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dbSNP Short Genetic Variations

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs659366

Current Build 153

Released July 9, 2019

Organism
Homo sapiens
Position
chr11:73983709 (GRCh38.p12) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
C>T
Variation Type
SNV Single Nucleotide Variation
Frequency
T=0.40192 (50468/125568, TOPMED)
T=0.4486 (35298/78682, PAGE_STUDY)
T=0.4019 (12590/31330, GnomAD) (+ 6 more)
T=0.409 (2048/5008, 1000G)
T=0.389 (1744/4480, Estonian)
T=0.379 (1461/3854, ALSPAC)
T=0.374 (1385/3708, TWINSUK)
T=0.42 (253/600, NorthernSweden)
T=0.33 (71/212, Vietnamese)
Clinical Significance
Reported in ClinVar
Gene : Consequence
UCP2 : 2KB Upstream Variant
Publications
50 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p12 chr 11 NC_000011.10:g.73983709C>T
GRCh37.p13 chr 11 NC_000011.9:g.73694754C>T
UCP2 RefSeqGene NG_011478.1:g.4136G>A
Gene: UCP2, uncoupling protein 2 (minus strand) : 2KB Upstream Variant
Molecule type Change Amino acid[Codon] SO Term
UCP2 transcript NM_003355.2:c. N/A Upstream Transcript Variant
UCP2 transcript variant X1 XM_024448674.1:c. N/A Upstream Transcript Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: T (allele ID: 22904 )
ClinVar Accession Disease Names Clinical Significance
RCV000023142.3 Body mass index quantitative trait locus 4 Risk-Factor
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Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 125568 C=0.59808 T=0.40192
The PAGE Study Global Study-wide 78682 C=0.5514 T=0.4486
The PAGE Study AfricanAmerican Sub 32506 C=0.5474 T=0.4526
The PAGE Study Mexican Sub 10810 C=0.5537 T=0.4463
The PAGE Study Asian Sub 8314 C=0.534 T=0.466
The PAGE Study PuertoRican Sub 7916 C=0.561 T=0.439
The PAGE Study NativeHawaiian Sub 4532 C=0.525 T=0.475
The PAGE Study Cuban Sub 4230 C=0.609 T=0.391
The PAGE Study Dominican Sub 3828 C=0.551 T=0.449
The PAGE Study CentralAmerican Sub 2450 C=0.555 T=0.445
The PAGE Study SouthAmerican Sub 1982 C=0.529 T=0.471
The PAGE Study NativeAmerican Sub 1258 C=0.572 T=0.428
The PAGE Study SouthAsian Sub 856 C=0.62 T=0.38
gnomAD - Genomes Global Study-wide 31330 C=0.5981 T=0.4019
gnomAD - Genomes European Sub 18862 C=0.6212 T=0.3788
gnomAD - Genomes African Sub 8696 C=0.550 T=0.450
gnomAD - Genomes East Asian Sub 1552 C=0.598 T=0.402
gnomAD - Genomes Other Sub 1086 C=0.605 T=0.395
gnomAD - Genomes American Sub 844 C=0.54 T=0.46
gnomAD - Genomes Ashkenazi Jewish Sub 290 C=0.68 T=0.32
1000Genomes Global Study-wide 5008 C=0.591 T=0.409
1000Genomes African Sub 1322 C=0.546 T=0.454
1000Genomes East Asian Sub 1008 C=0.579 T=0.421
1000Genomes Europe Sub 1006 C=0.635 T=0.365
1000Genomes South Asian Sub 978 C=0.63 T=0.37
1000Genomes American Sub 694 C=0.58 T=0.42
Genetic variation in the Estonian population Estonian Study-wide 4480 C=0.611 T=0.389
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 C=0.621 T=0.379
UK 10K study - Twins TWIN COHORT Study-wide 3708 C=0.626 T=0.374
Northern Sweden ACPOP Study-wide 600 C=0.58 T=0.42
A Vietnamese Genetic Variation Database Global Study-wide 212 C=0.67 T=0.33
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement C= T Note
GRCh38.p12 chr 11 NC_000011.10:g.73983709= NC_000011.10:g.73983709C>T
GRCh37.p13 chr 11 NC_000011.9:g.73694754= NC_000011.9:g.73694754C>T
UCP2 RefSeqGene NG_011478.1:g.4136= NG_011478.1:g.4136G>A
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

117 SubSNP, 9 Frequency, 1 ClinVar submissions
No Submitter Submission ID Date (Build)
1 SC_JCM ss832508 Aug 11, 2000 (83)
2 KWOK ss1117334 Oct 04, 2000 (86)
3 KWOK ss1999769 Oct 18, 2000 (87)
4 TSC-CSHL ss2178839 Oct 23, 2000 (88)
5 YUSUKE ss5016438 Aug 28, 2002 (108)
6 TSC-CSHL ss5500464 Oct 08, 2002 (108)
7 SC_SNP ss16163393 Feb 27, 2004 (120)
8 KYUGEN ss28461448 Sep 20, 2004 (123)
9 ABI ss38739472 Mar 14, 2006 (126)
10 ILLUMINA ss66720703 Dec 01, 2006 (127)
11 ILLUMINA ss67477259 Dec 01, 2006 (127)
12 ILLUMINA ss67833473 Dec 01, 2006 (127)
13 EGP_SNPS ss70454411 May 17, 2007 (127)
14 ILLUMINA ss70875799 May 25, 2008 (130)
15 ILLUMINA ss71465496 May 17, 2007 (127)
16 AFFY ss74822427 Aug 16, 2007 (128)
17 ILLUMINA ss75626588 Dec 06, 2007 (129)
18 AFFY ss76787247 Dec 06, 2007 (129)
19 ILLUMINA ss79227513 Dec 15, 2007 (130)
20 HGSV ss80705557 Dec 15, 2007 (130)
21 KRIBB_YJKIM ss83510274 Dec 15, 2007 (130)
22 BGI ss106751979 Feb 05, 2009 (130)
23 1000GENOMES ss110656470 Jan 25, 2009 (130)
24 1000GENOMES ss114786745 Jan 25, 2009 (130)
25 ILLUMINA-UK ss119893435 Dec 01, 2009 (131)
26 ILLUMINA ss122580441 Dec 01, 2009 (131)
27 ILLUMINA ss154371161 Dec 01, 2009 (131)
28 ILLUMINA ss159547256 Dec 01, 2009 (131)
29 ILLUMINA ss160790809 Dec 01, 2009 (131)
30 COMPLETE_GENOMICS ss168565678 Jul 04, 2010 (132)
31 COMPLETE_GENOMICS ss170240984 Jul 04, 2010 (132)
32 ILLUMINA ss172158981 Jul 04, 2010 (132)
33 ILLUMINA ss174044668 Jul 04, 2010 (132)
34 COMPLETE_GENOMICS ss175184841 Jul 04, 2010 (132)
35 BUSHMAN ss202877943 Jul 04, 2010 (132)
36 1000GENOMES ss225313137 Jul 14, 2010 (132)
37 1000GENOMES ss235611261 Jul 15, 2010 (132)
38 1000GENOMES ss242233314 Jul 15, 2010 (132)
39 ILLUMINA ss244305607 Jul 04, 2010 (132)
40 BL ss255277032 May 09, 2011 (134)
41 GMI ss281065215 May 04, 2012 (137)
42 PJP ss291072577 May 09, 2011 (134)
43 ILLUMINA ss481295381 May 04, 2012 (137)
44 ILLUMINA ss481320214 May 04, 2012 (137)
45 ILLUMINA ss482302516 Sep 08, 2015 (146)
46 ILLUMINA ss485442954 May 04, 2012 (137)
47 ILLUMINA ss537369317 Sep 08, 2015 (146)
48 TISHKOFF ss562650232 Apr 25, 2013 (138)
49 SSMP ss658165991 Apr 25, 2013 (138)
50 ILLUMINA ss778945495 Sep 08, 2015 (146)
51 ILLUMINA ss783166931 Sep 08, 2015 (146)
52 ILLUMINA ss784122575 Sep 08, 2015 (146)
53 ILLUMINA ss825558031 Apr 01, 2015 (144)
54 ILLUMINA ss832426400 Sep 08, 2015 (146)
55 ILLUMINA ss833058445 Jul 13, 2019 (153)
56 ILLUMINA ss834407263 Sep 08, 2015 (146)
57 EVA-GONL ss988674514 Aug 21, 2014 (142)
58 JMKIDD_LAB ss1077832596 Aug 21, 2014 (142)
59 1000GENOMES ss1341880898 Aug 21, 2014 (142)
60 DDI ss1426675517 Apr 01, 2015 (144)
61 OMIM-CURATED-RECORDS ss1505811007 Dec 08, 2014 (142)
62 EVA_GENOME_DK ss1575793090 Apr 01, 2015 (144)
63 EVA_DECODE ss1598335703 Apr 01, 2015 (144)
64 EVA_UK10K_ALSPAC ss1626893027 Apr 01, 2015 (144)
65 EVA_UK10K_TWINSUK ss1669887060 Apr 01, 2015 (144)
66 EVA_SVP ss1713264080 Apr 01, 2015 (144)
67 ILLUMINA ss1752031577 Sep 08, 2015 (146)
68 HAMMER_LAB ss1806876124 Sep 08, 2015 (146)
69 WEILL_CORNELL_DGM ss1932032256 Feb 12, 2016 (147)
70 ILLUMINA ss1946316041 Feb 12, 2016 (147)
71 ILLUMINA ss1959365055 Feb 12, 2016 (147)
72 GENOMED ss1967391131 Jul 19, 2016 (147)
73 JJLAB ss2026760289 Sep 14, 2016 (149)
74 USC_VALOUEV ss2155071007 Dec 20, 2016 (150)
75 HUMAN_LONGEVITY ss2183533027 Dec 20, 2016 (150)
76 TOPMED ss2347019310 Dec 20, 2016 (150)
77 SYSTEMSBIOZJU ss2627853837 Nov 08, 2017 (151)
78 ILLUMINA ss2632850691 Nov 08, 2017 (151)
79 GRF ss2699365846 Nov 08, 2017 (151)
80 ILLUMINA ss2710739404 Nov 08, 2017 (151)
81 GNOMAD ss2901398630 Nov 08, 2017 (151)
82 AFFY ss2984949884 Nov 08, 2017 (151)
83 AFFY ss2985592069 Nov 08, 2017 (151)
84 SWEGEN ss3008345040 Nov 08, 2017 (151)
85 ILLUMINA ss3021352839 Nov 08, 2017 (151)
86 BIOINF_KMB_FNS_UNIBA ss3027177362 Nov 08, 2017 (151)
87 TOPMED ss3149359988 Nov 08, 2017 (151)
88 CSHL ss3349667099 Nov 08, 2017 (151)
89 ILLUMINA ss3625604121 Oct 12, 2018 (152)
90 ILLUMINA ss3626689941 Oct 12, 2018 (152)
91 ILLUMINA ss3630866741 Oct 12, 2018 (152)
92 ILLUMINA ss3632990057 Oct 12, 2018 (152)
93 ILLUMINA ss3633689634 Oct 12, 2018 (152)
94 ILLUMINA ss3634463073 Oct 12, 2018 (152)
95 ILLUMINA ss3635381148 Oct 12, 2018 (152)
96 ILLUMINA ss3636146280 Oct 12, 2018 (152)
97 ILLUMINA ss3637132020 Oct 12, 2018 (152)
98 ILLUMINA ss3637915485 Oct 12, 2018 (152)
99 ILLUMINA ss3638971337 Oct 12, 2018 (152)
100 ILLUMINA ss3639486627 Oct 12, 2018 (152)
101 ILLUMINA ss3640170412 Oct 12, 2018 (152)
102 ILLUMINA ss3641017334 Oct 12, 2018 (152)
103 ILLUMINA ss3641311804 Oct 12, 2018 (152)
104 ILLUMINA ss3642913157 Oct 12, 2018 (152)
105 ILLUMINA ss3644568858 Oct 12, 2018 (152)
106 ILLUMINA ss3651718349 Oct 12, 2018 (152)
107 ILLUMINA ss3653721945 Oct 12, 2018 (152)
108 EGCUT_WGS ss3675664150 Jul 13, 2019 (153)
109 EVA_DECODE ss3692080856 Jul 13, 2019 (153)
110 ILLUMINA ss3725255245 Jul 13, 2019 (153)
111 ACPOP ss3738304533 Jul 13, 2019 (153)
112 ILLUMINA ss3744086802 Jul 13, 2019 (153)
113 ILLUMINA ss3744763894 Jul 13, 2019 (153)
114 EVA ss3749480718 Jul 13, 2019 (153)
115 PAGE_CC ss3771635899 Jul 13, 2019 (153)
116 ILLUMINA ss3772263752 Jul 13, 2019 (153)
117 KHV_HUMAN_GENOMES ss3814816677 Jul 13, 2019 (153)
118 1000Genomes NC_000011.9 - 73694754 Oct 12, 2018 (152)
119 The Avon Longitudinal Study of Parents and Children NC_000011.9 - 73694754 Oct 12, 2018 (152)
120 Genetic variation in the Estonian population NC_000011.9 - 73694754 Oct 12, 2018 (152)
121 gnomAD - Genomes NC_000011.9 - 73694754 Jul 13, 2019 (153)
122 Northern Sweden NC_000011.9 - 73694754 Jul 13, 2019 (153)
123 The PAGE Study NC_000011.10 - 73983709 Jul 13, 2019 (153)
124 TopMed NC_000011.10 - 73983709 Oct 12, 2018 (152)
125 UK 10K study - Twins NC_000011.9 - 73694754 Oct 12, 2018 (152)
126 A Vietnamese Genetic Variation Database NC_000011.9 - 73694754 Jul 13, 2019 (153)
127 ClinVar RCV000023142.3 Oct 12, 2018 (152)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs3829934 Oct 08, 2002 (108)
rs17174147 Oct 08, 2004 (123)
rs52801495 Sep 21, 2007 (128)
rs59575906 May 25, 2008 (130)
Added to this RefSNP Cluster:
Submission ids Observation SPDI Canonical SPDI Source RSIDs
ss76787247, ss80705557, ss110656470, ss114786745, ss119893435, ss168565678, ss170240984, ss175184841, ss202877943, ss255277032, ss281065215, ss291072577, ss481295381, ss825558031, ss1598335703, ss1713264080, ss3638971337, ss3639486627, ss3642913157 NC_000011.8:73372401:C:T NC_000011.10:73983708:C:T (self)
54423633, 30207601, 21402398, 148635478, 11589398, 30207601, 6701515, ss225313137, ss235611261, ss242233314, ss481320214, ss482302516, ss485442954, ss537369317, ss562650232, ss658165991, ss778945495, ss783166931, ss784122575, ss832426400, ss833058445, ss834407263, ss988674514, ss1077832596, ss1341880898, ss1426675517, ss1575793090, ss1626893027, ss1669887060, ss1752031577, ss1806876124, ss1932032256, ss1946316041, ss1959365055, ss1967391131, ss2026760289, ss2155071007, ss2347019310, ss2627853837, ss2632850691, ss2699365846, ss2710739404, ss2901398630, ss2984949884, ss2985592069, ss3008345040, ss3021352839, ss3349667099, ss3625604121, ss3626689941, ss3630866741, ss3632990057, ss3633689634, ss3634463073, ss3635381148, ss3636146280, ss3637132020, ss3637915485, ss3640170412, ss3641017334, ss3641311804, ss3644568858, ss3651718349, ss3653721945, ss3675664150, ss3738304533, ss3744086802, ss3744763894, ss3749480718, ss3772263752 NC_000011.9:73694753:C:T NC_000011.10:73983708:C:T (self)
RCV000023142.3, 857368, 66553809, ss1505811007, ss2183533027, ss3027177362, ss3149359988, ss3692080856, ss3725255245, ss3771635899, ss3814816677 NC_000011.10:73983708:C:T NC_000011.10:73983708:C:T (self)
ss16163393 NT_033927.6:3893782:C:T NC_000011.10:73983708:C:T (self)
ss832508, ss1117334, ss1999769, ss2178839, ss5016438, ss5500464, ss28461448, ss38739472, ss66720703, ss67477259, ss67833473, ss70454411, ss70875799, ss71465496, ss74822427, ss75626588, ss79227513, ss83510274, ss106751979, ss122580441, ss154371161, ss159547256, ss160790809, ss172158981, ss174044668, ss244305607 NT_167190.1:19000548:C:T NC_000011.10:73983708:C:T (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

50 citations for rs659366
PMID Title Author Year Journal
11381268 A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Esterbauer H et al. 2001 Nature genetics
15562023 The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy. Bulotta A et al. 2005 The Journal of clinical endocrinology and metabolism
16046815 Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes. Wren JD et al. 2005 Journal of biomedicine & biotechnology
17570749 Genetic prediction of future type 2 diabetes. Lyssenko V et al. 2005 PLoS medicine
17701054 Interaction between the UCP2-866G/A, mtDNA 10398G/A and PGC1alpha p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population. Rai E et al. 2007 Human genetics
17870627 Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents. Ochoa MC et al. 2007 Molecular genetics and metabolism
19387457 Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases. Yu X et al. 2009 Genes and immunity
19406964 Association of genetic variants with chronic kidney disease in Japanese individuals. Yoshida T et al. 2009 Clinical journal of the American Society of Nephrology
19681913 Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus. Crispim D et al. 2010 Clinical endocrinology
19769793 Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study. Salopuro T et al. 2009 BMC medical genetics
19876010 A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. Papathanasopoulos A et al. 2010 Obesity (Silver Spring, Md.)
20145583 Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes. Beitelshees AL et al. 2010 Pharmacogenetics and genomics
20359253 Effect of the common -866G/A polymorphism of the uncoupling protein 2 gene on weight loss and body composition under sibutramine therapy in an obese Taiwanese population. Hsiao TJ et al. 2010 Molecular diagnosis & therapy
21074158 Mitochondrial uncoupling protein gene cluster variation (UCP2-UCP3) and the risk of incident type 2 diabetes mellitus: the Women's Genome Health Study. Zee RY et al. 2011 Atherosclerosis
21204206 Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population. Carter TC et al. 2011 American journal of medical genetics. Part A
21603268 Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366). Dalgaard LT et al. 2011 Journal of obesity
21883184 Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population. Martinez-Hervas S et al. 2012 European journal of clinical investigation
22216339 Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity. Rose G et al. 2011 PloS one
22241057 Variation in the uncoupling protein 2 and 3 genes and human performance. Dhamrait SS et al. 2012 Journal of applied physiology (Bethesda, Md.
22291493 A common variant in the adiponectin gene on weight loss and body composition under sibutramine therapy in obesity. Hsiao TJ et al. 2010 Clinical pharmacology
22349573 The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17‚ÄČ636 Danes. Andersen G et al. 2013 International journal of obesity (2005)
22533685 Uncoupling protein 2 gene polymorphisms are associated with obesity. Oktavianthi S et al. 2012 Cardiovascular diabetology
23133645 The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population. Rai E et al. 2012 PloS one
23639961 Uncoupling protein 2 -866G/A and uncoupling protein 3 -55C/T polymorphisms in young South African Indian coronary artery disease patients. Phulukdaree A et al. 2013 Gene
24804925 Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability. Brondani LA et al. 2014 PloS one
24879436 Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries. Tan LJ et al. 2014 PloS one
25368670 CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits. Parnell LD et al. 2014 BioData mining
25396419 Investigation of variants in UCP2 in Chinese type 2 diabetes and diabetic retinopathy. Shen Y et al. 2014 PloS one
25755013 Association of UCP-3 rs1626521 with obesity and stomach functions in humans. Acosta A et al. 2015 Obesity (Silver Spring, Md.)
26526553 Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study. Vimaleswaran KS et al. 2015 European journal of endocrinology
26648684 Update on genetics and diabetic retinopathy. Hampton BM et al. 2015 Clinical ophthalmology (Auckland, N.Z.)
26765095 Genetic variants within telomere-associated genes, leukocyte telomere length and the risk of acute coronary syndrome in Czech women. Dlouha D et al. 2016 Clinica chimica acta; international journal of clinical chemistry
26870959 Association of PON1, P2Y12 and COX1 with Recurrent Ischemic Events in Patients with Extracranial or Intracranial Stenting. Li XQ et al. 2016 PloS one
26951191 Shortened leukocyte telomere length in type 2 diabetes mellitus: genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways. Zhou Y et al. 2016 Clinical and translational medicine
27159875 Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus. Kautzky-Willer A et al. 2016 Endocrine reviews
27301474 Major components of metabolic syndrome and nutritional intakes in different genotype of UCP2 -866G/A gene polymorphisms in patients with NAFLD. Abbasalizad Farhangi M et al. 2016 Journal of translational medicine
27615599 Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes. Zhou Y et al. 2016 Scientific reports
27794526 Association of UCP2 -866G>A Polymorphism With Nonalcoholic Fatty Liver Disease in Patients From North-West of Iran. Mohseni F et al. 2017 Laboratory medicine
27806373 The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass. Nicoletti CF et al. 2016 Journal of nutrigenetics and nutrigenomics
28281015 Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis. Dato S et al. 2017 Biogerontology
28636007 Analysis of association of gene variants with obesity traits in New Zealand European children at 6 years of age. Krishnan M et al. 2017 Molecular bioSystems
28771482 Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults. Heise V et al. 2017 PloS one
28977211 Association of 5-HT2C (rs3813929) and UCP3 (rs1800849) gene polymorphisms with type 2 diabetes in obese women candidates for bariatric surgery. Schnor NPP et al. 2017 Archives of endocrinology and metabolism
29786102 The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population. Gamboa R et al. 2018 Genetics and molecular biology
30226308 [Association of <i>UCP2</i> rs659366 polymorphisms with the outcomes of patients after surgery for colorectal cancer]. Jiang Y et al. 2018 Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
30359091 Polymorphisms in the Uncoupling Protein 2 Gene Are Associated with Diabetic Retinopathy in Han Chinese Patients with Type 2 Diabetes. Zhou TC et al. 2018 Genetic testing and molecular biomarkers
30393491 Association of common polymorphisms in the <i>VEGFA</i> and <i>SIRT1</i> genes with type 2 diabetes-related traits in Mexicans. Totomoch-Serra A et al. 2018 Archives of medical science
30444569 Genetic determinants of steatosis and fibrosis progression in paediatric non-alcoholic fatty liver disease. Hudert CA et al. 2019 Liver international
30518806 Association of uncoupling protein gene polymorphisms with essential hypertension in a northeastern Han Chinese population. Sun H et al. 2019 Journal of human hypertension
30645860 [The association of <i>rs993609</i> polymorphisms of gene <i>FTO</i> and <i>rs659366</i> polymorphisms of gene <i>UCP2</i> with obesity among Arctic Russian population]. Baturin AK et al. 2017 Voprosy pitaniia

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post104+4a6ee9c