Name: rs4680
Published: April 9, 2021
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

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This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs4680

Current Build 155

Released April 9, 2021

Organism: Homo sapiens
Position: chr22:19963748 (GRCh38.p13) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: G>A
Variation Type: SNV Single Nucleotide Variation
Frequency: A=0.489085 (138095/282354, ALFA)
A=0.420394 (111274/264690, TOPMED)
A=0.461091 (114049/247346, GnomAD_exome) (+ 25 more)
A=0.440445 (61679/140038, GnomAD)
A=0.472746 (55317/117012, ExAC)
A=0.34951 (27472/78602, PAGE_STUDY)
A=0.31730 (5318/16760, 8.3KJPN)
A=0.3692 (1849/5008, 1000G)
G=0.4507 (2019/4480, Estonian)
G=0.4878 (1880/3854, ALSPAC)
G=0.4984 (1848/3708, TWINSUK)
A=0.3926 (1280/3260, PRJNA289433)
G=0.4993 (1471/2946, PharmGKB)
A=0.2850 (835/2930, KOREAN)
A=0.3781 (788/2084, HGDP_Stanford)
A=0.3513 (664/1890, HapMap)
A=0.2686 (492/1832, Korea1K)
G=0.483 (482/998, GoNL)
A=0.241 (183/760, PRJEB37584)
A=0.254 (156/614, Vietnamese)
G=0.462 (277/600, NorthernSweden)
A=0.436 (233/534, MGP)
G=0.349 (123/352, SGDP_PRJ)
G=0.459 (134/292, FINRISK)
G=0.458 (99/216, Qatari)
A=0.47 (40/86, Ancient Sardinia)
G=0.31 (13/42, Siberian)
G=0.28 (11/40, GENOME_DK)

Clinical Significance: Reported in ClinVar
Gene : Consequence: COMT : Missense Variant
MIR4761 : 2KB Upstream Variant
Publications: 791 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	282354	G=0.510915	A=0.489085
European	Sub	233224	G=0.491982	A=0.508018
African	Sub	11528	G=0.69240	A=0.30760
African Others	Sub	370	G=0.735	A=0.265
African American	Sub	11158	G=0.69098	A=0.30902
Asian	Sub	3820	G=0.7351	A=0.2649
East Asian	Sub	2420	G=0.7231	A=0.2769
Other Asian	Sub	1400	G=0.7557	A=0.2443
Latin American 1	Sub	976	G=0.571	A=0.429
Latin American 2	Sub	8888	G=0.5842	A=0.4158
South Asian	Sub	5060	G=0.5496	A=0.4504
Other	Sub	18858	G=0.54073	A=0.45927

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	G=0.579606	A=0.420394
gnomAD - Exomes	Global	Study-wide	247346	G=0.538909	A=0.461091
gnomAD - Exomes	European	Sub	131988	G=0.475430	A=0.524570
gnomAD - Exomes	Asian	Sub	48836	G=0.62306	A=0.37694
gnomAD - Exomes	American	Sub	34390	G=0.59520	A=0.40480
gnomAD - Exomes	African	Sub	16062	G=0.68920	A=0.31080
gnomAD - Exomes	Ashkenazi Jewish	Sub	10002	G=0.53889	A=0.46111
gnomAD - Exomes	Other	Sub	6068	G=0.5255	A=0.4745
gnomAD - Genomes	Global	Study-wide	140038	G=0.559555	A=0.440445
gnomAD - Genomes	European	Sub	75840	G=0.47466	A=0.52534
gnomAD - Genomes	African	Sub	41954	G=0.68883	A=0.31117
gnomAD - Genomes	American	Sub	13648	G=0.59137	A=0.40863
gnomAD - Genomes	Ashkenazi Jewish	Sub	3318	G=0.5524	A=0.4476
gnomAD - Genomes	East Asian	Sub	3128	G=0.7324	A=0.2676
gnomAD - Genomes	Other	Sub	2150	G=0.5893	A=0.4107
ExAC	Global	Study-wide	117012	G=0.527254	A=0.472746
ExAC	Europe	Sub	70538	G=0.46782	A=0.53218
ExAC	Asian	Sub	24544	G=0.60720	A=0.39280
ExAC	American	Sub	11212	G=0.59249	A=0.40751
ExAC	African	Sub	9850	G=0.6803	A=0.3197
ExAC	Other	Sub	868	G=0.517	A=0.483
The PAGE Study	Global	Study-wide	78602	G=0.65049	A=0.34951
The PAGE Study	AfricanAmerican	Sub	32444	G=0.68444	A=0.31556
The PAGE Study	Mexican	Sub	10808	G=0.59354	A=0.40646
The PAGE Study	Asian	Sub	8304	G=0.6856	A=0.3144
The PAGE Study	PuertoRican	Sub	7912	G=0.6030	A=0.3970
The PAGE Study	NativeHawaiian	Sub	4532	G=0.7321	A=0.2679
The PAGE Study	Cuban	Sub	4230	G=0.5929	A=0.4071
The PAGE Study	Dominican	Sub	3828	G=0.6196	A=0.3804
The PAGE Study	CentralAmerican	Sub	2450	G=0.5878	A=0.4122
The PAGE Study	SouthAmerican	Sub	1980	G=0.6045	A=0.3955
The PAGE Study	NativeAmerican	Sub	1258	G=0.5676	A=0.4324
The PAGE Study	SouthAsian	Sub	856	G=0.579	A=0.421
8.3KJPN	JAPANESE	Study-wide	16760	G=0.68270	A=0.31730
1000Genomes	Global	Study-wide	5008	G=0.6308	A=0.3692
1000Genomes	African	Sub	1322	G=0.7194	A=0.2806
1000Genomes	East Asian	Sub	1008	G=0.7202	A=0.2798
1000Genomes	Europe	Sub	1006	G=0.5000	A=0.5000
1000Genomes	South Asian	Sub	978	G=0.559	A=0.441
1000Genomes	American	Sub	694	G=0.622	A=0.378
Genetic variation in the Estonian population	Estonian	Study-wide	4480	G=0.4507	A=0.5493
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.4878	A=0.5122
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.4984	A=0.5016
MxGDAR/Encodat-PGx	Global	Study-wide	3260	G=0.6074	A=0.3926
MxGDAR/Encodat-PGx	MxGDAR	Sub	3260	G=0.6074	A=0.3926
PharmGKB Aggregated	Global	Study-wide	2946	G=0.4993	A=0.5007
PharmGKB Aggregated	PA156007059	Sub	2352	G=0.4613	A=0.5387
PharmGKB Aggregated	PA150018199	Sub	354	G=0.658	A=0.342
PharmGKB Aggregated	PA137869186	Sub	240	G=0.637	A=0.362
KOREAN population from KRGDB	KOREAN	Study-wide	2930	G=0.7150	A=0.2850
HGDP-CEPH-db Supplement 1	Global	Study-wide	2084	G=0.6219	A=0.3781
HGDP-CEPH-db Supplement 1	Est_Asia	Sub	470	G=0.743	A=0.257
HGDP-CEPH-db Supplement 1	Central_South_Asia	Sub	414	G=0.527	A=0.473
HGDP-CEPH-db Supplement 1	Middle_Est	Sub	350	G=0.523	A=0.477
HGDP-CEPH-db Supplement 1	Europe	Sub	320	G=0.512	A=0.487
HGDP-CEPH-db Supplement 1	Africa	Sub	242	G=0.744	A=0.256
HGDP-CEPH-db Supplement 1	America	Sub	216	G=0.713	A=0.287
HGDP-CEPH-db Supplement 1	Oceania	Sub	72	G=0.67	A=0.33
HapMap	Global	Study-wide	1890	G=0.6487	A=0.3513
HapMap	American	Sub	770	G=0.613	A=0.387
HapMap	African	Sub	690	G=0.701	A=0.299
HapMap	Asian	Sub	254	G=0.689	A=0.311
HapMap	Europe	Sub	176	G=0.540	A=0.460
Korean Genome Project	KOREAN	Study-wide	1832	G=0.7314	A=0.2686
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	G=0.483	A=0.517
CNV burdens in cranial meningiomas	Global	Study-wide	760	G=0.759	A=0.241
CNV burdens in cranial meningiomas	CRM	Sub	760	G=0.759	A=0.241
A Vietnamese Genetic Variation Database	Global	Study-wide	614	G=0.746	A=0.254
Northern Sweden	ACPOP	Study-wide	600	G=0.462	A=0.538
Medical Genome Project healthy controls from Spanish population	Spanish controls	Study-wide	534	G=0.564	A=0.436
SGDP_PRJ	Global	Study-wide	352	G=0.349	A=0.651
FINRISK	Finnish from FINRISK project	Study-wide	292	G=0.459	A=0.541
Qatari	Global	Study-wide	216	G=0.458	A=0.542
Ancient Sardinia genome-wide 1240k capture data generation and analysis	Global	Study-wide	86	G=0.53	A=0.47
Siberian	Global	Study-wide	42	G=0.31	A=0.69
The Danish reference pan genome	Danish	Study-wide	40	G=0.28	A=0.72

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p13 chr 22	NC_000022.11:g.19963748G>A
GRCh37.p13 chr 22	NC_000022.10:g.19951271G>A
COMT RefSeqGene (LRG_1010)	NG_011526.1:g.27009G>A

Gene: COMT, catechol-O-methyltransferase (plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
COMT transcript variant 3	NM_001135162.2:c.472G>A	V [GTG] > M [ATG]	Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT	NP_001128634.1:p.Val158Met	V (Val) > M (Met)	Missense Variant
COMT transcript variant 2	NM_001135161.2:c.472G>A	V [GTG] > M [ATG]	Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT	NP_001128633.1:p.Val158Met	V (Val) > M (Met)	Missense Variant
COMT transcript variant 5	NM_001362828.2:c.472G>A	V [GTG] > M [ATG]	Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT	NP_001349757.1:p.Val158Met	V (Val) > M (Met)	Missense Variant
COMT transcript variant 4	NM_007310.3:c.322G>A	V [GTG] > M [ATG]	Coding Sequence Variant
catechol O-methyltransferase isoform S-COMT	NP_009294.1:p.Val108Met	V (Val) > M (Met)	Missense Variant
COMT transcript variant 1	NM_000754.4:c.472G>A	V [GTG] > M [ATG]	Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT	NP_000745.1:p.Val158Met	V (Val) > M (Met)	Missense Variant

Gene: MIR4761, microRNA 4761 (plus strand) : 2KB Upstream Variant

Molecule type	Change	Amino acid[Codon]	SO Term
MIR4761 transcript	NR_039918.1:n.	N/A	Upstream Transcript Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: A (allele ID: 32630 )

ClinVar Accession	Disease Names	Clinical Significance
RCV000019156.4	CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM	Benign
RCV000211145.1	nicotine response - Efficacy	Drug-Response
RCV000244083.1	not specified	Benign
RCV000786523.1	tramadol response - Dosage, Efficacy	Drug-Response
RCV000786728.1	methadone response - Dosage, Efficacy	Drug-Response
RCV000786729.1	morphine response - Dosage, Efficacy	Drug-Response
RCV000786730.1	opioids response - Dosage, Efficacy	Drug-Response
RCV000786731.1	oxycodone response - Dosage, Efficacy	Drug-Response
RCV000786732.1	remifentanil response - Dosage, Efficacy	Drug-Response
RCV000786733.1	sufentanil response - Dosage, Efficacy	Drug-Response
RCV001028880.1	Tramadol response	Drug-Response

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	G=	A
GRCh38.p13 chr 22	NC_000022.11:g.19963748=	NC_000022.11:g.19963748G>A
GRCh37.p13 chr 22	NC_000022.10:g.19951271=	NC_000022.10:g.19951271G>A
COMT RefSeqGene (LRG_1010)	NG_011526.1:g.27009=	NG_011526.1:g.27009G>A
COMT transcript variant 1	NM_000754.4:c.472=	NM_000754.4:c.472G>A
COMT transcript variant 1	NM_000754.3:c.472=	NM_000754.3:c.472G>A
COMT transcript variant 4	NM_007310.3:c.322=	NM_007310.3:c.322G>A
COMT transcript variant 4	NM_007310.2:c.322=	NM_007310.2:c.322G>A
COMT transcript variant 5	NM_001362828.2:c.472=	NM_001362828.2:c.472G>A
COMT transcript variant 5	NM_001362828.1:c.472=	NM_001362828.1:c.472G>A
COMT transcript variant 2	NM_001135161.2:c.472=	NM_001135161.2:c.472G>A
COMT transcript variant 2	NM_001135161.1:c.472=	NM_001135161.1:c.472G>A
COMT transcript variant 3	NM_001135162.2:c.472=	NM_001135162.2:c.472G>A
COMT transcript variant 3	NM_001135162.1:c.472=	NM_001135162.1:c.472G>A
catechol O-methyltransferase isoform MB-COMT	NP_000745.1:p.Val158=	NP_000745.1:p.Val158Met
catechol O-methyltransferase isoform S-COMT	NP_009294.1:p.Val108=	NP_009294.1:p.Val108Met
catechol O-methyltransferase isoform MB-COMT	NP_001349757.1:p.Val158=	NP_001349757.1:p.Val158Met
catechol O-methyltransferase isoform MB-COMT	NP_001128633.1:p.Val158=	NP_001128633.1:p.Val158Met
catechol O-methyltransferase isoform MB-COMT	NP_001128634.1:p.Val158=	NP_001128634.1:p.Val158Met

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

195 SubSNP, 28 Frequency, 11 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	DEBNICK	ss5363	Sep 19, 2000 (52)
2	CGAP-GAI	ss10902	Sep 19, 2000 (52)
3	KWOK	ss232568	Jul 12, 2000 (109)
4	SC	ss458935	Jul 12, 2000 (109)
5	SC_JCM	ss593353	Jul 16, 2000 (109)
6	UWGC	ss869771	Oct 04, 2000 (109)
7	KWOK	ss1058120	Oct 04, 2000 (109)
8	LEE	ss1525135	Oct 13, 2000 (102)
9	KWOK	ss1750406	Oct 18, 2000 (109)
10	HGBASE	ss2419858	Nov 14, 2000 (109)
11	AFFX	ss2982266	Jun 15, 2001 (102)
12	LEE	ss4394550	May 29, 2002 (109)
13	LEE	ss4415842	May 29, 2002 (108)
14	YUSUKE	ss4933092	Aug 28, 2002 (109)
15	SNP500CANCER	ss5586357	Mar 31, 2003 (113)
16	RIKENSNPRC	ss6311517	Feb 20, 2003 (111)
17	KIDDLAB	ss6312623	Feb 20, 2003 (111)
18	HG_BONN_CNS_SNPS	ss12586777	Aug 26, 2003 (117)
19	EGP_SNPS	ss12673767	Dec 05, 2003 (119)
20	CGAP-GAI	ss16240705	Feb 28, 2004 (126)
21	SSAHASNP	ss21854500	Apr 05, 2004 (121)
22	IMCJ-GDT	ss22886949	Apr 05, 2004 (121)
23	PERLEGEN	ss24702135	Sep 20, 2004 (123)
24	MGC_GENOME_DIFF	ss28503610	Sep 24, 2004 (126)
25	MGC_GENOME_DIFF	ss28504308	Sep 24, 2004 (126)
26	ABI	ss35031502	May 24, 2005 (125)
27	ABI	ss41527572	Mar 11, 2006 (126)
28	APPLERA_GI	ss48429990	Mar 11, 2006 (126)
29	ILLUMINA	ss65728351	Oct 15, 2006 (127)
30	KRIBB_YJKIM	ss65824277	Nov 30, 2006 (127)
31	ILLUMINA	ss66561034	Nov 30, 2006 (127)
32	EGP_SNPS	ss66862091	Nov 30, 2006 (127)
33	ILLUMINA	ss67358029	Nov 30, 2006 (127)
34	ILLUMINA	ss67746210	Nov 30, 2006 (127)
35	PERLEGEN	ss69277073	May 17, 2007 (127)
36	PHARMGKB_PPII	ss69367705	May 17, 2007 (127)
37	ILLUMINA	ss70815561	May 24, 2008 (130)
38	ILLUMINA	ss71396394	May 17, 2007 (127)
39	ILLUMINA	ss75741500	Dec 07, 2007 (129)
40	AFFY	ss76724792	Dec 07, 2007 (129)
41	SI_EXO	ss76883807	Dec 07, 2007 (129)
42	ILLUMINA	ss79189355	Dec 14, 2007 (130)
43	KRIBB_YJKIM	ss83346610	Dec 14, 2007 (130)
44	PHARMGKB_AB_DME	ss84156116	Dec 14, 2007 (130)
45	BCMHGSC_JDW	ss91877550	Mar 24, 2008 (129)
46	HUMANGENOME_JCVI	ss96092645	Feb 04, 2009 (130)
47	SHGC	ss99307578	Feb 04, 2009 (130)
48	PHARMGKB_PPII	ss105109907	Feb 04, 2009 (130)
49	1000GENOMES	ss112551473	Jan 25, 2009 (130)
50	1000GENOMES	ss114036054	Jan 25, 2009 (130)
51	ILLUMINA-UK	ss117362075	Feb 14, 2009 (130)
52	ILLUMINA	ss122352974	Dec 01, 2009 (131)
53	ENSEMBL	ss138335200	Dec 01, 2009 (131)
54	ENSEMBL	ss143168685	Dec 01, 2009 (131)
55	ILLUMINA	ss154307142	Dec 01, 2009 (131)
56	GMI	ss157034606	Dec 01, 2009 (131)
57	ILLUMINA	ss159483938	Dec 01, 2009 (131)
58	SEATTLESEQ	ss159743879	Dec 01, 2009 (131)
59	ILLUMINA	ss160697633	Dec 01, 2009 (131)
60	COMPLETE_GENOMICS	ss168891628	Jul 04, 2010 (132)
61	OMICIA	ss169700809	Aug 28, 2012 (137)
62	COMPLETE_GENOMICS	ss171832778	Jul 04, 2010 (132)
63	ILLUMINA	ss171858824	Jul 04, 2010 (132)
64	ILLUMINA	ss173777592	Jul 04, 2010 (132)
65	BUSHMAN	ss204050448	Jul 04, 2010 (132)
66	BCM-HGSC-SUB	ss208830194	Jul 04, 2010 (132)
67	1000GENOMES	ss228618146	Jul 14, 2010 (132)
68	1000GENOMES	ss238022303	Jul 15, 2010 (132)
69	1000GENOMES	ss244151662	Jul 15, 2010 (132)
70	ILLUMINA	ss244300758	Jul 04, 2010 (132)
71	OMIM-CURATED-RECORDS	ss275514028	Nov 22, 2010 (133)
72	GMI	ss283587220	May 04, 2012 (137)
73	GMI	ss287550246	Apr 25, 2013 (138)
74	PJP	ss292736320	May 09, 2011 (134)
75	NHLBI-ESP	ss342536620	May 09, 2011 (134)
76	ILLUMINA	ss410934884	Sep 17, 2011 (135)
77	ILLUMINA	ss481001618	May 04, 2012 (137)
78	ILLUMINA	ss481022354	May 04, 2012 (137)
79	ILLUMINA	ss482004819	Sep 08, 2015 (146)
80	ILLUMINA	ss485295756	May 04, 2012 (137)
81	1000GENOMES	ss491188318	May 04, 2012 (137)
82	EXOME_CHIP	ss491568471	May 04, 2012 (137)
83	CLINSEQ_SNP	ss491819536	May 04, 2012 (137)
84	ILLUMINA	ss537257559	Sep 08, 2015 (146)
85	TISHKOFF	ss566560789	Apr 25, 2013 (138)
86	SSMP	ss662483744	Apr 25, 2013 (138)
87	ILLUMINA	ss778542157	Sep 08, 2015 (146)
88	ILLUMINA	ss780760189	Sep 08, 2015 (146)
89	ILLUMINA	ss783093748	Sep 08, 2015 (146)
90	ILLUMINA	ss783439072	Sep 08, 2015 (146)
91	ILLUMINA	ss784051102	Sep 08, 2015 (146)
92	ILLUMINA	ss825519873	Apr 01, 2015 (144)
93	ILLUMINA	ss832352251	Sep 08, 2015 (146)
94	ILLUMINA	ss832995358	Jul 13, 2019 (153)
95	ILLUMINA	ss833998797	Sep 08, 2015 (146)
96	JMKIDD_LAB	ss974512061	Aug 21, 2014 (142)
97	EVA-GONL	ss995222796	Aug 21, 2014 (142)
98	JMKIDD_LAB	ss1067603859	Aug 21, 2014 (142)
99	JMKIDD_LAB	ss1082570467	Aug 21, 2014 (142)
100	1000GENOMES	ss1366683122	Aug 21, 2014 (142)
101	DDI	ss1429219785	Apr 01, 2015 (144)
102	EVA_GENOME_DK	ss1579704267	Apr 01, 2015 (144)
103	EVA_FINRISK	ss1584126415	Apr 01, 2015 (144)
104	EVA_UK10K_ALSPAC	ss1639753950	Apr 01, 2015 (144)
105	EVA_UK10K_TWINSUK	ss1682747983	Apr 01, 2015 (144)
106	EVA_EXAC	ss1694228953	Apr 01, 2015 (144)
107	EVA_MGP	ss1711560479	Apr 01, 2015 (144)
108	EVA_SVP	ss1713731247	Apr 01, 2015 (144)
109	ILLUMINA	ss1752413977	Sep 08, 2015 (146)
110	ILLUMINA	ss1752413978	Sep 08, 2015 (146)
111	YSAMUELS	ss1849931081	Feb 12, 2016 (147)
112	ILLUMINA	ss1917953438	Feb 12, 2016 (147)
113	WEILL_CORNELL_DGM	ss1938784399	Feb 12, 2016 (147)
114	ILLUMINA	ss1946577642	Feb 12, 2016 (147)
115	ILLUMINA	ss1959965712	Feb 12, 2016 (147)
116	GENOMED	ss1969246877	Jul 19, 2016 (147)
117	JJLAB	ss2030165213	Sep 14, 2016 (149)
118	USC_VALOUEV	ss2158775171	Dec 20, 2016 (150)
119	HUMAN_LONGEVITY	ss2246457027	Dec 20, 2016 (150)
120	TOPMED	ss2413283895	Dec 20, 2016 (150)
121	SYSTEMSBIOZJU	ss2629580757	Nov 08, 2017 (151)
122	ILLUMINA	ss2633862775	Nov 08, 2017 (151)
123	ILLUMINA	ss2633862776	Nov 08, 2017 (151)
124	ILLUMINA	ss2635110818	Nov 08, 2017 (151)
125	GRF	ss2704518125	Nov 08, 2017 (151)
126	GNOMAD	ss2744960035	Nov 08, 2017 (151)
127	GNOMAD	ss2750498451	Nov 08, 2017 (151)
128	GNOMAD	ss2972986300	Nov 08, 2017 (151)
129	AFFY	ss2985233274	Nov 08, 2017 (151)
130	AFFY	ss2985850713	Nov 08, 2017 (151)
131	SWEGEN	ss3019086373	Nov 08, 2017 (151)
132	ILLUMINA	ss3022171896	Nov 08, 2017 (151)
133	EVA_SAMSUNG_MC	ss3023073334	Nov 08, 2017 (151)
134	BIOINF_KMB_FNS_UNIBA	ss3028920322	Nov 08, 2017 (151)
135	CSHL	ss3352776493	Nov 08, 2017 (151)
136	TOPMED	ss3374061092	Nov 08, 2017 (151)
137	ILLUMINA	ss3628506015	Oct 12, 2018 (152)
138	ILLUMINA	ss3628506016	Oct 12, 2018 (152)
139	ILLUMINA	ss3631815167	Oct 12, 2018 (152)
140	ILLUMINA	ss3633268864	Oct 12, 2018 (152)
141	ILLUMINA	ss3633984254	Oct 12, 2018 (152)
142	ILLUMINA	ss3634860950	Oct 12, 2018 (152)
143	ILLUMINA	ss3634860951	Oct 12, 2018 (152)
144	ILLUMINA	ss3635668891	Oct 12, 2018 (152)
145	ILLUMINA	ss3636556582	Oct 12, 2018 (152)
146	ILLUMINA	ss3637421084	Oct 12, 2018 (152)
147	ILLUMINA	ss3638374444	Oct 12, 2018 (152)
148	ILLUMINA	ss3639191045	Oct 12, 2018 (152)
149	ILLUMINA	ss3639611681	Oct 12, 2018 (152)
150	ILLUMINA	ss3640568251	Oct 12, 2018 (152)
151	ILLUMINA	ss3640568252	Oct 12, 2018 (152)
152	ILLUMINA	ss3643334852	Oct 12, 2018 (152)
153	ILLUMINA	ss3644796332	Oct 12, 2018 (152)
154	OMUKHERJEE_ADBS	ss3646561243	Oct 12, 2018 (152)
155	URBANLAB	ss3651151884	Oct 12, 2018 (152)
156	ILLUMINA	ss3652633448	Oct 12, 2018 (152)
157	ILLUMINA	ss3654001338	Oct 12, 2018 (152)
158	EGCUT_WGS	ss3685618877	Jul 13, 2019 (153)
159	EVA_DECODE	ss3707954959	Jul 13, 2019 (153)
160	ILLUMINA	ss3725957492	Jul 13, 2019 (153)
161	ACPOP	ss3743823282	Jul 13, 2019 (153)
162	ILLUMINA	ss3744500496	Jul 13, 2019 (153)
163	ILLUMINA	ss3745160781	Jul 13, 2019 (153)
164	ILLUMINA	ss3745160782	Jul 13, 2019 (153)
165	EVA	ss3759230925	Jul 13, 2019 (153)
166	PAGE_CC	ss3772082274	Jul 13, 2019 (153)
167	ILLUMINA	ss3772656764	Jul 13, 2019 (153)
168	ILLUMINA	ss3772656765	Jul 13, 2019 (153)
169	PACBIO	ss3788793360	Jul 13, 2019 (153)
170	PACBIO	ss3793664452	Jul 13, 2019 (153)
171	PACBIO	ss3798550777	Jul 13, 2019 (153)
172	KHV_HUMAN_GENOMES	ss3822398809	Jul 13, 2019 (153)
173	EVA	ss3825423917	Apr 27, 2020 (154)
174	EVA	ss3825534088	Apr 27, 2020 (154)
175	EVA	ss3825548348	Apr 27, 2020 (154)
176	EVA	ss3825965512	Apr 27, 2020 (154)
177	EVA	ss3835927803	Apr 27, 2020 (154)
178	EVA	ss3841592403	Apr 27, 2020 (154)
179	EVA	ss3847107063	Apr 27, 2020 (154)
180	HGDP	ss3847684686	Apr 27, 2020 (154)
181	SGDP_PRJ	ss3890256798	Apr 27, 2020 (154)
182	KRGDB	ss3940640393	Apr 27, 2020 (154)
183	KOGIC	ss3983389655	Apr 27, 2020 (154)
184	FSA-LAB	ss3984229795	Apr 26, 2021 (155)
185	EVA	ss3984450654	Apr 26, 2021 (155)
186	EVA	ss3984758329	Apr 26, 2021 (155)
187	EVA	ss3985910179	Apr 26, 2021 (155)
188	EVA	ss3986086722	Apr 26, 2021 (155)
189	EVA	ss3986853417	Apr 26, 2021 (155)
190	EVA	ss4017873655	Apr 26, 2021 (155)
191	TOPMED	ss5105107985	Apr 26, 2021 (155)
192	TOMMO_GENOMICS	ss5232040561	Apr 26, 2021 (155)
193	EVA	ss5236988677	Apr 26, 2021 (155)
194	EVA	ss5237254842	Apr 26, 2021 (155)
195	EVA	ss5237615144	Apr 26, 2021 (155)
196	1000Genomes	NC_000022.10 - 19951271	Oct 12, 2018 (152)
197	The Avon Longitudinal Study of Parents and Children	NC_000022.10 - 19951271	Oct 12, 2018 (152)
198	Genetic variation in the Estonian population	NC_000022.10 - 19951271	Oct 12, 2018 (152)
199	ExAC	NC_000022.10 - 19951271	Oct 12, 2018 (152)
200	FINRISK	NC_000022.10 - 19951271	Apr 27, 2020 (154)
201	The Danish reference pan genome	NC_000022.10 - 19951271	Apr 27, 2020 (154)
202	gnomAD - Genomes	NC_000022.11 - 19963748	Apr 26, 2021 (155)
203	gnomAD - Exomes	NC_000022.10 - 19951271	Jul 13, 2019 (153)
204	Genome of the Netherlands Release 5	NC_000022.10 - 19951271	Apr 27, 2020 (154)
205	HGDP-CEPH-db Supplement 1	NC_000022.9 - 18331271	Apr 27, 2020 (154)
206	HapMap	NC_000022.11 - 19963748	Apr 27, 2020 (154)
207	KOREAN population from KRGDB	NC_000022.10 - 19951271	Apr 27, 2020 (154)
208	Korean Genome Project	NC_000022.11 - 19963748	Apr 27, 2020 (154)
209	Medical Genome Project healthy controls from Spanish population	NC_000022.10 - 19951271	Apr 27, 2020 (154)
210	Northern Sweden	NC_000022.10 - 19951271	Jul 13, 2019 (153)
211	The PAGE Study	NC_000022.11 - 19963748	Jul 13, 2019 (153)
212	Ancient Sardinia genome-wide 1240k capture data generation and analysis	NC_000022.10 - 19951271	Apr 26, 2021 (155)
213	CNV burdens in cranial meningiomas	NC_000022.10 - 19951271	Apr 26, 2021 (155)
214	MxGDAR/Encodat-PGx	NC_000022.10 - 19951271	Apr 26, 2021 (155)
215	PharmGKB Aggregated	NC_000022.11 - 19963748	Apr 27, 2020 (154)
216	Qatari	NC_000022.10 - 19951271	Apr 27, 2020 (154)
217	SGDP_PRJ	NC_000022.10 - 19951271	Apr 27, 2020 (154)
218	Siberian	NC_000022.10 - 19951271	Apr 27, 2020 (154)
219	8.3KJPN	NC_000022.10 - 19951271	Apr 26, 2021 (155)
220	TopMed	NC_000022.11 - 19963748	Apr 26, 2021 (155)
221	UK 10K study - Twins	NC_000022.10 - 19951271	Oct 12, 2018 (152)
222	A Vietnamese Genetic Variation Database	NC_000022.10 - 19951271	Jul 13, 2019 (153)
223	ALFA	NC_000022.11 - 19963748	Apr 26, 2021 (155)
224	ClinVar	RCV000019156.4	Oct 12, 2018 (152)
225	ClinVar	RCV000211145.1	Oct 12, 2018 (152)
226	ClinVar	RCV000244083.1	Oct 12, 2018 (152)
227	ClinVar	RCV000786523.1	Jul 13, 2019 (153)
228	ClinVar	RCV000786728.1	Jul 13, 2019 (153)
229	ClinVar	RCV000786729.1	Jul 13, 2019 (153)
230	ClinVar	RCV000786730.1	Jul 13, 2019 (153)
231	ClinVar	RCV000786731.1	Jul 13, 2019 (153)
232	ClinVar	RCV000786732.1	Jul 13, 2019 (153)
233	ClinVar	RCV000786733.1	Jul 13, 2019 (153)
234	ClinVar	RCV001028880.1	Apr 27, 2020 (154)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs165688	Nov 14, 2002 (109)
rs1131157	Jan 04, 2002 (102)
rs2070104	Jan 04, 2002 (102)
rs3177905	Jul 03, 2002 (106)
rs3190784	Oct 08, 2002 (108)
rs3747070	Oct 08, 2002 (108)
rs11544671	Mar 11, 2006 (126)
rs17295216	Mar 11, 2006 (126)
rs17349704	Mar 11, 2006 (126)
rs17818178	Oct 07, 2004 (123)
rs17849308	Mar 11, 2006 (126)
rs17850006	Mar 11, 2006 (126)
rs58002978	May 24, 2008 (130)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss3639191045, ss3639611681	NC_000022.8:18325824:G:A	NC_000022.11:19963747:G:A	(self)
362578, ss91877550, ss112551473, ss114036054, ss117362075, ss168891628, ss171832778, ss204050448, ss208830194, ss283587220, ss287550246, ss292736320, ss481001618, ss491819536, ss825519873, ss1713731247, ss2635110818, ss3643334852, ss3847684686	NC_000022.9:18331270:G:A	NC_000022.11:19963747:G:A	(self)
80217552, 44382019, 31357125, 5801172, 122876, 5869206, 14289515, 19773905, 47817787, 676239, 17108147, 1136106, 307910, 3655, 20826321, 42273778, 11291525, 90009868, 44382019, 9792535, ss228618146, ss238022303, ss244151662, ss342536620, ss481022354, ss482004819, ss485295756, ss491188318, ss491568471, ss537257559, ss566560789, ss662483744, ss778542157, ss780760189, ss783093748, ss783439072, ss784051102, ss832352251, ss832995358, ss833998797, ss974512061, ss995222796, ss1067603859, ss1082570467, ss1366683122, ss1429219785, ss1579704267, ss1584126415, ss1639753950, ss1682747983, ss1694228953, ss1711560479, ss1752413977, ss1752413978, ss1849931081, ss1917953438, ss1938784399, ss1946577642, ss1959965712, ss1969246877, ss2030165213, ss2158775171, ss2413283895, ss2629580757, ss2633862775, ss2633862776, ss2704518125, ss2744960035, ss2750498451, ss2972986300, ss2985233274, ss2985850713, ss3019086373, ss3022171896, ss3023073334, ss3352776493, ss3628506015, ss3628506016, ss3631815167, ss3633268864, ss3633984254, ss3634860950, ss3634860951, ss3635668891, ss3636556582, ss3637421084, ss3638374444, ss3640568251, ss3640568252, ss3644796332, ss3646561243, ss3652633448, ss3654001338, ss3685618877, ss3743823282, ss3744500496, ss3745160781, ss3745160782, ss3759230925, ss3772656764, ss3772656765, ss3788793360, ss3793664452, ss3798550777, ss3825423917, ss3825534088, ss3825548348, ss3825965512, ss3835927803, ss3841592403, ss3890256798, ss3940640393, ss3984229795, ss3984450654, ss3984758329, ss3985910179, ss3986086722, ss3986853417, ss4017873655, ss5232040561, ss5237615144	NC_000022.10:19951270:G:A	NC_000022.11:19963747:G:A	(self)
RCV000019156.4, RCV000211145.1, RCV000244083.1, RCV000786523.1, RCV000786728.1, RCV000786729.1, RCV000786730.1, RCV000786731.1, RCV000786732.1, RCV000786733.1, RCV001028880.1, 566543865, 2227945, 39767656, 1303743, 7572, 237443423, 380216932, 5950756585, ss169700809, ss275514028, ss2246457027, ss3028920322, ss3374061092, ss3651151884, ss3707954959, ss3725957492, ss3772082274, ss3822398809, ss3847107063, ss3983389655, ss5105107985, ss5236988677, ss5237254842	NC_000022.11:19963747:G:A	NC_000022.11:19963747:G:A	(self)
ss5363, ss10902, ss232568, ss458935, ss593353, ss869771, ss1058120, ss1525135, ss1750406, ss2419858, ss2982266, ss4394550, ss4415842, ss4933092, ss5586357, ss6311517, ss6312623, ss12586777, ss12673767, ss16240705, ss21854500, ss22886949, ss24702135, ss28503610, ss28504308, ss35031502, ss41527572, ss48429990, ss65728351, ss65824277, ss66561034, ss66862091, ss67358029, ss67746210, ss69277073, ss69367705, ss70815561, ss71396394, ss75741500, ss76724792, ss76883807, ss79189355, ss83346610, ss84156116, ss96092645, ss99307578, ss105109907, ss122352974, ss138335200, ss143168685, ss154307142, ss157034606, ss159483938, ss159743879, ss160697633, ss171858824, ss173777592, ss244300758, ss410934884	NT_011519.10:3103420:G:A	NC_000022.11:19963747:G:A	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

791 citations for rs4680

PMID	Title	Author	Year	Journal
848488	Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.	Weinshilboum RM et al.	1977	American journal of human genetics
7304673	Genetics of red cell COMT activity: analysis of thermal stability and family data.	Spielman RS et al.	1981	American journal of medical genetics
7585135	The psychobiological regulation of social cooperation.	Cloninger CR et al.	1995	Nature medicine
8807664	Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.	Lachman HM et al.	1996	Pharmacogenetics
8886163	Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome.	Lachman HM et al.	1996	American journal of medical genetics
8941353	No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferase.	Hoda F et al.	1996	Biochemical and biophysical research communications
9110364	Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland.	Syvänen AC et al.	1997	Pharmacogenetics
10395222	Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism.	Tiihonen J et al.	1999	Molecular psychiatry
10459407	Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.	Palmatier MA et al.	1999	Biological psychiatry
11171904	The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese.	Wu RM et al.	2001	Neurology
11381111	Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.	Egan MF et al.	2001	Proceedings of the National Academy of Sciences of the United States of America
11502905	Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism.	Graf WD et al.	2001	Neurology
11772685	Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder.	Rotondo A et al.	2002	The American journal of psychiatry
11925305	A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.	Malhotra AK et al.	2002	The American journal of psychiatry
12192614	Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele.	Avramopoulos D et al.	2002	Molecular psychiatry
12359690	Catechol O-methyltransferase genetic polymorphism in panic disorder.	Woo JM et al.	2002	The American journal of psychiatry
12402217	A highly significant association between a COMT haplotype and schizophrenia.	Shifman S et al.	2002	American journal of human genetics
12436243	Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation.	DeMille MM et al.	2002	Human genetics
12595695	COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor.	Zubieta JK et al.	2003	Science (New York, N.Y.)
12611827	Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies.	Glatt SJ et al.	2003	The American journal of psychiatry
12716966	Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.	Mattay VS et al.	2003	Proceedings of the National Academy of Sciences of the United States of America
12802784	A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.	Bray NJ et al.	2003	American journal of human genetics
12842306	A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits.	Rujescu D et al.	2003	Biological psychiatry
14966473	Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes.	Shield AJ et al.	2004	Molecular psychiatry
15098000	COMT haplotypes suggest P2 promoter region relevance for schizophrenia.	Palmatier MA et al.	2004	Molecular psychiatry
15124004	Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families.	Chen X et al.	2004	Molecular psychiatry
15169701	New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis.	Rosa A et al.	2004	The American journal of psychiatry
15290009	Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay.	Zhu G et al.	2004	Psychopharmacology
15457404	Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.	Chen J et al.	2004	American journal of human genetics
15457497	Relationship of MAO-A promoter (u-VNTR) and COMT (V158M) gene polymorphisms to CSF monoamine metabolites levels in a psychiatric sample of caucasians: A preliminary report.	Zalsman G et al.	2005	American journal of medical genetics. Part B, Neuropsychiatric genetics
15505638	Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.	Handoko HY et al.	2005	Molecular psychiatry
15645182	Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.	Lee SG et al.	2005	Human genetics
15652872	Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis.	Fan JB et al.	2005	Biological psychiatry
15821730	Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype.	Meyer-Lindenberg A et al.	2005	Nature neuroscience
15824744	Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies.	Munafò MR et al.	2005	Molecular psychiatry
15931594	An entropy-based statistic for genomewide association studies.	Zhao J et al.	2005	American journal of human genetics
15935994	COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.	Baker K et al.	2005	Biological psychiatry
15956988	COMT polymorphisms and anxiety-related personality traits.	Stein MB et al.	2005	Neuropsychopharmacology
16027741	Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.	Sweet RA et al.	2005	Molecular psychiatry
16043133	Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations.	Bruder GE et al.	2005	Biological psychiatry
16130008	Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: a family-based association study in a Chinese population.	Tsai SJ et al.	2006	Molecular psychiatry
16135635	No association between schizophrenia and polymorphisms in COMT in two large samples.	Williams HJ et al.	2005	The American journal of psychiatry
16232322	COMT genetic variation confers risk for psychotic and affective disorders: a case control study.	Funke B et al.	2005	Behavioral and brain functions
16275815	Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder.	Thapar A et al.	2005	Archives of general psychiatry
16380905	Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.	Fallin MD et al.	2005	American journal of human genetics
16380908	Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.	Hawi Z et al.	2005	American journal of human genetics
16395295	Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations.	Beuten J et al.	2006	Neuropsychopharmacology
16412218	Multilocus analysis of SNP and metabolic data within a given pathway.	Kristensen VN et al.	2006	BMC genomics
16453988	Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease.	Rissling I et al.	2006	Sleep
16483362	The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.	Dempster EL et al.	2006	BMC medical genetics
16513880	No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.	Glaser B et al.	2006	The American journal of psychiatry
16542388	Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome.	Shashi V et al.	2006	Clinical genetics
16574089	PCR screening for 22q11.2 microdeletion: development of a new cost-effective diagnostic tool.	Gioli-Pereira L et al.	2006	Clinica chimica acta; international journal of clinical chemistry
16786032	Impact of complex genetic variation in COMT on human brain function.	Meyer-Lindenberg A et al.	2006	Molecular psychiatry
16816420	Nonlinear tests for genomewide association studies.	Zhao J et al.	2006	Genetics
16816940	Direct molecular haplotyping of multiple polymorphisms within exon 4 of the human catechol-O-methyltransferase gene by liquid chromatography-electrospray ionization time-of-flight mass spectrometry.	Oberacher H et al.	2006	Analytical and bioanalytical chemistry
16837108	Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.	Borroni B et al.	2007	Neurobiology of aging
16848906	Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.	Kim H et al.	2006	Molecular pain
16882734	Genetic predictors for acute experimental cold and heat pain sensitivity in humans.	Kim H et al.	2006	Journal of medical genetics
17006672	Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.	Nicodemus KK et al.	2007	Human genetics
17116718	Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.	Cotterchio M et al.	2006	The Journal of nutrition
17299513	Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait.	Lang UE et al.	2007	Neuropsychopharmacology
17363961	Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.	Molero P et al.	2007	The pharmacogenomics journal
17427186	Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.	Yu R et al.	2007	American journal of medical genetics. Part B, Neuropsychiatric genetics
17429315	Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival.	Long JR et al.	2007	Pharmacogenetics and genomics
17442488	An association study between cathechol-O-methyltransferase gene and mental retardation in the Chinese Han population.	Zhang K et al.	2007	Neuroscience letters
17466074	Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.	Ton TG et al.	2007	Behavioral and brain functions
17482701	No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.	Nunokawa A et al.	2007	Neuroscience research
17483451	Gene-gene interaction associated with neural reward sensitivity.	Yacubian J et al.	2007	Proceedings of the National Academy of Sciences of the United States of America
17504246	Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia.	Zinkstok J et al.	2008	Genes, brain, and behavior
17504906	The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men.	Stolk L et al.	2007	The Journal of clinical endocrinology and metabolism
17548664	Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial.	Johnstone EC et al.	2007	Cancer epidemiology, biomarkers & prevention
17604122	A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population.	Ma X et al.	2007	Psychiatry research
17630406	Dopamine genes and schizophrenia: case closed or evidence pending?	Talkowski ME et al.	2007	Schizophrenia bulletin
17636223	Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata.	Gooden KM et al.	2007	Reproductive sciences (Thousand Oaks, Calif.)
17707347	Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.	Diaz-Asper CM et al.	2008	Biological psychiatry
17949513	Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.	Michaelovsky E et al.	2008	The international journal of neuropsychopharmacology
17961261	Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.	Vargas-Alarcón G et al.	2007	Arthritis research & therapy
17994190	Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults.	Retz W et al.	2008	Journal of neural transmission (Vienna, Austria
18064318	Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk.	Gellekink H et al.	2007	Thrombosis and haemostasis
18081002	Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials.	Juckel G et al.	2008	Human psychopharmacology
18180394	Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.	Fung MM et al.	2008	Circulation
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18196244	Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.	Tander B et al.	2008	Rheumatology international
18213617	Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population.	Aguilera M et al.	2008	American journal of medical genetics. Part B, Neuropsychiatric genetics
18235427	Catechol-O-methyltransferase (COMT) val158met genotype is associated with BOLD response as a function of task characteristic.	Ettinger U et al.	2008	Neuropsychopharmacology
18324659	COMT polymorphisms affecting protein expression are risk factors for endometrial cancer.	Hirata H et al.	2008	Molecular carcinogenesis
18340529	A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk.	He C et al.	2009	Breast cancer research and treatment
18351593	DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents.	Bombin I et al.	2008	American journal of medical genetics. Part B, Neuropsychiatric genetics
18384078	Association study of candidate variants of COMT with neuroticism, anxiety and depression.	Wray NR et al.	2008	American journal of medical genetics. Part B, Neuropsychiatric genetics
18389087	Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing.	Kan T et al.	2007	Bioinformatics and biology insights
18408230	Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?	Prasad KM et al.	2008	Schizophrenia bulletin
18436194	Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.	Hettema JM et al.	2008	Biological psychiatry
18444252	Neurotransmission and bipolar disorder: a systematic family-based association study.	Shi J et al.	2008	American journal of medical genetics. Part B, Neuropsychiatric genetics
18466599	Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels.	Xing C et al.	2007	BMC proceedings
18466879	Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample.	Soronen P et al.	2008	Biological psychiatry
18486967	A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A).	Shiels MS et al.	2008	Preventive medicine
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18574484	The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.	Mukherjee N et al.	2010	Molecular psychiatry
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18593984	Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms.	Bell DW et al.	2008	Clinical cancer research
18628428	Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.	Diergaarde B et al.	2008	Cancer epidemiology, biomarkers & prevention
18663369	Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR).	Strug LJ et al.	2010	Molecular psychiatry
18698234	The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications.	Bialecka M et al.	2008	Pharmacogenetics and genomics
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18715757	Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.	Shi J et al.	2008	Schizophrenia research
18755576	Effect of COMT val158met genotype on cognition and personality.	Sheldrick AJ et al.	2008	European psychiatry
18787887	Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.	Tranah GJ et al.	2008	Calcified tissue international
18802928	Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.	Halleland H et al.	2009	American journal of medical genetics. Part B, Neuropsychiatric genetics
18805939	Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.	Tempfer CB et al.	2009	Human reproduction update
18820009	Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers.	Hamaguchi M et al.	2008	Japanese journal of clinical oncology
18929622	Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy.	Huuhka K et al.	2008	Neuroscience letters
18937309	Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study.	Biederman J et al.	2008	American journal of medical genetics. Part B, Neuropsychiatric genetics
18988738	MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met.	Roffman JL et al.	2008	Proceedings of the National Academy of Sciences of the United States of America
18989660	The catechol-O-methyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting.	Benedetti F et al.	2009	Psychopharmacology
19071221	Impact of interacting functional variants in COMT on regional gray matter volume in human brain.	Honea R et al.	2009	NeuroImage
19074205	Drinking green tea modestly reduces breast cancer risk.	Shrubsole MJ et al.	2009	The Journal of nutrition
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19094200	Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.	Rakvåg TT et al.	2008	Molecular pain
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20070134	Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample.	Amstadter AB et al.	2009	Psychiatry
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20157235	Genetics of psychosis in Alzheimer's disease: a review.	DeMichele-Sweet MA et al.	2010	Journal of Alzheimer's disease
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20357209	Molecular genetic studies of gene identification for osteoporosis: the 2009 update.	Xu XH et al.	2010	Endocrine reviews
20357758	Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT.	Marenco S et al.	2010	Neuropsychopharmacology
20431430	The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness.	Salo J et al.	2010	Psychiatric genetics
20483479	Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia.	Wang Y et al.	2010	Psychiatry research
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20505544	Effect of hormone metabolism genotypes on steroid hormone levels and menopausal symptoms in a prospective population-based cohort of women experiencing the menopausal transition.	Rebbeck TR et al.	2010	Menopause (New York, N.Y.)
20509070	Association between hypnotizability and the catechol-O-methyltransferase (COMT) polymorphism.	Szekely A et al.	2010	The International journal of clinical and experimental hypnosis
20531207	The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.	Kocabas NA et al.	2010	International clinical psychopharmacology
20532872	Genetics of caffeine consumption and responses to caffeine.	Yang A et al.	2010	Psychopharmacology
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20565774	Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.	Cross DS et al.	2010	BMC genetics
20570835	No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain.	Nicholl BI et al.	2010	Annals of the rheumatic diseases
20627703	The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.	Fijal B et al.	2010	The journal of pain
20631687	Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility.	Zhang H et al.	2010	Neuropsychopharmacology
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20728009	Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism.	Demetrovics Z et al.	2010	Comprehensive psychiatry
20729390	Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women.	Olivo-Marston SE et al.	2010	Carcinogenesis
20732903	Predicting sensation seeking from dopamine genes. A candidate-system approach.	Derringer J et al.	2010	Psychological science
20863768	Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.	Dai F et al.	2010	The spine journal
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21059181	Polymorphisms of adrenergic cardiovascular control genes are associated with adolescent chronic fatigue syndrome.	Sommerfeldt L et al.	2011	Acta paediatrica (Oslo, Norway
21083670	Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD).	Hack LM et al.	2011	Alcoholism, clinical and experimental research
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21120493	Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients.	Barbosa FR et al.	2012	Rheumatology international
21130573	COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia.	Finan PH et al.	2011	Pain
21144097	The impact of the catechol-O-methyltransferase genotype on the acute responsiveness of vascular reactivity to a green tea extract.	Miller RJ et al.	2011	The British journal of nutrition
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21204206	Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population.	Carter TC et al.	2011	American journal of medical genetics. Part A
21215384	Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex.	Nixon DC et al.	2011	Biological psychiatry
21216270	Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands.	Das M et al.	2011	Progress in neuro-psychopharmacology & biological psychiatry
21217836	No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population.	Kang HJ et al.	2010	Epidemiology and health
21225419	Gene-environment interactions: early life stress and risk for depressive and anxiety disorders.	Nugent NR et al.	2011	Psychopharmacology
21280081	The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial.	Corvol JC et al.	2011	Annals of neurology
21289622	Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.	Sadee W et al.	2011	Clinical pharmacology and therapeutics
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21300759	EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients.	Yang SY et al.	2011	Clinical cancer research
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21304959	Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.	Hill LD et al.	2011	PloS one
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21330274	Pharmacogenetics of smoking cessation in general practice: results from the patch II and patch in practice trials.	David SP et al.	2011	Nicotine & tobacco research
21333900	The role of genetics in IBS.	Saito YA et al.	2011	Gastroenterology clinics of North America
21355050	A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).	Roten LT et al.	2011	Molecular human reproduction
21356266	Interactions between the COMT Val108/158Met polymorphism and maternal prenatal smoking predict aggressive behavior outcomes.	Brennan PA et al.	2011	Biological psychology
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21423693	Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.	Doehring A et al.	2011	PloS one
21440309	Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD.	Boscarino JA et al.	2011	Psychiatry research
21445667	Variation in genes involved in dopamine clearance influence the startle response in older adults.	Armbruster D et al.	2011	Journal of neural transmission (Vienna, Austria
21449006	Role of COMT, 5-HT(1A) , and SERT genetic polymorphisms on antidepressant response to Transcranial Magnetic Stimulation.	Malaguti A et al.	2011	Depression and anxiety
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21593733	Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity.	Nikolova YS et al.	2011	Neuropsychopharmacology
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21749372	Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects.	Luijk MP et al.	2011	Journal of child psychology and psychiatry, and allied disciplines
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21895373	Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism.	Desmeules J et al.	2012	Health psychology
21905019	Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia.	Smith SB et al.	2012	Arthritis and rheumatism
21934638	A COMT gene haplotype associated with methamphetamine abuse.	Jugurnauth SK et al.	2011	Pharmacogenetics and genomics
21934689	Is there a genetic cause for cancer cachexia? - a clinical validation study in 1797 patients.	Solheim TS et al.	2011	British journal of cancer
21935354	Phased whole-genome genetic risk in a family quartet using a major allele reference sequence.	Dewey FE et al.	2011	PLoS genetics
21940152	The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder--a European multicenter study.	Schosser A et al.	2012	European neuropsychopharmacology
21947654	Cannabis, COMT and psychotic experiences.	Zammit S et al.	2011	The British journal of psychiatry
21958689	Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes.	Trabert B et al.	2011	Fertility and sterility
21999147	Diverse facets of COMT: from a plausible predictive marker to a potential drug target for schizophrenia.	Gupta M et al.	2011	Current molecular medicine
22021659	Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia.	Roffman JL et al.	2013	Schizophrenia bulletin
22021758	Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort.	Nyman ES et al.	2011	BMJ open
22024213	A novel gene-environment interaction involved in endometriosis.	McCarty CA et al.	2012	International journal of gynaecology and obstetrics
22024485	Genetic associations with performance on a behavioral measure of distress intolerance.	Amstadter AB et al.	2012	Journal of psychiatric research
22067551	When control fails: influence of the prefrontal but not striatal dopaminergic system on behavioural flexibility in a change detection task.	Schulz S et al.	2012	Neuropharmacology
22087305	BDNF polymorphism predicts general intelligence after penetrating traumatic brain injury.	Rostami E et al.	2011	PloS one
22103610	Biomarkers to optimize the treatment of nicotine dependence.	Schnoll RA et al.	2011	Biomarkers in medicine
22105624	The genetics of attention deficit/hyperactivity disorder in adults, a review.	Franke B et al.	2012	Molecular psychiatry
22170288	Translational genetic approaches to substance use disorders: bridging the gap between mice and humans.	Palmer AA et al.	2012	Human genetics
22178088	Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome.	Hill LD et al.	2012	Molecular and cellular endocrinology
22224195	Epigenetics in Developmental Disorder: ADHD and Endophenotypes.	Archer T et al.	2011	Journal of genetic syndromes & gene therapy
22259185	Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity.	Varga G et al.	2012	American journal of medical genetics. Part B, Neuropsychiatric genetics
22293393	Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity.	Hiyoshi M et al.	2012	Gene
22301281	Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk.	Jang JH et al.	2012	Carcinogenesis
22337560	The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation.	Jacobsen LM et al.	2012	European journal of pain (London, England)
22348020	Exogenous visual orienting is associated with specific neurotransmitter genetic markers: a population-based genetic association study.	Lundwall RA et al.	2012	PloS one
22349272	Age modulates the effect of COMT genotype on delay discounting behavior.	Smith CT et al.	2012	Psychopharmacology
22366815	Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data.	Brandys MK et al.	2012	Psychiatric genetics
22367361	Replication study for reported SNP associations with breast cancer survival.	Beeghly-Fadiel A et al.	2012	Journal of cancer research and clinical oncology
22418777	Estrogen-related genes and their contribution to racial differences in breast cancer risk.	Reding KW et al.	2012	Cancer causes & control
22438994	Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test.	Lim J et al.	2012	PloS one
22451510	Catechol-o-methyltransferase gene and executive function in children with ADHD.	Choudhry Z et al.	2014	Journal of attention disorders
22466345	Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women.	Butts SF et al.	2012	The Journal of clinical endocrinology and metabolism
22487365	C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate.	Huertas E et al.	2012	Genes, brain, and behavior
22528689	Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene.	Martínez-Jauand M et al.	2013	European journal of pain (London, England)
22530780	Impact of five SNPs in dopamine-related genes on executive function.	Mitaki S et al.	2013	Acta neurologica Scandinavica
22535570	Is there a genetic cause of appetite loss?-an explorative study in 1,853 cancer patients.	Solheim TS et al.	2012	Journal of cachexia, sarcopenia and muscle
22536069	Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment.	Boscarino JA et al.	2012	Neuropsychiatric disease and treatment
22552919	Bioinformatics and variability in drug response: a protein structural perspective.	Lahti JL et al.	2012	Journal of the Royal Society, Interface
22615781	Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.	Bakker PR et al.	2012	PloS one
22623973	An improved PSO algorithm for generating protective SNP barcodes in breast cancer.	Chuang LY et al.	2012	PloS one
22640745	The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD.	Matthews N et al.	2012	Behavioral and brain functions
22645715	Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study.	Heck JE et al.	2012	Frontiers in oncology
22655260	Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations.	Kalari KR et al.	2012	Frontiers in oncology
22658813	Association between polymorphisms in COMT, PLCH1, and CYP17A1, and non-small-cell lung cancer risk in Chinese nonsmokers.	Zhang Y et al.	2013	Clinical lung cancer
22683321	Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology.	Thaler L et al.	2012	Progress in neuro-psychopharmacology & biological psychiatry
22695756	Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy.	Sun H et al.	2012	Journal of neural transmission (Vienna, Austria
22701660	Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guérin.	Wei H et al.	2012	PloS one
22713126	COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder.	Soeiro-de-Souza MG et al.	2012	Bipolar disorders
22718527	The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation.	Henker RA et al.	2013	Biological research for nursing
22719919	Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study.	dos Santos VA et al.	2012	PloS one
22722321	Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis.	Tammimäki A et al.	2012	Pharmacogenetics and genomics
22763378	Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms.	Shashi V et al.	2012	European journal of human genetics
22784685	The COMT Met158 allele and violence in schizophrenia: a meta-analysis.	Bhakta SG et al.	2012	Schizophrenia research
22832657	A review on experimental and clinical genetic associations studies on fear conditioning, extinction and cognitive-behavioral treatment.	Lonsdorf TB et al.	2011	Translational psychiatry
22832821	Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development.	Ziermans T et al.	2012	Translational psychiatry
22841130	Shared and unique genetic contributions to attention deficit/hyperactivity disorder and substance use disorders: a pilot study of six candidate genes.	Carpentier PJ et al.	2013	European neuropsychopharmacology
22890010	Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.	Białecka M et al.	2012	Pharmacogenetics and genomics
22890094	Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients.	Lanni C et al.	2012	Journal of Alzheimer's disease
22900954	COMT val158met predicts reward responsiveness in humans.	Lancaster TM et al.	2012	Genes, brain, and behavior
22901597	Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia.	Poletti S et al.	2013	Comprehensive psychiatry
22956598	Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.	Peters MJ et al.	2013	Annals of the rheumatic diseases
22963930	Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent.	Al-Eitan LN et al.	2012	BMC research notes
22978509	Convergence of genome-wide association and candidate gene studies for alcoholism.	Olfson E et al.	2012	Alcoholism, clinical and experimental research
22992668	Pharmacogenomics knowledge for personalized medicine.	Whirl-Carrillo M et al.	2012	Clinical pharmacology and therapeutics
23000097	Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women.	Martínez-Ramírez OC et al.	2013	Breast (Edinburgh, Scotland)
23008195	Genetic variants in the catechol-o-methyltransferase gene are associated with impulsivity and executive function: relevance for major depression.	Pap D et al.	2012	American journal of medical genetics. Part B, Neuropsychiatric genetics
23069674	No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias.	Creese B et al.	2012	Neuroscience letters
23112845	Epistasis analysis for estrogen metabolic and signaling pathway genes on young ischemic stroke patients.	Hsieh YC et al.	2012	PloS one
23133420	Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.	Suarez-Kurtz G et al.	2012	Frontiers in pharmacology
23139742	Functional analyses of endometriosis-related polymorphisms in the estrogen synthesis and metabolism-related genes.	Wang HS et al.	2012	PloS one
23141115	The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity in patients with panic disorder.	Kim B et al.	2013	Journal of affective disorders
23178897	The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.	Gaysina D et al.	2013	Biological psychology
23209597	Investigating the genetic basis of theory of mind (ToM): the role of catechol-O-methyltransferase (COMT) gene polymorphisms.	Xia H et al.	2012	PloS one
23219927	Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism.	Zhang X et al.	2013	NeuroImage
23226061	The role of genetics in pre-eclampsia and potential pharmacogenomic interventions.	Williams PJ et al.	2012	Pharmacogenomics and personalized medicine
23248619	Chemotherapy refractory testicular germ cell tumor is associated with a variant in Armadillo Repeat gene deleted in Velco-Cardio-Facial syndrome (ARVCF).	Fung C et al.	2012	Frontiers in endocrinology
23261162	DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task.	Spronk DB et al.	2013	Clinical neurophysiology
23278923	The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation.	Landi N et al.	2013	Developmental science
23283688	Common variants in psychiatric risk genes predict brain structure at birth.	Knickmeyer RC et al.	2014	Cerebral cortex (New York, N.Y.
23288874	Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study.	Mutschler J et al.	2013	Nicotine & tobacco research
23302985	The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia.	Landau R et al.	2013	Anesthesia and analgesia
23351565	Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability.	Hatzimanolis A et al.	2013	Journal of affective disorders
23353103	COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study.	Kontis D et al.	2013	Neuroscience letters
23358850	Genetic variants in sex hormone metabolic pathway genes and risk of esophageal squamous cell carcinoma.	Hyland PL et al.	2013	Carcinogenesis
23370603	Catechol-O-methyltransferase and cytochrome P-450 1B1 polymorphisms and endometrial cancer risk: a meta-analysis.	Teng Y et al.	2013	International journal of gynecological cancer
23408064	The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism.	Klebe S et al.	2013	Journal of neurology, neurosurgery, and psychiatry
23421762	COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.	Wang Y et al.	2013	Genes, brain, and behavior
23429840	Prepulse inhibition of startle response: recent advances in human studies of psychiatric disease.	Takahashi H et al.	2011	Clinical psychopharmacology and neuroscience
23440431	Association of the COMT Met¹⁵⁸ allele with trait impulsivity in healthy young adults.	Soeiro-De-Souza MG et al.	2013	Molecular medicine reports
23459442	COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers.	Herman AI et al.	2013	The pharmacogenomics journal
23598060	Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia.	Liu X et al.	2013	Psychiatry research
23618651	Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depressive disorder.	Seok JH et al.	2013	Neuroscience letters
23632726	Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome.	Wachman EM et al.	2013	JAMA
23706899	Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder.	Hopkins SC et al.	2013	Psychiatry research
23715639	The association between the catechol-O-methyltransferase Val108/158Met polymorphism and hyperactive-impulsive and inattentive symptoms in youth.	Nikolac Perkovic M et al.	2013	Psychopharmacology
23728717	Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample.	Ojeda DA et al.	2014	Neurological sciences
23733030	Pharmacogenetics in major depression: a comprehensive meta-analysis.	Niitsu T et al.	2013	Progress in neuro-psychopharmacology & biological psychiatry
23762769	Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599.	Maria K et al.	2012	ISRN psychiatry
23766564	Pharmacogenetics of chronic pain and its treatment.	Světlík S et al.	2013	Mediators of inflammation
23769684	Apathy is associated with a single-nucleotide polymorphism in a dopamine-related gene.	Mitaki S et al.	2013	Neuroscience letters
23773341	An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans.	Cargnin S et al.	2013	The journal of pain
23774690	Distribution of the Val108/158Met polymorphism of the COMT gene in healthy Mexican population.	González-Castro TB et al.	2013	Gene
23785672	Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans.	Ghisari M et al.	2013	International journal of circumpolar health
23793356	Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls.	Falcone M et al.	2013	Neuropsychopharmacology
23808549	Candidate gene associations with withdrawn behavior.	Rubin DH et al.	2013	Journal of child psychology and psychiatry, and allied disciplines
23818048	Gender effects of the COMT Val 158 Met genotype on verbal fluency in healthy adults.	Soeiro-De-Souza MG et al.	2013	Molecular medicine reports
23856854	Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders.	McCracken JT et al.	2014	The pharmacogenomics journal
23880798	No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women.	Passarelli MN et al.	2014	Menopause (New York, N.Y.)
23910792	Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes.	Zarchi O et al.	2013	Journal of psychiatric research
23922910	A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk.	Kelly LE et al.	2013	PloS one
23927501	Why it is hard to find genes associated with social science traits: theoretical and empirical considerations.	Chabris CF et al.	2013	American journal of public health
23928748	Impact of COMT genotype on serotonin-1A receptor binding investigated with PET.	Baldinger P et al.	2014	Brain structure & function
23932573	Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort.	Kukshal P et al.	2013	Journal of psychiatric research
23941313	Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion.	David SP et al.	2013	Addiction (Abingdon, England)
23946381	Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.	Ma X et al.	2014	Gut
23954148	The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism.	Vinkers CH et al.	2013	Schizophrenia research
23963787	Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision.	Bortsov AV et al.	2014	Neuromolecular medicine
24013564	Use of extremely short Förster resonance energy transfer probes in real-time polymerase chain reaction.	Kutyavin IV et al.	2013	Nucleic acids research
24086514	Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study.	Beer B et al.	2013	PloS one
24118915	The interaction of early life experiences with COMT val158met affects anxiety sensitivity.	Baumann C et al.	2013	Genes, brain, and behavior
24128936	PharmGKB summary: venlafaxine pathway.	Sangkuhl K et al.	2014	Pharmacogenetics and genomics
24144248	Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load.	Smith CT et al.	2014	Journal of cognitive neuroscience
24145376	Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans.	Papaleo F et al.	2014	Molecular psychiatry
24178190	Influence of variation in the catechol-O-methyltransferase gene on the clinical outcome after lumbar spine surgery for one-level symptomatic disc disease: a report on 176 cases.	Rut M et al.	2014	Acta neurochirurgica
24201053	Pharmacogenetics of OPRM1.	Crist RC et al.	2014	Pharmacology, biochemistry, and behavior
24225542	Association of COMT val158met and DRD2 G>T genetic polymorphisms with individual differences in motor learning and performance in female young adults.	Noohi F et al.	2014	Journal of neurophysiology
24274352	Green tea consumption and breast cancer risk in Japanese women: a case-control study.	Iwasaki M et al.	2014	Nutrition and cancer
24290452	Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis.	Fernández-de-las-Peñas C et al.	2013	The journal of pain
24319431	Mechanisms of antidepressant resistance.	El-Hage W et al.	2013	Frontiers in pharmacology
24373005	Association analysis of the catechol-O-methyltransferase /methylenetetrahydrofolate reductase genes and cognition in late-onset depression.	Wang X et al.	2014	Psychiatry and clinical neurosciences
24390676	COMT Associations with Disordered Gambling and Drinking Measures.	Guillot CR et al.	2015	Journal of gambling studies
24407958	Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures.	Bühler KM et al.	2014	Molecular genetics and genomics
24448899	Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype.	Zhang Y et al.	2014	Psychopharmacology
24495967	Common polymorphisms in dopamine-related genes combine to produce a 'schizophrenia-like' prefrontal hypoactivity.	Vercammen A et al.	2014	Translational psychiatry
24499375	Association of oxidative stress-related genes with idiopathic recurrent miscarriage.	Khadzhieva MB et al.	2014	Free radical research
24508446	Gene×gene×gender interaction of BDNF and COMT genotypes associated with panic disorder.	Konishi Y et al.	2014	Progress in neuro-psychopharmacology & biological psychiatry
24555772	Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression.	Chiesa A et al.	2014	International journal of psychiatry in clinical practice
24589356	Association between genes, stressful childhood events and processing bias in depression vulnerable individuals.	Vrijsen JN et al.	2014	Genes, brain, and behavior
24625311	Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults.	Valomon A et al.	2014	Chronobiology international
24629213	Polymorphisms in phase I and phase II genes and breast cancer risk and relations to persistent organic pollutant exposure: a case-control study in Inuit women.	Ghisari M et al.	2014	Environmental health
24656901	Factors affecting cognitive remediation response in schizophrenia: the role of COMT gene and antipsychotic treatment.	Bosia M et al.	2014	Psychiatry research
24684248	Functional polymorphisms in COMT and SLC6A4 genes influence the prognosis of patients with medication overuse headache after withdrawal therapy.	Cargnin S et al.	2014	European journal of neurology
24711381	Social disadvantage, genetic sensitivity, and children's telomere length.	Mitchell C et al.	2014	Proceedings of the National Academy of Sciences of the United States of America
24755993	Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?	Bakker JM et al.	2014	Translational psychiatry
24782743	Association of COMT and COMT-DRD2 interaction with creative potential.	Zhang S et al.	2014	Frontiers in human neuroscience
24819480	COMT gene and risk for Parkinson's disease: a systematic review and meta-analysis.	Jiménez-Jiménez FJ et al.	2014	Pharmacogenetics and genomics
24842701	PRKCA polymorphism changes the neural basis of episodic remembering in healthy individuals.	MacLeod CA et al.	2014	PloS one
24853458	Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects.	Carmel M et al.	2014	Journal of psychiatric research
24860514	Gene-environment interactions in severe mental illness.	Uher R et al.	2014	Frontiers in psychiatry
24862404	Exploring the indirect effects of catechol-O-methyltransferase (COMT) genotype on psychotic experiences through cognitive function and anxiety disorders in a large birth cohort of children.	Niarchou M et al.	2014	American journal of medical genetics. Part B, Neuropsychiatric genetics
24881125	From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment.	Fabbri C et al.	2014	Canadian journal of psychiatry. Revue canadienne de psychiatrie
24889756	Preliminary investigation of the influence of dopamine regulating genes on social working memory.	Dumontheil I et al.	2014	Social neuroscience
24904231	A novel catechol-O-methyltransferase variant associated with human disc degeneration.	Gruber HE et al.	2014	International journal of medical sciences
24904437	Gone to Pot - A Review of the Association between Cannabis and Psychosis.	Radhakrishnan R et al.	2014	Frontiers in psychiatry
24937821	Vitiligo--part 1.	Tarlé RG et al.	2014	Anais brasileiros de dermatologia
24944790	Screening for 392 polymorphisms in 141 pharmacogenes.	Kim JY et al.	2014	Biomedical reports
24955500	Perceived stress during pregnancy and the catechol-O-methyltransferase (COMT) rs165599 polymorphism impacts on childhood IQ.	Lamb YN et al.	2014	Cognition
24972245	The activity of catechol-O-methyltransferase (COMT) is not impaired by high doses of epigallocatechin-3-gallate (EGCG) in vivo.	Lorenz M et al.	2014	European journal of pharmacology
24990354	Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring.	Liu J et al.	2015	Metabolic brain disease
24996618	Host genetic factors predisposing to HIV-associated neurocognitive disorder.	Kallianpur AR et al.	2014	Current HIV/AIDS reports
25012481	Association study of two steroid biosynthesis genes (COMT and CYP17) with Alzheimer's disease in the Italian population.	Corbo RM et al.	2014	Journal of the neurological sciences
25017045	The neurobiological link between OCD and ADHD.	Brem S et al.	2014	Attention deficit and hyperactivity disorders
25035343	Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease.	Hall KT et al.	2014	Arteriosclerosis, thrombosis, and vascular biology
25040948	The design and methods of genetic studies on acute and chronic postoperative pain in patients after total knee replacement.	Belfer I et al.	2014	Pain medicine (Malden, Mass.)
25045629	Is catechol-o-methyltransferase gene polymorphism a risk factor in the development of premenstrual syndrome?	Deveci EO et al.	2014	Clinical and experimental reproductive medicine
25048416	Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children.	Cote AT et al.	2015	The pharmacogenomics journal
25063767	Interactions Between Early Trauma and Catechol-O-Methyltransferase Genes on Inhibitory Deficits in Children With ADHD.	Park S et al.	2017	Journal of attention disorders
25080285	Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study.	Nombela C et al.	2014	Brain
25102390	Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.	Jhun E et al.	2014	Anesthesia and analgesia
25159270	Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility.	Sulik MJ et al.	2015	Development and psychopathology
25184405	Subclinical psychotic experiences in healthy young adults: associations with stress and genetic predisposition.	Bruenig D et al.	2014	Genetic testing and molecular biomarkers
25185591	Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain.	Candiotti KA et al.	2014	Anesthesia and analgesia
25195915	The mediating effect of prefrontal asymmetry on the relationship between the COMT Val(158)Met SNP and trait consummatory positive affect.	Katz AC et al.	2015	Cognition & emotion
25218601	Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.	Smith SB et al.	2014	Pain
25238062	The role of catechol-O-methyl transferase Val(108/158)Met polymorphism (rs4680) in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study.	Hursel R et al.	2014	PloS one
25239657	Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene.	van Blitterswijk M et al.	2014	Molecular neurodegeneration
25266489	Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China.	Zhang J et al.	2014	BMC genetics
25280560	Association between Catechol-O-methyltransferase rs4680 (G>A) polymorphism and lung cancer risk.	Tan X et al.	2014	Diagnostic pathology
25324626	Research in China on the molecular genetics of schizophrenia.	Cui D et al.	2012	Shanghai archives of psychiatry
25325218	Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes.	Radoeva PD et al.	2014	Psychiatric genetics
25365808	Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine-related loci.	Gray JC et al.	2014	Brain and behavior
25491588	Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population.	Shibata N et al.	2015	International journal of geriatric psychiatry
25495556	Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study.	Villemonteix T et al.	2015	The world journal of biological psychiatry
25510197	Dopamine and cognitive control: sex-by-genotype interactions influence the capacity to switch attention.	Gurvich C et al.	2015	Behavioural brain research
25515329	Genetic predictor of working memory and prefrontal function in women with HIV.	Sundermann EE et al.	2015	Journal of neurovirology
25532715	COMT gene haplotypes are closely associated with postoperative fentanyl dose in patients.	Zhang F et al.	2015	Anesthesia and analgesia
25545355	Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents.	O'Loughlin J et al.	2014	PloS one
25556215	Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children's intelligence in endemic fluorosis area in Tianjin, China.	Zhang S et al.	2015	Toxicological sciences
25560469	COMT Val158Met and 5-HT1A-R -1019 C/G polymorphisms: effects on the negative symptom response to clozapine.	Bosia M et al.	2015	Pharmacogenomics
25636089	[Polymorphisms of catechol-O-methyltransferase and monoamine oxidase B genes among Chinese patients with Parkinson's disease].	Hao H et al.	2015	Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
25658328	Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.	Banlaki Z et al.	2015	PloS one
25663728	A neurogenetics approach to defining differential susceptibility to institutional care.	Brett ZH et al.	2015	International journal of behavioral development
25741868	Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.	Richards S et al.	2015	Genetics in medicine
25744938	A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.	Wang LJ et al.	2015	Scientific reports
25753458	Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease.	Muellner J et al.	2015	Parkinsonism & related disorders
25805645	Polymorphism of the dopamine transporter type 1 gene modifies the treatment response in Parkinson's disease.	Moreau C et al.	2015	Brain
25819021	A review of pharmacogenetic studies of substance-related disorders.	Jones JD et al.	2015	Drug and alcohol dependence
25912540	Effect of polymorphisms of three genes mediating monoamine signalling on brain morphometry in schizophrenia and healthy subjects.	Vijayakumari AA et al.	2015	Clinical psychopharmacology and neuroscience
25927430	Association of DRD3, COMT, and SLC6A4 Gene Polymorphisms with Type 2 Diabetes in Southern Chinese: A Hospital-Based Case-Control Study.	Xiu L et al.	2015	Diabetes technology & therapeutics
25929431	Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study.	De Marchis ML et al.	2015	The journal of headache and pain
25936248	Genetic Basis of the Relationship Between Reproduction and Longevity: A Study on Common Variants of Three Genes in Steroid Hormone Metabolism--CYP17, HSD17B1, and COMT.	Scarabino D et al.	2015	Rejuvenation research
25948405	Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors?	Currow DC et al.	2015	BMJ open
25960587	A Genetic Variant (COMT) Coding Dopaminergic Activity Predicts Personality Traits in Healthy Elderly.	Kotyuk E et al.	2015	Personality and individual differences
25963335	Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy.	Tan EC et al.	2016	The pharmacogenomics journal
25974322	Association of TMEM132D, COMT, and GABRA6 genotypes with cingulate, frontal cortex and hippocampal emotional processing in panic and major depressive disorder.	Inoue A et al.	2015	International journal of psychiatry in clinical practice
25987236	Functional variants in CYP1B1, KRAS and MTHFR genes are associated with shorter telomere length in postmenopausal women.	Cerne JZ et al.	2015	Mechanisms of ageing and development
26026741	Lack of association between COMT polymorphism rs4680 and risk of Alzheimer's disease in Asians: Evidence from a meta-analysis.	Zhang G et al.	2015	Psychiatry research
26028545	COMT genotype, gambling activity, and cognition.	Grant JE et al.	2015	Journal of psychiatric research
26044620	Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.	Reyes-Gibby CC et al.	2015	BMC systems biology
26053146	Child exposure to serious life events, COMT, and aggression: Testing differential susceptibility theory.	Hygen BW et al.	2015	Developmental psychology
26091847	Genetic polymorphisms of pharmacogenomic VIP variants in the Uygur population from northwestern China.	Wang L et al.	2015	BMC genetics
26147675	Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population.	Dong Z et al.	2015	PloS one
26189450	Genetic Moderation of Stress Effects on Corticolimbic Circuitry.	Bogdan R et al.	2016	Neuropsychopharmacology
26220612	Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes.	MacKillop J et al.	2015	Psychopharmacology
26245713	Association of COMT and SLC6A3 polymorphisms with impulsivity, response inhibition and brain function.	Kasparbauer AM et al.	2015	Cortex; a journal devoted to the study of the nervous system and behavior
26253436	Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis.	Watanabe K et al.	2015	Psychiatry research
26260058	Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth.	Christiaens I et al.	2015	BMC medical genetics
26272340	Polymorphism in COMT is associated with IgG3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome.	Löbel M et al.	2015	Journal of translational medicine
26272535	The placebo effect: From concepts to genes.	Colagiuri B et al.	2015	Neuroscience
26322144	<i>COMT</i> and <i>OPRM1</i> Genotype Associations with Daily Knee Pain Variability and Activity Induced Pain.	Martire LM et al.	2016	Scandinavian journal of pain
26322220	A comprehensive meta-analysis of common genetic variants in autism spectrum conditions.	Warrier V et al.	2015	Molecular autism
26345603	Predictors of heroin relapse: Personality traits, impulsivity, COMT gene Val158met polymorphism in a 5-year prospective study in Shanghai, China.	Su H et al.	2015	American journal of medical genetics. Part B, Neuropsychiatric genetics
26362601	Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study.	DeCarlo CA et al.	2016	The journals of gerontology. Series B, Psychological sciences and social sciences
26390831	Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways.	Howe AS et al.	2016	Molecular psychiatry
26394291	Influence of Catechol-O-methyltransferase on Executive Functioning Longitudinally After Early Childhood Traumatic Brain Injury: Preliminary Findings.	Kurowski BG et al.	2016	The Journal of head trauma rehabilitation
26483654	Linking unfounded beliefs to genetic dopamine availability.	Schmack K et al.	2015	Frontiers in human neuroscience
26486601	Interaction Between Season of Birth and COMT Val158Met (rs4680) in ADHD in a Large Sample of Chinese Han Participants.	Gao Q et al.	2018	Journal of attention disorders
26489634	Association of single nucleotide polymorphisms of ABCB1, OPRM1 and COMT with pain perception in cancer patients.	Wang XS et al.	2015	Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
26508970	Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder.	Park S et al.	2015	Psychiatry investigation
26543368	Epidemiological support for genetic variability at hypothalamic-pituitary-adrenal axis and serotonergic system as risk factors for major depression.	Ching-López A et al.	2015	Neuropsychiatric disease and treatment
26555332	Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: a meta-analysis.	Choi HD et al.	2015	Pharmacogenomics
26560848	The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder.	Jin J et al.	2016	Genes, brain, and behavior
26572896	Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype.	Spronk DB et al.	2016	Psychopharmacology
26580694	A Dopamine Pathway Gene Risk Score for Cognitive Recovery Following Traumatic Brain Injury: Methodological Considerations, Preliminary Findings, and Interactions With Sex.	Myrga JM et al.	2016	The Journal of head trauma rehabilitation
26616111	Disorder-specific genetic factors in obsessive-compulsive disorder: A comprehensive meta-analysis.	Taylor S et al.	2016	American journal of medical genetics. Part B, Neuropsychiatric genetics
26627480	Genetic predisposition to acute kidney injury--a systematic review.	Vilander LM et al.	2015	BMC nephrology
26642826	Network-Dependent Modulation of COMT and DRD2 Polymorphisms in Healthy Young Adults.	Zhao F et al.	2015	Scientific reports
26687156	Catechol-O-Methyltransferase Gene Polymorphisms in Specific Obsessive-Compulsive Disorder Patients' Subgroups.	Melo-Felippe FB et al.	2016	Journal of molecular neuroscience
26724569	Catechol-O-methyltransferase gene variants may associate with negative symptom response and plasma concentrations of prolactin in schizophrenia after amisulpride treatment.	Chen CY et al.	2016	Psychoneuroendocrinology
26745992	Catechol-O-Methyltransferase Val158Met Polymorphism and Clinical Response to Antipsychotic Treatment in Schizophrenia and Schizo-Affective Disorder Patients: a Meta-Analysis.	Huang E et al.	2016	The international journal of neuropsychopharmacology
26746237	Attention deficit hyperactivity disorder: genetic association study in a cohort of Spanish children.	Gomez-Sanchez CI et al.	2016	Behavioral and brain functions
26756273	Genetics of psychosis of Alzheimer disease.	Shah C et al.	2017	American journal of medical genetics. Part B, Neuropsychiatric genetics
26803486	Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity.	Wang M et al.	2016	Journal of neuroimmune pharmacology
26808641	Dopamine receptor D2 and catechol-O-methyltransferase gene polymorphisms associated with anorexia nervosa in Chinese Han population: DRD2 and COMT gene polymorphisms were associated with AN.	Peng S et al.	2016	Neuroscience letters
26839669	The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children.	Lee MG et al.	2016	The Korean journal of pain
26849490	Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.	Park DJ et al.	2016	European journal of pain (London, England)
26858644	Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling.	Chua EW et al.	2016	Frontiers in pharmacology
26902643	Human Genetic Variability Contributes to Postoperative Morphine Consumption.	De Gregori M et al.	2016	The journal of pain
26917235	COMT Val158Met polymorphism influences the susceptibility to framing in decision-making: OFC-amygdala functional connectivity as a mediator.	Gao X et al.	2016	Human brain mapping
26926883	Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.	Gluskin BS et al.	2016	Translational psychiatry
26954460	COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex.	Dean B et al.	2016	American journal of medical genetics. Part B, Neuropsychiatric genetics
26986136	The Association Between Genetic Variants in the Dopaminergic System and Posttraumatic Stress Disorder: A Meta-Analysis.	Li L et al.	2016	Medicine
26988620	No associations between five polymorphisms in COMT gene and migraine.	Takigawa H et al.	2017	Acta neurologica Scandinavica
26989097	Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.	Coleman JR et al.	2016	The British journal of psychiatry
27004987	Interaction of COMT rs4680 and BDNF rs6265 polymorphisms on functional connectivity density of the left frontal eye field in healthy young adults.	Li W et al.	2016	Human brain mapping
27015811	Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents.	Kim KN et al.	2016	Environmental health
27020768	The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.	González-Castro TB et al.	2016	Neuromolecular medicine
27027462	Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation.	Elens L et al.	2016	Therapeutic drug monitoring
27039372	Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder.	Flowers SA et al.	2016	BMC psychology
27061127	Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model - An Explorative Study.	Nielsen LM et al.	2016	Basic & clinical pharmacology & toxicology
27061230	The ABCB1, rs9282564, AG and TT Genotypes and the COMT, rs4680, AA Genotype are Less Frequent in Deceased Patients with Opioid Addiction than in Living Patients with Opioid Addiction.	Christoffersen DJ et al.	2016	Basic & clinical pharmacology & toxicology
27074016	Polymorphisms of Estrogen Metabolism-Related Genes and Prostate Cancer Risk in Two Populations of African Ancestry.	Brureau L et al.	2016	PloS one
27091610	COMT, BDNF, and DTNBP1 polymorphisms and cognitive functions in patients with brain tumors.	Correa DD et al.	2016	Neuro-oncology
27103528	Association of genetic risk factors with cognitive decline: the PATH through life project.	Andrews SJ et al.	2016	Neurobiology of aging
27138112	COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.	Corral-Frías NS et al.	2016	Genes, brain, and behavior
27166759	Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.	Yang J et al.	2016	Molecular psychiatry
27203226	The COMT rs4680 polymorphism and suicide attempt in rural Shandong, China.	Sun SH et al.	2016	Psychiatric genetics
27217152	Attention-deficit hyperactivity disorder in adults: A systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies.	Bonvicini C et al.	2016	Molecular psychiatry
27233804	Genetic polymorphisms of pharmacogenomic VIP variants in the Mongol of Northwestern China.	Jin T et al.	2016	BMC genetics
27241058	COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review.	Schacht JP et al.	2016	The pharmacogenomics journal
27247849	Genetic variation and cognitive dysfunction in opioid-treated patients with cancer.	Kurita GP et al.	2016	Brain and behavior
27282867	Catechol-O-methyltransferase association with hemoglobin A1c.	Hall KT et al.	2016	Metabolism
27322568	Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype.	Narendran R et al.	2016	PloS one
27347613	Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study.	Seib C et al.	2016	Genetic testing and molecular biomarkers
27375535	Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review.	Taub DR et al.	2016	Frontiers in psychology
27446594	Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population.	Goto A et al.	2016	Journal of pharmaceutical health care and sciences
27457818	Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome.	Hall KT et al.	2016	The pharmacogenomics journal
27458023	Manic symptom severity correlates with COMT activity in the striatum: A post-mortem study.	Bortolato M et al.	2017	The world journal of biological psychiatry
27521242	TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs.	Xu Z et al.	2016	The international journal of neuropsychopharmacology
27610078	MAOA Influences the Trajectory of Attentional Development.	Lundwall RA et al.	2016	Frontiers in human neuroscience
27642547	Genetic and Environmental Factors Associated with Cannabis Involvement.	Bogdan R et al.	2016	Current addiction reports
27649267	Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain.	Somogyi AA et al.	2016	Pain
27716216	The Anatomy to Genomics (ATG) Start Genetics medical school initiative: incorporating exome sequencing data from cadavers used for Anatomy instruction into the first year curriculum.	Gerhard GS et al.	2016	BMC medical genomics
27721799	Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions.	Mirkovic B et al.	2016	Frontiers in psychiatry
27743374	Associations between genetic risk, functional brain network organization and neuroticism.	Servaas MN et al.	2017	Brain imaging and behavior
27757066	Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations.	Eum S et al.	2016	Dialogues in clinical neuroscience
27780702	Catechol-O-methyltransferase gene polymorphism and vulvar pain in women with vulvodynia.	Patanwala IY et al.	2017	American journal of obstetrics and gynecology
27883295	Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer.	Sissung TM et al.	2016	Pharmacogenomics
27895608	Genetic Consideration of Schizotypal Traits: A Review.	Walter EE et al.	2016	Frontiers in psychology
27903758	OPRM1 and COMT Gene-Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma.	Khalil H et al.	2017	Biological research for nursing
27909454	Linkage and Association Analyses of Schizophrenia with Genetic Variations on Chromosome 22q11 in Koreans.	Yoon SC et al.	2016	Psychiatry investigation
27964712	Genes associated with persistent lumbar radicular pain; a systematic review.	Bjorland S et al.	2016	BMC musculoskeletal disorders
27974137	Health effects associated with measured levels of contaminants in the Arctic.	Weihe P et al.	2016	International journal of circumpolar health
27983768	Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity.	Wachman EM et al.	2017	The American journal on addictions
28049082	Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorder.	Vai B et al.	2017	European psychiatry
28060209	Catechol-O-Methyltransferase Genotypes and Parenting Influence on Long-Term Executive Functioning After Moderate to Severe Early Childhood Traumatic Brain Injury: An Exploratory Study.	Kurowski BG et al.	2017	The Journal of head trauma rehabilitation
28078547	ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults.	Xu Q et al.	2018	Brain imaging and behavior
28084056	Genetic Influences of OPRM1, OPRD1 and COMT on Morphine Analgesia in a Multi-Modal, Multi-Tissue Human Experimental Pain Model.	Nielsen LM et al.	2017	Basic & clinical pharmacology & toxicology
28085950	Impact of DRD2/ANKK1 and COMT Polymorphisms on Attention and Cognitive Functions in Schizophrenia.	Nkam I et al.	2017	PloS one
28089731	Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine.	Sutherland HG et al.	2017	Gene
28096880	Genetic Polymorphism of 1019C/G (rs6295) Promoter of Serotonin 1A Receptor and Catechol-O-Methyltransferase in Panic Disorder.	Watanabe T et al.	2017	Psychiatry investigation
28102561	Stressful life events and catechol-O-methyl-transferase (COMT) gene in bipolar disorder.	Hosang GM et al.	2017	Depression and anxiety
28127926	5-HTTLPR and DISC1 risk genotypes for elevated PTSD symptoms in US military veterans.	Young KA et al.	2017	World psychiatry
28157646	Polymorphism in xenobiotic and estrogen metabolizing genes, exposure to perfluorinated compounds and subsequent breast cancer risk: A nested case-control study in the Danish National Birth Cohort.	Ghisari M et al.	2017	Environmental research
28178648	Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer.	Kuo SH et al.	2017	Oncotarget
28223811	Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and <i>COMT</i> gene.	Tang X et al.	2017	Neuropsychiatric disease and treatment
28235603	Val158Met polymorphism in the COMT gene is associated with hypersomnia and mental health-related quality of life in a Colombian sample.	Jiménez KM et al.	2017	Neuroscience letters
28253266	Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis.	Wu X et al.	2017	PloS one
28259860	Potential salivary biomarkers and their genetic effects in a pilot study of adolescent boys with externalizing problems.	Angyal N et al.	2016	Neuropsychopharmacologia Hungarica
28273278	Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls.	Matsuzaka CT et al.	2017	Revista brasileira de psiquiatria (Sao Paulo, Brazil
28321040	Whole exome sequencing detects variants of genes that mediate response to anticancer drugs.	Ohnami S et al.	2017	The Journal of toxicological sciences
28388928	SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature.	Bokharaeian B et al.	2017	Journal of biomedical semantics
28399184	Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease.	Huertas I et al.	2017	PloS one
28429405	Child body mass index, genotype and parenting in the prediction of restrictive feeding.	Bost KK et al.	2018	Pediatric obesity
28446500	Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylation.	De la Torre R et al.	2017	The American journal of clinical nutrition
28451382	Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson's disease.	Xiao Q et al.	2017	Translational neurodegeneration
28452825	Joint Impact of Early Life Adversity and COMT Val158Met (rs4680) Genotypes on the Adult Cortisol Response to Psychological Stress.	Lovallo WR et al.	2017	Psychosomatic medicine
28462386	Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury.	Randesi M et al.	2017	Cellular and molecular gastroenterology and hepatology
28472995	Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men.	Ou WC et al.	2017	Behavioral and brain functions
28533660	Genes, emotions and gut microbiota: The next frontier for the gastroenterologist.	Panduro A et al.	2017	World journal of gastroenterology
28534260	Pharmacogenetics of Cannabinoids.	Hryhorowicz S et al.	2018	European journal of drug metabolism and pharmacokinetics
28582665	The influence of CHRNA4, COMT, and maternal sensitivity on orienting and executive attention in 6-month-old infants.	Quan J et al.	2017	Brain and cognition
28610409	Impact of Catechol-O-Methyltransferase Val 158Met (rs4680) Polymorphism on Breast Cancer Susceptibility in Asian Population	Rai V et al.	2017	Asian Pacific journal of cancer prevention
28614354	Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD.	O'Donnell KJ et al.	2017	PloS one
28627776	The Catechol-O-methyltransferase Val(108/158)Met Genetic Polymorphism cannot be Recommended as a Biomarker for the Prediction of Venlafaxine Efficacy in Patients Treated in Psychiatric Settings.	Taranu A et al.	2017	Basic & clinical pharmacology & toxicology
28629779	Are dopaminergic genotypes risk factors for eating behavior and obesity in adults?	Avsar O et al.	2017	Neuroscience letters
28635556	Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders.	Carrà G et al.	2017	Nordic journal of psychiatry
28648906	COMT genotype is differentially associated with single trial variability of ERPs as a function of memory type.	Rostami HN et al.	2017	Biological psychology
28656735	An analysis of genetic association in opioid dependence susceptibility.	Nagaya D et al.	2018	Journal of clinical pharmacy and therapeutics
28665765	The association between COMT rs4680 and 5-HTTLPR genotypes and concussion history in South African rugby union players.	Mc Fie S et al.	2018	Journal of sports sciences
28694222	Effects of single genetic variants and polygenic obesity risk scores on disordered eating in adolescents - The HUNT study.	Sardahaee FS et al.	2017	Appetite
28707072	Catechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer's Disease.	Chang CC et al.	2018	Molecular neurobiology
28728097	Nonlinear modulation of interacting between COMT and depression on brain function.	Gong L et al.	2017	European psychiatry
28740224	Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson's disease.	Lin CH et al.	2017	Scientific reports
28744152	Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder.	Zastrozhin MS et al.	2017	Pharmacogenomics and personalized medicine
28746172	A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers.	Xu J et al.	2017	Medicine
28822116	Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.	Misiak B et al.	2018	Molecular neurobiology
28844929	Distribution, properties, and inhibitor sensitivity of zebrafish catechol-O-methyl transferases (COMT).	Semenova S et al.	2017	Biochemical pharmacology
28871191	Pharmacogenetics of methylphenidate in childhood attention-deficit/hyperactivity disorder: long-term effects.	Gomez-Sanchez CI et al.	2017	Scientific reports
28887105	The significance of polymorphism and expression of oestrogen metabolism-related genes in Chinese women with premature ovarian insufficiency.	Qin C et al.	2017	Reproductive biomedicine online
28900390	Genetically-Driven Enhancement of Dopaminergic Transmission Affects Moral Acceptability in Females but Not in Males: A Pilot Study.	Pellegrini S et al.	2017	Frontiers in behavioral neuroscience
28927418	A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson's disease.	Guin D et al.	2017	BMC medical genomics
28928973	Prospective replication study implicates the catechol-O-methyltransferase Val<sup>158</sup>Met polymorphism as a biomarker for the response to morphine in patients with cancer.	Matsuoka H et al.	2017	Biomedical reports
28948081	Sex-specific effects of <i>COMT</i> Val158Met polymorphism on corpus callosum structure: A whole-brain diffusion-weighted imaging study.	El-Hage W et al.	2017	Brain and behavior
28968343	Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia.	Forsberg JT et al.	2018	Pain
29020372	Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors.	Bhakta SG et al.	2017	The international journal of neuropsychopharmacology
29048744	Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.	Yeung EW et al.	2017	Alcoholism, clinical and experimental research
29091826	Genotypic and haplotypic associations of catechol-O-methyltransferase (COMT) rs4680 and rs4818 with salivary cortisol in patients with schizophrenia.	Hirasawa-Fujita M et al.	2018	Psychiatry research
29135816	Dopaminergic Genetic Variants and Voluntary Externally Paced Exercise Behavior.	VAN DER Mee DJ et al.	2018	Medicine and science in sports and exercise
29154367	Effects of Amphetamine on Sensorimotor Gating and Neurocognition in Antipsychotic-Medicated Schizophrenia Patients.	Swerdlow NR et al.	2018	Neuropsychopharmacology
29193749	Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years.	Borobia AM et al.	2018	Clinical and translational science
29195501	COMT genotype and non-recovery after a whiplash injury in a Northern European population.	Rydman E et al.	2017	BMC musculoskeletal disorders
29198511	Preliminary Evidence for an Association Between Variants of the Catechol-O-Methyltransferase (COMT) Gene and Premature Ejaculation.	Jern P et al.	2017	The journal of sexual medicine
29201551	Investigation of the <i>COMT</i> Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.	Lodhi RJ et al.	2017	Brain and behavior
29225702	The influence of dopamine-beta-hydroxylase and catechol <i>O</i>-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus.	Bozek T et al.	2017	Diabetology & metabolic syndrome
29230023	Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD.	Myer NM et al.	2018	Molecular psychiatry
29247072	Vascular and dopaminergic contributors to mild parkinsonian signs in older adults.	Rosso AL et al.	2018	Neurology
29249680	Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease.	Miller NS et al.	2018	Parkinsonism & related disorders
29255361	Potential link between genetic polymorphisms of <i>catechol-O-methyltransferase</i> and dopamine receptors and treatment efficacy of risperidone on schizophrenia.	Han J et al.	2017	Neuropsychiatric disease and treatment
29259946	Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment.	Chatti I et al.	2017	Iranian journal of public health
29270116	COMT Val<sup>158</sup>Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function.	Elton A et al.	2017	Frontiers in human neuroscience
29287625	Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response.	Quednow BB et al.	2018	Schizophrenia research
29289372	Childhood Abuse Experiences and the COMT and MTHFR Genetic Variants Associated With Male Sexual Orientation in the Han Chinese Populations: A Case-Control Study.	Qin JB et al.	2018	The journal of sexual medicine
29325115	Fast sleep spindle density is associated with rs4680 (Val108/158Met) genotype of catechol-O-methyltransferase (COMT).	Schilling C et al.	2018	Sleep
29326607	<i>CYP1A1</i> Ile462Val Polymorphism Is Associated with Cervical Cancer Risk in Caucasians Not Asians: A Meta-Analysis.	Wang LN et al.	2017	Frontiers in physiology
29330410	The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.	Bernegger A et al.	2018	Scientific reports
29331705	Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study.	Koike S et al.	2018	Journal of affective disorders
29351172	Systematic review and meta-analysis of genetic risk factors for neuropathic pain.	Veluchamy A et al.	2018	Pain
29368490	Catechol-oxide-methyltransferase (COMT rs4680:G>A) gene polymorphism does not affect analgesics’ demand after elective hip replaceme.	Białecka M et al.	2016	Genetika
29426301	The COMT-polymorphism is not associated with the incidence of acute kidney injury after cardiac surgery - a prospective cohort study.	Oezkur M et al.	2018	BMC nephrology
29429137	COMT and GAD1 gene polymorphisms are associated with impaired antisaccade task performance in schizophrenic patients.	Kirenskaya AV et al.	2018	European archives of psychiatry and clinical neuroscience
29439855	Catechol-O-methyltransferase (COMT) genetic variants are associated with cognitive decline in patients with Parkinson's disease.	Lin CH et al.	2018	Parkinsonism & related disorders
29455339	Analysis of COMT Val158Met polymorphisms and methylation in Chinese male schizophrenia patients with homicidal behavior.	Hu Y et al.	2018	International journal of legal medicine
29474345	Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study.	Aubrun F et al.	2018	European journal of anaesthesiology
29510000	Genetic Variations, Exposure to Persistent Organic Pollutants and Breast Cancer Risk - A Greenlandic Case-Control Study.	Wielsøe M et al.	2018	Basic & clinical pharmacology & toxicology
29550002	Pulp Sensitivity: Influence of Sex, Psychosocial Variables, COMT Gene, and Chronic Facial Pain.	Mladenovic I et al.	2018	Journal of endodontics
29559020	Gene polymorphisms and response to transcranial direct current stimulation for auditory verbal hallucinations in schizophrenia.	Chhabra H et al.	2018	Acta neuropsychiatrica
29559808	Association of genetic variation in <i>COMT</i> gene with pain related to sickle cell disease in patients from the walk-PHaSST study.	Zhang Y et al.	2018	Journal of pain research
29574383	Interplay between COMT Val158Met, childhood adversities and sex in predicting panic pathology: Findings from a general population sample.	Asselmann E et al.	2018	Journal of affective disorders
29578580	MAO-B and COMT Genetic Variations Associated With Levodopa Treatment Response in Patients With Parkinson's Disease.	Sampaio TF et al.	2018	Journal of clinical pharmacology
29634613	Association between COMT gene polymorphisms, clinical symptoms, and cognitive functions in Han Chinese patients with schizophrenia.	Sun Z et al.	2018	Psychiatric genetics
29677196	Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition.	Crum AJ et al.	2018	PloS one
29684863	Psychological and genetic risk factors associated with suicidal behavior in Korean patients with mood disorders.	Choi HY et al.	2018	Journal of affective disorders
29760667	A <i>DRD2/ANNK1</i>-<i>COMT</i> Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese.	Zhang K et al.	2018	Frontiers in psychiatry
29912452	Genetic Predictors of Response to Acupuncture for Aromatase Inhibitor-Associated Arthralgia Among Breast Cancer Survivors.	Genovese TJ et al.	2019	Pain medicine (Malden, Mass.)
29941295	Beneficial and adverse effects of antipsychotic medication on cognitive flexibility are related to COMT genotype in first episode psychosis.	Nelson CLM et al.	2018	Schizophrenia research
29950847	<i>COMT</i> Val 108/158 Met polymorphism and treatment response to aripiprazole in patients with acute schizophrenia.	Kaneko H et al.	2018	Neuropsychiatric disease and treatment
29992684	A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.	Kim J et al.	2018	The American journal on addictions
30011860	Potential Impact of <i>COMT-rs4680 G > A</i> Gene Polymorphism in Coronary Artery Disease.	Mir R et al.	2018	Journal of cardiovascular development and disease
30018555	Haplotypic and Genotypic Association of Catechol-<i>O</i>-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia.	Sagud M et al.	2018	Frontiers in pharmacology
30027496	Dopamine, time perception, and future time perspective.	Mitchell JM et al.	2018	Psychopharmacology
30041166	Temperament and Character Inventory in Bipolar Disorder versus Healthy Controls and Modulatory Effects of 3 Key Functional Gene Variants.	Porcelli S et al.	2017	Neuropsychobiology
30093869	Biological Predictors of Clozapine Response: A Systematic Review.	Samanaite R et al.	2018	Frontiers in psychiatry
30123371	Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.	Zhu W et al.	2018	The open rheumatology journal
30127727	The COMT Val158Met Polymorphism and Reaction to a Transgression: Findings of Genetic Associations in Both Chinese and German Samples.	Sindermann C et al.	2018	Frontiers in behavioral neuroscience
30130297	The opioid receptor mu 1 (OPRM1) rs1799971 and catechol-O-methyltransferase (COMT) rs4680 as genetic markers for placebo analgesia.	Aslaksen PM et al.	2018	Pain
30137607	Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC]).	Park JY et al.	2019	Translational behavioral medicine
30139393	Selective role for the COMT polymorphism in a trans-diagnostic compulsivity phenotype.	Chamberlain SR et al.	2018	Psychological medicine
30178121	Neuroplasticity, Neurotransmission and Brain-Related Genes in Major Depression and Bipolar Disorder: Focus on Treatment Outcomes in an Asiatic Sample.	Calabrò M et al.	2018	Advances in therapy
30211780	Associations of catechol-O-methyltransferase (rs4680) single nucleotide polymorphisms with opioid use and dose among adults with chronic pain.	Hooten WM et al.	2019	Pain
30216543	Functional monoamine oxidase B gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson's disease.	Löhle M et al.	2018	Movement disorders
30218069	Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex.	Parkin GM et al.	2018	Journal of human genetics
30234521	Influences of COMT rs4680 and OPRM1 rs1799971 Polymorphisms on Chronic Postsurgical Pain, Acute Pain, and Analgesic Consumption After Elective Cesarean Delivery.	Wang L et al.	2019	The Clinical journal of pain
30300332	Effects of COMT polymorphism on the cortical processing of vocal pitch regulation.	Zhang S et al.	2018	Neuroreport
30342271	Frontoparietal cortical thickness mediates the effect of COMT Val<sup>158</sup>Met polymorphism on age-associated executive function.	Miranda GG et al.	2019	Neurobiology of aging
30402947	The COMT Val<sup>158</sup> Met polymorphism does not modulate the after-effect of tDCS on working memory.	Jongkees BJ et al.	2019	The European journal of neuroscience
30408108	Vulnerable combinations of functional dopaminergic polymorphisms to late-onset treatment resistant schizophrenia.	Oishi K et al.	2018	PloS one
30424994	The Association Between C-Reactive Protein and Postoperative Delirium Differs by Catechol-O-Methyltransferase Genotype.	Vasunilashorn SM et al.	2019	The American journal of geriatric psychiatry
30461653	Association between polymorphisms in estrogen metabolism genes and breast cancer development in Chinese women: A prospective case-control study.	Qiu J et al.	2018	Medicine
30481348	Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine.	Fernández-de-Las-Peñas C et al.	2019	Pain medicine (Malden, Mass.)
30486733	Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers.	D'Agnelli S et al.	2019	Molecular pain
30592275	Pain polymorphisms and opioids: An evidence based review.	Vieira CMP et al.	2019	Molecular medicine reports
30597299	A gender-specific COMT haplotype contributes to risk modulation rather than disease severity of major depressive disorder in a Chinese population.	Chao JK et al.	2019	Journal of affective disorders
30608422	Analysis of the relationship between COMT polymorphisms and endometriosis susceptibility.	Zhai J et al.	2019	Medicine
30614828	Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache.	Fernández-de-Las-Peñas C et al.	2019	The Clinical journal of pain
30624689	COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials.	Hall KT et al.	2019	Journal of the National Cancer Institute
30628551	The influence of Val158Met COMT on physiological stress responsivity.	Serrano JM et al.	2019	Stress (Amsterdam, Netherlands)
30704436	Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review.	Lucenteforte E et al.	2019	BMC cancer
30709768	Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18 months.	Chau CMY et al.	2019	EBioMedicine
30719257	Genetic Variations of <i>DAOA</i> (rs947267 and rs3918342) and <i>COMT</i> Genes (rs165599 and rs4680) in Schizophrenia and Bipolar I Disorder.	Ahmadi L et al.	2018	Basic and clinical neuroscience
30742958	Both Val158Met Polymorphism of Catechol-O-Methyltransferase Gene and Menstrual Cycle Affect Prepulse Inhibition but Not Attentional Modulation of Prepulse Inhibition in Younger-Adult Females.	Wu C et al.	2019	Neuroscience
30790653	Usefulness of COMT gene polymorphisms in North African populations.	Boussetta S et al.	2019	Gene
30822160	Association of COMT gene variability with pain intensity in patients after total hip replacement.	Machoy-Mokrzyńska A et al.	2019	Scandinavian journal of clinical and laboratory investigation
30840133	Association of GA genotype of SNP rs4680 in COMT gene with psoriasis.	Sobolev V et al.	2019	Archives of dermatological research
30852803	Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms.	Cui L et al.	2019	Neuroscience bulletin
30886988	Association of Catechol-<i>O</i>-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients.	Lee C et al.	2018	BMC rheumatology
30887472	[The Association between the Extended Psychosis Phenotype and COMT val158met and BDNF val66met polymorphisms].	Binbay T et al.	2018	Turk psikiyatri dergisi = Turkish journal of psychiatry
30909076	BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy.	Doherty C et al.	2019	Epilepsy & behavior
30954919	Age-specific associations among functional COMT Val<sup>158</sup>Met polymorphism, resting parasympathetic nervous control and generalized anxiety disorder.	Chang HA et al.	2019	Psychoneuroendocrinology
30985623
31023072	Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms.	Knisely MR et al.	2019	Biological research for nursing
31041874	Effect of catechol-O-methyltransferase (rs4680) single-nucleotide polymorphism on opioid-induced hyperalgesia in adults with chronic pain.	Hooten WM et al.	2019	Molecular pain
31072614	The lack of association between COMT rs4680 polymorphism and symptomatic remission to olanzapine monotherapy in male schizophrenic patients: A longitudinal study.	Zivkovic M et al.	2019	Psychiatry research
31085105	Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management.	Yang GS et al.	2019	Seminars in oncology nursing
31096213	Alzheimer's Disease and Neurotransmission Gene Variants: Focus on Their Effects on Psychiatric Comorbidities and Inflammatory Parameters.	Porcelli S et al.	2019	Neuropsychobiology
31129315	Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain.	Chidambaran V et al.	2020	The journal of pain
31137904	Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity.	Crocco P et al.	2019	Genes
31142902	Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders.	Cengiz M et al.	2019	Indian journal of psychiatry
31150143	Early-Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes.	Lovallo WR et al.	2019	Alcoholism, clinical and experimental research
31159911	Problematic internet use: an exploration of associations between cognition and COMT rs4818, rs4680 haplotypes.	Ioannidis K et al.	2020	CNS spectrums
31187152	Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans.	Ranganathan M et al.	2019	Psychopharmacology
31192519	Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation.	Moses TEH et al.	2020	Addiction biology
31224505
31239688	COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder.	Otsuka Y et al.	2019	Neuropsychiatric disease and treatment
31269327	Genetic Contribution in Low Back Pain: A Prospective Genetic Association Study.	Margarit C et al.	2019	Pain practice
31289926	Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians.	Avinun R et al.	2020	European archives of psychiatry and clinical neuroscience
31291232	The Association of Catechol-O-Methyl-Transferase and Interleukin 6 Gene Polymorphisms with Posttraumatic Stress Disorder.	Haxhibeqiri V et al.	2019	Psychiatria Danubina
31303260	Which Dopamine Polymorphisms Are Functional? Systematic Review and Meta-analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1, and VMAT2.	Tunbridge EM et al.	2019	Biological psychiatry
31335650	OPRM1 rs1799971, COMT rs4680, and FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia.	Colloca L et al.	2019	Pain
31372986	Relations between catechol-O-methyltransferase Val158Met genotype and inhibitory control development in childhood.	Bowers ME et al.	2020	Developmental psychobiology
31493434	Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone.	Jones JD et al.	2019	Pharmacology, biochemistry, and behavior
31552390	Placebo effects and the molecular biological components involved.	Cai L et al.	2019	General psychiatry
31555452	<i>BDNF</i>, <i>COMT</i>, and <i>DRD2</i> polymorphisms and ability to return to work in adult patients with low- and high-grade glioma.	Altshuler DB et al.	2019	Neuro-oncology practice
31559529	Influence of dopamine-related genes on craving, impulsivity, and aggressiveness in Korean males with alcohol use disorder.	Park CI et al.	2021	European archives of psychiatry and clinical neuroscience
31586564	The potential impact of COMT gene variants on dopamine regulation and phenotypic traits of ASD patients.	Esmaiel NN et al.	2020	Behavioural brain research
31661578	Effects of genotype on TENS effectiveness in controlling knee pain in persons with mild to moderate osteoarthritis.	Govil M et al.	2020	European journal of pain (London, England)
31673237	Association study of the functional Catechol-O-Methyltranferase (COMT) Val<sup>158</sup>Met polymorphism on executive cognitive function in a Thai sample.	Khanthiyong B et al.	2019	International journal of medical sciences
31721892	Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial.	Brunoni AR et al.	2020	Revista brasileira de psiquiatria (Sao Paulo, Brazil
31744450	Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine.	Abijo T et al.	2020	Current neuropharmacology
31771069	Relationships of Cerebrospinal Fluid Alzheimer's Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms.	Babić Leko M et al.	2020	Journal of Alzheimer's disease
31798476	Association of rs4680 <i>COMT</i>, rs6280 <i>DRD3</i>, and rs7322347 <i>5HT2A</i> With Clinical Features of Youth-Onset Schizophrenia.	Morozova A et al.	2019	Frontiers in psychiatry
31806881	OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study.	Ho KWD et al.	2020	The pharmacogenomics journal
31838976	Catechol-O-Methyltransferase and Cardiovascular Disease: MESA.	Hall KT et al.	2019	Journal of the American Heart Association
31874497	[Effect of opioid-related gene polymorphisms on patients with high-dose opioid-tolerant cancer pain].	Xie GL et al.	2019	Zhonghua yi xue za zhi
31879835	Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis.	Kumar P et al.	2020	Metabolic brain disease
31889426	Effects of traumatic life events, cognitive biases and variation in dopaminergic genes on psychosis proneness.	Kotowicz K et al.	2021	Early intervention in psychiatry
31917897	Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training-related prefrontal plasticity.	Zhao W et al.	2020	Brain and behavior
31960101	Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex.	Dean B et al.	2020	Experimental brain research
31972309	Association between COMT gene Val108/158Met and antidepressive treatment response: A meta-analysis.	Tang Z et al.	2020	Gene
32022467	Gene polymorphisms and motor levodopa-induced complications in Parkinson's disease.	Michałowska M et al.	2020	Brain and behavior
32024434	COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity.	Xu F et al.	2020	Molecular pain
32034175	COMT-Polymorphisms Modulated Functional Profile of the Fusiform Face Area Contributes to Face-Specific Recognition Ability.	Wu C et al.	2020	Scientific reports
32057830	Interaction of COMT and KIBRA modulates the association between hippocampal structure and episodic memory performance in healthy young adults.	Wang J et al.	2020	Behavioural brain research
32066722	Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child.	Qi R et al.	2020	Translational psychiatry
32071497	Evaluation of COMT Gene rs4680 Polymorphism as a Risk Factor for Endometrial Cancer.	Kumar P et al.	2020	Indian journal of clinical biochemistry
32079998	Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain.	Baumbauer KM et al.	2020	The Clinical journal of pain
32132825	The "Warrior" COMT Val/Met Genotype Occurs in Greater Frequencies in Mixed Martial Arts Fighters Relative to Controls.	Tartar JL et al.	2020	Journal of sports science & medicine
32149782	Sex Bias and Genotype Influence on Opioid Safety Profile in Chronic Low Back Pain.	Margarit C et al.	2020	The Clinical journal of pain
32185238	Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia.	Chen A et al.	2020	Journal of immunology research
32230800	Influence of Genetic Variation in <i>COMT</i> on Cisplatin-Induced Nephrotoxicity in Cancer Patients.	Agema BC et al.	2020	Genes
32265697	Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia.	Cao M et al.	2020	Frontiers in pharmacology
32306439	The influence of COMT rs4680 on functional connectivity in healthy adults: A systematic review.	Morris KA et al.	2020	The European journal of neuroscience
32326111	Role of Genetic Variations in the Hepatic Handling of Drugs.	Marin JJG et al.	2020	International journal of molecular sciences
32367059	Genetic basis of sleep bruxism and sleep apnea-response to a medical puzzle.	Wieckiewicz M et al.	2020	Scientific reports
32398646	Do AKT1, COMT and FAAH influence reports of acute cannabis intoxication experiences in patients with first episode psychosis, controls and young adult cannabis users?	Hindocha C et al.	2020	Translational psychiatry
32407152	Association of <i>COMT</i> Gene Polymorphisms with Response to Methadone Maintenance Treatment Among Chinese Opioid-Dependent Patients.	Duan L et al.	2020	Genetic testing and molecular biomarkers
32433545	Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia.	Tao R et al.	2020	Translational psychiatry
32457675	After the Honeymoon: Neural and Genetic Correlates of Romantic Love in Newlywed Marriages.	Acevedo BP et al.	2020	Frontiers in psychology
32461926	Genotyping on blood and buccal cells using loop-mediated isothermal amplification in healthy humans.	Drogou C et al.	2020	Biotechnology reports (Amsterdam, Netherlands)
32483134	The atorvastatin metabolic phenotype shift is influenced by interaction of drug-transporter polymorphisms in Mexican population: results of a randomized trial.	León-Cachón RBR et al.	2020	Scientific reports
32525059	Genetic underpinnings of schizophrenia-related electroencephalographical intermediate phenotypes: A systematic review and meta-analysis.	Hederih J et al.	2021	Progress in neuro-psychopharmacology & biological psychiatry
32533012	Genetic variations in catechol-O-methyltransferase gene are associated with levodopa response variability in Chinese patients with Parkinson's disease.	Zhao C et al.	2020	Scientific reports
32572118	Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia.	Nikolac Perkovic M et al.	2020	Scientific reports
32576619	Effects of <i>TPH2</i> gene variation and childhood trauma on the clinical and circuit-level phenotype of functional movement disorders.	Spagnolo PA et al.	2020	Journal of neurology, neurosurgery, and psychiatry
32618128	Interaction between catechol-O-methyltransferase polymorphism and childhood trauma in suicidal ideation of patients with post-traumatic stress disorder.	Kwon A et al.	2020	Brain and behavior
32623490	Genetic risks of schizophrenia identified in a matched case-control study.	Oishi K et al.	2021	European archives of psychiatry and clinical neuroscience
32662357	Evaluation of COMT (rs4680), CNR2 (rs2501432), CNR2 (rs2229579), UCP2 (rs659366), and IL-17 (rs763780) gene variants in synthetic cannabinoid use disorder patients.	Pehlivan S et al.	2020	Journal of addictive diseases
32692209	No association between the COMT Val158Met polymorphism and cognitive training response in healthy Shanghai community-dwelling elderly individuals.	Feng W et al.	2020	Annals of palliative medicine
32723321	The association between serotonin-related gene polymorphisms and susceptibility and early sertraline response in patients with panic disorder.	Zou Z et al.	2020	BMC psychiatry
32744066	A meta-analysis and <i>in silico</i> analysis of polymorphic variants conferring breast cancer risk in the Indian subcontinent.	Sengupta D et al.	2020	Future oncology (London, England)
32772383	Opioid and Dopamine Genes Interact to Predict Naltrexone Response in a Randomized Alcohol Use Disorder Clinical Trial.	Anton RF et al.	2020	Alcoholism, clinical and experimental research
32782694	The association of catechol-O-methyltransferase (COMT) rs4680 polymorphisms and generalized anxiety disorder in the Chinese Han population.	He Q et al.	2020	International journal of clinical and experimental pathology
32822765	The role of COMT polymorphism in modulation of prefrontal activity during verbal fluency in bipolar disorder.	Devrimci-Ozguven H et al.	2020	Neuroscience letters
32828797	Lack of association of common polymorphisms linked to empathic behavior with self-reported trait empathy in healthy volunteers.	Huetter FK et al.	2020	Hormones and behavior
32829984	Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives.	Hochberger WC et al.	2020	Schizophrenia research
32879833	Warriors, Worriers, and COVID-19: An Exploratory Study of the Catechol O-Methyltransferase Val158Met Polymorphism Across Populations.	Rajkumar RP et al.	2020	Cureus
32889058	Epistatic effect of Ankyrin repeat and kinase domain containing 1 - Dopamine receptor D2 and catechol-o-methyltransferase single nucleotide polymorphisms on the risk for hazardous use of alcohol in Lithuanian population.	Kaminskaite M et al.	2021	Gene
32931693	The effect of rs1076560 (DRD2) and rs4680 (COMT) on tardive dyskinesia and cognition in schizophrenia subjects.	Punchaichira TJ et al.	2020	Psychiatric genetics
32974928	The COMT rs4680 polymorphism, family functioning and preschoolers' attentional control indexed by intraindividual reaction time variability.	Zhang Y et al.	2021	Developmental psychobiology
32976278	Correlation Between the Warrior/Worrier Gene on Post Burn Pruritus and Scarring: A Prospective Cohort Study.	Oh J et al.	2022	Annals of surgery
32985495	Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression.	Li W et al.	2020	Medical science monitor
33013295	Contribution of Five Functional Loci of Dopamine Metabolism-Related Genes to Parkinson's Disease and Multiple System Atrophy in a Chinese Population.	Chen Y et al.	2020	Frontiers in neuroscience
33040669	Genetics of human startle reactivity: A systematic review to acquire targets for an anxiety endophenotype.	Tomasi J et al.	2021	The world journal of biological psychiatry
33043988	Catechol-O-Methyltransferase Genotype, Frailty, and Gait Speed in a Biracial Cohort of Older Adults.	Mance S et al.	2021	Journal of the American Geriatrics Society
33093598	Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism.	Senek M et al.	2020	Scientific reports
33100205	Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis.	Ma J et al.	2021	Current neuropharmacology
33108341	The association between selected genetic variants and individual differences in experimental pain.	Lie MU et al.	2021	Scandinavian journal of pain
33127070	The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia.	Wang J et al.	2021	Journal of psychiatric research
33154520	A review of the existing literature on buprenorphine pharmacogenomics.	Meaden CW et al.	2021	The pharmacogenomics journal
33250838	Polymorphism of the Dopa-Decarboxylase Gene Modifies the Motor Response to Levodopa in Chinese Patients With Parkinson's Disease.	Li L et al.	2020	Frontiers in neurology
33262486	Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters.		2020	European journal of human genetics
33263843	Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study).	Ivanova TI et al.	2020	Bulletin of experimental biology and medicine
33278020	Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics.	Koller D et al.	2021	Advances in therapy
33282008	Lack of Association between rs4680 Polymorphism in Catechol-O-Methyltransferase Gene and Alcohol Use Disorder: A Meta-Analysis.	Jin XR et al.	2020	Disease markers
33303340	OXTR rs53576 Variation with Breast and Nipple Pain in Breastfeeding Women.	Lucas R et al.	2021	Pain management nursing
33324248	Genetic Determinants of Gating Functions: Do We Get Closer to Understanding Schizophrenia Etiopathogenesis?	Rovný R et al.	2020	Frontiers in psychiatry
33360592	Fluoride exposure, dopamine relative gene polymorphism and intelligence: A cross-sectional study in China.	Zhao L et al.	2021	Ecotoxicology and environmental safety
33450700	The COMT gene rs4680 polymorphism moderates the relationship between adult ADHD symptoms and executive dysfunction.	Liu J et al.	2021	Asian journal of psychiatry
33451866	Influence of ADRB1, ADRB2, and COMT Genetic Polymorphisms on Postoperative Outcomes of Patients Undergoing Cardiac Valve Surgery.	Dai S et al.	2021	Clinical therapeutics
33453563	Association between COMT methylation and response to treatment in children with ADHD.	Fageera W et al.	2021	Journal of psychiatric research
33561612	Genetic variants in levodopa-induced dyskinesia (LID): A systematic review and meta-analysis.	Falla M et al.	2021	Parkinsonism & related disorders
33588721	Risk Genes in Schizophrenia and Their Importance in Choosing the Appropriate Antipsychotic Treatment.	Werner FM et al.	2021	Current pharmaceutical design
33632172	Discovery of breast cancer risk genes and establishment of a prediction model based on estrogen metabolism regulation.	Zhao F et al.	2021	BMC cancer
33666309	No links between genetic variation and developing theory of mind: A preregistered replication attempt of candidate gene studies.	Opitz T et al.	2021	Developmental science
33716034	Genetic Predictors of Response to Acupuncture or Cognitive Behavioral Therapy for Insomnia in Cancer Survivors: An Exploratory Analysis.	Genovese TJ et al.	2021	Journal of pain and symptom management

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

Select flank length:

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Choose placement

dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs4680