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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs4633

Current Build 155

Released April 9, 2021

Organism
Homo sapiens
Position
chr22:19962712 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
C>T
Variation Type
SNV Single Nucleotide Variation
Frequency
T=0.427413 (113132/264690, TOPMED)
T=0.463452 (115901/250082, GnomAD_exome)
T=0.492454 (83865/170300, ALFA) (+ 24 more)
T=0.446973 (62612/140080, GnomAD)
T=0.467967 (56039/119750, ExAC)
T=0.35796 (27988/78188, PAGE_STUDY)
T=0.30585 (5126/16760, 8.3KJPN)
T=0.46009 (5983/13004, GO-ESP)
T=0.3716 (1861/5008, 1000G)
C=0.4513 (2022/4480, Estonian)
C=0.4862 (1874/3854, ALSPAC)
C=0.5000 (1854/3708, TWINSUK)
T=0.5000 (1854/3708, TWINSUK)
T=0.2780 (814/2928, KOREAN)
C=0.4895 (1301/2658, PharmGKB)
T=0.2620 (480/1832, Korea1K)
C=0.481 (480/998, GoNL)
T=0.234 (178/762, PRJEB37584)
T=0.245 (149/609, Vietnamese)
C=0.463 (278/600, NorthernSweden)
T=0.395 (211/534, MGP)
C=0.347 (118/340, SGDP_PRJ)
C=0.453 (134/296, FINRISK)
C=0.463 (100/216, Qatari)
C=0.40 (28/70, Ancient Sardinia)
C=0.33 (14/42, Siberian)
C=0.30 (12/40, GENOME_DK)
Clinical Significance
Reported in ClinVar
Gene : Consequence
COMT : Synonymous Variant
MIR4761 : 2KB Upstream Variant
Publications
110 citations
Genomic View
See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 170300 C=0.507546 T=0.492454
European Sub 142828 C=0.493482 T=0.506518
African Sub 7428 C=0.6672 T=0.3328
African Others Sub 234 C=0.709 T=0.291
African American Sub 7194 C=0.6658 T=0.3342
Asian Sub 554 C=0.740 T=0.260
East Asian Sub 426 C=0.709 T=0.291
Other Asian Sub 128 C=0.844 T=0.156
Latin American 1 Sub 1090 C=0.5817 T=0.4183
Latin American 2 Sub 7110 C=0.5842 T=0.4158
South Asian Sub 174 C=0.511 T=0.489
Other Sub 11116 C=0.51358 T=0.48642


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 C=0.572587 T=0.427413
gnomAD - Exomes Global Study-wide 250082 C=0.536548 T=0.463452
gnomAD - Exomes European Sub 134368 C=0.477070 T=0.522930
gnomAD - Exomes Asian Sub 48954 C=0.61834 T=0.38166
gnomAD - Exomes American Sub 34478 C=0.59467 T=0.40533
gnomAD - Exomes African Sub 16136 C=0.66770 T=0.33230
gnomAD - Exomes Ashkenazi Jewish Sub 10036 C=0.53049 T=0.46951
gnomAD - Exomes Other Sub 6110 C=0.5249 T=0.4751
Allele Frequency Aggregator Total Global 170300 C=0.507546 T=0.492454
Allele Frequency Aggregator European Sub 142828 C=0.493482 T=0.506518
Allele Frequency Aggregator Other Sub 11116 C=0.51358 T=0.48642
Allele Frequency Aggregator African Sub 7428 C=0.6672 T=0.3328
Allele Frequency Aggregator Latin American 2 Sub 7110 C=0.5842 T=0.4158
Allele Frequency Aggregator Latin American 1 Sub 1090 C=0.5817 T=0.4183
Allele Frequency Aggregator Asian Sub 554 C=0.740 T=0.260
Allele Frequency Aggregator South Asian Sub 174 C=0.511 T=0.489
gnomAD - Genomes Global Study-wide 140080 C=0.553027 T=0.446973
gnomAD - Genomes European Sub 75866 C=0.47440 T=0.52560
gnomAD - Genomes African Sub 41968 C=0.66818 T=0.33182
gnomAD - Genomes American Sub 13648 C=0.59152 T=0.40848
gnomAD - Genomes Ashkenazi Jewish Sub 3320 C=0.5452 T=0.4548
gnomAD - Genomes East Asian Sub 3128 C=0.7340 T=0.2660
gnomAD - Genomes Other Sub 2150 C=0.5842 T=0.4158
ExAC Global Study-wide 119750 C=0.532033 T=0.467967
ExAC Europe Sub 72204 C=0.47641 T=0.52359
ExAC Asian Sub 25028 C=0.60820 T=0.39180
ExAC American Sub 11422 C=0.59709 T=0.40291
ExAC African Sub 10206 C=0.66676 T=0.33324
ExAC Other Sub 890 C=0.522 T=0.478
The PAGE Study Global Study-wide 78188 C=0.64204 T=0.35796
The PAGE Study AfricanAmerican Sub 32204 C=0.66616 T=0.33384
The PAGE Study Mexican Sub 10782 C=0.59293 T=0.40707
The PAGE Study Asian Sub 8266 C=0.6953 T=0.3047
The PAGE Study PuertoRican Sub 7886 C=0.5970 T=0.4030
The PAGE Study NativeHawaiian Sub 4502 C=0.7332 T=0.2668
The PAGE Study Cuban Sub 4212 C=0.5883 T=0.4117
The PAGE Study Dominican Sub 3814 C=0.6088 T=0.3912
The PAGE Study CentralAmerican Sub 2444 C=0.5810 T=0.4190
The PAGE Study SouthAmerican Sub 1976 C=0.6022 T=0.3978
The PAGE Study NativeAmerican Sub 1256 C=0.5677 T=0.4323
The PAGE Study SouthAsian Sub 846 C=0.561 T=0.439
8.3KJPN JAPANESE Study-wide 16760 C=0.69415 T=0.30585
GO Exome Sequencing Project Global Study-wide 13004 C=0.53991 T=0.46009
GO Exome Sequencing Project European American Sub 8600 C=0.4771 T=0.5229
GO Exome Sequencing Project African American Sub 4404 C=0.6626 T=0.3374
1000Genomes Global Study-wide 5008 C=0.6284 T=0.3716
1000Genomes African Sub 1322 C=0.7065 T=0.2935
1000Genomes East Asian Sub 1008 C=0.7302 T=0.2698
1000Genomes Europe Sub 1006 C=0.5010 T=0.4990
1000Genomes South Asian Sub 978 C=0.555 T=0.445
1000Genomes American Sub 694 C=0.620 T=0.380
Genetic variation in the Estonian population Estonian Study-wide 4480 C=0.4513 T=0.5487
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 C=0.4862 T=0.5138
UK 10K study - Twins TWIN COHORT Study-wide 3708 C=0.5000 T=0.5000
KOREAN population from KRGDB KOREAN Study-wide 2928 C=0.7220 T=0.2780
PharmGKB Aggregated Global Study-wide 2658 C=0.4895 T=0.5105
PharmGKB Aggregated PA156001462 Sub 2418 C=0.4760 T=0.5240
PharmGKB Aggregated PA137868583 Sub 240 C=0.625 T=0.375
Korean Genome Project KOREAN Study-wide 1832 C=0.7380 T=0.2620
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 C=0.481 T=0.519
CNV burdens in cranial meningiomas Global Study-wide 762 C=0.766 T=0.234
CNV burdens in cranial meningiomas CRM Sub 762 C=0.766 T=0.234
A Vietnamese Genetic Variation Database Global Study-wide 609 C=0.755 T=0.245
Northern Sweden ACPOP Study-wide 600 C=0.463 T=0.537
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 C=0.605 T=0.395
SGDP_PRJ Global Study-wide 340 C=0.347 T=0.653
FINRISK Finnish from FINRISK project Study-wide 296 C=0.453 T=0.547
Qatari Global Study-wide 216 C=0.463 T=0.537
Ancient Sardinia genome-wide 1240k capture data generation and analysis Global Study-wide 70 C=0.40 T=0.60
Siberian Global Study-wide 42 C=0.33 T=0.67
The Danish reference pan genome Danish Study-wide 40 C=0.30 T=0.70
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 22 NC_000022.11:g.19962712C>T
GRCh37.p13 chr 22 NC_000022.10:g.19950235C>T
COMT RefSeqGene (LRG_1010) NG_011526.1:g.25973C>T
Gene: COMT, catechol-O-methyltransferase (plus strand)
Molecule type Change Amino acid[Codon] SO Term
COMT transcript variant 3 NM_001135162.2:c.186C>T H [CAC] > H [CAT] Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT NP_001128634.1:p.His62= H (His) > H (His) Synonymous Variant
COMT transcript variant 2 NM_001135161.2:c.186C>T H [CAC] > H [CAT] Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT NP_001128633.1:p.His62= H (His) > H (His) Synonymous Variant
COMT transcript variant 5 NM_001362828.2:c.186C>T H [CAC] > H [CAT] Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT NP_001349757.1:p.His62= H (His) > H (His) Synonymous Variant
COMT transcript variant 4 NM_007310.3:c.36C>T H [CAC] > H [CAT] Coding Sequence Variant
catechol O-methyltransferase isoform S-COMT NP_009294.1:p.His12= H (His) > H (His) Synonymous Variant
COMT transcript variant 1 NM_000754.4:c.186C>T H [CAC] > H [CAT] Coding Sequence Variant
catechol O-methyltransferase isoform MB-COMT NP_000745.1:p.His62= H (His) > H (His) Synonymous Variant
Gene: MIR4761, microRNA 4761 (plus strand) : 2KB Upstream Variant
Molecule type Change Amino acid[Codon] SO Term
MIR4761 transcript NR_039918.1:n. N/A Upstream Transcript Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: T (allele ID: 257574 )
ClinVar Accession Disease Names Clinical Significance
RCV000249561.1 not specified Benign
RCV001028888.1 Tramadol response Drug-Response
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement C= T
GRCh38.p13 chr 22 NC_000022.11:g.19962712= NC_000022.11:g.19962712C>T
GRCh37.p13 chr 22 NC_000022.10:g.19950235= NC_000022.10:g.19950235C>T
COMT RefSeqGene (LRG_1010) NG_011526.1:g.25973= NG_011526.1:g.25973C>T
COMT transcript variant 1 NM_000754.4:c.186= NM_000754.4:c.186C>T
COMT transcript variant 1 NM_000754.3:c.186= NM_000754.3:c.186C>T
COMT transcript variant 4 NM_007310.3:c.36= NM_007310.3:c.36C>T
COMT transcript variant 4 NM_007310.2:c.36= NM_007310.2:c.36C>T
COMT transcript variant 5 NM_001362828.2:c.186= NM_001362828.2:c.186C>T
COMT transcript variant 5 NM_001362828.1:c.186= NM_001362828.1:c.186C>T
COMT transcript variant 2 NM_001135161.2:c.186= NM_001135161.2:c.186C>T
COMT transcript variant 2 NM_001135161.1:c.186= NM_001135161.1:c.186C>T
COMT transcript variant 3 NM_001135162.2:c.186= NM_001135162.2:c.186C>T
COMT transcript variant 3 NM_001135162.1:c.186= NM_001135162.1:c.186C>T
catechol O-methyltransferase isoform MB-COMT NP_000745.1:p.His62= NP_000745.1:p.His62=
catechol O-methyltransferase isoform S-COMT NP_009294.1:p.His12= NP_009294.1:p.His12=
catechol O-methyltransferase isoform MB-COMT NP_001349757.1:p.His62= NP_001349757.1:p.His62=
catechol O-methyltransferase isoform MB-COMT NP_001128633.1:p.His62= NP_001128633.1:p.His62=
catechol O-methyltransferase isoform MB-COMT NP_001128634.1:p.His62= NP_001128634.1:p.His62=
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

144 SubSNP, 26 Frequency, 2 ClinVar submissions
No Submitter Submission ID Date (Build)
1 WIAF-CSNP ss7894 Sep 19, 2000 (52)
2 CGAP-GAI ss9560 Sep 19, 2000 (52)
3 TSC-CSHL ss106161 Oct 05, 2000 (92)
4 KWOK ss232567 Jul 12, 2000 (87)
5 SC ss459083 Jul 12, 2000 (87)
6 SC_JCM ss537390 Jul 16, 2000 (87)
7 KWOK ss1058119 Oct 04, 2000 (87)
8 KWOK ss1750405 Oct 18, 2000 (87)
9 AFFX ss2982267 Jun 15, 2001 (100)
10 YUSUKE ss3194614 Aug 15, 2001 (98)
11 LEE ss4401653 May 29, 2002 (106)
12 LEE ss4437838 May 29, 2002 (106)
13 RIKENSNPRC ss6311514 Feb 20, 2003 (111)
14 SNP500CANCER ss6903717 Mar 31, 2003 (113)
15 HG_BONN_CNS_SNPS ss12586772 Aug 26, 2003 (117)
16 EGP_SNPS ss12673754 Dec 05, 2003 (119)
17 SC_SNP ss13346914 Dec 05, 2003 (119)
18 SSAHASNP ss21856914 Apr 05, 2004 (121)
19 IMCJ-GDT ss22886944 Apr 05, 2004 (121)
20 PERLEGEN ss24702129 Sep 20, 2004 (123)
21 ABI ss44321755 Mar 11, 2006 (126)
22 APPLERA_GI ss48413545 Mar 11, 2006 (126)
23 KRIBB_YJKIM ss65824276 Nov 30, 2006 (127)
24 AFFY ss66251088 Nov 30, 2006 (127)
25 PHARMGKB_PPII ss69367701 May 17, 2007 (127)
26 SI_EXO ss71645653 May 17, 2007 (127)
27 ILLUMINA ss75254687 Dec 06, 2007 (129)
28 AFFY ss76396340 Dec 06, 2007 (129)
29 KRIBB_YJKIM ss81404112 Dec 15, 2007 (130)
30 BCMHGSC_JDW ss91877544 Mar 24, 2008 (129)
31 HUMANGENOME_JCVI ss96092644 Feb 06, 2009 (130)
32 SHGC ss99307584 Feb 06, 2009 (130)
33 PHARMGKB_PPII ss105109905 Feb 06, 2009 (130)
34 1000GENOMES ss112551457 Jan 25, 2009 (130)
35 ENSEMBL ss138335197 Dec 01, 2009 (131)
36 ENSEMBL ss142884115 Dec 01, 2009 (131)
37 GMI ss157034576 Dec 01, 2009 (131)
38 SEATTLESEQ ss159743875 Dec 01, 2009 (131)
39 ILLUMINA ss160692506 Dec 01, 2009 (131)
40 COMPLETE_GENOMICS ss171832761 Jul 04, 2010 (132)
41 AFFY ss173468326 Jul 04, 2010 (132)
42 ILLUMINA ss173764533 Jul 04, 2010 (132)
43 BUSHMAN ss204050442 Jul 04, 2010 (132)
44 BCM-HGSC-SUB ss208820822 Jul 04, 2010 (132)
45 1000GENOMES ss228618138 Jul 14, 2010 (132)
46 1000GENOMES ss238022299 Jul 15, 2010 (132)
47 1000GENOMES ss244151657 Jul 15, 2010 (132)
48 ILLUMINA ss244300287 Jul 04, 2010 (132)
49 GMI ss283587216 May 04, 2012 (137)
50 GMI ss287550244 Apr 25, 2013 (138)
51 PJP ss292736316 May 09, 2011 (134)
52 NHLBI-ESP ss342536605 May 09, 2011 (134)
53 ILLUMINA ss410934497 Sep 17, 2011 (135)
54 ILLUMINA ss480984712 May 04, 2012 (137)
55 ILLUMINA ss481005258 May 04, 2012 (137)
56 ILLUMINA ss481984179 Sep 08, 2015 (146)
57 ILLUMINA ss485287283 May 04, 2012 (137)
58 1000GENOMES ss491188308 May 04, 2012 (137)
59 CLINSEQ_SNP ss491819525 May 04, 2012 (137)
60 TISHKOFF ss566560782 Apr 25, 2013 (138)
61 SSMP ss662483740 Apr 25, 2013 (138)
62 ILLUMINA ss783089537 Sep 08, 2015 (146)
63 ILLUMINA ss832347994 Sep 08, 2015 (146)
64 JMKIDD_LAB ss974512058 Aug 21, 2014 (142)
65 EVA-GONL ss995222787 Aug 21, 2014 (142)
66 JMKIDD_LAB ss1067603851 Aug 21, 2014 (142)
67 JMKIDD_LAB ss1082570458 Aug 21, 2014 (142)
68 1000GENOMES ss1366683075 Aug 21, 2014 (142)
69 DDI ss1429219781 Apr 01, 2015 (144)
70 EVA_GENOME_DK ss1579704262 Apr 01, 2015 (144)
71 EVA_FINRISK ss1584126408 Apr 01, 2015 (144)
72 EVA_UK10K_ALSPAC ss1639753927 Apr 01, 2015 (144)
73 EVA_UK10K_TWINSUK ss1682747960 Apr 01, 2015 (144)
74 EVA_EXAC ss1694228849 Apr 01, 2015 (144)
75 EVA_DECODE ss1699291890 Apr 01, 2015 (144)
76 EVA_MGP ss1711560470 Apr 01, 2015 (144)
77 EVA_SVP ss1713731243 Apr 01, 2015 (144)
78 ILLUMINA ss1752413965 Sep 08, 2015 (146)
79 WEILL_CORNELL_DGM ss1938784386 Feb 12, 2016 (147)
80 ILLUMINA ss1959965698 Feb 12, 2016 (147)
81 GENOMED ss1969246875 Jul 19, 2016 (147)
82 JJLAB ss2030165207 Sep 14, 2016 (149)
83 USC_VALOUEV ss2158775164 Dec 20, 2016 (150)
84 HUMAN_LONGEVITY ss2246456938 Dec 20, 2016 (150)
85 TOPMED ss2413283818 Dec 20, 2016 (150)
86 SYSTEMSBIOZJU ss2629580753 Nov 08, 2017 (151)
87 ILLUMINA ss2633862763 Nov 08, 2017 (151)
88 GRF ss2704518119 Nov 08, 2017 (151)
89 GNOMAD ss2744959884 Nov 08, 2017 (151)
90 GNOMAD ss2750498409 Nov 08, 2017 (151)
91 GNOMAD ss2972986201 Nov 08, 2017 (151)
92 AFFY ss2985850700 Nov 08, 2017 (151)
93 SWEGEN ss3019086357 Nov 08, 2017 (151)
94 ILLUMINA ss3022171885 Nov 08, 2017 (151)
95 EVA_SAMSUNG_MC ss3023073333 Nov 08, 2017 (151)
96 BIOINF_KMB_FNS_UNIBA ss3028920318 Nov 08, 2017 (151)
97 CSHL ss3352776488 Nov 08, 2017 (151)
98 TOPMED ss3374060861 Nov 08, 2017 (151)
99 ILLUMINA ss3633984248 Oct 12, 2018 (152)
100 ILLUMINA ss3634860938 Oct 12, 2018 (152)
101 ILLUMINA ss3635668886 Oct 12, 2018 (152)
102 ILLUMINA ss3636556575 Oct 12, 2018 (152)
103 ILLUMINA ss3637421078 Oct 12, 2018 (152)
104 ILLUMINA ss3638374436 Oct 12, 2018 (152)
105 ILLUMINA ss3640568239 Oct 12, 2018 (152)
106 ILLUMINA ss3641136367 Oct 12, 2018 (152)
107 ILLUMINA ss3641432752 Oct 12, 2018 (152)
108 ILLUMINA ss3643334844 Oct 12, 2018 (152)
109 OMUKHERJEE_ADBS ss3646561240 Oct 12, 2018 (152)
110 URBANLAB ss3651151883 Oct 12, 2018 (152)
111 ILLUMINA ss3652633437 Oct 12, 2018 (152)
112 EGCUT_WGS ss3685618858 Jul 13, 2019 (153)
113 EVA_DECODE ss3707954942 Jul 13, 2019 (153)
114 ACPOP ss3743823275 Jul 13, 2019 (153)
115 ILLUMINA ss3745160769 Jul 13, 2019 (153)
116 EVA ss3759230907 Jul 13, 2019 (153)
117 PAGE_CC ss3772082264 Jul 13, 2019 (153)
118 ILLUMINA ss3772656752 Jul 13, 2019 (153)
119 PACBIO ss3788793359 Jul 13, 2019 (153)
120 PACBIO ss3793664451 Jul 13, 2019 (153)
121 PACBIO ss3798550776 Jul 13, 2019 (153)
122 KHV_HUMAN_GENOMES ss3822398799 Jul 13, 2019 (153)
123 EVA ss3825423892 Apr 27, 2020 (154)
124 EVA ss3825534087 Apr 27, 2020 (154)
125 EVA ss3825548347 Apr 27, 2020 (154)
126 EVA ss3825965505 Apr 27, 2020 (154)
127 EVA ss3835927798 Apr 27, 2020 (154)
128 EVA ss3841592399 Apr 27, 2020 (154)
129 EVA ss3847107059 Apr 27, 2020 (154)
130 SGDP_PRJ ss3890256781 Apr 27, 2020 (154)
131 KRGDB ss3940640369 Apr 27, 2020 (154)
132 KOGIC ss3983389633 Apr 27, 2020 (154)
133 FSA-LAB ss3984229790 Apr 26, 2021 (155)
134 EVA ss3984758323 Apr 26, 2021 (155)
135 EVA ss3985910176 Apr 26, 2021 (155)
136 EVA ss3986086720 Apr 26, 2021 (155)
137 EVA ss3986853407 Apr 26, 2021 (155)
138 EVA ss4017873649 Apr 26, 2021 (155)
139 EVA ss4381335188 Apr 26, 2021 (155)
140 TOPMED ss5105107649 Apr 26, 2021 (155)
141 TOMMO_GENOMICS ss5232040510 Apr 26, 2021 (155)
142 EVA ss5236988672 Apr 26, 2021 (155)
143 EVA ss5237254839 Apr 26, 2021 (155)
144 EVA ss5237615141 Apr 26, 2021 (155)
145 1000Genomes NC_000022.10 - 19950235 Oct 12, 2018 (152)
146 The Avon Longitudinal Study of Parents and Children NC_000022.10 - 19950235 Oct 12, 2018 (152)
147 Genetic variation in the Estonian population NC_000022.10 - 19950235 Oct 12, 2018 (152)
148 ExAC NC_000022.10 - 19950235 Oct 12, 2018 (152)
149 FINRISK NC_000022.10 - 19950235 Apr 27, 2020 (154)
150 The Danish reference pan genome NC_000022.10 - 19950235 Apr 27, 2020 (154)
151 gnomAD - Genomes NC_000022.11 - 19962712 Apr 26, 2021 (155)
152 gnomAD - Exomes NC_000022.10 - 19950235 Jul 13, 2019 (153)
153 GO Exome Sequencing Project NC_000022.10 - 19950235 Oct 12, 2018 (152)
154 Genome of the Netherlands Release 5 NC_000022.10 - 19950235 Apr 27, 2020 (154)
155 KOREAN population from KRGDB NC_000022.10 - 19950235 Apr 27, 2020 (154)
156 Korean Genome Project NC_000022.11 - 19962712 Apr 27, 2020 (154)
157 Medical Genome Project healthy controls from Spanish population NC_000022.10 - 19950235 Apr 27, 2020 (154)
158 Northern Sweden NC_000022.10 - 19950235 Jul 13, 2019 (153)
159 The PAGE Study NC_000022.11 - 19962712 Jul 13, 2019 (153)
160 Ancient Sardinia genome-wide 1240k capture data generation and analysis NC_000022.10 - 19950235 Apr 26, 2021 (155)
161 CNV burdens in cranial meningiomas NC_000022.10 - 19950235 Apr 26, 2021 (155)
162 PharmGKB Aggregated NC_000022.11 - 19962712 Apr 27, 2020 (154)
163 Qatari NC_000022.10 - 19950235 Apr 27, 2020 (154)
164 SGDP_PRJ NC_000022.10 - 19950235 Apr 27, 2020 (154)
165 Siberian NC_000022.10 - 19950235 Apr 27, 2020 (154)
166 8.3KJPN NC_000022.10 - 19950235 Apr 26, 2021 (155)
167 TopMed NC_000022.11 - 19962712 Apr 26, 2021 (155)
168 UK 10K study - Twins NC_000022.10 - 19950235 Oct 12, 2018 (152)
169 A Vietnamese Genetic Variation Database NC_000022.10 - 19950235 Jul 13, 2019 (153)
170 ALFA NC_000022.11 - 19962712 Apr 26, 2021 (155)
171 ClinVar RCV000249561.1 Oct 12, 2018 (152)
172 ClinVar RCV001028888.1 Apr 27, 2020 (154)
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History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs4906 Oct 23, 2000 (87)
rs165735 Sep 19, 2000 (85)
rs752985 Jan 18, 2001 (92)
rs2070105 Sep 28, 2001 (100)
rs3171582 Jul 03, 2002 (106)
rs17349382 Mar 11, 2006 (126)
rs17818166 Oct 07, 2004 (123)
rs58430367 Feb 27, 2009 (130)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss66251088, ss76396340, ss91877544, ss112551457, ss171832761, ss173468326, ss204050442, ss208820822, ss283587216, ss287550244, ss292736316, ss480984712, ss491819525, ss1699291890, ss1713731243, ss3643334844 NC_000022.9:18330234:C:T NC_000022.11:19962711:C:T (self)
80217506, 44381996, 31357106, 5801063, 122869, 5869201, 14289369, 1880750, 19773896, 47817763, 676230, 17108140, 1136103, 307904, 20826308, 42273761, 11291518, 90009817, 44381996, 9792530, ss228618138, ss238022299, ss244151657, ss342536605, ss481005258, ss481984179, ss485287283, ss491188308, ss566560782, ss662483740, ss783089537, ss832347994, ss974512058, ss995222787, ss1067603851, ss1082570458, ss1366683075, ss1429219781, ss1579704262, ss1584126408, ss1639753927, ss1682747960, ss1694228849, ss1711560470, ss1752413965, ss1938784386, ss1959965698, ss1969246875, ss2030165207, ss2158775164, ss2413283818, ss2629580753, ss2633862763, ss2704518119, ss2744959884, ss2750498409, ss2972986201, ss2985850700, ss3019086357, ss3022171885, ss3023073333, ss3352776488, ss3633984248, ss3634860938, ss3635668886, ss3636556575, ss3637421078, ss3638374436, ss3640568239, ss3641136367, ss3641432752, ss3646561240, ss3652633437, ss3685618858, ss3743823275, ss3745160769, ss3759230907, ss3772656752, ss3788793359, ss3793664451, ss3798550776, ss3825423892, ss3825534087, ss3825548347, ss3825965505, ss3835927798, ss3841592399, ss3890256781, ss3940640369, ss3984229790, ss3984758323, ss3985910176, ss3986086720, ss3986853407, ss4017873649, ss5232040510, ss5237615141 NC_000022.10:19950234:C:T NC_000022.11:19962711:C:T (self)
RCV000249561.1, RCV001028888.1, 566543606, 39767634, 1303733, 7566, 237443209, 380216596, 929729463, ss2246456938, ss3028920318, ss3374060861, ss3651151883, ss3707954942, ss3772082264, ss3822398799, ss3847107059, ss3983389633, ss4381335188, ss5105107649, ss5236988672, ss5237254839 NC_000022.11:19962711:C:T NC_000022.11:19962711:C:T (self)
ss7894, ss9560, ss106161, ss232567, ss459083, ss537390, ss1058119, ss1750405, ss2982267, ss3194614, ss4401653, ss4437838, ss6311514, ss6903717, ss12586772, ss12673754, ss13346914, ss21856914, ss22886944, ss24702129, ss44321755, ss48413545, ss65824276, ss69367701, ss71645653, ss75254687, ss81404112, ss96092644, ss99307584, ss105109905, ss138335197, ss142884115, ss157034576, ss159743875, ss160692506, ss173764533, ss244300287, ss410934497 NT_011519.10:3102384:C:T NC_000022.11:19962711:C:T (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

110 citations for rs4633
PMID Title Author Year Journal
12802784 A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Bray NJ et al. 2003 American journal of human genetics
15505638 Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia. Handoko HY et al. 2005 Molecular psychiatry
16380905 Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Fallin MD et al. 2005 American journal of human genetics
16848906 Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans. Kim H et al. 2006 Molecular pain
16882734 Genetic predictors for acute experimental cold and heat pain sensitivity in humans. Kim H et al. 2006 Journal of medical genetics
17363961 Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment. Molero P et al. 2007 The pharmacogenomics journal
17961261 Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. Vargas-Alarcón G et al. 2007 Arthritis research & therapy
18064318 Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk. Gellekink H et al. 2007 Thrombosis and haemostasis
18324659 COMT polymorphisms affecting protein expression are risk factors for endometrial cancer. Hirata H et al. 2008 Molecular carcinogenesis
18389087 Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing. Kan T et al. 2007 Bioinformatics and biology insights
18574484 The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase. Mukherjee N et al. 2010 Molecular psychiatry
18663369 Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Strug LJ et al. 2010 Molecular psychiatry
18698231 Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. Johnson AD et al. 2008 Pharmacogenetics and genomics
18698234 The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications. Bialecka M et al. 2008 Pharmacogenetics and genomics
18802928 Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults. Halleland H et al. 2009 American journal of medical genetics. Part B, Neuropsychiatric genetics
19015200 Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer. Freedman ND et al. 2009 Carcinogenesis
19094200 Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. Rakvåg TT et al. 2008 Molecular pain
19159868 Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia. Wang Y et al. 2009 Biological psychiatry
19168589 Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China. Park SK et al. 2009 Carcinogenesis
19290789 Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment. Gupta M et al. 2009 Pharmacogenomics
19365560 Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs. Nackley AG et al. 2009 PloS one
19693267 Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. Roe BE et al. 2009 PloS one
19772600 A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data. Huang LC et al. 2009 Journal of translational medicine
19852950 The association of catechol-O-methyltransferase genotype with the phenotype of women with eating disorders. Mikołajczyk E et al. 2010 Brain research
20083391 A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry. Strohmaier J et al. 2010 Schizophrenia research
20483479 Analysis of association between the catechol-O-methyltransferase (COMT) gene and negative symptoms in chronic schizophrenia. Wang Y et al. 2010 Psychiatry research
20531207 The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study. Kocabas NA et al. 2010 International clinical psychopharmacology
20551675 Localizing putative markers in genetic association studies by incorporating linkage disequilibrium into bayesian hierarchical models. Fridley BL et al. 2010 Human heredity
20570835 No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain. Nicholl BI et al. 2010 Annals of the rheumatic diseases
20627703 The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder. Fijal B et al. 2010 The journal of pain
20667552 Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study. Calati R et al. 2011 Journal of psychiatric research
20863768 Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease. Dai F et al. 2010 The spine journal
20877297 Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response. Ji Y et al. 2012 The pharmacogenomics journal
21107304 Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. Jacobson PA et al. 2011 Transplantation
21289622 Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy. Sadee W et al. 2011 Clinical pharmacology and therapeutics
21300128 COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa. Yilmaz Z et al. 2011 Progress in neuro-psychopharmacology & biological psychiatry
21304959 Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia. Hill LD et al. 2011 PloS one
21423693 Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures. Doehring A et al. 2011 PloS one
21462137 [An association study of COMT gene polymorphisms with schizophrenia]. KONG FZ et al. 2011 Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
21527290 Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. Nemoda Z et al. 2011 Neuroscience and biobehavioral reviews
21570824 Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids. Laugsand EA et al. 2011 European journal of cancer (Oxford, England
21680027 Influence and interaction of genetic polymorphisms in catecholamine neurotransmitter systems and early life stress on antidepressant drug response. Xu Z et al. 2011 Journal of affective disorders
21708280 Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis. Srivastava K et al. 2011 Mutation research
21905019 Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia. Smith SB et al. 2012 Arthritis and rheumatism
21940152 The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder--a European multicenter study. Schosser A et al. 2012 European neuropsychopharmacology
22105624 The genetics of attention deficit/hyperactivity disorder in adults, a review. Franke B et al. 2012 Molecular psychiatry
22178088 Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome. Hill LD et al. 2012 Molecular and cellular endocrinology
22253202 Catechol-O-methyltransferase polymorphisms do not play a significant role in pain perception in male Chinese Han population. Xiang X et al. 2012 Physiological genomics
22451510 Catechol-o-methyltransferase gene and executive function in children with ADHD. Choudhry Z et al. 2014 Journal of attention disorders
22528689 Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene. Martínez-Jauand M et al. 2013 European journal of pain (London, England)
22701660 Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guérin. Wei H et al. 2012 PloS one
22890010 Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease. Białecka M et al. 2012 Pharmacogenetics and genomics
22939719 Oxytocin and catechol-O-methyltransferase receptor genotype predict the length of the first stage of labor. Terkawi AS et al. 2012 American journal of obstetrics and gynecology
23209597 Investigating the genetic basis of theory of mind (ToM): the role of catechol-O-methyltransferase (COMT) gene polymorphisms. Xia H et al. 2012 PloS one
23766564 Pharmacogenetics of chronic pain and its treatment. Světlík S et al. 2013 Mediators of inflammation
23922910 A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk. Kelly LE et al. 2013 PloS one
23963787 Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision. Bortsov AV et al. 2014 Neuromolecular medicine
24178190 Influence of variation in the catechol-O-methyltransferase gene on the clinical outcome after lumbar spine surgery for one-level symptomatic disc disease: a report on 176 cases. Rut M et al. 2014 Acta neurochirurgica
24234932 Association Between Catechol-O-Methyltransferase (COMT) Gene Polymorphisms, Parkinson's Disease, and Levodopa Efficacy. Yin B et al. 2013 Molecular diagnosis & therapy
24448899 Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype. Zhang Y et al. 2014 Psychopharmacology
24755993 Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences? Bakker JM et al. 2014 Translational psychiatry
24782743 Association of COMT and COMT-DRD2 interaction with creative potential. Zhang S et al. 2014 Frontiers in human neuroscience
24881125 From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment. Fabbri C et al. 2014 Canadian journal of psychiatry. Revue canadienne de psychiatrie
24904231 A novel catechol-O-methyltransferase variant associated with human disc degeneration. Gruber HE et al. 2014 International journal of medical sciences
25040948 The design and methods of genetic studies on acute and chronic postoperative pain in patients after total knee replacement. Belfer I et al. 2014 Pain medicine (Malden, Mass.)
25218601 Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain. Smith SB et al. 2014 Pain
25324626 Research in China on the molecular genetics of schizophrenia. Cui D et al. 2012 Shanghai archives of psychiatry
25532715 COMT gene haplotypes are closely associated with postoperative fentanyl dose in patients. Zhang F et al. 2015 Anesthesia and analgesia
25599448 Association of functional variations in COMT and GCH1 genes with postherniotomy pain and related impairment. Belfer I et al. 2015 Pain
25741868 Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Richards S et al. 2015 Genetics in medicine
25772090 Catechol-O-methyltransferase (COMT) gene polymorphisms are associated with baseline disability but not long-term treatment outcome in patients with chronic low back pain. Omair A et al. 2015 European spine journal
25963335 Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy. Tan EC et al. 2016 The pharmacogenomics journal
26483654 Linking unfounded beliefs to genetic dopamine availability. Schmack K et al. 2015 Frontiers in human neuroscience
26724569 Catechol-O-methyltransferase gene variants may associate with negative symptom response and plasma concentrations of prolactin in schizophrenia after amisulpride treatment. Chen CY et al. 2016 Psychoneuroendocrinology
26808641 Dopamine receptor D2 and catechol-O-methyltransferase gene polymorphisms associated with anorexia nervosa in Chinese Han population: DRD2 and COMT gene polymorphisms were associated with AN. Peng S et al. 2016 Neuroscience letters
26849490 Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study. Park DJ et al. 2016 European journal of pain (London, England)
26988620 No associations between five polymorphisms in COMT gene and migraine. Takigawa H et al. 2017 Acta neurologica Scandinavica
27028297 A Complex Systems Approach to Causal Discovery in Psychiatry. Saxe GN et al. 2016 PloS one
27282867 Catechol-O-methyltransferase association with hemoglobin A1c. Hall KT et al. 2016 Metabolism
27636225 An Expert Review of Pharmacogenomics of Sickle Cell Disease Therapeutics: Not Yet Ready for Global Precision Medicine. Mnika K et al. 2016 Omics
27903758 OPRM1 and COMT Gene-Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma. Khalil H et al. 2017 Biological research for nursing
27917384 Genetic Alterations in Intervertebral Disc Disease. Martirosyan NL et al. 2016 Frontiers in surgery
28451382 Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson's disease. Xiao Q et al. 2017 Translational neurodegeneration
28652652 Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update. Sharma A et al. 2017 World journal of gastroenterology
28740224 Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson's disease. Lin CH et al. 2017 Scientific reports
28822116 Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review. Misiak B et al. 2018 Molecular neurobiology
28927418 A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson's disease. Guin D et al. 2017 BMC medical genomics
29195501 COMT genotype and non-recovery after a whiplash injury in a Northern European population. Rydman E et al. 2017 BMC musculoskeletal disorders
29330410 The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders. Bernegger A et al. 2018 Scientific reports
29331705 Catechol O-methyltransferase (COMT) functional haplotype is associated with recurrence of affective symptoms: A prospective birth cohort study. Koike S et al. 2018 Journal of affective disorders
29439855 Catechol-O-methyltransferase (COMT) genetic variants are associated with cognitive decline in patients with Parkinson's disease. Lin CH et al. 2018 Parkinsonism & related disorders
29559808 Association of genetic variation in <i>COMT</i> gene with pain related to sickle cell disease in patients from the walk-PHaSST study. Zhang Y et al. 2018 Journal of pain research
29692704 Left Parietal Functional Connectivity Mediates the Association Between <i>COMT</i> rs4633 and Verbal Intelligence in Healthy Adults. Xu Q et al. 2018 Frontiers in neuroscience
29760667 A <i>DRD2/ANNK1</i>-<i>COMT</i> Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese. Zhang K et al. 2018 Frontiers in psychiatry
29912452 Genetic Predictors of Response to Acupuncture for Aromatase Inhibitor-Associated Arthralgia Among Breast Cancer Survivors. Genovese TJ et al. 2019 Pain medicine (Malden, Mass.)
30158547 A common polymorphism of COMT was associated with symptomatic lumbar disc herniation based on a large sample with Chinese Han ancestry. Liu H et al. 2018 Scientific reports
30453067 Association of genetic polymorphisms with age at menarche in Russian women. Ponomarenko I et al. 2019 Gene
30597299 A gender-specific COMT haplotype contributes to risk modulation rather than disease severity of major depressive disorder in a Chinese population. Chao JK et al. 2019 Journal of affective disorders
30822160 Association of COMT gene variability with pain intensity in patients after total hip replacement. Machoy-Mokrzyńska A et al. 2019 Scandinavian journal of clinical and laboratory investigation
30886988 Association of Catechol-<i>O</i>-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients. Lee C et al. 2018 BMC rheumatology
30904518 Associations Between Catecholaminergic and Serotonergic Genes and Persistent Arm Pain Severity Following Breast Cancer Surgery. Knisely MR et al. 2019 The journal of pain
31129315 Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain. Chidambaran V et al. 2020 The journal of pain
31552390 Placebo effects and the molecular biological components involved. Cai L et al. 2019 General psychiatry
31806881 OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study. Ho KWD et al. 2020 The pharmacogenomics journal
32024434 COMT gene variants and β-endorphin levels contribute to ethnic differences in experimental pain sensitivity. Xu F et al. 2020 Molecular pain
32034175 COMT-Polymorphisms Modulated Functional Profile of the Fusiform Face Area Contributes to Face-Specific Recognition Ability. Wu C et al. 2020 Scientific reports
32533012 Genetic variations in catechol-O-methyltransferase gene are associated with levodopa response variability in Chinese patients with Parkinson's disease. Zhao C et al. 2020 Scientific reports
32618128 Interaction between catechol-O-methyltransferase polymorphism and childhood trauma in suicidal ideation of patients with post-traumatic stress disorder. Kwon A et al. 2020 Brain and behavior
33303340 OXTR rs53576 Variation with Breast and Nipple Pain in Breastfeeding Women. Lucas R et al. 2021 Pain management nursing
33453563 Association between COMT methylation and response to treatment in children with ADHD. Fageera W et al. 2021 Journal of psychiatric research
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The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

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Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
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Software version is: 2.0.1.post676+237644a