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dbSNP Short Genetic Variations

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs6265

Current Build 152

Released October 2, 2018

Organism
Homo sapiens
Position
chr11:27658369 (GRCh38.p12) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
C>T
Variation Type
SNV Single Nucleotide Variation
Frequency
T=0.19437 (47821/246030, GnomAD)
T=0.16433 (20634/125568, TOPMED)
T=0.19375 (23511/121350, ExAC) (+ 5 more)
T=0.1518 (4694/30928, GnomAD)
T=0.201 (1008/5008, 1000G)
T=0.153 (684/4480, Estonian)
T=0.180 (693/3854, ALSPAC)
T=0.193 (715/3708, TWINSUK)
Clinical Significance
Reported in ClinVar
Gene : Consequence
BDNF : Missense Variant
BDNF-AS : Non Coding Transcript Variant
Publications
435 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p12 chr 11 NC_000011.10:g.27658369C>T
GRCh37.p13 chr 11 NC_000011.9:g.27679916C>T
BDNF RefSeqGene NG_011794.1:g.68690G>A
Gene: BDNF, brain derived neurotrophic factor (minus strand)
Molecule type Change Amino acid[Codon] SO Term
BDNF transcript variant 3 NM_170731.4:c.220G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform b precursor NP_733927.1:p.Val74Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 2 NM_170732.4:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_733928.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 5 NM_170733.3:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_733929.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 4 NM_001709.4:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001700.2:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 6 NM_170734.3:c.241G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform c NP_733930.1:p.Val81Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 1 NM_170735.5:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_733931.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 7 NM_001143805.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137277.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 8 NM_001143806.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137278.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 9 NM_001143807.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137279.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 10 NM_001143808.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137280.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 17 NM_001143809.1:c.283G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform d NP_001137281.1:p.Val95Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 18 NM_001143810.1:c.442G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform e NP_001137282.1:p.Val148Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 11 NM_001143811.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137283.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 12 NM_001143812.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137284.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 13 NM_001143813.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137285.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 14 NM_001143814.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137286.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 16 NM_001143816.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137288.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant X1 XM_011520280.2:c.442G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform X1 XP_011518582.1:p.Val148Met V (Val) > M (Met) Missense Variant
Gene: BDNF-AS, BDNF antisense RNA (plus strand)
Molecule type Change Amino acid[Codon] SO Term
BDNF-AS transcript variant BT2B NR_002832.2:n.503C>T N/A Non Coding Transcript Variant
BDNF-AS transcript variant BT1C NR_033312.1:n.434C>T N/A Non Coding Transcript Variant
BDNF-AS transcript variant BT1A NR_033313.1:n.434C>T N/A Non Coding Transcript Variant
BDNF-AS transcript variant BT2A NR_033314.1:n.503C>T N/A Non Coding Transcript Variant
BDNF-AS transcript variant BT1B NR_033315.1:n.434C>T N/A Non Coding Transcript Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: T (allele ID: 32736 )
ClinVar Accession Disease Names Clinical Significance
RCV000019267.4 Memory impairment, susceptibility to Risk-Factor
RCV000155463.2 not specified Benign
Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study Population Group Sample Size Ref Allele Alt Allele
gnomAD - Exomes Global Study-wide 246030 C=0.80563 T=0.19437
gnomAD - Exomes European Sub 133792 C=0.81565 T=0.18435
gnomAD - Exomes Asian Sub 48028 C=0.6990 T=0.3010
gnomAD - Exomes American Sub 33582 C=0.8477 T=0.1523
gnomAD - Exomes African Sub 15300 C=0.9669 T=0.0331
gnomAD - Exomes Ashkenazi Jewish Sub 9846 C=0.784 T=0.216
gnomAD - Exomes Other Sub 5482 C=0.827 T=0.173
TopMed Global Study-wide 125568 C=0.83567 T=0.16433
ExAC Global Study-wide 121350 C=0.80625 T=0.19375
ExAC Europe Sub 73324 C=0.8110 T=0.1890
ExAC Asian Sub 25158 C=0.7055 T=0.2945
ExAC American Sub 11576 C=0.8500 T=0.1500
ExAC African Sub 10384 C=0.9653 T=0.0347
ExAC Other Sub 908 C=0.84 T=0.16
gnomAD - Genomes Global Study-wide 30928 C=0.8482 T=0.1518
gnomAD - Genomes European Sub 18474 C=0.8248 T=0.1752
gnomAD - Genomes African Sub 8720 C=0.964 T=0.036
gnomAD - Genomes East Asian Sub 1612 C=0.517 T=0.483
gnomAD - Genomes Other Sub 982 C=0.83 T=0.17
gnomAD - Genomes American Sub 838 C=0.85 T=0.15
gnomAD - Genomes Ashkenazi Jewish Sub 302 C=0.76 T=0.24
1000Genomes Global Study-wide 5008 C=0.799 T=0.201
1000Genomes African Sub 1322 C=0.989 T=0.011
1000Genomes East Asian Sub 1008 C=0.512 T=0.488
1000Genomes Europe Sub 1006 C=0.803 T=0.197
1000Genomes South Asian Sub 978 C=0.80 T=0.20
1000Genomes American Sub 694 C=0.85 T=0.15
Genetic variation in the Estonian population Estonian Study-wide 4480 C=0.847 T=0.153
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 C=0.820 T=0.180
UK 10K study - Twins TWIN COHORT Study-wide 3708 C=0.807 T=0.193
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement C= T Note
GRCh38.p12 chr 11 NC_000011.10:g.27658369C= NC_000011.10:g.27658369C>T
GRCh37.p13 chr 11 NC_000011.9:g.27679916C= NC_000011.9:g.27679916C>T
BDNF RefSeqGene NG_011794.1:g.68690G= NG_011794.1:g.68690G>A
BDNF transcript variant 1 NM_170735.5:c.196G= NM_170735.5:c.196G>A
BDNF transcript variant 3 NM_170731.4:c.220G= NM_170731.4:c.220G>A
BDNF transcript variant 2 NM_170732.4:c.196G= NM_170732.4:c.196G>A
BDNF transcript variant 4 NM_001709.4:c.196G= NM_001709.4:c.196G>A
BDNF transcript variant 5 NM_170733.3:c.196G= NM_170733.3:c.196G>A
BDNF transcript variant 6 NM_170734.3:c.241G= NM_170734.3:c.241G>A
BDNF transcript variant 16 NM_001143816.1:c.196G= NM_001143816.1:c.196G>A
BDNF transcript variant 11 NM_001143811.1:c.196G= NM_001143811.1:c.196G>A
BDNF transcript variant 14 NM_001143814.1:c.196G= NM_001143814.1:c.196G>A
BDNF transcript variant 18 NM_001143810.1:c.442G= NM_001143810.1:c.442G>A
BDNF transcript variant 8 NM_001143806.1:c.196G= NM_001143806.1:c.196G>A
BDNF transcript variant 13 NM_001143813.1:c.196G= NM_001143813.1:c.196G>A
BDNF transcript variant 9 NM_001143807.1:c.196G= NM_001143807.1:c.196G>A
BDNF transcript variant 12 NM_001143812.1:c.196G= NM_001143812.1:c.196G>A
BDNF transcript variant 7 NM_001143805.1:c.196G= NM_001143805.1:c.196G>A
BDNF transcript variant 17 NM_001143809.1:c.283G= NM_001143809.1:c.283G>A
BDNF transcript variant 10 NM_001143808.1:c.196G= NM_001143808.1:c.196G>A
BDNF transcript variant X1 XM_011520280.2:c.442G= XM_011520280.2:c.442G>A
BDNF-AS transcript variant BT2B NR_002832.2:n.503C= NR_002832.2:n.503C>T
BDNF-AS transcript variant BT1C NR_033312.1:n.434C= NR_033312.1:n.434C>T
BDNF-AS transcript variant BT2A NR_033314.1:n.503C= NR_033314.1:n.503C>T
BDNF-AS transcript variant BT1B NR_033315.1:n.434C= NR_033315.1:n.434C>T
BDNF-AS transcript variant BT1A NR_033313.1:n.434C= NR_033313.1:n.434C>T
brain-derived neurotrophic factor isoform a preproprotein NP_733931.1:p.Val66= NP_733931.1:p.Val66Met
brain-derived neurotrophic factor isoform b precursor NP_733927.1:p.Val74= NP_733927.1:p.Val74Met
brain-derived neurotrophic factor isoform a preproprotein NP_733928.1:p.Val66= NP_733928.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001700.2:p.Val66= NP_001700.2:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_733929.1:p.Val66= NP_733929.1:p.Val66Met
brain-derived neurotrophic factor isoform c NP_733930.1:p.Val81= NP_733930.1:p.Val81Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137288.1:p.Val66= NP_001137288.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137283.1:p.Val66= NP_001137283.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137286.1:p.Val66= NP_001137286.1:p.Val66Met
brain-derived neurotrophic factor isoform e NP_001137282.1:p.Val148= NP_001137282.1:p.Val148Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137278.1:p.Val66= NP_001137278.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137285.1:p.Val66= NP_001137285.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137279.1:p.Val66= NP_001137279.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137284.1:p.Val66= NP_001137284.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137277.1:p.Val66= NP_001137277.1:p.Val66Met
brain-derived neurotrophic factor isoform d NP_001137281.1:p.Val95= NP_001137281.1:p.Val95Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137280.1:p.Val66= NP_001137280.1:p.Val66Met
brain-derived neurotrophic factor isoform X1 XP_011518582.1:p.Val148= XP_011518582.1:p.Val148Met
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

146 SubSNP, 8 Frequency, 2 ClinVar submissions
No Submitter Submission ID Date (Build)
1 WIAF-CSNP ss7889 Sep 19, 2000 (52)
2 YUSUKE ss5015735 Aug 28, 2002 (108)
3 HG_BONN_CNS_SNPS ss12586728 Aug 26, 2003 (117)
4 SC_SNP ss16110854 Feb 27, 2004 (120)
5 CGAP-GAI ss16257509 Feb 27, 2004 (120)
6 CSHL-HAPMAP ss19221857 Feb 27, 2004 (120)
7 CSHL-HAPMAP ss19926147 Feb 27, 2004 (120)
8 SSAHASNP ss20799529 Apr 05, 2004 (121)
9 IMCJ-GDT ss22886806 Apr 05, 2004 (121)
10 PERLEGEN ss24149102 Sep 20, 2004 (123)
11 MGC_GENOME_DIFF ss28509849 Sep 24, 2004 (126)
12 ABI ss38790107 Mar 10, 2006 (126)
13 APPLERA_GI ss48423502 Mar 10, 2006 (126)
14 AFFY ss66120185 Nov 29, 2006 (127)
15 ILLUMINA ss66654688 Nov 29, 2006 (127)
16 ILLUMINA ss67448802 Nov 29, 2006 (127)
17 ILLUMINA ss67800191 Nov 29, 2006 (127)
18 PERLEGEN ss69313816 May 16, 2007 (127)
19 ILLUMINA ss70861507 May 26, 2008 (130)
20 ILLUMINA ss71448862 May 16, 2007 (127)
21 ILLUMINA ss75492161 Dec 05, 2007 (129)
22 AFFY ss76112437 Dec 05, 2007 (129)
23 CGM_KYOTO ss76872494 Dec 05, 2007 (129)
24 SI_EXO ss76884466 Dec 05, 2007 (129)
25 ILLUMINA ss79218547 Dec 15, 2007 (130)
26 KRIBB_YJKIM ss83347130 Dec 15, 2007 (130)
27 HGSV ss86044520 Dec 15, 2007 (130)
28 BCMHGSC_JDW ss88519571 Mar 23, 2008 (129)
29 HUMANGENOME_JCVI ss97463065 Feb 06, 2009 (130)
30 ILLUMINA ss122526781 Dec 01, 2009 (131)
31 ENSEMBL ss132391628 Dec 01, 2009 (131)
32 ENSEMBL ss137760330 Dec 01, 2009 (131)
33 ILLUMINA ss154356517 Dec 01, 2009 (131)
34 ILLUMINA ss159532780 Dec 01, 2009 (131)
35 SEATTLESEQ ss159722962 Dec 01, 2009 (131)
36 ILLUMINA ss160769670 Dec 01, 2009 (131)
37 COMPLETE_GENOMICS ss168106615 Jul 04, 2010 (132)
38 COMPLETE_GENOMICS ss170723311 Jul 04, 2010 (132)
39 ILLUMINA ss172111436 Jul 04, 2010 (132)
40 AFFY ss172543408 Jul 04, 2010 (132)
41 ILLUMINA ss173991729 Jul 04, 2010 (132)
42 PAGE_STUDY ss182258803 Jul 04, 2010 (132)
43 PAGE_STUDY ss182258834 Jul 04, 2010 (132)
44 1000GENOMES ss235499525 Jul 15, 2010 (132)
45 1000GENOMES ss242143891 Jul 15, 2010 (132)
46 OMICIA ss244238900 Aug 29, 2012 (137)
47 ILLUMINA ss244304653 Jul 04, 2010 (132)
48 OMIM-CURATED-RECORDS ss263197788 Nov 04, 2010 (133)
49 GMI ss280939109 May 04, 2012 (137)
50 GMI ss286344166 Apr 25, 2013 (138)
51 PJP ss291208569 May 09, 2011 (134)
52 NHLBI-ESP ss342321448 May 09, 2011 (134)
53 ILLUMINA ss410940482 Sep 17, 2011 (135)
54 PAGE_STUDY ss469415390 May 04, 2012 (137)
55 ILLUMINA ss481228852 May 04, 2012 (137)
56 ILLUMINA ss481252419 May 04, 2012 (137)
57 ILLUMINA ss482238829 Sep 08, 2015 (146)
58 ILLUMINA ss485409758 May 04, 2012 (137)
59 1000GENOMES ss491015044 May 04, 2012 (137)
60 EXOME_CHIP ss491448493 May 04, 2012 (137)
61 CLINSEQ_SNP ss491641794 May 04, 2012 (137)
62 ILLUMINA ss537344158 Sep 08, 2015 (146)
63 SSMP ss657957490 Apr 25, 2013 (138)
64 ILLUMINA ss778938426 Aug 21, 2014 (142)
65 ILLUMINA ss780896249 Sep 08, 2015 (146)
66 ILLUMINA ss783150338 Aug 21, 2014 (142)
67 ILLUMINA ss783582995 Sep 08, 2015 (146)
68 ILLUMINA ss784106321 Aug 21, 2014 (142)
69 ILLUMINA ss825549065 Jul 19, 2016 (147)
70 ILLUMINA ss832409527 Apr 01, 2015 (144)
71 ILLUMINA ss833044020 Aug 21, 2014 (142)
72 ILLUMINA ss833634848 Aug 21, 2014 (142)
73 ILLUMINA ss834400106 Aug 21, 2014 (142)
74 EVA-GONL ss988346220 Aug 21, 2014 (142)
75 JMKIDD_LAB ss1067521512 Aug 21, 2014 (142)
76 JMKIDD_LAB ss1077605940 Aug 21, 2014 (142)
77 1000GENOMES ss1340608745 Aug 21, 2014 (142)
78 HAMMER_LAB ss1397603702 Sep 08, 2015 (146)
79 DDI ss1426582936 Apr 01, 2015 (144)
80 EVA_GENOME_DK ss1575612641 Apr 01, 2015 (144)
81 EVA_FINRISK ss1584073819 Apr 01, 2015 (144)
82 EVA_DECODE ss1598022297 Apr 01, 2015 (144)
83 EVA_UK10K_ALSPAC ss1626250508 Apr 01, 2015 (144)
84 EVA_UK10K_TWINSUK ss1669244541 Apr 01, 2015 (144)
85 EVA_EXAC ss1690304714 Apr 01, 2015 (144)
86 EVA_MGP ss1711286917 Apr 01, 2015 (144)
87 EVA_SVP ss1713244242 Apr 01, 2015 (144)
88 ILLUMINA ss1752011944 Sep 08, 2015 (146)
89 ILLUMINA ss1752011945 Sep 08, 2015 (146)
90 ILLUMINA ss1917857738 Feb 12, 2016 (147)
91 WEILL_CORNELL_DGM ss1931707520 Feb 12, 2016 (147)
92 ILLUMINA ss1946306031 Feb 12, 2016 (147)
93 ILLUMINA ss1946306032 Feb 12, 2016 (147)
94 ILLUMINA ss1959336449 Feb 12, 2016 (147)
95 ILLUMINA ss1959336450 Feb 12, 2016 (147)
96 GENOMED ss1967328479 Jul 19, 2016 (147)
97 JJLAB ss2026601482 Sep 14, 2016 (149)
98 ILLUMINA ss2094790360 Dec 20, 2016 (150)
99 ILLUMINA ss2095021016 Dec 20, 2016 (150)
100 CSHL ss2136776518 Nov 08, 2017 (151)
101 USC_VALOUEV ss2154890065 Dec 20, 2016 (150)
102 HUMAN_LONGEVITY ss2181188897 Dec 20, 2016 (150)
103 TOPMED ss2344365953 Dec 20, 2016 (150)
104 SYSTEMSBIOZJU ss2627773729 Nov 08, 2017 (151)
105 ILLUMINA ss2632817982 Nov 08, 2017 (151)
106 ILLUMINA ss2632817983 Nov 08, 2017 (151)
107 ILLUMINA ss2632817984 Nov 08, 2017 (151)
108 ILLUMINA ss2635024532 Nov 08, 2017 (151)
109 GRF ss2699167918 Nov 08, 2017 (151)
110 ILLUMINA ss2710732189 Nov 08, 2017 (151)
111 GNOMAD ss2738870976 Nov 08, 2017 (151)
112 GNOMAD ss2748583287 Nov 08, 2017 (151)
113 GNOMAD ss2897700734 Nov 08, 2017 (151)
114 AFFY ss2984938208 Nov 08, 2017 (151)
115 AFFY ss2985583329 Nov 08, 2017 (151)
116 SWEGEN ss3007801784 Nov 08, 2017 (151)
117 ILLUMINA ss3021320974 Nov 08, 2017 (151)
118 ILLUMINA ss3021320975 Nov 08, 2017 (151)
119 EVA_SAMSUNG_MC ss3023066529 Nov 08, 2017 (151)
120 BIOINF_KMB_FNS_UNIBA ss3027099325 Nov 08, 2017 (151)
121 TOPMED ss3140205643 Nov 08, 2017 (151)
122 CSHL ss3349517651 Nov 08, 2017 (151)
123 ILLUMINA ss3625598510 Oct 12, 2018 (152)
124 ILLUMINA ss3626628211 Oct 12, 2018 (152)
125 ILLUMINA ss3626628212 Oct 12, 2018 (152)
126 ILLUMINA ss3630836302 Oct 12, 2018 (152)
127 ILLUMINA ss3632980783 Oct 12, 2018 (152)
128 ILLUMINA ss3633679710 Oct 12, 2018 (152)
129 ILLUMINA ss3634447257 Oct 12, 2018 (152)
130 ILLUMINA ss3634447258 Oct 12, 2018 (152)
131 ILLUMINA ss3635371481 Oct 12, 2018 (152)
132 ILLUMINA ss3636131800 Oct 12, 2018 (152)
133 ILLUMINA ss3637122310 Oct 12, 2018 (152)
134 ILLUMINA ss3637898466 Oct 12, 2018 (152)
135 ILLUMINA ss3638964746 Oct 12, 2018 (152)
136 ILLUMINA ss3639482955 Oct 12, 2018 (152)
137 ILLUMINA ss3640154596 Oct 12, 2018 (152)
138 ILLUMINA ss3640154597 Oct 12, 2018 (152)
139 ILLUMINA ss3642897586 Oct 12, 2018 (152)
140 ILLUMINA ss3644558838 Oct 12, 2018 (152)
141 ILLUMINA ss3644558839 Oct 12, 2018 (152)
142 OMUKHERJEE_ADBS ss3646423872 Oct 12, 2018 (152)
143 URBANLAB ss3649567984 Oct 12, 2018 (152)
144 ILLUMINA ss3651683878 Oct 12, 2018 (152)
145 ILLUMINA ss3651683879 Oct 12, 2018 (152)
146 ILLUMINA ss3653710073 Oct 12, 2018 (152)
147 1000Genomes NC_000011.9 - 27679916 Oct 12, 2018 (152)
148 The Avon Longitudinal Study of Parents and Children NC_000011.9 - 27679916 Oct 12, 2018 (152)
149 Genetic variation in the Estonian population NC_000011.9 - 27679916 Oct 12, 2018 (152)
150 ExAC NC_000011.9 - 27679916 Oct 12, 2018 (152)
151 gnomAD - Genomes NC_000011.9 - 27679916 Oct 12, 2018 (152)
152 gnomAD - Exomes NC_000011.9 - 27679916 Oct 12, 2018 (152)
153 TopMed NC_000011.10 - 27658369 Oct 12, 2018 (152)
154 UK 10K study - Twins NC_000011.9 - 27679916 Oct 12, 2018 (152)
155 ClinVar RCV000019267.4 Oct 12, 2018 (152)
156 ClinVar RCV000155463.2 Oct 12, 2018 (152)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs3829232 Oct 08, 2002 (108)
rs16917222 Oct 08, 2004 (123)
rs17855547 Mar 10, 2006 (126)
rs60760775 May 26, 2008 (130)
rs386602118 Jul 31, 2014 (136)
Added to this RefSNP Cluster:
Submission ids Observation SPDI Canonical SPDI Source RSIDs
ss66120185, ss76112437, ss86044520, ss88519571, ss168106615, ss170723311, ss172543408, ss280939109, ss286344166, ss291208569, ss410940482, ss481228852, ss491641794, ss825549065, ss1397603702, ss1598022297, ss1713244242, ss2136776518, ss2635024532, ss3638964746, ss3639482955, ss3642897586 NC_000011.8:27636491:C= NC_000011.10:27658368:C= (self)
53109772, 29503076, 20941949, 556161, 31402256, 6396233, 29503076, ss235499525, ss242143891, ss342321448, ss481252419, ss482238829, ss485409758, ss491015044, ss491448493, ss537344158, ss657957490, ss778938426, ss780896249, ss783150338, ss783582995, ss784106321, ss832409527, ss833044020, ss833634848, ss834400106, ss988346220, ss1067521512, ss1077605940, ss1340608745, ss1426582936, ss1575612641, ss1584073819, ss1626250508, ss1669244541, ss1690304714, ss1711286917, ss1752011944, ss1752011945, ss1917857738, ss1931707520, ss1946306031, ss1946306032, ss1959336449, ss1959336450, ss1967328479, ss2026601482, ss2094790360, ss2095021016, ss2154890065, ss2344365953, ss2627773729, ss2632817982, ss2632817983, ss2632817984, ss2699167918, ss2710732189, ss2738870976, ss2748583287, ss2897700734, ss2984938208, ss2985583329, ss3007801784, ss3021320974, ss3021320975, ss3023066529, ss3349517651, ss3625598510, ss3626628211, ss3626628212, ss3630836302, ss3632980783, ss3633679710, ss3634447257, ss3634447258, ss3635371481, ss3636131800, ss3637122310, ss3637898466, ss3640154596, ss3640154597, ss3644558838, ss3644558839, ss3646423872, ss3651683878, ss3651683879, ss3653710073 NC_000011.9:27679915:C= NC_000011.10:27658368:C= (self)
59625618, ss244238900, ss263197788, ss2181188897, ss3027099325, ss3140205643, ss3649567984 NC_000011.10:27658368:C= NC_000011.10:27658368:C= (self)
ss16110854, ss19221857, ss19926147, ss20799529 NT_009237.16:26443855:C= NC_000011.10:27658368:C= (self)
ss76884466 NT_009237.17:26467156:C= NC_000011.10:27658368:C= (self)
ss7889, ss5015735, ss12586728, ss16257509, ss22886806, ss24149102, ss28509849, ss38790107, ss48423502, ss66654688, ss67448802, ss67800191, ss69313816, ss70861507, ss71448862, ss75492161, ss76872494, ss79218547, ss83347130, ss97463065, ss122526781, ss132391628, ss137760330, ss154356517, ss159532780, ss159722962, ss160769670, ss172111436, ss173991729, ss182258803, ss182258834, ss244304653, ss469415390 NT_009237.18:27619915:C= NC_000011.10:27658368:C= (self)
ss66120185, ss76112437, ss86044520, ss88519571, ss168106615, ss170723311, ss172543408, ss280939109, ss286344166, ss291208569, ss410940482, ss481228852, ss491641794, ss825549065, ss1397603702, ss1598022297, ss1713244242, ss2136776518, ss2635024532, ss3638964746, ss3639482955, ss3642897586 NC_000011.8:27636491:C>T NC_000011.10:27658368:C>T (self)
53109772, 29503076, 20941949, 556161, 31402256, 6396233, 29503076, ss235499525, ss242143891, ss342321448, ss481252419, ss482238829, ss485409758, ss491015044, ss491448493, ss537344158, ss657957490, ss778938426, ss780896249, ss783150338, ss783582995, ss784106321, ss832409527, ss833044020, ss833634848, ss834400106, ss988346220, ss1067521512, ss1077605940, ss1340608745, ss1426582936, ss1575612641, ss1584073819, ss1626250508, ss1669244541, ss1690304714, ss1711286917, ss1752011944, ss1752011945, ss1917857738, ss1931707520, ss1946306031, ss1946306032, ss1959336449, ss1959336450, ss1967328479, ss2026601482, ss2094790360, ss2095021016, ss2154890065, ss2344365953, ss2627773729, ss2632817982, ss2632817983, ss2632817984, ss2699167918, ss2710732189, ss2738870976, ss2748583287, ss2897700734, ss2984938208, ss2985583329, ss3007801784, ss3021320974, ss3021320975, ss3023066529, ss3349517651, ss3625598510, ss3626628211, ss3626628212, ss3630836302, ss3632980783, ss3633679710, ss3634447257, ss3634447258, ss3635371481, ss3636131800, ss3637122310, ss3637898466, ss3640154596, ss3640154597, ss3644558838, ss3644558839, ss3646423872, ss3651683878, ss3651683879, ss3653710073 NC_000011.9:27679915:C>T NC_000011.10:27658368:C>T (self)
RCV000019267.4, RCV000155463.2, 59625618, ss244238900, ss263197788, ss2181188897, ss3027099325, ss3140205643, ss3649567984 NC_000011.10:27658368:C>T NC_000011.10:27658368:C>T (self)
ss16110854, ss19221857, ss19926147, ss20799529 NT_009237.16:26443855:C>T NC_000011.10:27658368:C>T (self)
ss76884466 NT_009237.17:26467156:C>T NC_000011.10:27658368:C>T (self)
ss7889, ss5015735, ss12586728, ss16257509, ss22886806, ss24149102, ss28509849, ss38790107, ss48423502, ss66654688, ss67448802, ss67800191, ss69313816, ss70861507, ss71448862, ss75492161, ss76872494, ss79218547, ss83347130, ss97463065, ss122526781, ss132391628, ss137760330, ss154356517, ss159532780, ss159722962, ss160769670, ss172111436, ss173991729, ss182258803, ss182258834, ss244304653, ss469415390 NT_009237.18:27619915:C>T NC_000011.10:27658368:C>T (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

435 citations for rs6265
PMID Title Author Year Journal
12140781 Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Sklar P et al. 2002 Molecular psychiatry
12161822 The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Neves-Pereira M et al. 2002 American journal of human genetics
12553913 The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Egan MF et al. 2003 Cell
12836135 Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Hall D et al. 2003 American journal of human genetics
12888803 Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Ribasés M et al. 2003 Molecular psychiatry
15115760 Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Ribasés M et al. 2004 Human molecular genetics
15337662 Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. Geller B et al. 2004 The American journal of psychiatry
15457498 Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Friedel S et al. 2005 American journal of medical genetics. Part B, Neuropsychiatric genetics
16005437 Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Schumacher J et al. 2005 Biological psychiatry
16152572 Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. Lohoff FW et al. 2005 American journal of medical genetics. Part B, Neuropsychiatric genetics
16172806 The role of G196A polymorphism in the brain-derived neurotrophic factor gene in the cause of Parkinson's disease: a meta-analysis. Zintzaras E et al. 2005 Journal of human genetics
16222333 Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder. Rybakowski JK et al. 2006 Molecular psychiatry
16344533 BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Karamohamed S et al. 2005 Neurology
16389585 The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study. Rosa A et al. 2006 American journal of medical genetics. Part B, Neuropsychiatric genetics
16497333 No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. Surtees PG et al. 2007 Journal of psychiatric research
16631352 No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population. Watanabe Y et al. 2006 Schizophrenia research
16741941 Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate. Kremeyer B et al. 2006 American journal of medical genetics. Part B, Neuropsychiatric genetics
16962786 Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease. Kishikawa S et al. 2006 Neurobiology of disease
17096834 No association between polymorphisms in the BDNF gene and age at onset in Huntington disease. Mai M et al. 2006 BMC medical genetics
17135278 Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Saccone SF et al. 2007 Human molecular genetics
17196936 Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis. Qian L et al. 2007 Biochemical and biophysical research communications
17212826 TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach. Cozza A et al. 2007 BMC genomics
17219016 No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD. Schimmelmann BG et al. 2007 Journal of neural transmission (Vienna, Austria
17293537 Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. Huang R et al. 2007 Journal of medical genetics
17417060 Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder. Kanazawa T et al. 2007 Psychiatric genetics
17483451 Gene-gene interaction associated with neural reward sensitivity. Yacubian J et al. 2007 Proceedings of the National Academy of Sciences of the United States of America
17503330 A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Lou XY et al. 2007 American journal of human genetics
17602759 Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis. Weinstock-Guttman B et al. 2007 Journal of neuroimmunology
17632285 The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Ribeiro L et al. 2007 Neuroreport
17653045 Candidate gene and locus analysis of myopia. Mutti DO et al. 2007 Molecular vision
17656372 Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor. Zivadinov R et al. 2007 Human molecular genetics
17657167 Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population. He XM et al. 2007 Neuropsychobiology
17894414 BDNF Val66Met variant and age of onset in schizophrenia. Chao HM et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
17918236 Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder. Lee J et al. 2007 American journal of medical genetics. Part B, Neuropsychiatric genetics
18205169 Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. Chen L et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
18478177 Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine. Marziniak M et al. 2008 Journal of neural transmission (Vienna, Austria
18534558 Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Li MD et al. 2008 Biological psychiatry
18565990 Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. Saccone SF et al. 2008 Bioinformatics (Oxford, England)
18600033 Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients. Sarchiapone M et al. 2008 Neuropsychobiology
18698231 Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. Johnson AD et al. 2008 Pharmacogenetics and genomics
18704161 Genetic variation in an individual human exome. Ng PC et al. 2008 PLoS genetics
18776599 Susceptibility genes for gentamicin-induced vestibular dysfunction. Roth SM et al. 2008 Journal of vestibular research
18779388 Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. Kavvoura FK et al. 2008 American journal of epidemiology
18813964 Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Kauwe JS et al. 2009 Neurogenetics
18830724 Assessment of Alzheimer's disease case-control associations using family-based methods. Schjeide BM et al. 2009 Neurogenetics
18852698 Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Verhagen M et al. 2010 Molecular psychiatry
18957941 Genome-wide association scan for five major dimensions of personality. Terracciano A et al. 2010 Molecular psychiatry
19018231 Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder. Liu L et al. 2008 Psychiatric genetics
19018715 Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients. Dmitrzak-Weglarz M et al. 2008 Pharmacogenomics
19209189 Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI. Shugart YY et al. 2009 European journal of human genetics
19236730 Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response. Domschke K et al. 2010 The international journal of neuropsychopharmacology
19258022 Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Boettiger CA et al. 2009 Pharmacology, biochemistry, and behavior
19295238 Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families. Szczepankiewicz A et al. 2009 International archives of allergy and immunology
19330778 Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population. Xu J et al. 2010 American journal of medical genetics. Part B, Neuropsychiatric genetics
19336781 Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes. Lencz T et al. 2009 The British journal of psychiatry
19359258 Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project. Goodyer IM et al. 2010 International journal of epidemiology
19388013 BDNF, relative preference, and reward circuitry responses to emotional communication. Gasic GP et al. 2009 American journal of medical genetics. Part B, Neuropsychiatric genetics
19403460 Pharmacogenetics of antidepressant response: an update. Drago A et al. 2009 Human genomics
19412541 Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. Li G et al. 2009 PloS one
19414708 Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Licinio J et al. 2009 Archives of general psychiatry
19424874 Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population. Gong P et al. 2009 Journal of molecular neuroscience
19461660 No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population. Otowa T et al. 2009 Journal of human genetics
19478790 The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Zhao J et al. 2009 Obesity (Silver Spring, Md.)
19530966 Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis. Sánchez-Romero MA et al. 2009 Pharmacogenomics
19582215 Association study between BDNF gene polymorphisms and autism by three-dimensional gel-based microarray. Cheng L et al. 2009 International journal of molecular sciences
19582565 Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. Gadow KD et al. 2009 Journal of autism and developmental disorders
19603419 Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations. Sánchez-Mora C et al. 2010 American journal of medical genetics. Part B, Neuropsychiatric genetics
19699537 Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent. Liu X et al. 2009 Psychiatry research
19721723 Brain-derived neurotrophic factor: role in depression and suicide. Dwivedi Y et al. 2009 Neuropsychiatric disease and treatment
19721846 Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants. Forero DA et al. 2009 Journal of psychiatry & neuroscience
19734545 A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC et al. 2009 Human molecular genetics
19797905 Allelic based gene-gene interaction in case-control studies. Jung J et al. 2010 Human heredity
19844571 Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities. Le Hellard S et al. 2009 PloS one
19895626 The effect of BDNF gene variants on asthma in German children. Zeilinger S et al. 2009 Allergy
19925205 Ebbinghaus revisited: influences of the BDNF Val66Met polymorphism on backward serial recall are modulated by human aging. Li SC et al. 2010 Journal of cognitive neuroscience
19940176 Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans. Blasi G et al. 2009 The Journal of neuroscience
19944766 A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. Meda SA et al. 2010 NeuroImage
19953912 [An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders]. Ye CY et al. 2009 Zhonghua yi xue za zhi
20004415 Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene. Juckel G et al. 2010 Journal of psychiatric research
20008943 Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study. Brent D et al. 2010 The American journal of psychiatry
20014955 Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression. Lin E et al. 2009 Rejuvenation research
20016225 Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients. Zou YF et al. 2010 Neuropsychobiology
20033742 Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population. Zhang K et al. 2010 Journal of neural transmission (Vienna, Austria
20042999 BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Terracciano A et al. 2010 Neuropsychopharmacology
20075215 A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Soliman F et al. 2010 Science (New York, N.Y.)
20087404 Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study. Xu M et al. 2010 European journal of human genetics
20124106 Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Kohli MA et al. 2010 Archives of general psychiatry
20125193 Common genetic variation and performance on standardized cognitive tests. Cirulli ET et al. 2010 European journal of human genetics
20127379 From monogenic to polygenic obesity: recent advances. Hinney A et al. 2010 European child & adolescent psychiatry
20147969 Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension. Hong KW et al. 2010 Journal of human hypertension
20159343 The genetics of major depression: moving beyond the monoamine hypothesis. Shyn SI et al. 2010 The Psychiatric clinics of North America
20172611 Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder. Hosang GM et al. 2010 Journal of affective disorders
20191112 The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives. Pinheiro AP et al. 2009 International journal of child and adolescent health
20226536 Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. Lavebratt C et al. 2010 Journal of affective disorders
20400928 Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR. Sheikh HI et al. 2010 Psychiatric genetics
20418890 Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Tobacco and Genetics Consortium. et al. 2010 Nature genetics
20426150 Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture. Chiang MC et al. 2009 Medical image computing and computer-assisted intervention
20456319 Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia. Novak G et al. 2010 Annals of human genetics
20478698 Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study. Ramasamy DP et al. 2011 Pathophysiology
20482942 Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory. Cathomas F et al. 2010 The international journal of neuropsychopharmacology
20493546 BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects. Karnik MS et al. 2010 Psychiatry research
20504254 Pharmacogenomics of suicidal events. Brent D et al. 2010 Pharmacogenomics
20534741 Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Corneveaux JJ et al. 2010 Human molecular genetics
20549395 Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies. Cornelis MC et al. 2010 Current psychiatry reports
20574532 Intermediate phenotypes identify divergent pathways to Alzheimer's disease. Shulman JM et al. 2010 PloS one
20633049 Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes? Middeldorp CM et al. 2010 Genes, brain, and behavior
20682308 The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder. Yang C et al. 2010 Brain research
20691427 Genetic associations of brain structural networks in schizophrenia: a preliminary study. Jagannathan K et al. 2010 Biological psychiatry
20702703 The role of the BDNF Val66Met polymorphism for the synchronization of error-specific neural networks. Beste C et al. 2010 The Journal of neuroscience
20712903 Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. Morgan AR et al. 2010 BMC medical genetics
20816195 Analyses of shared genetic factors between asthma and obesity in children. Melén E et al. 2010 The Journal of allergy and clinical immunology
20843981 Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Wu L et al. 2010 Diabetes
20951727 Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Balu DT et al. 2011 Neuroscience and biobehavioral reviews
20959432 BDNF and CGRP interaction: implications in migraine susceptibility. Lemos C et al. 2010 Cephalalgia
20966902 Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. Croteau-Chonka DC et al. 2011 Obesity (Silver Spring, Md.)
20981231 Pharmacogenomics of mood stabilizers in the treatment of bipolar disorder. Squassina A et al. 2010 Human genomics and proteomics
21037213 Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents. Goodyer IM et al. 2010 The British journal of psychiatry
21049304 Influence of candidate genes on attention problems in children: a longitudinal study. van Beijsterveldt CE et al. 2011 Behavior genetics
21085053 Database of genetic studies of bipolar disorder. Piletz JE et al. 2011 Psychiatric genetics
21097659 Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects. Walter NT et al. 2011 Psychosomatic medicine
21103954 Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population. Suchanek R et al. 2011 Journal of molecular neuroscience
21167606 The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidities. Neves FS et al. 2011 Journal of affective disorders
21172166 Pharmacogenetics of antidepressant response. Porcelli S et al. 2011 Journal of psychiatry & neuroscience
21188787 Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder. Kocabas NA et al. 2011 International clinical psychopharmacology
21215389 The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Juhasz G et al. 2011 Biological psychiatry
21253406 Effects of BDNF polymorphisms on antidepressant action. Tsai SJ et al. 2010 Psychiatry investigation
21253413 Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder. Cho SC et al. 2010 Psychiatry investigation
21300947 The brain-derived neurotrophic factor Val66Met polymorphism and prediction of neural risk for Alzheimer disease. Voineskos AN et al. 2011 Archives of general psychiatry
21302343 The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. Rizzi TS et al. 2011 American journal of medical genetics. Part B, Neuropsychiatric genetics
21305693 Age at onset of psychotic disorder: cannabis, BDNF Val66Met, and sex-specific models of gene-environment interaction. Decoster J et al. 2011 American journal of medical genetics. Part B, Neuropsychiatric genetics
21333900 The role of genetics in IBS. Saito YA et al. 2011 Gastroenterology clinics of North America
21357383 No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies. Chen F et al. 2011 Cancer epidemiology, biomarkers & prevention
21432600 Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD. Arcos-Burgos M et al. 2010 Attention deficit and hyperactivity disorders
21436384 Genetic variability of smoking persistence in African Americans. Hamidovic A et al. 2011 Cancer prevention research (Philadelphia, Pa.)
21458533 Polymorphisms of brain-derived neurotrophic factor associated with heroin dependence. Jia W et al. 2011 Neuroscience letters
21466928 Genetics and epigenetics of obesity. Herrera BM et al. 2011 Maturitas
21491204 Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF. Valente NL et al. 2011 Journal of molecular neuroscience
21509595 Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system. Gruber O et al. 2012 European archives of psychiatry and clinical neuroscience
21537449 Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis. Webster J et al. 2010 International journal of molecular epidemiology and genetics
21577214 BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects. Gerritsen L et al. 2012 Molecular psychiatry
21640793 Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients. Serý O et al. 2011 Neuroscience letters
21641949 Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in an Armenian population. Zakharyan R et al. 2011 Human immunology
21687501 Pharmacogenetics of antidepressants. Crisafulli C et al. 2011 Frontiers in pharmacology
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27486327 Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine. Coskun S et al. 2016 Neuropsychiatric disease and treatment
27551971 The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children. Jasińska KK et al. 2016 PloS one
27553771 Interaction of BDNF rs6265 variants and energy and protein intake in the risk for glucose intolerance and type 2 diabetes in middle-aged adults. Daily JW et al. 2017 Nutrition (Burbank, Los Angeles County, Calif.)
27596955 Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples. de Castro-Catala M et al. 2016 Journal of psychiatric research
27647760 The relationship between polymorphisms of BDNFOS and BDNF genes and heroin addiction in the Han Chinese population. Jin T et al. 2016 The journal of gene medicine
27676367 A Population-Based Study of Four Genes Associated with Heroin Addiction in Han Chinese. Li Y et al. 2016 PloS one
27701469 Impact of TNF-α (rs1800629) and IL-6 (rs1800795) Polymorphisms on Cognitive Impairment in Asian Breast Cancer Patients. Chae JW et al. 2016 PloS one
27712141 Expression and methylation of BDNF in the human brain in schizophrenia. Cheah SY et al. 2017 The world journal of biological psychiatry
27720787 Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery. Eshragh J et al. 2017 Journal of pain and symptom management
27721799 Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions. Mirkovic B et al. 2016 Frontiers in psychiatry
27845333 Habitual coffee consumption and risk of type 2 diabetes, ischemic heart disease, depression and Alzheimer's disease: a Mendelian randomization study. Kwok MK et al. 2016 Scientific reports
27895608 Genetic Consideration of Schizotypal Traits: A Review. Walter EE et al. 2016 Frontiers in psychology
27939343 Stress-induced change in serum BDNF is related to quantitative family history of alcohol use disorder and age at first alcohol use. Sharma S et al. 2017 Pharmacology, biochemistry, and behavior
28100103 Systematic Review of Genetic Risk Factors for Sustaining a Mild Traumatic Brain Injury. Panenka WJ et al. 2017 Journal of neurotrauma
28123819 Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers. Vulturar R et al. 2016 Translational neuroscience
28127926 5-HTTLPR and DISC1 risk genotypes for elevated PTSD symptoms in US military veterans. Young KA et al. 2017 World psychiatry
28142104 A genetic risk factor for major depression and suicidal ideation is mitigated by physical activity. Taylor MK et al. 2017 Psychiatry research
28150221 The association between brain-derived neurotrophic factor gene polymorphism and migraine: a meta-analysis. Cai X et al. 2017 The journal of headache and pain
28202203 Female-specific effect of the BDNF gene on Alzheimer's disease. Li GD et al. 2017 Neurobiology of aging
28237884 Effects of crack cocaine addiction and stress-related genes on peripheral BDNF levels. Rovaris DL et al. 2017 Journal of psychiatric research
28291539 The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients. Kotlęga D et al. 2017 Neurologia i neurochirurgia polska
28304362 BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort. Avgan N et al. 2017 International journal of molecular sciences
28317287 The BDNF polymorphism Val66Met may be predictive of swallowing improvement post pharyngeal electrical stimulation in dysphagic stroke patients. Essa H et al. 2017 Neurogastroenterology and motility
28327672 TOX and ADIPOQ Gene Polymorphisms Are Associated with Antipsychotic-Induced Weight Gain in Han Chinese. Li S et al. 2017 Scientific reports
28337122 Cerebrospinal Fluid Cortisol Mediates Brain-Derived Neurotrophic Factor Relationships to Mortality after Severe TBI: A Prospective Cohort Study. Munoz MJ et al. 2017 Frontiers in molecular neuroscience
28387675 DNA Methylation and Tag SNPs of the BDNF Gene in Conversion of Amnestic Mild Cognitive Impairment into Alzheimer's Disease: A Cross-Sectional Cohort Study. Xie B et al. 2017 Journal of Alzheimer's disease
28396685 Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children. Wu L et al. 2017 International journal of endocrinology
28413930 Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children. Ersig AL et al. 2017 Biological research for nursing
28498887 Sex Differences in Risk for Alzheimer's Disease Related to Neurotrophin Gene Polymorphisms: The Cache County Memory Study. Matyi J et al. 2017 The journals of gerontology. Series A, Biological sciences and medical sciences
28507530 Brain-Derived Neurotrophic Factor Val66Met Gene Polymorphism Impacts on Migraine Susceptibility: A Meta-analysis of Case-Control Studies. Terrazzino S et al. 2017 Frontiers in neurology
28533660 Genes, emotions and gut microbiota: The next frontier for the gastroenterologist. Panduro A et al. 2017 World journal of gastroenterology
28539884 The Analysis of Two BDNF Polymorphisms G196A/C270T in Chinese Sporadic Amyotrophic Lateral Sclerosis. Xu L et al. 2017 Frontiers in aging neuroscience
28589140 Brain-Derived Neurotropic Factor <i>Val66Met</i> Polymorphism and Posttraumatic Stress Disorder among Survivors of the 1998 Dongting Lake Flood in China. Dai W et al. 2017 BioMed research international
28650998 Functional annotation of Alzheimer's disease associated loci revealed by GWASs. Han Z et al. 2017 PloS one
28656803 Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression. Caldieraro MA et al. 2018 The world journal of biological psychiatry
28692418 Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese. Gao X et al. 2017 Omics
28693089 [Effect of genetic polymorphisms on change in body mass index and obesity status during childhood]. Zhang MX et al. 2017 Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
28696411 Combined study of genetic and epigenetic biomarker risperidone treatment efficacy in Chinese Han schizophrenia patients. Shi Y et al. 2017 Translational psychiatry
28738459 [Gene-gene interaction on central obesity in school-aged children in China]. Fu LW et al. 2017 Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
28755387 BDNF genotype is associated with hippocampal volume in mild traumatic brain injury. Hayes JP et al. 2018 Genes, brain, and behavior
28756290 Exploring the association between BDNF Val66Met polymorphism and suicidal behavior: Meta-analysis and systematic review. González-Castro TB et al. 2017 Journal of psychiatric research
28760212 Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort. Jiang R et al. 2017 American heart journal
28777866 [Association of Val66Met polymorphism of brain-derived neurotrophic factor gene with cognitive impairment and clinical symptoms in first episode schizophrenia]. Zhang C et al. 2017 Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
28805974 Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population. Katsarou MS et al. 2017 Pharmacology research & perspectives
28818006 The Role of the BDNF Val66Met Polymorphism in Recovery of Aphasia After Stroke. de Boer RGA et al. 2017 Neurorehabilitation and neural repair
28818748 Association of Brain-derived neurotrophic factor gene polymorphisms with body mass index: A systematic review and meta-analysis. Akbarian SA et al. 2018 Advances in medical sciences
28833437 Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε-4 allele. Cintra MTG et al. 2018 International journal of geriatric psychiatry
28887539 Neurogenetic plasticity and sex influence the link between corticolimbic structural connectivity and trait anxiety. Kim MJ et al. 2017 Scientific reports
28927418 A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson's disease. Guin D et al. 2017 BMC medical genomics
28960774 The BDNF Val66Met polymorphism is associated with lower BMI, lower postprandial glucose levels and elevated carbohydrate intake in children and adolescents. Kalenda A et al. 2018 Pediatric obesity
28977521 The Impact of BDNF Polymorphisms on Suicidality in Treatment-Resistant Major Depressive Disorder: A European Multicenter Study. Schosser A et al. 2017 The international journal of neuropsychopharmacology
29028593 Genetic variations in the p11/tPA/BDNF pathway are associated with post stroke depression. Liang J et al. 2018 Journal of affective disorders
29039254 The antidepressant efficacy of subanesthetic-dose ketamine does not correlate with baseline subcortical volumes in a replication sample with major depressive disorder. Niciu MJ et al. 2017 Journal of psychopharmacology (Oxford, England)
29052254 Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease. Lang BM et al. 2018 Alimentary pharmacology & therapeutics
29079096 BDNF gene and obsessive compulsive disorder risk, symptom dimensions and treatment response. Taj M J RJ et al. 2018 Asian journal of psychiatry
29084453 Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice. Dincheva I et al. 2017 The American journal of psychiatry
29120944 Targeted Genotyping Identifies Susceptibility Locus in Brain-derived Neurotrophic Factor Gene for Chronic Postsurgical Pain. Tian Y et al. 2018 Anesthesiology
29191473 Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease. Kusters CDJ et al. 2018 Parkinsonism & related disorders
29249680 Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease. Miller NS et al. 2018 Parkinsonism & related disorders
29288745 A translational approach to the genetics of anxiety disorders. McGregor NW et al. 2018 Behavioural brain research
29288952 Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. de Araujo CM et al. 2018 Journal of psychiatric research
29306772 Interaction between BDNF and TNF-α genes in schizophrenia. Zhang Y et al. 2018 Psychoneuroendocrinology
29338492 Genetic variation of GRIA3 gene is associated with vulnerability to methamphetamine dependence and its associated psychosis. Iamjan SA et al. 2018 Journal of psychopharmacology (Oxford, England)
29357818 The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury. Wang YJ et al. 2018 BMC medical genetics
29369497 Pharmacogenetics of Risperidone-Induced Insulin Resistance in Children and Adolescents with Autism Spectrum Disorder. Sukasem C et al. 2018 Basic & clinical pharmacology & toxicology
29449128 Meta-Analysis on the Association between Brain-Derived Neurotrophic Factor Polymorphism rs6265 and Ischemic Stroke, Poststroke Depression. Bao MH et al. 2018 Journal of stroke and cerebrovascular diseases
29506764 Association Between the Brain-derived Neurotrophic Factor Val66Met Polymorphism and Overweight/Obesity in Pediatric Population. Martínez-Ezquerro JD et al. 2017 Archives of medical research
29551049 Correlations of Four Genetic Single Nucleotide Polymorphisms in Brain-Derived Neurotrophic Factor with Posttraumatic Stress Disorder. Guo JC et al. 2018 Psychiatry investigation
29684863 Psychological and genetic risk factors associated with suicidal behavior in Korean patients with mood disorders. Choi HY et al. 2018 Journal of affective disorders
29713173 Significant association of <i>BDNF</i> rs6265 G&gt;A polymorphism with susceptibility to epilepsy: a meta-analysis. Xu YL et al. 2018 Neuropsychiatric disease and treatment
29725086 Gene-based analysis of genes related to neurotrophic pathway suggests association of BDNF and VEGFA with antidepressant treatment-response in depressed patients. Kao CF et al. 2018 Scientific reports
29759928 Bdnf variant is associated with milder motor symptom severity in early-stage Parkinson's disease. Fischer DL et al. 2018 Parkinsonism & related disorders
29802070 BDNF plasma levels and genotype in depression and the response to electroconvulsive therapy. Ryan KM et al. 2018 Brain stimulation
29858545 Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A systematic review. Toh YL et al. 2018 Brain and behavior
29867348 Critical Issues in <i>BDNF</i> Val66Met Genetic Studies of Neuropsychiatric Disorders. Tsai SJ et al. 2018 Frontiers in molecular neuroscience
29898578 196G/A of the Brain-Derived Neurotrophic Factor Gene Polymorphisms Predicts Suicidal Behavior in Schizophrenia Patients. Kim EJ et al. 2018 Psychiatry investigation
29909994 The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Giza JI et al. 2018 Neuron
29935919 Increased expression of BDNF mRNA in the frontal cortex of autistic patients. Maussion G et al. 2019 Behavioural brain research
30014553 Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer's disease. Lim YY et al. 2018 Annals of neurology
30015148 BDNF Val66Met polymorphism is not related with temporal lobe epilepsy caused by hippocampal sclerosis in Brazilian population. Alcantara JA et al. 2018 Seizure
30017710 Childhood trauma and emotion regulation: The moderator role of BDNF Val66Met. Bîlc MI et al. 2018 Neuroscience letters
30026692 The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults. Jiang J et al. 2018 Frontiers in aging neuroscience
30041166 Temperament and Character Inventory in Bipolar Disorder versus Healthy Controls and Modulatory Effects of 3 Key Functional Gene Variants. Porcelli S et al. 2017 Neuropsychobiology
30076879 The association of BDNF gene polymorphism with cognitive impairment in insomnia patients. Zaki NFW et al. 2019 Progress in neuro-psychopharmacology & biological psychiatry
30083112 Genetics Factors in Major Depression Disease. Shadrina M et al. 2018 Frontiers in psychiatry
30093869 Biological Predictors of Clozapine Response: A Systematic Review. Samanaite R et al. 2018 Frontiers in psychiatry
30129980 The association between polymorphism of the BDNF gene and cigarette smoking in the Iranian population. Rajabi A et al. 2018 The journal of gene medicine

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
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