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dbSNP Short Genetic Variations

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs651821

Current Build 152

Released October 2, 2018

Organism
Homo sapiens
Position
chr11:116791863 (GRCh38.p12) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
C>T
Variation Type
SNV Single Nucleotide Variation
Frequency
C=0.12055 (29601/245548, GnomAD)
C=0.11498 (14438/125568, TOPMED)
C=0.12011 (14481/120560, ExAC) (+ 6 more)
C=0.1083 (3349/30924, GnomAD)
C=0.0945 (1228/12994, GO-ESP)
C=0.176 (879/5008, 1000G)
C=0.072 (323/4480, Estonian)
C=0.062 (239/3854, ALSPAC)
C=0.058 (216/3708, TWINSUK)
Clinical Significance
Not Reported in ClinVar
Gene : Consequence
APOA5 : 5 Prime UTR Variant
Publications
40 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p12 chr 11 NC_000011.10:g.116791863C>T
GRCh37.p13 chr 11 NC_000011.9:g.116662579C>T
APOA5 RefSeqGene NG_015894.1:g.5558A>G
LOC108491825 genomic region NG_051344.1:g.918C>T
Gene: APOA5, apolipoprotein A5 (minus strand)
Molecule type Change Amino acid[Codon] SO Term
APOA5 transcript variant 2 NM_001166598.1:c. N/A 5 Prime UTR Variant
APOA5 transcript variant 1 NM_052968.4:c. N/A 5 Prime UTR Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar
Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study Population Group Sample Size Ref Allele Alt Allele
gnomAD - Exomes Global Study-wide 245548 C=0.12055 T=0.87945
gnomAD - Exomes European Sub 133534 C=0.06899 T=0.93101
gnomAD - Exomes Asian Sub 47962 C=0.2196 T=0.7804
gnomAD - Exomes American Sub 33502 C=0.1789 T=0.8211
gnomAD - Exomes African Sub 15232 C=0.1513 T=0.8487
gnomAD - Exomes Ashkenazi Jewish Sub 9842 C=0.099 T=0.901
gnomAD - Exomes Other Sub 5476 C=0.107 T=0.893
TopMed Global Study-wide 125568 C=0.11498 T=0.88502
ExAC Global Study-wide 120560 C=0.12011 T=0.87989
ExAC Europe Sub 72796 C=0.0718 T=0.9282
ExAC Asian Sub 25066 C=0.2192 T=0.7808
ExAC American Sub 11478 C=0.1820 T=0.8180
ExAC African Sub 10320 C=0.1522 T=0.8478
ExAC Other Sub 900 C=0.11 T=0.89
gnomAD - Genomes Global Study-wide 30924 C=0.1083 T=0.8917
gnomAD - Genomes European Sub 18470 C=0.0710 T=0.9290
gnomAD - Genomes African Sub 8714 C=0.149 T=0.851
gnomAD - Genomes East Asian Sub 1618 C=0.290 T=0.710
gnomAD - Genomes Other Sub 982 C=0.10 T=0.90
gnomAD - Genomes American Sub 838 C=0.15 T=0.85
gnomAD - Genomes Ashkenazi Jewish Sub 302 C=0.14 T=0.86
GO Exome Sequencing Project Global Study-wide 12994 C=0.0945 T=0.9055
GO Exome Sequencing Project European American Sub 8592 C=0.069 T=0.931
GO Exome Sequencing Project African American Sub 4402 C=0.145 T=0.855
1000Genomes Global Study-wide 5008 C=0.176 T=0.824
1000Genomes African Sub 1322 C=0.160 T=0.840
1000Genomes East Asian Sub 1008 C=0.288 T=0.712
1000Genomes Europe Sub 1006 C=0.083 T=0.917
1000Genomes South Asian Sub 978 C=0.19 T=0.81
1000Genomes American Sub 694 C=0.15 T=0.85
Genetic variation in the Estonian population Estonian Study-wide 4480 C=0.072 T=0.928
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 C=0.062 T=0.938
UK 10K study - Twins TWIN COHORT Study-wide 3708 C=0.058 T=0.942
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Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement C= T Note
GRCh38.p12 chr 11 NC_000011.10:g.116791863C= NC_000011.10:g.11679186...

NC_000011.10:g.116791863C>T

GRCh37.p13 chr 11 NC_000011.9:g.116662579C= NC_000011.9:g.116662579C>T
APOA5 RefSeqGene NG_015894.1:g.5558A>G NG_015894.1:g.5558A=
APOA5 transcript variant 1 NM_052968.4:c.-3A>G NM_052968.4:c.-3A=
APOA5 transcript variant 2 NM_001166598.1:c.-3A>G NM_001166598.1:c.-3A=
LOC108491825 genomic region NG_051344.1:g.918C= NG_051344.1:g.918C>T
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

116 SubSNP, 9 Frequency submissions
No Submitter Submission ID Date (Build)
1 SC_JCM ss824800 Aug 11, 2000 (83)
2 KWOK ss1943493 Oct 18, 2000 (87)
3 KWOK ss1944008 Oct 18, 2000 (87)
4 YUSUKE ss3197114 Aug 15, 2001 (98)
5 BERKELEYPGA ss4383596 Mar 26, 2002 (103)
6 CSHL-HAPMAP ss17435550 Feb 27, 2004 (120)
7 SSAHASNP ss20817165 Apr 05, 2004 (121)
8 ILLUMINA ss65731823 Oct 16, 2006 (127)
9 SHGC ss66536760 Dec 01, 2006 (127)
10 RSG_JCVI ss69359425 May 17, 2007 (127)
11 PHARMGKB_PARC ss69364818 May 17, 2007 (127)
12 ILLUMINA ss74899151 Dec 07, 2007 (129)
13 AFFY ss76849956 Dec 07, 2007 (129)
14 HGSV ss77325802 Dec 07, 2007 (129)
15 HGSV ss78836086 Dec 07, 2007 (129)
16 HGSV ss82621175 Dec 15, 2007 (130)
17 HGSV ss84890564 Dec 15, 2007 (130)
18 HGSV ss85040044 Dec 15, 2007 (130)
19 BCMHGSC_JDW ss88817263 Mar 24, 2008 (129)
20 SHGC ss95216912 Feb 06, 2009 (130)
21 HUMANGENOME_JCVI ss97420659 Feb 06, 2009 (130)
22 KRIBB_YJKIM ss104797570 Feb 06, 2009 (130)
23 BGI ss106773132 Feb 06, 2009 (130)
24 1000GENOMES ss111136805 Jan 25, 2009 (130)
25 1000GENOMES ss115232511 Jan 25, 2009 (130)
26 KRIBB_YJKIM ss119361538 Dec 01, 2009 (131)
27 ILLUMINA-UK ss119965527 Dec 01, 2009 (131)
28 ENSEMBL ss132856999 Dec 01, 2009 (131)
29 ENSEMBL ss137843962 Dec 01, 2009 (131)
30 GMI ss156838150 Dec 01, 2009 (131)
31 ILLUMINA ss160782729 Dec 01, 2009 (131)
32 COMPLETE_GENOMICS ss168765747 Jul 04, 2010 (132)
33 COMPLETE_GENOMICS ss170961908 Jul 04, 2010 (132)
34 ILLUMINA ss174023928 Jul 04, 2010 (132)
35 COMPLETE_GENOMICS ss175289987 Jul 04, 2010 (132)
36 BUSHMAN ss203259712 Jul 04, 2010 (132)
37 BCM-HGSC-SUB ss207575592 Jul 04, 2010 (132)
38 1000GENOMES ss225483265 Jul 14, 2010 (132)
39 1000GENOMES ss235734787 Jul 15, 2010 (132)
40 1000GENOMES ss242329689 Jul 15, 2010 (132)
41 ILLUMINA ss244305256 Jul 04, 2010 (132)
42 BL ss255392773 May 09, 2011 (134)
43 GMI ss281185478 May 04, 2012 (137)
44 GMI ss286464867 Apr 25, 2013 (138)
45 PJP ss291147855 May 09, 2011 (134)
46 ILLUMINA ss410941565 Sep 17, 2011 (135)
47 ILLUMINA ss481269925 May 04, 2012 (137)
48 ILLUMINA ss481294341 May 04, 2012 (137)
49 ILLUMINA ss482278033 Sep 08, 2015 (146)
50 ILLUMINA ss485430236 May 04, 2012 (137)
51 1000GENOMES ss491029782 May 04, 2012 (137)
52 CLINSEQ_SNP ss491654455 May 04, 2012 (137)
53 ILLUMINA ss534118125 Sep 08, 2015 (146)
54 TISHKOFF ss562850008 Apr 25, 2013 (138)
55 SSMP ss658374057 Apr 25, 2013 (138)
56 NHLBI-ESP ss713058501 Apr 25, 2013 (138)
57 ILLUMINA ss779045897 Aug 21, 2014 (142)
58 ILLUMINA ss783160562 Sep 08, 2015 (146)
59 ILLUMINA ss784116337 Aug 21, 2014 (142)
60 ILLUMINA ss832419925 Sep 08, 2015 (146)
61 ILLUMINA ss834508803 Aug 21, 2014 (142)
62 JMKIDD_LAB ss974481242 Aug 21, 2014 (142)
63 EVA-GONL ss989003453 Aug 21, 2014 (142)
64 JMKIDD_LAB ss1067528375 Aug 21, 2014 (142)
65 JMKIDD_LAB ss1078075923 Aug 21, 2014 (142)
66 1000GENOMES ss1343123059 Aug 21, 2014 (142)
67 DDI ss1426773668 Apr 01, 2015 (144)
68 EVA_GENOME_DK ss1575976367 Apr 01, 2015 (144)
69 EVA_FINRISK ss1584078171 Apr 01, 2015 (144)
70 EVA_DECODE ss1598670278 Apr 01, 2015 (144)
71 EVA_UK10K_ALSPAC ss1627548718 Apr 01, 2015 (144)
72 EVA_UK10K_TWINSUK ss1670542751 Apr 01, 2015 (144)
73 EVA_EXAC ss1690644450 Apr 01, 2015 (144)
74 EVA_MGP ss1711309717 Apr 01, 2015 (144)
75 EVA_SVP ss1713288068 Apr 01, 2015 (144)
76 ILLUMINA ss1751996770 Sep 08, 2015 (146)
77 HAMMER_LAB ss1807013969 Sep 08, 2015 (146)
78 WEILL_CORNELL_DGM ss1932365531 Feb 12, 2016 (147)
79 ILLUMINA ss1946323727 Feb 12, 2016 (147)
80 ILLUMINA ss1959389241 Feb 12, 2016 (147)
81 GENOMED ss1967468706 Jul 19, 2016 (147)
82 JJLAB ss2026926559 Sep 14, 2016 (149)
83 ILLUMINA ss2094792054 Dec 20, 2016 (150)
84 ILLUMINA ss2095027115 Dec 20, 2016 (150)
85 USC_VALOUEV ss2155240040 Dec 20, 2016 (150)
86 HUMAN_LONGEVITY ss2186032675 Dec 20, 2016 (150)
87 TOPMED ss2349625024 Dec 20, 2016 (150)
88 SYSTEMSBIOZJU ss2627937971 Nov 08, 2017 (151)
89 ILLUMINA ss2632892649 Nov 08, 2017 (151)
90 GRF ss2699550821 Nov 08, 2017 (151)
91 ILLUMINA ss2710747141 Nov 08, 2017 (151)
92 GNOMAD ss2739406718 Nov 08, 2017 (151)
93 GNOMAD ss2748745118 Nov 08, 2017 (151)
94 GNOMAD ss2904898315 Nov 08, 2017 (151)
95 AFFY ss2985600247 Nov 08, 2017 (151)
96 SWEGEN ss3008842926 Nov 08, 2017 (151)
97 ILLUMINA ss3021380075 Nov 08, 2017 (151)
98 BIOINF_KMB_FNS_UNIBA ss3027264437 Nov 08, 2017 (151)
99 TOPMED ss3157407145 Nov 08, 2017 (151)
100 CSHL ss3349813324 Nov 08, 2017 (151)
101 ILLUMINA ss3625610305 Oct 12, 2018 (152)
102 ILLUMINA ss3626759078 Oct 12, 2018 (152)
103 ILLUMINA ss3630906277 Oct 12, 2018 (152)
104 ILLUMINA ss3633000956 Oct 12, 2018 (152)
105 ILLUMINA ss3633700967 Oct 12, 2018 (152)
106 ILLUMINA ss3634477354 Oct 12, 2018 (152)
107 ILLUMINA ss3635392220 Oct 12, 2018 (152)
108 ILLUMINA ss3636161709 Oct 12, 2018 (152)
109 ILLUMINA ss3637143128 Oct 12, 2018 (152)
110 ILLUMINA ss3637932740 Oct 12, 2018 (152)
111 ILLUMINA ss3640184690 Oct 12, 2018 (152)
112 ILLUMINA ss3642929025 Oct 12, 2018 (152)
113 ILLUMINA ss3644576587 Oct 12, 2018 (152)
114 OMUKHERJEE_ADBS ss3646433064 Oct 12, 2018 (152)
115 URBANLAB ss3649713576 Oct 12, 2018 (152)
116 ILLUMINA ss3651748405 Oct 12, 2018 (152)
117 1000Genomes NC_000011.9 - 116662579 Oct 12, 2018 (152)
118 The Avon Longitudinal Study of Parents and Children NC_000011.9 - 116662579 Oct 12, 2018 (152)
119 Genetic variation in the Estonian population NC_000011.9 - 116662579 Oct 12, 2018 (152)
120 ExAC NC_000011.9 - 116662579 Oct 12, 2018 (152)
121 gnomAD - Genomes NC_000011.9 - 116662579 Oct 12, 2018 (152)
122 gnomAD - Exomes NC_000011.9 - 116662579 Oct 12, 2018 (152)
123 GO Exome Sequencing Project NC_000011.9 - 116662579 Oct 12, 2018 (152)
124 TopMed NC_000011.10 - 116791863 Oct 12, 2018 (152)
125 UK 10K study - Twins NC_000011.9 - 116662579 Oct 12, 2018 (152)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs60962092 May 26, 2008 (130)
Added to this RefSNP Cluster:
Submission ids Observation SPDI Canonical SPDI Source RSIDs
ss76849956, ss77325802, ss78836086, ss82621175, ss84890564, ss85040044, ss88817263, ss111136805, ss115232511, ss119965527, ss168765747, ss170961908, ss175289987, ss203259712, ss207575592, ss255392773, ss281185478, ss286464867, ss291147855, ss481269925, ss491654455, ss1598670278, ss1713288068, ss3642929025 NC_000011.8:116167788:C:T NC_000011.10:116791862:C:T (self)
55710763, 30926317, 21909312, 921403, 38599837, 6822911, 1131403, 30926317, ss225483265, ss235734787, ss242329689, ss481294341, ss482278033, ss485430236, ss491029782, ss534118125, ss562850008, ss658374057, ss713058501, ss779045897, ss783160562, ss784116337, ss832419925, ss834508803, ss974481242, ss989003453, ss1067528375, ss1078075923, ss1343123059, ss1426773668, ss1575976367, ss1584078171, ss1627548718, ss1670542751, ss1690644450, ss1711309717, ss1751996770, ss1807013969, ss1932365531, ss1946323727, ss1959389241, ss1967468706, ss2026926559, ss2094792054, ss2095027115, ss2155240040, ss2349625024, ss2627937971, ss2632892649, ss2699550821, ss2710747141, ss2739406718, ss2748745118, ss2904898315, ss2985600247, ss3008842926, ss3021380075, ss3349813324, ss3625610305, ss3626759078, ss3630906277, ss3633000956, ss3633700967, ss3634477354, ss3635392220, ss3636161709, ss3637143128, ss3637932740, ss3640184690, ss3644576587, ss3646433064, ss3651748405 NC_000011.9:116662578:C:T NC_000011.10:116791862:C:T (self)
73273961, ss2186032675, ss3027264437, ss3157407145, ss3649713576 NC_000011.10:116791862:C:T NC_000011.10:116791862:C:T (self)
ss17435550, ss20817165 NT_033899.6:20206365:C:T NC_000011.10:116791862:C:T (self)
ss824800, ss1943493, ss1944008, ss3197114, ss4383596, ss65731823, ss66536760, ss69359425, ss69364818, ss74899151, ss95216912, ss97420659, ss104797570, ss106773132, ss119361538, ss132856999, ss137843962, ss156838150, ss160782729, ss174023928, ss244305256, ss410941565 NT_033899.8:20224994:C:T NC_000011.10:116791862:C:T (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

40 citations for rs651821
PMID Title Author Year Journal
17357073 Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. Pare G et al. 2007 American journal of human genetics
17357083 Medical sequencing at the extremes of human body mass. Ahituv N et al. 2007 American journal of human genetics
18078817 Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics. Liao YC et al. 2008 Clinical biochemistry
18196181 Correction of population stratification in large multi-ethnic association studies. Serre D et al. 2008 PloS one
18441017 An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients. Pullinger CR et al. 2008 Journal of lipid research
19041386 Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review. Boes E et al. 2009 Experimental gerontology
19299407 Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample. Lanktree MB et al. 2009 Journal of lipid research
19732897 Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese. Liu ZK et al. 2010 Atherosclerosis
19913121 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ et al. 2009 American journal of human genetics
20054229 Gene-gene interaction between APOA5 and USF1: two candidate genes for the metabolic syndrome. Singmann P et al. 2009 Obesity facts
20335584 Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. Petersen KF et al. 2010 The New England journal of medicine
20395964 Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins. Ken-Dror G et al. 2010 Journal of human genetics
20452521 Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration. et al. 2010 Lancet (London, England)
20570915 Genetic determinants of major blood lipids in Pakistanis compared with Europeans. Saleheen D et al. 2010 Circulation. Cardiovascular genetics
21375366 Impact of apolipoprotein A5 (APOA5) polymorphisms on serum triglyceride levels in schizophrenic patients under long-term atypical antipsychotic treatment. Hong CJ et al. 2012 The world journal of biological psychiatry
21527746 Triglycerides and heart disease: still a hypothesis? Goldberg IJ et al. 2011 Arteriosclerosis, thrombosis, and vascular biology
21860704 Implications of discoveries from genome-wide association studies in current cardiovascular practice. Jeemon P et al. 2011 World journal of cardiology
21880794 Type 1 hyperlipoproteinemia and recurrent acute pancreatitis due to lipoprotein lipase antibody in a young girl with Sjogren's syndrome. Ashraf AP et al. 2011 The Journal of clinical endocrinology and metabolism
21889769 Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia. Brautbar A et al. 2011 Atherosclerosis
22171074 A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. Tan A et al. 2012 Human molecular genetics
22425169 Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol. Shirts BH et al. 2012 Atherosclerosis
22460246 Influence of genetic variants in the apolipoprotein A5 and C3 gene on lipids, lipoproteins, and its association with coronary artery disease in Indians. Bhanushali AA et al. 2010 Journal of community genetics
23497168 Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population. Rudkowska I et al. 2013 Nutrition & metabolism
24178511 Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip. Gaunt TR et al. 2013 Thrombosis and haemostasis
24725463 Analysis of common and coding variants with cardiovascular disease in the Diabetes Heart Study. Adams JN et al. 2014 Cardiovascular diabetology
24903888 Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents. Zhu WF et al. 2014 Lipids in health and disease
24918908 Genomic and metabolomic profile associated to microalbuminuria. Marrachelli VG et al. 2014 PloS one
26345861 Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia. Ou HJ et al. 2015 Genetics and molecular research
26397108 Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population. Fu Q et al. 2015 PloS one
26634697 Multiple susceptibility loci at chromosome 11q23.3 are associated with plasma triglyceride in East Asians. Gombojav B et al. 2016 Journal of lipid research
26690388 Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese. Tang CS et al. 2015 Nature communications
26824674 Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome. Wu Y et al. 2016 PloS one
27257688 Distinct Patterns of Association of Variants at 11q23.3 Chromosomal Region with Coronary Artery Disease and Dyslipidemia in the Population of Andhra Pradesh, India. Pranav Chand R et al. 2016 PloS one
28067407 Analysis of Whole Exome Sequencing with Cardiometabolic Traits Using Family-Based Linkage and Association in the IRAS Family Study. Tabb KL et al. 2017 Annals of human genetics
28099408 Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202. Verma A et al. 2017 Pharmacogenetics and genomics
28371326 Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study. Zhu Y et al. 2017 Journal of cellular and molecular medicine
28624160 Association of apolipoprotein A5 gene variants with metabolic syndrome in Tunisian population. Kefi R et al. 2017 Annales d'endocrinologie
28947988 Association analysis of <i>APO</i> gene polymorphisms with ischemic stroke risk: a case-control study in a Chinese Han population. Xiao R et al. 2017 Oncotarget
29618726 Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS). Gao C et al. 2018 Scientific reports
29866721 Effects of polymorphisms in APOA5 on the plasma levels of triglycerides and risk of coronary heart disease in Jilin, northeast China: a case-control study. You Y et al. 2018 BMJ open

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post104+4a6ee9c