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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.


Current Build 155

Released April 9, 2021

Homo sapiens
chr3:12351626 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

C>G / C>T
Variation Type
SNV Single Nucleotide Variation
G=0.080456 (21296/264690, TOPMED)
G=0.110061 (27634/251078, GnomAD_exome)
G=0.088157 (12349/140080, GnomAD) (+ 24 more)
G=0.110140 (13354/121246, ExAC)
G=0.104546 (12165/116360, ALFA)
G=0.05493 (4323/78702, PAGE_STUDY)
G=0.02995 (502/16760, 8.3KJPN)
G=0.0703 (352/5008, 1000G)
G=0.1638 (734/4480, Estonian)
G=0.1194 (460/3854, ALSPAC)
G=0.1081 (401/3708, TWINSUK)
G=0.0517 (151/2922, KOREAN)
G=0.0523 (84/1606, HapMap)
G=0.0960 (109/1136, Daghestan)
G=0.115 (115/998, GoNL)
G=0.073 (58/792, PRJEB37584)
G=0.026 (16/616, Vietnamese)
G=0.128 (77/600, NorthernSweden)
G=0.079 (42/534, MGP)
G=0.168 (51/304, FINRISK)
G=0.019 (4/216, Qatari)
G=0.054 (10/186, PharmGKB)
G=0.15 (12/82, Ancient Sardinia)
C=0.47 (28/60, SGDP_PRJ)
G=0.12 (5/40, GENOME_DK)
C=0.50 (7/14, Siberian)
G=0.50 (7/14, Siberian)
Clinical Significance
Reported in ClinVar
Gene : Consequence
PPARG : Missense Variant
389 citations
Genomic View
See rs on genome

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 3 NC_000003.12:g.12351626C>G
GRCh38.p13 chr 3 NC_000003.12:g.12351626C>T
GRCh37.p13 chr 3 NC_000003.11:g.12393125C>G
GRCh37.p13 chr 3 NC_000003.11:g.12393125C>T
PPARG RefSeqGene NG_011749.1:g.68777C>G
PPARG RefSeqGene NG_011749.1:g.68777C>T
Gene: PPARG, peroxisome proliferator activated receptor gamma (plus strand)
Molecule type Change Amino acid[Codon] SO Term
PPARG transcript variant 5 NM_001330615.4:c.-8-28078…


N/A Intron Variant
PPARG transcript variant 6 NM_001354666.3:c.-8-28078…


N/A Intron Variant
PPARG transcript variant 7 NM_001354667.3:c.-8-28078…


N/A Intron Variant
PPARG transcript variant 9 NM_001354669.2:c.-435-280…


N/A Intron Variant
PPARG transcript variant 10 NM_001354670.2:c.-2-28078…


N/A Intron Variant
PPARG transcript variant 11 NM_001374261.3:c.-8-28078…


N/A Intron Variant
PPARG transcript variant 12 NM_001374262.3:c.-9+6732C…


N/A Intron Variant
PPARG transcript variant 13 NM_001374263.2:c.-8-28078…


N/A Intron Variant
PPARG transcript variant 14 NM_001374264.2:c.-8-28078…


N/A Intron Variant
PPARG transcript variant 16 NM_001374266.1:c.-2-28078…


N/A Intron Variant
PPARG transcript variant 4 NM_005037.7:c.-8-28078C>G N/A Intron Variant
PPARG transcript variant 3 NM_138711.6:c.-8-28078C>G N/A Intron Variant
PPARG transcript variant 1 NM_138712.5:c.-8-28078C>G N/A Intron Variant
PPARG transcript variant 8 NM_001354668.2:c.34C>G P [CCA] > A [GCA] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 4 NP_001341597.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 8 NM_001354668.2:c.34C>T P [CCA] > S [TCA] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 4 NP_001341597.1:p.Pro12Ser P (Pro) > S (Ser) Missense Variant
PPARG transcript variant 2 NM_015869.5:c.34C>G P [CCA] > A [GCA] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 2 NP_056953.2:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 2 NM_015869.5:c.34C>T P [CCA] > S [TCA] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 2 NP_056953.2:p.Pro12Ser P (Pro) > S (Ser) Missense Variant
PPARG transcript variant 15 NM_001374265.1:c.34C>G P [CCA] > A [GCA] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 7 NP_001361194.1:p.Pro12Ala P (Pro) > A (Ala) Missense Variant
PPARG transcript variant 15 NM_001374265.1:c.34C>T P [CCA] > S [TCA] Coding Sequence Variant
peroxisome proliferator-activated receptor gamma isoform 7 NP_001361194.1:p.Pro12Ser P (Pro) > S (Ser) Missense Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: G (allele ID: 135465 )
ClinVar Accession Disease Names Clinical Significance
RCV000118044.2 not specified Likely-Benign
RCV000300998.2 Diabetes Mellitus, Noninsulin-Dependent, with Acanthosis Nigricans and Hypertension Likely-Benign
RCV000336176.2 Familial partial lipodystrophy 3 Likely-Benign
RCV000406618.2 Obesity Likely-Benign

ALFA Allele Frequency (New)
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 116360 C=0.895454 G=0.104546, T=0.000000
European Sub 98794 C=0.88728 G=0.11272, T=0.00000
African Sub 4306 C=0.9863 G=0.0137, T=0.0000
African Others Sub 172 C=0.994 G=0.006, T=0.000
African American Sub 4134 C=0.9860 G=0.0140, T=0.0000
Asian Sub 3322 C=0.9600 G=0.0400, T=0.0000
East Asian Sub 2666 C=0.9591 G=0.0409, T=0.0000
Other Asian Sub 656 C=0.963 G=0.037, T=0.000
Latin American 1 Sub 772 C=0.961 G=0.039, T=0.000
Latin American 2 Sub 850 C=0.953 G=0.047, T=0.000
South Asian Sub 248 C=0.907 G=0.093, T=0.000
Other Sub 8068 C=0.9078 G=0.0922, T=0.0000


Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 C=0.919544 G=0.080456
gnomAD - Exomes Global Study-wide 251078 C=0.889939 G=0.110061
gnomAD - Exomes European Sub 135098 C=0.869791 G=0.130209
gnomAD - Exomes Asian Sub 48980 C=0.91156 G=0.08844
gnomAD - Exomes American Sub 34558 C=0.87951 G=0.12049
gnomAD - Exomes African Sub 16256 C=0.97995 G=0.02005
gnomAD - Exomes Ashkenazi Jewish Sub 10062 C=0.94345 G=0.05655
gnomAD - Exomes Other Sub 6124 C=0.8935 G=0.1065
gnomAD - Genomes Global Study-wide 140080 C=0.911843 G=0.088157
gnomAD - Genomes European Sub 75860 C=0.87038 G=0.12962
gnomAD - Genomes African Sub 41982 C=0.97825 G=0.02175
gnomAD - Genomes American Sub 13642 C=0.91680 G=0.08320
gnomAD - Genomes Ashkenazi Jewish Sub 3320 C=0.9407 G=0.0593
gnomAD - Genomes East Asian Sub 3130 C=0.9610 G=0.0390
gnomAD - Genomes Other Sub 2146 C=0.9306 G=0.0694
ExAC Global Study-wide 121246 C=0.889860 G=0.110140
ExAC Europe Sub 73304 C=0.87409 G=0.12591
ExAC Asian Sub 25102 C=0.90634 G=0.09366
ExAC American Sub 11528 C=0.87205 G=0.12795
ExAC African Sub 10404 C=0.98039 G=0.01961
ExAC Other Sub 908 C=0.896 G=0.104
The PAGE Study Global Study-wide 78702 C=0.94507 G=0.05493
The PAGE Study AfricanAmerican Sub 32516 C=0.97703 G=0.02297
The PAGE Study Mexican Sub 10810 C=0.88612 G=0.11388
The PAGE Study Asian Sub 8318 C=0.9571 G=0.0429
The PAGE Study PuertoRican Sub 7918 C=0.9337 G=0.0663
The PAGE Study NativeHawaiian Sub 4534 C=0.9332 G=0.0668
The PAGE Study Cuban Sub 4230 C=0.9293 G=0.0707
The PAGE Study Dominican Sub 3828 C=0.9653 G=0.0347
The PAGE Study CentralAmerican Sub 2450 C=0.8980 G=0.1020
The PAGE Study SouthAmerican Sub 1982 C=0.8865 G=0.1135
The PAGE Study NativeAmerican Sub 1260 C=0.8833 G=0.1167
The PAGE Study SouthAsian Sub 856 C=0.876 G=0.124
8.3KJPN JAPANESE Study-wide 16760 C=0.97005 G=0.02995
1000Genomes Global Study-wide 5008 C=0.9297 G=0.0703
1000Genomes African Sub 1322 C=0.9947 G=0.0053
1000Genomes East Asian Sub 1008 C=0.9742 G=0.0258
1000Genomes Europe Sub 1006 C=0.8797 G=0.1203
1000Genomes South Asian Sub 978 C=0.880 G=0.120
1000Genomes American Sub 694 C=0.883 G=0.117
Genetic variation in the Estonian population Estonian Study-wide 4480 C=0.8362 G=0.1638
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 C=0.8806 G=0.1194
UK 10K study - Twins TWIN COHORT Study-wide 3708 C=0.8919 G=0.1081
KOREAN population from KRGDB KOREAN Study-wide 2922 C=0.9483 G=0.0517
HapMap Global Study-wide 1606 C=0.9477 G=0.0523
HapMap American Sub 770 C=0.930 G=0.070
HapMap African Sub 406 C=0.988 G=0.012
HapMap Asian Sub 254 C=0.953 G=0.047
HapMap Europe Sub 176 C=0.926 G=0.074
Genome-wide autozygosity in Daghestan Global Study-wide 1136 C=0.9040 G=0.0960
Genome-wide autozygosity in Daghestan Daghestan Sub 628 C=0.908 G=0.092
Genome-wide autozygosity in Daghestan Near_East Sub 144 C=0.917 G=0.083
Genome-wide autozygosity in Daghestan Central Asia Sub 122 C=0.902 G=0.098
Genome-wide autozygosity in Daghestan Europe Sub 108 C=0.907 G=0.093
Genome-wide autozygosity in Daghestan South Asian Sub 98 C=0.89 G=0.11
Genome-wide autozygosity in Daghestan Caucasus Sub 36 C=0.83 G=0.17
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 C=0.885 G=0.115
CNV burdens in cranial meningiomas Global Study-wide 792 C=0.927 G=0.073
CNV burdens in cranial meningiomas CRM Sub 792 C=0.927 G=0.073
A Vietnamese Genetic Variation Database Global Study-wide 616 C=0.974 G=0.026
Northern Sweden ACPOP Study-wide 600 C=0.872 G=0.128
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 C=0.921 G=0.079
FINRISK Finnish from FINRISK project Study-wide 304 C=0.832 G=0.168
Qatari Global Study-wide 216 C=0.981 G=0.019
PharmGKB Aggregated Global Study-wide 186 C=0.946 G=0.054
PharmGKB Aggregated PA130229643 Sub 94 C=0.95 G=0.05
PharmGKB Aggregated PA130217363 Sub 92 C=0.95 G=0.05
Ancient Sardinia genome-wide 1240k capture data generation and analysis Global Study-wide 82 C=0.85 G=0.15
SGDP_PRJ Global Study-wide 60 C=0.47 G=0.53
The Danish reference pan genome Danish Study-wide 40 C=0.88 G=0.12
Siberian Global Study-wide 14 C=0.50 G=0.50

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement C= G T
GRCh38.p13 chr 3 NC_000003.12:g.12351626= NC_000003.12:g.12351626C>G NC_000003.12:g.12351626C>T
GRCh37.p13 chr 3 NC_000003.11:g.12393125= NC_000003.11:g.12393125C>G NC_000003.11:g.12393125C>T
PPARG RefSeqGene NG_011749.1:g.68777= NG_011749.1:g.68777C>G NG_011749.1:g.68777C>T
PPARG transcript variant 2 NM_015869.5:c.34= NM_015869.5:c.34C>G NM_015869.5:c.34C>T
PPARG transcript variant 2 NM_015869.4:c.34= NM_015869.4:c.34C>G NM_015869.4:c.34C>T
PPARG transcript variant 8 NM_001354668.2:c.34= NM_001354668.2:c.34C>G NM_001354668.2:c.34C>T
PPARG transcript variant 8 NM_001354668.1:c.34= NM_001354668.1:c.34C>G NM_001354668.1:c.34C>T
PPARG transcript variant 15 NM_001374265.1:c.34= NM_001374265.1:c.34C>G NM_001374265.1:c.34C>T
peroxisome proliferator-activated receptor gamma isoform 2 NP_056953.2:p.Pro12= NP_056953.2:p.Pro12Ala NP_056953.2:p.Pro12Ser
peroxisome proliferator-activated receptor gamma isoform 4 NP_001341597.1:p.Pro12= NP_001341597.1:p.Pro12Ala NP_001341597.1:p.Pro12Ser
peroxisome proliferator-activated receptor gamma isoform 7 NP_001361194.1:p.Pro12= NP_001361194.1:p.Pro12Ala NP_001361194.1:p.Pro12Ser
PPARG transcript variant 5 NM_001330615.4:c.-8-28078= NM_001330615.4:c.-8-28078C>G NM_001330615.4:c.-8-28078C>T
PPARG transcript variant 6 NM_001354666.3:c.-8-28078= NM_001354666.3:c.-8-28078C>G NM_001354666.3:c.-8-28078C>T
PPARG transcript variant 7 NM_001354667.3:c.-8-28078= NM_001354667.3:c.-8-28078C>G NM_001354667.3:c.-8-28078C>T
PPARG transcript variant 9 NM_001354669.2:c.-435-28078= NM_001354669.2:c.-435-28078C>G NM_001354669.2:c.-435-28078C>T
PPARG transcript variant 10 NM_001354670.2:c.-2-28078= NM_001354670.2:c.-2-28078C>G NM_001354670.2:c.-2-28078C>T
PPARG transcript variant 11 NM_001374261.3:c.-8-28078= NM_001374261.3:c.-8-28078C>G NM_001374261.3:c.-8-28078C>T
PPARG transcript variant 12 NM_001374262.3:c.-9+6732= NM_001374262.3:c.-9+6732C>G NM_001374262.3:c.-9+6732C>T
PPARG transcript variant 13 NM_001374263.2:c.-8-28078= NM_001374263.2:c.-8-28078C>G NM_001374263.2:c.-8-28078C>T
PPARG transcript variant 14 NM_001374264.2:c.-8-28078= NM_001374264.2:c.-8-28078C>G NM_001374264.2:c.-8-28078C>T
PPARG transcript variant 16 NM_001374266.1:c.-2-28078= NM_001374266.1:c.-2-28078C>G NM_001374266.1:c.-2-28078C>T
PPARG transcript variant 4 NM_005037.5:c.-2-28078= NM_005037.5:c.-2-28078C>G NM_005037.5:c.-2-28078C>T
PPARG transcript variant 4 NM_005037.7:c.-8-28078= NM_005037.7:c.-8-28078C>G NM_005037.7:c.-8-28078C>T
PPARG transcript variant 3 NM_138711.3:c.-2-28078= NM_138711.3:c.-2-28078C>G NM_138711.3:c.-2-28078C>T
PPARG transcript variant 3 NM_138711.6:c.-8-28078= NM_138711.6:c.-8-28078C>G NM_138711.6:c.-8-28078C>T
PPARG transcript variant 1 NM_138712.3:c.-2-28078= NM_138712.3:c.-2-28078C>G NM_138712.3:c.-2-28078C>T
PPARG transcript variant 1 NM_138712.5:c.-8-28078= NM_138712.5:c.-8-28078C>G NM_138712.5:c.-8-28078C>T

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

142 SubSNP, 26 Frequency, 4 ClinVar submissions
No Submitter Submission ID Date (Build)
1 HGBASE ss2421521 Nov 14, 2000 (89)
2 PGA-UW-FHCRC ss5587532 Oct 08, 2002 (108)
3 IBARROSO ss12587275 Aug 26, 2003 (117)
4 SSAHASNP ss21914363 Apr 05, 2004 (121)
5 IMCJ-GDT ss22887914 Apr 05, 2004 (121)
6 PARC ss23143926 Sep 20, 2004 (126)
7 PERLEGEN ss24301991 Sep 20, 2004 (123)
8 PGA-UW-FHCRC ss28447437 Sep 20, 2004 (123)
9 ABI ss44380891 Mar 11, 2006 (126)
10 RIVM-TOX ss46533761 Mar 11, 2006 (126)
11 SNP500CANCER ss48296480 Mar 16, 2006 (126)
12 APPLERA_GI ss48423639 Mar 11, 2006 (126)
13 AFFY ss66009632 Nov 29, 2006 (127)
14 AFFY ss66351788 Nov 29, 2006 (127)
15 PERLEGEN ss68853144 May 16, 2007 (127)
16 PHARMGKB_PARC ss69364862 May 16, 2007 (127)
17 PHARMGKB_PARC ss69365041 May 16, 2007 (127)
18 ILLUMINA ss74878796 Dec 06, 2007 (129)
19 AFFY ss76064088 Dec 08, 2007 (130)
20 SI_EXO ss76886233 Dec 06, 2007 (129)
21 KRIBB_YJKIM ss81587013 Dec 14, 2007 (130)
22 CANCER-GENOME ss86343230 Mar 23, 2008 (129)
23 HUMANGENOME_JCVI ss95985793 Feb 03, 2009 (130)
24 BGI ss103902055 Dec 01, 2009 (131)
25 ENSEMBL ss135527614 Dec 01, 2009 (131)
26 ILLUMINA ss160463025 Dec 01, 2009 (131)
27 AFFY ss172373238 Jul 04, 2010 (132)
28 ILLUMINA ss172925497 Jul 04, 2010 (132)
29 PAGE_STUDY ss181341867 Jul 04, 2010 (132)
30 PAGE_STUDY ss181835474 Jul 04, 2010 (132)
31 PAGE_STUDY ss181835892 Jul 04, 2010 (132)
32 PAGE_STUDY ss182258815 Jul 04, 2010 (132)
33 PAGE_STUDY ss182258845 Jul 04, 2010 (132)
34 1000GENOMES ss231711040 Jul 14, 2010 (132)
35 1000GENOMES ss239144608 Jul 15, 2010 (132)
36 OMICIA ss244238258 May 27, 2010 (132)
37 ILLUMINA ss244285129 Jul 04, 2010 (132)
38 BL ss252938256 May 09, 2011 (134)
39 GMI ss277017197 May 04, 2012 (137)
40 PJP ss292934004 May 09, 2011 (134)
41 NHLBI-ESP ss342114366 May 09, 2011 (134)
42 ILLUMINA ss410841189 Sep 17, 2011 (135)
43 ILLUMINA ss480300997 May 04, 2012 (137)
44 ILLUMINA ss480312111 May 04, 2012 (137)
45 ILLUMINA ss481067895 Sep 08, 2015 (146)
46 ILLUMINA ss484948311 May 04, 2012 (137)
47 1000GENOMES ss489865615 May 04, 2012 (137)
48 EXOME_CHIP ss491335705 May 04, 2012 (137)
49 CLINSEQ_SNP ss491829272 May 04, 2012 (137)
50 ILLUMINA ss536094689 Sep 08, 2015 (146)
51 ILLUMINA ss536992457 Sep 08, 2015 (146)
52 TISHKOFF ss556430985 Apr 25, 2013 (138)
53 SSMP ss650097436 Apr 25, 2013 (138)
54 ILLUMINA ss778656867 Aug 21, 2014 (142)
55 ILLUMINA ss780813559 Aug 21, 2014 (142)
56 ILLUMINA ss782920463 Aug 21, 2014 (142)
57 ILLUMINA ss783495615 Aug 21, 2014 (142)
58 ILLUMINA ss783883489 Aug 21, 2014 (142)
59 ILLUMINA ss832175590 Apr 01, 2015 (144)
60 ILLUMINA ss834114824 Aug 21, 2014 (142)
61 OMIM-CURATED-RECORDS ss947846638 Jan 22, 2014 (138)
62 OMIM-CURATED-RECORDS ss947848881 Jan 28, 2014 (138)
63 OMIM-CURATED-RECORDS ss947850201 Feb 04, 2014 (138)
64 OMIM-CURATED-RECORDS ss974293101 Jun 03, 2014 (141)
65 JMKIDD_LAB ss974447037 Aug 21, 2014 (142)
66 EVA-GONL ss978280023 Aug 21, 2014 (142)
67 JMKIDD_LAB ss1067448368 Aug 21, 2014 (142)
68 JMKIDD_LAB ss1070181072 Aug 21, 2014 (142)
69 1000GENOMES ss1302833483 Aug 21, 2014 (142)
70 HAMMER_LAB ss1397329900 Sep 08, 2015 (146)
71 EVA_GENOME_DK ss1579848474 Apr 01, 2015 (144)
72 EVA_FINRISK ss1584025924 Apr 01, 2015 (144)
73 EVA_DECODE ss1587741465 Apr 01, 2015 (144)
74 EVA_UK10K_ALSPAC ss1606431028 Apr 01, 2015 (144)
75 EVA_UK10K_TWINSUK ss1649425061 Apr 01, 2015 (144)
76 EVA_EXAC ss1686873269 Apr 01, 2015 (144)
77 EVA_MGP ss1711007718 Apr 01, 2015 (144)
78 EVA_SVP ss1712554458 Apr 01, 2015 (144)
79 ILLUMINA ss1752436609 Sep 08, 2015 (146)
80 ILLUMINA ss1917763393 Feb 12, 2016 (147)
81 WEILL_CORNELL_DGM ss1921532588 Feb 12, 2016 (147)
82 ILLUMINA ss1946074799 Feb 12, 2016 (147)
83 ILLUMINA ss1958537935 Feb 12, 2016 (147)
84 GENOMED ss1969325361 Jul 19, 2016 (147)
85 JJLAB ss2021319468 Sep 14, 2016 (149)
86 USC_VALOUEV ss2149387220 Dec 20, 2016 (150)
87 HUMAN_LONGEVITY ss2249137180 Dec 20, 2016 (150)
88 TOPMED ss2416180505 Dec 20, 2016 (150)
89 SYSTEMSBIOZJU ss2625160035 Nov 08, 2017 (151)
90 ILLUMINA ss2633912619 Nov 08, 2017 (151)
91 ILLUMINA ss2633912620 Nov 08, 2017 (151)
92 GRF ss2704747940 Nov 08, 2017 (151)
93 GNOMAD ss2733547378 Nov 08, 2017 (151)
94 GNOMAD ss2746947697 Nov 08, 2017 (151)
95 GNOMAD ss2789618248 Nov 08, 2017 (151)
96 AFFY ss2985247271 Nov 08, 2017 (151)
97 AFFY ss2985868338 Nov 08, 2017 (151)
98 SWEGEN ss2991841947 Nov 08, 2017 (151)
99 ILLUMINA ss3022212451 Nov 08, 2017 (151)
100 BIOINF_KMB_FNS_UNIBA ss3024422696 Nov 08, 2017 (151)
101 CSHL ss3344889070 Nov 08, 2017 (151)
102 TOPMED ss3382865436 Nov 08, 2017 (151)
103 ILLUMINA ss3628592064 Oct 11, 2018 (152)
104 ILLUMINA ss3628592065 Oct 11, 2018 (152)
105 ILLUMINA ss3628592066 Oct 11, 2018 (152)
106 ILLUMINA ss3631861132 Oct 11, 2018 (152)
107 ILLUMINA ss3633282347 Oct 11, 2018 (152)
108 ILLUMINA ss3633998836 Oct 11, 2018 (152)
109 ILLUMINA ss3634880715 Oct 11, 2018 (152)
110 ILLUMINA ss3636576888 Oct 11, 2018 (152)
111 ILLUMINA ss3638397631 Oct 11, 2018 (152)
112 ILLUMINA ss3640588018 Oct 11, 2018 (152)
113 ILLUMINA ss3643355925 Oct 11, 2018 (152)
114 ILLUMINA ss3644807350 Oct 11, 2018 (152)
115 OMUKHERJEE_ADBS ss3646282934 Oct 11, 2018 (152)
116 URBANLAB ss3647342604 Oct 11, 2018 (152)
117 ILLUMINA ss3652678577 Oct 11, 2018 (152)
118 ILLUMINA ss3654015795 Oct 11, 2018 (152)
119 EGCUT_WGS ss3659742047 Jul 13, 2019 (153)
120 EVA_DECODE ss3708652020 Jul 13, 2019 (153)
121 ILLUMINA ss3725990876 Jul 13, 2019 (153)
122 ACPOP ss3729638770 Jul 13, 2019 (153)
123 ILLUMINA ss3744506235 Jul 13, 2019 (153)
124 ILLUMINA ss3745180519 Jul 13, 2019 (153)
125 EVA ss3759670977 Jul 13, 2019 (153)
126 PAGE_CC ss3771011305 Jul 13, 2019 (153)
127 ILLUMINA ss3772676305 Jul 13, 2019 (153)
128 KHV_HUMAN_GENOMES ss3802820217 Jul 13, 2019 (153)
129 EVA ss3823884907 Apr 25, 2020 (154)
130 EVA ss3825626612 Apr 25, 2020 (154)
131 EVA ss3827665682 Apr 25, 2020 (154)
132 SGDP_PRJ ss3855242975 Apr 25, 2020 (154)
133 KRGDB ss3901017115 Apr 25, 2020 (154)
134 FSA-LAB ss3984242826 Apr 27, 2021 (155)
135 EVA ss3984503130 Apr 27, 2021 (155)
136 EVA ss3984973518 Apr 27, 2021 (155)
137 EVA ss3986228279 Apr 27, 2021 (155)
138 EVA ss4017065359 Apr 27, 2021 (155)
139 TOPMED ss4554465733 Apr 27, 2021 (155)
140 TOMMO_GENOMICS ss5157833545 Apr 27, 2021 (155)
141 EVA ss5236994018 Apr 27, 2021 (155)
142 EVA ss5237318452 Apr 27, 2021 (155)
143 1000Genomes NC_000003.11 - 12393125 Oct 11, 2018 (152)
144 The Avon Longitudinal Study of Parents and Children NC_000003.11 - 12393125 Oct 11, 2018 (152)
145 Genome-wide autozygosity in Daghestan NC_000003.10 - 12368125 Apr 25, 2020 (154)
146 Genetic variation in the Estonian population NC_000003.11 - 12393125 Oct 11, 2018 (152)
147 ExAC NC_000003.11 - 12393125 Oct 11, 2018 (152)
148 FINRISK NC_000003.11 - 12393125 Apr 25, 2020 (154)
149 The Danish reference pan genome NC_000003.11 - 12393125 Apr 25, 2020 (154)
150 gnomAD - Genomes NC_000003.12 - 12351626 Apr 27, 2021 (155)
151 gnomAD - Exomes NC_000003.11 - 12393125 Jul 13, 2019 (153)
152 Genome of the Netherlands Release 5 NC_000003.11 - 12393125 Apr 25, 2020 (154)
153 HapMap NC_000003.12 - 12351626 Apr 25, 2020 (154)
154 KOREAN population from KRGDB NC_000003.11 - 12393125 Apr 25, 2020 (154)
155 Medical Genome Project healthy controls from Spanish population NC_000003.11 - 12393125 Apr 25, 2020 (154)
156 Northern Sweden NC_000003.11 - 12393125 Jul 13, 2019 (153)
157 The PAGE Study NC_000003.12 - 12351626 Jul 13, 2019 (153)
158 Ancient Sardinia genome-wide 1240k capture data generation and analysis NC_000003.11 - 12393125 Apr 27, 2021 (155)
159 CNV burdens in cranial meningiomas NC_000003.11 - 12393125 Apr 27, 2021 (155)
160 PharmGKB Aggregated NC_000003.12 - 12351626 Apr 25, 2020 (154)
161 Qatari NC_000003.11 - 12393125 Apr 25, 2020 (154)
162 SGDP_PRJ NC_000003.11 - 12393125 Apr 25, 2020 (154)
163 Siberian NC_000003.11 - 12393125 Apr 25, 2020 (154)
164 8.3KJPN NC_000003.11 - 12393125 Apr 27, 2021 (155)
165 TopMed NC_000003.12 - 12351626 Apr 27, 2021 (155)
166 UK 10K study - Twins NC_000003.11 - 12393125 Oct 11, 2018 (152)
167 A Vietnamese Genetic Variation Database NC_000003.11 - 12393125 Jul 13, 2019 (153)
168 ALFA NC_000003.12 - 12351626 Apr 27, 2021 (155)
169 ClinVar RCV000118044.2 Oct 11, 2018 (152)
170 ClinVar RCV000300998.2 Apr 27, 2021 (155)
171 ClinVar RCV000336176.2 Apr 27, 2021 (155)
172 ClinVar RCV000406618.2 Apr 27, 2021 (155)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs17241090 Mar 11, 2006 (126)
rs17749580 Oct 07, 2004 (123)
rs36206375 Oct 25, 2006 (127)
rs56460253 May 23, 2008 (130)
rs57327233 Feb 26, 2009 (130)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
306000, ss66351788, ss76064088, ss160463025, ss172373238, ss244285129, ss252938256, ss277017197, ss292934004, ss410841189, ss480300997, ss491829272, ss1397329900, ss1587741465, ss1712554458, ss3643355925 NC_000003.10:12368124:C:G NC_000003.12:12351625:C:G (self)
13979456, 7749709, 5480295, 6787755, 22385, 6013413, 2619217, 3402561, 8194509, 124257, 2923635, 199445, 52473, 3574518, 7259955, 1903574, 15802852, 7749709, 1687467, ss231711040, ss239144608, ss342114366, ss480312111, ss481067895, ss484948311, ss489865615, ss491335705, ss536094689, ss536992457, ss556430985, ss650097436, ss778656867, ss780813559, ss782920463, ss783495615, ss783883489, ss832175590, ss834114824, ss974447037, ss978280023, ss1067448368, ss1070181072, ss1302833483, ss1579848474, ss1584025924, ss1606431028, ss1649425061, ss1686873269, ss1711007718, ss1752436609, ss1917763393, ss1921532588, ss1946074799, ss1958537935, ss1969325361, ss2021319468, ss2149387220, ss2416180505, ss2625160035, ss2633912619, ss2633912620, ss2704747940, ss2733547378, ss2746947697, ss2789618248, ss2985247271, ss2985868338, ss2991841947, ss3022212451, ss3344889070, ss3628592064, ss3628592065, ss3628592066, ss3631861132, ss3633282347, ss3633998836, ss3634880715, ss3636576888, ss3638397631, ss3640588018, ss3644807350, ss3646282934, ss3652678577, ss3654015795, ss3659742047, ss3729638770, ss3744506235, ss3745180519, ss3759670977, ss3772676305, ss3823884907, ss3825626612, ss3827665682, ss3855242975, ss3901017115, ss3984242826, ss3984503130, ss3984973518, ss3986228279, ss4017065359, ss5157833545, ss5237318452 NC_000003.11:12393124:C:G NC_000003.12:12351625:C:G (self)
RCV000118044.2, RCV000300998.2, RCV000336176.2, RCV000406618.2, 99252373, 2304355, 232774, 7902, 244822108, 391843288, 4668752225, ss244238258, ss947846638, ss947848881, ss947850201, ss974293101, ss2249137180, ss3024422696, ss3382865436, ss3647342604, ss3708652020, ss3725990876, ss3771011305, ss3802820217, ss4554465733, ss5236994018 NC_000003.12:12351625:C:G NC_000003.12:12351625:C:G (self)
ss21914363 NT_022517.16:12333124:C:G NC_000003.12:12351625:C:G (self)
ss76886233 NT_022517.17:12333124:C:G NC_000003.12:12351625:C:G (self)
ss2421521, ss5587532, ss12587275, ss22887914, ss23143926, ss24301991, ss28447437, ss44380891, ss46533761, ss48296480, ss48423639, ss66009632, ss68853144, ss69364862, ss69365041, ss74878796, ss81587013, ss86343230, ss95985793, ss103902055, ss135527614, ss172925497, ss181341867, ss181835474, ss181835892, ss182258815, ss182258845 NT_022517.18:12333124:C:G NC_000003.12:12351625:C:G (self)
4668752225 NC_000003.12:12351625:C:T NC_000003.12:12351625:C:T

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

389 citations for rs1801282
PMID Title Author Year Journal
9792554 Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Beamer BA et al. 1998 Diabetes
16713673 Variations in the peroxisome proliferator-activated receptor-gamma gene and melanoma risk. Mössner R et al. 2007 Cancer letters
16783862 PPAR-gamma gene polymorphisms and psoriatic arthritis. Butt C et al. 2006 The Journal of rheumatology
17094261 Effect of the peroxisome proliferators-activated receptor (PPAR) gamma 3 gene on BMI in 1,210 school students from Morelos, Mexico. Chen L et al. 2006 Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
17187763 Analysis of PGC-1alpha variants Gly482Ser and Thr612Met concerning their PPARgamma2-coactivation function. Nitz I et al. 2007 Biochemical and biophysical research communications
17213274 Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. Florez JC et al. 2007 The Journal of clinical endocrinology and metabolism
17348446 Nested case-control study of energy regulation candidate gene single nucleotide polymorphisms and breast cancer. Wang Y et al. 2007 Anticancer research
17355643 Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. Huang HY et al. 2007 BMC genetics
17570749 Genetic prediction of future type 2 diabetes. Lyssenko V et al. 2005 PLoS medicine
17786212 Heterogeneity in meta-analyses of genome-wide association investigations. Ioannidis JP et al. 2007 PloS one
17825092 Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. Nemoto M et al. 2007 Cardiovascular diabetology
17903291 The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. Cupples LA et al. 2007 BMC medical genetics
17903298 Genome-wide association with diabetes-related traits in the Framingham Heart Study. Meigs JB et al. 2007 BMC medical genetics
17903300 Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. Fox CS et al. 2007 BMC medical genetics
18091023 SNPs in PPARG associate with type 2 diabetes and interact with physical activity. Kilpeläinen TO et al. 2008 Medicine and science in sports and exercise
18160840 The association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma gene with serum osteoprotegerin levels in healthy Korean women. Rhee EJ et al. 2007 Experimental & molecular medicine
18162508 Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Omori S et al. 2008 Diabetes
18224312 Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. Brockmöller J et al. 2008 European journal of clinical pharmacology
18280041 PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes. Johnson W et al. 2008 Neuroscience letters
18282109 Adaptations to climate in candidate genes for common metabolic disorders. Hancock AM et al. 2008 PLoS genetics
18288282 Genetic polymorphisms of peroxisome proliferator-activated receptors and the risk of cardiovascular morbidity and mortality in a community-based cohort in washington county, Maryland. Gallicchio L et al. 2008 PPAR research
18304332 No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins. Haworth CM et al. 2008 BMC medical genetics
18319073 Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes. Lu Q et al. 2008 American journal of human genetics
18340007 Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia. Mar-Heyming R et al. 2008 Arteriosclerosis, thrombosis, and vascular biology
18372903 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Zeggini E et al. 2008 Nature genetics
18401448 PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease. Cresci S et al. 2008 PPAR research
18426861 Association analysis of type 2 diabetes Loci in type 1 diabetes. Qu HQ et al. 2008 Diabetes
18426866 Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Marvelle AF et al. 2008 Diabetes
18498634 The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. Cauchi S et al. 2008 BMC medical genetics
18513389 New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. Penco S et al. 2008 BMC bioinformatics
18533027 Worldwide population differentiation at disease-associated SNPs. Myles S et al. 2008 BMC medical genomics
18591388 Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Lango H et al. 2008 Diabetes
18598350 Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. Sanghera DK et al. 2008 BMC medical genetics
18603647 Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response. Simoni M et al. 2008 Human reproduction update
18678618 Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Gaulton KJ et al. 2008 Diabetes
18689899 Exchangeable models of complex inherited diseases. Slatkin M et al. 2008 Genetics
18694974 Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. van Hoek M et al. 2008 Diabetes
18707223 PPARG by dietary fat interaction influences bone mass in mice and humans. Ackert-Bicknell CL et al. 2008 Journal of bone and mineral research
18782870 Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008. Florez JC et al. 2008 The Journal of clinical endocrinology and metabolism
18787887 Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures. Tranah GJ et al. 2008 Calcified tissue international
18805939 Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis. Tempfer CB et al. 2009 Human reproduction update
18806092 Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin. Smith CE et al. 2008 The Journal of nutrition
18852197 Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. Mohlke KL et al. 2008 Human molecular genetics
18936436 Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Chang MH et al. 2009 American journal of epidemiology
18959602 The Pro12Ala polymorphism of the PPARG gene is not associated with the metabolic syndrome in an urban population of middle-aged Swedish individuals. Montagnana M et al. 2008 Diabetic medicine
18972257 Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study. Thorsby PM et al. 2009 Scandinavian journal of clinical and laboratory investigation
18992148 Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. Küry S et al. 2008 BMC cancer
18992263 Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. Slattery ML et al. 2009 Mutation research
18996470 Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes. Habalová V et al. 2009 Molecular and cellular probes
19002430 Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population. Cho YM et al. 2009 Diabetologia
19020323 Genotype score in addition to common risk factors for prediction of type 2 diabetes. Meigs JB et al. 2008 The New England journal of medicine
19056611 Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Timpson NJ et al. 2009 Diabetes
19096518 Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study. Paré G et al. 2008 PLoS genetics
19131662 A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Wang X et al. 2009 Stroke
19161620 An open access database of genome-wide association results. Johnson AD et al. 2009 BMC medical genetics
19178525 PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population. Osawa H et al. 2009 Clinical endocrinology
19207020 Meta-analysis in genome-wide association studies. Zeggini E et al. 2009 Pharmacogenomics
19223982 Genetic variability of RXRB, PPARA, and PPARG in Wegener's granulomatosis. Wieczorek S et al. 2009 PPAR research
19228871 PPAR gamma variant influences angiographic outcome and 10-year cardiovascular risk in male symptomatic coronary artery disease patients. Regieli JJ et al. 2009 Diabetes care
19263529 Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. Zee RY et al. 2009 Clinica chimica acta; international journal of clinical chemistry
19279076 Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men. Qi L et al. 2009 The American journal of clinical nutrition
19323962 Genome-wide association studies in type 2 diabetes. McCarthy MI et al. 2009 Current diabetes reports
19324937 Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. Brito EC et al. 2009 Diabetes
19341491 Genome-based prediction of common diseases: methodological considerations for future research. Janssens AC et al. 2009 Genome medicine
19360113 The role of the PGC1α Gly482Ser polymorphism in weight gain due to intensive diabetes therapy. Deeb SS et al. 2009 PPAR research
19401414 Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Takeuchi F et al. 2009 Diabetes
19455305 No association of multiple type 2 diabetes loci with type 1 diabetes. Raj SM et al. 2009 Diabetologia
19460916 Genetic architecture of type 2 diabetes: recent progress and clinical implications. Grant RW et al. 2009 Diabetes care
19502414 Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Stancáková A et al. 2009 Diabetes
19526209 Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants? Southam L et al. 2009 Diabetologia
19543210 PPARG genotype accounts for part of individual variation in body weight reduction in response to calorie restriction. Matsuo T et al. 2009 Obesity (Silver Spring, Md.)
19567509 Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes. Breyer JP et al. 2009 Cancer epidemiology, biomarkers & prevention
19587357 A systematic meta-analysis of genetic association studies for diabetic retinopathy. Abhary S et al. 2009 Diabetes
19602701 Underlying genetic models of inheritance in established type 2 diabetes associations. Salanti G et al. 2009 American journal of epidemiology
19603096 An analysis of growth, differentiation and apoptosis genes with risk of renal cancer. Dong LM et al. 2009 PloS one
19626703 Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies. Yoo YJ et al. 2010 Genetic epidemiology
19634985 Peroxisome proliferator-activated receptor-gamma (PPARgamma) Pro12Ala polymorphism and risk for pediatric obesity. Dedoussis GV et al. 2009 Clinical chemistry and laboratory medicine
19644638 No association between polymorphisms of peroxisome [corrected] proliferator-activated receptor-gamma gene and peak bone mineral density variation in Chinese nuclear families. Yue H et al. 2010 Osteoporosis international
19660836 APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk. Combarros O et al. 2011 Neurobiology of aging
19720797 Impact of the PPAR-gamma2 Pro12Ala polymorphism and ACE inhibitor therapy on new-onset microalbuminuria in type 2 diabetes: evidence from BENEDICT. De Cosmo S et al. 2009 Diabetes
19733160 Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population. Ben Ali S et al. 2009 Clinical biochemistry
19734549 Ranking of genome-wide association scan signals by different measures. Strömberg U et al. 2009 International journal of epidemiology
19745552 Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: interaction with smoking status. Tellechea ML et al. 2009 Circulation journal
19773451 Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Reyes-Gibby CC et al. 2009 Cancer epidemiology, biomarkers & prevention
19794065 Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Lango Allen H et al. 2010 Diabetes
19846176 PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor. Sanghera DK et al. 2010 Metabolism
19862325 PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. Hu C et al. 2009 PloS one
19931040 Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies. Browning BL et al. 2009 American journal of human genetics
19956539 How many genetic variants remain to be discovered? Pawitan Y et al. 2009 PloS one
20017978 Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study. Fradin DD et al. 2009 BMC proceedings
20018041 The effect of multiple genetic variants in predicting the risk of type 2 diabetes. Lu Q et al. 2009 BMC proceedings
20018066 Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study. An P et al. 2009 BMC proceedings
20043145 Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study. Ruchat SM et al. 2010 Diabetologia
20043853 Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus. Parikh H et al. 2009 BMC medical genomics
20049090 Association between type 2 diabetes loci and measures of fatness. Pecioska S et al. 2010 PloS one
20075150 Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. Talmud PJ et al. 2010 BMJ (Clinical research ed.)
20079163 Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population. Wang F et al. 2009 Chinese medical journal
20142250 Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study. Meyer TE et al. 2010 Cancer epidemiology, biomarkers & prevention
20144327 A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel. Lott L et al. 2009 Journal of diabetes science and technology
20161779 Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. Wen J et al. 2010 PloS one
20179158 The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. Gouda HN et al. 2010 American journal of epidemiology
20203524 Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. Pierce BL et al. 2010 Human heredity
20357209 Molecular genetic studies of gene identification for osteoporosis: the 2009 update. Xu XH et al. 2010 Endocrine reviews
20424228 Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Chauhan G et al. 2010 Diabetes
20437058 The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. Hawken SJ et al. 2010 Human genetics
20569235 HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging. Jazwinski SM et al. 2010 Aging cell
20580778 An age-dependent diet-modified effect of the PPARγ Pro12Ala polymorphism in children. Dedoussis GV et al. 2011 Metabolism
20596649 PPARgamma polymorphisms and cancer risk: a meta-analysis involving 32,138 subjects. Xu W et al. 2010 Oncology reports
20631015 The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study. Underwood PC et al. 2010 The Journal of clinical endocrinology and metabolism
20712903 Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. Morgan AR et al. 2010 BMC medical genetics
20805105 Synthetic associations in the context of genome-wide association scan signals. Orozco G et al. 2010 Human molecular genetics
20811626 Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA et al. 2010 PloS one
20816152 Obesity and diabetes genetic variants associated with gestational weight gain. Stuebe AM et al. 2010 American journal of obstetrics and gynecology
20820957 The genetics of insulin resistance: Where's Waldo? Watanabe RM et al. 2010 Current diabetes reports
20825652 Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study. Dongiovanni P et al. 2010 BMC gastroenterology
20862305 Identification of new genetic risk variants for type 2 diabetes. Shu XO et al. 2010 PLoS genetics
20865176 Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups. Waters KM et al. 2010 PLoS genetics
20870969 Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study. Renström F et al. 2011 Diabetes
20886378 Physiologic characterization of type 2 diabetes-related loci. Grarup N et al. 2010 Current diabetes reports
20929593 The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI. Webster RJ et al. 2010 BMC medical genetics
20930717 D2 Thr92Ala and PPARγ2 Pro12Ala polymorphisms interact in the modulation of insulin resistance in type 2 diabetic patients. Estivalet AA et al. 2011 Obesity (Silver Spring, Md.)
20936101 Pharmacogenetics of Anti-Diabetes Drugs. Distefano JK et al. 2010 Pharmaceuticals (Basel, Switzerland)
20980412 Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study. Uusitupa MI et al. 2011 Diabetes care
21044285 Analyses of association between PPAR gamma and EPHX1 polymorphisms and susceptibility to COPD in a Hungarian cohort, a case-control study. Penyige A et al. 2010 BMC medical genetics
21054877 Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994. Ned RM et al. 2010 BMC medical genetics
21058334 MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Li Y et al. 2010 Genetic epidemiology
21084393 Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects. Sharma NK et al. 2011 The Journal of clinical endocrinology and metabolism
21091714 The genetics of type 2 diabetes: what have we learned from GWAS? Billings LK et al. 2010 Annals of the New York Academy of Sciences
21103332 Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies. Xu M et al. 2010 PloS one
21124985 Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. Bell CG et al. 2010 PloS one
21127830 Genetic associations in diabetic nephropathy: a meta-analysis. Mooyaart AL et al. 2011 Diabetologia
21133856 Genome-wide association scan allowing for epistasis in type 2 diabetes. Bell JT et al. 2011 Annals of human genetics
21146954 Genes and abdominal aortic aneurysm. Hinterseher I et al. 2011 Annals of vascular surgery
21150882 Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia. Karns R et al. 2011 European journal of human genetics
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29055064 Clinical relevance of peroxisome proliferator-activated receptor-γ gene polymorphisms with sepsis. Liu Y et al. 2018 Journal of clinical laboratory analysis
29200867 The relationship between <i>IGF2BP2</i> and <i>PPARG</i> polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population. Qiu H et al. 2017 OncoTargets and therapy
29246001 Association of <i>PPARG</i> rs 1801282 C&gt;G polymorphism with risk of colorectal cancer: from a case-control study to a meta-analysis. Jiang J et al. 2017 Oncotarget
29256014 Genetic variation in TNFα, PPARγ, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort. Duggan C et al. 2018 Breast cancer research and treatment
29273888 Identification of pleiotropic genetic variants affecting osteoporosis risk in a Korean elderly cohort. Hong EP et al. 2019 Journal of bone and mineral metabolism
29303622 Genotype-based recall to study metabolic effects of genetic variation: a pilot study of PPARG Pro12Ala carriers. Kamble PG et al. 2017 Upsala journal of medical sciences
29315078 Associations between the components of metabolic syndrome and the polymorphisms in the peroxisome proliferator-activated receptor gamma (<i>PPAR-γ</i>), the fat mass and obesity-associated (<i>FTO</i>), and the melanocortin-4 receptor (<i>MC4R</i>) genes. Szkup M et al. 2018 Aging
29325775 Nutrigenetic variants and cardio-metabolic risk in women with or without gestational diabetes. Franzago M et al. 2018 Diabetes research and clinical practice
29369552 [Association of variable rs1801282 locus of PPARG2 gene with diabetic nephropathy]. Avzaletdinova DS et al. 2016 Genetika
29402778 Interaction of Vitamin E Intake and Pro12Ala Polymorphism of PPARG with Adiponectin Levels. Campos-Perez W et al. 2017 Journal of nutrigenetics and nutrigenomics
29494521 Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men. Nishida Y et al. 2018 International journal of molecular sciences
29496354 Expression of the gene coading for PGC-1α in peripheral blood leukocytes and related gene variants in patients with Parkinson's disease. Yang XD et al. 2018 Parkinsonism & related disorders
29610599 Is the rs1801282 (G/C) Polymorphism of <i>PPAR - Gamma</i> Gene Associated with T2DM in Iraqi People? Al-Naemi AH et al. 2018 Open access Macedonian journal of medical sciences
29665413 Genetic risk factors for post-transplantation diabetes mellitus in Chinese Han renal allograft recipients treated with tacrolimus. Zhang X et al. 2018 Transplant immunology
29679223 Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children. Almeida SM et al. 2018 Endocrine
29703528 Replication of a Gene-Diet Interaction at CD36, NOS3 and PPARG in Response to Omega-3 Fatty Acid Supplements on Blood Lipids: A Double-Blind Randomized Controlled Trial. Zheng JS et al. 2018 EBioMedicine
29762540 The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review. Petr M et al. 2018 International journal of molecular sciences
29795275 Phenotype and genotype predictors of BMI variability among European adults. Goni L et al. 2018 Nutrition & diabetes
29800730 The ADRA2A rs553668 variant is associated with type 2 diabetes and five variants were associated at nominal significance levels in a population-based case-control study from Mexico City. Totomoch-Serra A et al. 2018 Gene
29885389 Geographic diversity in genotype frequencies and meta-analysis of the association between rs1801282 polymorphisms and gestational diabetes mellitus. Lin PC et al. 2018 Diabetes research and clinical practice
29970681 Peroxisome proliferators-activated receptor gamma polymorphisms and colorectal cancer risk. Liang X et al. 2018 Journal of cancer research and therapeutics
29972410 Genetic Risk Analysis of Coronary Artery Disease in a Population-based Study in Portugal, Using a Genetic Risk Score of 31 Variants. Pereira A et al. 2018 Arquivos brasileiros de cardiologia
30026785 <i>PPARG2</i> Pro12Ala polymorphism influences body composition changes in severely obese patients consuming extra virgin olive oil: a randomized clinical trial. Rodrigues APS et al. 2018 Nutrition & metabolism
30041843 Genetic susceptibility to pre diabetes mellitus and related association with obesity and physical fitness components in Mexican-Mestizos. Costa-Urrutia P et al. 2018 Primary care diabetes
30122956 Relationship of <i>PPARG</i>, <i>PPARGC1A</i>, and <i>PPARGC1B</i> polymorphisms with susceptibility to hepatocellular carcinoma in an eastern Chinese Han population. Zhang S et al. 2018 OncoTargets and therapy
30182779 Genetic susceptibility to cerebrovascular disease: A systematic review. Griessenauer CJ et al. 2018 Journal of cerebral blood flow and metabolism
30337837 Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis. Wen J et al. 2018 Cancer cell international
30489355 Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk. Kim NH et al. 2019 European journal of cancer prevention
30571812 Additional value of a combined genetic risk score to standard cardiovascular stratification. Pereira A et al. 2018 Genetics and molecular biology
30584432 Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study. Daneshpour MS et al. 2018 International journal of endocrinology and metabolism
30607268 Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents. Martínez-Martínez MD et al. 2018 Sultan Qaboos University medical journal
30647679 Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus. Hasan NS et al. 2017 Journal, genetic engineering & biotechnology
30652031 The Single Nucleotide Polymorphism <i>PPARG2</i> Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients. Rodrigues APDS et al. 2018 Journal of obesity
31044373 Targeted sequencing analysis of PPARG identifies a risk variant associated with obstructive sleep apnea in Chinese Han subjects. Jiao X et al. 2020 Sleep & breathing = Schlaf & Atmung
31074700 <i>PPARG</i> Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training. Blond MB et al. 2019 Physiological genomics
31188078 PPARγ Pro12Ala Polymorphism Influences the Relationship between Dietary Fat Intake, Adiposity and Lipid Profile in Patients with Type 2 Diabetes. Koohdani F et al. 2018 International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
31231424 Genetic and Epigenetic Studies in Diabetic Kidney Disease. Gu HF et al. 2019 Frontiers in genetics
31252163 PPARA, PPARD and PPARG gene polymorphisms in patients with unstable angina. Maciejewska-Skrendo A et al. 2019 Gene
31290457 Association between <i>PPARG</i> genetic polymorphisms and ischemic stroke risk in a northern Chinese Han population: a case-control study. Wang YZ et al. 2019 Neural regeneration research
31412346 Associations of Leptin Receptor and Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis. Liang J et al. 2019 Annals of nutrition & metabolism
31516756 Genetic polymorphisms and gastric cancer risk: a comprehensive review synopsis from meta-analysis and genome-wide association studies. Tian J et al. 2019 Cancer biology & medicine
31675538 PPARG and FTO polymorphism can modulate the outcomes of a central European diet and a Mediterranean diet in centrally obese postmenopausal women. Chmurzynska A et al. 2019 Nutrition research (New York, N.Y.)
31821471 Polymorphisms and endometriosis: a systematic review and meta-analyses. Méar L et al. 2020 Human reproduction update
31881714 Association of Elite Sports Status with Gene Variants of Peroxisome Proliferator Activated Receptors and Their Transcriptional Coactivator. Petr M et al. 2019 International journal of molecular sciences
31915541 PPARG Polymorphisms Are Associated with Unexplained Mild Vision Loss in Patients with Type 2 Diabetes Mellitus. Li T et al. 2019 Journal of ophthalmology
31947684 The Effect Sizes of <i>PPARγ</i> rs1801282<i>, FTO</i> rs9939609, and <i>MC4R</i> rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study. Bakhashab S et al. 2020 Genes
32064572 Computational determination of human PPARG gene: SNPs and prediction of their effect on protein functions of diabetic patients. Mustafa HA et al. 2020 Clinical and translational medicine
32323264 Association of the polymorphisms of the genes APOC3 (rs2854116), ESR2 (rs3020450), HFE (rs1799945), MMP1 (rs1799750) and PPARG (rs1801282) with lipodystrophy in people living with HIV on antiretroviral therapy: a systematic review. da Silva AS et al. 2020 Molecular biology reports
32326111 Role of Genetic Variations in the Hepatic Handling of Drugs. Marin JJG et al. 2020 International journal of molecular sciences
32384785 Applicability of Obesity-Related SNPs and their Effect Size Measures Defined on Populations with European Ancestry for Genetic Risk Estimation among Roma. Llanaj E et al. 2020 Genes
32416637 Biochemical investigation of rs1801282 variations in PPAR-γ gene and its correlation with risk factors of diabetes mellitus in coronary artery disease. Rehman K et al. 2020 Clinical and experimental pharmacology & physiology
32417009 Association between PPARγrs1801282 polymorphism with diabetic nephropathy and type-2 diabetes mellitus susceptibility in south India and a meta-analysis. Regine I et al. 2020 Nefrologia
32419081 Polymorphisms of the genes CTLA4, PTPN22, CD40, and PPARG and their roles in Graves' disease: susceptibility and clinical features. Bufalo NE et al. 2021 Endocrine
32713352 Does polymorphisms in <i>PPAR</i> and <i>APOE</i> genes modify associations between fatty acid desaturase (<i>FADS</i>), <i>n</i>-3 long-chain PUFA and cardiometabolic markers in 8-11-year-old Danish children? Damsgaard CT et al. 2021 The British journal of nutrition
32728045 PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis. Sarhangi N et al. 2020 Scientific reports
32755657 Associations between peroxisome proliferator-activated receptor γ (PPAR-γ) polymorphisms and serum lipids: Two cross-sectional studies of community-dwelling adults. Matsunaga T et al. 2020 Gene
32930968 Pharmacogenomic Studies of Current Antidiabetic Agents and Potential New Drug Targets for Precision Medicine of Diabetes. Zeng Z et al. 2020 Diabetes therapy
32955223 Seeking genetic determinants of selected metabolic disorders in women aged 45-60. Szkup M et al. 2020 Annals of agricultural and environmental medicine
33192589 No Change - No Gain; The Effect of Age, Sex, Selected Genes and Training on Physiological and Performance Adaptations in Cross-Country Skiing. Johansen JM et al. 2020 Frontiers in physiology
33250050 Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring. García-Ricobaraza M et al. 2020 Journal of biomedical science
33262486 Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters. 2020 European journal of human genetics
33477496 Diet and <i>PPARG2</i> Pro12Ala Polymorphism Interactions in Relation to Cancer Risk: A Systematic Review. Tran L et al. 2021 Nutrients
33535175 Association between <i>PPAR-γ2</i> gene polymorphisms and diabetic retinopathy risk: a meta-analysis. Li XF et al. 2021 Aging
33729310 Effects of FTO and PPARγ variants on intrauterine growth restriction in a Brazilian birth cohort. Barbieri MR et al. 2021 Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post596+ae089ad