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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs1805192

Current Build 154

Released April 21, 2020

Organism
Homo sapiens
Position
chr3:12379739 (GRCh38.p12) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
C>G
Variation Type
SNV Single Nucleotide Variation
Frequency
G=0.00000 (0/78698, PAGE_STUDY)
Clinical Significance
Reported in ClinVar
Gene : Consequence
PPARG : Missense Variant
Publications
68 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p12 chr 3 NC_000003.12:g.12379739C>G
GRCh37.p13 chr 3 NC_000003.11:g.12421238C>G
PPARG RefSeqGene NG_011749.1:g.96890C>G
Gene: PPARG, peroxisome proliferator activated receptor gamma (plus strand)
Molecule type Change Amino acid[Codon] SO Term
PPARG transcript variant 9 NM_001354669.2:c.-400= N/A 5 Prime UTR Variant
PPARG transcript variant 8 NM_001354668.2:c.118C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 4 NP_001341597.1:p.Pro40Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 10 NM_001354670.2:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 6 NP_001341599.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 16 NM_001374266.1:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 8 NP_001361195.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 6 NM_001354666.2:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 1 NP_001341595.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 13 NM_001374263.1:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 1 NP_001361192.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 12 NM_001374262.1:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 3 NP_001361191.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 3 NM_138711.4:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 1 NP_619725.2:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 1 NM_138712.4:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 1 NP_619726.2:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 2 NM_015869.5:c.118C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 2 NP_056953.2:p.Pro40Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 15 NM_001374265.1:c.118C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 7 NP_001361194.1:p.Pro40Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 14 NM_001374264.1:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 1 NP_001361193.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 11 NM_001374261.1:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 3 NP_001361190.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 5 NM_001330615.2:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 3 NP_001317544.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 7 NM_001354667.2:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 1 NP_001341596.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 4 NM_005037.6:c.34C>G P [CCC] > A [GCC] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 1 NP_005028.4:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: G (allele ID: 23170 )
ClinVar Accession Disease Names Clinical Significance
RCV000008604.4 Diabetes mellitus, noninsulin-dependent, modifier of Risk-Factor
RCV000008605.4 Obesity, modifier of Risk-Factor
RCV000008606.5 Body mass index, modifier of Risk-Factor
RCV000008607.4 Intimal medial thickness of internal carotid artery, modifier of Risk-Factor
Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
The PAGE Study Global Study-wide 78698 C=1.00000 G=0.00000
The PAGE Study AfricanAmerican Sub 32516 C=1.00000 G=0.00000
The PAGE Study Mexican Sub 10810 C=1.00000 G=0.00000
The PAGE Study Asian Sub 8316 C=1.0000 G=0.0000
The PAGE Study PuertoRican Sub 7918 C=1.0000 G=0.0000
The PAGE Study NativeHawaiian Sub 4532 C=1.0000 G=0.0000
The PAGE Study Cuban Sub 4230 C=1.0000 G=0.0000
The PAGE Study Dominican Sub 3828 C=1.0000 G=0.0000
The PAGE Study CentralAmerican Sub 2450 C=1.0000 G=0.0000
The PAGE Study SouthAmerican Sub 1982 C=1.0000 G=0.0000
The PAGE Study NativeAmerican Sub 1260 C=1.0000 G=0.0000
The PAGE Study SouthAsian Sub 856 C=1.000 G=0.000
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement C= G
GRCh38.p12 chr 3 NC_000003.12:g.12379739= NC_000003.12:g.12379739C>G
GRCh37.p13 chr 3 NC_000003.11:g.12421238= NC_000003.11:g.12421238C>G
PPARG RefSeqGene NG_011749.1:g.96890= NG_011749.1:g.96890C>G
PPARG transcript variant 4 NM_005037.6:c.34= NM_005037.6:c.34C>G
PPARG transcript variant 4 NM_005037.5:c.34= NM_005037.5:c.34C>G
PPARG transcript variant 2 NM_015869.5:c.118= NM_015869.5:c.118C>G
PPARG transcript variant 2 NM_015869.4:c.118= NM_015869.4:c.118C>G
PPARG transcript variant 1 NM_138712.4:c.34= NM_138712.4:c.34C>G
PPARG transcript variant 1 NM_138712.3:c.34= NM_138712.3:c.34C>G
PPARG transcript variant 3 NM_138711.4:c.34= NM_138711.4:c.34C>G
PPARG transcript variant 3 NM_138711.3:c.34= NM_138711.3:c.34C>G
PPARG transcript variant 8 NM_001354668.2:c.118= NM_001354668.2:c.118C>G
PPARG transcript variant 8 NM_001354668.1:c.118= NM_001354668.1:c.118C>G
PPARG transcript variant 10 NM_001354670.2:c.34= NM_001354670.2:c.34C>G
PPARG transcript variant 10 NM_001354670.1:c.34= NM_001354670.1:c.34C>G
PPARG transcript variant 6 NM_001354666.2:c.34= NM_001354666.2:c.34C>G
PPARG transcript variant 6 NM_001354666.1:c.34= NM_001354666.1:c.34C>G
PPARG transcript variant 7 NM_001354667.2:c.34= NM_001354667.2:c.34C>G
PPARG transcript variant 7 NM_001354667.1:c.34= NM_001354667.1:c.34C>G
PPARG transcript variant 9 NM_001354669.2:c.-400= NM_001354669.2:c.-400C>G
PPARG transcript variant 9 NM_001354669.1:c.-400= NM_001354669.1:c.-400C>G
PPARG transcript variant 5 NM_001330615.2:c.34= NM_001330615.2:c.34C>G
PPARG transcript variant 5 NM_001330615.1:c.34= NM_001330615.1:c.34C>G
PPARG transcript variant 13 NM_001374263.1:c.34= NM_001374263.1:c.34C>G
PPARG transcript variant 14 NM_001374264.1:c.34= NM_001374264.1:c.34C>G
PPARG transcript variant 15 NM_001374265.1:c.118= NM_001374265.1:c.118C>G
PPARG transcript variant 12 NM_001374262.1:c.34= NM_001374262.1:c.34C>G
PPARG transcript variant 11 NM_001374261.1:c.34= NM_001374261.1:c.34C>G
PPARG transcript variant 16 NM_001374266.1:c.34= NM_001374266.1:c.34C>G
peroxisome proliferator-activated receptor gamma isoform 1 NP_005028.4:p.Pro12= NP_005028.4:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 2 NP_056953.2:p.Pro40= NP_056953.2:p.Pro40Ala
peroxisome proliferator-activated receptor gamma isoform 1 NP_619726.2:p.Pro12= NP_619726.2:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 1 NP_619725.2:p.Pro12= NP_619725.2:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 4 NP_001341597.1:p.Pro40= NP_001341597.1:p.Pro40Ala
peroxisome proliferator-activated receptor gamma isoform 6 NP_001341599.1:p.Pro12= NP_001341599.1:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 1 NP_001341595.1:p.Pro12= NP_001341595.1:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 1 NP_001341596.1:p.Pro12= NP_001341596.1:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 3 NP_001317544.1:p.Pro12= NP_001317544.1:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 1 NP_001361192.1:p.Pro12= NP_001361192.1:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 1 NP_001361193.1:p.Pro12= NP_001361193.1:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 7 NP_001361194.1:p.Pro40= NP_001361194.1:p.Pro40Ala
peroxisome proliferator-activated receptor gamma isoform 3 NP_001361191.1:p.Pro12= NP_001361191.1:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 3 NP_001361190.1:p.Pro12= NP_001361190.1:p.Pro12Ala
peroxisome proliferator-activated receptor gamma isoform 8 NP_001361195.1:p.Pro12= NP_001361195.1:p.Pro12Ala
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

7 SubSNP, 1 Frequency, 4 ClinVar submissions
No Submitter Submission ID Date (Build)
1 SNP500CANCER ss48296479 Mar 14, 2006 (126)
2 OMIM-CURATED-RECORDS ss263193823 Oct 28, 2010 (133)
3 ILLUMINA ss1958537963 Feb 12, 2016 (147)
4 ILLUMINA ss3022212475 Nov 08, 2017 (151)
5 ILLUMINA ss3652678603 Oct 11, 2018 (152)
6 ILLUMINA ss3725990896 Jul 13, 2019 (153)
7 PAGE_CC ss3771011327 Jul 13, 2019 (153)
8 The PAGE Study NC_000003.12 - 12379739 Jul 13, 2019 (153)
9 ClinVar RCV000008604.4 Oct 11, 2018 (152)
10 ClinVar RCV000008605.4 Oct 11, 2018 (152)
11 ClinVar RCV000008606.5 Oct 11, 2018 (152)
12 ClinVar RCV000008607.4 Oct 11, 2018 (152)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss1958537963, ss3022212475, ss3652678603 NC_000003.11:12421237:C:G NC_000003.12:12379738:C:G (self)
RCV000008604.4, RCV000008605.4, RCV000008606.5, RCV000008607.4, 232796, ss263193823, ss3725990896, ss3771011327 NC_000003.12:12379738:C:G NC_000003.12:12379738:C:G (self)
ss48296479 NT_022517.18:12361237:C:G NC_000003.12:12379738:C:G (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

68 citations for rs1805192
PMID Title Author Year Journal
9425261 Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation. Yen CJ et al. 1997 Biochemical and biophysical research communications
9792554 Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Beamer BA et al. 1998 Diabetes
9806549 A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Deeb SS et al. 1998 Nature genetics
9918859 Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus. Ringel J et al. 1999 Biochemical and biophysical research communications
10364535 Use of unlinked genetic markers to detect population stratification in association studies. Pritchard JK et al. 1999 American journal of human genetics
10523018 Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women. Valve R et al. 1999 The Journal of clinical endocrinology and metabolism
10843155 Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-gamma2 in Korean diabetic and obese subjects. Oh EY et al. 2000 The Journal of clinical endocrinology and metabolism
10843190 Peroxisome proliferator-activated receptor-gamma2 P12A and type 2 diabetes in Canadian Oji-Cree. Hegele RA et al. 2000 The Journal of clinical endocrinology and metabolism
10973253 The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Altshuler D et al. 2000 Nature genetics
11158005 Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds. Hasstedt SJ et al. 2001 The Journal of clinical endocrinology and metabolism
11836319 Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene. Hara M et al. 2002 The Journal of clinical endocrinology and metabolism
12096349 Testing for population subdivision and association in four case-control studies. Ardlie KG et al. 2002 American journal of human genetics
12161548 Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. Frederiksen L et al. 2002 The Journal of clinical endocrinology and metabolism
12524541 Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Lohmueller KE et al. 2003 Nature genetics
12679463 Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects. Kolehmainen M et al. 2003 The Journal of clinical endocrinology and metabolism
12974743 The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth. Eriksson J et al. 2003 Clinical genetics
14506127 Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass. Memisoglu A et al. 2003 Human molecular genetics
14569127 Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis. Masud S et al. 2003 Journal of medical genetics
14671186 Exon 6 and 2 peroxisome proliferator-activated receptor-gamma polymorphisms in polycystic ovary syndrome. Orio F Jr et al. 2003 The Journal of clinical endocrinology and metabolism
15356014 Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis. Temelkova-Kurktschiev T et al. 2004 The Journal of clinical endocrinology and metabolism
15367918 The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity. Buzzetti R et al. 2004 European journal of human genetics
15562023 The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy. Bulotta A et al. 2005 The Journal of clinical endocrinology and metabolism
15562396 Effects of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala polymorphism on body fat distribution in female Korean subjects. Kim KS et al. 2004 Metabolism
15797964 Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes. Hansen SK et al. 2005 The Journal of clinical endocrinology and metabolism
16783862 PPAR-gamma gene polymorphisms and psoriatic arthritis. Butt C et al. 2006 The Journal of rheumatology
16822823 The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients. Hansen L et al. 2006 The Journal of clinical endocrinology and metabolism
17213274 Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. Florez JC et al. 2007 The Journal of clinical endocrinology and metabolism
17347532 The Genetics of PPARG and the Skeleton. Ackert-Bicknell C et al. 2006 PPAR research
17463246 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research. et al. 2007 Science (New York, N.Y.)
17463248 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Scott LJ et al. 2007 Science (New York, N.Y.)
17463249 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Zeggini E et al. 2007 Science (New York, N.Y.)
18282109 Adaptations to climate in candidate genes for common metabolic disorders. Hancock AM et al. 2008 PLoS genetics
18707223 PPARG by dietary fat interaction influences bone mass in mice and humans. Ackert-Bicknell CL et al. 2008 Journal of bone and mineral research
19041386 Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review. Boes E et al. 2009 Experimental gerontology
19070258 Peroxisome proliferator-activated receptor gamma/Pro12Ala polymorphism and peroxisome proliferator-activated receptor gamma coactivator-1 alpha/Gly482Ser polymorphism in patients with sarcoidosis. Maver A et al. 2008 Sarcoidosis, vasculitis, and diffuse lung diseases
19567509 Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes. Breyer JP et al. 2009 Cancer epidemiology, biomarkers & prevention
19573164 Association study and mutation analysis of adiponectin shows association of variants in APM1 with complex obesity in women. Beckers S et al. 2009 Annals of human genetics
19727905 Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women. Li GH et al. 2010 Osteoporosis international
19736300 Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases. Mori M et al. 2009 The Journal of physiology
20825652 Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study. Dongiovanni P et al. 2010 BMC gastroenterology
21140205 Joint effect of peroxisome proliferator-activated receptor γ genetic polymorphisms and estrogen-related risk factors on breast cancer risk: results from a case-control study in Taiwan. Wu MH et al. 2011 Breast cancer research and treatment
22523693 Nuclear receptor variants in liver disease. Müllenbach R et al. 2012 Journal of lipids
22742565 Germline prognostic markers for urinary bladder cancer: obstacles and opportunities. Chang DW et al. 2012 Urologic oncology
23262340 Gene-gene interactions among PPARα/δ/γ polymorphisms for hypertriglyceridemia in Chinese Han population. Gu SJ et al. 2013 Gene
23545576 Association of peroxisome proliferator-activated receptor α/δ/γ with obesity, and gene-gene interaction, in the Chinese Han population. Luo W et al. 2013 Journal of epidemiology
24460649 PPAR α and PPAR γ polymorphisms as risk factors for dyslipidemia in a Chinese Han population. Gu SJ et al. 2014 Lipids in health and disease
24599720 Effect of obesity on the association between common variations in the PPAR gene and C-reactive protein level in Chinese Han population. Gu SJ et al. 2015 Endocrine
24880474 Analysis on the association between PPARα/γ polymorphisms and lipoprotein(a) in a Chinese Han population. Xie HJ et al. 2014 Molecular genetics and genomics
25089907 REV-ERB ALPHA polymorphism is associated with obesity in the Spanish obese male population. Ruano EG et al. 2014 PloS one
25161890 Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans. Wagner R et al. 2014 Molecular metabolism
25987964 Role of peroxisome proliferator-activated receptors gene polymorphisms in type 2 diabetes and metabolic syndrome. Dong C et al. 2015 World journal of diabetes
26098621 Association and interaction of PPARα, δ, and γ gene polymorphisms with low-density lipoprotein-cholesterol in a Chinese Han population. Fan W et al. 2015 Genetic testing and molecular biomarkers
26475999 Interaction between peroxisome proliferator-activated receptor gamma and smoking on cardiovascular disease. Ding X et al. 2016 Physiology & behavior
26483159 RETRACTED: Association between peroxisome proliferator-activated receptor, UCP3 and lipoprotein lipase gene polymorphisms and obesity in Chinese adolescents. Zou Z et al. 2017 Obesity research & clinical practice
27324555 Single-nucleotide polymorphisms of peroxisome proliferator-activated receptor-γ are associated with systemic lupus erythematosus in a Chinese Han population. Ren DF et al. 2016 Clinical and experimental dermatology
27547017 Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review. Severson TJ et al. 2016 World journal of gastroenterology
28013303 The Impact of Peroxisome Proliferator-Activated Receptor Gamma and Its Interaction with Abdominal Obesity on Diabetic Nephropathy in Chinese Han. Zhang M et al. 2017 Nephron
28123453 Interaction between peroxisome proliferator-activated receptor gamma polymorphism and obesity on type 2 diabetes in a Chinese Han population. Lv X et al. 2017 Diabetology & metabolic syndrome
28346566 Gene- Gene Interaction between PPARG and APOE Gene on Late-Onset Alzheimer's Disease: A Case- Control Study in Chinese Han Population. Wang S et al. 2017 The journal of nutrition, health & aging
28415751 Gene-gene interaction between PPARG and CYP1A1 gene on coronary artery disease in the Chinese Han Population. Zhang X et al. 2017 Oncotarget
28427149 Interaction between PPAR γ and SORL1 gene with Late-Onset Alzheimer's disease in Chinese Han Population. Zhang H et al. 2017 Oncotarget
28577571 Genetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review. Paththinige CS et al. 2017 Lipids in health and disease
28590769 Associations of Genetic Polymorphisms Relevant to Metabolic Pathway of Vitamin D3 with Development and Prognosis of Childhood Bronchial Asthma. Zhang Y et al. 2017 DNA and cell biology
28669518 Impact of Interaction Between PPAR Alpha and PPAR Gamma on Breast Cancer Risk in the Chinese Han Population. Lianggeng X et al. 2017 Clinical breast cancer
29060989 [Association and effects of gene-gene interactions between peroxisome proliferator-activated receptor and pulse pressure]. Zhou H et al. 2017 Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
30181995 Haplotype Analysis of PPARγ Gene Polymorphisms and the Lipoprotein (a) Level. Shen C et al. 2018 Iranian journal of public health
31231424 Genetic and Epigenetic Studies in Diabetic Kidney Disease. Gu HF et al. 2019 Frontiers in genetics
31823921 Determination of individual type 2 diabetes risk profile in the North East Indian population & its association with anthropometric parameters. Sarkar P et al. 2019 The Indian journal of medical research
Help

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post536+f5d31d6