Name: rs429358
Published: April 9, 2021
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs429358

Current Build 155

Released April 9, 2021

Organism: Homo sapiens
Position: chr19:44908684 (GRCh38.p13) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: T>C
Variation Type: SNV Single Nucleotide Variation
Frequency: C=0.155314 (41110/264690, TOPMED)
C=0.138498 (23502/169692, GnomAD_exome)
C=0.160595 (22490/140042, GnomAD) (+ 17 more)
C=0.074418 (7517/101010, ALFA)
C=0.00000 (0/78676, PAGE_STUDY)
C=0.18433 (5332/28926, ExAC)
C=0.10020 (1679/16756, 3.5KJPNv2)
C=0.1506 (754/5008, 1000G)
C=0.1246 (558/4480, Estonian)
C=0.1539 (593/3854, ALSPAC)
C=0.1397 (518/3708, TWINSUK)
C=0.0917 (268/2922, KOREAN)
C=0.0956 (170/1778, Korea1K)
C=0.148 (89/600, NorthernSweden)
C=0.106 (23/216, Qatari)
C=0.014 (3/208, HapMap)
T=0.468 (74/158, SGDP_PRJ)
C=0.23 (9/40, GENOME_DK)
C=0.17 (2/12, Ancient Sardinia)
T=0.2 (1/4, Siberian)

Clinical Significance: Reported in ClinVar
Gene : Consequence: APOE : Missense Variant
Publications: 416 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	101010	T=0.925582	C=0.074418
European	Sub	81794	T=0.93183	C=0.06817
African	Sub	5848	T=0.8712	C=0.1288
African Others	Sub	198	T=0.859	C=0.141
African American	Sub	5650	T=0.8717	C=0.1283
Asian	Sub	514	T=0.963	C=0.037
East Asian	Sub	422	T=0.974	C=0.026
Other Asian	Sub	92	T=0.91	C=0.09
Latin American 1	Sub	860	T=0.890	C=0.110
Latin American 2	Sub	888	T=0.923	C=0.077
South Asian	Sub	168	T=0.952	C=0.048
Other	Sub	10938	T=0.90876	C=0.09124

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	T=0.844686	C=0.155314
gnomAD - Exomes	Global	Study-wide	169692	T=0.861502	C=0.138498
gnomAD - Exomes	European	Sub	84828	T=0.83859	C=0.16141
gnomAD - Exomes	Asian	Sub	36686	T=0.90389	C=0.09611
gnomAD - Exomes	American	Sub	25874	T=0.89739	C=0.10261
gnomAD - Exomes	African	Sub	9082	T=0.7762	C=0.2238
gnomAD - Exomes	Ashkenazi Jewish	Sub	8558	T=0.8850	C=0.1150
gnomAD - Exomes	Other	Sub	4664	T=0.8688	C=0.1312
gnomAD - Genomes	Global	Study-wide	140042	T=0.839405	C=0.160595
gnomAD - Genomes	European	Sub	75814	T=0.85463	C=0.14537
gnomAD - Genomes	African	Sub	41990	T=0.78635	C=0.21365
gnomAD - Genomes	American	Sub	13658	T=0.88952	C=0.11048
gnomAD - Genomes	Ashkenazi Jewish	Sub	3322	T=0.8802	C=0.1198
gnomAD - Genomes	East Asian	Sub	3108	T=0.9035	C=0.0965
gnomAD - Genomes	Other	Sub	2150	T=0.8647	C=0.1353
Allele Frequency Aggregator	Total	Global	101010	T=0.925582	C=0.074418
Allele Frequency Aggregator	European	Sub	81794	T=0.93183	C=0.06817
Allele Frequency Aggregator	Other	Sub	10938	T=0.90876	C=0.09124
Allele Frequency Aggregator	African	Sub	5848	T=0.8712	C=0.1288
Allele Frequency Aggregator	Latin American 2	Sub	888	T=0.923	C=0.077
Allele Frequency Aggregator	Latin American 1	Sub	860	T=0.890	C=0.110
Allele Frequency Aggregator	Asian	Sub	514	T=0.963	C=0.037
Allele Frequency Aggregator	South Asian	Sub	168	T=0.952	C=0.048
The PAGE Study	Global	Study-wide	78676	T=1.00000	C=0.00000
The PAGE Study	AfricanAmerican	Sub	32502	T=1.00000	C=0.00000
The PAGE Study	Mexican	Sub	10806	T=1.00000	C=0.00000
The PAGE Study	Asian	Sub	8316	T=1.0000	C=0.0000
The PAGE Study	PuertoRican	Sub	7918	T=1.0000	C=0.0000
The PAGE Study	NativeHawaiian	Sub	4532	T=1.0000	C=0.0000
The PAGE Study	Cuban	Sub	4230	T=1.0000	C=0.0000
The PAGE Study	Dominican	Sub	3826	T=1.0000	C=0.0000
The PAGE Study	CentralAmerican	Sub	2450	T=1.0000	C=0.0000
The PAGE Study	SouthAmerican	Sub	1980	T=1.0000	C=0.0000
The PAGE Study	NativeAmerican	Sub	1260	T=1.0000	C=0.0000
The PAGE Study	SouthAsian	Sub	856	T=1.000	C=0.000
ExAC	Global	Study-wide	28926	T=0.81567	C=0.18433
ExAC	Europe	Sub	15272	T=0.78719	C=0.21281
ExAC	Asian	Sub	9820	T=0.8855	C=0.1145
ExAC	African	Sub	2496	T=0.7268	C=0.2732
ExAC	American	Sub	1086	T=0.7855	C=0.2145
ExAC	Other	Sub	252	T=0.829	C=0.171
3.5KJPNv2	JAPANESE	Study-wide	16756	T=0.89980	C=0.10020
1000Genomes	Global	Study-wide	5008	T=0.8494	C=0.1506
1000Genomes	African	Sub	1322	T=0.7322	C=0.2678
1000Genomes	East Asian	Sub	1008	T=0.9137	C=0.0863
1000Genomes	Europe	Sub	1006	T=0.8449	C=0.1551
1000Genomes	South Asian	Sub	978	T=0.913	C=0.087
1000Genomes	American	Sub	694	T=0.896	C=0.104
Genetic variation in the Estonian population	Estonian	Study-wide	4480	T=0.8754	C=0.1246
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	T=0.8461	C=0.1539
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	T=0.8603	C=0.1397
KOREAN population from KRGDB	KOREAN	Study-wide	2922	T=0.9083	C=0.0917
Korean Genome Project	KOREAN	Study-wide	1778	T=0.9044	C=0.0956
Northern Sweden	ACPOP	Study-wide	600	T=0.852	C=0.148
Qatari	Global	Study-wide	216	T=0.894	C=0.106
HapMap	Global	Study-wide	208	T=0.986	C=0.014
HapMap	African	Sub	120	T=0.983	C=0.017
HapMap	Asian	Sub	88	T=0.99	C=0.01
SGDP_PRJ	Global	Study-wide	158	T=0.468	C=0.532
The Danish reference pan genome	Danish	Study-wide	40	T=0.78	C=0.23
Ancient Sardinia genome-wide 1240k capture data generation and analysis	Global	Study-wide	12	T=0.83	C=0.17
Siberian	Global	Study-wide	4	T=0.2	C=0.8

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p13 chr 19	NC_000019.10:g.44908684T>C
GRCh37.p13 chr 19	NC_000019.9:g.45411941T>C
APOE RefSeqGene	NG_007084.2:g.7903T>C

Gene: APOE, apolipoprotein E (plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
APOE transcript variant 2	NM_000041.4:c.388T>C	C [TGC] > R [CGC]	Coding Sequence Variant
apolipoprotein E isoform b precursor	NP_000032.1:p.Cys130Arg	C (Cys) > R (Arg)	Missense Variant
APOE transcript variant 3	NM_001302689.2:c.388T>C	C [TGC] > R [CGC]	Coding Sequence Variant
apolipoprotein E isoform b precursor	NP_001289618.1:p.Cys130Arg	C (Cys) > R (Arg)	Missense Variant
APOE transcript variant 1	NM_001302688.2:c.466T>C	C [TGC] > R [CGC]	Coding Sequence Variant
apolipoprotein E isoform a precursor	NP_001289617.1:p.Cys156Arg	C (Cys) > R (Arg)	Missense Variant
APOE transcript variant 5	NM_001302691.2:c.388T>C	C [TGC] > R [CGC]	Coding Sequence Variant
apolipoprotein E isoform b precursor	NP_001289620.1:p.Cys130Arg	C (Cys) > R (Arg)	Missense Variant
APOE transcript variant 4	NM_001302690.2:c.388T>C	C [TGC] > R [CGC]	Coding Sequence Variant
apolipoprotein E isoform b precursor	NP_001289619.1:p.Cys130Arg	C (Cys) > R (Arg)	Missense Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: T= (allele ID: 682795 )

ClinVar Accession	Disease Names	Clinical Significance
RCV000019447.31	APOE3 ISOFORM	Pathogenic
RCV000856604.2	Alzheimer disease 3, protection against, due to APOE3-Christchurch	Protective

Allele: C (allele ID: 32903 )

ClinVar Accession	Disease Names	Clinical Significance
RCV000019438.29	Familial type 3 hyperlipoproteinemia	Pathogenic
RCV000019448.34	Alzheimer disease 2	Pathogenic
RCV000019455.32	Familial type 3 hyperlipoproteinemia	Pathogenic
RCV000019456.28	APOE4(-)-FREIBURG	Pathogenic
RCV000019458.26	APOE5 VARIANT	Association
RCV000292119.3	not provided	Other,Risk-Factor
RCV000825286.1	not specified	Uncertain-Significance
RCV000826089.1	Primary degenerative dementia of the Alzheimer type, presenile onset	Risk-Factor
RCV000845581.1	Warfarin response	Drug-Response
RCV000991302.1	Alzheimer disease	Likely-Pathogenic
RCV001175124.1	Familial hypercholesterolemia	Likely-Pathogenic
RCV001195807.1	Alzheimer disease, type 4	Pathogenic
RCV001262791.1	Lipoprotein glomerulopathy	Uncertain-Significance

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	T=	C
GRCh38.p13 chr 19	NC_000019.10:g.44908684=	NC_000019.10:g.44908684T>C
GRCh37.p13 chr 19	NC_000019.9:g.45411941=	NC_000019.9:g.45411941T>C
APOE RefSeqGene	NG_007084.2:g.7903=	NG_007084.2:g.7903T>C
APOE transcript variant 2	NM_000041.4:c.388=	NM_000041.4:c.388T>C
APOE transcript variant 2	NM_000041.3:c.388=	NM_000041.3:c.388T>C
APOE transcript	NM_000041.2:c.388=	NM_000041.2:c.388T>C
APOE transcript variant 1	NM_001302688.2:c.466=	NM_001302688.2:c.466T>C
APOE transcript variant 1	NM_001302688.1:c.466=	NM_001302688.1:c.466T>C
APOE transcript variant 4	NM_001302690.2:c.388=	NM_001302690.2:c.388T>C
APOE transcript variant 4	NM_001302690.1:c.388=	NM_001302690.1:c.388T>C
APOE transcript variant 5	NM_001302691.2:c.388=	NM_001302691.2:c.388T>C
APOE transcript variant 5	NM_001302691.1:c.388=	NM_001302691.1:c.388T>C
APOE transcript variant 3	NM_001302689.2:c.388=	NM_001302689.2:c.388T>C
APOE transcript variant 3	NM_001302689.1:c.388=	NM_001302689.1:c.388T>C
apolipoprotein E isoform b precursor	NP_000032.1:p.Cys130=	NP_000032.1:p.Cys130Arg
apolipoprotein E isoform a precursor	NP_001289617.1:p.Cys156=	NP_001289617.1:p.Cys156Arg
apolipoprotein E isoform b precursor	NP_001289619.1:p.Cys130=	NP_001289619.1:p.Cys130Arg
apolipoprotein E isoform b precursor	NP_001289620.1:p.Cys130=	NP_001289620.1:p.Cys130Arg
apolipoprotein E isoform b precursor	NP_001289618.1:p.Cys130=	NP_001289618.1:p.Cys130Arg

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

175 SubSNP, 20 Frequency, 15 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	SC_JCM	ss569295	Jul 16, 2000 (80)
2	SC_JCM	ss803061	Aug 11, 2000 (85)
3	DEBNICK	ss870163	Oct 04, 2000 (86)
4	HGBASE	ss2419938	Nov 14, 2000 (89)
5	CUORCGL	ss12568607	Aug 26, 2003 (117)
6	CGAP-GAI	ss16231123	Feb 27, 2004 (120)
7	SSAHASNP	ss21518782	Apr 05, 2004 (121)
8	SEQUENOM	ss24811489	Sep 20, 2004 (123)
9	ABI	ss44158325	Mar 14, 2006 (126)
10	SI_EXO	ss76884559	Dec 06, 2007 (129)
11	KRIBB_YJKIM	ss80743998	Dec 16, 2007 (130)
12	HUMANGENOME_JCVI	ss96308980	Feb 06, 2009 (130)
13	RSG_UW	ss107936537	Feb 06, 2009 (130)
14	ENSEMBL	ss132769779	Dec 01, 2009 (131)
15	SEATTLESEQ	ss159740185	Dec 01, 2009 (131)
16	ILLUMINA	ss160670648	Dec 01, 2009 (131)
17	COMPLETE_GENOMICS	ss168243995	Jul 04, 2010 (132)
18	PAGE_STUDY	ss181341884	Jul 04, 2010 (132)
19	1000GENOMES	ss228156553	Jul 14, 2010 (132)
20	1000GENOMES	ss237689596	Jul 15, 2010 (132)
21	OMICIA	ss244239676	May 27, 2010 (132)
22	OMIM-CURATED-RECORDS	ss275517967	Dec 03, 2010 (133)
23	ILLUMINA	ss410828263	Sep 17, 2011 (135)
24	PAGE_STUDY	ss469414605	May 04, 2012 (137)
25	ILLUMINA	ss481897219	Sep 08, 2015 (146)
26	ILLUMINA	ss483834108	May 04, 2012 (137)
27	ILLUMINA	ss484318107	May 04, 2012 (137)
28	1000GENOMES	ss491161751	May 04, 2012 (137)
29	EXOME_CHIP	ss491549548	May 04, 2012 (137)
30	ILLUMINA	ss536501696	Sep 08, 2015 (146)
31	NCBI-CURATED-RECORDS	ss537712916	Jan 04, 2013 (137)
32	SSMP	ss661874596	Apr 25, 2013 (138)
33	NHLBI-ESP	ss713519649	Apr 25, 2013 (138)
34	ILLUMINA	ss780608662	Aug 21, 2014 (142)
35	ILLUMINA	ss782605255	Aug 21, 2014 (142)
36	ILLUMINA	ss836101974	Aug 21, 2014 (142)
37	JMKIDD_LAB	ss974506672	Aug 21, 2014 (142)
38	EVA-GONL	ss994339187	Aug 21, 2014 (142)
39	JMKIDD_LAB	ss1067590770	Aug 21, 2014 (142)
40	1000GENOMES	ss1363326184	Aug 21, 2014 (142)
41	EVA_GENOME_DK	ss1578653635	Apr 01, 2015 (144)
42	EVA_UK10K_ALSPAC	ss1638043657	Apr 01, 2015 (144)
43	EVA_UK10K_TWINSUK	ss1681037690	Apr 01, 2015 (144)
44	EVA_EXAC	ss1693665397	Apr 01, 2015 (144)
45	EVA_DECODE	ss1698394130	Apr 01, 2015 (144)
46	WEILL_CORNELL_DGM	ss1937835821	Feb 12, 2016 (147)
47	ILLUMINA	ss1959869660	Feb 12, 2016 (147)
48	ILLUMINA	ss1959869661	Feb 12, 2016 (147)
49	ILLUMINA	ss1959869662	Feb 12, 2016 (147)
50	ILLUMINA	ss1959869663	Feb 12, 2016 (147)
51	ILLUMINA	ss1959869665	Feb 12, 2016 (147)
52	ILLUMINA	ss1959869666	Feb 12, 2016 (147)
53	ILLUMINA	ss1959869667	Feb 12, 2016 (147)
54	ILLUMINA	ss1959869668	Feb 12, 2016 (147)
55	ILLUMINA	ss1959869669	Feb 12, 2016 (147)
56	ILLUMINA	ss1959869670	Feb 12, 2016 (147)
57	ILLUMINA	ss1959869671	Feb 12, 2016 (147)
58	ILLUMINA	ss1959869672	Feb 12, 2016 (147)
59	ILLUMINA	ss1959869673	Feb 12, 2016 (147)
60	ILLUMINA	ss1959869675	Feb 12, 2016 (147)
61	ILLUMINA	ss1959869676	Feb 12, 2016 (147)
62	ILLUMINA	ss1959869677	Feb 12, 2016 (147)
63	ILLUMINA	ss1959869678	Feb 12, 2016 (147)
64	ILLUMINA	ss1959869679	Feb 12, 2016 (147)
65	ILLUMINA	ss1959869680	Feb 12, 2016 (147)
66	JJLAB	ss2029695318	Sep 14, 2016 (149)
67	ILLUMINA	ss2095085222	Dec 20, 2016 (150)
68	USC_VALOUEV	ss2158238082	Dec 20, 2016 (150)
69	HUMAN_LONGEVITY	ss2226012248	Dec 20, 2016 (150)
70	TOPMED	ss2391820667	Dec 20, 2016 (150)
71	ILLUMINA	ss2633544198	Nov 08, 2017 (151)
72	ILLUMINA	ss2633544199	Nov 08, 2017 (151)
73	ILLUMINA	ss2633544200	Nov 08, 2017 (151)
74	GRF	ss2702851377	Nov 08, 2017 (151)
75	GNOMAD	ss2744090515	Nov 08, 2017 (151)
76	GNOMAD	ss2750218818	Nov 08, 2017 (151)
77	GNOMAD	ss2963330113	Nov 08, 2017 (151)
78	AFFY	ss2985144680	Nov 08, 2017 (151)
79	AFFY	ss2985775660	Nov 08, 2017 (151)
80	SWEGEN	ss3017540728	Nov 08, 2017 (151)
81	ILLUMINA	ss3021911568	Nov 08, 2017 (151)
82	ILLUMINA	ss3021911569	Nov 08, 2017 (151)
83	ILLUMINA	ss3021911570	Nov 08, 2017 (151)
84	ILLUMINA	ss3021911571	Nov 08, 2017 (151)
85	ILLUMINA	ss3021911572	Nov 08, 2017 (151)
86	ILLUMINA	ss3021911573	Nov 08, 2017 (151)
87	ILLUMINA	ss3021911574	Nov 08, 2017 (151)
88	ILLUMINA	ss3021911575	Nov 08, 2017 (151)
89	ILLUMINA	ss3021911576	Nov 08, 2017 (151)
90	ILLUMINA	ss3021911577	Nov 08, 2017 (151)
91	ILLUMINA	ss3021911578	Nov 08, 2017 (151)
92	ILLUMINA	ss3021911579	Nov 08, 2017 (151)
93	ILLUMINA	ss3021911580	Nov 08, 2017 (151)
94	ILLUMINA	ss3021911581	Nov 08, 2017 (151)
95	ILLUMINA	ss3021911582	Nov 08, 2017 (151)
96	ILLUMINA	ss3021911583	Nov 08, 2017 (151)
97	ILLUMINA	ss3021911584	Nov 08, 2017 (151)
98	ILLUMINA	ss3021911585	Nov 08, 2017 (151)
99	ILLUMINA	ss3021911586	Nov 08, 2017 (151)
100	ILLUMINA	ss3021911587	Nov 08, 2017 (151)
101	ILLUMINA	ss3021911588	Nov 08, 2017 (151)
102	ILLUMINA	ss3021911589	Nov 08, 2017 (151)
103	ILLUMINA	ss3021911590	Nov 08, 2017 (151)
104	ILLUMINA	ss3021911591	Nov 08, 2017 (151)
105	BIOINF_KMB_FNS_UNIBA	ss3028677779	Nov 08, 2017 (151)
106	TOPMED	ss3294331438	Nov 08, 2017 (151)
107	CSHL	ss3352320693	Nov 08, 2017 (151)
108	ILLUMINA	ss3625742825	Oct 12, 2018 (152)
109	ILLUMINA	ss3625742826	Oct 12, 2018 (152)
110	ILLUMINA	ss3625742827	Oct 12, 2018 (152)
111	ILLUMINA	ss3625742828	Oct 12, 2018 (152)
112	ILLUMINA	ss3625742829	Oct 12, 2018 (152)
113	ILLUMINA	ss3627941617	Oct 12, 2018 (152)
114	ILLUMINA	ss3631515218	Oct 12, 2018 (152)
115	ILLUMINA	ss3636425136	Oct 12, 2018 (152)
116	ILLUMINA	ss3642062161	Oct 12, 2018 (152)
117	OMUKHERJEE_ADBS	ss3646538369	Oct 12, 2018 (152)
118	URBANLAB	ss3650925113	Oct 12, 2018 (152)
119	ILLUMINA	ss3652337669	Oct 12, 2018 (152)
120	ILLUMINA	ss3652337670	Oct 12, 2018 (152)
121	ILLUMINA	ss3652337671	Oct 12, 2018 (152)
122	ILLUMINA	ss3652337672	Oct 12, 2018 (152)
123	ILLUMINA	ss3652337673	Oct 12, 2018 (152)
124	ILLUMINA	ss3652337674	Oct 12, 2018 (152)
125	ILLUMINA	ss3652337675	Oct 12, 2018 (152)
126	ILLUMINA	ss3652337676	Oct 12, 2018 (152)
127	ILLUMINA	ss3652337677	Oct 12, 2018 (152)
128	ILLUMINA	ss3652337678	Oct 12, 2018 (152)
129	ILLUMINA	ss3652337679	Oct 12, 2018 (152)
130	ILLUMINA	ss3652337680	Oct 12, 2018 (152)
131	ILLUMINA	ss3652337681	Oct 12, 2018 (152)
132	ILLUMINA	ss3652337682	Oct 12, 2018 (152)
133	ILLUMINA	ss3652337683	Oct 12, 2018 (152)
134	ILLUMINA	ss3652337684	Oct 12, 2018 (152)
135	ILLUMINA	ss3652337685	Oct 12, 2018 (152)
136	ILLUMINA	ss3652337686	Oct 12, 2018 (152)
137	ILLUMINA	ss3652337687	Oct 12, 2018 (152)
138	ILLUMINA	ss3652337688	Oct 12, 2018 (152)
139	ILLUMINA	ss3652337689	Oct 12, 2018 (152)
140	ILLUMINA	ss3652337690	Oct 12, 2018 (152)
141	ILLUMINA	ss3652337691	Oct 12, 2018 (152)
142	ILLUMINA	ss3652337692	Oct 12, 2018 (152)
143	ILLUMINA	ss3652337693	Oct 12, 2018 (152)
144	ILLUMINA	ss3653917425	Oct 12, 2018 (152)
145	EGCUT_WGS	ss3684286598	Jul 13, 2019 (153)
146	EVA_DECODE	ss3702845766	Jul 13, 2019 (153)
147	ILLUMINA	ss3725733594	Jul 13, 2019 (153)
148	ACPOP	ss3743072611	Jul 13, 2019 (153)
149	ILLUMINA	ss3744466120	Jul 13, 2019 (153)
150	ILLUMINA	ss3744466121	Jul 13, 2019 (153)
151	ILLUMINA	ss3744466122	Jul 13, 2019 (153)
152	ILLUMINA	ss3744466123	Jul 13, 2019 (153)
153	ILLUMINA	ss3744466124	Jul 13, 2019 (153)
154	ILLUMINA	ss3744466125	Jul 13, 2019 (153)
155	ILLUMINA	ss3744466126	Jul 13, 2019 (153)
156	ILLUMINA	ss3744466127	Jul 13, 2019 (153)
157	ILLUMINA	ss3744466128	Jul 13, 2019 (153)
158	EVA	ss3756111786	Jul 13, 2019 (153)
159	PAGE_CC	ss3772016997	Jul 13, 2019 (153)
160	KHV_HUMAN_GENOMES	ss3821359903	Jul 13, 2019 (153)
161	EVA	ss3825301407	Apr 27, 2020 (154)
162	EVA	ss3825938284	Apr 27, 2020 (154)
163	EVA	ss3835481188	Apr 27, 2020 (154)
164	EVA	ss3841363372	Apr 27, 2020 (154)
165	EVA	ss3846869423	Apr 27, 2020 (154)
166	SGDP_PRJ	ss3888305361	Apr 27, 2020 (154)
167	KRGDB	ss3938432686	Apr 27, 2020 (154)
168	KOGIC	ss3981436489	Apr 27, 2020 (154)
169	FSA-LAB	ss3984156827	Apr 26, 2021 (155)
170	EVA	ss3985856232	Apr 26, 2021 (155)
171	EVA	ss3986081222	Apr 26, 2021 (155)
172	EVA	ss3986802271	Apr 26, 2021 (155)
173	TOPMED	ss5076165819	Apr 26, 2021 (155)
174	TOMMO_GENOMICS	ss5227950594	Apr 26, 2021 (155)
175	EVA	ss5236962739	Apr 26, 2021 (155)
176	1000Genomes	NC_000019.9 - 45411941	Oct 12, 2018 (152)
177	The Avon Longitudinal Study of Parents and Children	NC_000019.9 - 45411941	Oct 12, 2018 (152)
178	Genetic variation in the Estonian population	NC_000019.9 - 45411941	Oct 12, 2018 (152)
179	ExAC	NC_000019.9 - 45411941	Oct 12, 2018 (152)
180	The Danish reference pan genome	NC_000019.9 - 45411941	Apr 27, 2020 (154)
181	gnomAD - Genomes	NC_000019.10 - 44908684	Apr 26, 2021 (155)
182	gnomAD - Exomes	NC_000019.9 - 45411941	Jul 13, 2019 (153)
183	HapMap	NC_000019.10 - 44908684	Apr 27, 2020 (154)
184	KOREAN population from KRGDB	NC_000019.9 - 45411941	Apr 27, 2020 (154)
185	Korean Genome Project	NC_000019.10 - 44908684	Apr 27, 2020 (154)
186	Northern Sweden	NC_000019.9 - 45411941	Jul 13, 2019 (153)
187	The PAGE Study	NC_000019.10 - 44908684	Jul 13, 2019 (153)
188	Ancient Sardinia genome-wide 1240k capture data generation and analysis	NC_000019.9 - 45411941	Apr 26, 2021 (155)
189	Qatari	NC_000019.9 - 45411941	Apr 27, 2020 (154)
190	SGDP_PRJ	NC_000019.9 - 45411941	Apr 27, 2020 (154)
191	Siberian	NC_000019.9 - 45411941	Apr 27, 2020 (154)
192	3.5KJPNv2	NC_000019.9 - 45411941	Apr 26, 2021 (155)
193	TopMed	NC_000019.10 - 44908684	Apr 26, 2021 (155)
194	UK 10K study - Twins	NC_000019.9 - 45411941	Oct 12, 2018 (152)
195	ALFA	NC_000019.10 - 44908684	Apr 26, 2021 (155)
196	ClinVar	RCV000019438.29	Oct 12, 2018 (152)
197	ClinVar	RCV000019447.31	Apr 27, 2020 (154)
198	ClinVar	RCV000019448.34	Apr 26, 2021 (155)
199	ClinVar	RCV000019455.32	Apr 27, 2020 (154)
200	ClinVar	RCV000019456.28	Oct 12, 2018 (152)
201	ClinVar	RCV000019458.26	Apr 27, 2020 (154)
202	ClinVar	RCV000292119.3	Apr 27, 2020 (154)
203	ClinVar	RCV000825286.1	Apr 27, 2020 (154)
204	ClinVar	RCV000826089.1	Apr 27, 2020 (154)
205	ClinVar	RCV000845581.1	Apr 27, 2020 (154)
206	ClinVar	RCV000856604.2	Apr 27, 2020 (154)
207	ClinVar	RCV000991302.1	Apr 27, 2020 (154)
208	ClinVar	RCV001175124.1	Apr 26, 2021 (155)
209	ClinVar	RCV001195807.1	Apr 26, 2021 (155)
210	ClinVar	RCV001262791.1	Apr 26, 2021 (155)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs630496	Sep 19, 2000 (85)
rs61228756	May 26, 2008 (130)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss160670648, ss168243995, ss410828263, ss483834108, ss1698394130	NC_000019.8:50103780:T:C	NC_000019.10:44908683:T:C	(self)
76738719, 42493851, 30024846, 4174066, 4835567, 13406297, 45610080, 16357476, 1082159, 19877743, 40322341, 10754436, 85919901, 42493851, ss228156553, ss237689596, ss481897219, ss484318107, ss491161751, ss491549548, ss536501696, ss661874596, ss713519649, ss780608662, ss782605255, ss836101974, ss974506672, ss994339187, ss1067590770, ss1363326184, ss1578653635, ss1638043657, ss1681037690, ss1693665397, ss1937835821, ss1959869660, ss1959869661, ss1959869662, ss1959869663, ss1959869665, ss1959869666, ss1959869667, ss1959869668, ss1959869669, ss1959869670, ss1959869671, ss1959869672, ss1959869673, ss1959869675, ss1959869676, ss1959869677, ss1959869678, ss1959869679, ss1959869680, ss2029695318, ss2095085222, ss2158238082, ss2391820667, ss2633544198, ss2633544199, ss2633544200, ss2702851377, ss2744090515, ss2750218818, ss2963330113, ss2985144680, ss2985775660, ss3017540728, ss3021911568, ss3021911569, ss3021911570, ss3021911571, ss3021911572, ss3021911573, ss3021911574, ss3021911575, ss3021911576, ss3021911577, ss3021911578, ss3021911579, ss3021911580, ss3021911581, ss3021911582, ss3021911583, ss3021911584, ss3021911585, ss3021911586, ss3021911587, ss3021911588, ss3021911589, ss3021911590, ss3021911591, ss3352320693, ss3625742825, ss3625742826, ss3625742827, ss3625742828, ss3625742829, ss3627941617, ss3631515218, ss3636425136, ss3642062161, ss3646538369, ss3652337669, ss3652337670, ss3652337671, ss3652337672, ss3652337673, ss3652337674, ss3652337675, ss3652337676, ss3652337677, ss3652337678, ss3652337679, ss3652337680, ss3652337681, ss3652337682, ss3652337683, ss3652337684, ss3652337685, ss3652337686, ss3652337687, ss3652337688, ss3652337689, ss3652337690, ss3652337691, ss3652337692, ss3652337693, ss3653917425, ss3684286598, ss3743072611, ss3744466120, ss3744466121, ss3744466122, ss3744466123, ss3744466124, ss3744466125, ss3744466126, ss3744466127, ss3744466128, ss3756111786, ss3825301407, ss3825938284, ss3835481188, ss3841363372, ss3888305361, ss3938432686, ss3984156827, ss3985856232, ss3986081222, ss3986802271, ss5227950594	NC_000019.9:45411940:T:C	NC_000019.10:44908683:T:C	(self)
RCV000019438.29, RCV000019448.34, RCV000019455.32, RCV000019456.28, RCV000019458.26, RCV000292119.3, RCV000825286.1, RCV000826089.1, RCV000845581.1, RCV000991302.1, RCV001175124.1, RCV001195807.1, RCV001262791.1, 541193084, 1701715, 37814490, 1238466, 181977039, 291711483, 11832453994, ss244239676, ss275517967, ss537712916, ss2226012248, ss3028677779, ss3294331438, ss3650925113, ss3702845766, ss3725733594, ss3772016997, ss3821359903, ss3846869423, ss3981436489, ss5076165819, ss5236962739	NC_000019.10:44908683:T:C	NC_000019.10:44908683:T:C	(self)
ss21518782, ss76884559	NT_011109.15:17680158:T:C	NC_000019.10:44908683:T:C	(self)
ss569295, ss803061, ss870163, ss2419938, ss12568607, ss16231123, ss24811489, ss44158325, ss80743998, ss96308980, ss107936537, ss132769779, ss159740185, ss181341884, ss469414605	NT_011109.16:17680158:T:C	NC_000019.10:44908683:T:C	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

416 citations for rs429358

PMID	Title	Author	Year	Journal
1730728	The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia.	Horie Y et al.	1992	The Journal of biological chemistry
2341812	Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity.	Wardell MR et al.	1990	Journal of lipid research
2539388	Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant.	Rall SC Jr et al.	1989	The Journal of clinical investigation
2987927	Nucleotide sequence and structure of the human apolipoprotein E gene.	Paik YK et al.	1985	Proceedings of the National Academy of Sciences of the United States of America
3585172	Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms.	Ordovas JM et al.	1987	Journal of lipid research
3922972	Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.	Das HK et al.	1985	The Journal of biological chemistry
6860421	Atypical familial dysbetalipoproteinemia associated with apolipoprotein phenotype E3/3.	Havel RJ et al.	1983	The Journal of clinical investigation
7263700	Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.	Weisgraber KH et al.	1981	The Journal of biological chemistry
8346443	Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.	Corder EH et al.	1993	Science (New York, N.Y.)
8488843	Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia.	van den Maagdenberg AM et al.	1993	American journal of human genetics
8618665	Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study.	Myers RH et al.	1996	Neurology
8644717	Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City.	Tang MX et al.	1996	American journal of human genetics
9932938	Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury.	Friedman G et al.	1999	Neurology
10213549	Association of apolipoprotein E polymorphism with outcome after head injury.	Teasdale GM et al.	1997	Lancet (London, England)
11835377	Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele.	Mori E et al.	2002	Annals of neurology
11940689	Apolipoprotein E epsilon 4 and short-term recovery from predominantly mild brain injury.	Liberman JN et al.	2002	Neurology
11940706	APOE genotype influences acquisition and recall following traumatic brain injury.	Crawford FC et al.	2002	Neurology
14741101	ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.	DeMattos RB et al.	2004	Neuron
15048896	Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4.	Enzinger C et al.	2004	Annals of neurology
15113403	Current limitations of SNP data from the public domain for studies of complex disorders: a test for ten candidate genes for obesity and osteoporosis.	Dvornyk V et al.	2004	BMC genetics
15157284	Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes.	Long JR et al.	2004	BMC genetics
15172743	ApoE genotype accounts for the vast majority of AD risk and AD pathology.	Raber J et al.	2004	Neurobiology of aging
15184602	Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele.	Caselli RJ et al.	2004	Neurology
15326261	APOE-epsilon4 predicts dementia but not other psychiatric disorders after traumatic brain injury.	Koponen S et al.	2004	Neurology
15557508	Impact of APOE in mild cognitive impairment.	Farlow MR et al.	2004	Neurology
15668424	APOE genotype and cognitive decline in a middle-aged cohort.	Blair CK et al.	2005	Neurology
16595073	Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations.	Savas S et al.	2006	Human genomics
16603077	Variation at APOE and STH loci and Alzheimer's disease.	Zuo L et al.	2006	Behavioral and brain functions
17048007	Association of warfarin dose with genes involved in its action and metabolism.	Wadelius M et al.	2007	Human genetics
17356695	Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality.	Fredriksson J et al.	2007	PloS one
17357073	Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.	Pare G et al.	2007	American journal of human genetics
17434289	Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.	Yu CE et al.	2007	Genomics
17456829	Evaluation of genetic factors for warfarin dose prediction.	Caldwell MD et al.	2007	Clinical medicine & research
17672902	Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes.	Kaushal R et al.	2007	BMC medical genetics
17903299	A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.	Kathiresan S et al.	2007	BMC medical genetics
18034366	Lack of replication of genetic associations with human longevity.	Novelli V et al.	2008	Biogerontology
18196181	Correction of population stratification in large multi-ethnic association studies.	Serre D et al.	2008	PloS one
18216863	Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.	Rhodes B et al.	2008	Genes and immunity
18254975	Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.	Seip RL et al.	2008	Nutrition & metabolism
18275964	Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study.	Chamberlain AM et al.	2008	Atherosclerosis
18378515	APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels.	Klos K et al.	2008	Human molecular genetics
18448515	Evidence that the gene encoding insulin degrading enzyme influences human lifespan.	Hong MG et al.	2008	Human molecular genetics
18513389	New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.	Penco S et al.	2008	BMC bioinformatics
18574025	The largest prospective warfarin-treated cohort supports genetic forecasting.	Wadelius M et al.	2009	Blood
18583979	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	Allen NC et al.	2008	Nature genetics
18596683	Dosing algorithms to predict warfarin maintenance dose in Caucasians and African Americans.	Schelleman H et al.	2008	Clinical pharmacology and therapeutics
18603647	Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.	Simoni M et al.	2008	Human reproduction update
18678618	Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.	Gaulton KJ et al.	2008	Diabetes
18823527	A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.	Abraham R et al.	2008	BMC medical genomics
18941475	On Jim Watson's APOE status: genetic information is hard to hide.	Nyholt DR et al.	2009	European journal of human genetics
18974842	Gender differences in genetic risk profiles for cardiovascular disease.	Silander K et al.	2008	PloS one
18976728	Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.	Bertram L et al.	2008	American journal of human genetics
19001172	Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci.	Lee JH et al.	2008	Archives of neurology
19014573	Application of two machine learning algorithms to genetic association studies in the presence of covariates.	Nonyane BA et al.	2008	BMC genetics
19058936	A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females.	He LN et al.	2009	Maturitas
19118814	Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.	Beecham GW et al.	2009	American journal of human genetics
19131662	A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.	Wang X et al.	2009	Stroke
19172988	The complex interaction between APOE promoter and AD: an Italian case-control study.	Bizzarro A et al.	2009	European journal of human genetics
19262956	GAB2 gene does not modify the risk of Alzheimer's disease in Spanish APOE 4 carriers.	Ramirez-Lorca R et al.	2009	The journal of nutrition, health & aging
19263529	Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.	Zee RY et al.	2009	Clinica chimica acta; international journal of clinical chemistry
19285141	Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response.	Liu J et al.	2009	NeuroImage
19299407	Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.	Lanktree MB et al.	2009	Journal of lipid research
19336475	Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.	Drenos F et al.	2009	Human molecular genetics
19377787	Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals.	Souza DR et al.	2009	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
19501493	A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study.	Junyent M et al.	2010	Nutrition, metabolism, and cardiovascular diseases
19541455	Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients.	Clark D et al.	2009	European psychiatry
19554612	APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.	Bekris LM et al.	2010	American journal of medical genetics. Part B, Neuropsychiatric genetics
19602472	Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study.	Ren C et al.	2010	Journal of epidemiology and community health
19653016	Sequence variation in SORL1 and dementia risk in Swedes.	Reynolds CA et al.	2010	Neurogenetics
19667110	Identification of genetic variants associated with response to statin therapy.	Mega JL et al.	2009	Arteriosclerosis, thrombosis, and vascular biology
19668339	Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.	Potkin SG et al.	2009	PloS one
19734902	Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.	Harold D et al.	2009	Nature genetics
19756043	A simple and efficient algorithm for genome-wide homozygosity analysis in disease.	Liu W et al.	2009	Molecular systems biology
19766542	The FAS gene, brain volume, and disease progression in Alzheimer's disease.	Erten-Lyons D et al.	2010	Alzheimer's & dementia
19787382	Introduction to the DISRUPT postprandial database: subjects, studies and methodologies.	Jackson KG et al.	2010	Genes & nutrition
19818961	Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm.	Golledge J et al.	2010	Atherosclerosis
19884647	Air pollution, obesity, genes and cellular adhesion molecules.	Madrigano J et al.	2010	Occupational and environmental medicine
19913121	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	Talmud PJ et al.	2009	American journal of human genetics
19936222	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.	Chasman DI et al.	2009	PLoS genetics
19951432	Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.	Ronald J et al.	2009	Lipids in health and disease
20082485	Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women.	Báez S et al.	2010	World journal of gastroenterology
20100581	Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort.	Shen L et al.	2010	NeuroImage
20167577	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	Reynolds CA et al.	2010	Human molecular genetics
20308031	Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer.	Kato I et al.	2010	Cancer epidemiology
20381870	Progression of geographic atrophy and genotype in age-related macular degeneration.	Klein ML et al.	2010	Ophthalmology
20396431	Genotyping sleep disorders patients.	Kripke DF et al.	2010	Psychiatry investigation
20406466	Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey.	Chang MH et al.	2010	BMC medical genetics
20429872	Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study.	Ariza MJ et al.	2010	BMC medical genetics
20451875	Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.	Saykin AJ et al.	2010	Alzheimer's & dementia
20460622	Genome-wide analysis of genetic loci associated with Alzheimer disease.	Seshadri S et al.	2010	JAMA
20467002	Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls.	Kring SI et al.	2010	Psychosomatic medicine
20498921	APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men.	Ken-Dror G et al.	2010	Molecular medicine (Cambridge, Mass.)
20549395	Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies.	Cornelis MC et al.	2010	Current psychiatry reports
20556870	CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies.	Johnson AD et al.	2010	Genetics in medicine
20565774	Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.	Cross DS et al.	2010	BMC genetics
20569235	HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.	Jazwinski SM et al.	2010	Aging cell
20663622	A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India.	Singh M et al.	2010	Maturitas
20682755	A pilot study of gene/gene and gene/environment interactions in Alzheimer disease.	Ghebranious N et al.	2011	Clinical medicine & research
20822524	Isoform of APOE with retained intron 3; quantitation and identification of an associated single nucleotide polymorphism.	Dieter LS et al.	2010	Molecular neurodegeneration
20832063	Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.	Lu Y et al.	2010	Atherosclerosis
20885792	Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.	Naj AC et al.	2010	PLoS genetics
20946940	Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome.	Patel A et al.	2011	Neuroscience letters
21045241	Age-related macular degeneration: genetic and environmental factors of disease.	Chen Y et al.	2010	Molecular interventions
21054877	Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994.	Ned RM et al.	2010	BMC medical genetics
21123754	Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.	Kim S et al.	2011	Neurology
21124753	Alzheimer's disease: diagnostics, prognostics and the road to prevention.	Grossman I et al.	2010	The EPMA journal
21146954	Genes and abdominal aortic aneurysm.	Hinterseher I et al.	2011	Annals of vascular surgery
21196064	Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease.	Bekris LM et al.	2011	Neurobiology of aging
21215387	IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children.	Taylor AE et al.	2011	Biological psychiatry
21228733	Genetic and nongenetic factors associated with warfarin dose requirements in Egyptian patients.	Shahin MH et al.	2011	Pharmacogenetics and genomics
21263195	An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease.	Lescai F et al.	2011	Journal of Alzheimer's disease
21285406	Low-density lipoprotein cholesterol and the risk of cancer: a mendelian randomization study.	Benn M et al.	2011	Journal of the National Cancer Institute
21297263	Genetic association of sequence variants near AGER/NOTCH4 and dementia.	Bennet AM et al.	2011	Journal of Alzheimer's disease
21324458	Association of gene variants with lipid levels in response to fenofibrate is influenced by metabolic syndrome status.	Feitosa MF et al.	2011	Atherosclerosis
21379329	Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.	Wijsman EM et al.	2011	PLoS genetics
21418511	Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.	Deelen J et al.	2011	Aging cell
21441355	Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants.	Takeuchi F et al.	2011	Genome research
21450715	High-dimensional pharmacogenetic prediction of a continuous trait using machine learning techniques with application to warfarin dose prediction in African Americans.	Cosgun E et al.	2011	Bioinformatics (Oxford, England)
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27585988	Structured sparse CCA for brain imaging genetics via graph OSCAR.	Du L et al.	2016	BMC systems biology
27589735	A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification.	Ponasenko AV et al.	2016	International journal of molecular sciences
27662287	Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.	Darst BF et al.	2017	Journal of Alzheimer's disease
27707806	Replication of Genome-Wide Association Study Findings of Longevity in White, African American, and Hispanic Women: The Women's Health Initiative.	Shadyab AH et al.	2017	The journals of gerontology. Series A, Biological sciences and medical sciences
27716211	A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.	Beaney KE et al.	2016	Cardiovascular diabetology
27724906	Association of apolipoprotein E polymorphism with plasma lipid disorders, independent of obesity-related traits in Vietnamese children.	Hanh NT et al.	2016	Lipids in health and disease
27783031	Association of MTHFR, SLC19A1 Genetic Polymorphism, Serum Folate, Vitamin B<sub>12</sub> and Hcy Status with Cognitive Functions in Chinese Adults.	Cai C et al.	2016	Nutrients
27796860	Genetic Risk Factors for Ischemic and Hemorrhagic Stroke.	Chauhan G et al.	2016	Current cardiology reports
27798356	Lack of replication of associations between multiple genetic polymorphisms and endurance athlete status in Japanese population.	Yvert T et al.	2016	Physiological reports
27805002	Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer's Disease.	Chen YC et al.	2016	Scientific reports
27814994	The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.	Gan-Or Z et al.	2017	Neurobiology of aging
27896962	ADAPTIVE TESTING OF SNP-BRAIN FUNCTIONAL CONNECTIVITY ASSOCIATION VIA A MODULAR NETWORK ANALYSIS.	Gao C et al.	2017	Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
27979356	Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.	Irwin DJ et al.	2017	The Lancet. Neurology
28034305	SORL1 gene, plasma biomarkers, and the risk of Alzheimer's disease for the Han Chinese population in Taiwan.	Chou CT et al.	2016	Alzheimer's research & therapy
28050343	Brain insulin resistance deteriorates cognition by altering the topological features of brain networks.	Su F et al.	2017	NeuroImage. Clinical
28086795	Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study.	Fawzy MS et al.	2017	BMC cardiovascular disorders
28094792	Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer's Disease.	Urfer-Buchwalder A et al.	2017	Scientific reports
28123423	Apolipoprotein E polymorphisms increase the risk of post-stroke depression.	Li XB et al.	2016	Neural regeneration research
28167353	Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants.	Shahid SU et al.	2017	Atherosclerosis
28189700	CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.	Fardo DW et al.	2017	Experimental gerontology
28253266	Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis.	Wu X et al.	2017	PloS one
28388928	SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature.	Bokharaeian B et al.	2017	Journal of biomedical semantics
28399184	Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease.	Huertas I et al.	2017	PloS one
28464262	A tale of agriculturalists and hunter-gatherers: Exploring the thrifty genotype hypothesis in native South Americans.	Reales G et al.	2017	American journal of physical anthropology
28480219	Apolipoprotein E Genotype in Very Preterm Neonates with Intrauterine Growth Restriction: An Analysis of the German Neonatal Network Cohort.	Norda S et al.	2017	BioMed research international
28558900	Effect of CLU and PICALM polymorphisms on AD risk: A study from south India.	Shankarappa BM et al.	2017	Asian journal of psychiatry
28605058	Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia.	Ward KM et al.	2017	Pharmacotherapy
28645497	An association between polymorphisms within the APOE gene and concussion aetiology in rugby union players.	Abrahams S et al.	2018	Journal of science and medicine in sport
28650998	Functional annotation of Alzheimer's disease associated loci revealed by GWASs.	Han Z et al.	2017	PloS one
28672022	APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.	Yu L et al.	2017	PloS one
28686695	Coronary artery disease-associated genetic variants and biomarkers of inflammation.	Christiansen MK et al.	2017	PloS one
28705542	Effect of Coronary Artery Disease risk SNPs on serum cytokine levels and cytokine imbalance in Premature Coronary Artery Disease.	Ansari WM et al.	2019	Cytokine
28720344	APOE genotype associates with food consumption and body composition to predict dyslipidaemia in Brazilian adults with normal-weight obesity syndrome.	Franco LP et al.	2018	Clinical nutrition (Edinburgh, Scotland)
28727855	Association of APOE gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans.	Larifla L et al.	2017	PloS one
28800603	Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort.	Arpawong TE et al.	2017	PloS one
28812116	SLCO1B1 521T > C polymorphism associated with rosuvastatin-induced myotoxicity in Chinese coronary artery disease patients: a nested case-control study.	Liu JE et al.	2017	European journal of clinical pharmacology
28824412	ApoE rs429358 and rs7412 Polymorphism and Gender Differences of Serum Lipid Profile and Cognition in Aging Chinese Population.	Zhen J et al.	2017	Frontiers in aging neuroscience
28983317	Genetic Analysis of Mitochondrial Ribosomal Proteins and Cognitive Aging in Postmenopausal Women.	Mozhui K et al.	2017	Frontiers in genetics
29059476	Influence of Apolipoprotein E polymorphism on susceptibility of Wilson disease.	Roy S et al.	2018	Annals of human genetics
29070790	Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty.	Du L et al.	2017	Scientific reports
29074556	Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population.	Zhao LL et al.	2017	Bioscience reports
29125573	Tailoring Nutritional Advice for Mexicans Based on Prevalence Profiles of Diet-Related Adaptive Gene Polymorphisms.	Ojeda-Granados C et al.	2017	Journal of personalized medicine
29201112	Association of Warfarin Therapy with <i>APOE</i> and <i>VKORC1</i> Genes Polymorphism in Iranian Population.	Rafiee S et al.	2017	Iranian journal of pharmaceutical research
29213291	Apolipoprotein E polymorphism and the risk of aneurysmal subarachnoid hemorrhage in a South Indian population.	Suvatha A et al.	2017	Cellular & molecular biology letters
29263008	Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.	Guerreiro R et al.	2018	The Lancet. Neurology
29340220	Multilocus Analysis of Genetic Susceptibility to Myocardial Infarction in Russians: Replication Study.	Kukava NG et al.	2017	Acta naturae
29370207	APOEε4 and slow wave sleep in older adults.	Tranah GJ et al.	2018	PloS one
29395286	An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk.	Rao S et al.	2018	Neurobiology of aging
29532745	Association of smoking but not HLA-DRB1*15:01, APOE or body mass index with brain atrophy in early multiple sclerosis.	Graetz C et al.	2019	Multiple sclerosis (Houndmills, Basingstoke, England)
29534716	Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals.	Nordestgaard LT et al.	2018	BMC medicine
29712557	Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors.	Shatwan IM et al.	2018	Lipids in health and disease
29764032	[Genes polymorphism of BIN1 and ApoE in patients with amnestic mild cognitive impairment from Enshi Tujia area].	Chen J et al.	2018	Zhonghua yi xue za zhi
29776682	The impact of Apolipoprotein E alleles on cognitive performance in patients with Parkinson's disease.	Pierzchlińska A et al.	2018	Neurologia i neurochirurgia polska
29795275	Phenotype and genotype predictors of BMI variability among European adults.	Goni L et al.	2018	Nutrition & diabetes
29851526	The role of apolipoprotein E (rs7412 and rs429358) in age-related macular degeneration.	Liutkeviciene R et al.	2018	Ophthalmic genetics
29892926	The relationship between genetic polymorphisms in apolipoprotein E (ApoE) gene and osteonecrosis of the femoral head induced by steroid in Chinese Han population.	Yuan L et al.	2018	Genes & genomics
29899525	Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.	Klimentidis YC et al.	2018	International journal of obesity (2005)
29932521	Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia.	Pawlikowska L et al.	2018	Molecular genetics & genomic medicine
29942042	A decade in psychiatric GWAS research.	Horwitz T et al.	2019	Molecular psychiatry
29972410	Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants.	Pereira A et al.	2018	Arquivos brasileiros de cardiologia
29996665	The Effect of the Relationship of APOE Polymorphisms and Cerebral Vasospasm on Functional Outcomes in Children With Traumatic Brain Injury.	Reuter-Rice K et al.	2018	Biological research for nursing
30088610	An association study of FOXO3 variant and longevity.	Silva-Sena GG et al.	2018	Genetics and molecular biology
30137607	Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC]).	Park JY et al.	2019	Translational behavioral medicine
30182779	Genetic susceptibility to cerebrovascular disease: A systematic review.	Griessenauer CJ et al.	2018	Journal of cerebral blood flow and metabolism
30202567	Genetic findings in sport-related concussions: potential for individualized medicine?	McDevitt J et al.	2017	Concussion (London, England)
30235358	Role of Apolipoprotein E gene polymorphism in the risk of familial hypercholesterolemia: a case-control study.	Almigbal TH et al.	2018	Acta biochimica Polonica
30338758	First Bosnian Study of the Relationship between APOE rs7412 and rs429358 Variants and Pregnancy Loss.	Adler G et al.	2018	Folia biologica
30462377	Independent associations of TOMM40 and APOE variants with body mass index.	Kulminski AM et al.	2019	Aging cell
30478798	Childhood trauma interacts with ApoE to influence neurocognitive function in women living with HIV.	Womersley JS et al.	2019	Journal of neurovirology
30571812	Additional value of a combined genetic risk score to standard cardiovascular stratification.	Pereira A et al.	2018	Genetics and molecular biology
30584432	Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study.	Daneshpour MS et al.	2018	International journal of endocrinology and metabolism
30660866	Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line.	Schmid B et al.	2019	Stem cell research
30665447	Dementia with Lewy bodies: an update and outlook.	Outeiro TF et al.	2019	Molecular neurodegeneration
30679475	The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study.	Karjalainen JP et al.	2019	Scientific reports
30788380	Association study between DNA methylation and genetic variation of <i>APOE</i> gene with the risk of coronary artery disease.	Ghaznavi H et al.	2018	Molecular biology research communications
30819100	10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors.	Tindale LC et al.	2019	BMC geriatrics
31054363	Association of ApoE haplotype with clinical evidence of pituitary adenoma.	Sidaraite A et al.	2019	Gene
31126849	Role of APOE and IL18RAP gene polymorphisms in cervical spondylotic myelopathy in Indian population.	Diptiranjan S et al.	2019	Journal of clinical neuroscience
31127079	Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment.	Chaudhury S et al.	2019	Translational psychiatry
31134487	Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson's Disease: A Study from Eastern India.	Pal P et al.	2019	Neuromolecular medicine
31189032	Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile.	Lerche S et al.	2019	Movement disorders
31192002	Multiple Gene Polymorphisms Associated with Exfoliation Syndrome in the Uygur Population.	Ma YN et al.	2019	Journal of ophthalmology
31381519	APOE ɛ4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke.	Werden E et al.	2019	Journal of Alzheimer's disease
31413261	A meta-analysis of genome-wide association studies identifies multiple longevity genes.	Deelen J et al.	2019	Nature communications
31469155	The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer's disease.	Santos LRD et al.	2020	Genetics and molecular biology
31480637	Impact of the <i>Apolipoprotein E</i> (epsilon) Genotype on Cardiometabolic Risk Markers and Responsiveness to Acute and Chronic Dietary Fat Manipulation.	Rathnayake KM et al.	2019	Nutrients
31505070	Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.	Iwaki H et al.	2019	Movement disorders
31523375	Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults.	Camargos EF et al.	2019	International journal of molecular epidemiology and genetics
31559922	APOE polymorphism is associated with blood lipid and serum uric acid metabolism in hypertension or coronary heart disease in a Chinese population.	Wang C et al.	2019	Pharmacogenomics
31585025	The influence of gene polymorphisms on postprandial triglyceride response after oral fat tolerance test meal in patients with diabetes mellitus.	Gavra P et al.	2019	International journal of clinical practice
31654486	The association study of lipid metabolism gene polymorphisms with AMD identifies a protective role for APOE-E2 allele in the wet form in a Northern Spanish population.	Fernández-Vega B et al.	2020	Acta ophthalmologica
31767813	Connection between polymorphisms in <i>HTR2A</i>, <i>TPH2</i>, <i>BDNF</i>, <i>TOMM40</i> genes and the successful mastering of human-computer interfaces.	Turovsky YA et al.	2019	Journal of genetics
31833563	A novel multi-locus genetic risk score identifies patients with higher risk of generalized aggressive periodontitis.	Li W et al.	2020	Journal of periodontology
31854268	Impact of <i>CYP2C9</i>, <i>VKORC1</i>, <i>ApoE</i> and <i>ABCB1</i> polymorphisms on stable warfarin dose requirements in elderly Chinese patients.	Li W et al.	2020	Pharmacogenomics
31861518	Genetic Associations with Aging Muscle: A Systematic Review.	Pratt J et al.	2019	Cells
32211503	Genetic and regulatory architecture of Alzheimer's disease in the <i>APOE</i> region.	Kulminski AM et al.	2020	Alzheimer's & dementia (Amsterdam, Netherlands)
32326111	Role of Genetic Variations in the Hepatic Handling of Drugs.	Marin JJG et al.	2020	International journal of molecular sciences
32327994	A Pharmacogenetically Guided Acenocoumarol Dosing Algorithm for Chilean Patients: A Discovery Cohort Study.	Roco A et al.	2020	Frontiers in pharmacology
32352830	Combined genetic influences on episodic memory decline in older adults without dementia.	Laukka EJ et al.	2020	Neuropsychology
32358224	Is <i>APOE</i> ε4 associated with cognitive performance in early MS?	Engel S et al.	2020	Neurology(R) neuroimmunology & neuroinflammation
32622117	Trace elements and APOE polymorphisms in pregnant women and their new-borns.	Trdin A et al.	2020	Environment international
32647408	Association of Common Single Nucleotide Polymorphisms of Candidate Genes with Gallstone Disease: A Meta-Analysis.	Chauhan T et al.	2020	Indian journal of clinical biochemistry
32676622	Genetic associations for two biological age measures point to distinct aging phenotypes.	Kuo CL et al.	2020	medRxiv
32713352	Does polymorphisms in <i>PPAR</i> and <i>APOE</i> genes modify associations between fatty acid desaturase (<i>FADS</i>), <i>n</i>-3 long-chain PUFA and cardiometabolic markers in 8-11-year-old Danish children?	Damsgaard CT et al.	2021	The British journal of nutrition
32867607	Are <i>KIF6</i> and <i>APOE</i> polymorphisms associated with power and endurance athletes?	Wojciechowicz B et al.	2021	European journal of sport science
32891149	The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population.	Wu H et al.	2020	Lipids in health and disease
32914893	Association of PICALM with Cognitive Impairment in Parkinson's Disease.	Periñán MT et al.	2021	Movement disorders
32924542	Genetic Analysis of Patients With Sickle Cell Anemia and Stroke Before 4 Years of Age Suggest an Important Role for Apoliprotein E.	Brewin JN et al.	2020	Circulation. Genomic and precision medicine
32985495	Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression.	Li W et al.	2020	Medical science monitor
33057949	Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study).	Alavez-Rubio JS et al.	2021	Molecular neurobiology
33059023	Association of Apolipoprotein E gene polymorphism with the risk of T2DM and obesity among Egyptian subjects.	Galal AA et al.	2021	Gene
33111402	Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease.	Tan MMX et al.	2021	Movement disorders
33163038	Lack of association between genetic variants in the 19q13.32 region and CHD risk in the Algerian population: a population-based nested case-control study.	Boulenouar H et al.	2020	African health sciences
33210016	Baseline characteristics and age-related macular degeneration in participants of the "ASPirin in Reducing Events in the Elderly" (ASPREE)-AMD trial.	Robman LD et al.	2020	Contemporary clinical trials communications
33223668	Association of <i>APOE</i> Gene Polymorphism with Stroke Patients from Rural Eastern India.	Ganaie HA et al.	2020	Annals of Indian Academy of Neurology
33285739	The association study of Apolipoprotein E polymorphisms and chronic obstructive pulmonary disease in the Chinese population: A case-control study.	Zhang Y et al.	2020	Medicine
33287609	"Association of <i>APOE</i> gene polymorphisms with primary open angle glaucoma in Brazilian patients".	Occhiutto ML et al.	2021	Ophthalmic genetics
33347879	Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease.	Jamialahmadi O et al.	2021	Gastroenterology
33467888	Evaluation of <i>APOE</i> polymorphisms and the risk for age-related macular degeneration in a Southeastern Brazilian population.	Viturino MG et al.	2021	Experimental biology and medicine (Maywood, N.J.)
33663605	Genome-wide epistasis analysis for Alzheimer's disease and implications for genetic risk prediction.	Wang H et al.	2021	Alzheimer's research & therapy
33730676	COVID-19 enters the expanding network of apolipoprotein E4-related pathologies.	Gkouskou K et al.	2021	Redox biology

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dbSNP Short Genetic Variations

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Reference SNP (rs) Report

rs429358