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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.


Current Build 155

Released April 9, 2021

Homo sapiens
chr22:19963748 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Variation Type
SNV Single Nucleotide Variation
A=0.489085 (138095/282354, ALFA)
A=0.420394 (111274/264690, TOPMED)
A=0.461091 (114049/247346, GnomAD_exome) (+ 25 more)
A=0.440445 (61679/140038, GnomAD)
A=0.472746 (55317/117012, ExAC)
A=0.34951 (27472/78602, PAGE_STUDY)
A=0.31730 (5318/16760, 8.3KJPN)
A=0.3692 (1849/5008, 1000G)
G=0.4507 (2019/4480, Estonian)
G=0.4878 (1880/3854, ALSPAC)
G=0.4984 (1848/3708, TWINSUK)
A=0.3926 (1280/3260, PRJNA289433)
G=0.4993 (1471/2946, PharmGKB)
A=0.2850 (835/2930, KOREAN)
A=0.3781 (788/2084, HGDP_Stanford)
A=0.3513 (664/1890, HapMap)
A=0.2686 (492/1832, Korea1K)
G=0.483 (482/998, GoNL)
A=0.241 (183/760, PRJEB37584)
A=0.254 (156/614, Vietnamese)
G=0.462 (277/600, NorthernSweden)
A=0.436 (233/534, MGP)
G=0.349 (123/352, SGDP_PRJ)
G=0.459 (134/292, FINRISK)
G=0.458 (99/216, Qatari)
A=0.47 (40/86, Ancient Sardinia)
G=0.31 (13/42, Siberian)
G=0.28 (11/40, GENOME_DK)
Clinical Significance
Reported in ClinVar
Gene : Consequence
COMT : Missense Variant
MIR4761 : 2KB Upstream Variant
791 citations
Genomic View
See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 282354 G=0.510915 A=0.489085
European Sub 233224 G=0.491982 A=0.508018
African Sub 11528 G=0.69240 A=0.30760
African Others Sub 370 G=0.735 A=0.265
African American Sub 11158 G=0.69098 A=0.30902
Asian Sub 3820 G=0.7351 A=0.2649
East Asian Sub 2420 G=0.7231 A=0.2769
Other Asian Sub 1400 G=0.7557 A=0.2443
Latin American 1 Sub 976 G=0.571 A=0.429
Latin American 2 Sub 8888 G=0.5842 A=0.4158
South Asian Sub 5060 G=0.5496 A=0.4504
Other Sub 18858 G=0.54073 A=0.45927


Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 G=0.579606 A=0.420394
gnomAD - Exomes Global Study-wide 247346 G=0.538909 A=0.461091
gnomAD - Exomes European Sub 131988 G=0.475430 A=0.524570
gnomAD - Exomes Asian Sub 48836 G=0.62306 A=0.37694
gnomAD - Exomes American Sub 34390 G=0.59520 A=0.40480
gnomAD - Exomes African Sub 16062 G=0.68920 A=0.31080
gnomAD - Exomes Ashkenazi Jewish Sub 10002 G=0.53889 A=0.46111
gnomAD - Exomes Other Sub 6068 G=0.5255 A=0.4745
gnomAD - Genomes Global Study-wide 140038 G=0.559555 A=0.440445
gnomAD - Genomes European Sub 75840 G=0.47466 A=0.52534
gnomAD - Genomes African Sub 41954 G=0.68883 A=0.31117
gnomAD - Genomes American Sub 13648 G=0.59137 A=0.40863
gnomAD - Genomes Ashkenazi Jewish Sub 3318 G=0.5524 A=0.4476
gnomAD - Genomes East Asian Sub 3128 G=0.7324 A=0.2676
gnomAD - Genomes Other Sub 2150 G=0.5893 A=0.4107
ExAC Global Study-wide 117012 G=0.527254 A=0.472746
ExAC Europe Sub 70538 G=0.46782 A=0.53218
ExAC Asian Sub 24544 G=0.60720 A=0.39280
ExAC American Sub 11212 G=0.59249 A=0.40751
ExAC African Sub 9850 G=0.6803 A=0.3197
ExAC Other Sub 868 G=0.517 A=0.483
The PAGE Study Global Study-wide 78602 G=0.65049 A=0.34951
The PAGE Study AfricanAmerican Sub 32444 G=0.68444 A=0.31556
The PAGE Study Mexican Sub 10808 G=0.59354 A=0.40646
The PAGE Study Asian Sub 8304 G=0.6856 A=0.3144
The PAGE Study PuertoRican Sub 7912 G=0.6030 A=0.3970
The PAGE Study NativeHawaiian Sub 4532 G=0.7321 A=0.2679
The PAGE Study Cuban Sub 4230 G=0.5929 A=0.4071
The PAGE Study Dominican Sub 3828 G=0.6196 A=0.3804
The PAGE Study CentralAmerican Sub 2450 G=0.5878 A=0.4122
The PAGE Study SouthAmerican Sub 1980 G=0.6045 A=0.3955
The PAGE Study NativeAmerican Sub 1258 G=0.5676 A=0.4324
The PAGE Study SouthAsian Sub 856 G=0.579 A=0.421
8.3KJPN JAPANESE Study-wide 16760 G=0.68270 A=0.31730
1000Genomes Global Study-wide 5008 G=0.6308 A=0.3692
1000Genomes African Sub 1322 G=0.7194 A=0.2806
1000Genomes East Asian Sub 1008 G=0.7202 A=0.2798
1000Genomes Europe Sub 1006 G=0.5000 A=0.5000
1000Genomes South Asian Sub 978 G=0.559 A=0.441
1000Genomes American Sub 694 G=0.622 A=0.378
Genetic variation in the Estonian population Estonian Study-wide 4480 G=0.4507 A=0.5493
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 G=0.4878 A=0.5122
UK 10K study - Twins TWIN COHORT Study-wide 3708 G=0.4984 A=0.5016
MxGDAR/Encodat-PGx Global Study-wide 3260 G=0.6074 A=0.3926
MxGDAR/Encodat-PGx MxGDAR Sub 3260 G=0.6074 A=0.3926
PharmGKB Aggregated Global Study-wide 2946 G=0.4993 A=0.5007
PharmGKB Aggregated PA156007059 Sub 2352 G=0.4613 A=0.5387
PharmGKB Aggregated PA150018199 Sub 354 G=0.658 A=0.342
PharmGKB Aggregated PA137869186 Sub 240 G=0.637 A=0.362
KOREAN population from KRGDB KOREAN Study-wide 2930 G=0.7150 A=0.2850
HGDP-CEPH-db Supplement 1 Global Study-wide 2084 G=0.6219 A=0.3781
HGDP-CEPH-db Supplement 1 Est_Asia Sub 470 G=0.743 A=0.257
HGDP-CEPH-db Supplement 1 Central_South_Asia Sub 414 G=0.527 A=0.473
HGDP-CEPH-db Supplement 1 Middle_Est Sub 350 G=0.523 A=0.477
HGDP-CEPH-db Supplement 1 Europe Sub 320 G=0.512 A=0.487
HGDP-CEPH-db Supplement 1 Africa Sub 242 G=0.744 A=0.256
HGDP-CEPH-db Supplement 1 America Sub 216 G=0.713 A=0.287
HGDP-CEPH-db Supplement 1 Oceania Sub 72 G=0.67 A=0.33
HapMap Global Study-wide 1890 G=0.6487 A=0.3513
HapMap American Sub 770 G=0.613 A=0.387
HapMap African Sub 690 G=0.701 A=0.299
HapMap Asian Sub 254 G=0.689 A=0.311
HapMap Europe Sub 176 G=0.540 A=0.460
Korean Genome Project KOREAN Study-wide 1832 G=0.7314 A=0.2686
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 G=0.483 A=0.517
CNV burdens in cranial meningiomas Global Study-wide 760 G=0.759 A=0.241
CNV burdens in cranial meningiomas CRM Sub 760 G=0.759 A=0.241
A Vietnamese Genetic Variation Database Global Study-wide 614 G=0.746 A=0.254
Northern Sweden ACPOP Study-wide 600 G=0.462 A=0.538
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 G=0.564 A=0.436
SGDP_PRJ Global Study-wide 352 G=0.349 A=0.651
FINRISK Finnish from FINRISK project Study-wide 292 G=0.459 A=0.541
Qatari Global Study-wide 216 G=0.458 A=0.542
Ancient Sardinia genome-wide 1240k capture data generation and analysis Global Study-wide 86 G=0.53 A=0.47
Siberian Global Study-wide 42 G=0.31 A=0.69
The Danish reference pan genome Danish Study-wide 40 G=0.28 A=0.72

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 22 NC_000022.11:g.19963748G>A
GRCh37.p13 chr 22 NC_000022.10:g.19951271G>A
COMT RefSeqGene (LRG_1010) NG_011526.1:g.27009G>A
Gene: COMT, catechol-O-methyltransferase (plus strand)
Molecule type Change Amino acid[Codon] SO Term
COMT transcript variant 3 NM_001135162.2:c.472G>A V [GTG] > M [ATG] Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT NP_001128634.1:p.Val158Met V (Val) > M (Met) Missense Variant
COMT transcript variant 2 NM_001135161.2:c.472G>A V [GTG] > M [ATG] Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT NP_001128633.1:p.Val158Met V (Val) > M (Met) Missense Variant
COMT transcript variant 5 NM_001362828.2:c.472G>A V [GTG] > M [ATG] Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT NP_001349757.1:p.Val158Met V (Val) > M (Met) Missense Variant
COMT transcript variant 4 NM_007310.3:c.322G>A V [GTG] > M [ATG] Coding Sequence Variant
catechol O-methyltransferase isoform S-COMT NP_009294.1:p.Val108Met V (Val) > M (Met) Missense Variant
COMT transcript variant 1 NM_000754.4:c.472G>A V [GTG] > M [ATG] Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT NP_000745.1:p.Val158Met V (Val) > M (Met) Missense Variant
Gene: MIR4761, microRNA 4761 (plus strand) : 2KB Upstream Variant
Molecule type Change Amino acid[Codon] SO Term
MIR4761 transcript NR_039918.1:n. N/A Upstream Transcript Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: A (allele ID: 32630 )
ClinVar Accession Disease Names Clinical Significance
RCV000211145.1 nicotine response - Efficacy Drug-Response
RCV000244083.1 not specified Benign
RCV000786523.1 tramadol response - Dosage, Efficacy Drug-Response
RCV000786728.1 methadone response - Dosage, Efficacy Drug-Response
RCV000786729.1 morphine response - Dosage, Efficacy Drug-Response
RCV000786730.1 opioids response - Dosage, Efficacy Drug-Response
RCV000786731.1 oxycodone response - Dosage, Efficacy Drug-Response
RCV000786732.1 remifentanil response - Dosage, Efficacy Drug-Response
RCV000786733.1 sufentanil response - Dosage, Efficacy Drug-Response
RCV001028880.1 Tramadol response Drug-Response

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement G= A
GRCh38.p13 chr 22 NC_000022.11:g.19963748= NC_000022.11:g.19963748G>A
GRCh37.p13 chr 22 NC_000022.10:g.19951271= NC_000022.10:g.19951271G>A
COMT RefSeqGene (LRG_1010) NG_011526.1:g.27009= NG_011526.1:g.27009G>A
COMT transcript variant 1 NM_000754.4:c.472= NM_000754.4:c.472G>A
COMT transcript variant 1 NM_000754.3:c.472= NM_000754.3:c.472G>A
COMT transcript variant 4 NM_007310.3:c.322= NM_007310.3:c.322G>A
COMT transcript variant 4 NM_007310.2:c.322= NM_007310.2:c.322G>A
COMT transcript variant 5 NM_001362828.2:c.472= NM_001362828.2:c.472G>A
COMT transcript variant 5 NM_001362828.1:c.472= NM_001362828.1:c.472G>A
COMT transcript variant 2 NM_001135161.2:c.472= NM_001135161.2:c.472G>A
COMT transcript variant 2 NM_001135161.1:c.472= NM_001135161.1:c.472G>A
COMT transcript variant 3 NM_001135162.2:c.472= NM_001135162.2:c.472G>A
COMT transcript variant 3 NM_001135162.1:c.472= NM_001135162.1:c.472G>A
catechol O-methyltransferase isoform MB-COMT NP_000745.1:p.Val158= NP_000745.1:p.Val158Met
catechol O-methyltransferase isoform S-COMT NP_009294.1:p.Val108= NP_009294.1:p.Val108Met
catechol O-methyltransferase isoform MB-COMT NP_001349757.1:p.Val158= NP_001349757.1:p.Val158Met
catechol O-methyltransferase isoform MB-COMT NP_001128633.1:p.Val158= NP_001128633.1:p.Val158Met
catechol O-methyltransferase isoform MB-COMT NP_001128634.1:p.Val158= NP_001128634.1:p.Val158Met

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

195 SubSNP, 28 Frequency, 11 ClinVar submissions
No Submitter Submission ID Date (Build)
1 DEBNICK ss5363 Sep 19, 2000 (52)
2 CGAP-GAI ss10902 Sep 19, 2000 (52)
3 KWOK ss232568 Jul 12, 2000 (109)
4 SC ss458935 Jul 12, 2000 (109)
5 SC_JCM ss593353 Jul 16, 2000 (109)
6 UWGC ss869771 Oct 04, 2000 (109)
7 KWOK ss1058120 Oct 04, 2000 (109)
8 LEE ss1525135 Oct 13, 2000 (102)
9 KWOK ss1750406 Oct 18, 2000 (109)
10 HGBASE ss2419858 Nov 14, 2000 (109)
11 AFFX ss2982266 Jun 15, 2001 (102)
12 LEE ss4394550 May 29, 2002 (109)
13 LEE ss4415842 May 29, 2002 (108)
14 YUSUKE ss4933092 Aug 28, 2002 (109)
15 SNP500CANCER ss5586357 Mar 31, 2003 (113)
16 RIKENSNPRC ss6311517 Feb 20, 2003 (111)
17 KIDDLAB ss6312623 Feb 20, 2003 (111)
18 HG_BONN_CNS_SNPS ss12586777 Aug 26, 2003 (117)
19 EGP_SNPS ss12673767 Dec 05, 2003 (119)
20 CGAP-GAI ss16240705 Feb 28, 2004 (126)
21 SSAHASNP ss21854500 Apr 05, 2004 (121)
22 IMCJ-GDT ss22886949 Apr 05, 2004 (121)
23 PERLEGEN ss24702135 Sep 20, 2004 (123)
24 MGC_GENOME_DIFF ss28503610 Sep 24, 2004 (126)
25 MGC_GENOME_DIFF ss28504308 Sep 24, 2004 (126)
26 ABI ss35031502 May 24, 2005 (125)
27 ABI ss41527572 Mar 11, 2006 (126)
28 APPLERA_GI ss48429990 Mar 11, 2006 (126)
29 ILLUMINA ss65728351 Oct 15, 2006 (127)
30 KRIBB_YJKIM ss65824277 Nov 30, 2006 (127)
31 ILLUMINA ss66561034 Nov 30, 2006 (127)
32 EGP_SNPS ss66862091 Nov 30, 2006 (127)
33 ILLUMINA ss67358029 Nov 30, 2006 (127)
34 ILLUMINA ss67746210 Nov 30, 2006 (127)
35 PERLEGEN ss69277073 May 17, 2007 (127)
36 PHARMGKB_PPII ss69367705 May 17, 2007 (127)
37 ILLUMINA ss70815561 May 24, 2008 (130)
38 ILLUMINA ss71396394 May 17, 2007 (127)
39 ILLUMINA ss75741500 Dec 07, 2007 (129)
40 AFFY ss76724792 Dec 07, 2007 (129)
41 SI_EXO ss76883807 Dec 07, 2007 (129)
42 ILLUMINA ss79189355 Dec 14, 2007 (130)
43 KRIBB_YJKIM ss83346610 Dec 14, 2007 (130)
44 PHARMGKB_AB_DME ss84156116 Dec 14, 2007 (130)
45 BCMHGSC_JDW ss91877550 Mar 24, 2008 (129)
46 HUMANGENOME_JCVI ss96092645 Feb 04, 2009 (130)
47 SHGC ss99307578 Feb 04, 2009 (130)
48 PHARMGKB_PPII ss105109907 Feb 04, 2009 (130)
49 1000GENOMES ss112551473 Jan 25, 2009 (130)
50 1000GENOMES ss114036054 Jan 25, 2009 (130)
51 ILLUMINA-UK ss117362075 Feb 14, 2009 (130)
52 ILLUMINA ss122352974 Dec 01, 2009 (131)
53 ENSEMBL ss138335200 Dec 01, 2009 (131)
54 ENSEMBL ss143168685 Dec 01, 2009 (131)
55 ILLUMINA ss154307142 Dec 01, 2009 (131)
56 GMI ss157034606 Dec 01, 2009 (131)
57 ILLUMINA ss159483938 Dec 01, 2009 (131)
58 SEATTLESEQ ss159743879 Dec 01, 2009 (131)
59 ILLUMINA ss160697633 Dec 01, 2009 (131)
60 COMPLETE_GENOMICS ss168891628 Jul 04, 2010 (132)
61 OMICIA ss169700809 Aug 28, 2012 (137)
62 COMPLETE_GENOMICS ss171832778 Jul 04, 2010 (132)
63 ILLUMINA ss171858824 Jul 04, 2010 (132)
64 ILLUMINA ss173777592 Jul 04, 2010 (132)
65 BUSHMAN ss204050448 Jul 04, 2010 (132)
66 BCM-HGSC-SUB ss208830194 Jul 04, 2010 (132)
67 1000GENOMES ss228618146 Jul 14, 2010 (132)
68 1000GENOMES ss238022303 Jul 15, 2010 (132)
69 1000GENOMES ss244151662 Jul 15, 2010 (132)
70 ILLUMINA ss244300758 Jul 04, 2010 (132)
71 OMIM-CURATED-RECORDS ss275514028 Nov 22, 2010 (133)
72 GMI ss283587220 May 04, 2012 (137)
73 GMI ss287550246 Apr 25, 2013 (138)
74 PJP ss292736320 May 09, 2011 (134)
75 NHLBI-ESP ss342536620 May 09, 2011 (134)
76 ILLUMINA ss410934884 Sep 17, 2011 (135)
77 ILLUMINA ss481001618 May 04, 2012 (137)
78 ILLUMINA ss481022354 May 04, 2012 (137)
79 ILLUMINA ss482004819 Sep 08, 2015 (146)
80 ILLUMINA ss485295756 May 04, 2012 (137)
81 1000GENOMES ss491188318 May 04, 2012 (137)
82 EXOME_CHIP ss491568471 May 04, 2012 (137)
83 CLINSEQ_SNP ss491819536 May 04, 2012 (137)
84 ILLUMINA ss537257559 Sep 08, 2015 (146)
85 TISHKOFF ss566560789 Apr 25, 2013 (138)
86 SSMP ss662483744 Apr 25, 2013 (138)
87 ILLUMINA ss778542157 Sep 08, 2015 (146)
88 ILLUMINA ss780760189 Sep 08, 2015 (146)
89 ILLUMINA ss783093748 Sep 08, 2015 (146)
90 ILLUMINA ss783439072 Sep 08, 2015 (146)
91 ILLUMINA ss784051102 Sep 08, 2015 (146)
92 ILLUMINA ss825519873 Apr 01, 2015 (144)
93 ILLUMINA ss832352251 Sep 08, 2015 (146)
94 ILLUMINA ss832995358 Jul 13, 2019 (153)
95 ILLUMINA ss833998797 Sep 08, 2015 (146)
96 JMKIDD_LAB ss974512061 Aug 21, 2014 (142)
97 EVA-GONL ss995222796 Aug 21, 2014 (142)
98 JMKIDD_LAB ss1067603859 Aug 21, 2014 (142)
99 JMKIDD_LAB ss1082570467 Aug 21, 2014 (142)
100 1000GENOMES ss1366683122 Aug 21, 2014 (142)
101 DDI ss1429219785 Apr 01, 2015 (144)
102 EVA_GENOME_DK ss1579704267 Apr 01, 2015 (144)
103 EVA_FINRISK ss1584126415 Apr 01, 2015 (144)
104 EVA_UK10K_ALSPAC ss1639753950 Apr 01, 2015 (144)
105 EVA_UK10K_TWINSUK ss1682747983 Apr 01, 2015 (144)
106 EVA_EXAC ss1694228953 Apr 01, 2015 (144)
107 EVA_MGP ss1711560479 Apr 01, 2015 (144)
108 EVA_SVP ss1713731247 Apr 01, 2015 (144)
109 ILLUMINA ss1752413977 Sep 08, 2015 (146)
110 ILLUMINA ss1752413978 Sep 08, 2015 (146)
111 YSAMUELS ss1849931081 Feb 12, 2016 (147)
112 ILLUMINA ss1917953438 Feb 12, 2016 (147)
113 WEILL_CORNELL_DGM ss1938784399 Feb 12, 2016 (147)
114 ILLUMINA ss1946577642 Feb 12, 2016 (147)
115 ILLUMINA ss1959965712 Feb 12, 2016 (147)
116 GENOMED ss1969246877 Jul 19, 2016 (147)
117 JJLAB ss2030165213 Sep 14, 2016 (149)
118 USC_VALOUEV ss2158775171 Dec 20, 2016 (150)
119 HUMAN_LONGEVITY ss2246457027 Dec 20, 2016 (150)
120 TOPMED ss2413283895 Dec 20, 2016 (150)
121 SYSTEMSBIOZJU ss2629580757 Nov 08, 2017 (151)
122 ILLUMINA ss2633862775 Nov 08, 2017 (151)
123 ILLUMINA ss2633862776 Nov 08, 2017 (151)
124 ILLUMINA ss2635110818 Nov 08, 2017 (151)
125 GRF ss2704518125 Nov 08, 2017 (151)
126 GNOMAD ss2744960035 Nov 08, 2017 (151)
127 GNOMAD ss2750498451 Nov 08, 2017 (151)
128 GNOMAD ss2972986300 Nov 08, 2017 (151)
129 AFFY ss2985233274 Nov 08, 2017 (151)
130 AFFY ss2985850713 Nov 08, 2017 (151)
131 SWEGEN ss3019086373 Nov 08, 2017 (151)
132 ILLUMINA ss3022171896 Nov 08, 2017 (151)
133 EVA_SAMSUNG_MC ss3023073334 Nov 08, 2017 (151)
134 BIOINF_KMB_FNS_UNIBA ss3028920322 Nov 08, 2017 (151)
135 CSHL ss3352776493 Nov 08, 2017 (151)
136 TOPMED ss3374061092 Nov 08, 2017 (151)
137 ILLUMINA ss3628506015 Oct 12, 2018 (152)
138 ILLUMINA ss3628506016 Oct 12, 2018 (152)
139 ILLUMINA ss3631815167 Oct 12, 2018 (152)
140 ILLUMINA ss3633268864 Oct 12, 2018 (152)
141 ILLUMINA ss3633984254 Oct 12, 2018 (152)
142 ILLUMINA ss3634860950 Oct 12, 2018 (152)
143 ILLUMINA ss3634860951 Oct 12, 2018 (152)
144 ILLUMINA ss3635668891 Oct 12, 2018 (152)
145 ILLUMINA ss3636556582 Oct 12, 2018 (152)
146 ILLUMINA ss3637421084 Oct 12, 2018 (152)
147 ILLUMINA ss3638374444 Oct 12, 2018 (152)
148 ILLUMINA ss3639191045 Oct 12, 2018 (152)
149 ILLUMINA ss3639611681 Oct 12, 2018 (152)
150 ILLUMINA ss3640568251 Oct 12, 2018 (152)
151 ILLUMINA ss3640568252 Oct 12, 2018 (152)
152 ILLUMINA ss3643334852 Oct 12, 2018 (152)
153 ILLUMINA ss3644796332 Oct 12, 2018 (152)
154 OMUKHERJEE_ADBS ss3646561243 Oct 12, 2018 (152)
155 URBANLAB ss3651151884 Oct 12, 2018 (152)
156 ILLUMINA ss3652633448 Oct 12, 2018 (152)
157 ILLUMINA ss3654001338 Oct 12, 2018 (152)
158 EGCUT_WGS ss3685618877 Jul 13, 2019 (153)
159 EVA_DECODE ss3707954959 Jul 13, 2019 (153)
160 ILLUMINA ss3725957492 Jul 13, 2019 (153)
161 ACPOP ss3743823282 Jul 13, 2019 (153)
162 ILLUMINA ss3744500496 Jul 13, 2019 (153)
163 ILLUMINA ss3745160781 Jul 13, 2019 (153)
164 ILLUMINA ss3745160782 Jul 13, 2019 (153)
165 EVA ss3759230925 Jul 13, 2019 (153)
166 PAGE_CC ss3772082274 Jul 13, 2019 (153)
167 ILLUMINA ss3772656764 Jul 13, 2019 (153)
168 ILLUMINA ss3772656765 Jul 13, 2019 (153)
169 PACBIO ss3788793360 Jul 13, 2019 (153)
170 PACBIO ss3793664452 Jul 13, 2019 (153)
171 PACBIO ss3798550777 Jul 13, 2019 (153)
172 KHV_HUMAN_GENOMES ss3822398809 Jul 13, 2019 (153)
173 EVA ss3825423917 Apr 27, 2020 (154)
174 EVA ss3825534088 Apr 27, 2020 (154)
175 EVA ss3825548348 Apr 27, 2020 (154)
176 EVA ss3825965512 Apr 27, 2020 (154)
177 EVA ss3835927803 Apr 27, 2020 (154)
178 EVA ss3841592403 Apr 27, 2020 (154)
179 EVA ss3847107063 Apr 27, 2020 (154)
180 HGDP ss3847684686 Apr 27, 2020 (154)
181 SGDP_PRJ ss3890256798 Apr 27, 2020 (154)
182 KRGDB ss3940640393 Apr 27, 2020 (154)
183 KOGIC ss3983389655 Apr 27, 2020 (154)
184 FSA-LAB ss3984229795 Apr 26, 2021 (155)
185 EVA ss3984450654 Apr 26, 2021 (155)
186 EVA ss3984758329 Apr 26, 2021 (155)
187 EVA ss3985910179 Apr 26, 2021 (155)
188 EVA ss3986086722 Apr 26, 2021 (155)
189 EVA ss3986853417 Apr 26, 2021 (155)
190 EVA ss4017873655 Apr 26, 2021 (155)
191 TOPMED ss5105107985 Apr 26, 2021 (155)
192 TOMMO_GENOMICS ss5232040561 Apr 26, 2021 (155)
193 EVA ss5236988677 Apr 26, 2021 (155)
194 EVA ss5237254842 Apr 26, 2021 (155)
195 EVA ss5237615144 Apr 26, 2021 (155)
196 1000Genomes NC_000022.10 - 19951271 Oct 12, 2018 (152)
197 The Avon Longitudinal Study of Parents and Children NC_000022.10 - 19951271 Oct 12, 2018 (152)
198 Genetic variation in the Estonian population NC_000022.10 - 19951271 Oct 12, 2018 (152)
199 ExAC NC_000022.10 - 19951271 Oct 12, 2018 (152)
200 FINRISK NC_000022.10 - 19951271 Apr 27, 2020 (154)
201 The Danish reference pan genome NC_000022.10 - 19951271 Apr 27, 2020 (154)
202 gnomAD - Genomes NC_000022.11 - 19963748 Apr 26, 2021 (155)
203 gnomAD - Exomes NC_000022.10 - 19951271 Jul 13, 2019 (153)
204 Genome of the Netherlands Release 5 NC_000022.10 - 19951271 Apr 27, 2020 (154)
205 HGDP-CEPH-db Supplement 1 NC_000022.9 - 18331271 Apr 27, 2020 (154)
206 HapMap NC_000022.11 - 19963748 Apr 27, 2020 (154)
207 KOREAN population from KRGDB NC_000022.10 - 19951271 Apr 27, 2020 (154)
208 Korean Genome Project NC_000022.11 - 19963748 Apr 27, 2020 (154)
209 Medical Genome Project healthy controls from Spanish population NC_000022.10 - 19951271 Apr 27, 2020 (154)
210 Northern Sweden NC_000022.10 - 19951271 Jul 13, 2019 (153)
211 The PAGE Study NC_000022.11 - 19963748 Jul 13, 2019 (153)
212 Ancient Sardinia genome-wide 1240k capture data generation and analysis NC_000022.10 - 19951271 Apr 26, 2021 (155)
213 CNV burdens in cranial meningiomas NC_000022.10 - 19951271 Apr 26, 2021 (155)
214 MxGDAR/Encodat-PGx NC_000022.10 - 19951271 Apr 26, 2021 (155)
215 PharmGKB Aggregated NC_000022.11 - 19963748 Apr 27, 2020 (154)
216 Qatari NC_000022.10 - 19951271 Apr 27, 2020 (154)
217 SGDP_PRJ NC_000022.10 - 19951271 Apr 27, 2020 (154)
218 Siberian NC_000022.10 - 19951271 Apr 27, 2020 (154)
219 8.3KJPN NC_000022.10 - 19951271 Apr 26, 2021 (155)
220 TopMed NC_000022.11 - 19963748 Apr 26, 2021 (155)
221 UK 10K study - Twins NC_000022.10 - 19951271 Oct 12, 2018 (152)
222 A Vietnamese Genetic Variation Database NC_000022.10 - 19951271 Jul 13, 2019 (153)
223 ALFA NC_000022.11 - 19963748 Apr 26, 2021 (155)
224 ClinVar RCV000019156.4 Oct 12, 2018 (152)
225 ClinVar RCV000211145.1 Oct 12, 2018 (152)
226 ClinVar RCV000244083.1 Oct 12, 2018 (152)
227 ClinVar RCV000786523.1 Jul 13, 2019 (153)
228 ClinVar RCV000786728.1 Jul 13, 2019 (153)
229 ClinVar RCV000786729.1 Jul 13, 2019 (153)
230 ClinVar RCV000786730.1 Jul 13, 2019 (153)
231 ClinVar RCV000786731.1 Jul 13, 2019 (153)
232 ClinVar RCV000786732.1 Jul 13, 2019 (153)
233 ClinVar RCV000786733.1 Jul 13, 2019 (153)
234 ClinVar RCV001028880.1 Apr 27, 2020 (154)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs165688 Nov 14, 2002 (109)
rs1131157 Jan 04, 2002 (102)
rs2070104 Jan 04, 2002 (102)
rs3177905 Jul 03, 2002 (106)
rs3190784 Oct 08, 2002 (108)
rs3747070 Oct 08, 2002 (108)
rs11544671 Mar 11, 2006 (126)
rs17295216 Mar 11, 2006 (126)
rs17349704 Mar 11, 2006 (126)
rs17818178 Oct 07, 2004 (123)
rs17849308 Mar 11, 2006 (126)
rs17850006 Mar 11, 2006 (126)
rs58002978 May 24, 2008 (130)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss3639191045, ss3639611681 NC_000022.8:18325824:G:A NC_000022.11:19963747:G:A (self)
362578, ss91877550, ss112551473, ss114036054, ss117362075, ss168891628, ss171832778, ss204050448, ss208830194, ss283587220, ss287550246, ss292736320, ss481001618, ss491819536, ss825519873, ss1713731247, ss2635110818, ss3643334852, ss3847684686 NC_000022.9:18331270:G:A NC_000022.11:19963747:G:A (self)
80217552, 44382019, 31357125, 5801172, 122876, 5869206, 14289515, 19773905, 47817787, 676239, 17108147, 1136106, 307910, 3655, 20826321, 42273778, 11291525, 90009868, 44382019, 9792535, ss228618146, ss238022303, ss244151662, ss342536620, ss481022354, ss482004819, ss485295756, ss491188318, ss491568471, ss537257559, ss566560789, ss662483744, ss778542157, ss780760189, ss783093748, ss783439072, ss784051102, ss832352251, ss832995358, ss833998797, ss974512061, ss995222796, ss1067603859, ss1082570467, ss1366683122, ss1429219785, ss1579704267, ss1584126415, ss1639753950, ss1682747983, ss1694228953, ss1711560479, ss1752413977, ss1752413978, ss1849931081, ss1917953438, ss1938784399, ss1946577642, ss1959965712, ss1969246877, ss2030165213, ss2158775171, ss2413283895, ss2629580757, ss2633862775, ss2633862776, ss2704518125, ss2744960035, ss2750498451, ss2972986300, ss2985233274, ss2985850713, ss3019086373, ss3022171896, ss3023073334, ss3352776493, ss3628506015, ss3628506016, ss3631815167, ss3633268864, ss3633984254, ss3634860950, ss3634860951, ss3635668891, ss3636556582, ss3637421084, ss3638374444, ss3640568251, ss3640568252, ss3644796332, ss3646561243, ss3652633448, ss3654001338, ss3685618877, ss3743823282, ss3744500496, ss3745160781, ss3745160782, ss3759230925, ss3772656764, ss3772656765, ss3788793360, ss3793664452, ss3798550777, ss3825423917, ss3825534088, ss3825548348, ss3825965512, ss3835927803, ss3841592403, ss3890256798, ss3940640393, ss3984229795, ss3984450654, ss3984758329, ss3985910179, ss3986086722, ss3986853417, ss4017873655, ss5232040561, ss5237615144 NC_000022.10:19951270:G:A NC_000022.11:19963747:G:A (self)
RCV000019156.4, RCV000211145.1, RCV000244083.1, RCV000786523.1, RCV000786728.1, RCV000786729.1, RCV000786730.1, RCV000786731.1, RCV000786732.1, RCV000786733.1, RCV001028880.1, 566543865, 2227945, 39767656, 1303743, 7572, 237443423, 380216932, 5950756585, ss169700809, ss275514028, ss2246457027, ss3028920322, ss3374061092, ss3651151884, ss3707954959, ss3725957492, ss3772082274, ss3822398809, ss3847107063, ss3983389655, ss5105107985, ss5236988677, ss5237254842 NC_000022.11:19963747:G:A NC_000022.11:19963747:G:A (self)
ss5363, ss10902, ss232568, ss458935, ss593353, ss869771, ss1058120, ss1525135, ss1750406, ss2419858, ss2982266, ss4394550, ss4415842, ss4933092, ss5586357, ss6311517, ss6312623, ss12586777, ss12673767, ss16240705, ss21854500, ss22886949, ss24702135, ss28503610, ss28504308, ss35031502, ss41527572, ss48429990, ss65728351, ss65824277, ss66561034, ss66862091, ss67358029, ss67746210, ss69277073, ss69367705, ss70815561, ss71396394, ss75741500, ss76724792, ss76883807, ss79189355, ss83346610, ss84156116, ss96092645, ss99307578, ss105109907, ss122352974, ss138335200, ss143168685, ss154307142, ss157034606, ss159483938, ss159743879, ss160697633, ss171858824, ss173777592, ss244300758, ss410934884 NT_011519.10:3103420:G:A NC_000022.11:19963747:G:A (self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

791 citations for rs4680
PMID Title Author Year Journal
848488 Inheritance of low erythrocyte catechol-o-methyltransferase activity in man. Weinshilboum RM et al. 1977 American journal of human genetics
7304673 Genetics of red cell COMT activity: analysis of thermal stability and family data. Spielman RS et al. 1981 American journal of medical genetics
7585135 The psychobiological regulation of social cooperation. Cloninger CR et al. 1995 Nature medicine
8807664 Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Lachman HM et al. 1996 Pharmacogenetics
8886163 Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome. Lachman HM et al. 1996 American journal of medical genetics
8941353 No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferase. Hoda F et al. 1996 Biochemical and biophysical research communications
9110364 Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland. Syvänen AC et al. 1997 Pharmacogenetics
10395222 Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. Tiihonen J et al. 1999 Molecular psychiatry
10459407 Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Palmatier MA et al. 1999 Biological psychiatry
11171904 The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese. Wu RM et al. 2001 Neurology
11381111 Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Egan MF et al. 2001 Proceedings of the National Academy of Sciences of the United States of America
11502905 Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism. Graf WD et al. 2001 Neurology
11772685 Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. Rotondo A et al. 2002 The American journal of psychiatry
11925305 A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Malhotra AK et al. 2002 The American journal of psychiatry
12192614 Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Avramopoulos D et al. 2002 Molecular psychiatry
12359690 Catechol O-methyltransferase genetic polymorphism in panic disorder. Woo JM et al. 2002 The American journal of psychiatry
12402217 A highly significant association between a COMT haplotype and schizophrenia. Shifman S et al. 2002 American journal of human genetics
12436243 Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation. DeMille MM et al. 2002 Human genetics
12595695 COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Zubieta JK et al. 2003 Science (New York, N.Y.)
12611827 Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies. Glatt SJ et al. 2003 The American journal of psychiatry
12716966 Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Mattay VS et al. 2003 Proceedings of the National Academy of Sciences of the United States of America
12802784 A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Bray NJ et al. 2003 American journal of human genetics
12842306 A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Rujescu D et al. 2003 Biological psychiatry
14966473 Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes. Shield AJ et al. 2004 Molecular psychiatry
15098000 COMT haplotypes suggest P2 promoter region relevance for schizophrenia. Palmatier MA et al. 2004 Molecular psychiatry
15124004 Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families. Chen X et al. 2004 Molecular psychiatry
15169701 New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis. Rosa A et al. 2004 The American journal of psychiatry
15290009 Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay. Zhu G et al. 2004 Psychopharmacology
15457404 Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Chen J et al. 2004 American journal of human genetics
15457497 Relationship of MAO-A promoter (u-VNTR) and COMT (V158M) gene polymorphisms to CSF monoamine metabolites levels in a psychiatric sample of caucasians: A preliminary report. Zalsman G et al. 2005 American journal of medical genetics. Part B, Neuropsychiatric genetics
15505638 Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia. Handoko HY et al. 2005 Molecular psychiatry
15645182 Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Lee SG et al. 2005 Human genetics
15652872 Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis. Fan JB et al. 2005 Biological psychiatry
15821730 Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Meyer-Lindenberg A et al. 2005 Nature neuroscience
15824744 Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies. Munafò MR et al. 2005 Molecular psychiatry
15931594 An entropy-based statistic for genomewide association studies. Zhao J et al. 2005 American journal of human genetics
15935994 COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome. Baker K et al. 2005 Biological psychiatry
15956988 COMT polymorphisms and anxiety-related personality traits. Stein MB et al. 2005 Neuropsychopharmacology
16027741 Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease. Sweet RA et al. 2005 Molecular psychiatry
16043133 Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Bruder GE et al. 2005 Biological psychiatry
16130008 Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: a family-based association study in a Chinese population. Tsai SJ et al. 2006 Molecular psychiatry
16135635 No association between schizophrenia and polymorphisms in COMT in two large samples. Williams HJ et al. 2005 The American journal of psychiatry
16232322 COMT genetic variation confers risk for psychotic and affective disorders: a case control study. Funke B et al. 2005 Behavioral and brain functions
16275815 Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Thapar A et al. 2005 Archives of general psychiatry
16380905 Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Fallin MD et al. 2005 American journal of human genetics
16380908 Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. Hawi Z et al. 2005 American journal of human genetics
16395295 Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. Beuten J et al. 2006 Neuropsychopharmacology
16412218 Multilocus analysis of SNP and metabolic data within a given pathway. Kristensen VN et al. 2006 BMC genomics
16453988 Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease. Rissling I et al. 2006 Sleep
16483362 The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. Dempster EL et al. 2006 BMC medical genetics
16513880 No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome. Glaser B et al. 2006 The American journal of psychiatry
16542388 Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome. Shashi V et al. 2006 Clinical genetics
16574089 PCR screening for 22q11.2 microdeletion: development of a new cost-effective diagnostic tool. Gioli-Pereira L et al. 2006 Clinica chimica acta; international journal of clinical chemistry
16786032 Impact of complex genetic variation in COMT on human brain function. Meyer-Lindenberg A et al. 2006 Molecular psychiatry
16816420 Nonlinear tests for genomewide association studies. Zhao J et al. 2006 Genetics
16816940 Direct molecular haplotyping of multiple polymorphisms within exon 4 of the human catechol-O-methyltransferase gene by liquid chromatography-electrospray ionization time-of-flight mass spectrometry. Oberacher H et al. 2006 Analytical and bioanalytical chemistry
16837108 Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease. Borroni B et al. 2007 Neurobiology of aging
16848906 Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans. Kim H et al. 2006 Molecular pain
16882734 Genetic predictors for acute experimental cold and heat pain sensitivity in humans. Kim H et al. 2006 Journal of medical genetics
17006672 Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. Nicodemus KK et al. 2007 Human genetics
17116718 Dietary phytoestrogen intake is associated with reduced colorectal cancer risk. Cotterchio M et al. 2006 The Journal of nutrition
17299513 Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait. Lang UE et al. 2007 Neuropsychopharmacology
17363961 Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment. Molero P et al. 2007 The pharmacogenomics journal
17427186 Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study. Yu R et al. 2007 American journal of medical genetics. Part B, Neuropsychiatric genetics
17429315 Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. Long JR et al. 2007 Pharmacogenetics and genomics
17442488 An association study between cathechol-O-methyltransferase gene and mental retardation in the Chinese Han population. Zhang K et al. 2007 Neuroscience letters
17466074 Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. Ton TG et al. 2007 Behavioral and brain functions
17482701 No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population. Nunokawa A et al. 2007 Neuroscience research
17483451 Gene-gene interaction associated with neural reward sensitivity. Yacubian J et al. 2007 Proceedings of the National Academy of Sciences of the United States of America
17504246 Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia. Zinkstok J et al. 2008 Genes, brain, and behavior
17504906 The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men. Stolk L et al. 2007 The Journal of clinical endocrinology and metabolism
17548664 Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial. Johnstone EC et al. 2007 Cancer epidemiology, biomarkers & prevention
17604122 A quantitative association study between schizotypal traits and COMT, PRODH and BDNF genes in a healthy Chinese population. Ma X et al. 2007 Psychiatry research
17630406 Dopamine genes and schizophrenia: case closed or evidence pending? Talkowski ME et al. 2007 Schizophrenia bulletin
17636223 Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata. Gooden KM et al. 2007 Reproductive sciences (Thousand Oaks, Calif.)
17707347 Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls. Diaz-Asper CM et al. 2008 Biological psychiatry
17949513 Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS. Michaelovsky E et al. 2008 The international journal of neuropsychopharmacology
17961261 Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. Vargas-Alarcón G et al. 2007 Arthritis research & therapy
17994190 Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults. Retz W et al. 2008 Journal of neural transmission (Vienna, Austria
18064318 Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk. Gellekink H et al. 2007 Thrombosis and haemostasis
18081002 Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials. Juckel G et al. 2008 Human psychopharmacology
18180394 Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. Fung MM et al. 2008 Circulation
18192898 Association of COMT Val108/158Met genotype with smoking cessation. Munafò MR et al. 2008 Pharmacogenetics and genomics
18196244 Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Tander B et al. 2008 Rheumatology international
18213617 Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population. Aguilera M et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
18235427 Catechol-O-methyltransferase (COMT) val158met genotype is associated with BOLD response as a function of task characteristic. Ettinger U et al. 2008 Neuropsychopharmacology
18324659 COMT polymorphisms affecting protein expression are risk factors for endometrial cancer. Hirata H et al. 2008 Molecular carcinogenesis
18340529 A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk. He C et al. 2009 Breast cancer research and treatment
18351593 DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents. Bombin I et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
18384078 Association study of candidate variants of COMT with neuroticism, anxiety and depression. Wray NR et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
18389087 Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing. Kan T et al. 2007 Bioinformatics and biology insights
18408230 Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"? Prasad KM et al. 2008 Schizophrenia bulletin
18436194 Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Hettema JM et al. 2008 Biological psychiatry
18444252 Neurotransmission and bipolar disorder: a systematic family-based association study. Shi J et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
18466599 Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels. Xing C et al. 2007 BMC proceedings
18466879 Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample. Soronen P et al. 2008 Biological psychiatry
18486967 A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A). Shiels MS et al. 2008 Preventive medicine
18562342 Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia. Haraldsson HM et al. 2010 Schizophrenia bulletin
18574484 The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase. Mukherjee N et al. 2010 Molecular psychiatry
18592033 Sex steroid-related candidate genes in psychiatric disorders. Westberg L et al. 2008 Journal of psychiatry & neuroscience
18593984 Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. Bell DW et al. 2008 Clinical cancer research
18628428 Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer. Diergaarde B et al. 2008 Cancer epidemiology, biomarkers & prevention
18663369 Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Strug LJ et al. 2010 Molecular psychiatry
18698234 The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications. Bialecka M et al. 2008 Pharmacogenetics and genomics
18704099 Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. Lohoff FW et al. 2008 Neuropsychopharmacology
18715757 Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Shi J et al. 2008 Schizophrenia research
18755576 Effect of COMT val158met genotype on cognition and personality. Sheldrick AJ et al. 2008 European psychiatry
18787887 Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures. Tranah GJ et al. 2008 Calcified tissue international
18802928 Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults. Halleland H et al. 2009 American journal of medical genetics. Part B, Neuropsychiatric genetics
18805939 Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis. Tempfer CB et al. 2009 Human reproduction update
18820009 Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers. Hamaguchi M et al. 2008 Japanese journal of clinical oncology
18929622 Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy. Huuhka K et al. 2008 Neuroscience letters
18937309 Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study. Biederman J et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
18988738 MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met. Roffman JL et al. 2008 Proceedings of the National Academy of Sciences of the United States of America
18989660 The catechol-O-methyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting. Benedetti F et al. 2009 Psychopharmacology
19071221 Impact of interacting functional variants in COMT on regional gray matter volume in human brain. Honea R et al. 2009 NeuroImage
19074205 Drinking green tea modestly reduces breast cancer risk. Shrubsole MJ et al. 2009 The Journal of nutrition
19077118 Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia. Liao SY et al. 2009 Genes, brain, and behavior
19094200 Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. Rakvåg TT et al. 2008 Molecular pain
19094875 [Effect of polymorphisms of the cathecol-O-methyltransferase on schizophrenia risk in a Spanish population]. Mas S et al. 2008 Medicina clinica
19127255 Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. Pearce CL et al. 2009 British journal of cancer
19156168 Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Need AC et al. 2009 European journal of human genetics
19174490 Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Cote ML et al. 2009 Carcinogenesis
19197363 A genome-wide investigation of SNPs and CNVs in schizophrenia. Need AC et al. 2009 PLoS genetics
19207030 Genetic susceptibility to schizophrenia: role of dopaminergic pathway gene polymorphisms. Gupta M et al. 2009 Pharmacogenomics
19214745 Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists. Sigurdson AJ et al. 2009 Breast cancer research and treatment
19258022 Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Boettiger CA et al. 2009 Pharmacology, biochemistry, and behavior
19287484 Clique-finding for heterogeneity and multidimensionality in biomarker epidemiology research: the CHAMBER algorithm. Mushlin RA et al. 2009 PloS one
19290789 Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment. Gupta M et al. 2009 Pharmacogenomics
19329282 Meta-analysis of association between genetic variants in COMT and schizophrenia: an update. Okochi T et al. 2009 Schizophrenia research
19359258 Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project. Goodyer IM et al. 2010 International journal of epidemiology
19365560 Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs. Nackley AG et al. 2009 PloS one
19367610 Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients. Hoenicka J et al. 2010 American journal of medical genetics. Part B, Neuropsychiatric genetics
19369177 Association of the 3' region of COMT with schizophrenia in Taiwan. Chien YL et al. 2009 Journal of the Formosan Medical Association = Taiwan yi zhi
19379518 Development of a fingerprinting panel using medically relevant polymorphisms. Cross DS et al. 2009 BMC medical genomics
19417742 Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. Mier D et al. 2010 Molecular psychiatry
19474754 Antidepressive-drug-induced bodyweight gain is associated with polymorphisms in genes coding for COMT and TPH1. Secher A et al. 2009 International clinical psychopharmacology
19520435 Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism. Benedetti F et al. 2010 Journal of affective disorders
19545856 Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study. Quednow BB et al. 2009 Biological psychiatry
19578924 The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis. Zhang Z et al. 2009 Journal of neural transmission (Vienna, Austria
19582565 Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. Gadow KD et al. 2009 Journal of autism and developmental disorders
19584770 Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events. Breitling LP et al. 2009 Pharmacogenetics and genomics
19621370 Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. Dillon DG et al. 2010 Human brain mapping
19647329 COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia. Haraldsson HM et al. 2009 Psychiatry research
19664744 A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease. Ko DC et al. 2009 American journal of human genetics
19690620 Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes. Kring SI et al. 2009 PloS one
19693005 Executive function, neural circuitry, and genetic mechanisms in schizophrenia. Eisenberg DP et al. 2010 Neuropsychopharmacology
19693267 Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. Roe BE et al. 2009 PloS one
19721400 Association between COMT gene and Chinese male schizophrenic patients with violent behavior. Gu Y et al. 2009 Medical science monitor
19734545 A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC et al. 2009 Human molecular genetics
19736300 Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases. Mori M et al. 2009 The Journal of physiology
19852950 The association of catechol-O-methyltransferase genotype with the phenotype of women with eating disorders. Mikołajczyk E et al. 2010 Brain research
19911060 Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint. Doi N et al. 2009 PloS one
19915868 Monoamine oxidase A gene polymorphisms and enzyme activity associated with risk of gout in Taiwan aborigines. Tu HP et al. 2010 Human genetics
19940176 Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans. Blasi G et al. 2009 The Journal of neuroscience
19944766 A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. Meda SA et al. 2010 NeuroImage
19946713 Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant. Pálmason H et al. 2010 Journal of neural transmission (Vienna, Austria
19997043 Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents. DeYoung CG et al. 2010 Psychiatric genetics
20070134 Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample. Amstadter AB et al. 2009 Psychiatry
20071037 Catechol-O-methyltransferase val108/158met genotype, major depressive disorder and response to selective serotonin reuptake inhibitors in major depressive disorder. Illi A et al. 2010 Psychiatry research
20083391 A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry. Strohmaier J et al. 2010 Schizophrenia research
20122740 Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. Benedetti F et al. 2010 Journal of affective disorders
20125193 Common genetic variation and performance on standardized cognitive tests. Cirulli ET et al. 2010 European journal of human genetics
20148275 Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. Rommelse NN et al. 2010 European child & adolescent psychiatry
20150638 Association of COMT haplotypes and breast cancer risk in caucasian women. Peterson NB et al. 2010 Anticancer research
20157235 Genetics of psychosis in Alzheimer's disease: a review. DeMichele-Sweet MA et al. 2010 Journal of Alzheimer's disease
20179754 Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance. Bertolino A et al. 2010 PloS one
20191112 The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives. Pinheiro AP et al. 2009 International journal of child and adolescent health
20205808 Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. Nemoda Z et al. 2010 Behavioral and brain functions
20333729 A functional variant provided further evidence for the association of ARVCF with schizophrenia. Mas S et al. 2010 American journal of medical genetics. Part B, Neuropsychiatric genetics
20357209 Molecular genetic studies of gene identification for osteoporosis: the 2009 update. Xu XH et al. 2010 Endocrine reviews
20357758 Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT. Marenco S et al. 2010 Neuropsychopharmacology
20431430 The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness. Salo J et al. 2010 Psychiatric genetics
20483479 Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia. Wang Y et al. 2010 Psychiatry research
20488458 Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analysis. Costas J et al. 2011 Journal of psychiatric research
20505544 Effect of hormone metabolism genotypes on steroid hormone levels and menopausal symptoms in a prospective population-based cohort of women experiencing the menopausal transition. Rebbeck TR et al. 2010 Menopause (New York, N.Y.)
20509070 Association between hypnotizability and the catechol-O-methyltransferase (COMT) polymorphism. Szekely A et al. 2010 The International journal of clinical and experimental hypnosis
20531207 The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study. Kocabas NA et al. 2010 International clinical psychopharmacology
20532872 Genetics of caffeine consumption and responses to caffeine. Yang A et al. 2010 Psychopharmacology
20549395 Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies. Cornelis MC et al. 2010 Current psychiatry reports
20565774 Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project. Cross DS et al. 2010 BMC genetics
20570835 No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain. Nicholl BI et al. 2010 Annals of the rheumatic diseases
20627703 The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder. Fijal B et al. 2010 The journal of pain
20631687 Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility. Zhang H et al. 2010 Neuropsychopharmacology
20633049 Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes? Middeldorp CM et al. 2010 Genes, brain, and behavior
20667552 Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study. Calati R et al. 2011 Journal of psychiatric research
20691427 Genetic associations of brain structural networks in schizophrenia: a preliminary study. Jagannathan K et al. 2010 Biological psychiatry
20728009 Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism. Demetrovics Z et al. 2010 Comprehensive psychiatry
20729390 Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women. Olivo-Marston SE et al. 2010 Carcinogenesis
20732903 Predicting sensation seeking from dopamine genes. A candidate-system approach. Derringer J et al. 2010 Psychological science
20863768 Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease. Dai F et al. 2010 The spine journal
20877297 Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response. Ji Y et al. 2012 The pharmacogenomics journal
20878621 Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study. Moreno-Galván M et al. 2010 The International journal of biological markers
20934307 The 2nd Schizophrenia International Research Society Conference, 10-14 April 2010, Florence, Italy: summaries of oral sessions. Baharnoori M et al. 2010 Schizophrenia research
20934310 HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association. Voisey J et al. 2012 European psychiatry
20979431 Polymorphisms of COMT and XPD and risk of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China. Huang CG et al. 2011 Biomarkers
21049304 Influence of candidate genes on attention problems in children: a longitudinal study. van Beijsterveldt CE et al. 2011 Behavior genetics
21059181 Polymorphisms of adrenergic cardiovascular control genes are associated with adolescent chronic fatigue syndrome. Sommerfeldt L et al. 2011 Acta paediatrica (Oslo, Norway
21083670 Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). Hack LM et al. 2011 Alcoholism, clinical and experimental research
21085187 Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. Birlea SA et al. 2011 The Journal of investigative dermatology
21092186 Polymorphisms in genes involved in the estrogen pathway and mammographic density. Dumas I et al. 2010 BMC cancer
21106664 Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women. Munafò MR et al. 2011 Nicotine & tobacco research
21120493 Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients. Barbosa FR et al. 2012 Rheumatology international
21130573 COMT moderates the relation of daily maladaptive coping and pain in fibromyalgia. Finan PH et al. 2011 Pain
21144097 The impact of the catechol-O-methyltransferase genotype on the acute responsiveness of vascular reactivity to a green tea extract. Miller RJ et al. 2011 The British journal of nutrition
21162693 Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction. Zhang JP et al. 2011 Expert opinion on drug metabolism & toxicology
21172166 Pharmacogenetics of antidepressant response. Porcelli S et al. 2011 Journal of psychiatry & neuroscience
21197301 Recent advances in the use of opioids for cancer pain. Droney J et al. 2009 Journal of pain research
21204206 Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population. Carter TC et al. 2011 American journal of medical genetics. Part A
21215384 Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex. Nixon DC et al. 2011 Biological psychiatry
21216270 Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands. Das M et al. 2011 Progress in neuro-psychopharmacology & biological psychiatry
21217836 No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population. Kang HJ et al. 2010 Epidemiology and health
21225419 Gene-environment interactions: early life stress and risk for depressive and anxiety disorders. Nugent NR et al. 2011 Psychopharmacology
21280081 The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial. Corvol JC et al. 2011 Annals of neurology
21289622 Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy. Sadee W et al. 2011 Clinical pharmacology and therapeutics
21300128 COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa. Yilmaz Z et al. 2011 Progress in neuro-psychopharmacology & biological psychiatry
21300759 EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients. Yang SY et al. 2011 Clinical cancer research
21302343 The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. Rizzi TS et al. 2011 American journal of medical genetics. Part B, Neuropsychiatric genetics
21304959 Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia. Hill LD et al. 2011 PloS one
21310591 Interaction between COMT haplotypes and cannabis in schizophrenia: a case-only study in two samples from Spain. Costas J et al. 2011 Schizophrenia research
21319490 Imaging genetics of schizophrenia. Meyer-Lindenberg A et al. 2010 Dialogues in clinical neuroscience
21330274 Pharmacogenetics of smoking cessation in general practice: results from the patch II and patch in practice trials. David SP et al. 2011 Nicotine & tobacco research
21333900 The role of genetics in IBS. Saito YA et al. 2011 Gastroenterology clinics of North America
21355050 A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2). Roten LT et al. 2011 Molecular human reproduction
21356266 Interactions between the COMT Val108/158Met polymorphism and maternal prenatal smoking predict aggressive behavior outcomes. Brennan PA et al. 2011 Biological psychology
21368917 Epistasis between neurochemical gene polymorphisms and risk for ADHD. Segurado R et al. 2011 European journal of human genetics
21423693 Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures. Doehring A et al. 2011 PloS one
21440309 Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD. Boscarino JA et al. 2011 Psychiatry research
21445667 Variation in genes involved in dopamine clearance influence the startle response in older adults. Armbruster D et al. 2011 Journal of neural transmission (Vienna, Austria
21449006 Role of COMT, 5-HT(1A) , and SERT genetic polymorphisms on antidepressant response to Transcranial Magnetic Stimulation. Malaguti A et al. 2011 Depression and anxiety
21462137 [An association study of COMT gene polymorphisms with schizophrenia]. KONG FZ et al. 2011 Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
21467728 Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Wakai K et al. 2011 Journal of epidemiology
21486391 The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide. Pivac N et al. 2011 Genes, brain, and behavior
21495799 COMT polymorphism and the risk of endometriosis-related infertility. Christofolini DM et al. 2011 Gynecological endocrinology
21504842 Dietary, lifestyle and pharmacogenetic factors associated with arteriole endothelial-dependent vasodilatation in schizophrenia patients treated with atypical antipsychotics (AAPs). Ellingrod VL et al. 2011 Schizophrenia research
21508242 Dopaminergic genes predict individual differences in susceptibility to confirmation bias. Doll BB et al. 2011 The Journal of neuroscience
21514219 Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Zhang B et al. 2011 The Lancet. Oncology
21527290 Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. Nemoda Z et al. 2011 Neuroscience and biobehavioral reviews
21567099 Estrogen metabolism genotypes, use of long-term hormone replacement therapy and risk of postmenopausal breast cancer. Cerne JZ et al. 2011 Oncology reports
21570824 Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids. Laugsand EA et al. 2011 European journal of cancer (Oxford, England
21593733 Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Nikolova YS et al. 2011 Neuropsychopharmacology
21595525 Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder. Ancín I et al. 2011 The world journal of biological psychiatry
21600957 COMT and age at onset in mood disorders: a replication and extension study. Massat I et al. 2011 Neuroscience letters
21609749 Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability. Bhowmik AD et al. 2011 Progress in neuro-psychopharmacology & biological psychiatry
21610500 Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Schmidt RJ et al. 2011 Epidemiology (Cambridge, Mass.)
21655053 The genetic basis of panic disorder. Na HR et al. 2011 Journal of Korean medical science
21656904 Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. Ittiwut R et al. 2011 American journal of medical genetics. Part B, Neuropsychiatric genetics
21687501 Pharmacogenetics of antidepressants. Crisafulli C et al. 2011 Frontiers in pharmacology
21711518 Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B &NTRK2 polymorphisms. Murphy TM et al. 2011 Behavioral and brain functions
21749372 Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects. Luijk MP et al. 2011 Journal of child psychology and psychiatry, and allied disciplines
21765900 Contributions of dopamine-related genes and environmental factors to highly sensitive personality: a multi-step neuronal system-level approach. Chen C et al. 2011 PloS one
21776034 Association of the catechol-O-methyl transferase gene Val158Met polymorphism with blood pressure and prevalence of hypertension: interaction with dietary energy intake. Htun NC et al. 2011 American journal of hypertension
21781348 Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population. Kiyohara C et al. 2011 BMC neurology
21808609 Components of cross-frequency modulation in health and disease. Allen EA et al. 2011 Frontiers in systems neuroscience
21836667 Molecular biology research in neuropsychiatry: India's contribution. Sathyanarayana Rao TS et al. 2010 Indian journal of psychiatry
21857968 Role of novelty seeking personality traits as mediator of the association between COMT and onset age of drug use in Chinese heroin dependent patients. Li T et al. 2011 PloS one
21895373 Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism. Desmeules J et al. 2012 Health psychology
21905019 Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia. Smith SB et al. 2012 Arthritis and rheumatism
21934638 A COMT gene haplotype associated with methamphetamine abuse. Jugurnauth SK et al. 2011 Pharmacogenetics and genomics
21934689 Is there a genetic cause for cancer cachexia? - a clinical validation study in 1797 patients. Solheim TS et al. 2011 British journal of cancer
21935354 Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. Dewey FE et al. 2011 PLoS genetics
21940152 The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder--a European multicenter study. Schosser A et al. 2012 European neuropsychopharmacology
21947654 Cannabis, COMT and psychotic experiences. Zammit S et al. 2011 The British journal of psychiatry
21958689 Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes. Trabert B et al. 2011 Fertility and sterility
21999147 Diverse facets of COMT: from a plausible predictive marker to a potential drug target for schizophrenia. Gupta M et al. 2011 Current molecular medicine
22021659 Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia. Roffman JL et al. 2013 Schizophrenia bulletin
22021758 Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort. Nyman ES et al. 2011 BMJ open
22024213 A novel gene-environment interaction involved in endometriosis. McCarty CA et al. 2012 International journal of gynaecology and obstetrics
22024485 Genetic associations with performance on a behavioral measure of distress intolerance. Amstadter AB et al. 2012 Journal of psychiatric research
22067551 When control fails: influence of the prefrontal but not striatal dopaminergic system on behavioural flexibility in a change detection task. Schulz S et al. 2012 Neuropharmacology
22087305 BDNF polymorphism predicts general intelligence after penetrating traumatic brain injury. Rostami E et al. 2011 PloS one
22103610 Biomarkers to optimize the treatment of nicotine dependence. Schnoll RA et al. 2011 Biomarkers in medicine
22105624 The genetics of attention deficit/hyperactivity disorder in adults, a review. Franke B et al. 2012 Molecular psychiatry
22170288 Translational genetic approaches to substance use disorders: bridging the gap between mice and humans. Palmer AA et al. 2012 Human genetics
22178088 Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome. Hill LD et al. 2012 Molecular and cellular endocrinology
22224195 Epigenetics in Developmental Disorder: ADHD and Endophenotypes. Archer T et al. 2011 Journal of genetic syndromes & gene therapy
22259185 Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity. Varga G et al. 2012 American journal of medical genetics. Part B, Neuropsychiatric genetics
22293393 Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity. Hiyoshi M et al. 2012 Gene
22301281 Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk. Jang JH et al. 2012 Carcinogenesis
22337560 The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation. Jacobsen LM et al. 2012 European journal of pain (London, England)
22348020 Exogenous visual orienting is associated with specific neurotransmitter genetic markers: a population-based genetic association study. Lundwall RA et al. 2012 PloS one
22349272 Age modulates the effect of COMT genotype on delay discounting behavior. Smith CT et al. 2012 Psychopharmacology
22366815 Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data. Brandys MK et al. 2012 Psychiatric genetics
22367361 Replication study for reported SNP associations with breast cancer survival. Beeghly-Fadiel A et al. 2012 Journal of cancer research and clinical oncology
22418777 Estrogen-related genes and their contribution to racial differences in breast cancer risk. Reding KW et al. 2012 Cancer causes & control
22438994 Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test. Lim J et al. 2012 PloS one
22451510 Catechol-o-methyltransferase gene and executive function in children with ADHD. Choudhry Z et al. 2014 Journal of attention disorders
22466345 Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women. Butts SF et al. 2012 The Journal of clinical endocrinology and metabolism
22487365 C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate. Huertas E et al. 2012 Genes, brain, and behavior
22528689 Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene. Martínez-Jauand M et al. 2013 European journal of pain (London, England)
22530780 Impact of five SNPs in dopamine-related genes on executive function. Mitaki S et al. 2013 Acta neurologica Scandinavica
22535570 Is there a genetic cause of appetite loss?-an explorative study in 1,853 cancer patients. Solheim TS et al. 2012 Journal of cachexia, sarcopenia and muscle
22536069 Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment. Boscarino JA et al. 2012 Neuropsychiatric disease and treatment
22552919 Bioinformatics and variability in drug response: a protein structural perspective. Lahti JL et al. 2012 Journal of the Royal Society, Interface
22615781 Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study. Bakker PR et al. 2012 PloS one
22623973 An improved PSO algorithm for generating protective SNP barcodes in breast cancer. Chuang LY et al. 2012 PloS one
22640745 The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD. Matthews N et al. 2012 Behavioral and brain functions
22645715 Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study. Heck JE et al. 2012 Frontiers in oncology
22655260 Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations. Kalari KR et al. 2012 Frontiers in oncology
22658813 Association between polymorphisms in COMT, PLCH1, and CYP17A1, and non-small-cell lung cancer risk in Chinese nonsmokers. Zhang Y et al. 2013 Clinical lung cancer
22683321 Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology. Thaler L et al. 2012 Progress in neuro-psychopharmacology & biological psychiatry
22695756 Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy. Sun H et al. 2012 Journal of neural transmission (Vienna, Austria
22701660 Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guérin. Wei H et al. 2012 PloS one
22713126 COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder. Soeiro-de-Souza MG et al. 2012 Bipolar disorders
22718527 The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation. Henker RA et al. 2013 Biological research for nursing
22719919 Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study. dos Santos VA et al. 2012 PloS one
22722321 Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis. Tammimäki A et al. 2012 Pharmacogenetics and genomics
22763378 Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms. Shashi V et al. 2012 European journal of human genetics
22784685 The COMT Met158 allele and violence in schizophrenia: a meta-analysis. Bhakta SG et al. 2012 Schizophrenia research
22832657 A review on experimental and clinical genetic associations studies on fear conditioning, extinction and cognitive-behavioral treatment. Lonsdorf TB et al. 2011 Translational psychiatry
22832821 Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development. Ziermans T et al. 2012 Translational psychiatry
22841130 Shared and unique genetic contributions to attention deficit/hyperactivity disorder and substance use disorders: a pilot study of six candidate genes. Carpentier PJ et al. 2013 European neuropsychopharmacology
22890010 Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease. Białecka M et al. 2012 Pharmacogenetics and genomics
22890094 Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients. Lanni C et al. 2012 Journal of Alzheimer's disease
22900954 COMT val158met predicts reward responsiveness in humans. Lancaster TM et al. 2012 Genes, brain, and behavior
22901597 Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia. Poletti S et al. 2013 Comprehensive psychiatry
22956598 Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. Peters MJ et al. 2013 Annals of the rheumatic diseases
22963930 Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent. Al-Eitan LN et al. 2012 BMC research notes
22978509 Convergence of genome-wide association and candidate gene studies for alcoholism. Olfson E et al. 2012 Alcoholism, clinical and experimental research
22992668 Pharmacogenomics knowledge for personalized medicine. Whirl-Carrillo M et al. 2012 Clinical pharmacology and therapeutics
23000097 Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women. Martínez-Ramírez OC et al. 2013 Breast (Edinburgh, Scotland)
23008195 Genetic variants in the catechol-o-methyltransferase gene are associated with impulsivity and executive function: relevance for major depression. Pap D et al. 2012 American journal of medical genetics. Part B, Neuropsychiatric genetics
23069674 No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. Creese B et al. 2012 Neuroscience letters
23112845 Epistasis analysis for estrogen metabolic and signaling pathway genes on young ischemic stroke patients. Hsieh YC et al. 2012 PloS one
23133420 Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin. Suarez-Kurtz G et al. 2012 Frontiers in pharmacology
23139742 Functional analyses of endometriosis-related polymorphisms in the estrogen synthesis and metabolism-related genes. Wang HS et al. 2012 PloS one
23141115 The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity in patients with panic disorder. Kim B et al. 2013 Journal of affective disorders
23178897 The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence. Gaysina D et al. 2013 Biological psychology
23209597 Investigating the genetic basis of theory of mind (ToM): the role of catechol-O-methyltransferase (COMT) gene polymorphisms. Xia H et al. 2012 PloS one
23219927 Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism. Zhang X et al. 2013 NeuroImage
23226061 The role of genetics in pre-eclampsia and potential pharmacogenomic interventions. Williams PJ et al. 2012 Pharmacogenomics and personalized medicine
23248619 Chemotherapy refractory testicular germ cell tumor is associated with a variant in Armadillo Repeat gene deleted in Velco-Cardio-Facial syndrome (ARVCF). Fung C et al. 2012 Frontiers in endocrinology
23261162 DBH -1021C>T and COMT Val108/158Met genotype are not associated with the P300 ERP in an auditory oddball task. Spronk DB et al. 2013 Clinical neurophysiology
23278923 The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation. Landi N et al. 2013 Developmental science
23283688 Common variants in psychiatric risk genes predict brain structure at birth. Knickmeyer RC et al. 2014 Cerebral cortex (New York, N.Y.
23288874 Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study. Mutschler J et al. 2013 Nicotine & tobacco research
23302985 The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia. Landau R et al. 2013 Anesthesia and analgesia
23351565 Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability. Hatzimanolis A et al. 2013 Journal of affective disorders
23353103 COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study. Kontis D et al. 2013 Neuroscience letters
23358850 Genetic variants in sex hormone metabolic pathway genes and risk of esophageal squamous cell carcinoma. Hyland PL et al. 2013 Carcinogenesis
23370603 Catechol-O-methyltransferase and cytochrome P-450 1B1 polymorphisms and endometrial cancer risk: a meta-analysis. Teng Y et al. 2013 International journal of gynecological cancer
23408064 The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism. Klebe S et al. 2013 Journal of neurology, neurosurgery, and psychiatry
23421762 COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese. Wang Y et al. 2013 Genes, brain, and behavior
23429840 Prepulse inhibition of startle response: recent advances in human studies of psychiatric disease. Takahashi H et al. 2011 Clinical psychopharmacology and neuroscience
23440431 Association of the COMT Met¹⁵⁸ allele with trait impulsivity in healthy young adults. Soeiro-De-Souza MG et al. 2013 Molecular medicine reports
23459442 COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers. Herman AI et al. 2013 The pharmacogenomics journal
23598060 Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia. Liu X et al. 2013 Psychiatry research
23618651 Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depressive disorder. Seok JH et al. 2013 Neuroscience letters
23632726 Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome. Wachman EM et al. 2013 JAMA
23706899 Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder. Hopkins SC et al. 2013 Psychiatry research
23715639 The association between the catechol-O-methyltransferase Val108/158Met polymorphism and hyperactive-impulsive and inattentive symptoms in youth. Nikolac Perkovic M et al. 2013 Psychopharmacology
23728717 Common functional polymorphisms in SLC6A4 and COMT genes are associated with circadian phenotypes in a South American sample. Ojeda DA et al. 2014 Neurological sciences
23733030 Pharmacogenetics in major depression: a comprehensive meta-analysis. Niitsu T et al. 2013 Progress in neuro-psychopharmacology & biological psychiatry
23762769 Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599. Maria K et al. 2012 ISRN psychiatry
23766564 Pharmacogenetics of chronic pain and its treatment. Světlík S et al. 2013 Mediators of inflammation
23769684 Apathy is associated with a single-nucleotide polymorphism in a dopamine-related gene. Mitaki S et al. 2013 Neuroscience letters
23773341 An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans. Cargnin S et al. 2013 The journal of pain
23774690 Distribution of the Val108/158Met polymorphism of the COMT gene in healthy Mexican population. González-Castro TB et al. 2013 Gene
23785672 Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans. Ghisari M et al. 2013 International journal of circumpolar health
23793356 Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls. Falcone M et al. 2013 Neuropsychopharmacology
23808549 Candidate gene associations with withdrawn behavior. Rubin DH et al. 2013 Journal of child psychology and psychiatry, and allied disciplines
23818048 Gender effects of the COMT Val 158 Met genotype on verbal fluency in healthy adults. Soeiro-De-Souza MG et al. 2013 Molecular medicine reports
23856854 Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders. McCracken JT et al. 2014 The pharmacogenomics journal
23880798 No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women. Passarelli MN et al. 2014 Menopause (New York, N.Y.)
23910792 Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes. Zarchi O et al. 2013 Journal of psychiatric research
23922910 A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk. Kelly LE et al. 2013 PloS one
23927501 Why it is hard to find genes associated with social science traits: theoretical and empirical considerations. Chabris CF et al. 2013 American journal of public health
23928748 Impact of COMT genotype on serotonin-1A receptor binding investigated with PET. Baldinger P et al. 2014 Brain structure & function
23932573 Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort. Kukshal P et al. 2013 Journal of psychiatric research
23941313 Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. David SP et al. 2013 Addiction (Abingdon, England)
23946381 Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Ma X et al. 2014 Gut
23954148 The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism. Vinkers CH et al. 2013 Schizophrenia research
23963787 Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision. Bortsov AV et al. 2014 Neuromolecular medicine
24013564 Use of extremely short Förster resonance energy transfer probes in real-time polymerase chain reaction. Kutyavin IV et al. 2013 Nucleic acids research
24086514 Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. Beer B et al. 2013 PloS one
24118915 The interaction of early life experiences with COMT val158met affects anxiety sensitivity. Baumann C et al. 2013 Genes, brain, and behavior
24128936 PharmGKB summary: venlafaxine pathway. Sangkuhl K et al. 2014 Pharmacogenetics and genomics
24144248 Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load. Smith CT et al. 2014 Journal of cognitive neuroscience
24145376 Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans. Papaleo F et al. 2014 Molecular psychiatry
24178190 Influence of variation in the catechol-O-methyltransferase gene on the clinical outcome after lumbar spine surgery for one-level symptomatic disc disease: a report on 176 cases. Rut M et al. 2014 Acta neurochirurgica
24201053 Pharmacogenetics of OPRM1. Crist RC et al. 2014 Pharmacology, biochemistry, and behavior
24225542 Association of COMT val158met and DRD2 G>T genetic polymorphisms with individual differences in motor learning and performance in female young adults. Noohi F et al. 2014 Journal of neurophysiology
24274352 Green tea consumption and breast cancer risk in Japanese women: a case-control study. Iwasaki M et al. 2014 Nutrition and cancer
24290452 Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis. Fernández-de-las-Peñas C et al. 2013 The journal of pain
24319431 Mechanisms of antidepressant resistance. El-Hage W et al. 2013 Frontiers in pharmacology
24373005 Association analysis of the catechol-O-methyltransferase /methylenetetrahydrofolate reductase genes and cognition in late-onset depression. Wang X et al. 2014 Psychiatry and clinical neurosciences
24390676 COMT Associations with Disordered Gambling and Drinking Measures. Guillot CR et al. 2015 Journal of gambling studies
24407958 Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures. Bühler KM et al. 2014 Molecular genetics and genomics
24448899 Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype. Zhang Y et al. 2014 Psychopharmacology
24495967 Common polymorphisms in dopamine-related genes combine to produce a 'schizophrenia-like' prefrontal hypoactivity. Vercammen A et al. 2014 Translational psychiatry
24499375 Association of oxidative stress-related genes with idiopathic recurrent miscarriage. Khadzhieva MB et al. 2014 Free radical research
24508446 Gene×gene×gender interaction of BDNF and COMT genotypes associated with panic disorder. Konishi Y et al. 2014 Progress in neuro-psychopharmacology & biological psychiatry
24555772 Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression. Chiesa A et al. 2014 International journal of psychiatry in clinical practice
24589356 Association between genes, stressful childhood events and processing bias in depression vulnerable individuals. Vrijsen JN et al. 2014 Genes, brain, and behavior
24625311 Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults. Valomon A et al. 2014 Chronobiology international
24629213 Polymorphisms in phase I and phase II genes and breast cancer risk and relations to persistent organic pollutant exposure: a case-control study in Inuit women. Ghisari M et al. 2014 Environmental health
24656901 Factors affecting cognitive remediation response in schizophrenia: the role of COMT gene and antipsychotic treatment. Bosia M et al. 2014 Psychiatry research
24684248 Functional polymorphisms in COMT and SLC6A4 genes influence the prognosis of patients with medication overuse headache after withdrawal therapy. Cargnin S et al. 2014 European journal of neurology
24711381 Social disadvantage, genetic sensitivity, and children's telomere length. Mitchell C et al. 2014 Proceedings of the National Academy of Sciences of the United States of America
24755993 Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences? Bakker JM et al. 2014 Translational psychiatry
24782743 Association of COMT and COMT-DRD2 interaction with creative potential. Zhang S et al. 2014 Frontiers in human neuroscience
24819480 COMT gene and risk for Parkinson's disease: a systematic review and meta-analysis. Jiménez-Jiménez FJ et al. 2014 Pharmacogenetics and genomics
24842701 PRKCA polymorphism changes the neural basis of episodic remembering in healthy individuals. MacLeod CA et al. 2014 PloS one
24853458 Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects. Carmel M et al. 2014 Journal of psychiatric research
24860514 Gene-environment interactions in severe mental illness. Uher R et al. 2014 Frontiers in psychiatry
24862404 Exploring the indirect effects of catechol-O-methyltransferase (COMT) genotype on psychotic experiences through cognitive function and anxiety disorders in a large birth cohort of children. Niarchou M et al. 2014 American journal of medical genetics. Part B, Neuropsychiatric genetics
24881125 From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment. Fabbri C et al. 2014 Canadian journal of psychiatry. Revue canadienne de psychiatrie
24889756 Preliminary investigation of the influence of dopamine regulating genes on social working memory. Dumontheil I et al. 2014 Social neuroscience
24904231 A novel catechol-O-methyltransferase variant associated with human disc degeneration. Gruber HE et al. 2014 International journal of medical sciences
24904437 Gone to Pot - A Review of the Association between Cannabis and Psychosis. Radhakrishnan R et al. 2014 Frontiers in psychiatry
24937821 Vitiligo--part 1. Tarlé RG et al. 2014 Anais brasileiros de dermatologia
24944790 Screening for 392 polymorphisms in 141 pharmacogenes. Kim JY et al. 2014 Biomedical reports
24955500 Perceived stress during pregnancy and the catechol-O-methyltransferase (COMT) rs165599 polymorphism impacts on childhood IQ. Lamb YN et al. 2014 Cognition
24972245 The activity of catechol-O-methyltransferase (COMT) is not impaired by high doses of epigallocatechin-3-gallate (EGCG) in vivo. Lorenz M et al. 2014 European journal of pharmacology
24990354 Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring. Liu J et al. 2015 Metabolic brain disease
24996618 Host genetic factors predisposing to HIV-associated neurocognitive disorder. Kallianpur AR et al. 2014 Current HIV/AIDS reports
25012481 Association study of two steroid biosynthesis genes (COMT and CYP17) with Alzheimer's disease in the Italian population. Corbo RM et al. 2014 Journal of the neurological sciences
25017045 The neurobiological link between OCD and ADHD. Brem S et al. 2014 Attention deficit and hyperactivity disorders
25035343 Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease. Hall KT et al. 2014 Arteriosclerosis, thrombosis, and vascular biology
25040948 The design and methods of genetic studies on acute and chronic postoperative pain in patients after total knee replacement. Belfer I et al. 2014 Pain medicine (Malden, Mass.)
25045629 Is catechol-o-methyltransferase gene polymorphism a risk factor in the development of premenstrual syndrome? Deveci EO et al. 2014 Clinical and experimental reproductive medicine
25048416 Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children. Cote AT et al. 2015 The pharmacogenomics journal
25063767 Interactions Between Early Trauma and Catechol-O-Methyltransferase Genes on Inhibitory Deficits in Children With ADHD. Park S et al. 2017 Journal of attention disorders
25080285 Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study. Nombela C et al. 2014 Brain
25102390 Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease. Jhun E et al. 2014 Anesthesia and analgesia
25159270 Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility. Sulik MJ et al. 2015 Development and psychopathology
25184405 Subclinical psychotic experiences in healthy young adults: associations with stress and genetic predisposition. Bruenig D et al. 2014 Genetic testing and molecular biomarkers
25185591 Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain. Candiotti KA et al. 2014 Anesthesia and analgesia
25195915 The mediating effect of prefrontal asymmetry on the relationship between the COMT Val(158)Met SNP and trait consummatory positive affect. Katz AC et al. 2015 Cognition & emotion
25218601 Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain. Smith SB et al. 2014 Pain
25238062 The role of catechol-O-methyl transferase Val(108/158)Met polymorphism (rs4680) in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study. Hursel R et al. 2014 PloS one
25239657 Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. van Blitterswijk M et al. 2014 Molecular neurodegeneration
25266489 Genetic polymorphisms of VIP variants in the Tajik ethnic group of northwest China. Zhang J et al. 2014 BMC genetics
25280560 Association between Catechol-O-methyltransferase rs4680 (G>A) polymorphism and lung cancer risk. Tan X et al. 2014 Diagnostic pathology
25324626 Research in China on the molecular genetics of schizophrenia. Cui D et al. 2012 Shanghai archives of psychiatry
25325218 Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes. Radoeva PD et al. 2014 Psychiatric genetics
25365808 Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine-related loci. Gray JC et al. 2014 Brain and behavior
25491588 Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population. Shibata N et al. 2015 International journal of geriatric psychiatry
25495556 Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study. Villemonteix T et al. 2015 The world journal of biological psychiatry
25510197 Dopamine and cognitive control: sex-by-genotype interactions influence the capacity to switch attention. Gurvich C et al. 2015 Behavioural brain research
25515329 Genetic predictor of working memory and prefrontal function in women with HIV. Sundermann EE et al. 2015 Journal of neurovirology
25532715 COMT gene haplotypes are closely associated with postoperative fentanyl dose in patients. Zhang F et al. 2015 Anesthesia and analgesia
25545355 Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. O'Loughlin J et al. 2014 PloS one
25556215 Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children's intelligence in endemic fluorosis area in Tianjin, China. Zhang S et al. 2015 Toxicological sciences
25560469 COMT Val158Met and 5-HT1A-R -1019 C/G polymorphisms: effects on the negative symptom response to clozapine. Bosia M et al. 2015 Pharmacogenomics
25636089 [Polymorphisms of catechol-O-methyltransferase and monoamine oxidase B genes among Chinese patients with Parkinson's disease]. Hao H et al. 2015 Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
25658328 Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits. Banlaki Z et al. 2015 PloS one
25663728 A neurogenetics approach to defining differential susceptibility to institutional care. Brett ZH et al. 2015 International journal of behavioral development
25741868 Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Richards S et al. 2015 Genetics in medicine
25744938 A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder. Wang LJ et al. 2015 Scientific reports
25753458 Dopaminergic denervation severity depends on COMT Val158Met polymorphism in Parkinson's disease. Muellner J et al. 2015 Parkinsonism & related disorders
25805645 Polymorphism of the dopamine transporter type 1 gene modifies the treatment response in Parkinson's disease. Moreau C et al. 2015 Brain
25819021 A review of pharmacogenetic studies of substance-related disorders. Jones JD et al. 2015 Drug and alcohol dependence
25912540 Effect of polymorphisms of three genes mediating monoamine signalling on brain morphometry in schizophrenia and healthy subjects. Vijayakumari AA et al. 2015 Clinical psychopharmacology and neuroscience
25927430 Association of DRD3, COMT, and SLC6A4 Gene Polymorphisms with Type 2 Diabetes in Southern Chinese: A Hospital-Based Case-Control Study. Xiu L et al. 2015 Diabetes technology & therapeutics
25929431 Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study. De Marchis ML et al. 2015 The journal of headache and pain
25936248 Genetic Basis of the Relationship Between Reproduction and Longevity: A Study on Common Variants of Three Genes in Steroid Hormone Metabolism--CYP17, HSD17B1, and COMT. Scarabino D et al. 2015 Rejuvenation research
25948405 Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors? Currow DC et al. 2015 BMJ open
25960587 A Genetic Variant (COMT) Coding Dopaminergic Activity Predicts Personality Traits in Healthy Elderly. Kotyuk E et al. 2015 Personality and individual differences
25963335 Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy. Tan EC et al. 2016 The pharmacogenomics journal
25974322 Association of TMEM132D, COMT, and GABRA6 genotypes with cingulate, frontal cortex and hippocampal emotional processing in panic and major depressive disorder. Inoue A et al. 2015 International journal of psychiatry in clinical practice
25987236 Functional variants in CYP1B1, KRAS and MTHFR genes are associated with shorter telomere length in postmenopausal women. Cerne JZ et al. 2015 Mechanisms of ageing and development
26026741 Lack of association between COMT polymorphism rs4680 and risk of Alzheimer's disease in Asians: Evidence from a meta-analysis. Zhang G et al. 2015 Psychiatry research
26028545 COMT genotype, gambling activity, and cognition. Grant JE et al. 2015 Journal of psychiatric research
26044620 Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. Reyes-Gibby CC et al. 2015 BMC systems biology
26053146 Child exposure to serious life events, COMT, and aggression: Testing differential susceptibility theory. Hygen BW et al. 2015 Developmental psychology
26091847 Genetic polymorphisms of pharmacogenomic VIP variants in the Uygur population from northwestern China. Wang L et al. 2015 BMC genetics
26147675 Common Variants in LRP2 and COMT Genes Affect the Susceptibility of Gout in a Chinese Population. Dong Z et al. 2015 PloS one
26189450 Genetic Moderation of Stress Effects on Corticolimbic Circuitry. Bogdan R et al. 2016 Neuropsychopharmacology
26220612 Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes. MacKillop J et al. 2015 Psychopharmacology
26245713 Association of COMT and SLC6A3 polymorphisms with impulsivity, response inhibition and brain function. Kasparbauer AM et al. 2015 Cortex; a journal devoted to the study of the nervous system and behavior
26253436 Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis. Watanabe K et al. 2015 Psychiatry research
26260058 Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth. Christiaens I et al. 2015 BMC medical genetics
26272340 Polymorphism in COMT is associated with IgG3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome. Löbel M et al. 2015 Journal of translational medicine
26272535 The placebo effect: From concepts to genes. Colagiuri B et al. 2015 Neuroscience
26322144 <i>COMT</i> and <i>OPRM1</i> Genotype Associations with Daily Knee Pain Variability and Activity Induced Pain. Martire LM et al. 2016 Scandinavian journal of pain
26322220 A comprehensive meta-analysis of common genetic variants in autism spectrum conditions. Warrier V et al. 2015 Molecular autism
26345603 Predictors of heroin relapse: Personality traits, impulsivity, COMT gene Val158met polymorphism in a 5-year prospective study in Shanghai, China. Su H et al. 2015 American journal of medical genetics. Part B, Neuropsychiatric genetics
26362601 Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study. DeCarlo CA et al. 2016 The journals of gerontology. Series B, Psychological sciences and social sciences
26390831 Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways. Howe AS et al. 2016 Molecular psychiatry
26394291 Influence of Catechol-O-methyltransferase on Executive Functioning Longitudinally After Early Childhood Traumatic Brain Injury: Preliminary Findings. Kurowski BG et al. 2016 The Journal of head trauma rehabilitation
26483654 Linking unfounded beliefs to genetic dopamine availability. Schmack K et al. 2015 Frontiers in human neuroscience
26486601 Interaction Between Season of Birth and COMT Val158Met (rs4680) in ADHD in a Large Sample of Chinese Han Participants. Gao Q et al. 2018 Journal of attention disorders
26489634 Association of single nucleotide polymorphisms of ABCB1, OPRM1 and COMT with pain perception in cancer patients. Wang XS et al. 2015 Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
26508970 Association of the Catechol O-Methyltransferase Val158-Met Polymorphism and Reduced Interference Control in Korean Children with Attention-Deficit Hyperactivity Disorder. Park S et al. 2015 Psychiatry investigation
26543368 Epidemiological support for genetic variability at hypothalamic-pituitary-adrenal axis and serotonergic system as risk factors for major depression. Ching-López A et al. 2015 Neuropsychiatric disease and treatment
26555332 Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: a meta-analysis. Choi HD et al. 2015 Pharmacogenomics
26560848 The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder. Jin J et al. 2016 Genes, brain, and behavior
26572896 Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype. Spronk DB et al. 2016 Psychopharmacology
26580694 A Dopamine Pathway Gene Risk Score for Cognitive Recovery Following Traumatic Brain Injury: Methodological Considerations, Preliminary Findings, and Interactions With Sex. Myrga JM et al. 2016 The Journal of head trauma rehabilitation
26616111 Disorder-specific genetic factors in obsessive-compulsive disorder: A comprehensive meta-analysis. Taylor S et al. 2016 American journal of medical genetics. Part B, Neuropsychiatric genetics
26627480 Genetic predisposition to acute kidney injury--a systematic review. Vilander LM et al. 2015 BMC nephrology
26642826 Network-Dependent Modulation of COMT and DRD2 Polymorphisms in Healthy Young Adults. Zhao F et al. 2015 Scientific reports
26687156 Catechol-O-Methyltransferase Gene Polymorphisms in Specific Obsessive-Compulsive Disorder Patients' Subgroups. Melo-Felippe FB et al. 2016 Journal of molecular neuroscience
26724569 Catechol-O-methyltransferase gene variants may associate with negative symptom response and plasma concentrations of prolactin in schizophrenia after amisulpride treatment. Chen CY et al. 2016 Psychoneuroendocrinology
26745992 Catechol-O-Methyltransferase Val158Met Polymorphism and Clinical Response to Antipsychotic Treatment in Schizophrenia and Schizo-Affective Disorder Patients: a Meta-Analysis. Huang E et al. 2016 The international journal of neuropsychopharmacology
26746237 Attention deficit hyperactivity disorder: genetic association study in a cohort of Spanish children. Gomez-Sanchez CI et al. 2016 Behavioral and brain functions
26756273 Genetics of psychosis of Alzheimer disease. Shah C et al. 2017 American journal of medical genetics. Part B, Neuropsychiatric genetics
26803486 Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity. Wang M et al. 2016 Journal of neuroimmune pharmacology
26808641 Dopamine receptor D2 and catechol-O-methyltransferase gene polymorphisms associated with anorexia nervosa in Chinese Han population: DRD2 and COMT gene polymorphisms were associated with AN. Peng S et al. 2016 Neuroscience letters
26839669 The Influence of Genotype Polymorphism on Morphine Analgesic Effect for Postoperative Pain in Children. Lee MG et al. 2016 The Korean journal of pain
26849490 Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study. Park DJ et al. 2016 European journal of pain (London, England)
26858644 Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling. Chua EW et al. 2016 Frontiers in pharmacology
26902643 Human Genetic Variability Contributes to Postoperative Morphine Consumption. De Gregori M et al. 2016 The journal of pain
26917235 COMT Val158Met polymorphism influences the susceptibility to framing in decision-making: OFC-amygdala functional connectivity as a mediator. Gao X et al. 2016 Human brain mapping
26926883 Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies. Gluskin BS et al. 2016 Translational psychiatry
26954460 COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex. Dean B et al. 2016 American journal of medical genetics. Part B, Neuropsychiatric genetics
26986136 The Association Between Genetic Variants in the Dopaminergic System and Posttraumatic Stress Disorder: A Meta-Analysis. Li L et al. 2016 Medicine
26988620 No associations between five polymorphisms in COMT gene and migraine. Takigawa H et al. 2017 Acta neurologica Scandinavica
26989097 Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders. Coleman JR et al. 2016 The British journal of psychiatry
27004987 Interaction of COMT rs4680 and BDNF rs6265 polymorphisms on functional connectivity density of the left frontal eye field in healthy young adults. Li W et al. 2016 Human brain mapping
27015811 Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents. Kim KN et al. 2016 Environmental health
27020768 The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects. González-Castro TB et al. 2016 Neuromolecular medicine
27027462 Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation. Elens L et al. 2016 Therapeutic drug monitoring
27039372 Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder. Flowers SA et al. 2016 BMC psychology
27061127 Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model - An Explorative Study. Nielsen LM et al. 2016 Basic & clinical pharmacology & toxicology
27061230 The ABCB1, rs9282564, AG and TT Genotypes and the COMT, rs4680, AA Genotype are Less Frequent in Deceased Patients with Opioid Addiction than in Living Patients with Opioid Addiction. Christoffersen DJ et al. 2016 Basic & clinical pharmacology & toxicology
27074016 Polymorphisms of Estrogen Metabolism-Related Genes and Prostate Cancer Risk in Two Populations of African Ancestry. Brureau L et al. 2016 PloS one
27091610 COMT, BDNF, and DTNBP1 polymorphisms and cognitive functions in patients with brain tumors. Correa DD et al. 2016 Neuro-oncology
27103528 Association of genetic risk factors with cognitive decline: the PATH through life project. Andrews SJ et al. 2016 Neurobiology of aging
27138112 COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis. Corral-Frías NS et al. 2016 Genes, brain, and behavior
27166759 Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions. Yang J et al. 2016 Molecular psychiatry
27203226 The COMT rs4680 polymorphism and suicide attempt in rural Shandong, China. Sun SH et al. 2016 Psychiatric genetics
27217152 Attention-deficit hyperactivity disorder in adults: A systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies. Bonvicini C et al. 2016 Molecular psychiatry
27233804 Genetic polymorphisms of pharmacogenomic VIP variants in the Mongol of Northwestern China. Jin T et al. 2016 BMC genetics
27241058 COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review. Schacht JP et al. 2016 The pharmacogenomics journal
27247849 Genetic variation and cognitive dysfunction in opioid-treated patients with cancer. Kurita GP et al. 2016 Brain and behavior
27282867 Catechol-O-methyltransferase association with hemoglobin A1c. Hall KT et al. 2016 Metabolism
27322568 Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype. Narendran R et al. 2016 PloS one
27347613 Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study. Seib C et al. 2016 Genetic testing and molecular biomarkers
27375535 Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review. Taub DR et al. 2016 Frontiers in psychology
27446594 Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population. Goto A et al. 2016 Journal of pharmaceutical health care and sciences
27457818 Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome. Hall KT et al. 2016 The pharmacogenomics journal
27458023 Manic symptom severity correlates with COMT activity in the striatum: A post-mortem study. Bortolato M et al. 2017 The world journal of biological psychiatry
27521242 TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs. Xu Z et al. 2016 The international journal of neuropsychopharmacology
27610078 MAOA Influences the Trajectory of Attentional Development. Lundwall RA et al. 2016 Frontiers in human neuroscience
27642547 Genetic and Environmental Factors Associated with Cannabis Involvement. Bogdan R et al. 2016 Current addiction reports
27649267 Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain. Somogyi AA et al. 2016 Pain
27716216 The Anatomy to Genomics (ATG) Start Genetics medical school initiative: incorporating exome sequencing data from cadavers used for Anatomy instruction into the first year curriculum. Gerhard GS et al. 2016 BMC medical genomics
27721799 Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions. Mirkovic B et al. 2016 Frontiers in psychiatry
27743374 Associations between genetic risk, functional brain network organization and neuroticism. Servaas MN et al. 2017 Brain imaging and behavior
27757066 Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations. Eum S et al. 2016 Dialogues in clinical neuroscience
27780702 Catechol-O-methyltransferase gene polymorphism and vulvar pain in women with vulvodynia. Patanwala IY et al. 2017 American journal of obstetrics and gynecology
27883295 Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer. Sissung TM et al. 2016 Pharmacogenomics
27895608 Genetic Consideration of Schizotypal Traits: A Review. Walter EE et al. 2016 Frontiers in psychology
27903758 OPRM1 and COMT Gene-Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma. Khalil H et al. 2017 Biological research for nursing
27909454 Linkage and Association Analyses of Schizophrenia with Genetic Variations on Chromosome 22q11 in Koreans. Yoon SC et al. 2016 Psychiatry investigation
27964712 Genes associated with persistent lumbar radicular pain; a systematic review. Bjorland S et al. 2016 BMC musculoskeletal disorders
27974137 Health effects associated with measured levels of contaminants in the Arctic. Weihe P et al. 2016 International journal of circumpolar health
27983768 Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity. Wachman EM et al. 2017 The American journal on addictions
28049082 Catechol-O-methyltransferase Val(108/158)Met polymorphism affects fronto-limbic connectivity during emotional processing in bipolar disorder. Vai B et al. 2017 European psychiatry
28060209 Catechol-O-Methyltransferase Genotypes and Parenting Influence on Long-Term Executive Functioning After Moderate to Severe Early Childhood Traumatic Brain Injury: An Exploratory Study. Kurowski BG et al. 2017 The Journal of head trauma rehabilitation
28078547 ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults. Xu Q et al. 2018 Brain imaging and behavior
28084056 Genetic Influences of OPRM1, OPRD1 and COMT on Morphine Analgesia in a Multi-Modal, Multi-Tissue Human Experimental Pain Model. Nielsen LM et al. 2017 Basic & clinical pharmacology & toxicology
28085950 Impact of DRD2/ANKK1 and COMT Polymorphisms on Attention and Cognitive Functions in Schizophrenia. Nkam I et al. 2017 PloS one
28089731 Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine. Sutherland HG et al. 2017 Gene
28096880 Genetic Polymorphism of 1019C/G (rs6295) Promoter of Serotonin 1A Receptor and Catechol-O-Methyltransferase in Panic Disorder. Watanabe T et al. 2017 Psychiatry investigation
28102561 Stressful life events and catechol-O-methyl-transferase (COMT) gene in bipolar disorder. Hosang GM et al. 2017 Depression and anxiety
28127926 5-HTTLPR and DISC1 risk genotypes for elevated PTSD symptoms in US military veterans. Young KA et al. 2017 World psychiatry
28157646 Polymorphism in xenobiotic and estrogen metabolizing genes, exposure to perfluorinated compounds and subsequent breast cancer risk: A nested case-control study in the Danish National Birth Cohort. Ghisari M et al. 2017 Environmental research
28178648 Polymorphisms of ESR1, UGT1A1, HCN1, MAP3K1 and CYP2B6 are associated with the prognosis of hormone receptor-positive early breast cancer. Kuo SH et al. 2017 Oncotarget
28223811 Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and <i>COMT</i> gene. Tang X et al. 2017 Neuropsychiatric disease and treatment
28235603 Val158Met polymorphism in the COMT gene is associated with hypersomnia and mental health-related quality of life in a Colombian sample. Jiménez KM et al. 2017 Neuroscience letters
28253266 Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis. Wu X et al. 2017 PloS one
28259860 Potential salivary biomarkers and their genetic effects in a pilot study of adolescent boys with externalizing problems. Angyal N et al. 2016 Neuropsychopharmacologia Hungarica
28273278 Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls. Matsuzaka CT et al. 2017 Revista brasileira de psiquiatria (Sao Paulo, Brazil
28321040 Whole exome sequencing detects variants of genes that mediate response to anticancer drugs. Ohnami S et al. 2017 The Journal of toxicological sciences
28388928 SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature. Bokharaeian B et al. 2017 Journal of biomedical semantics
28399184 Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease. Huertas I et al. 2017 PloS one
28429405 Child body mass index, genotype and parenting in the prediction of restrictive feeding. Bost KK et al. 2018 Pediatric obesity
28446500 Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylation. De la Torre R et al. 2017 The American journal of clinical nutrition
28451382 Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson's disease. Xiao Q et al. 2017 Translational neurodegeneration
28452825 Joint Impact of Early Life Adversity and COMT Val158Met (rs4680) Genotypes on the Adult Cortisol Response to Psychological Stress. Lovallo WR et al. 2017 Psychosomatic medicine
28462386 Association of Variants of Arginine Vasopressin and Arginine Vasopressin Receptor 1A With Severe Acetaminophen Liver Injury. Randesi M et al. 2017 Cellular and molecular gastroenterology and hepatology
28472995 Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men. Ou WC et al. 2017 Behavioral and brain functions
28533660 Genes, emotions and gut microbiota: The next frontier for the gastroenterologist. Panduro A et al. 2017 World journal of gastroenterology
28534260 Pharmacogenetics of Cannabinoids. Hryhorowicz S et al. 2018 European journal of drug metabolism and pharmacokinetics
28582665 The influence of CHRNA4, COMT, and maternal sensitivity on orienting and executive attention in 6-month-old infants. Quan J et al. 2017 Brain and cognition
28610409 Impact of Catechol-O-Methyltransferase Val 158Met (rs4680) Polymorphism on Breast Cancer Susceptibility in Asian Population Rai V et al. 2017 Asian Pacific journal of cancer prevention
28614354 Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD. O'Donnell KJ et al. 2017 PloS one
28627776 The Catechol-O-methyltransferase Val(108/158)Met Genetic Polymorphism cannot be Recommended as a Biomarker for the Prediction of Venlafaxine Efficacy in Patients Treated in Psychiatric Settings. Taranu A et al. 2017 Basic & clinical pharmacology & toxicology
28629779 Are dopaminergic genotypes risk factors for eating behavior and obesity in adults? Avsar O et al. 2017 Neuroscience letters
28635556 Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders. Carrà G et al. 2017 Nordic journal of psychiatry
28648906 COMT genotype is differentially associated with single trial variability of ERPs as a function of memory type. Rostami HN et al. 2017 Biological psychology
28656735 An analysis of genetic association in opioid dependence susceptibility. Nagaya D et al. 2018 Journal of clinical pharmacy and therapeutics
28665765 The association between COMT rs4680 and 5-HTTLPR genotypes and concussion history in South African rugby union players. Mc Fie S et al. 2018 Journal of sports sciences
28694222 Effects of single genetic variants and polygenic obesity risk scores on disordered eating in adolescents - The HUNT study. Sardahaee FS et al. 2017 Appetite
28707072 Catechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer's Disease. Chang CC et al. 2018 Molecular neurobiology
28728097 Nonlinear modulation of interacting between COMT and depression on brain function. Gong L et al. 2017 European psychiatry
28740224 Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson's disease. Lin CH et al. 2017 Scientific reports
28744152 Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder. Zastrozhin MS et al. 2017 Pharmacogenomics and personalized medicine
28746172 A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers. Xu J et al. 2017 Medicine
28822116 Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review. Misiak B et al. 2018 Molecular neurobiology
28844929 Distribution, properties, and inhibitor sensitivity of zebrafish catechol-O-methyl transferases (COMT). Semenova S et al. 2017 Biochemical pharmacology
28871191 Pharmacogenetics of methylphenidate in childhood attention-deficit/hyperactivity disorder: long-term effects. Gomez-Sanchez CI et al. 2017 Scientific reports
28887105 The significance of polymorphism and expression of oestrogen metabolism-related genes in Chinese women with premature ovarian insufficiency. Qin C et al. 2017 Reproductive biomedicine online
28900390 Genetically-Driven Enhancement of Dopaminergic Transmission Affects Moral Acceptability in Females but Not in Males: A Pilot Study. Pellegrini S et al. 2017 Frontiers in behavioral neuroscience
28927418 A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson's disease. Guin D et al. 2017 BMC medical genomics
28928973 Prospective replication study implicates the catechol-O-methyltransferase Val<sup>158</sup>Met polymorphism as a biomarker for the response to morphine in patients with cancer. Matsuoka H et al. 2017 Biomedical reports
28948081 Sex-specific effects of <i>COMT</i> Val158Met polymorphism on corpus callosum structure: A whole-brain diffusion-weighted imaging study. El-Hage W et al. 2017 Brain and behavior
28968343 Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia. Forsberg JT et al. 2018 Pain
29020372 Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors. Bhakta SG et al. 2017 The international journal of neuropsychopharmacology
29048744 Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems. Yeung EW et al. 2017 Alcoholism, clinical and experimental research
29091826 Genotypic and haplotypic associations of catechol-O-methyltransferase (COMT) rs4680 and rs4818 with salivary cortisol in patients with schizophrenia. Hirasawa-Fujita M et al. 2018 Psychiatry research
29135816 Dopaminergic Genetic Variants and Voluntary Externally Paced Exercise Behavior. VAN DER Mee DJ et al. 2018 Medicine and science in sports and exercise
29154367 Effects of Amphetamine on Sensorimotor Gating and Neurocognition in Antipsychotic-Medicated Schizophrenia Patients. Swerdlow NR et al. 2018 Neuropsychopharmacology
29193749 Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years. Borobia AM et al. 2018 Clinical and translational science
29195501 COMT genotype and non-recovery after a whiplash injury in a Northern European population. Rydman E et al. 2017 BMC musculoskeletal disorders
29198511 Preliminary Evidence for an Association Between Variants of the Catechol-O-Methyltransferase (COMT) Gene and Premature Ejaculation. Jern P et al. 2017 The journal of sexual medicine
29201551 Investigation of the <i>COMT</i> Val158Met variant association with age of onset of psychosis, adjusting for cannabis use. Lodhi RJ et al. 2017 Brain and behavior
29225702 The influence of dopamine-beta-hydroxylase and catechol <i>O</i>-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus. Bozek T et al. 2017 Diabetology & metabolic syndrome
29230023 Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD. Myer NM et al. 2018 Molecular psychiatry
29247072 Vascular and dopaminergic contributors to mild parkinsonian signs in older adults. Rosso AL et al. 2018 Neurology
29249680 Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease. Miller NS et al. 2018 Parkinsonism & related disorders
29255361 Potential link between genetic polymorphisms of <i>catechol-O-methyltransferase</i> and dopamine receptors and treatment efficacy of risperidone on schizophrenia. Han J et al. 2017 Neuropsychiatric disease and treatment
29259946 Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment. Chatti I et al. 2017 Iranian journal of public health
29270116 COMT Val<sup>158</sup>Met Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function. Elton A et al. 2017 Frontiers in human neuroscience
29287625 Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response. Quednow BB et al. 2018 Schizophrenia research
29289372 Childhood Abuse Experiences and the COMT and MTHFR Genetic Variants Associated With Male Sexual Orientation in the Han Chinese Populations: A Case-Control Study. Qin JB et al. 2018 The journal of sexual medicine
29325115 Fast sleep spindle density is associated with rs4680 (Val108/158Met) genotype of catechol-O-methyltransferase (COMT). Schilling C et al. 2018 Sleep
29326607 <i>CYP1A1</i> Ile462Val Polymorphism Is Associated with Cervical Cancer Risk in Caucasians Not Asians: A Meta-Analysis. Wang LN et al. 2017 Frontiers in physiology
29330410 The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders. Bernegger A et al. 2018 Scientific reports
29331705 Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study. Koike S et al. 2018 Journal of affective disorders
29351172 Systematic review and meta-analysis of genetic risk factors for neuropathic pain. Veluchamy A et al. 2018 Pain
29368490 Catechol-oxide-methyltransferase (COMT rs4680:G&gt;A) gene polymorphism does not affect analgesics’ demand after elective hip replaceme. Białecka M et al. 2016 Genetika
29426301 The COMT-polymorphism is not associated with the incidence of acute kidney injury after cardiac surgery - a prospective cohort study. Oezkur M et al. 2018 BMC nephrology
29429137 COMT and GAD1 gene polymorphisms are associated with impaired antisaccade task performance in schizophrenic patients. Kirenskaya AV et al. 2018 European archives of psychiatry and clinical neuroscience
29439855 Catechol-O-methyltransferase (COMT) genetic variants are associated with cognitive decline in patients with Parkinson's disease. Lin CH et al. 2018 Parkinsonism & related disorders
29455339 Analysis of COMT Val158Met polymorphisms and methylation in Chinese male schizophrenia patients with homicidal behavior. Hu Y et al. 2018 International journal of legal medicine
29474345 Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study. Aubrun F et al. 2018 European journal of anaesthesiology
29510000 Genetic Variations, Exposure to Persistent Organic Pollutants and Breast Cancer Risk - A Greenlandic Case-Control Study. Wielsøe M et al. 2018 Basic & clinical pharmacology & toxicology
29550002 Pulp Sensitivity: Influence of Sex, Psychosocial Variables, COMT Gene, and Chronic Facial Pain. Mladenovic I et al. 2018 Journal of endodontics
29559020 Gene polymorphisms and response to transcranial direct current stimulation for auditory verbal hallucinations in schizophrenia. Chhabra H et al. 2018 Acta neuropsychiatrica
29559808 Association of genetic variation in <i>COMT</i> gene with pain related to sickle cell disease in patients from the walk-PHaSST study. Zhang Y et al. 2018 Journal of pain research
29574383 Interplay between COMT Val158Met, childhood adversities and sex in predicting panic pathology: Findings from a general population sample. Asselmann E et al. 2018 Journal of affective disorders
29578580 MAO-B and COMT Genetic Variations Associated With Levodopa Treatment Response in Patients With Parkinson's Disease. Sampaio TF et al. 2018 Journal of clinical pharmacology
29634613 Association between COMT gene polymorphisms, clinical symptoms, and cognitive functions in Han Chinese patients with schizophrenia. Sun Z et al. 2018 Psychiatric genetics
29677196 Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition. Crum AJ et al. 2018 PloS one
29684863 Psychological and genetic risk factors associated with suicidal behavior in Korean patients with mood disorders. Choi HY et al. 2018 Journal of affective disorders
29760667 A <i>DRD2/ANNK1</i>-<i>COMT</i> Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese. Zhang K et al. 2018 Frontiers in psychiatry
29912452 Genetic Predictors of Response to Acupuncture for Aromatase Inhibitor-Associated Arthralgia Among Breast Cancer Survivors. Genovese TJ et al. 2019 Pain medicine (Malden, Mass.)
29941295 Beneficial and adverse effects of antipsychotic medication on cognitive flexibility are related to COMT genotype in first episode psychosis. Nelson CLM et al. 2018 Schizophrenia research
29950847 <i>COMT</i> Val 108/158 Met polymorphism and treatment response to aripiprazole in patients with acute schizophrenia. Kaneko H et al. 2018 Neuropsychiatric disease and treatment
29992684 A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults. Kim J et al. 2018 The American journal on addictions
30011860 Potential Impact of <i>COMT-rs4680 G &gt; A</i> Gene Polymorphism in Coronary Artery Disease. Mir R et al. 2018 Journal of cardiovascular development and disease
30018555 Haplotypic and Genotypic Association of Catechol-<i>O</i>-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia. Sagud M et al. 2018 Frontiers in pharmacology
30027496 Dopamine, time perception, and future time perspective. Mitchell JM et al. 2018 Psychopharmacology
30041166 Temperament and Character Inventory in Bipolar Disorder versus Healthy Controls and Modulatory Effects of 3 Key Functional Gene Variants. Porcelli S et al. 2017 Neuropsychobiology
30093869 Biological Predictors of Clozapine Response: A Systematic Review. Samanaite R et al. 2018 Frontiers in psychiatry
30123371 Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout. Zhu W et al. 2018 The open rheumatology journal
30127727 The COMT Val158Met Polymorphism and Reaction to a Transgression: Findings of Genetic Associations in Both Chinese and German Samples. Sindermann C et al. 2018 Frontiers in behavioral neuroscience
30130297 The opioid receptor mu 1 (OPRM1) rs1799971 and catechol-O-methyltransferase (COMT) rs4680 as genetic markers for placebo analgesia. Aslaksen PM et al. 2018 Pain
30137607 Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC]). Park JY et al. 2019 Translational behavioral medicine
30139393 Selective role for the COMT polymorphism in a trans-diagnostic compulsivity phenotype. Chamberlain SR et al. 2018 Psychological medicine
30178121 Neuroplasticity, Neurotransmission and Brain-Related Genes in Major Depression and Bipolar Disorder: Focus on Treatment Outcomes in an Asiatic Sample. Calabrò M et al. 2018 Advances in therapy
30211780 Associations of catechol-O-methyltransferase (rs4680) single nucleotide polymorphisms with opioid use and dose among adults with chronic pain. Hooten WM et al. 2019 Pain
30216543 Functional monoamine oxidase B gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson's disease. Löhle M et al. 2018 Movement disorders
30218069 Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex. Parkin GM et al. 2018 Journal of human genetics
30234521 Influences of COMT rs4680 and OPRM1 rs1799971 Polymorphisms on Chronic Postsurgical Pain, Acute Pain, and Analgesic Consumption After Elective Cesarean Delivery. Wang L et al. 2019 The Clinical journal of pain
30300332 Effects of COMT polymorphism on the cortical processing of vocal pitch regulation. Zhang S et al. 2018 Neuroreport
30342271 Frontoparietal cortical thickness mediates the effect of COMT Val<sup>158</sup>Met polymorphism on age-associated executive function. Miranda GG et al. 2019 Neurobiology of aging
30402947 The COMT Val<sup>158</sup> Met polymorphism does not modulate the after-effect of tDCS on working memory. Jongkees BJ et al. 2019 The European journal of neuroscience
30408108 Vulnerable combinations of functional dopaminergic polymorphisms to late-onset treatment resistant schizophrenia. Oishi K et al. 2018 PloS one
30424994 The Association Between C-Reactive Protein and Postoperative Delirium Differs by Catechol-O-Methyltransferase Genotype. Vasunilashorn SM et al. 2019 The American journal of geriatric psychiatry
30461653 Association between polymorphisms in estrogen metabolism genes and breast cancer development in Chinese women: A prospective case-control study. Qiu J et al. 2018 Medicine
30481348 Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine. Fernández-de-Las-Peñas C et al. 2019 Pain medicine (Malden, Mass.)
30486733 Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers. D'Agnelli S et al. 2019 Molecular pain
30592275 Pain polymorphisms and opioids: An evidence based review. Vieira CMP et al. 2019 Molecular medicine reports
30597299 A gender-specific COMT haplotype contributes to risk modulation rather than disease severity of major depressive disorder in a Chinese population. Chao JK et al. 2019 Journal of affective disorders
30608422 Analysis of the relationship between COMT polymorphisms and endometriosis susceptibility. Zhai J et al. 2019 Medicine
30614828 Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache. Fernández-de-Las-Peñas C et al. 2019 The Clinical journal of pain
30624689 COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials. Hall KT et al. 2019 Journal of the National Cancer Institute
30628551 The influence of Val158Met COMT on physiological stress responsivity. Serrano JM et al. 2019 Stress (Amsterdam, Netherlands)
30704436 Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review. Lucenteforte E et al. 2019 BMC cancer
30709768 Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18 months. Chau CMY et al. 2019 EBioMedicine
30719257 Genetic Variations of <i>DAOA</i> (rs947267 and rs3918342) and <i>COMT</i> Genes (rs165599 and rs4680) in Schizophrenia and Bipolar I Disorder. Ahmadi L et al. 2018 Basic and clinical neuroscience
30742958 Both Val158Met Polymorphism of Catechol-O-Methyltransferase Gene and Menstrual Cycle Affect Prepulse Inhibition but Not Attentional Modulation of Prepulse Inhibition in Younger-Adult Females. Wu C et al. 2019 Neuroscience
30790653 Usefulness of COMT gene polymorphisms in North African populations. Boussetta S et al. 2019 Gene
30822160 Association of COMT gene variability with pain intensity in patients after total hip replacement. Machoy-Mokrzyńska A et al. 2019 Scandinavian journal of clinical and laboratory investigation
30840133 Association of GA genotype of SNP rs4680 in COMT gene with psoriasis. Sobolev V et al. 2019 Archives of dermatological research
30852803 Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms. Cui L et al. 2019 Neuroscience bulletin
30886988 Association of Catechol-<i>O</i>-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients. Lee C et al. 2018 BMC rheumatology
30887472 [The Association between the Extended Psychosis Phenotype and COMT val158met and BDNF val66met polymorphisms]. Binbay T et al. 2018 Turk psikiyatri dergisi = Turkish journal of psychiatry
30909076 BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy. Doherty C et al. 2019 Epilepsy & behavior
30954919 Age-specific associations among functional COMT Val<sup>158</sup>Met polymorphism, resting parasympathetic nervous control and generalized anxiety disorder. Chang HA et al. 2019 Psychoneuroendocrinology
31023072 Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms. Knisely MR et al. 2019 Biological research for nursing
31041874 Effect of catechol-O-methyltransferase (rs4680) single-nucleotide polymorphism on opioid-induced hyperalgesia in adults with chronic pain. Hooten WM et al. 2019 Molecular pain
31072614 The lack of association between COMT rs4680 polymorphism and symptomatic remission to olanzapine monotherapy in male schizophrenic patients: A longitudinal study. Zivkovic M et al. 2019 Psychiatry research
31085105 Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management. Yang GS et al. 2019 Seminars in oncology nursing
31096213 Alzheimer's Disease and Neurotransmission Gene Variants: Focus on Their Effects on Psychiatric Comorbidities and Inflammatory Parameters. Porcelli S et al. 2019 Neuropsychobiology
31129315 Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain. Chidambaran V et al. 2020 The journal of pain
31137904 Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity. Crocco P et al. 2019 Genes
31142902 Catechol-O-Methyltransferase Val158Met and brain-derived neurotrophic factor Val66Met gene polymorphisms in paraphilic sexual offenders. Cengiz M et al. 2019 Indian journal of psychiatry
31150143 Early-Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes. Lovallo WR et al. 2019 Alcoholism, clinical and experimental research
31159911 Problematic internet use: an exploration of associations between cognition and COMT rs4818, rs4680 haplotypes. Ioannidis K et al. 2020 CNS spectrums
31187152 Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans. Ranganathan M et al. 2019 Psychopharmacology
31192519 Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation. Moses TEH et al. 2020 Addiction biology
31239688 COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder. Otsuka Y et al. 2019 Neuropsychiatric disease and treatment
31269327 Genetic Contribution in Low Back Pain: A Prospective Genetic Association Study. Margarit C et al. 2019 Pain practice
31289926 Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians. Avinun R et al. 2020 European archives of psychiatry and clinical neuroscience
31291232 The Association of Catechol-O-Methyl-Transferase and Interleukin 6 Gene Polymorphisms with Posttraumatic Stress Disorder. Haxhibeqiri V et al. 2019 Psychiatria Danubina
31303260 Which Dopamine Polymorphisms Are Functional? Systematic Review and Meta-analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1, and VMAT2. Tunbridge EM et al. 2019 Biological psychiatry
31335650 OPRM1 rs1799971, COMT rs4680, and FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia. Colloca L et al. 2019 Pain
31372986 Relations between catechol-O-methyltransferase Val158Met genotype and inhibitory control development in childhood. Bowers ME et al. 2020 Developmental psychobiology
31493434 Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone. Jones JD et al. 2019 Pharmacology, biochemistry, and behavior
31552390 Placebo effects and the molecular biological components involved. Cai L et al. 2019 General psychiatry
31555452 <i>BDNF</i>, <i>COMT</i>, and <i>DRD2</i> polymorphisms and ability to return to work in adult patients with low- and high-grade glioma. Altshuler DB et al. 2019 Neuro-oncology practice
31559529 Influence of dopamine-related genes on craving, impulsivity, and aggressiveness in Korean males with alcohol use disorder. Park CI et al. 2021 European archives of psychiatry and clinical neuroscience
31586564 The potential impact of COMT gene variants on dopamine regulation and phenotypic traits of ASD patients. Esmaiel NN et al. 2020 Behavioural brain research
31661578 Effects of genotype on TENS effectiveness in controlling knee pain in persons with mild to moderate osteoarthritis. Govil M et al. 2020 European journal of pain (London, England)
31673237 Association study of the functional Catechol-O-Methyltranferase (COMT) Val<sup>158</sup>Met polymorphism on executive cognitive function in a Thai sample. Khanthiyong B et al. 2019 International journal of medical sciences
31721892 Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial. Brunoni AR et al. 2020 Revista brasileira de psiquiatria (Sao Paulo, Brazil
31744450 Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine. Abijo T et al. 2020 Current neuropharmacology
31771069 Relationships of Cerebrospinal Fluid Alzheimer's Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms. Babić Leko M et al. 2020 Journal of Alzheimer's disease
31798476 Association of rs4680 <i>COMT</i>, rs6280 <i>DRD3</i>, and rs7322347 <i>5HT2A</i> With Clinical Features of Youth-Onset Schizophrenia. Morozova A et al. 2019 Frontiers in psychiatry
31806881 OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study. Ho KWD et al. 2020 The pharmacogenomics journal
31838976 Catechol-O-Methyltransferase and Cardiovascular Disease: MESA. Hall KT et al. 2019 Journal of the American Heart Association
31874497 [Effect of opioid-related gene polymorphisms on patients with high-dose opioid-tolerant cancer pain]. Xie GL et al. 2019 Zhonghua yi xue za zhi
31879835 Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis. Kumar P et al. 2020 Metabolic brain disease
31889426 Effects of traumatic life events, cognitive biases and variation in dopaminergic genes on psychosis proneness. Kotowicz K et al. 2021 Early intervention in psychiatry
31917897 Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training-related prefrontal plasticity. Zhao W et al. 2020 Brain and behavior
31960101 Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex. Dean B et al. 2020 Experimental brain research
31972309 Association between COMT gene Val108/158Met and antidepressive treatment response: A meta-analysis. Tang Z et al. 2020 Gene
32022467 Gene polymorphisms and motor levodopa-induced complications in Parkinson's disease. Michałowska M et al. 2020 Brain and behavior
32024434 COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity. Xu F et al. 2020 Molecular pain
32034175 COMT-Polymorphisms Modulated Functional Profile of the Fusiform Face Area Contributes to Face-Specific Recognition Ability. Wu C et al. 2020 Scientific reports
32057830 Interaction of COMT and KIBRA modulates the association between hippocampal structure and episodic memory performance in healthy young adults. Wang J et al. 2020 Behavioural brain research
32066722 Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child. Qi R et al. 2020 Translational psychiatry
32071497 Evaluation of COMT Gene rs4680 Polymorphism as a Risk Factor for Endometrial Cancer. Kumar P et al. 2020 Indian journal of clinical biochemistry
32079998 Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain. Baumbauer KM et al. 2020 The Clinical journal of pain
32132825 The "Warrior" COMT Val/Met Genotype Occurs in Greater Frequencies in Mixed Martial Arts Fighters Relative to Controls. Tartar JL et al. 2020 Journal of sports science & medicine
32149782 Sex Bias and Genotype Influence on Opioid Safety Profile in Chronic Low Back Pain. Margarit C et al. 2020 The Clinical journal of pain
32185238 Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia. Chen A et al. 2020 Journal of immunology research
32230800 Influence of Genetic Variation in <i>COMT</i> on Cisplatin-Induced Nephrotoxicity in Cancer Patients. Agema BC et al. 2020 Genes
32265697 Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia. Cao M et al. 2020 Frontiers in pharmacology
32306439 The influence of COMT rs4680 on functional connectivity in healthy adults: A systematic review. Morris KA et al. 2020 The European journal of neuroscience
32326111 Role of Genetic Variations in the Hepatic Handling of Drugs. Marin JJG et al. 2020 International journal of molecular sciences
32367059 Genetic basis of sleep bruxism and sleep apnea-response to a medical puzzle. Wieckiewicz M et al. 2020 Scientific reports
32398646 Do AKT1, COMT and FAAH influence reports of acute cannabis intoxication experiences in patients with first episode psychosis, controls and young adult cannabis users? Hindocha C et al. 2020 Translational psychiatry
32407152 Association of <i>COMT</i> Gene Polymorphisms with Response to Methadone Maintenance Treatment Among Chinese Opioid-Dependent Patients. Duan L et al. 2020 Genetic testing and molecular biomarkers
32433545 Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia. Tao R et al. 2020 Translational psychiatry
32457675 After the Honeymoon: Neural and Genetic Correlates of Romantic Love in Newlywed Marriages. Acevedo BP et al. 2020 Frontiers in psychology
32461926 Genotyping on blood and buccal cells using loop-mediated isothermal amplification in healthy humans. Drogou C et al. 2020 Biotechnology reports (Amsterdam, Netherlands)
32483134 The atorvastatin metabolic phenotype shift is influenced by interaction of drug-transporter polymorphisms in Mexican population: results of a randomized trial. León-Cachón RBR et al. 2020 Scientific reports
32525059 Genetic underpinnings of schizophrenia-related electroencephalographical intermediate phenotypes: A systematic review and meta-analysis. Hederih J et al. 2021 Progress in neuro-psychopharmacology & biological psychiatry
32533012 Genetic variations in catechol-O-methyltransferase gene are associated with levodopa response variability in Chinese patients with Parkinson's disease. Zhao C et al. 2020 Scientific reports
32572118 Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia. Nikolac Perkovic M et al. 2020 Scientific reports
32576619 Effects of <i>TPH2</i> gene variation and childhood trauma on the clinical and circuit-level phenotype of functional movement disorders. Spagnolo PA et al. 2020 Journal of neurology, neurosurgery, and psychiatry
32618128 Interaction between catechol-O-methyltransferase polymorphism and childhood trauma in suicidal ideation of patients with post-traumatic stress disorder. Kwon A et al. 2020 Brain and behavior
32623490 Genetic risks of schizophrenia identified in a matched case-control study. Oishi K et al. 2021 European archives of psychiatry and clinical neuroscience
32662357 Evaluation of COMT (rs4680), CNR2 (rs2501432), CNR2 (rs2229579), UCP2 (rs659366), and IL-17 (rs763780) gene variants in synthetic cannabinoid use disorder patients. Pehlivan S et al. 2020 Journal of addictive diseases
32692209 No association between the COMT Val158Met polymorphism and cognitive training response in healthy Shanghai community-dwelling elderly individuals. Feng W et al. 2020 Annals of palliative medicine
32723321 The association between serotonin-related gene polymorphisms and susceptibility and early sertraline response in patients with panic disorder. Zou Z et al. 2020 BMC psychiatry
32744066 A meta-analysis and <i>in silico</i> analysis of polymorphic variants conferring breast cancer risk in the Indian subcontinent. Sengupta D et al. 2020 Future oncology (London, England)
32772383 Opioid and Dopamine Genes Interact to Predict Naltrexone Response in a Randomized Alcohol Use Disorder Clinical Trial. Anton RF et al. 2020 Alcoholism, clinical and experimental research
32782694 The association of catechol-O-methyltransferase (COMT) rs4680 polymorphisms and generalized anxiety disorder in the Chinese Han population. He Q et al. 2020 International journal of clinical and experimental pathology
32822765 The role of COMT polymorphism in modulation of prefrontal activity during verbal fluency in bipolar disorder. Devrimci-Ozguven H et al. 2020 Neuroscience letters
32828797 Lack of association of common polymorphisms linked to empathic behavior with self-reported trait empathy in healthy volunteers. Huetter FK et al. 2020 Hormones and behavior
32829984 Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives. Hochberger WC et al. 2020 Schizophrenia research
32879833 Warriors, Worriers, and COVID-19: An Exploratory Study of the Catechol O-Methyltransferase Val158Met Polymorphism Across Populations. Rajkumar RP et al. 2020 Cureus
32889058 Epistatic effect of Ankyrin repeat and kinase domain containing 1 - Dopamine receptor D2 and catechol-o-methyltransferase single nucleotide polymorphisms on the risk for hazardous use of alcohol in Lithuanian population. Kaminskaite M et al. 2021 Gene
32931693 The effect of rs1076560 (DRD2) and rs4680 (COMT) on tardive dyskinesia and cognition in schizophrenia subjects. Punchaichira TJ et al. 2020 Psychiatric genetics
32974928 The COMT rs4680 polymorphism, family functioning and preschoolers' attentional control indexed by intraindividual reaction time variability. Zhang Y et al. 2021 Developmental psychobiology
32976278 Correlation Between the Warrior/Worrier Gene on Post Burn Pruritus and Scarring: A Prospective Cohort Study. Oh J et al. 2022 Annals of surgery
32985495 Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression. Li W et al. 2020 Medical science monitor
33013295 Contribution of Five Functional Loci of Dopamine Metabolism-Related Genes to Parkinson's Disease and Multiple System Atrophy in a Chinese Population. Chen Y et al. 2020 Frontiers in neuroscience
33040669 Genetics of human startle reactivity: A systematic review to acquire targets for an anxiety endophenotype. Tomasi J et al. 2021 The world journal of biological psychiatry
33043988 Catechol-O-Methyltransferase Genotype, Frailty, and Gait Speed in a Biracial Cohort of Older Adults. Mance S et al. 2021 Journal of the American Geriatrics Society
33093598 Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism. Senek M et al. 2020 Scientific reports
33100205 Association Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis. Ma J et al. 2021 Current neuropharmacology
33108341 The association between selected genetic variants and individual differences in experimental pain. Lie MU et al. 2021 Scandinavian journal of pain
33127070 The interactive effect of genetic polymorphisms of IL-10 and COMT on cognitive function in schizophrenia. Wang J et al. 2021 Journal of psychiatric research
33154520 A review of the existing literature on buprenorphine pharmacogenomics. Meaden CW et al. 2021 The pharmacogenomics journal
33250838 Polymorphism of the Dopa-Decarboxylase Gene Modifies the Motor Response to Levodopa in Chinese Patients With Parkinson's Disease. Li L et al. 2020 Frontiers in neurology
33262486 Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters. 2020 European journal of human genetics
33263843 Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study). Ivanova TI et al. 2020 Bulletin of experimental biology and medicine
33278020 Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics. Koller D et al. 2021 Advances in therapy
33282008 Lack of Association between rs4680 Polymorphism in Catechol-O-Methyltransferase Gene and Alcohol Use Disorder: A Meta-Analysis. Jin XR et al. 2020 Disease markers
33303340 OXTR rs53576 Variation with Breast and Nipple Pain in Breastfeeding Women. Lucas R et al. 2021 Pain management nursing
33324248 Genetic Determinants of Gating Functions: Do We Get Closer to Understanding Schizophrenia Etiopathogenesis? Rovný R et al. 2020 Frontiers in psychiatry
33360592 Fluoride exposure, dopamine relative gene polymorphism and intelligence: A cross-sectional study in China. Zhao L et al. 2021 Ecotoxicology and environmental safety
33450700 The COMT gene rs4680 polymorphism moderates the relationship between adult ADHD symptoms and executive dysfunction. Liu J et al. 2021 Asian journal of psychiatry
33451866 Influence of ADRB1, ADRB2, and COMT Genetic Polymorphisms on Postoperative Outcomes of Patients Undergoing Cardiac Valve Surgery. Dai S et al. 2021 Clinical therapeutics
33453563 Association between COMT methylation and response to treatment in children with ADHD. Fageera W et al. 2021 Journal of psychiatric research
33561612 Genetic variants in levodopa-induced dyskinesia (LID): A systematic review and meta-analysis. Falla M et al. 2021 Parkinsonism & related disorders
33588721 Risk Genes in Schizophrenia and Their Importance in Choosing the Appropriate Antipsychotic Treatment. Werner FM et al. 2021 Current pharmaceutical design
33632172 Discovery of breast cancer risk genes and establishment of a prediction model based on estrogen metabolism regulation. Zhao F et al. 2021 BMC cancer
33666309 No links between genetic variation and developing theory of mind: A preregistered replication attempt of candidate gene studies. Opitz T et al. 2021 Developmental science
33716034 Genetic Predictors of Response to Acupuncture or Cognitive Behavioral Therapy for Insomnia in Cancer Survivors: An Exploratory Analysis. Genovese TJ et al. 2021 Journal of pain and symptom management

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

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Select flank length:

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post629+eb05767