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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs6265

Current Build 155

Released April 9, 2021

Organism
Homo sapiens
Position
chr11:27658369 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
C>T
Variation Type
SNV Single Nucleotide Variation
Frequency
T=0.190935 (71760/375834, ALFA)
T=0.151052 (39982/264690, TOPMED)
T=0.194877 (48968/251276, GnomAD_exome) (+ 25 more)
T=0.145326 (20366/140140, GnomAD)
T=0.193745 (23511/121350, ExAC)
T=0.14425 (11352/78698, PAGE_STUDY)
T=0.40888 (6852/16758, 8.3KJPN)
T=0.2013 (1008/5008, 1000G)
T=0.1527 (684/4480, Estonian)
T=0.1798 (693/3854, ALSPAC)
T=0.1928 (715/3708, TWINSUK)
T=0.4481 (1313/2930, KOREAN)
T=0.2022 (421/2082, HGDP_Stanford)
T=0.4656 (853/1832, Korea1K)
T=0.1881 (322/1712, HapMap)
T=0.1444 (164/1136, Daghestan)
T=0.206 (206/998, GoNL)
T=0.115 (72/626, Chileans)
C=0.490 (300/612, Vietnamese)
T=0.205 (123/600, NorthernSweden)
T=0.227 (121/534, MGP)
T=0.168 (51/304, FINRISK)
T=0.125 (27/216, Qatari)
C=0.417 (75/180, SGDP_PRJ)
T=0.36 (34/94, Ancient Sardinia)
T=0.23 (9/40, GENOME_DK)
C=0.50 (6/12, Siberian)
T=0.50 (6/12, Siberian)
Clinical Significance
Reported in ClinVar
Gene : Consequence
BDNF : Missense Variant
BDNF-AS : Non Coding Transcript Variant
Publications
553 citations
Genomic View
See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 375834 C=0.809065 T=0.190935
European Sub 325872 C=0.806080 T=0.193920
African Sub 12394 C=0.95659 T=0.04341
African Others Sub 422 C=0.988 T=0.012
African American Sub 11972 C=0.95548 T=0.04452
Asian Sub 4062 C=0.5551 T=0.4449
East Asian Sub 3230 C=0.5464 T=0.4536
Other Asian Sub 832 C=0.589 T=0.411
Latin American 1 Sub 1572 C=0.8518 T=0.1482
Latin American 2 Sub 5338 C=0.8329 T=0.1671
South Asian Sub 5238 C=0.8087 T=0.1913
Other Sub 21358 C=0.80827 T=0.19173


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
Allele Frequency Aggregator Total Global 375834 C=0.809065 T=0.190935
Allele Frequency Aggregator European Sub 325872 C=0.806080 T=0.193920
Allele Frequency Aggregator Other Sub 21358 C=0.80827 T=0.19173
Allele Frequency Aggregator African Sub 12394 C=0.95659 T=0.04341
Allele Frequency Aggregator Latin American 2 Sub 5338 C=0.8329 T=0.1671
Allele Frequency Aggregator South Asian Sub 5238 C=0.8087 T=0.1913
Allele Frequency Aggregator Asian Sub 4062 C=0.5551 T=0.4449
Allele Frequency Aggregator Latin American 1 Sub 1572 C=0.8518 T=0.1482
TopMed Global Study-wide 264690 C=0.848948 T=0.151052
gnomAD - Exomes Global Study-wide 251276 C=0.805123 T=0.194877
gnomAD - Exomes European Sub 135210 C=0.815901 T=0.184099
gnomAD - Exomes Asian Sub 49008 C=0.69458 T=0.30542
gnomAD - Exomes American Sub 34592 C=0.84788 T=0.15212
gnomAD - Exomes African Sub 16254 C=0.96665 T=0.03335
gnomAD - Exomes Ashkenazi Jewish Sub 10076 C=0.78374 T=0.21626
gnomAD - Exomes Other Sub 6136 C=0.8167 T=0.1833
gnomAD - Genomes Global Study-wide 140140 C=0.854674 T=0.145326
gnomAD - Genomes European Sub 75878 C=0.81605 T=0.18395
gnomAD - Genomes African Sub 42016 C=0.96123 T=0.03877
gnomAD - Genomes American Sub 13652 C=0.84068 T=0.15932
gnomAD - Genomes Ashkenazi Jewish Sub 3322 C=0.7812 T=0.2188
gnomAD - Genomes East Asian Sub 3128 C=0.5153 T=0.4847
gnomAD - Genomes Other Sub 2144 C=0.8316 T=0.1684
ExAC Global Study-wide 121350 C=0.806255 T=0.193745
ExAC Europe Sub 73324 C=0.81100 T=0.18900
ExAC Asian Sub 25158 C=0.70550 T=0.29450
ExAC American Sub 11576 C=0.85003 T=0.14997
ExAC African Sub 10384 C=0.96533 T=0.03467
ExAC Other Sub 908 C=0.837 T=0.163
The PAGE Study Global Study-wide 78698 C=0.85575 T=0.14425
The PAGE Study AfricanAmerican Sub 32514 C=0.95488 T=0.04512
The PAGE Study Mexican Sub 10810 C=0.83802 T=0.16198
The PAGE Study Asian Sub 8318 C=0.5808 T=0.4192
The PAGE Study PuertoRican Sub 7916 C=0.8560 T=0.1440
The PAGE Study NativeHawaiian Sub 4534 C=0.6621 T=0.3379
The PAGE Study Cuban Sub 4230 C=0.8407 T=0.1593
The PAGE Study Dominican Sub 3828 C=0.8945 T=0.1055
The PAGE Study CentralAmerican Sub 2450 C=0.8931 T=0.1069
The PAGE Study SouthAmerican Sub 1982 C=0.8648 T=0.1352
The PAGE Study NativeAmerican Sub 1260 C=0.8468 T=0.1532
The PAGE Study SouthAsian Sub 856 C=0.797 T=0.203
8.3KJPN JAPANESE Study-wide 16758 C=0.59112 T=0.40888
1000Genomes Global Study-wide 5008 C=0.7987 T=0.2013
1000Genomes African Sub 1322 C=0.9894 T=0.0106
1000Genomes East Asian Sub 1008 C=0.5119 T=0.4881
1000Genomes Europe Sub 1006 C=0.8032 T=0.1968
1000Genomes South Asian Sub 978 C=0.798 T=0.202
1000Genomes American Sub 694 C=0.847 T=0.153
Genetic variation in the Estonian population Estonian Study-wide 4480 C=0.8473 T=0.1527
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 C=0.8202 T=0.1798
UK 10K study - Twins TWIN COHORT Study-wide 3708 C=0.8072 T=0.1928
KOREAN population from KRGDB KOREAN Study-wide 2930 C=0.5519 T=0.4481
HGDP-CEPH-db Supplement 1 Global Study-wide 2082 C=0.7978 T=0.2022
HGDP-CEPH-db Supplement 1 Est_Asia Sub 470 C=0.581 T=0.419
HGDP-CEPH-db Supplement 1 Central_South_Asia Sub 414 C=0.855 T=0.145
HGDP-CEPH-db Supplement 1 Middle_Est Sub 350 C=0.846 T=0.154
HGDP-CEPH-db Supplement 1 Europe Sub 318 C=0.805 T=0.195
HGDP-CEPH-db Supplement 1 Africa Sub 242 C=0.992 T=0.008
HGDP-CEPH-db Supplement 1 America Sub 216 C=0.829 T=0.171
HGDP-CEPH-db Supplement 1 Oceania Sub 72 C=0.88 T=0.12
Korean Genome Project KOREAN Study-wide 1832 C=0.5344 T=0.4656
HapMap Global Study-wide 1712 C=0.8119 T=0.1881
HapMap American Sub 770 C=0.770 T=0.230
HapMap African Sub 512 C=0.992 T=0.008
HapMap Asian Sub 254 C=0.614 T=0.386
HapMap Europe Sub 176 C=0.756 T=0.244
Genome-wide autozygosity in Daghestan Global Study-wide 1136 C=0.8556 T=0.1444
Genome-wide autozygosity in Daghestan Daghestan Sub 628 C=0.869 T=0.131
Genome-wide autozygosity in Daghestan Near_East Sub 144 C=0.812 T=0.188
Genome-wide autozygosity in Daghestan Central Asia Sub 122 C=0.811 T=0.189
Genome-wide autozygosity in Daghestan Europe Sub 108 C=0.861 T=0.139
Genome-wide autozygosity in Daghestan South Asian Sub 98 C=0.89 T=0.11
Genome-wide autozygosity in Daghestan Caucasus Sub 36 C=0.83 T=0.17
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 C=0.794 T=0.206
Chileans Chilean Study-wide 626 C=0.885 T=0.115
A Vietnamese Genetic Variation Database Global Study-wide 612 C=0.490 T=0.510
Northern Sweden ACPOP Study-wide 600 C=0.795 T=0.205
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 C=0.773 T=0.227
FINRISK Finnish from FINRISK project Study-wide 304 C=0.832 T=0.168
Qatari Global Study-wide 216 C=0.875 T=0.125
SGDP_PRJ Global Study-wide 180 C=0.417 T=0.583
Ancient Sardinia genome-wide 1240k capture data generation and analysis Global Study-wide 94 C=0.64 T=0.36
The Danish reference pan genome Danish Study-wide 40 C=0.78 T=0.23
Siberian Global Study-wide 12 C=0.50 T=0.50
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 11 NC_000011.10:g.27658369C>T
GRCh37.p13 chr 11 NC_000011.9:g.27679916C>T
BDNF RefSeqGene NG_011794.1:g.68690G>A
Gene: BDNF, brain derived neurotrophic factor (minus strand)
Molecule type Change Amino acid[Codon] SO Term
BDNF transcript variant 2 NM_170732.4:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_733928.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 7 NM_001143805.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137277.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 8 NM_001143806.1:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137278.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 4 NM_001709.5:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001700.2:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 13 NM_001143813.2:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137285.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 3 NM_170731.5:c.220G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform b precursor NP_733927.1:p.Val74Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 9 NM_001143807.2:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137279.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 14 NM_001143814.2:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137286.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 10 NM_001143808.2:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137280.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 1 NM_170735.6:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_733931.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 16 NM_001143816.2:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137288.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 5 NM_170733.4:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_733929.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 11 NM_001143811.2:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137283.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 12 NM_001143812.2:c.196G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform a preproprotein NP_001137284.1:p.Val66Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 17 NM_001143809.2:c.283G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform d NP_001137281.1:p.Val95Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 18 NM_001143810.2:c.442G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform e NP_001137282.1:p.Val148Met V (Val) > M (Met) Missense Variant
BDNF transcript variant 6 NM_170734.4:c.241G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform c NP_733930.1:p.Val81Met V (Val) > M (Met) Missense Variant
BDNF transcript variant X1 XM_011520280.2:c.442G>A V [GTG] > M [ATG] Coding Sequence Variant
brain-derived neurotrophic factor isoform X1 XP_011518582.1:p.Val148Met V (Val) > M (Met) Missense Variant
Gene: BDNF-AS, BDNF antisense RNA (plus strand)
Molecule type Change Amino acid[Codon] SO Term
BDNF-AS transcript variant BT2B NR_002832.2:n.503C>T N/A Non Coding Transcript Variant
BDNF-AS transcript variant BT1C NR_033312.1:n.434C>T N/A Non Coding Transcript Variant
BDNF-AS transcript variant BT1A NR_033313.1:n.434C>T N/A Non Coding Transcript Variant
BDNF-AS transcript variant BT2A NR_033314.1:n.503C>T N/A Non Coding Transcript Variant
BDNF-AS transcript variant BT1B NR_033315.1:n.434C>T N/A Non Coding Transcript Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: T (allele ID: 32736 )
ClinVar Accession Disease Names Clinical Significance
RCV000019267.5 Memory impairment, susceptibility to Risk-Factor
RCV000155463.2 not specified Benign
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement C= T
GRCh38.p13 chr 11 NC_000011.10:g.27658369= NC_000011.10:g.27658369C>T
GRCh37.p13 chr 11 NC_000011.9:g.27679916= NC_000011.9:g.27679916C>T
BDNF RefSeqGene NG_011794.1:g.68690= NG_011794.1:g.68690G>A
BDNF transcript variant 1 NM_170735.6:c.196= NM_170735.6:c.196G>A
BDNF transcript variant 1 NM_170735.5:c.196= NM_170735.5:c.196G>A
BDNF transcript variant 3 NM_170731.5:c.220= NM_170731.5:c.220G>A
BDNF transcript variant 3 NM_170731.4:c.220= NM_170731.4:c.220G>A
BDNF transcript variant 4 NM_001709.5:c.196= NM_001709.5:c.196G>A
BDNF transcript variant 4 NM_001709.4:c.196= NM_001709.4:c.196G>A
BDNF transcript variant 2 NM_170732.4:c.196= NM_170732.4:c.196G>A
BDNF transcript variant 5 NM_170733.4:c.196= NM_170733.4:c.196G>A
BDNF transcript variant 5 NM_170733.3:c.196= NM_170733.3:c.196G>A
BDNF transcript variant 6 NM_170734.4:c.241= NM_170734.4:c.241G>A
BDNF transcript variant 6 NM_170734.3:c.241= NM_170734.3:c.241G>A
BDNF transcript variant 16 NM_001143816.2:c.196= NM_001143816.2:c.196G>A
BDNF transcript variant 16 NM_001143816.1:c.196= NM_001143816.1:c.196G>A
BDNF transcript variant 11 NM_001143811.2:c.196= NM_001143811.2:c.196G>A
BDNF transcript variant 11 NM_001143811.1:c.196= NM_001143811.1:c.196G>A
BDNF transcript variant 14 NM_001143814.2:c.196= NM_001143814.2:c.196G>A
BDNF transcript variant 14 NM_001143814.1:c.196= NM_001143814.1:c.196G>A
BDNF transcript variant 18 NM_001143810.2:c.442= NM_001143810.2:c.442G>A
BDNF transcript variant 18 NM_001143810.1:c.442= NM_001143810.1:c.442G>A
BDNF transcript variant 13 NM_001143813.2:c.196= NM_001143813.2:c.196G>A
BDNF transcript variant 13 NM_001143813.1:c.196= NM_001143813.1:c.196G>A
BDNF transcript variant 12 NM_001143812.2:c.196= NM_001143812.2:c.196G>A
BDNF transcript variant 12 NM_001143812.1:c.196= NM_001143812.1:c.196G>A
BDNF transcript variant 17 NM_001143809.2:c.283= NM_001143809.2:c.283G>A
BDNF transcript variant 17 NM_001143809.1:c.283= NM_001143809.1:c.283G>A
BDNF transcript variant 10 NM_001143808.2:c.196= NM_001143808.2:c.196G>A
BDNF transcript variant 10 NM_001143808.1:c.196= NM_001143808.1:c.196G>A
BDNF transcript variant 9 NM_001143807.2:c.196= NM_001143807.2:c.196G>A
BDNF transcript variant 9 NM_001143807.1:c.196= NM_001143807.1:c.196G>A
BDNF transcript variant 8 NM_001143806.1:c.196= NM_001143806.1:c.196G>A
BDNF transcript variant 7 NM_001143805.1:c.196= NM_001143805.1:c.196G>A
BDNF transcript variant X1 XM_011520280.2:c.442= XM_011520280.2:c.442G>A
BDNF-AS transcript variant BT2B NR_002832.2:n.503= NR_002832.2:n.503C>T
BDNF transcript variant 15 NM_001143815.1:c.196= NM_001143815.1:c.196G>A
BDNF-AS transcript variant BT1C NR_033312.1:n.434= NR_033312.1:n.434C>T
BDNF-AS transcript variant BT2A NR_033314.1:n.503= NR_033314.1:n.503C>T
BDNF-AS transcript variant BT1B NR_033315.1:n.434= NR_033315.1:n.434C>T
BDNF-AS transcript variant BT1A NR_033313.1:n.434= NR_033313.1:n.434C>T
brain-derived neurotrophic factor isoform a preproprotein NP_733931.1:p.Val66= NP_733931.1:p.Val66Met
brain-derived neurotrophic factor isoform b precursor NP_733927.1:p.Val74= NP_733927.1:p.Val74Met
brain-derived neurotrophic factor isoform a preproprotein NP_001700.2:p.Val66= NP_001700.2:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_733928.1:p.Val66= NP_733928.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_733929.1:p.Val66= NP_733929.1:p.Val66Met
brain-derived neurotrophic factor isoform c NP_733930.1:p.Val81= NP_733930.1:p.Val81Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137288.1:p.Val66= NP_001137288.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137283.1:p.Val66= NP_001137283.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137286.1:p.Val66= NP_001137286.1:p.Val66Met
brain-derived neurotrophic factor isoform e NP_001137282.1:p.Val148= NP_001137282.1:p.Val148Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137285.1:p.Val66= NP_001137285.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137284.1:p.Val66= NP_001137284.1:p.Val66Met
brain-derived neurotrophic factor isoform d NP_001137281.1:p.Val95= NP_001137281.1:p.Val95Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137280.1:p.Val66= NP_001137280.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137279.1:p.Val66= NP_001137279.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137278.1:p.Val66= NP_001137278.1:p.Val66Met
brain-derived neurotrophic factor isoform a preproprotein NP_001137277.1:p.Val66= NP_001137277.1:p.Val66Met
brain-derived neurotrophic factor isoform X1 XP_011518582.1:p.Val148= XP_011518582.1:p.Val148Met
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

179 SubSNP, 29 Frequency, 2 ClinVar submissions
No Submitter Submission ID Date (Build)
1 WIAF-CSNP ss7889 Sep 19, 2000 (52)
2 YUSUKE ss5015735 Aug 28, 2002 (108)
3 HG_BONN_CNS_SNPS ss12586728 Aug 26, 2003 (117)
4 SC_SNP ss16110854 Feb 27, 2004 (120)
5 CGAP-GAI ss16257509 Feb 27, 2004 (120)
6 CSHL-HAPMAP ss19221857 Feb 27, 2004 (120)
7 CSHL-HAPMAP ss19926147 Feb 27, 2004 (120)
8 SSAHASNP ss20799529 Apr 05, 2004 (121)
9 IMCJ-GDT ss22886806 Apr 05, 2004 (121)
10 PERLEGEN ss24149102 Sep 20, 2004 (123)
11 MGC_GENOME_DIFF ss28509849 Sep 24, 2004 (126)
12 ABI ss38790107 Mar 10, 2006 (126)
13 APPLERA_GI ss48423502 Mar 10, 2006 (126)
14 AFFY ss66120185 Nov 29, 2006 (127)
15 ILLUMINA ss66654688 Nov 29, 2006 (127)
16 ILLUMINA ss67448802 Nov 29, 2006 (127)
17 ILLUMINA ss67800191 Nov 29, 2006 (127)
18 PERLEGEN ss69313816 May 16, 2007 (127)
19 ILLUMINA ss70861507 May 26, 2008 (130)
20 ILLUMINA ss71448862 May 16, 2007 (127)
21 ILLUMINA ss75492161 Dec 05, 2007 (129)
22 AFFY ss76112437 Dec 05, 2007 (129)
23 CGM_KYOTO ss76872494 Dec 05, 2007 (129)
24 SI_EXO ss76884466 Dec 05, 2007 (129)
25 ILLUMINA ss79218547 Dec 15, 2007 (130)
26 KRIBB_YJKIM ss83347130 Dec 15, 2007 (130)
27 HGSV ss86044520 Dec 15, 2007 (130)
28 BCMHGSC_JDW ss88519571 Mar 23, 2008 (129)
29 HUMANGENOME_JCVI ss97463065 Feb 06, 2009 (130)
30 ILLUMINA ss122526781 Dec 01, 2009 (131)
31 ENSEMBL ss132391628 Dec 01, 2009 (131)
32 ENSEMBL ss137760330 Dec 01, 2009 (131)
33 ILLUMINA ss154356517 Dec 01, 2009 (131)
34 ILLUMINA ss159532780 Dec 01, 2009 (131)
35 SEATTLESEQ ss159722962 Dec 01, 2009 (131)
36 ILLUMINA ss160769670 Dec 01, 2009 (131)
37 COMPLETE_GENOMICS ss168106615 Jul 04, 2010 (132)
38 COMPLETE_GENOMICS ss170723311 Jul 04, 2010 (132)
39 ILLUMINA ss172111436 Jul 04, 2010 (132)
40 AFFY ss172543408 Jul 04, 2010 (132)
41 ILLUMINA ss173991729 Jul 04, 2010 (132)
42 PAGE_STUDY ss182258803 Jul 04, 2010 (132)
43 PAGE_STUDY ss182258834 Jul 04, 2010 (132)
44 1000GENOMES ss235499525 Jul 15, 2010 (132)
45 1000GENOMES ss242143891 Jul 15, 2010 (132)
46 OMICIA ss244238900 Aug 29, 2012 (137)
47 ILLUMINA ss244304653 Jul 04, 2010 (132)
48 OMIM-CURATED-RECORDS ss263197788 Nov 04, 2010 (133)
49 GMI ss280939109 May 04, 2012 (137)
50 GMI ss286344166 Apr 25, 2013 (138)
51 PJP ss291208569 May 09, 2011 (134)
52 NHLBI-ESP ss342321448 May 09, 2011 (134)
53 ILLUMINA ss410940482 Sep 17, 2011 (135)
54 PAGE_STUDY ss469415390 May 04, 2012 (137)
55 ILLUMINA ss481228852 May 04, 2012 (137)
56 ILLUMINA ss481252419 May 04, 2012 (137)
57 ILLUMINA ss482238829 Sep 08, 2015 (146)
58 ILLUMINA ss485409758 May 04, 2012 (137)
59 1000GENOMES ss491015044 May 04, 2012 (137)
60 EXOME_CHIP ss491448493 May 04, 2012 (137)
61 CLINSEQ_SNP ss491641794 May 04, 2012 (137)
62 ILLUMINA ss537344158 Sep 08, 2015 (146)
63 SSMP ss657957490 Apr 25, 2013 (138)
64 ILLUMINA ss778938426 Aug 21, 2014 (142)
65 ILLUMINA ss780896249 Sep 08, 2015 (146)
66 ILLUMINA ss783150338 Aug 21, 2014 (142)
67 ILLUMINA ss783582995 Sep 08, 2015 (146)
68 ILLUMINA ss784106321 Aug 21, 2014 (142)
69 ILLUMINA ss825549065 Jul 19, 2016 (147)
70 ILLUMINA ss832409527 Apr 01, 2015 (144)
71 ILLUMINA ss833044020 Aug 21, 2014 (142)
72 ILLUMINA ss833634848 Aug 21, 2014 (142)
73 ILLUMINA ss834400106 Aug 21, 2014 (142)
74 EVA-GONL ss988346220 Aug 21, 2014 (142)
75 JMKIDD_LAB ss1067521512 Aug 21, 2014 (142)
76 JMKIDD_LAB ss1077605940 Aug 21, 2014 (142)
77 1000GENOMES ss1340608745 Aug 21, 2014 (142)
78 HAMMER_LAB ss1397603702 Sep 08, 2015 (146)
79 DDI ss1426582936 Apr 01, 2015 (144)
80 EVA_GENOME_DK ss1575612641 Apr 01, 2015 (144)
81 EVA_FINRISK ss1584073819 Apr 01, 2015 (144)
82 EVA_DECODE ss1598022297 Apr 01, 2015 (144)
83 EVA_UK10K_ALSPAC ss1626250508 Apr 01, 2015 (144)
84 EVA_UK10K_TWINSUK ss1669244541 Apr 01, 2015 (144)
85 EVA_EXAC ss1690304714 Apr 01, 2015 (144)
86 EVA_MGP ss1711286917 Apr 01, 2015 (144)
87 EVA_SVP ss1713244242 Apr 01, 2015 (144)
88 ILLUMINA ss1752011944 Sep 08, 2015 (146)
89 ILLUMINA ss1752011945 Sep 08, 2015 (146)
90 ILLUMINA ss1917857738 Feb 12, 2016 (147)
91 WEILL_CORNELL_DGM ss1931707520 Feb 12, 2016 (147)
92 ILLUMINA ss1946306031 Feb 12, 2016 (147)
93 ILLUMINA ss1946306032 Feb 12, 2016 (147)
94 ILLUMINA ss1959336449 Feb 12, 2016 (147)
95 ILLUMINA ss1959336450 Feb 12, 2016 (147)
96 GENOMED ss1967328479 Jul 19, 2016 (147)
97 JJLAB ss2026601482 Sep 14, 2016 (149)
98 ILLUMINA ss2094790360 Dec 20, 2016 (150)
99 ILLUMINA ss2095021016 Dec 20, 2016 (150)
100 CSHL ss2136776518 Nov 08, 2017 (151)
101 USC_VALOUEV ss2154890065 Dec 20, 2016 (150)
102 HUMAN_LONGEVITY ss2181188897 Dec 20, 2016 (150)
103 TOPMED ss2344365953 Dec 20, 2016 (150)
104 SYSTEMSBIOZJU ss2627773729 Nov 08, 2017 (151)
105 ILLUMINA ss2632817982 Nov 08, 2017 (151)
106 ILLUMINA ss2632817983 Nov 08, 2017 (151)
107 ILLUMINA ss2632817984 Nov 08, 2017 (151)
108 ILLUMINA ss2635024532 Nov 08, 2017 (151)
109 GRF ss2699167918 Nov 08, 2017 (151)
110 ILLUMINA ss2710732189 Nov 08, 2017 (151)
111 GNOMAD ss2738870976 Nov 08, 2017 (151)
112 GNOMAD ss2748583287 Nov 08, 2017 (151)
113 GNOMAD ss2897700734 Nov 08, 2017 (151)
114 AFFY ss2984938208 Nov 08, 2017 (151)
115 AFFY ss2985583329 Nov 08, 2017 (151)
116 SWEGEN ss3007801784 Nov 08, 2017 (151)
117 ILLUMINA ss3021320974 Nov 08, 2017 (151)
118 ILLUMINA ss3021320975 Nov 08, 2017 (151)
119 EVA_SAMSUNG_MC ss3023066529 Nov 08, 2017 (151)
120 BIOINF_KMB_FNS_UNIBA ss3027099325 Nov 08, 2017 (151)
121 TOPMED ss3140205643 Nov 08, 2017 (151)
122 CSHL ss3349517651 Nov 08, 2017 (151)
123 ILLUMINA ss3625598510 Oct 12, 2018 (152)
124 ILLUMINA ss3626628211 Oct 12, 2018 (152)
125 ILLUMINA ss3626628212 Oct 12, 2018 (152)
126 ILLUMINA ss3630836302 Oct 12, 2018 (152)
127 ILLUMINA ss3632980783 Oct 12, 2018 (152)
128 ILLUMINA ss3633679710 Oct 12, 2018 (152)
129 ILLUMINA ss3634447257 Oct 12, 2018 (152)
130 ILLUMINA ss3634447258 Oct 12, 2018 (152)
131 ILLUMINA ss3635371481 Oct 12, 2018 (152)
132 ILLUMINA ss3636131800 Oct 12, 2018 (152)
133 ILLUMINA ss3637122310 Oct 12, 2018 (152)
134 ILLUMINA ss3637898466 Oct 12, 2018 (152)
135 ILLUMINA ss3638964746 Oct 12, 2018 (152)
136 ILLUMINA ss3639482955 Oct 12, 2018 (152)
137 ILLUMINA ss3640154596 Oct 12, 2018 (152)
138 ILLUMINA ss3640154597 Oct 12, 2018 (152)
139 ILLUMINA ss3642897586 Oct 12, 2018 (152)
140 ILLUMINA ss3644558838 Oct 12, 2018 (152)
141 ILLUMINA ss3644558839 Oct 12, 2018 (152)
142 OMUKHERJEE_ADBS ss3646423872 Oct 12, 2018 (152)
143 URBANLAB ss3649567984 Oct 12, 2018 (152)
144 ILLUMINA ss3651683878 Oct 12, 2018 (152)
145 ILLUMINA ss3651683879 Oct 12, 2018 (152)
146 ILLUMINA ss3653710073 Oct 12, 2018 (152)
147 EGCUT_WGS ss3675203701 Jul 13, 2019 (153)
148 EVA_DECODE ss3691459786 Jul 13, 2019 (153)
149 ILLUMINA ss3725228031 Jul 13, 2019 (153)
150 ACPOP ss3738036625 Jul 13, 2019 (153)
151 ILLUMINA ss3744082850 Jul 13, 2019 (153)
152 ILLUMINA ss3744378325 Jul 13, 2019 (153)
153 ILLUMINA ss3744748154 Jul 13, 2019 (153)
154 ILLUMINA ss3744748155 Jul 13, 2019 (153)
155 EVA ss3749096546 Jul 13, 2019 (153)
156 PAGE_CC ss3771614886 Jul 13, 2019 (153)
157 ILLUMINA ss3772248191 Jul 13, 2019 (153)
158 ILLUMINA ss3772248192 Jul 13, 2019 (153)
159 KHV_HUMAN_GENOMES ss3814448068 Jul 13, 2019 (153)
160 EVA ss3824603260 Apr 26, 2020 (154)
161 EVA ss3825527377 Apr 26, 2020 (154)
162 EVA ss3825542817 Apr 26, 2020 (154)
163 EVA ss3825795338 Apr 26, 2020 (154)
164 EVA ss3832548482 Apr 26, 2020 (154)
165 EVA ss3839825141 Apr 26, 2020 (154)
166 EVA ss3845302521 Apr 26, 2020 (154)
167 HGDP ss3847414251 Apr 26, 2020 (154)
168 SGDP_PRJ ss3875910060 Apr 26, 2020 (154)
169 KRGDB ss3924155219 Apr 26, 2020 (154)
170 KOGIC ss3969444282 Apr 26, 2020 (154)
171 FSA-LAB ss3983999143 Apr 26, 2021 (155)
172 EVA ss3984648348 Apr 26, 2021 (155)
173 EVA ss3984648349 Apr 26, 2021 (155)
174 EVA ss3985526498 Apr 26, 2021 (155)
175 EVA ss3986519821 Apr 26, 2021 (155)
176 EVA ss4017530352 Apr 26, 2021 (155)
177 TOPMED ss4879424522 Apr 26, 2021 (155)
178 TOMMO_GENOMICS ss5201227254 Apr 26, 2021 (155)
179 EVA ss5236892714 Apr 26, 2021 (155)
180 1000Genomes NC_000011.9 - 27679916 Oct 12, 2018 (152)
181 The Avon Longitudinal Study of Parents and Children NC_000011.9 - 27679916 Oct 12, 2018 (152)
182 Chileans NC_000011.9 - 27679916 Apr 26, 2020 (154)
183 Genome-wide autozygosity in Daghestan NC_000011.8 - 27636492 Apr 26, 2020 (154)
184 Genetic variation in the Estonian population NC_000011.9 - 27679916 Oct 12, 2018 (152)
185 ExAC NC_000011.9 - 27679916 Oct 12, 2018 (152)
186 FINRISK NC_000011.9 - 27679916 Apr 26, 2020 (154)
187 The Danish reference pan genome NC_000011.9 - 27679916 Apr 26, 2020 (154)
188 gnomAD - Genomes NC_000011.10 - 27658369 Apr 26, 2021 (155)
189 gnomAD - Exomes NC_000011.9 - 27679916 Jul 13, 2019 (153)
190 Genome of the Netherlands Release 5 NC_000011.9 - 27679916 Apr 26, 2020 (154)
191 HGDP-CEPH-db Supplement 1 NC_000011.8 - 27636492 Apr 26, 2020 (154)
192 HapMap NC_000011.10 - 27658369 Apr 26, 2020 (154)
193 KOREAN population from KRGDB NC_000011.9 - 27679916 Apr 26, 2020 (154)
194 Korean Genome Project NC_000011.10 - 27658369 Apr 26, 2020 (154)
195 Medical Genome Project healthy controls from Spanish population NC_000011.9 - 27679916 Apr 26, 2020 (154)
196 Northern Sweden NC_000011.9 - 27679916 Jul 13, 2019 (153)
197 The PAGE Study NC_000011.10 - 27658369 Jul 13, 2019 (153)
198 Ancient Sardinia genome-wide 1240k capture data generation and analysis NC_000011.9 - 27679916 Apr 26, 2021 (155)
199 CNV burdens in cranial meningiomas

Submission ignored due to conflicting rows:
Row 197823 (NC_000011.9:27679915:C:T 361/772)
Row 197824 (NC_000011.9:27679915:C:T 368/784)

- Apr 26, 2021 (155)
200 CNV burdens in cranial meningiomas

Submission ignored due to conflicting rows:
Row 197823 (NC_000011.9:27679915:C:T 361/772)
Row 197824 (NC_000011.9:27679915:C:T 368/784)

- Apr 26, 2021 (155)
201 Qatari NC_000011.9 - 27679916 Apr 26, 2020 (154)
202 SGDP_PRJ NC_000011.9 - 27679916 Apr 26, 2020 (154)
203 Siberian NC_000011.9 - 27679916 Apr 26, 2020 (154)
204 8.3KJPN NC_000011.9 - 27679916 Apr 26, 2021 (155)
205 TopMed NC_000011.10 - 27658369 Apr 26, 2021 (155)
206 UK 10K study - Twins NC_000011.9 - 27679916 Oct 12, 2018 (152)
207 A Vietnamese Genetic Variation Database NC_000011.9 - 27679916 Jul 13, 2019 (153)
208 ALFA NC_000011.10 - 27658369 Apr 26, 2021 (155)
209 ClinVar RCV000019267.5 Apr 26, 2020 (154)
210 ClinVar RCV000155463.2 Oct 12, 2018 (152)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs3829232 Oct 08, 2002 (108)
rs16917222 Oct 08, 2004 (123)
rs17855547 Mar 10, 2006 (126)
rs60760775 May 26, 2008 (130)
rs386602118 Jul 31, 2014 (136)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
74963, 92143, ss66120185, ss76112437, ss86044520, ss88519571, ss168106615, ss170723311, ss172543408, ss280939109, ss286344166, ss291208569, ss410940482, ss481228852, ss491641794, ss825549065, ss1397603702, ss1598022297, ss1713244242, ss2136776518, ss2635024532, ss3638964746, ss3639482955, ss3642897586, ss3847414251 NC_000011.8:27636491:C:T NC_000011.10:27658368:C:T (self)
53109772, 29503076, 72020, 20941949, 556161, 70280, 2500229, 8082902, 13161713, 31332613, 402677, 11321490, 752425, 13749450, 27927040, 7406419, 59196561, 29503076, 6555269, ss235499525, ss242143891, ss342321448, ss481252419, ss482238829, ss485409758, ss491015044, ss491448493, ss537344158, ss657957490, ss778938426, ss780896249, ss783150338, ss783582995, ss784106321, ss832409527, ss833044020, ss833634848, ss834400106, ss988346220, ss1067521512, ss1077605940, ss1340608745, ss1426582936, ss1575612641, ss1584073819, ss1626250508, ss1669244541, ss1690304714, ss1711286917, ss1752011944, ss1752011945, ss1917857738, ss1931707520, ss1946306031, ss1946306032, ss1959336449, ss1959336450, ss1967328479, ss2026601482, ss2094790360, ss2095021016, ss2154890065, ss2344365953, ss2627773729, ss2632817982, ss2632817983, ss2632817984, ss2699167918, ss2710732189, ss2738870976, ss2748583287, ss2897700734, ss2984938208, ss2985583329, ss3007801784, ss3021320974, ss3021320975, ss3023066529, ss3349517651, ss3625598510, ss3626628211, ss3626628212, ss3630836302, ss3632980783, ss3633679710, ss3634447257, ss3634447258, ss3635371481, ss3636131800, ss3637122310, ss3637898466, ss3640154596, ss3640154597, ss3644558838, ss3644558839, ss3646423872, ss3651683878, ss3651683879, ss3653710073, ss3675203701, ss3738036625, ss3744082850, ss3744378325, ss3744748154, ss3744748155, ss3749096546, ss3772248191, ss3772248192, ss3824603260, ss3825527377, ss3825542817, ss3825795338, ss3832548482, ss3839825141, ss3875910060, ss3924155219, ss3983999143, ss3984648348, ss3984648349, ss3985526498, ss3986519821, ss4017530352, ss5201227254 NC_000011.9:27679915:C:T NC_000011.10:27658368:C:T (self)
RCV000019267.5, RCV000155463.2, 374847171, 578720, 25822283, 836355, 59625618, 94970178, 13625787798, ss244238900, ss263197788, ss2181188897, ss3027099325, ss3140205643, ss3649567984, ss3691459786, ss3725228031, ss3771614886, ss3814448068, ss3845302521, ss3969444282, ss4879424522, ss5236892714 NC_000011.10:27658368:C:T NC_000011.10:27658368:C:T (self)
ss16110854, ss19221857, ss19926147, ss20799529 NT_009237.16:26443855:C:T NC_000011.10:27658368:C:T (self)
ss76884466 NT_009237.17:26467156:C:T NC_000011.10:27658368:C:T (self)
ss7889, ss5015735, ss12586728, ss16257509, ss22886806, ss24149102, ss28509849, ss38790107, ss48423502, ss66654688, ss67448802, ss67800191, ss69313816, ss70861507, ss71448862, ss75492161, ss76872494, ss79218547, ss83347130, ss97463065, ss122526781, ss132391628, ss137760330, ss154356517, ss159532780, ss159722962, ss160769670, ss172111436, ss173991729, ss182258803, ss182258834, ss244304653, ss469415390 NT_009237.18:27619915:C:T NC_000011.10:27658368:C:T (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

553 citations for rs6265
PMID Title Author Year Journal
12140781 Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Sklar P et al. 2002 Molecular psychiatry
12161822 The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Neves-Pereira M et al. 2002 American journal of human genetics
12553913 The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Egan MF et al. 2003 Cell
12836135 Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Hall D et al. 2003 American journal of human genetics
12888803 Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Ribasés M et al. 2003 Molecular psychiatry
15115760 Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Ribasés M et al. 2004 Human molecular genetics
15337662 Linkage disequilibrium of the brain-derived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. Geller B et al. 2004 The American journal of psychiatry
15457498 Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Friedel S et al. 2005 American journal of medical genetics. Part B, Neuropsychiatric genetics
16005437 Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Schumacher J et al. 2005 Biological psychiatry
16152572 Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. Lohoff FW et al. 2005 American journal of medical genetics. Part B, Neuropsychiatric genetics
16172806 The role of G196A polymorphism in the brain-derived neurotrophic factor gene in the cause of Parkinson's disease: a meta-analysis. Zintzaras E et al. 2005 Journal of human genetics
16222333 Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder. Rybakowski JK et al. 2006 Molecular psychiatry
16344533 BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Karamohamed S et al. 2005 Neurology
16389585 The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study. Rosa A et al. 2006 American journal of medical genetics. Part B, Neuropsychiatric genetics
16497333 No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. Surtees PG et al. 2007 Journal of psychiatric research
16631352 No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population. Watanabe Y et al. 2006 Schizophrenia research
16741941 Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate. Kremeyer B et al. 2006 American journal of medical genetics. Part B, Neuropsychiatric genetics
16962786 Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease. Kishikawa S et al. 2006 Neurobiology of disease
17096834 No association between polymorphisms in the BDNF gene and age at onset in Huntington disease. Mai M et al. 2006 BMC medical genetics
17135278 Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Saccone SF et al. 2007 Human molecular genetics
17196936 Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis. Qian L et al. 2007 Biochemical and biophysical research communications
17212826 TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach. Cozza A et al. 2007 BMC genomics
17219016 No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD. Schimmelmann BG et al. 2007 Journal of neural transmission (Vienna, Austria
17293537 Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. Huang R et al. 2007 Journal of medical genetics
17417060 Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder. Kanazawa T et al. 2007 Psychiatric genetics
17483451 Gene-gene interaction associated with neural reward sensitivity. Yacubian J et al. 2007 Proceedings of the National Academy of Sciences of the United States of America
17503330 A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Lou XY et al. 2007 American journal of human genetics
17602759 Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis. Weinstock-Guttman B et al. 2007 Journal of neuroimmunology
17632285 The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Ribeiro L et al. 2007 Neuroreport
17653045 Candidate gene and locus analysis of myopia. Mutti DO et al. 2007 Molecular vision
17656372 Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor. Zivadinov R et al. 2007 Human molecular genetics
17657167 Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population. He XM et al. 2007 Neuropsychobiology
17894414 BDNF Val66Met variant and age of onset in schizophrenia. Chao HM et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
17918236 Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder. Lee J et al. 2007 American journal of medical genetics. Part B, Neuropsychiatric genetics
18205169 Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. Chen L et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
18478177 Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine. Marziniak M et al. 2008 Journal of neural transmission (Vienna, Austria
18534558 Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Li MD et al. 2008 Biological psychiatry
18565990 Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. Saccone SF et al. 2008 Bioinformatics (Oxford, England)
18600033 Association of polymorphism (Val66Met) of brain-derived neurotrophic factor with suicide attempts in depressed patients. Sarchiapone M et al. 2008 Neuropsychobiology
18698231 Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. Johnson AD et al. 2008 Pharmacogenetics and genomics
18704161 Genetic variation in an individual human exome. Ng PC et al. 2008 PLoS genetics
18776599 Susceptibility genes for gentamicin-induced vestibular dysfunction. Roth SM et al. 2008 Journal of vestibular research
18779388 Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. Kavvoura FK et al. 2008 American journal of epidemiology
18813964 Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Kauwe JS et al. 2009 Neurogenetics
18830724 Assessment of Alzheimer's disease case-control associations using family-based methods. Schjeide BM et al. 2009 Neurogenetics
18852698 Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Verhagen M et al. 2010 Molecular psychiatry
18957941 Genome-wide association scan for five major dimensions of personality. Terracciano A et al. 2010 Molecular psychiatry
19018231 Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder. Liu L et al. 2008 Psychiatric genetics
19018715 Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients. Dmitrzak-Weglarz M et al. 2008 Pharmacogenomics
19209189 Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI. Shugart YY et al. 2009 European journal of human genetics
19236730 Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response. Domschke K et al. 2010 The international journal of neuropsychopharmacology
19258022 Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Boettiger CA et al. 2009 Pharmacology, biochemistry, and behavior
19295238 Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families. Szczepankiewicz A et al. 2009 International archives of allergy and immunology
19330778 Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population. Xu J et al. 2010 American journal of medical genetics. Part B, Neuropsychiatric genetics
19336781 Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes. Lencz T et al. 2009 The British journal of psychiatry
19359258 Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project. Goodyer IM et al. 2010 International journal of epidemiology
19388013 BDNF, relative preference, and reward circuitry responses to emotional communication. Gasic GP et al. 2009 American journal of medical genetics. Part B, Neuropsychiatric genetics
19403460 Pharmacogenetics of antidepressant response: an update. Drago A et al. 2009 Human genomics
19412541 Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. Li G et al. 2009 PloS one
19414708 Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Licinio J et al. 2009 Archives of general psychiatry
19424874 Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population. Gong P et al. 2009 Journal of molecular neuroscience
19461660 No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population. Otowa T et al. 2009 Journal of human genetics
19478790 The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. Zhao J et al. 2009 Obesity (Silver Spring, Md.)
19530966 Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis. Sánchez-Romero MA et al. 2009 Pharmacogenomics
19582215 Association study between BDNF gene polymorphisms and autism by three-dimensional gel-based microarray. Cheng L et al. 2009 International journal of molecular sciences
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30954706 The brain-derived neurotrophic factor Val66Met genotype does not influence the grey or white matter structures underlying recognition memory. McKay NS et al. 2019 NeuroImage
30964066 Differences in brain-derived neurotrophic factor gene polymorphisms between acute ischemic stroke patients and healthy controls in the Han population of southwest China. Zhou J et al. 2019 Neural regeneration research
30981636 BDNF and NGF gene polymorphisms and urine BDNF-NGF levels in children with primary monosymptomatic nocturnal enuresis. Ece A et al. 2019 Journal of pediatric urology
30988377 Influence of childhood trauma and brain-derived neurotrophic factor Val66Met polymorphism on posttraumatic stress symptoms and cortical thickness. Jin MJ et al. 2019 Scientific reports
31004714 BDNF Val66Met genetic variation and its plasma level in patients with morbid obesity: A case-control study. Zamani M et al. 2019 Gene
31023072 Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms. Knisely MR et al. 2019 Biological research for nursing
31046037 Suicide ideation and attempts in obsessive-compulsive disorder. Breet E et al. 2019 Annals of clinical psychiatry
31105428 A Functional Polymorphism (rs6265, G&gt;A) of Brain-Derived Neurotrophic Factor Gene and Breast Cancer: An Association Study. Iqbal MUN et al. 2019 Breast cancer
31111219 Genetic endophenotypes for insomnia of major depressive disorder and treatment-induced insomnia. Badamasi IM et al. 2019 Journal of neural transmission (Vienna, Austria
31112471 The Influence of Hippocampal Dopamine D2 Receptors on Episodic Memory Is Modulated by <i>BDNF</i> and <i>KIBRA</i> Polymorphisms. Papenberg G et al. 2019 Journal of cognitive neuroscience
31127785 Dysregulation of BDNF in Prefrontal Cortex in Alzheimer's Disease. Aarons T et al. 2019 Journal of Alzheimer's disease
31129315 Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain. Chidambaran V et al. 2020 The journal of pain
31132388 Investigating the Contribution of NPSR1, IL-6 and BDNF Polymorphisms to Depressive and Anxiety Symptoms in Hemodialysis Patients. Alshogran OY et al. 2019 Progress in neuro-psychopharmacology & biological psychiatry
31134487 Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson's Disease: A Study from Eastern India. Pal P et al. 2019 Neuromolecular medicine
31142902 Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders. Cengiz M et al. 2019 Indian journal of psychiatry
31180700 BDNF association study with obsessive-compulsive disorder, its clinical characteristics, and response to fluvoxamine-treatment in Iranian patients. Abdolhosseinzadeh S et al. 2020 Experimental and clinical psychopharmacology
31291217 Is Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism Associated with Obsessive-Compulsive Disorder? A Meta-Analysis. Wang S et al. 2019 Psychiatria Danubina
31291230 Associations of Gene Variations in Neuropeptide Y and Brain Derived Neurotrophic Factor Genes with Posttraumatic Stress Disorder. Ferić Bojić E et al. 2019 Psychiatria Danubina
31292011 Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson's disease. D'Souza T et al. 2020 Acta neuropsychiatrica
31295515 Polymorphisms in the BDNF and BDNFOS genes are associated with hypothalamus-pituitary axis regulation in major depression. Hennings JM et al. 2019 Progress in neuro-psychopharmacology & biological psychiatry
31431610 Hippocampal volume change following ECT is mediated by rs699947 in the promotor region of VEGF. Van Den Bossche MJA et al. 2019 Translational psychiatry
31445421 Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis. Lodhi RJ et al. 2019 Psychiatry research
31465000 Brain-derived neurotrophic factor and schizophrenia. Di Carlo P et al. 2019 Psychiatric genetics
31502573 Association of <i>BDNF</i> rs6265 and <i>MC4R</i> rs17782313 with metabolic syndrome in Pakistanis. Rana S et al. 2019 Journal of biosciences
31504225 Interaction Between Physical Activity and Genes Related to Neurotrophin Signaling in Late-Life Cognitive Performance: The Cache County Study. Sanders CL et al. 2020 The journals of gerontology. Series A, Biological sciences and medical sciences
31552390 Placebo effects and the molecular biological components involved. Cai L et al. 2019 General psychiatry
31555452 <i>BDNF</i>, <i>COMT</i>, and <i>DRD2</i> polymorphisms and ability to return to work in adult patients with low- and high-grade glioma. Altshuler DB et al. 2019 Neuro-oncology practice
31611000 Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: A prospective inception cohort study in treatment-free patients. Ochi T et al. 2019 Journal of affective disorders
31721892 Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial. Brunoni AR et al. 2020 Revista brasileira de psiquiatria (Sao Paulo, Brazil
31728141 The Brain-Derived Neurotrophic Factor <i>(BDNF)</i> gene Val66Met (rs6265) polymorphism and stress among preclinical medical students in Malaysia. Al-Hatamleh MAI et al. 2019 Journal of Taibah University Medical Sciences
31744450 Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine. Abijo T et al. 2020 Current neuropharmacology
31787753 Meta-analytic method reveal a significant association of theBDNF Val66Met variant with smoking persistence based on a large samples. Zhao H et al. 2020 The pharmacogenomics journal
31787925 BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes. Giarratana AO et al. 2019 Frontiers in neurology
31839607 Is Peripheral BDNF Promoter Methylation a Preclinical Biomarker of Dementia? Fransquet PD et al. 2020 Journal of Alzheimer's disease
31934064 BDNF gene polymorphism and serum level correlate with liver function in patients with hepatitis B-induced cirrhosis. Shu HC et al. 2019 International journal of clinical and experimental pathology
32022467 Gene polymorphisms and motor levodopa-induced complications in Parkinson's disease. Michałowska M et al. 2020 Brain and behavior
32056765 Association between BDNF gene polymorphisms and attention deficit hyperactivity disorder in school-aged children in Wuhan, China. Luo L et al. 2020 Journal of affective disorders
32063579 Methylation of Brain Derived Neurotrophic Factor (BDNF) Val66Met CpG site is associated with early onset bipolar disorder. Nassan M et al. 2020 Journal of affective disorders
32066722 Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child. Qi R et al. 2020 Translational psychiatry
32069471 The Association of Parental Genetic, Lifestyle, and Social Determinants of Health with Offspring Overweight. Graham CAM et al. 2020 Lifestyle genomics
32077707 BDNF Val⁶⁶Met polymorphism to generalized anxiety disorder pathways: Indirect effects via attenuated parasympathetic stress-relaxation reactivity. Chang HA et al. 2020 Journal of abnormal psychology
32081932 The BDNF Val66Met polymorphism affects negative memory bias in civilian women with PTSD. Hori H et al. 2020 Scientific reports
32116853 Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients. Losenkov IS et al. 2020 Frontiers in psychiatry
32122803 Pharmacogenetic Implications for Antidepressant Pharmacotherapy in Late-Life Depression: A Systematic Review of the Literature for Response, Pharmacokinetics and Adverse Drug Reactions. Marshe VS et al. 2020 The American journal of geriatric psychiatry
32157595 The role of childhood adversities, FKBP5, BDNF, NRN1, and generalized self-efficacy in suicide attempts in alcohol-dependent patients. Berent D et al. 2020 Pharmacological reports
32295326 The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population. Kang SG et al. 2020 Psychiatry investigation
32351633 An Analysis of Five <i>TrkB</i> Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism. Suchanek-Raif R et al. 2020 Disease markers
32352830 Combined genetic influences on episodic memory decline in older adults without dementia. Laukka EJ et al. 2020 Neuropsychology
32490241 Negative association between left prefrontal GABA concentration and BDNF serum concentration in young adults. Müller ST et al. 2020 Heliyon
32562379 DNA Methylation and Brain-Derived Neurotrophic Factor Expression Account for Symptoms and Widespread Hyperalgesia in Patients With Chronic Fatigue Syndrome and Comorbid Fibromyalgia. Polli A et al. 2020 Arthritis & rheumatology (Hoboken, N.J.)
32569264 The genetic profile of elite youth soccer players and its association with power and speed depends on maturity status. Murtagh CF et al. 2020 PloS one
32576619 Effects of <i>TPH2</i> gene variation and childhood trauma on the clinical and circuit-level phenotype of functional movement disorders. Spagnolo PA et al. 2020 Journal of neurology, neurosurgery, and psychiatry
32696315 Associations of plasma brain-derived neurotrophic factor (BDNF) and Val66Met polymorphism (rs6265) with long-term cancer-related cognitive impairment in survivors of breast cancer. Yap NY et al. 2020 Breast cancer research and treatment
32726665 Association of circulating BDNF levels with BDNF rs6265 polymorphism in schizophrenia. Kumar PK et al. 2020 Behavioural brain research
32736598 Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia. da Silveira Alves CF et al. 2020 Advances in rheumatology (London, England)
32776402 Role of rs6265 BDNF polymorphisms and post-stroke dysphagia recovery-A prospective cohort study. Oh HM et al. 2021 Neurogastroenterology and motility
32819202 Association between genetic polymorphism and antidepressants in major depression: a network meta-analysis. Du D et al. 2020 Pharmacogenomics
32866209 Detection of epistasis between ACTN3 and SNAP-25 with an insight towards gymnastic aptitude identification. Płóciennik ŁA et al. 2020 PloS one
32891918 Working memory moderates the relation between the brain-derived neurotropic factor (BDNF) and psychotherapy outcome for depression. Bruijniks SJE et al. 2020 Journal of psychiatric research
32985495 Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression. Li W et al. 2020 Medical science monitor
32991522 Brain-derived neurotrophic factor Val66Met polymorphism affects cortical thickness of rostral anterior cingulate in patients with major depressive disorder. Shen Z et al. 2020 Neuroreport
33007373 Differential promoter methylation and G-712A polymorphism of brain-derived neurotrophic factor in post-traumatic stress disorder patients of Li and Han populations in Hainan province. Guo J et al. 2021 Gene
33017682 CREB1 and BDNF gene polymorphisms are associated with early treatment response to escitalopram in panic disorder. Yang J et al. 2021 Journal of affective disorders
33017888 Effects of BDNF Val66Met Polymorphism on White Matter Microalterations of the Corpus Callosum in Patients with Panic Disorder in Korean Populations. Kim HJ et al. 2020 Psychiatry investigation
33036942 Influence of the BDNF Val66Met polymorphism on weight loss after bariatric surgery: a 24-month follow-up. Peña E et al. 2021 Surgery for obesity and related diseases
33040669 Genetics of human startle reactivity: A systematic review to acquire targets for an anxiety endophenotype. Tomasi J et al. 2021 The world journal of biological psychiatry
33047489 Associations between brain-derived neurotrophic factor and cognitive impairment in panic disorder. Wang W et al. 2020 Brain and behavior
33050457 The BDNF rs6265 Polymorphism is a Modifier of Cardiomyocyte Contractility and Dilated Cardiomyopathy. Raucci FJ Jr et al. 2020 International journal of molecular sciences
33073590 BDNF (rs6265) Val &lt; Met polymorphism can buffer cognitive functions against post stroke CT/MRI pathological findings. Rezaei S et al. 2022 Applied neuropsychology. Adult
33096746 Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment. Thakran S et al. 2020 International journal of molecular sciences
33145279 Genetic polymorphisms in neuroendocrine disorder-related candidate genes associated with pre-pregnancy obesity in gestational diabetes mellitus patients by using a stratification approach. Lee KW et al. 2020 Annals of translational medicine
33182716 BDNF rs6265 Polymorphism and Its Methylation in Patients with Stroke Undergoing Rehabilitation. Santoro M et al. 2020 International journal of molecular sciences
33188920 The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats. Mercado NM et al. 2021 Neurobiology of disease
33215284 BDNF rs6265 Variant Alters Outcomes with Levodopa in Early-Stage Parkinson's Disease. Fischer DL et al. 2020 Neurotherapeutics
33262686 Genetic Polymorphism of <i>ADORA2A</i> Is Associated With the Risk of Epilepsy and Predisposition to Neurologic Comorbidity in Chinese Southern Children. Fan X et al. 2020 Frontiers in neuroscience
33369083 BDNF VAL66MET polymorphism and memory decline across the spectrum of Alzheimer's disease. Lim YY et al. 2021 Genes, brain, and behavior
33384622 BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications. Fu X et al. 2020 Frontiers in psychiatry
33405375 Association between BDNF rs6265 polymorphisms and postoperative cognitive dysfunction in Chinese Han Population. Xie S et al. 2020 Brain and behavior
33450468 The relationship between occupational stress, musculoskeletal disorders and the mental health of coal miners: The interaction between BDNF gene, TPH2 gene polymorphism and the environment. Li X et al. 2021 Journal of psychiatric research
33499851 Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study. Tajbakhsh A et al. 2021 BMC medical genomics
33578508 Lack of association between BDNF rs6265 polymorphism and risk of type 2 diabetes: A protocol for meta-analysis and trial sequential analysis. Xie XQ et al. 2021 Medicine
33637225 The BDNF Val<sup>66</sup>Met polymorphism regulates vulnerability to chronic stress and phantom perception. Vanneste S et al. 2021 Progress in brain research
33685039 The Mediating Effect of Psychological Distress on the Association between BDNF, 5-HTTLPR, and Tinnitus Severity. Jeong JE et al. 2021 Psychiatry investigation
Help

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

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Select flank length:

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post676+237644a