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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs25487

Current Build 155

Released April 9, 2021

Organism
Homo sapiens
Position
chr19:43551574 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
T>C / T>G
Variation Type
SNV Single Nucleotide Variation
Frequency
T=0.280940 (74362/264690, TOPMED)
T=0.319382 (79995/250468, GnomAD_exome)
T=0.344122 (76976/223688, ALFA) (+ 22 more)
T=0.284966 (39922/140094, GnomAD)
T=0.316596 (38272/120886, ExAC)
T=0.22764 (17915/78698, PAGE_STUDY)
T=0.25322 (4244/16760, 8.3KJPN)
T=0.29079 (3782/13006, GO-ESP)
T=0.2604 (1304/5008, 1000G)
T=0.3246 (1454/4480, Estonian)
T=0.3542 (1365/3854, ALSPAC)
T=0.3743 (1388/3708, TWINSUK)
T=0.2362 (692/2930, KOREAN)
T=0.2526 (477/1888, HapMap)
T=0.2407 (441/1832, Korea1K)
T=0.352 (351/998, GoNL)
T=0.251 (198/788, PRJEB37584)
T=0.243 (146/600, NorthernSweden)
T=0.286 (168/587, Vietnamese)
T=0.391 (209/534, MGP)
T=0.192 (97/506, SGDP_PRJ)
T=0.331 (100/302, FINRISK)
T=0.208 (45/216, Qatari)
T=0.17 (7/42, Siberian)
T=0.25 (10/40, GENOME_DK)
Clinical Significance
Reported in ClinVar
Gene : Consequence
XRCC1 : Missense Variant
Publications
295 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 19 NC_000019.10:g.43551574T>C
GRCh38.p13 chr 19 NC_000019.10:g.43551574T>G
GRCh37.p13 chr 19 NC_000019.9:g.44055726T>C
GRCh37.p13 chr 19 NC_000019.9:g.44055726T>G
XRCC1 RefSeqGene (LRG_784) NG_033799.1:g.29005A>G
XRCC1 RefSeqGene (LRG_784) NG_033799.1:g.29005A>C
Gene: XRCC1, X-ray repair cross complementing 1 (minus strand)
Molecule type Change Amino acid[Codon] SO Term
XRCC1 transcript NM_006297.3:c.1196A>G Q [CAG] > R [CGG] Coding Sequence Variant
DNA repair protein XRCC1 NP_006288.2:p.Gln399Arg Q (Gln) > R (Arg) Missense Variant
XRCC1 transcript NM_006297.3:c.1196A>C Q [CAG] > P [CCG] Coding Sequence Variant
DNA repair protein XRCC1 NP_006288.2:p.Gln399Pro Q (Gln) > P (Pro) Missense Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: C (allele ID: 227806 )
ClinVar Accession Disease Names Clinical Significance
RCV000660796.1 carboplatin response - Efficacy Drug-Response
RCV000660797.1 cisplatin response - Efficacy Drug-Response
RCV000660798.1 oxaliplatin response - Efficacy Drug-Response
RCV000660799.1 platinum response - Efficacy Drug-Response
RCV000660800.1 Platinum compounds response - Efficacy Drug-Response

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 223688 T=0.344122 C=0.655878
European Sub 188668 T=0.357623 C=0.642377
African Sub 8534 T=0.1610 C=0.8390
African Others Sub 304 T=0.115 C=0.885
African American Sub 8230 T=0.1627 C=0.8373
Asian Sub 6340 T=0.2491 C=0.7509
East Asian Sub 4490 T=0.2575 C=0.7425
Other Asian Sub 1850 T=0.2286 C=0.7714
Latin American 1 Sub 832 T=0.264 C=0.736
Latin American 2 Sub 1112 T=0.2725 C=0.7275
South Asian Sub 290 T=0.372 C=0.628
Other Sub 17912 T=0.33050 C=0.66950


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 T=0.280940 C=0.719060
gnomAD - Exomes Global Study-wide 250468 T=0.319382 C=0.680618
gnomAD - Exomes European Sub 134564 T=0.349826 C=0.650174
gnomAD - Exomes Asian Sub 48992 T=0.31654 C=0.68346
gnomAD - Exomes American Sub 34556 T=0.26473 C=0.73527
gnomAD - Exomes African Sub 16186 T=0.14531 C=0.85469
gnomAD - Exomes Ashkenazi Jewish Sub 10056 T=0.38236 C=0.61764
gnomAD - Exomes Other Sub 6114 T=0.3382 C=0.6618
gnomAD - Genomes Global Study-wide 140094 T=0.284966 C=0.715034
gnomAD - Genomes European Sub 75862 T=0.35082 C=0.64918
gnomAD - Genomes African Sub 41990 T=0.14980 C=0.85020
gnomAD - Genomes American Sub 13644 T=0.31318 C=0.68682
gnomAD - Genomes Ashkenazi Jewish Sub 3322 T=0.3989 C=0.6011
gnomAD - Genomes East Asian Sub 3128 T=0.2657 C=0.7343
gnomAD - Genomes Other Sub 2148 T=0.2742 C=0.7258
ExAC Global Study-wide 120886 T=0.316596 C=0.683404
ExAC Europe Sub 72972 T=0.35079 C=0.64921
ExAC Asian Sub 25132 T=0.31836 C=0.68164
ExAC American Sub 11556 T=0.25087 C=0.74913
ExAC African Sub 10328 T=0.14349 C=0.85651
ExAC Other Sub 898 T=0.325 C=0.675
The PAGE Study Global Study-wide 78698 T=0.22764 C=0.77236
The PAGE Study AfricanAmerican Sub 32514 T=0.15889 C=0.84111
The PAGE Study Mexican Sub 10808 T=0.26591 C=0.73409
The PAGE Study Asian Sub 8318 T=0.2614 C=0.7386
The PAGE Study PuertoRican Sub 7918 T=0.2808 C=0.7192
The PAGE Study NativeHawaiian Sub 4534 T=0.2883 C=0.7117
The PAGE Study Cuban Sub 4230 T=0.3054 C=0.6946
The PAGE Study Dominican Sub 3828 T=0.2197 C=0.7803
The PAGE Study CentralAmerican Sub 2450 T=0.2984 C=0.7016
The PAGE Study SouthAmerican Sub 1982 T=0.3174 C=0.6826
The PAGE Study NativeAmerican Sub 1260 T=0.2944 C=0.7056
The PAGE Study SouthAsian Sub 856 T=0.359 C=0.641
8.3KJPN JAPANESE Study-wide 16760 T=0.25322 C=0.74678
GO Exome Sequencing Project Global Study-wide 13006 T=0.29079 C=0.70921
GO Exome Sequencing Project European American Sub 8600 T=0.3603 C=0.6397
GO Exome Sequencing Project African American Sub 4406 T=0.1550 C=0.8450
1000Genomes Global Study-wide 5008 T=0.2604 C=0.7396
1000Genomes African Sub 1322 T=0.1104 C=0.8896
1000Genomes East Asian Sub 1008 T=0.2351 C=0.7649
1000Genomes Europe Sub 1006 T=0.3658 C=0.6342
1000Genomes South Asian Sub 978 T=0.344 C=0.656
1000Genomes American Sub 694 T=0.313 C=0.687
Genetic variation in the Estonian population Estonian Study-wide 4480 T=0.3246 C=0.6754
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 T=0.3542 C=0.6458
UK 10K study - Twins TWIN COHORT Study-wide 3708 T=0.3743 C=0.6257
KOREAN population from KRGDB KOREAN Study-wide 2930 T=0.2362 C=0.7638, G=0.0000
HapMap Global Study-wide 1888 T=0.2526 C=0.7474
HapMap American Sub 766 T=0.332 C=0.668
HapMap African Sub 692 T=0.136 C=0.864
HapMap Asian Sub 254 T=0.260 C=0.740
HapMap Europe Sub 176 T=0.358 C=0.642
Korean Genome Project KOREAN Study-wide 1832 T=0.2407 C=0.7593
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 T=0.352 C=0.648
CNV burdens in cranial meningiomas Global Study-wide 788 T=0.251 C=0.749
CNV burdens in cranial meningiomas CRM Sub 788 T=0.251 C=0.749
Northern Sweden ACPOP Study-wide 600 T=0.243 C=0.757
A Vietnamese Genetic Variation Database Global Study-wide 587 T=0.286 C=0.714
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 T=0.391 C=0.609
SGDP_PRJ Global Study-wide 506 T=0.192 C=0.808
FINRISK Finnish from FINRISK project Study-wide 302 T=0.331 C=0.669
Qatari Global Study-wide 216 T=0.208 C=0.792
Siberian Global Study-wide 42 T=0.17 C=0.83
The Danish reference pan genome Danish Study-wide 40 T=0.25 C=0.75
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement T= C G
GRCh38.p13 chr 19 NC_000019.10:g.43551574= NC_000019.10:g.43551574T>C NC_000019.10:g.43551574T>G
GRCh37.p13 chr 19 NC_000019.9:g.44055726= NC_000019.9:g.44055726T>C NC_000019.9:g.44055726T>G
XRCC1 RefSeqGene (LRG_784) NG_033799.1:g.29005= NG_033799.1:g.29005A>G NG_033799.1:g.29005A>C
XRCC1 transcript NM_006297.3:c.1196= NM_006297.3:c.1196A>G NM_006297.3:c.1196A>C
XRCC1 transcript NM_006297.2:c.1196= NM_006297.2:c.1196A>G NM_006297.2:c.1196A>C
DNA repair protein XRCC1 NP_006288.2:p.Gln399= NP_006288.2:p.Gln399Arg NP_006288.2:p.Gln399Pro
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

137 SubSNP, 25 Frequency, 5 ClinVar submissions
No Submitter Submission ID Date (Build)
1 OEFNER ss28206 Feb 22, 2000 (71)
2 UWGC ss3254965 Sep 28, 2001 (100)
3 SC_JCM ss3655942 Sep 28, 2001 (100)
4 EGP_SNPS ss4473996 Jul 03, 2002 (106)
5 YUSUKE ss5003825 Aug 28, 2002 (108)
6 SNP500CANCER ss5586970 Jul 02, 2003 (116)
7 WI_SSAHASNP ss12469368 Jul 11, 2003 (116)
8 BCM_SSAHASNP ss14722093 Dec 05, 2003 (119)
9 SSAHASNP ss21536778 Apr 05, 2004 (121)
10 APPLERA_GI ss48405013 Mar 13, 2006 (126)
11 ILLUMINA ss74891848 Dec 06, 2007 (129)
12 CGM_KYOTO ss76863650 Dec 06, 2007 (129)
13 SI_EXO ss76892866 Dec 06, 2007 (129)
14 HGSV ss81579111 Dec 14, 2007 (130)
15 HGSV ss82161334 Dec 14, 2007 (130)
16 HGSV ss84461363 Dec 14, 2007 (130)
17 CANCER-GENOME ss86342741 Mar 23, 2008 (129)
18 BCMHGSC_JDW ss90981936 Mar 24, 2008 (129)
19 HUMANGENOME_JCVI ss96268642 Feb 04, 2009 (130)
20 BGI ss106056339 Feb 04, 2009 (130)
21 1000GENOMES ss111404487 Jan 25, 2009 (130)
22 1000GENOMES ss115168764 Jan 25, 2009 (130)
23 ILLUMINA-UK ss117713217 Feb 14, 2009 (130)
24 KRIBB_YJKIM ss119339873 Dec 01, 2009 (131)
25 ENSEMBL ss136259212 Dec 01, 2009 (131)
26 ENSEMBL ss137687943 Dec 01, 2009 (131)
27 GMI ss155923758 Dec 01, 2009 (131)
28 SEATTLESEQ ss159740042 Dec 01, 2009 (131)
29 COMPLETE_GENOMICS ss168227465 Jul 04, 2010 (132)
30 COMPLETE_GENOMICS ss169801689 Jul 04, 2010 (132)
31 ILLUMINA ss173387757 Jul 04, 2010 (132)
32 BUSHMAN ss203762255 Jul 04, 2010 (132)
33 BCM-HGSC-SUB ss208533173 Jul 04, 2010 (132)
34 1000GENOMES ss228151066 Jul 14, 2010 (132)
35 1000GENOMES ss237685541 Jul 15, 2010 (132)
36 1000GENOMES ss243889121 Jul 15, 2010 (132)
37 ILLUMINA ss244291045 Jul 04, 2010 (132)
38 BL ss255689616 May 09, 2011 (134)
39 GMI ss283219242 May 04, 2012 (137)
40 GMI ss287386127 Apr 25, 2013 (138)
41 PJP ss292181892 May 09, 2011 (134)
42 NHLBI-ESP ss342501171 May 09, 2011 (134)
43 PAGE_STUDY ss469415197 May 04, 2012 (137)
44 ILLUMINA ss483790081 May 04, 2012 (137)
45 ILLUMINA ss483831840 May 04, 2012 (137)
46 1000GENOMES ss491160855 May 04, 2012 (137)
47 EXOME_CHIP ss491548762 May 04, 2012 (137)
48 CLINSEQ_SNP ss491769032 May 04, 2012 (137)
49 ILLUMINA ss535988448 Sep 08, 2015 (146)
50 TISHKOFF ss566000621 Apr 25, 2013 (138)
51 SSMP ss661867763 Apr 25, 2013 (138)
52 ILLUMINA ss780409387 Aug 21, 2014 (142)
53 ILLUMINA ss780746547 Aug 21, 2014 (142)
54 ILLUMINA ss782338610 Aug 21, 2014 (142)
55 ILLUMINA ss783424285 Aug 21, 2014 (142)
56 ILLUMINA ss835898393 Aug 21, 2014 (142)
57 JMKIDD_LAB ss974506464 Aug 21, 2014 (142)
58 EVA-GONL ss994328876 Aug 21, 2014 (142)
59 JMKIDD_LAB ss1067590310 Aug 21, 2014 (142)
60 JMKIDD_LAB ss1081922932 Aug 21, 2014 (142)
61 1000GENOMES ss1363287672 Aug 21, 2014 (142)
62 DDI ss1428410471 Apr 01, 2015 (144)
63 EVA_GENOME_DK ss1578649466 Apr 01, 2015 (144)
64 EVA_FINRISK ss1584118074 Apr 01, 2015 (144)
65 EVA_UK10K_ALSPAC ss1638023868 Apr 01, 2015 (144)
66 EVA_UK10K_TWINSUK ss1681017901 Apr 01, 2015 (144)
67 EVA_EXAC ss1693649141 Apr 01, 2015 (144)
68 EVA_MGP ss1711516489 Apr 01, 2015 (144)
69 EVA_SVP ss1713664102 Apr 01, 2015 (144)
70 ILLUMINA ss1752287019 Sep 08, 2015 (146)
71 HAMMER_LAB ss1809320826 Sep 08, 2015 (146)
72 ILLUMINA ss1917938326 Feb 12, 2016 (147)
73 WEILL_CORNELL_DGM ss1937824539 Feb 12, 2016 (147)
74 ILLUMINA ss1946536793 Feb 12, 2016 (147)
75 ILLUMINA ss1959867559 Feb 12, 2016 (147)
76 GENOMED ss1968648432 Jul 19, 2016 (147)
77 JJLAB ss2029689933 Sep 14, 2016 (149)
78 USC_VALOUEV ss2158231659 Dec 20, 2016 (150)
79 HUMAN_LONGEVITY ss2225938826 Dec 20, 2016 (150)
80 TOPMED ss2391738938 Dec 20, 2016 (150)
81 SYSTEMSBIOZJU ss2629341305 Nov 08, 2017 (151)
82 ILLUMINA ss2633542689 Nov 08, 2017 (151)
83 ILLUMINA ss2635083761 Nov 08, 2017 (151)
84 GRF ss2702844270 Nov 08, 2017 (151)
85 GNOMAD ss2744065581 Nov 08, 2017 (151)
86 GNOMAD ss2750210839 Nov 08, 2017 (151)
87 GNOMAD ss2963218761 Nov 08, 2017 (151)
88 AFFY ss2985143632 Nov 08, 2017 (151)
89 AFFY ss2985775439 Nov 08, 2017 (151)
90 SWEGEN ss3017523532 Nov 08, 2017 (151)
91 EVA_SAMSUNG_MC ss3023072222 Nov 08, 2017 (151)
92 BIOINF_KMB_FNS_UNIBA ss3028674987 Nov 08, 2017 (151)
93 TOPMED ss3294083008 Nov 08, 2017 (151)
94 CSHL ss3352315313 Nov 08, 2017 (151)
95 ILLUMINA ss3627938438 Oct 12, 2018 (152)
96 ILLUMINA ss3627938439 Oct 12, 2018 (152)
97 ILLUMINA ss3631513796 Oct 12, 2018 (152)
98 ILLUMINA ss3634737052 Oct 12, 2018 (152)
99 ILLUMINA ss3638229063 Oct 12, 2018 (152)
100 ILLUMINA ss3640444360 Oct 12, 2018 (152)
101 ILLUMINA ss3642061482 Oct 12, 2018 (152)
102 ILLUMINA ss3643201732 Oct 12, 2018 (152)
103 ILLUMINA ss3644725307 Oct 12, 2018 (152)
104 OMUKHERJEE_ADBS ss3646537915 Oct 12, 2018 (152)
105 URBANLAB ss3650923072 Oct 12, 2018 (152)
106 ILLUMINA ss3653916316 Oct 12, 2018 (152)
107 EGCUT_WGS ss3684271980 Jul 13, 2019 (153)
108 EVA_DECODE ss3702825211 Jul 13, 2019 (153)
109 ACPOP ss3743063341 Jul 13, 2019 (153)
110 ILLUMINA ss3744465498 Jul 13, 2019 (153)
111 ILLUMINA ss3745037062 Jul 13, 2019 (153)
112 EVA ss3756100044 Jul 13, 2019 (153)
113 PAGE_CC ss3772015558 Jul 13, 2019 (153)
114 ILLUMINA ss3772534169 Jul 13, 2019 (153)
115 PACBIO ss3788538039 Jul 13, 2019 (153)
116 PACBIO ss3793446839 Jul 13, 2019 (153)
117 PACBIO ss3798333709 Jul 13, 2019 (153)
118 KHV_HUMAN_GENOMES ss3821348043 Jul 13, 2019 (153)
119 EVA ss3825297801 Apr 27, 2020 (154)
120 EVA ss3825532995 Apr 27, 2020 (154)
121 EVA ss3825547443 Apr 27, 2020 (154)
122 EVA ss3825937631 Apr 27, 2020 (154)
123 EVA ss3835475545 Apr 27, 2020 (154)
124 EVA ss3841360322 Apr 27, 2020 (154)
125 EVA ss3846866422 Apr 27, 2020 (154)
126 SGDP_PRJ ss3888283704 Apr 27, 2020 (154)
127 KRGDB ss3938407459 Apr 27, 2020 (154)
128 KOGIC ss3981414458 Apr 27, 2020 (154)
129 FSA-LAB ss3984156048 Apr 26, 2021 (155)
130 EVA ss3984742526 Apr 26, 2021 (155)
131 EVA ss3986081067 Apr 26, 2021 (155)
132 EVA ss3986800845 Apr 26, 2021 (155)
133 EVA ss4017826174 Apr 26, 2021 (155)
134 TOPMED ss5075843346 Apr 26, 2021 (155)
135 TOMMO_GENOMICS ss5227904400 Apr 26, 2021 (155)
136 EVA ss5236962280 Apr 26, 2021 (155)
137 EVA ss5237247793 Apr 26, 2021 (155)
138 1000Genomes NC_000019.9 - 44055726 Oct 12, 2018 (152)
139 The Avon Longitudinal Study of Parents and Children NC_000019.9 - 44055726 Oct 12, 2018 (152)
140 Genetic variation in the Estonian population NC_000019.9 - 44055726 Oct 12, 2018 (152)
141 ExAC NC_000019.9 - 44055726 Oct 12, 2018 (152)
142 FINRISK NC_000019.9 - 44055726 Apr 27, 2020 (154)
143 The Danish reference pan genome NC_000019.9 - 44055726 Apr 27, 2020 (154)
144 gnomAD - Genomes NC_000019.10 - 43551574 Apr 26, 2021 (155)
145 gnomAD - Exomes NC_000019.9 - 44055726 Jul 13, 2019 (153)
146 GO Exome Sequencing Project NC_000019.9 - 44055726 Oct 12, 2018 (152)
147 Genome of the Netherlands Release 5 NC_000019.9 - 44055726 Apr 27, 2020 (154)
148 HapMap NC_000019.10 - 43551574 Apr 27, 2020 (154)
149 KOREAN population from KRGDB NC_000019.9 - 44055726 Apr 27, 2020 (154)
150 Korean Genome Project NC_000019.10 - 43551574 Apr 27, 2020 (154)
151 Medical Genome Project healthy controls from Spanish population NC_000019.9 - 44055726 Apr 27, 2020 (154)
152 Northern Sweden NC_000019.9 - 44055726 Jul 13, 2019 (153)
153 The PAGE Study NC_000019.10 - 43551574 Jul 13, 2019 (153)
154 CNV burdens in cranial meningiomas NC_000019.9 - 44055726 Apr 26, 2021 (155)
155 Qatari NC_000019.9 - 44055726 Apr 27, 2020 (154)
156 SGDP_PRJ NC_000019.9 - 44055726 Apr 27, 2020 (154)
157 Siberian NC_000019.9 - 44055726 Apr 27, 2020 (154)
158 8.3KJPN NC_000019.9 - 44055726 Apr 26, 2021 (155)
159 TopMed NC_000019.10 - 43551574 Apr 26, 2021 (155)
160 UK 10K study - Twins NC_000019.9 - 44055726 Oct 12, 2018 (152)
161 A Vietnamese Genetic Variation Database NC_000019.9 - 44055726 Jul 13, 2019 (153)
162 ALFA NC_000019.10 - 43551574 Apr 26, 2021 (155)
163 ClinVar RCV000660796.1 Oct 12, 2018 (152)
164 ClinVar RCV000660797.1 Oct 12, 2018 (152)
165 ClinVar RCV000660798.1 Oct 12, 2018 (152)
166 ClinVar RCV000660799.1 Oct 12, 2018 (152)
167 ClinVar RCV000660800.1 Oct 12, 2018 (152)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs3817410 Oct 08, 2002 (108)
rs11553658 May 23, 2008 (130)
rs17435395 May 23, 2008 (130)
rs57378728 May 23, 2008 (130)
rs386493716 Aug 21, 2014 (142)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss81579111, ss82161334, ss84461363, ss90981936, ss111404487, ss115168764, ss117713217, ss168227465, ss169801689, ss203762255, ss208533173, ss244291045, ss255689616, ss283219242, ss287386127, ss292181892, ss483831840, ss491769032, ss1713664102, ss2635083761, ss3643201732 NC_000019.8:48747565:T:C NC_000019.10:43551573:T:C (self)
76698528, 42471571, 30010228, 4156527, 114535, 4831531, 13380543, 1754760, 18920788, 45584853, 632249, 16348206, 292083, 19866461, 40300684, 10748013, 85873707, 42471571, 9378985, ss228151066, ss237685541, ss243889121, ss342501171, ss483790081, ss491160855, ss491548762, ss535988448, ss566000621, ss661867763, ss780409387, ss780746547, ss782338610, ss783424285, ss835898393, ss974506464, ss994328876, ss1067590310, ss1081922932, ss1363287672, ss1428410471, ss1578649466, ss1584118074, ss1638023868, ss1681017901, ss1693649141, ss1711516489, ss1752287019, ss1809320826, ss1917938326, ss1937824539, ss1946536793, ss1959867559, ss1968648432, ss2029689933, ss2158231659, ss2391738938, ss2629341305, ss2633542689, ss2702844270, ss2744065581, ss2750210839, ss2963218761, ss2985143632, ss2985775439, ss3017523532, ss3023072222, ss3352315313, ss3627938438, ss3627938439, ss3631513796, ss3634737052, ss3638229063, ss3640444360, ss3642061482, ss3644725307, ss3646537915, ss3653916316, ss3684271980, ss3743063341, ss3744465498, ss3745037062, ss3756100044, ss3772534169, ss3788538039, ss3793446839, ss3798333709, ss3825297801, ss3825532995, ss3825547443, ss3825937631, ss3835475545, ss3841360322, ss3888283704, ss3938407459, ss3984156048, ss3984742526, ss3986081067, ss3986800845, ss4017826174, ss5227904400 NC_000019.9:44055725:T:C NC_000019.10:43551573:T:C (self)
RCV000660796.1, RCV000660797.1, RCV000660798.1, RCV000660799.1, RCV000660800.1, 540917282, 1699769, 37792459, 1237027, 181776916, 291389010, 7926396280, ss2225938826, ss3028674987, ss3294083008, ss3650923072, ss3702825211, ss3772015558, ss3821348043, ss3846866422, ss3981414458, ss5075843346, ss5236962280, ss5237247793 NC_000019.10:43551573:T:C NC_000019.10:43551573:T:C (self)
ss12469368, ss14722093, ss21536778, ss76892866 NT_011109.15:16323943:T:C NC_000019.10:43551573:T:C (self)
ss28206, ss3254965, ss3655942, ss4473996, ss5003825, ss5586970, ss48405013, ss74891848, ss76863650, ss86342741, ss96268642, ss106056339, ss119339873, ss136259212, ss137687943, ss155923758, ss159740042, ss173387757, ss469415197 NT_011109.16:16323943:T:C NC_000019.10:43551573:T:C (self)
45584853, ss3938407459 NC_000019.9:44055725:T:G NC_000019.10:43551573:T:G (self)
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Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

295 citations for rs25487
PMID Title Author Year Journal
16465622 Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. Wu X et al. 2006 American journal of human genetics
16857995 Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes. Hill DA et al. 2006 Blood
16875718 XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer. Chung HH et al. 2006 Gynecologic oncology
16931584 Multiplex pyrosequencing of two polymorphisms in DNA repair gene XRCC1. van der Straaten T et al. 2006 The Journal of molecular diagnostics
17267408 Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells. Milani L et al. 2007 Nucleic acids research
17425776 DNA repair gene XRCC1 polymorphisms and bladder cancer risk. Sak SC et al. 2007 BMC genetics
17705814 Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain. López-Cima MF et al. 2007 BMC cancer
17767850 [Family-based association study of XRCC1 gene polymorphisms in nasopharyngeal carcinoma]. Pan QH et al. 2007 Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
17984110 Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China. Huang WY et al. 2008 Carcinogenesis
18188695 Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus. Loizidou MA et al. 2008 Breast cancer research and treatment
18191955 Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools. Zhu Y et al. 2008 Mutation research
18214807 Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery. Kim YJ et al. 2008 Journal of toxicology and environmental health. Part A
18298806 Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years. Rosenberger A et al. 2008 BMC cancer
18544627 Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. McWilliams RR et al. 2008 Cancer research
18547414 Genotyping panel for assessing response to cancer chemotherapy. Dai Z et al. 2008 BMC medical genomics
18669164 Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case-control study in North Indian women. Mitra AK et al. 2008 Oncology research
18701435 Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Smith TR et al. 2008 Carcinogenesis
18765826 Genetic variants associated with carboplatin-induced cytotoxicity in cell lines derived from Africans. Huang RS et al. 2008 Molecular cancer therapeutics
18823566 Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population. Kasahara M et al. 2008 Journal of experimental & clinical cancer research
18830263 Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma. Wang SS et al. 2009 Leukemia
18936436 Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Chang MH et al. 2009 American journal of epidemiology
18990748 International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. Hung RJ et al. 2008 Cancer epidemiology, biomarkers & prevention
19029194 Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans. Chang JS et al. 2009 Carcinogenesis
19098027 SNPnexus: a web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms. Chelala C et al. 2009 Bioinformatics (Oxford, England)
19109789 Single nucleotide polymorphisms in DNA repair genes and prostate cancer risk. Park JY et al. 2009 Methods in molecular biology (Clifton, N.J.)
19124499 Association and interactions between DNA repair gene polymorphisms and adult glioma. Liu Y et al. 2009 Cancer epidemiology, biomarkers & prevention
19174490 Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Cote ML et al. 2009 Carcinogenesis
19230024 Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma. Applebaum KM et al. 2009 International journal of cancer
19266243 Single-nucleotide polymorphisms of DNA repair genes OGG1 and XRCC1: association with gallbladder cancer in North Indian population. Srivastava A et al. 2009 Annals of surgical oncology
19274602 Gene-environment interactions between DNA repair polymorphisms and exposure to the carcinogen vinyl chloride. Li Y et al. 2009 Biomarkers
19318434 Associations between polymorphisms in DNA repair genes and glioblastoma. McKean-Cowdin R et al. 2009 Cancer epidemiology, biomarkers & prevention
19362955 DNA repair gene polymorphisms predict favorable clinical outcome in advanced non-small-cell lung cancer. Kalikaki A et al. 2009 Clinical lung cancer
19367277 Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer. Chang-Claude J et al. 2009 British journal of cancer
19484764 DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic lymphocytic leukemia. Ganster C et al. 2009 Genes, chromosomes & cancer
19536092 Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. Kweekel DM et al. 2009 British journal of cancer
19604089 Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan. Hoskins JM et al. 2009 Pharmacogenomics
19706757 Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. Stern MC et al. 2009 Cancer research
19707910 Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis. Coppedè F et al. 2010 Amyotrophic lateral sclerosis
19786980 Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients. Khrunin AV et al. 2010 The pharmacogenomics journal
19826048 Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. Akbari MR et al. 2009 Cancer research
19880550 Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population. Lin YJ et al. 2009 Lupus
19902366 Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. Agalliu I et al. 2010 Cancer causes & control
20003463 Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma. Yin Z et al. 2009 BMC cancer
20066159 MMP9 but Not EGFR, MET, ERCC1, P16, and P-53 Is Associated with Response to Concomitant Radiotherapy, Cetuximab, and Weekly Cisplatin in Patients with Locally Advanced Head and Neck Cancer. Fountzilas G et al. 2009 Journal of oncology
20150366 DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Rajaraman P et al. 2010 Neuro-oncology
20211558 Genetic advances in glioma: susceptibility genes and networks. Liu Y et al. 2010 Current opinion in genetics & development
20226869 Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations. Thyagarajan B et al. 2010 Biology of blood and marrow transplantation
20334523 Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes. Alsbeih G et al. 2010 Radiation research
20439344 Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients. Sun Z et al. 2010 Annals of oncology
20442803 XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: A family-based case-control study. Zipprich J et al. 2010 Journal of carcinogenesis
20477822 Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer. Abe M et al. 2011 BJU international
20559012 Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study. Stern MC et al. 2009 Journal of nutrigenetics and nutrigenomics
20577654 XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. Chen PL et al. 2010 Molecular vision
20602618 Irinotecan pharmacogenomics. Marsh S et al. 2010 Pharmacogenomics
20719408 No association between DNA repair gene XRCC1 and amyotrophic lateral sclerosis. Fang F et al. 2012 Neurobiology of aging
20847277 Genotyping of DNA samples isolated from formalin-fixed paraffin-embedded tissues using preamplification. Baak-Pablo R et al. 2010 The Journal of molecular diagnostics
20863523 XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer. Grimminger PP et al. 2010 The Journal of surgical research
20935060 Genetic modifiers of carcinogen DNA adducts in target lung and peripheral blood mononuclear cells. Lee MS et al. 2010 Carcinogenesis
20935063 Smoking and selected DNA repair gene polymorphisms in controls: systematic review and meta-analysis. Hodgson ME et al. 2010 Cancer epidemiology, biomarkers & prevention
20957144 Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. Ji G et al. 2010 PloS one
21037106 Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. Brevik A et al. 2010 Cancer epidemiology, biomarkers & prevention
21057378 Multiple genetic polymorphisms in the prediction of clinical outcome of metastatic colorectal cancer patients treated with first-line FOLFOX-4 chemotherapy. Huang MY et al. 2011 Pharmacogenetics and genomics
21183201 DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 loci in Maharashtrian population of central India. Pramanik S et al. 2011 Chemosphere
21195504 Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Qian B et al. 2011 Lung cancer (Amsterdam, Netherlands)
21283657 Gallbladder cancer predisposition: a multigenic approach to DNA-repair, apoptotic and inflammatory pathway genes. Srivastava K et al. 2011 PloS one
21364592 CYP2A6 and ERCC1 polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients. Park SR et al. 2011 British journal of cancer
21419115 DNA repair gene ERCC2 polymorphisms and risk of squamous cell carcinoma of the head and neck. Gugatschka M et al. 2011 Experimental and molecular pathology
21420246 Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. Yin M et al. 2011 International journal of radiation oncology, biology, physics
21423097 Polymorphisms of the DNA repair genes XRCC1 and ERCC4 are not associated with smoking- and drinking-dependent larynx cancer in a Polish population. Krupa R et al. 2011 Experimental oncology
21427728 Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2. Osorio A et al. 2011 British journal of cancer
21463129 An XRCC1 polymorphism is associated with the outcome of patients with lymphoma undergoing autologous stem cell transplant. Guillem VM et al. 2011 Leukemia & lymphoma
21514219 Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Zhang B et al. 2011 The Lancet. Oncology
21561390 Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population. Canbay E et al. 2011 Current medical research and opinion
21586140 Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group. Yoon HH et al. 2011 BMC cancer
21612998 No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk. Gsur A et al. 2011 Cancer epidemiology
21617750 XRCC1 and XPD DNA repair gene polymorphisms: a potential risk factor for glaucoma in the Pakistani population. Yousaf S et al. 2011 Molecular vision
21622940 Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study. Roberts MR et al. 2011 Carcinogenesis
21682595 XRCC1 Arg399Gln gene polymorphism and the risk of systemic lupus erythematosus in the Polish population. Warchoł T et al. 2012 DNA and cell biology
21700777 Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer. Smith TR et al. 2011 Carcinogenesis
21708280 Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis. Srivastava K et al. 2011 Mutation research
21739480 Potentially functional polymorphisms in DNA repair genes and non-small-cell lung cancer survival: a pathway-based analysis. Dong J et al. 2012 Molecular carcinogenesis
21741876 Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk. Anantharaman D et al. 2011 Oral oncology
21749698 Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of articledeveloping erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery. Falvo E et al. 2011 BMC cancer
21810555 Genetic variation in base excision repair pathway genes, pesticide exposure, and prostate cancer risk. Barry KH et al. 2011 Environmental health perspectives
21846818 Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality. Lin DW et al. 2011 Cancer epidemiology, biomarkers & prevention
21877955 Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia. Al-Hadyan KS et al. 2012 Genetic testing and molecular biomarkers
21915362 Sequence variants in antioxidant defense and DNA repair genes, dietary antioxidants, and pancreatic cancer risk. Zhang J et al. 2011 International journal of molecular epidemiology and genetics
21974800 DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome. Reeves SG et al. 2012 Cancer epidemiology
21976407 Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer. Buch SC et al. 2012 Molecular carcinogenesis
21987112 Association of Arg194Trp, Arg280His and Arg399Gln polymorphisms in X-ray repair cross-complementing group 1 gene and risk of differentiated thyroid carcinoma in Iran. Fard-Esfahani P et al. 2011 Iranian biomedical journal
22026922 Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy. Giovannetti E et al. 2011 Pharmacogenomics
22076708 Validation of genetic sequence variants as prognostic factors in early-stage head and neck squamous cell cancer survival. Azad AK et al. 2012 Clinical cancer research
22125427 An overview of DNA repair in amyotrophic lateral sclerosis. Coppedè F et al. 2011 TheScientificWorldJournal
22186158 Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan. Yin G et al. 2012 Journal of epidemiology
22188361 Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins. Khrunin A et al. 2012 Pharmacogenomics
22215955 Polymorphisms associated with the risk of lung cancer in a healthy Mexican Mestizo population: Application of the additive model for cancer. Pérez-Morales R et al. 2011 Genetics and molecular biology
22272830 SNPs in DNA repair or oxidative stress genes and late subcutaneous fibrosis in patients following single shot partial breast irradiation. Falvo E et al. 2012 Journal of experimental & clinical cancer research
22281126 The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1. Hanssen-Bauer A et al. 2012 DNA repair
22339849 Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis. Cui Z et al. 2012 BMC cancer
22525558 Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population. Kiyohara C et al. 2012 Journal of thoracic oncology
22529951 X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and risk of childhood acute lymphoblastic leukemia: a meta-analysis. Wang L et al. 2012 PloS one
22537351 Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy. Raabe A et al. 2012 Radiation oncology (London, England)
22655231 Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium. Chuang SC et al. 2011 Frontiers in oncology
22659345 Polymorphisms of DNA repair genes in Korean hepatocellular carcinoma patients with chronic hepatitis B: possible implications on survival. Jung SW et al. 2012 Journal of hepatology
22687647 Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population. Santonocito C et al. 2012 Clinica chimica acta; international journal of clinical chemistry
22740911 Single nucleotide polymorphisms in DNA repair genes and risk of cervical cancer: A case-control study. Zhang L et al. 2012 Oncology letters
22761669 Meta-analysis on pharmacogenetics of platinum-based chemotherapy in non small cell lung cancer (NSCLC) patients. Yin JY et al. 2012 PloS one
22792228 Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes. Yu H et al. 2012 PloS one
22850545 Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese. Nakao M et al. 2012 Journal of epidemiology
22927776 Interaction between polymorphisms of DNA repair genes significantly modulated bladder cancer risk. Zhi Y et al. 2012 International journal of medical sciences
22969958 Genetic polymorphisms in key DNA repair genes and risk of head and neck cancer in a Chinese population. Yuan H et al. 2012 Experimental and therapeutic medicine
22984511 X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: a huge systematic review and meta-analysis. Li Y et al. 2012 PloS one
22992668 Pharmacogenomics knowledge for personalized medicine. Whirl-Carrillo M et al. 2012 Clinical pharmacology and therapeutics
23202958 Genetic variability in DNA repair proteins in age-related macular degeneration. Blasiak J et al. 2012 International journal of molecular sciences
23226053 ERCC1 and XRCC1 as biomarkers for lung and head and neck cancer. Vaezi A et al. 2011 Pharmacogenomics and personalized medicine
23247283 X-ray repair cross complementing protein 1 in base excision repair. Hanssen-Bauer A et al. 2012 International journal of molecular sciences
23271134 Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case-control studies. Liu L et al. 2013 Molecular biology reports
23313170 Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin. Kelsey CR et al. 2013 Clinical lung cancer
23443124 XRCC3 gene polymorphism is associated with survival in Japanese lung cancer patients. Osawa K et al. 2012 International journal of molecular sciences
23554684 Genetic susceptibility of cervical cancer. Chen X et al. 2011 Journal of biomedical research
23565320 DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial. Doherty JA et al. 2013 International journal of molecular epidemiology and genetics
23684781 Phase II study of satraplatin and prednisone in patients with metastatic castration-resistant prostate cancer: a pharmacogenetic assessment of outcome and toxicity. Figg WD et al. 2013 Clinical genitourinary cancer
23697595 SNPs in genes implicated in radiation response are associated with radiotoxicity and evoke roles as predictive and prognostic biomarkers. Alsbeih G et al. 2013 Radiation oncology (London, England)
23719583 Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer. Kerns SL et al. 2013 Radiotherapy and oncology
23720673 Molecular epidemiology of DNA repair gene polymorphisms and head and neck cancer. Wang M et al. 2013 Journal of biomedical research
23892592 Association of genetic variants in CDK6 and XRCC1 with the risk of dysplastic nevi in melanoma-prone families. Liang X et al. 2014 The Journal of investigative dermatology
23946381 Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Ma X et al. 2014 Gut
23973201 Polymorphisms in DNA repair and apoptosis-related genes and clinical outcomes of patients with non-small cell lung cancer treated with first-line paclitaxel-cisplatin chemotherapy. Lee SY et al. 2013 Lung cancer (Amsterdam, Netherlands)
24057881 XRCC1 polymorphisms and cervical cancer risk: an updated meta-analysis. Mei J et al. 2014 Tumour biology
24084248 The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes. Molina E et al. 2013 Mutation research. Genetic toxicology and environmental mutagenesis
24103542 High-throughput genotyping system as a robust and useful tool in oncology: experience from a single institution. Henríquez-Hernández LA et al. 2013 Biologicals
24172093 Polymorphisms in base excision repair genes are associated with endometrial cancer risk among postmenopausal Japanese women. Hosono S et al. 2013 International journal of gynecological cancer
24177223 Significant interactions between maternal PAH exposure and haplotypes in candidate genes on B[a]P-DNA adducts in a NYC cohort of non-smoking African-American and Dominican mothers and newborns. Iyer S et al. 2014 Carcinogenesis
24224851 X-ray repair cross-complementing 1 polymorphism and prognosis of platinum-based chemotherapy in gastric and colorectal cancer: a meta-analysis. Wu H et al. 2014 Journal of gastroenterology and hepatology
24315498 Synergistic association of DNA repair relevant gene polymorphisms with the risk of coronary artery disease in northeastern Han Chinese. Yu X et al. 2014 Thrombosis research
24325908 Analysis of DNA repair gene polymorphisms in glioblastoma. Rodriguez-Hernandez I et al. 2014 Gene
24340057 Genetic variations in radiation and chemotherapy drug action pathways and survival in locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy. Liu H et al. 2013 PloS one
24446315 Pharmacogenetics of DNA repair gene polymorphisms in non-small-cell lung carcinoma patients on platinum-based chemotherapy. Zhang L et al. 2014 Genetics and molecular research
24500421 Association between DNA repair gene polymorphisms and risk of glioma: a systematic review and meta-analysis. Adel Fahmideh M et al. 2014 Neuro-oncology
24619222 Polymorphisms in DNA repair genes (APEX1, XPD, XRCC1 and XRCC3) and risk of preeclampsia in a Mexican mestizo population. Sandoval-Carrillo A et al. 2014 International journal of molecular sciences
24642895 The relationship between seven common polymorphisms from five DNA repair genes and the risk for breast cancer in northern Chinese women. Ding P et al. 2014 PloS one
24653663 Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations. J de AS et al. 2014 Current genomics
24701578 The role of single nucleotide polymorphisms in predicting prostate cancer risk and therapeutic decision making. Van den Broeck T et al. 2014 BioMed research international
24756092 Polymorphisms in DNA repair genes and MDR1 and the risk for non-Hodgkin lymphoma. Kim HN et al. 2014 International journal of molecular sciences
24847383 ERCC1, XRCC1 and GSTP1 Single Nucleotide Polymorphisms and Survival of Patients with Colon Cancer Receiving Oxaliplatin-Based Adjuvant Chemotherapy. Zaanan A et al. 2014 Journal of Cancer
24933103 Associations of polymorphisms in DNA repair genes and MDR1 gene with chemotherapy response and survival of non-small cell lung cancer. Du Y et al. 2014 PloS one
24940494 Association of <i>XRCC1</i> and <i>XRCC3</i> gene haplotypes with the development of radiation-induced fibrosis in patients with nasopharyngeal carcinoma. Cheuk IW et al. 2014 Molecular and clinical oncology
24971336 XRCC1 Arg399Gln and Arg194Trp polymorphisms and risk of systemic lupus erythematosus in an Iranian population: a pilot study. Salimi S et al. 2014 BioMed research international
25024628 APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans. Zhang SH et al. 2014 World journal of gastroenterology
25025378 ERCC1 Cys8092Ala and XRCC1 Arg399Gln polymorphisms predict progression-free survival after curative radiotherapy for nasopharyngeal carcinoma. Jin H et al. 2014 PloS one
25110414 Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years. Panczyk M et al. 2014 World journal of gastroenterology
25132748 FOLFOX/FOLFIRI pharmacogenetics: the call for a personalized approach in colorectal cancer therapy. Mohelnikova-Duchonova B et al. 2014 World journal of gastroenterology
25202399 DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta-analysis. Li W et al. 2014 Oncology letters
25214541 A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage. Findlay JM et al. 2015 Annals of oncology
25231222 Meat-derived carcinogens, genetic susceptibility and colorectal adenoma risk. Ho V et al. 2014 Genes & nutrition
25232828 Thymidylate synthase genotype-directed chemotherapy for patients with gastric and gastroesophageal junction cancers. Goff LW et al. 2014 PloS one
25245010 Association between XRCC1 polymorphisms and glioma risk among Chinese population. Li J et al. 2014 Medical oncology (Northwood, London, England)
25262700 X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism significantly associated with prostate cancer. Chen Y et al. 2015 The International journal of biological markers
25452763 Can pharmacogenetics explain efficacy and safety of cisplatin pharmacotherapy? Roco A et al. 2014 Frontiers in genetics
25493225 Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity. Patrono C et al. 2014 World journal of clinical oncology
25529925 Do genetic defects of DNA repair relevant proteins alter susceptibility to hypertension? A case-control study in northeastern Han Chinese. Jia N et al. 2015 Clinica chimica acta; international journal of clinical chemistry
25537147 Polymorphisms in DNA repair genes and breast cancer risk in Russian population: a case-control study. Shadrina AS et al. 2016 Clinical and experimental medicine
25541996 Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study. Liu J et al. 2014 PloS one
25563194 XRCC1 genetic polymorphism acts a potential biomarker for lung cancer. Zhu DQ et al. 2015 Tumour biology
25719551 The role of genotypes that modify the toxicity of chemical mutagens in the risk for myeloproliferative neoplasms. Gross-Davis CA et al. 2015 International journal of environmental research and public health
25765877 Platinum-induced neurotoxicity and preventive strategies: past, present, and future. Avan A et al. 2015 The oncologist
25881102 Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer. Lambrechts S et al. 2015 BMC pharmacology & toxicology
25961110 DNA repair genes XRCC1 and ERCC1 polymorphisms and the risk of sporadic breast cancer in Han women in the Gansu Province of China. Zhu G et al. 2015 Genetic testing and molecular biomarkers
26130668 Nucleotide Excision Repair Gene ERCC2 and ERCC5 Variants Increase Risk of Uterine Cervical Cancer. Joo J et al. 2016 Cancer research and treatment
26159902 DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival. Su Y et al. 2015 Cellular physiology and biochemistry
26263974 Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine. Simeon V et al. 2015 International journal of molecular sciences
26314858 Influences of ERCC1, ERCC2, XRCC1, GSTP1, GSTT1, and MTHFR polymorphisms on clinical outcomes in gastric cancer patients treated with EOF chemotherapy. Liu R et al. 2016 Tumour biology
26345972 Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer. Liu JY et al. 2015 Genetics and molecular research
26379967 Association between polymorphisms in APE1 and XRCC1 and the risk of gastric cancer in Korean population. Jin EH et al. 2015 International journal of clinical and experimental medicine
26445852 Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis. Findlay JM et al. 2016 Digestive diseases and sciences
26446325 X-ray repair cross-complementing protein 1 and 3 polymorphisms and susceptibility of breast cancer in a Jordanian population. Al Zoubi MS et al. 2015 Saudi medical journal
26451011 Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas. Montazeri Z et al. 2016 International journal of epidemiology
26475344 CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer. Melchardt T et al. 2015 BMC cancer
26519348 XRCC1 rs25487 genetic variant and TP53 mutation at codon 249 predict clinical outcomes of hepatitis B virus-related hepatocellular carcinoma after hepatectomy: A cohort study for 10 years' follow up. Yu L et al. 2016 Hepatology research
26585370 Predictive assessment in pharmacogenetics of XRCC1 gene on clinical outcomes of advanced lung cancer patients treated with platinum-based chemotherapy. Yuan Z et al. 2015 Scientific reports
26590607 The relationship between five non-synonymous polymorphisms within three XRCC genes and gastric cancer risk in a Han Chinese population. Gong H et al. 2016 Tumour biology
26627042 ERCC2 polymorphisms and radiation-induced adverse effects on normal tissue: systematic review with meta-analysis and trial sequential analysis. Song YZ et al. 2015 Radiation oncology (London, England)
26648684 Update on genetics and diabetic retinopathy. Hampton BM et al. 2015 Clinical ophthalmology (Auckland, N.Z.)
26649138 The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer. Savina NV et al. 2016 Oxidative medicine and cellular longevity
26674097 A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. Seibold P et al. 2015 BMC cancer
26681190 Genetic Polymorphisms in XRCC1, CD3EAP, PPP1R13L, XPB, XPC, and XPF and the Risk of Chronic Benzene Poisoning in a Chinese Occupational Population. Xue P et al. 2015 PloS one
26692147 Association of XRCC1 and OGG1 DNA repair gene polymorphisms with rheumatoid arthritis in Egyptian patients. Mohamed RH et al. 2016 Gene
26824244 DNA Repair Gene (XRCC1) Polymorphism (Arg399Gln) Associated with Schizophrenia in South Indian Population: A Genotypic and Molecular Dynamics Study. Sujitha SP et al. 2016 PloS one
26843108 A Comprehensive Meta-analysis of Genetic Associations Between Key Polymorphic Loci in DNA Repair Genes and Glioma Risk. Qi L et al. 2017 Molecular neurobiology
26869802 Correlation between XRCC1 Arg399Gln genetic polymorphisms and susceptibility to bladder cancer: a meta-analysis. Liu N et al. 2016 OncoTargets and therapy
26870349 Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients. Guo CX et al. 2016 Molecular and clinical oncology
26918371 Roles of XRCC1/XPD/ERCC1 Polymorphisms in Predicting Prognosis of Hepatocellular Carcinoma in Patients Receiving Transcatheter Arterial Chemoembolization. Wang XC et al. 2016 Genetic testing and molecular biomarkers
27053949 Detecting gene-gene interactions using a permutation-based random forest method. Li J et al. 2016 BioData mining
27055523 Polymorphisms in DNA Repair Gene and Susceptibility to Glioma: A Systematic Review and Meta-Analysis Based on 33 Studies with 15 SNPs in 9 Genes. Liu K et al. 2017 Cellular and molecular neurobiology
27153553 Association of nineteen polymorphisms from seven DNA repair genes and the risk for bladder cancer in Gansu province of China. Zhu G et al. 2016 Oncotarget
27246533 The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC. Wang C et al. 2016 Scientific reports
27258253 Targeting DNA Damage Response in the Radio(Chemo)therapy of Non-Small Cell Lung Cancer. Li L et al. 2016 International journal of molecular sciences
27328741 Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients. Dimberg J et al. 2016 APMIS
27372710 Association between polymorphisms in genes related to DNA base-excision repair with risk and prognosis of oropharyngeal squamous cell carcinoma. Costa EF et al. 2016 Journal of cancer research and clinical oncology
27376129 Independent Replication of Published Germline Polymorphisms Associated with Urinary Bladder Cancer Prognosis and Treatment Response. Grotenhuis AJ et al. 2016 Bladder cancer (Amsterdam, Netherlands)
27415837 Cervical Cancer Genetic Susceptibility: A Systematic Review and Meta-Analyses of Recent Evidence. Martínez-Nava GA et al. 2016 PloS one
27462201 From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research. Pagliaroli L et al. 2016 Frontiers in neuroscience
27463724 Genetic Variations in the Promoter of the APE1 Gene Are Associated with DMF-Induced Abnormal Liver Function: A Case-Control Study in a Chinese Population. Tong Z et al. 2016 International journal of environmental research and public health
27465648 The genetic variations in DNA repair genes ERCC2 and XRCC1 were associated with the overall survival of advanced non-small-cell lung cancer patients. Wang S et al. 2016 Cancer medicine
27502069 EGFR and SYNE2 are associated with p21 expression and SYNE2 variants predict post-operative clinical outcomes in HBV-related hepatocellular carcinoma. Han C et al. 2016 Scientific reports
27536357 Genetic susceptibility to Barrett's oesophagus: Lessons from early studies. Findlay JM et al. 2016 United European gastroenterology journal
27588484 Gene-gene interactions in gastrointestinal cancer susceptibility. Kim J et al. 2016 Oncotarget
27608007 Pharmacogenetics Biomarkers and Their Specific Role in Neoadjuvant Chemoradiotherapy Treatments: An Exploratory Study on Rectal Cancer Patients. Dreussi E et al. 2016 International journal of molecular sciences
27618021 Pharmacogenomics in Pediatric Oncology: Review of Gene-Drug Associations for Clinical Use. Mlakar V et al. 2016 International journal of molecular sciences
27668351 Study of association between pre-senile cataracts and rs11615 of ERCC1, rs13181 of ERCC2, and rs25487 of XRCC1 polymorphisms in a Spanish population. López-Valverde G et al. 2017 Ophthalmic genetics
27688118 Single nucleotide polymorphisms as markers of genetic susceptibility for oral potentially malignant disorders risk: Review of evidence to date. Shridhar K et al. 2016 Oral oncology
27754415 Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer. Verde Z et al. 2016 International journal of molecular sciences
27763529 Polymorphism of the XRCC1 Gene Is Associated with Susceptibility and Short-Term Recovery of Ischemic Stroke. He W et al. 2016 International journal of environmental research and public health
27838878 Gene-environment interactions between ERCC2, ERCC3, XRCC1 and cadmium exposure in nasal polyposis disease. Khlifi R et al. 2017 Journal of applied genetics
27866211 Single-Nucleotide Polymorphisms of Genes Involved in Repair of Oxidative DNA Damage and the Risk of Recurrent Depressive Disorder. Czarny P et al. 2016 Medical science monitor
27895494 <i>ERCC1</i> and <i>XRCC1</i> but not <i>XPA</i> single nucleotide polymorphisms correlate with response to chemotherapy in endometrial carcinoma. Chen L et al. 2016 OncoTargets and therapy
28058700 XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Italian population. Santonocito C et al. 2017 The International journal of biological markers
28240845 Genetic Association of XRCC1 Gene rs1799782, rs25487 and rs25489 Polymorphisms with Risk of Thyroid Cancer: a Systematic Review and Meta-Analysis Jafari Nedooshan J et al. 2017 Asian Pacific journal of cancer prevention
28253266 Association of OGG1 and MTHFR polymorphisms with age-related cataract: A systematic review and meta-analysis. Wu X et al. 2017 PloS one
28324443 Among 45 variants in 11 genes, HDM2 promoter polymorphisms emerge as new candidate biomarker associated with radiation toxicity. Alsbeih G et al. 2014 3 Biotech
28330811 Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis. Zhang M et al. 2017 EBioMedicine
28351583 Candidate apoptotic and DNA repair gene approach confirms involvement of ERCC1, ERCC5, TP53 and MDM2 in radiation-induced toxicity in head and neck cancer. Borchiellini D et al. 2017 Oral oncology
28405167 Genetic variants and increased risk of meningioma: an updated meta-analysis. Han XY et al. 2017 OncoTargets and therapy
28415705 Meta-analysis of XRCC1 polymorphism and risk of female reproductive system cancer. Yang NN et al. 2017 Oncotarget
28422153 Clinical-pharmacogenetic models for personalized cancer treatment: application to malignant mesothelioma. Goričar K et al. 2017 Scientific reports
28499365 Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation. Lonjou C et al. 2017 BMC cancer
28520216 Evaluation of Prediction of Polymorphisms of DNA Repair Genes on the Efficacy of Platinum-Based Chemotherapy in Patients With Non-Small Cell Lung Cancer: A Network Meta-Analysis. Yu SN et al. 2017 Journal of cellular biochemistry
28652652 Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update. Sharma A et al. 2017 World journal of gastroenterology
28749186 Correlation between CAT polymorphism and susceptibility to DMAc-induced abnormal liver function: a case-control study of Chinese population. Song X et al. 2018 Biomarkers
28803404 Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population. Feki-Tounsi M et al. 2017 Environmental science and pollution research international
28827732 Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies. Wang J et al. 2017 Scientific reports
28880740 Cytogenetic monitoring of hospital staff exposed to ionizing radiation: optimize protocol considering DNA repair genes variability. Doukali H et al. 2017 International journal of radiation biology
28965273 Association of Glutathione S-Transferase P-1 (GSTP-1) rs1695 polymorphism with overall survival in glioblastoma patients treated with combined radio-chemotherapy. Pasqualetti F et al. 2018 Investigational new drugs
28983784 Genetic Variations of DNA Repair Genes in Breast Cancer. Özgöz A et al. 2019 Pathology oncology research
29035403 [Polymorphism of genes encoding proteins of DNA repair vs. occupational and environmental exposure to lead, arsenic and pesticides]. Bukowski K et al. 2018 Medycyna pracy
29110586 Genetic variants of SULT1A1 and XRCC1 genes and risk of lung cancer in Bangladeshi population. Tasnim T et al. 2017 Tumour biology
29139108 A 3' untranslated region polymorphism rs2304277 in the DNA repair pathway gene OGG1 is a novel risk modulator for urothelial bladder carcinoma. Ahmed T et al. 2018 Annals of human genetics
29193749 Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years. Borobia AM et al. 2018 Clinical and translational science
29209986 Data on Single Nucleotide Polymorphism of DNA Repair Genes and Breast Cancer Risk from Poland. Smolarz B et al. 2019 Pathology oncology research
29285737 Association between Polymorphisms of X-Ray Repair Cross Complementing Group 1 Gene and Pancreatic Cancer Risk: a Systematic Review with Meta-Analysis. Chen J et al. 2019 Pathology oncology research
29416669 Association of DNA repair gene polymorphisms with the risk of radiation pneumonitis in lung cancer patients. Du L et al. 2018 Oncotarget
29552790 Haplotype analysis of XRCC1 gene polymorphisms and the risk of thyroid carcinoma. Bashir K et al. 2018 Journal of B.U.ON.
29662106 Pharmacogenetics of platinum-based chemotherapy: impact of DNA repair and folate metabolism gene polymorphisms on prognosis of non-small cell lung cancer patients. Pérez-Ramírez C et al. 2019 The pharmacogenomics journal
29662639 Polymorphisms in BER genes and risk of breast cancer: evidences from 69 studies with 33760 cases and 33252 controls. Qiao L et al. 2018 Oncotarget
29721745 Hemoglobin level and XRCC1 polymorphisms to select patients with locally advanced rectal cancer candidate for neoadjuvant chemoradiotherapy with concurrent capecitabine and a platinum salt. Formica V et al. 2018 Medical oncology (Northwood, London, England)
30013370 Predictive value of single nucleotide polymorphisms in <i>XRCC1</i> for radiation-induced normal tissue toxicity. Zhao J et al. 2018 OncoTargets and therapy
30043545 Impact of polymorphism in DNA repair genes OGG1 and XRCC1 on seminal parameters and human male infertility. Garcia-Rodriguez A et al. 2018 Andrologia
30072825 Genetic Variant Arg399Gln G&gt;A of XRCC1 DNA Repair Gene Enhanced Cancer Risk Among Indian Population: Evidence from Meta-analysis and Trial Sequence Analyses. Mandal RK et al. 2018 Indian journal of clinical biochemistry
30139066 Meta-Analysis of Polymorphic Variants Conferring Genetic Risk to Cervical Cancer in Indian Women Supports CYP1A1 as an Important Associated Locus Sengupta D et al. 2018 Asian Pacific journal of cancer prevention
30194171 Studies of Correlations Between Single Nucleotide Polymorphisms of DNA Repair Genes and Endometrial Cancer in Polish Women. Smolarz B et al. 2018 Anticancer research
30337837 Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis. Wen J et al. 2018 Cancer cell international
30362960 <i>XRCC1</i> gene polymorphisms and risk of neuroblastoma in Chinese children. Zhang J et al. 2018 Aging
30464596 The association of XRCC1 polymorphism with osteosarcoma risk, clinicopathologic features, and prognosis in a Chinese Han population. Wu YG et al. 2018 Cancer management and research
30472145 Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy. Yesil-Devecioglu T et al. 2019 Endocrinologia, diabetes y nutricion
30593754 BER gene polymorphisms associated with key molecular events in bladder cancer. Smal MP et al. 2018 Experimental oncology
30616520 Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study. Liu GC et al. 2019 BMC cancer
30728902 Polymorphism of DNA repair genes in breast cancer. Smolarz B et al. 2019 Oncotarget
30744808 Association of BER and NER pathway polymorphism haplotypes and micronucleus frequencies with global DNA methylation in benzene-exposed workers of China: Effects of DNA repair genes polymorphisms on genetic damage. Zhang GH et al. 2019 Mutation research. Genetic toxicology and environmental mutagenesis
30781715 Genetic Epidemiology of Breast Cancer in Latin America. Zavala VA et al. 2019 Genes
30793520 Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies. Tian J et al. 2019 Cancer medicine
31113197 The polymorphism of XRCC1 Arg399Gln (rs25487) and male infertility risk: a meta-analysis of 1,407 cases and 974 control studies. Ibrahimi R et al. 2019 Bratislavske lekarske listy
31175773 Allelic polymorphisms of dna repair genes and their influence on the formation of resistance to the development of bronchopulmonary pathology under the action of industrial aerosols. Andrushchenko TA et al. 2019 Wiadomosci lekarskie (Warsaw, Poland
31281357 A Comprehensive Evaluation of the Association between Polymorphisms in <i>XRCC1</i>, <i>ERCC2</i>, and <i>XRCC3</i> and Prognosis in Hepatocellular Carcinoma: A Meta-Analysis. Zhao Y et al. 2019 Journal of oncology
31286393 Lack of association between functional polymorphism of DNA repair genes (XRCC1, XPD) and clinical response in Indian chronic myeloid leukemia patients. Dhangar S et al. 2019 Molecular biology reports
31354343 Urinary 8-hydroxydeoxyguanosine in relation to XRCC1 rs25487 G/A (Arg399Gln) and OGG1 rs1052133 C/G (Ser326Cys) DNA repair genes polymorphisms in patients with chronic hepatitis C and related hepatocellular carcinoma. Mahmoud AA et al. 2019 Cancer management and research
31395900 Sex-Related Differences in Impact on Safety of Pharmacogenetic Profile for Colon Cancer Patients Treated with FOLFOX-4 or XELOX Adjuvant Chemotherapy. Ruzzo A et al. 2019 Scientific reports
31446980 Residential radon, genetic polymorphisms in DNA damage and repair-related. Lorenzo-González M et al. 2019 Lung cancer (Amsterdam, Netherlands)
31478326 Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review. Dietrich S et al. 2019 Obesity reviews
31544312 XRCC1-mediated DNA repair is associated with progression-free survival of multiple myeloma patients after autologous stem cell transplant. Persaud AK et al. 2019 Molecular carcinogenesis
31584889 Polymorphisms in DNA repair genes in lung cancer patients living in a coal-mining region. Minina VI et al. 2019 European journal of cancer prevention
31818908 Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer. Montazeri Z et al. 2020 Gut
31821471 Polymorphisms and endometriosis: a systematic review and meta-analyses. Méar L et al. 2020 Human reproduction update
31855267 XRCC1 variants do not represent a risk for dermatomyositis and systemic lupus erythematosus in Bulgarian patients. Kamenarska Z et al. 2019 Acta dermatovenerologica Alpina, Pannonica, et Adriatica
31898659 DNA base excision repair genes variants rs25487 (X-ray repair cross-complementing 1) and rs1052133 (human 8-oxoguanine glycosylase 1) with susceptibility to ovarian cancer in the population of the Jammu region, India. Verma S et al. 2019 Journal of cancer research and therapeutics
31914346 The effects of DNA repair polymorphisms on chromosome aberrations in the population of Kazakhstan. Djansugurova L et al. 2020 International journal of radiation biology
31949858 The association between XRCC1 polymorphism and laryngeal cancer susceptibility in different ethnic groups in Xinjiang, China. Alimu N et al. 2018 International journal of clinical and experimental pathology
32192442 MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia. Floris M et al. 2020 BMC cancer
32265040 Loci associated with genomic damage levels in chronic kidney disease patients and controls. Corredor Z et al. 2020 Mutation research. Genetic toxicology and environmental mutagenesis
32281666 Genetic variations in DNA-repair genes (XRCC1, 3, and 7) and the susceptibility to hepatocellular carcinoma in a cohort of Egyptians. Aboul Enein AA et al. 2020 Journal of medical virology
32397974 Association of DNA repair gene variants with colorectal cancer: risk, toxicity, and survival. Salimzadeh H et al. 2020 BMC cancer
32441565 Efficacy and toxicity of adjuvant chemotherapy on colorectal cancer patients: how much influence from the genetics? Duran G et al. 2020 Journal of chemotherapy (Florence, Italy)
32487623 Induction Chemotherapy in Hypopharyngeal Cancer: Influence of DNA Repair Gene Polymorphisms. Hirakawa H et al. 2020 Anticancer research
32519309 DNA repair genes hOGG1, XRCC1 and ERCC2 polymorphisms and their molecular mapping in breast cancer patients from India. Rajagopal T et al. 2020 Molecular biology reports
32643432 Impact of single nucleotide polymorphisms in the <i>OGG1</i> and <i>XRCC1</i> genes on modulation of DNA damage in pesticide-exposed agricultural workers in Punjab, North-West India. Kaur K et al. 2020 Biomarkers
32684929 Potential Functional Variants in DNA Repair Genes Are Associated with Efficacy and Toxicity of Radiotherapy in Patients with Non-Small-Cell Lung Cancer. Yang Z et al. 2020 Journal of oncology
32711416 Influence of Two DNA Repair Pathway Polymorphisms in Colorectal Cancer Risk in Southwest Iran. Hosseini SM et al. 2020 Asian Pacific journal of cancer prevention
32711417 ERCC1, XRCC1, and GSTP1 Polymorphisms and Treatment Outcomes of Advanced Epithelial Ovarian Cancer Patients Treated with Platinum-based Chemotherapy. Liblab S et al. 2020 Asian Pacific journal of cancer prevention
32767921 A DNA Repair Pathway Polymorphism (rs25487) and Angiographically Proven Coronary Artery Patients in a Population of Southern Iran. Hoseini SM et al. 2021 Cardiovascular & hematological agents in medicinal chemistry
32880833 Genetic polymorphisms of GSTP1, XRCC1, XPC and ERCC1: prediction of clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer patients of Bangladesh. Bushra MU et al. 2020 Molecular biology reports
32916236 Radiation-induced lymphopenia during chemoradiation therapy for non-small cell lung cancer is linked with age, lung V5, and XRCC1 rs25487 genotypes in lymphocytes. Xie X et al. 2021 Radiotherapy and oncology
33035787 Effect of DPYD, MTHFR, ABCB1, XRCC1, ERCC1 and GSTP1 on chemotherapy related toxicity in colorectal carcinoma. Puerta-García E et al. 2020 Surgical oncology
33171788 Liver Cirrhosis in Chronic Hepatitis B Patients Is Associated with Genetic Variations in DNA Repair Pathway Genes. Rybicka M et al. 2020 Cancers
33262486 Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters. 2020 European journal of human genetics
33558989 Association of XRCC3 rs1799794 polymorphism with survival of glioblastoma multiforme patients treated with combined radio-chemotherapy. Pasqualetti F et al. 2021 Investigational new drugs
33647453 Relationship of the XRCC1 rs25487 polymorphism with demographic, behavioral, clinical, and histological parameters in oral potentially malignant disorders and oral squamous cell carcinoma in a Colombian population. Hernández-Arenas YY et al. 2021 Journal of oral biosciences
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The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

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