic nephropathy using a multifactorial genetic model. Blech I et al. 2011 PloS one
21540342 Genes and elite athletes: a roadmap for future research. Eynon N et al. 2011 The Journal of physiology
21573014 Genes involved in vasoconstriction and vasodilation system affect salt-sensitive hypertension. Citterio L et al. 2011 PloS one
21681796 Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Fornage M et al. 2011 Annals of neurology
21894447 Are centenarians genetically predisposed to lower disease risk? Ruiz JR et al. 2012 Age (Dordrecht, Netherlands)
21919968 Validation of genetic variants associated with early acute rejection in kidney allograft transplantation. Oetting WS et al. 2012 Clinical transplantation
21988197 Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis. Ono M et al. 2011 Hepatology research
22099458 Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development. Singh KK et al. 2011 Neuron
22100073 Blood pressure loci identified with a gene-centric array. Johnson T et al. 2011 American journal of human genetics
22531885 Revising the M235T polymorphism position for the AGT gene and reporting a modifying variant in the Brazilian population with potential cardiac and neural impact. Lemos RR et al. 2012 Journal of molecular neuroscience
22569109 The role of renin-angiotensin-aldosterone system polymorphisms in phenotypic expression of MYBPC3-related hypertrophic cardiomyopathy. Kolder IC et al. 2012 European journal of human genetics
22817530 Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study. Jimenez-Sousa MA et al. 2012 BMC medical genetics
22858200 Angiotensinogen gene polymorphisms and food-intake behavior in young, normal female subjects in Japan. Sasaki M et al. 2013 Nutrition (Burbank, Los Angeles County, Calif.)
23021345 Gene-diet interactions on plasma lipid levels in the Inuit population. Rudkowska I et al. 2013 The British journal of nutrition
23036011 Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases. Huhn S et al. 2012 BMC medical genetics
23132613 Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis. Staines-Urias E et al. 2012 International journal of epidemiology
23133444 Genetic variation in CYP17A1 is associated with arterial stiffness in diabetic subjects. Yang SJ et al. 2012 Experimental diabetes research
23205182 A genome-wide association study of variations in maternal cardiometabolic genes and risk of placental abruption. Moore A et al. 2012 International journal of molecular epidemiology and genetics
23251296 Assessment of two missense polymorphisms (rs4762 and rs699) of the angiotensinogen gene and stroke. Park HK et al. 2013 Experimental and therapeutic medicine
23287839 Association of rs699 (M235T) polymorphism in the AGT gene with power but not endurance athlete status. Zarębska A et al. 2013 Journal of strength and conditioning research
23333443 Analysis of polymorphisms and haplotypes in genes associated with vascular tone, hypertension and oxidative stress in Mexican-Mestizo women with severe preeclampsia. Coral-Vázquez RM et al. 2013 Clinical biochemistry
23354977 Human loci involved in drug biotransformation: worldwide genetic variation, population structure, and pharmacogenetic implications. Maisano Delser P et al. 2013 Human genetics
23497168 Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population. Rudkowska I et al. 2013 Nutrition & metabolism
23681449 Genes for elite power and sprint performance: ACTN3 leads the way. Eynon N et al. 2013 Sports medicine (Auckland, N.Z.)
23716723 The relationship between angiotensinogen gene polymorphisms and essential hypertension in a Northern Han Chinese population. Li H et al. 2014 Angiology
24452035 ACE insertion/deletion polymorphism (rs1799752) modifies the renoprotective effect of renin-angiotensin system blockade in patients with IgA nephropathy. Teranishi J et al. 2015 Journal of the renin-angiotensin-aldosterone system
24622918 Renin-angiotensin system genetic polymorphisms and brain white matter lesions in older Australians. Assareh AA et al. 2014 American journal of hypertension
24722536 Relationship of renin-angiotensin-aldosterone system polymorphisms and phenotypes to mortality in Chinese coronary atherosclerosis patients. Jia EZ et al. 2014 Scientific reports
24737640 Genetic variants of ACE (Insertion/Deletion) and AGT (M268T) genes in patients with diabetes and nephropathy. Shaikh R et al. 2014 Journal of the renin-angiotensin-aldosterone system
25020710
25474356 Highly significant association between two common single nucleotide polymorphisms in CORIN gene and preeclampsia in Caucasian women. Stepanian A et al. 2014 PloS one
25512783 Association of genetic variants with diabetic nephropathy. Rizvi S et al. 2014 World journal of diabetes
25683681 Positive Association of D Allele of ACE Gene With High Altitude Pulmonary Edema in Indian Population. Bhagi S et al. 2015 Wilderness & environmental medicine
25723521 Polymorphisms of renin-angiotensin-aldosterone system gene in chinese han patients with nonfamilial atrial fibrillation. Zhao LQ et al. 2015 PloS one
25741868 Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Richards S et al. 2015 Genetics in medicine
26102248 The C4280A (rs5705) gene polymorphism of the renin (REN) gene is associated with risk of developing coronary artery disease, but not with restenosis after coronary stenting. Fragoso JM et al. 2015 Experimental and molecular pathology
26283679 Correlation between renin-angiotensin system gene polymorphisms and essential hypertension in the Chinese Yi ethnic group. Yang YL et al. 2015 Journal of the renin-angiotensin-aldosterone system
26318936 Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition. Salminen LE et al. 2016 Behavioural brain research
26335431 Altered erythrocyte membrane protein composition mirrors pleiotropic effects of hypertension susceptibility genes and disease pathogenesis. Polonikov AV et al. 2015 Journal of hypertension
26509357 Genetic variants in the renin-angiotensin system predict response to bevacizumab in cancer patients. Moreno-Muñoz D et al. 2015 European journal of clinical investigation
26588355 Lack of Association Between Polymorphisms in AGT and ATR1 and IgA Nephropathy in a Chinese Population. Gao J et al. 2015 Genetic testing and molecular biomarkers
26621708 Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. Schwarz F et al. 2016 Proceedings of the National Academy of Sciences of the United States of America
26627480 Genetic predisposition to acute kidney injury--a systematic review. Vilander LM et al. 2015 BMC nephrology
26818744 Lead exposure increases blood pressure by increasing angiotensinogen expression. Jiao J et al. 2016 Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering
26819062 Characterizing redescriptions using persistent homology to isolate genetic pathways contributing to pathogenesis. Platt DE et al. 2016 BMC systems biology
26824906 No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes. Rankinen T et al. 2016 PloS one
26933222 Alzheimer's disease CD33 rs3865444 variant does not contribute to cognitive performance. Liu G et al. 2016 Proceedings of the National Academy of Sciences of the United States of America
27068935 Renin-angiotensin system gene polymorphisms and endometrial cancer. Pringle KG et al. 2016 Endocrine connections
27274104 A genetic-based algorithm for personalized resistance training. Jones N et al. 2016 Biology of sport
27342049 AGTR1 rs3772622 gene polymorphism increase the risk of nonalcoholic fatty liver disease patients suffer coronary artery disease in Northern Chinese Han population. Liu Y et al. 2016 Lipids in health and disease
27348238 Association Between Gene Polymorphisms on Chromosome 1 and Susceptibility to Pre-Eclampsia: An Updated Meta-Analysis. Zhang G et al. 2016 Medical science monitor
27380726 Lack of association between genotype score and sprint/power performance in the Japanese population. Miyamoto-Mikami E et al. 2017 Journal of science and medicine in sport
27454254 Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015. 2016 BMC genomics
27480094 Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers. Imaizumi T et al. 2017 Clinical and experimental nephrology
27508809
27584680 Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study. Ding N et al. 2016 PloS one
27616475 Gene variants as risk factors for gastroschisis. Padula AM et al. 2016 American journal of medical genetics. Part A
27940662 Deep-targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans. Pescatello LS et al. 2016 Physiological reports
28361007 Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population. Purkait P et al. 2017 Clinical hypertension
28488548 Angiotensinogen (AGT) gene missense polymorphisms (rs699 and rs4762) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus. Makuc J et al. 2017 Bosnian journal of basic medical sciences
28605058 Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia. Ward KM et al. 2017 Pharmacotherapy
28666769 Nine genetic polymorphisms associated with power athlete status - A Meta-Analysis. Weyerstraß J et al. 2018 Journal of science and medicine in sport
28690685 Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study. Muñoz AM et al. 2017 Genes & nutrition
28770234 SNPs, linkage disequilibrium, and chronic mountain sickness in Tibetan Chinese. Buroker NE et al. 2017 Hypoxia (Auckland, N.Z.)
28828324 Simultaneous Genotyping of the rs4762 and rs699 Polymorphisms in Angiotensinogen Gene and Correlation with Iranian CAD Patients with Novel Hexa-primer ARMS-PCR. Khatami M et al. 2017 Iranian journal of public health
28881807 Associations of high altitude polycythemia with polymorphisms in <i>EPHA2</i> and <i>AGT</i> in Chinese Han and Tibetan populations. Liu L et al. 2017 Oncotarget
28903744 Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents. Simonyte S et al. 2017 BMC medical genetics
29057680 The association of renin-angiotensinogen system genes polymorphisms and idiopathic recurrent pregnancy loss. Heidari MM et al. 2019 Human fertility (Cambridge, England)
29520984 Genetic factors contributing to hypertension in African-based populations: A systematic review and meta-analysis. Yako YY et al. 2018 Journal of clinical hypertension (Greenwich, Conn.)
29578435 [THE ROLE OF MARKER FIBROSIS ST2 AND ANGIOTENZINOGEN GENE POLYMORPHISM IN HEART FAILURE PROGRESSING IN PATIENTS WITH TYPE 2 DIABETES MELLITUS]. Rudyk I et al. 2018 Georgian medical news
29627490 Genetically determined enlargement of carotid body evaluated using computed angiotomography. Jaźwiec P et al. 2018 Respiratory physiology & neurobiology
29972410 Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants. Pereira A et al. 2018 Arquivos brasileiros de cardiologia
30295198 [Left Ventricular Myocardial Hypertrophy as a Result of Arterial Hypertension Among Mountain Shoria Population. The Role of Genetic Polymorphism]. Barbarash OL et al. 2018 Kardiologiia
30387422 [Genetic Polymorphisms Associated with the Onset of Arterial Hypertension in a Portuguese Population]. Sousa AC et al. 2018 Acta medica portuguesa
30409984 Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics. John SE et al. 2018 Scientific reports
30571812 Additional value of a combined genetic risk score to standard cardiovascular stratification. Pereira A et al. 2018 Genetics and molecular biology
30719178 An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease. Liu Y et al. 2019 Disease markers
31048445 Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis. Smyth LJ et al. 2019 BMJ open
31090375 Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya. Mulerova ТА et al. 2019 Terapevticheskii arkhiv
31343553 A Genome-Wide Association Study of Sprint Performance in Elite Youth Football Players. Pickering C et al. 2019 Journal of strength and conditioning research
31396257 The Associations of <i>PMF1</i>, <i>ICAM1</i>, <i>AGT</i>, <i>TRIM65</i>, <i>FBF1</i>, and <i>ACOX1</i> Variants With Leukoaraiosis in Chinese Population. Huang WQ et al. 2019 Frontiers in genetics
31511791 Contribution of Four Polymorphisms in Renin-Angiotensin-Aldosterone-Related Genes to Hypertension in a Thai Population. Charoen P et al. 2019 International journal of hypertension
31560448 Effect of Genetic and Nongenetic Factors on the Clinical Response to Mineralocorticoid Receptor Antagonist Therapy in Egyptians with Heart Failure. Sarhan NM et al. 2020 Clinical and translational science
31858452 AGT rs699 and AGTR1 rs5186 gene variants are associated with cardiovascular-related phenotypes in atherosclerotic peripheral arterial obstructive disease. Junusbekov Y et al. 2020 Irish journal of medical science
Help

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post536+f5d31d6