dbSNP Short Genetic Variations
Welcome to the Reference SNP (rs) Report
All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.
Reference SNP (rs) Report
This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.
rs1800629
Current Build 154
Released April 21, 2020
- Organism
- Homo sapiens
- Position
-
chr6:31575254 (GRCh38.p12) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
- Alleles
- G>A
- Variation Type
- SNV Single Nucleotide Variation
- Frequency
-
A=0.116335 (17554/150892, GnomAD_exome)A=0.143142 (17974/125568, TOPMED)A=0.155316 (16999/109448, ALFA Project) (+ 19 more)
- Clinical Significance
- Reported in ClinVar
- Gene : Consequence
- TNF : 2KB Upstream Variant
- Publications
- 633 citations
- Genomic View
- See rs on genome
Help
Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.
Genomic Placements
| Sequence name | Change |
|---|---|
| GRCh38.p12 chr 6 | NC_000006.12:g.31575254G>A |
| GRCh37.p13 chr 6 | NC_000006.11:g.31543031G>A |
| TNF RefSeqGene | NG_007462.1:g.4682G>A |
| LTA RefSeqGene | NG_012010.1:g.8156G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_COX_CTG1 | NT_113891.3:g.3052541A>G |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_COX_CTG1 | NT_113891.2:g.3052647A>G |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_MANN_CTG1 | NT_167246.2:g.2880295G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MANN_CTG1 | NT_167246.1:g.2885915G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1 | NT_167249.2:g.2874534G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1 | NT_167249.1:g.2873832G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_QBL_CTG1 | NT_167248.2:g.2831073G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_QBL_CTG1 | NT_167248.1:g.2836669G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_DBB_CTG1 | NT_167245.2:g.2822987G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_DBB_CTG1 | NT_167245.1:g.2828572G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_MCF_CTG1 | NT_167247.2:g.2917152G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MCF_CTG1 | NT_167247.1:g.2922737G>A |
Gene: TNF, tumor necrosis factor
(plus strand)
:
2KB Upstream Variant
| Molecule type | Change | Amino acid[Codon] | SO Term |
|---|---|---|---|
| TNF transcript | NM_000594.4:c. | N/A | Upstream Transcript Variant |
Help
Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.
Allele: A (allele ID:
227757
)
| ClinVar Accession | Disease Names | Clinical Significance |
|---|---|---|
| RCV000211242.1 | etanercept response - Efficacy | Drug-Response |
| RCV000211284.1 | infliximab response - Efficacy | Drug-Response |
| RCV000211408.1 | Tumor necrosis factor alpha (TNF-alpha) inhibitors response - Efficacy | Drug-Response |
| RCV000211419.1 | adalimumab response - Efficacy | Drug-Response |
ALFA Allele Frequency (New)
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.
Release Version: 20201027095038
| Population | Group | Sample Size | Ref Allele | Alt Allele |
|---|---|---|---|---|
| Total | Global | 260274 | G=0.847933 | A=0.152067 |
| European | Sub | 223476 | G=0.840730 | A=0.159270 |
| African | Sub | 9072 | G=0.8761 | A=0.1239 |
| African Others | Sub | 312 | G=0.881 | A=0.119 |
| African American | Sub | 8760 | G=0.8759 | A=0.1241 |
| Asian | Sub | 6664 | G=0.9275 | A=0.0725 |
| East Asian | Sub | 4806 | G=0.9247 | A=0.0753 |
| Other Asian | Sub | 1858 | G=0.9349 | A=0.0651 |
| Latin American 1 | Sub | 584 | G=0.875 | A=0.125 |
| Latin American 2 | Sub | 5366 | G=0.9152 | A=0.0848 |
| South Asian | Sub | 324 | G=0.907 | A=0.093 |
| Other | Sub | 14788 | G=0.87686 | A=0.12314 |
Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").
Download| Study | Population | Group | Sample Size | Ref Allele | Alt Allele |
|---|---|---|---|---|---|
| gnomAD - Exomes | Global | Study-wide | 150892 | G=0.883665 | A=0.116335 |
| gnomAD - Exomes | European | Sub | 69496 | G=0.84058 | A=0.15942 |
| gnomAD - Exomes | Asian | Sub | 34862 | G=0.91937 | A=0.08063 |
| gnomAD - Exomes | American | Sub | 25616 | G=0.94058 | A=0.05942 |
| gnomAD - Exomes | Ashkenazi Jewish | Sub | 8522 | G=0.9238 | A=0.0762 |
| gnomAD - Exomes | African | Sub | 7930 | G=0.8815 | A=0.1185 |
| gnomAD - Exomes | Other | Sub | 4466 | G=0.8762 | A=0.1238 |
| TopMed | Global | Study-wide | 125568 | G=0.856858 | A=0.143142 |
| ALFA | Total | Global | 109448 | G=0.844684 | A=0.155316 |
| ALFA | European | Sub | 93626 | G=0.83763 | A=0.16237 |
| ALFA | Other | Sub | 6882 | G=0.8714 | A=0.1286 |
| ALFA | African | Sub | 4618 | G=0.8826 | A=0.1174 |
| ALFA | Latin American 2 | Sub | 4156 | G=0.9141 | A=0.0859 |
| ALFA | Latin American 1 | Sub | 82 | G=0.89 | A=0.11 |
| ALFA | Asian | Sub | 80 | G=0.95 | A=0.05 |
| ALFA | South Asian | Sub | 4 | G=1.0 | A=0.0 |
| The PAGE Study | Global | Study-wide | 78698 | G=0.90326 | A=0.09674 |
| The PAGE Study | AfricanAmerican | Sub | 32516 | G=0.87249 | A=0.12751 |
| The PAGE Study | Mexican | Sub | 10808 | G=0.93338 | A=0.06662 |
| The PAGE Study | Asian | Sub | 8316 | G=0.9756 | A=0.0244 |
| The PAGE Study | PuertoRican | Sub | 7918 | G=0.9057 | A=0.0943 |
| The PAGE Study | NativeHawaiian | Sub | 4534 | G=0.9285 | A=0.0715 |
| The PAGE Study | Cuban | Sub | 4230 | G=0.8823 | A=0.1177 |
| The PAGE Study | Dominican | Sub | 3828 | G=0.8824 | A=0.1176 |
| The PAGE Study | CentralAmerican | Sub | 2450 | G=0.9327 | A=0.0673 |
| The PAGE Study | SouthAmerican | Sub | 1982 | G=0.9289 | A=0.0711 |
| The PAGE Study | NativeAmerican | Sub | 1260 | G=0.8754 | A=0.1246 |
| The PAGE Study | SouthAsian | Sub | 856 | G=0.928 | A=0.072 |
| gnomAD - Genomes | Global | Study-wide | 31362 | G=0.85317 | A=0.14683 |
| gnomAD - Genomes | European | Sub | 18886 | G=0.83623 | A=0.16377 |
| gnomAD - Genomes | African | Sub | 8704 | G=0.8743 | A=0.1257 |
| gnomAD - Genomes | East Asian | Sub | 1550 | G=0.9110 | A=0.0890 |
| gnomAD - Genomes | Other | Sub | 1084 | G=0.8321 | A=0.1679 |
| gnomAD - Genomes | American | Sub | 848 | G=0.921 | A=0.079 |
| gnomAD - Genomes | Ashkenazi Jewish | Sub | 290 | G=0.893 | A=0.107 |
| ExAC | Global | Study-wide | 20094 | G=0.83841 | A=0.16159 |
| ExAC | Europe | Sub | 9500 | G=0.7780 | A=0.2220 |
| ExAC | Asian | Sub | 8566 | G=0.9075 | A=0.0925 |
| ExAC | African | Sub | 1294 | G=0.8060 | A=0.1940 |
| ExAC | American | Sub | 554 | G=0.868 | A=0.132 |
| ExAC | Other | Sub | 180 | G=0.878 | A=0.122 |
| GO Exome Sequencing Project | Global | Study-wide | 5678 | G=0.8586 | A=0.1414 |
| GO Exome Sequencing Project | European American | Sub | 3944 | G=0.8494 | A=0.1506 |
| GO Exome Sequencing Project | African American | Sub | 1734 | G=0.8795 | A=0.1205 |
| 1000Genomes | Global | Study-wide | 5008 | G=0.9097 | A=0.0903 |
| 1000Genomes | African | Sub | 1322 | G=0.8805 | A=0.1195 |
| 1000Genomes | East Asian | Sub | 1008 | G=0.9415 | A=0.0585 |
| 1000Genomes | Europe | Sub | 1006 | G=0.8658 | A=0.1342 |
| 1000Genomes | South Asian | Sub | 978 | G=0.947 | A=0.053 |
| 1000Genomes | American | Sub | 694 | G=0.931 | A=0.069 |
| Genetic variation in the Estonian population | Estonian | Study-wide | 4480 | G=0.8328 | A=0.1672 |
| The Avon Longitudinal Study of Parents and Children | PARENT AND CHILD COHORT | Study-wide | 3854 | G=0.8028 | A=0.1972 |
| UK 10K study - Twins | TWIN COHORT | Study-wide | 3708 | G=0.8045 | A=0.1955 |
| KOREAN population from KRGDB | KOREAN | Study-wide | 2930 | G=0.9280 | A=0.0720 |
| HapMap | Global | Study-wide | 1892 | G=0.9149 | A=0.0851 |
| HapMap | American | Sub | 770 | G=0.912 | A=0.088 |
| HapMap | African | Sub | 692 | G=0.913 | A=0.087 |
| HapMap | Asian | Sub | 254 | G=0.937 | A=0.063 |
| HapMap | Europe | Sub | 176 | G=0.903 | A=0.097 |
| Genome of the Netherlands Release 5 | Genome of the Netherlands | Study-wide | 998 | G=0.808 | A=0.192 |
| PharmGKB Aggregated | Global | Study-wide | 946 | G=0.893 | A=0.107 |
| PharmGKB Aggregated | PA135299591 | Sub | 946 | G=0.893 | A=0.107 |
| Northern Sweden | ACPOP | Study-wide | 600 | G=0.825 | A=0.175 |
| Medical Genome Project healthy controls from Spanish population | Spanish controls | Study-wide | 534 | G=0.890 | A=0.110 |
| Qatari | Global | Study-wide | 216 | G=0.787 | A=0.213 |
| SGDP_PRJ | Global | Study-wide | 68 | G=0.41 | A=0.59 |
| The Danish reference pan genome | Danish | Study-wide | 40 | G=0.82 | A=0.17 |
| Siberian | Global | Study-wide | 8 | G=0.5 | A=0.5 |
Help
Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".
| Placement | G= | A |
|---|---|---|
| GRCh38.p12 chr 6 | NC_000006.12:g.31575254= | NC_000006.12:g.31575254G>A |
| GRCh37.p13 chr 6 | NC_000006.11:g.31543031= | NC_000006.11:g.31543031G>A |
| TNF RefSeqGene | NG_007462.1:g.4682= | NG_007462.1:g.4682G>A |
| LTA RefSeqGene | NG_012010.1:g.8156= | NG_012010.1:g.8156G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_COX_CTG1 | NT_113891.3:g.3052541A>G | NT_113891.3:g.3052541= |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_COX_CTG1 | NT_113891.2:g.3052647A>G | NT_113891.2:g.3052647= |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_MANN_CTG1 | NT_167246.2:g.2880295= | NT_167246.2:g.2880295G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MANN_CTG1 | NT_167246.1:g.2885915= | NT_167246.1:g.2885915G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1 | NT_167249.2:g.2874534= | NT_167249.2:g.2874534G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1 | NT_167249.1:g.2873832= | NT_167249.1:g.2873832G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_QBL_CTG1 | NT_167248.2:g.2831073= | NT_167248.2:g.2831073G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_QBL_CTG1 | NT_167248.1:g.2836669= | NT_167248.1:g.2836669G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_DBB_CTG1 | NT_167245.2:g.2822987= | NT_167245.2:g.2822987G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_DBB_CTG1 | NT_167245.1:g.2828572= | NT_167245.1:g.2828572G>A |
| GRCh38.p12 chr 6 alt locus HSCHR6_MHC_MCF_CTG1 | NT_167247.2:g.2917152= | NT_167247.2:g.2917152G>A |
| GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MCF_CTG1 | NT_167247.1:g.2922737= | NT_167247.1:g.2922737G>A |
Help
Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.
130 SubSNP,
21 Frequency,
4 ClinVar
submissions
| No | Submitter | Submission ID | Date (Build) |
|---|---|---|---|
| 1 | HGBASE | ss2420741 | Nov 14, 2000 (89) |
| 2 | PGA-UW-FHCRC | ss4328930 | Mar 26, 2002 (106) |
| 3 | SC_JCM | ss4377317 | Mar 26, 2002 (106) |
| 4 | SNP500CANCER | ss5586943 | Jul 02, 2003 (116) |
| 5 | EGP_SNPS | ss6310583 | Feb 20, 2003 (111) |
| 6 | EGP_SNPS | ss6312900 | Feb 20, 2003 (111) |
| 7 | SI_MHC_SNP | ss12691494 | Oct 31, 2003 (118) |
| 8 | FHCRC | ss16360688 | Feb 27, 2004 (120) |
| 9 | FHCRC | ss16360736 | Feb 27, 2004 (120) |
| 10 | STEJUSTINE-REGGEN | ss51854703 | Mar 16, 2006 (126) |
| 11 | PGA-UW-FHCRC | ss52088979 | Oct 15, 2006 (127) |
| 12 | KRIBB_YJKIM | ss65843449 | Nov 30, 2006 (127) |
| 13 | EGP_SNPS | ss66857511 | Nov 30, 2006 (127) |
| 14 | EGP_SNPS | ss66859809 | Nov 30, 2006 (127) |
| 15 | PERLEGEN | ss68971678 | May 17, 2007 (127) |
| 16 | PHARMGKB_PARC | ss69366252 | May 17, 2007 (127) |
| 17 | ILLUMINA | ss75254821 | Dec 07, 2007 (129) |
| 18 | CGM_KYOTO | ss76873614 | Dec 07, 2007 (129) |
| 19 | HGSV | ss80949408 | Dec 15, 2007 (130) |
| 20 | HURLEY-POSCH-LAB | ss86217651 | Mar 23, 2008 (129) |
| 21 | SHGC | ss95216268 | Feb 05, 2009 (130) |
| 22 | BGI | ss104296823 | Dec 01, 2009 (131) |
| 23 | 1000GENOMES | ss109901711 | Feb 13, 2009 (130) |
| 24 | ILLUMINA-UK | ss116394700 | Feb 14, 2009 (130) |
| 25 | GMI | ss156747688 | Dec 01, 2009 (131) |
| 26 | ILLUMINA | ss160462872 | Dec 01, 2009 (131) |
| 27 | COMPLETE_GENOMICS | ss162198777 | Jul 04, 2010 (132) |
| 28 | ILLUMINA | ss172924883 | Jul 04, 2010 (132) |
| 29 | BUSHMAN | ss201626002 | Jul 04, 2010 (132) |
| 30 | 1000GENOMES | ss222304163 | Jul 14, 2010 (132) |
| 31 | 1000GENOMES | ss233399218 | Jul 14, 2010 (132) |
| 32 | 1000GENOMES | ss240469923 | Jul 15, 2010 (132) |
| 33 | ILLUMINA | ss244285039 | Jul 04, 2010 (132) |
| 34 | BL | ss254187389 | May 09, 2011 (137) |
| 35 | GMI | ss278727093 | May 04, 2012 (137) |
| 36 | GMI | ss285374156 | Apr 25, 2013 (138) |
| 37 | ILLUMINA | ss410916050 | Sep 17, 2011 (137) |
| 38 | ILLUMINA | ss480300551 | May 04, 2012 (137) |
| 39 | ILLUMINA | ss480311656 | May 04, 2012 (137) |
| 40 | ILLUMINA | ss481067278 | Sep 08, 2015 (146) |
| 41 | ILLUMINA | ss484948088 | May 04, 2012 (137) |
| 42 | EXOME_CHIP | ss491381906 | May 04, 2012 (137) |
| 43 | ILLUMINA | ss536992328 | Sep 08, 2015 (146) |
| 44 | SSMP | ss653035581 | Apr 25, 2013 (138) |
| 45 | NHLBI-ESP | ss712699264 | Apr 25, 2013 (138) |
| 46 | ILLUMINA | ss778467783 | Sep 08, 2015 (146) |
| 47 | ILLUMINA | ss780682574 | Sep 08, 2015 (146) |
| 48 | ILLUMINA | ss782920352 | Sep 08, 2015 (146) |
| 49 | ILLUMINA | ss783355928 | Sep 08, 2015 (146) |
| 50 | ILLUMINA | ss783883384 | Sep 08, 2015 (146) |
| 51 | ILLUMINA | ss832175477 | Sep 08, 2015 (146) |
| 52 | ILLUMINA | ss833923542 | Sep 08, 2015 (146) |
| 53 | JMKIDD_LAB | ss974459603 | Aug 21, 2014 (142) |
| 54 | EVA-GONL | ss982766421 | Aug 21, 2014 (142) |
| 55 | JMKIDD_LAB | ss1067477166 | Aug 21, 2014 (142) |
| 56 | JMKIDD_LAB | ss1073506038 | Aug 21, 2014 (142) |
| 57 | 1000GENOMES | ss1319558829 | Aug 21, 2014 (142) |
| 58 | EVA_GENOME_DK | ss1581606820 | Apr 01, 2015 (144) |
| 59 | EVA_DECODE | ss1592310303 | Apr 01, 2015 (144) |
| 60 | EVA_UK10K_ALSPAC | ss1615278019 | Apr 01, 2015 (144) |
| 61 | EVA_UK10K_TWINSUK | ss1658272052 | Apr 01, 2015 (144) |
| 62 | EVA_EXAC | ss1688230716 | Apr 01, 2015 (144) |
| 63 | EVA_MGP | ss1711121135 | Apr 01, 2015 (144) |
| 64 | EVA_SVP | ss1712851078 | Apr 01, 2015 (144) |
| 65 | ILLUMINA | ss1752628691 | Sep 08, 2015 (146) |
| 66 | ILLUMINA | ss1752628692 | Sep 08, 2015 (146) |
| 67 | ILLUMINA | ss1917802451 | Feb 12, 2016 (147) |
| 68 | WEILL_CORNELL_DGM | ss1926018780 | Feb 12, 2016 (147) |
| 69 | ILLUMINA | ss1946173378 | Feb 12, 2016 (147) |
| 70 | ILLUMINA | ss1958888381 | Feb 12, 2016 (147) |
| 71 | JJLAB | ss2023642576 | Sep 14, 2016 (149) |
| 72 | ILLUMINA | ss2094824801 | Dec 20, 2016 (150) |
| 73 | ILLUMINA | ss2095178036 | Dec 20, 2016 (150) |
| 74 | USC_VALOUEV | ss2151809013 | Dec 20, 2016 (150) |
| 75 | HUMAN_LONGEVITY | ss2282946228 | Dec 20, 2016 (150) |
| 76 | TOPMED | ss2451321803 | Dec 20, 2016 (150) |
| 77 | SYSTEMSBIOZJU | ss2626308723 | Nov 08, 2017 (151) |
| 78 | ILLUMINA | ss2634429968 | Nov 08, 2017 (151) |
| 79 | ILLUMINA | ss2635155642 | Nov 08, 2017 (151) |
| 80 | GRF | ss2707402813 | Nov 08, 2017 (151) |
| 81 | ILLUMINA | ss2711069578 | Nov 08, 2017 (151) |
| 82 | GNOMAD | ss2735648837 | Nov 08, 2017 (151) |
| 83 | GNOMAD | ss2747581793 | Nov 08, 2017 (151) |
| 84 | GNOMAD | ss2837428886 | Nov 08, 2017 (151) |
| 85 | AFFY | ss2985362252 | Nov 08, 2017 (151) |
| 86 | AFFY | ss2985994164 | Nov 08, 2017 (151) |
| 87 | SWEGEN | ss2998796491 | Nov 08, 2017 (151) |
| 88 | ILLUMINA | ss3022599572 | Nov 08, 2017 (151) |
| 89 | BIOINF_KMB_FNS_UNIBA | ss3025608431 | Nov 08, 2017 (151) |
| 90 | TOPMED | ss3493847195 | Nov 08, 2017 (151) |
| 91 | ILLUMINA | ss3625897843 | Oct 12, 2018 (152) |
| 92 | ILLUMINA | ss3629503652 | Oct 12, 2018 (152) |
| 93 | ILLUMINA | ss3629503653 | Oct 12, 2018 (152) |
| 94 | ILLUMINA | ss3632348527 | Oct 12, 2018 (152) |
| 95 | ILLUMINA | ss3633415350 | Oct 12, 2018 (152) |
| 96 | ILLUMINA | ss3634137836 | Oct 12, 2018 (152) |
| 97 | ILLUMINA | ss3635057013 | Oct 12, 2018 (152) |
| 98 | ILLUMINA | ss3635057014 | Oct 12, 2018 (152) |
| 99 | ILLUMINA | ss3635818854 | Oct 12, 2018 (152) |
| 100 | ILLUMINA | ss3636778275 | Oct 12, 2018 (152) |
| 101 | ILLUMINA | ss3637571638 | Oct 12, 2018 (152) |
| 102 | ILLUMINA | ss3638619862 | Oct 12, 2018 (152) |
| 103 | ILLUMINA | ss3640764312 | Oct 12, 2018 (152) |
| 104 | ILLUMINA | ss3640764313 | Oct 12, 2018 (152) |
| 105 | ILLUMINA | ss3643561243 | Oct 12, 2018 (152) |
| 106 | ILLUMINA | ss3644906437 | Oct 12, 2018 (152) |
| 107 | OMUKHERJEE_ADBS | ss3646334755 | Oct 12, 2018 (152) |
| 108 | ILLUMINA | ss3653112183 | Oct 12, 2018 (152) |
| 109 | ILLUMINA | ss3653112184 | Oct 12, 2018 (152) |
| 110 | ILLUMINA | ss3654128111 | Oct 12, 2018 (152) |
| 111 | KU-SAB | ss3654261673 | Oct 12, 2018 (152) |
| 112 | EGCUT_WGS | ss3666710812 | Jul 13, 2019 (153) |
| 113 | EVA_DECODE | ss3716909250 | Jul 13, 2019 (153) |
| 114 | ILLUMINA | ss3726330083 | Jul 13, 2019 (153) |
| 115 | ACPOP | ss3733362133 | Jul 13, 2019 (153) |
| 116 | ILLUMINA | ss3744549890 | Jul 13, 2019 (153) |
| 117 | ILLUMINA | ss3745357013 | Jul 13, 2019 (153) |
| 118 | ILLUMINA | ss3745357014 | Jul 13, 2019 (153) |
| 119 | EVA | ss3764822995 | Jul 13, 2019 (153) |
| 120 | PAGE_CC | ss3771278957 | Jul 13, 2019 (153) |
| 121 | ILLUMINA | ss3772850714 | Jul 13, 2019 (153) |
| 122 | ILLUMINA | ss3772850715 | Jul 13, 2019 (153) |
| 123 | KHV_HUMAN_GENOMES | ss3807978245 | Jul 13, 2019 (153) |
| 124 | EVA | ss3824170220 | Apr 26, 2020 (154) |
| 125 | EVA | ss3825694226 | Apr 26, 2020 (154) |
| 126 | EVA | ss3829833058 | Apr 26, 2020 (154) |
| 127 | EVA | ss3838394885 | Apr 26, 2020 (154) |
| 128 | EVA | ss3843837070 | Apr 26, 2020 (154) |
| 129 | SGDP_PRJ | ss3864255581 | Apr 26, 2020 (154) |
| 130 | KRGDB | ss3911030497 | Apr 26, 2020 (154) |
| 131 | 1000Genomes | NC_000006.11 - 31543031 | Oct 12, 2018 (152) |
| 132 | The Avon Longitudinal Study of Parents and Children | NC_000006.11 - 31543031 | Oct 12, 2018 (152) |
| 133 | Genetic variation in the Estonian population | NC_000006.11 - 31543031 | Oct 12, 2018 (152) |
| 134 | ExAC | NC_000006.11 - 31543031 | Oct 12, 2018 (152) |
| 135 | The Danish reference pan genome | NC_000006.11 - 31543031 | Apr 26, 2020 (154) |
| 136 | gnomAD - Genomes | NC_000006.11 - 31543031 | Jul 13, 2019 (153) |
| 137 | gnomAD - Exomes | NC_000006.11 - 31543031 | Jul 13, 2019 (153) |
| 138 | GO Exome Sequencing Project | NC_000006.11 - 31543031 | Oct 12, 2018 (152) |
| 139 | Genome of the Netherlands Release 5 | NC_000006.11 - 31543031 | Apr 26, 2020 (154) |
| 140 | HapMap | NC_000006.12 - 31575254 | Apr 26, 2020 (154) |
| 141 | KOREAN population from KRGDB | NC_000006.11 - 31543031 | Apr 26, 2020 (154) |
| 142 | Medical Genome Project healthy controls from Spanish population | NC_000006.11 - 31543031 | Apr 26, 2020 (154) |
| 143 | Northern Sweden | NC_000006.11 - 31543031 | Jul 13, 2019 (153) |
| 144 | The PAGE Study | NC_000006.12 - 31575254 | Jul 13, 2019 (153) |
| 145 | PharmGKB Aggregated | NC_000006.12 - 31575254 | Apr 26, 2020 (154) |
| 146 | Qatari | NC_000006.11 - 31543031 | Apr 26, 2020 (154) |
| 147 | SGDP_PRJ | NC_000006.11 - 31543031 | Apr 26, 2020 (154) |
| 148 | Siberian | NC_000006.11 - 31543031 | Apr 26, 2020 (154) |
| 149 | TopMed | NC_000006.12 - 31575254 | Oct 12, 2018 (152) |
| 150 | UK 10K study - Twins | NC_000006.11 - 31543031 | Oct 12, 2018 (152) |
| 151 | dbGaP Population Frequency Project | NC_000006.12 - 31575254 | Apr 26, 2020 (154) |
| 152 | ClinVar | RCV000211242.1 | Oct 12, 2018 (152) |
| 153 | ClinVar | RCV000211284.1 | Oct 12, 2018 (152) |
| 154 | ClinVar | RCV000211408.1 | Oct 12, 2018 (152) |
| 155 | ClinVar | RCV000211419.1 | Oct 12, 2018 (152) |
Help
History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).
| Associated ID | History Updated (Build) |
|---|---|
| rs3091256 | Jul 03, 2002 (106) |
| rs4134777 | Nov 14, 2002 (109) |
| rs36205298 | Oct 25, 2006 (127) |
| rs59729336 | May 25, 2008 (130) |
| rs116610137 | Oct 26, 2010 (133) |
| rs117441802 | Aug 16, 2010 (132) |
| rs148958203 | May 04, 2012 (137) |
Added to this RefSNP Cluster:
| Submission IDs | Observation SPDI | Canonical SPDI | Source RSIDs |
|---|---|---|---|
| ss80949408 | NC_000006.9:31651009:G:A | NC_000006.12:31575253:G:A | (self) |
| ss109901711, ss116394700, ss162198777, ss201626002, ss254187389, ss278727093, ss285374156, ss480300551, ss1592310303, ss1712851078, ss2635155642, ss3643561243 | NC_000006.10:31651009:G:A | NC_000006.12:31575253:G:A | (self) |
| 31326286, 17467583, 12449060, 8256040, 7771759, 85675752, 4791395, 628263, 7765195, 18207891, 236895, 6646998, 8060710, 16272561, 4325367, 17467583, ss222304163, ss233399218, ss240469923, ss480311656, ss481067278, ss484948088, ss491381906, ss536992328, ss653035581, ss712699264, ss778467783, ss780682574, ss782920352, ss783355928, ss783883384, ss832175477, ss833923542, ss974459603, ss982766421, ss1067477166, ss1073506038, ss1319558829, ss1581606820, ss1615278019, ss1658272052, ss1688230716, ss1711121135, ss1752628691, ss1752628692, ss1917802451, ss1926018780, ss1946173378, ss1958888381, ss2023642576, ss2094824801, ss2095178036, ss2151809013, ss2451321803, ss2626308723, ss2634429968, ss2707402813, ss2711069578, ss2735648837, ss2747581793, ss2837428886, ss2985362252, ss2985994164, ss2998796491, ss3022599572, ss3625897843, ss3629503652, ss3629503653, ss3632348527, ss3633415350, ss3634137836, ss3635057013, ss3635057014, ss3635818854, ss3636778275, ss3637571638, ss3638619862, ss3640764312, ss3640764313, ss3644906437, ss3646334755, ss3653112183, ss3653112184, ss3654128111, ss3666710812, ss3733362133, ss3744549890, ss3745357013, ss3745357014, ss3764822995, ss3772850714, ss3772850715, ss3824170220, ss3825694226, ss3829833058, ss3838394885, ss3864255581, ss3911030497 | NC_000006.11:31543030:G:A | NC_000006.12:31575253:G:A | (self) |
| RCV000211242.1, RCV000211284.1, RCV000211408.1, RCV000211419.1, 3100211, 500426, 10675, 335045729, 413541372, ss2282946228, ss3025608431, ss3493847195, ss3654261673, ss3716909250, ss3726330083, ss3771278957, ss3807978245, ss3843837070 | NC_000006.12:31575253:G:A | NC_000006.12:31575253:G:A | (self) |
| ss2420741, ss4328930, ss4377317, ss5586943, ss6310583, ss6312900, ss12691494, ss16360688, ss16360736, ss51854703, ss52088979, ss65843449, ss66857511, ss66859809, ss68971678, ss69366252, ss75254821, ss76873614, ss86217651, ss95216268, ss104296823, ss156747688, ss160462872, ss172924883, ss244285039, ss410916050 | NT_007592.15:31483030:G:A | NC_000006.12:31575253:G:A | (self) |
Help
Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.
633
citations for rs1800629
| PMID | Title | Author | Year | Journal |
|---|---|---|---|---|
| 12190096 | A positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism. | Louis E et al. | 2002 | Scandinavian journal of gastroenterology |
| 12759288 | Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis. | Padyukov L et al. | 2003 | Annals of the rheumatic diseases |
| 12847678 | Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis. | Mugnier B et al. | 2003 | Arthritis and rheumatism |
| 15726497 | Gene-environment interaction effects on the development of immune responses in the 1st year of life. | Hoffjan S et al. | 2005 | American journal of human genetics |
| 15797957 | Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women. | Moffett SP et al. | 2005 | The Journal of clinical endocrinology and metabolism |
| 15817713 | Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. | Hersh CP et al. | 2005 | American journal of respiratory cell and molecular biology |
| 15834068 | Polymorphism at position -308 of the tumour necrosis factor alpha gene and rheumatoid arthritis pharmacogenetics. | Fonseca JE et al. | 2005 | Annals of the rheumatic diseases |
| 15895461 | TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels. | Laws SM et al. | 2005 | Human mutation |
| 16046815 | Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes. | Wren JD et al. | 2005 | Journal of biomedicine & biotechnology |
| 16385446 | A testing framework for identifying susceptibility genes in the presence of epistasis. | Millstein J et al. | 2006 | American journal of human genetics |
| 16449530 | Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. | Lan Q et al. | 2006 | Blood |
| 16617143 | Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data. | Callegaro A et al. | 2006 | Nucleic acids research |
| 16672072 | The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome. | Chong WP et al. | 2006 | BMC infectious diseases |
| 16720636 | The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients. | Seitz M et al. | 2007 | Rheumatology (Oxford, England) |
| 16759385 | Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA). | Imboden M et al. | 2006 | Clinical and molecular allergy |
| 16820586 | Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. | Podgoreanu MV et al. | 2006 | Circulation |
| 16846490 | Lemierre's syndrome and genetic polymorphisms: a case report. | Constantin JM et al. | 2006 | BMC infectious diseases |
| 16872485 | Three allele combinations associated with multiple sclerosis. | Favorova OO et al. | 2006 | BMC medical genetics |
| 16909270 | Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. | Lee YH et al. | 2006 | Rheumatology international |
| 17018637 | Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma. | Wang SS et al. | 2006 | Cancer research |
| 17054776 | The genetics of chronic obstructive pulmonary disease. | Wood AM et al. | 2006 | Respiratory research |
| 17174749 | Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility. | Noble JA et al. | 2006 | Human immunology |
| 17216494 | Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk. | Gaudet MM et al. | 2007 | Human genetics |
| 17327408 | Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. | Cerhan JR et al. | 2007 | Blood |
| 17343250 | Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. | Cuchacovich M et al. | 2006 | Scandinavian journal of rheumatology |
| 17450233 | Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma. | Wu H et al. | 2007 | Environmental health perspectives |
| 17510437 | Immune mechanisms in non-Hodgkin lymphoma: joint effects of the TNF G308A and IL10 T3575A polymorphisms with non-Hodgkin lymphoma risk factors. | Wang SS et al. | 2007 | Cancer research |
| 17668374 | Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. | Ayodo G et al. | 2007 | American journal of human genetics |
| 17673491 | A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis. | Miceli-Richard C et al. | 2008 | Annals of the rheumatic diseases |
| 17701899 | Flexible design for following up positive findings. | Yu K et al. | 2007 | American journal of human genetics |
| 17705862 | Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples. | Pullat J et al. | 2007 | BMC genomics |
| 18041006 | Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. | Pereira FA et al. | 2008 | Journal of medical virology |
| 18050183 | Influence of -308 A/G polymorphism in the tumor necrosis factor alpha gene on etanercept treatment in rheumatoid arthritis. | Guis S et al. | 2007 | Arthritis and rheumatism |
| 18194515 | Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population. | Sinha S et al. | 2008 | Malaria journal |
| 18196539 | TNF polymorphisms and prostate cancer risk. | Danforth KN et al. | 2008 | The Prostate |
| 18307517 | Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans. | Taudorf S et al. | 2008 | Clinical and experimental immunology |
| 18319718 | Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis. | Gorouhi F et al. | 2008 | British journal of cancer |
| 18398712 | No association found between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes. | Wang N et al. | 2008 | Current eye research |
| 18423522 | Estimating odds ratios in genome scans: an approximate conditional likelihood approach. | Ghosh A et al. | 2008 | American journal of human genetics |
| 18426866 | Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. | Marvelle AF et al. | 2008 | Diabetes |
| 18434886 | Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor. | Menges T et al. | 2008 | Critical care medicine |
| 18438841 | Association between the level of circulating bioactive tumor necrosis factor alpha and the tumor necrosis factor alpha gene polymorphism at -308 in patients with rheumatoid arthritis treated with a tumor necrosis factor alpha inhibitor. | Marotte H et al. | 2008 | Arthritis and rheumatism |
| 18513389 | New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. | Penco S et al. | 2008 | BMC bioinformatics |
| 18515978 | Association of tumor necrosis factor -308G/A promoter polymorphism with schizophrenia and bipolar affective disorder in a Polish population. | Czerski PM et al. | 2008 | Neuropsychobiology |
| 18520591 | Sequence variants in host cell factor C1 are associated with Ménière's disease. | Vrabec JT et al. | 2008 | Otology & neurotology |
| 18551993 | SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women. | Lin GT et al. | 2008 | The Chinese journal of physiology |
| 18575614 | Association between LTA, TNF and AGER polymorphisms and late diabetic complications. | Lindholm E et al. | 2008 | PloS one |
| 18603647 | Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response. | Simoni M et al. | 2008 | Human reproduction update |
| 18615156 | Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. | Liu C et al. | 2008 | Molecular medicine (Cambridge, Mass.) |
| 18620570 | The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency. | Wood AM et al. | 2008 | Respiratory research |
| 18633131 | Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era. | Habermann TM et al. | 2008 | Blood |
| 18635873 | TNF promoter polymorphisms associated with muscle phenotypes in humans. | Liu D et al. | 2008 | Journal of applied physiology (Bethesda, Md. |
| 18640487 | Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation. | Israni AK et al. | 2008 | American journal of kidney diseases |
| 18676870 | Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. | Hsing AW et al. | 2008 | Cancer research |
| 18698679 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk. | Ferguson LR et al. | 2008 | World journal of gastroenterology |
| 18709160 | Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. | Melén E et al. | 2008 | Environmental health perspectives |
| 18713756 | Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. | Maxwell JR et al. | 2008 | Human molecular genetics |
| 18715339 | Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. | Dhiman N et al. | 2008 | Tissue antigens |
| 18796628 | Etiologic heterogeneity among non-Hodgkin lymphoma subtypes. | Morton LM et al. | 2008 | Blood |
| 18805939 | Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis. | Tempfer CB et al. | 2009 | Human reproduction update |
| 18811622 | Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma. | Puthothu B et al. | 2009 | Pediatric allergy and immunology |
| 18936436 | Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. | Chang MH et al. | 2009 | American journal of epidemiology |
| 18990758 | Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. | Cerhan JR et al. | 2008 | Cancer epidemiology, biomarkers & prevention |
| 19035456 | Adipokine genes and prostate cancer risk. | Moore SC et al. | 2009 | International journal of cancer |
| 19035492 | Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis. | Mamyrova G et al. | 2008 | Arthritis and rheumatism |
| 19039607 | A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility. | Diakite M et al. | 2009 | Human genetics |
| 19066394 | Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. | Colt JS et al. | 2009 | Blood |
| 19126646 | Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA. | Ognjanovic S et al. | 2009 | Carcinogenesis |
| 19131662 | A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. | Wang X et al. | 2009 | Stroke |
| 19147066 | Genomic and proteomic analysis of allogeneic hematopoietic cell transplant outcome. Seeking greater understanding the pathogenesis of GVHD and mortality. | Hansen JA et al. | 2009 | Biology of blood and marrow transplantation |
| 19167443 | Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia. | Boraska V et al. | 2009 | Human immunology |
| 19225544 | Variation in the lymphotoxin-alpha/tumor necrosis factor locus modifies risk of erythema nodosum in sarcoidosis. | McDougal KE et al. | 2009 | The Journal of investigative dermatology |
| 19233472 | Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection. | Chen Y et al. | 2009 | Molecular immunology |
| 19263529 | Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. | Zee RY et al. | 2009 | Clinica chimica acta; international journal of clinical chemistry |
| 19279689 | TNF-alpha -308 G>A and -238 G>A polymorphisms are not major risk factors in Caucasian patients with exfoliation glaucoma. | Mossböck G et al. | 2009 | Molecular vision |
| 19281305 | Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. | Clark TG et al. | 2009 | The Journal of infectious diseases |
| 19330901 | Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. | Conen D et al. | 2009 | Journal of hypertension |
| 19347053 | Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion. | Steinbrugger I et al. | 2009 | Molecular vision |
| 19356949 | Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies. | Van Dyke AL et al. | 2009 | Cytokine |
| 19365401 | TNF-alpha-308 G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis. | O'Rielly DD et al. | 2009 | The pharmacogenomics journal |
| 19386798 | Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever. | Forte GI et al. | 2009 | Clinical and vaccine immunology |
| 19401444 | Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism. | Martínez-García MA et al. | 2009 | Diabetes care |
| 19405090 | Genetic polymorphisms in chronic hyperplastic sinusitis with nasal polyposis. | Bernstein JM et al. | 2009 | The Laryngoscope |
| 19409079 | Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study. | Kirsten H et al. | 2009 | Arthritis research & therapy |
| 19419979 | Preliminary evidence of a genetic association between tumor necrosis factor alpha and the severity of sleep disturbance and morning fatigue. | Aouizerat BE et al. | 2009 | Biological research for nursing |
| 19438866 | Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk. | Gu F et al. | 2009 | The British journal of dermatology |
| 19478423 | Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levels. | Belisle SE et al. | 2008 | BioFactors (Oxford, England) |
| 19505919 | Toll-like receptor signaling pathway variants and prostate cancer mortality. | Stark JR et al. | 2009 | Cancer epidemiology, biomarkers & prevention |
| 19559392 | A candidate gene association study of 77 polymorphisms in migraine. | Schürks M et al. | 2009 | The journal of pain |
| 19615068 | The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study. | Yang JJ et al. | 2009 | BMC cancer |
| 19654554 | The major histocompatibility complex conserved extended haplotype 8.1 in AIDS-related non-Hodgkin lymphoma. | Aissani B et al. | 2009 | Journal of acquired immune deficiency syndromes (1999) |
| 19661089 | Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. | Hussain SK et al. | 2009 | Cancer epidemiology, biomarkers & prevention |
| 19673019 | IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location. | Sanchez R et al. | 2009 | World journal of gastroenterology |
| 19700502 | Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system. | Zintzaras E et al. | 2009 | American journal of epidemiology |
| 19732761 | Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves' disease. | Gu LQ et al. | 2010 | Clinical biochemistry |
| 19773451 | Role of inflammation gene polymorphisms on pain severity in lung cancer patients. | Reyes-Gibby CC et al. | 2009 | Cancer epidemiology, biomarkers & prevention |
| 19933216 | The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. | Castaldi PJ et al. | 2010 | Human molecular genetics |
| 19934104 | Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. | Attur M et al. | 2010 | Annals of the rheumatic diseases |
| 19951401 | Chronic obstructive pulmonary disease: towards pharmacogenetics. | Wood AM et al. | 2009 | Genome medicine |
| 20007930 | A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations. | Möller M et al. | 2010 | American journal of respiratory and critical care medicine |
| 20012999 | The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer. | Jatoi A et al. | 2010 | Supportive care in cancer |
| 20031567 | An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study. | Zee RY et al. | 2009 | Circulation. Cardiovascular genetics |
| 20047977 | Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium. | Skibola CF et al. | 2010 | American journal of epidemiology |
| 20049212 | Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS). | Castro-Giner F et al. | 2009 | Environmental health perspectives |
| 20080841 | Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components. | Phillips CM et al. | 2010 | The Journal of clinical endocrinology and metabolism |
| 20083555 | Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians. | Dato S et al. | 2010 | The journals of gerontology. Series A, Biological sciences and medical sciences |
| 20087644 | Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma. | Fernberg P et al. | 2010 | Cancer causes & control |
| 20112337 | Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers. | Oh SS et al. | 2010 | International journal of cancer |
| 20113413 | Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation. | Yilmaz IA et al. | 2010 | Pain medicine (Malden, Mass.) |
| 20132806 | Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population. | Bouhaha R et al. | 2010 | Clinical biochemistry |
| 20157068 | Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study. | Mfuna Endam L et al. | 2010 | Archives of otolaryngology--head & neck surgery |
| 20177654 | Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians. | Mahajan A et al. | 2010 | Journal of molecular medicine (Berlin, Germany) |
| 20206339 | Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells. | Wienzek S et al. | 2010 | Cellular immunology |
| 20227257 | Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians. | Shaffer JR et al. | 2011 | Nutrition, metabolism, and cardiovascular diseases |
| 20357201 | Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. | Fan BJ et al. | 2010 | Investigative ophthalmology & visual science |
| 20357209 | Molecular genetic studies of gene identification for osteoporosis: the 2009 update. | Xu XH et al. | 2010 | Endocrine reviews |
| 20361391 | The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study. | Kilpeläinen TO et al. | 2010 | Experimental and clinical endocrinology & diabetes |
| 20396431 | Genotyping sleep disorders patients. | Kripke DF et al. | 2010 | Psychiatry investigation |
| 20401335 | Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype. | Driss A et al. | 2009 | Genomics insights |
| 20417488 | Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years. | Clark EA et al. | 2010 | American journal of obstetrics and gynecology |
| 20418110 | Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer. | Erdei E et al. | 2010 | Cytokine |
| 20431935 | Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk. | Zhang J et al. | 2010 | Cancer causes & control |
| 20459604 | Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes. | Boraska V et al. | 2010 | BMC medical genetics |
| 20461113 | A screening methodology based on Random Forests to improve the detection of gene-gene interactions. | De Lobel L et al. | 2010 | European journal of human genetics |
| 20463618 | Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. | Abu-Maziad A et al. | 2010 | Pediatric research |
| 20473875 | Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians. | Zabaleta J et al. | 2011 | International journal of cancer |
| 20564140 | Relationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors. | Rausch SM et al. | 2010 | Cancer |
| 20565774 | Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project. | Cross DS et al. | 2010 | BMC genetics |
| 20570482 | Preliminary evidence of an association between a functional interleukin-6 polymorphism and fatigue and sleep disturbance in oncology patients and their family caregivers. | Miaskowski C et al. | 2010 | Journal of pain and symptom management |
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| 28361429 | Possible Role of Polymorphisms in TNFA, NFKB1, and CASP8 Gene Promoter Areas in the Development of Chronic Lymphocytic Leukemia. | Ovsepyan VA et al. | 2017 | Bulletin of experimental biology and medicine |
| 28374494 | Immunogenetic profiling of 23 SNPs of cytokine and chemokine receptor genes through a minisequencing technique: Design, development and validation. | Valverde-Villegas JM et al. | 2017 | International journal of immunogenetics |
| 28384885 | Profile of Tumour Necrosis Factor Alpha -308 G/A Gene Polymorphism in Psoriatic Patients in Karnataka, India. | Rajesh D et al. | 2017 | Journal of clinical and diagnostic research |
| 28388928 | SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature. | Bokharaeian B et al. | 2017 | Journal of biomedical semantics |
| 28395167 | The association of Enamelin, Lactoferrin, and Tumour necrosis factor alpha gene polymorphisms with high caries susceptibility in Chinese children under 4 years old. | Wang M et al. | 2017 | Archives of oral biology |
| 28464990 | EPHX1 Y113H polymorphism is associated with increased risk of chronic obstructive pulmonary disease in Kazakhstan population. | Akparova A et al. | 2017 | Mutation research. Genetic toxicology and environmental mutagenesis |
| 28495402 | Associations of tumor necrosis factor-α-308 polymorphism with dengue infection: A systematic review and meta-analysis. | Pabalan N et al. | 2017 | Acta tropica |
| 28501927 | Cytokine gene polymorphism associations with congenital cytomegalovirus infection and sensorineural hearing loss. | Kasztelewicz B et al. | 2017 | European journal of clinical microbiology & infectious diseases |
| 28527290 | Association of polymorphic variants of PTPN22, TNF and VDR genes in children with lupus nephritis: A study in Colombian family triads. | Garavito G et al. | 2017 | Biomedica |
| 28575042 | TNF-α -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China. | Li Z et al. | 2017 | PloS one |
| 28620227 | Gene-physical activity interactions in lower extremity performance: inflammatory genes CRP, TNF-α, and LTA in community-dwelling elders. | Liu CS et al. | 2017 | Scientific reports |
| 28620993 | The Role of TLR4, TNF-α and IL-1β in Type 2 Diabetes Mellitus Development within a North Indian Population. | Doody NE et al. | 2017 | Annals of human genetics |
| 28633686 | Polymorphisms of the TNF-α gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in São Paulo, Brazil. | Oki E et al. | 2017 | The British journal of nutrition |
| 28652652 | Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update. | Sharma A et al. | 2017 | World journal of gastroenterology |
| 28675059 | Immunogenetic predisposing factors for mesial temporal lobe epilepsy with hippocampal sclerosis. | Leal B et al. | 2018 | The International journal of neuroscience |
| 28695434 | The single-nucleotide polymorphism (SNP) of tumor necrosis factor α -308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population. | Abdel Galil SM et al. | 2017 | Clinical rheumatology |
| 28702675 | TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus. | Arbab M et al. | 2017 | Investigative ophthalmology & visual science |
| 28703132 | Association of a functional TNF variant with Plasmodium falciparum parasitaemia in a congolese population. | Nguyen TN et al. | 2017 | Genes and immunity |
| 28716390 | Impact of cytokine genetic polymorphisms on the risk of renal parenchymal infection in children. | Hussein A et al. | 2017 | Journal of pediatric urology |
| 28740106 | Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes. | Song Y et al. | 2017 | Scientific reports |
| 28765340 | Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium. | Campa D et al. | 2017 | Cancer epidemiology, biomarkers & prevention |
| 28785150 | Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease. | Netz U et al. | 2017 | World journal of gastroenterology |
| 28827564 | The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction. | Bielecka-Dabrowa A et al. | 2017 | Scientific reports |
| 28844157 | Validation of genetic predictors of late radiation-induced morbidity in prostate cancer patients. | Schack LMH et al. | 2017 | Acta oncologica (Stockholm, Sweden) |
| 28881857 | Genetic association between <i>TNF-α</i> promoter polymorphism and susceptibility to squamous cell carcinoma, basal cell carcinoma, and melanoma: A meta-analysis. | Liu N et al. | 2017 | Oncotarget |
| 28935761 | Impact of <i>TNF</i> -308 G>A (rs1800629) gene polymorphism in modulation of leprosy risk: a reappraise meta-analysis of 14 case-control studies. | Areeshi MY et al. | 2017 | Bioscience reports |
| 28963676 | Genetic variants of tumor necrosis factor-α -308G/A (rs1800629) but not Toll-interacting proteins or vitamin D receptor genes enhances susceptibility and severity of malaria infection. | Ojurongbe O et al. | 2018 | Immunogenetics |
| 28980933 | Predictive role of cytokines IL-10, IL-12 and TNF-α gene polymorphisms for the development of osteonecrosis of the femoral head in the Chinese Han population. | Yuan L et al. | 2017 | Cellular and molecular biology (Noisy-le-Grand, France) |
| 28993561 | A Missense Variant rs4645843 in TNF-α Gene Is a Risk Factor of Polycystic Ovary Syndrome in the Uygur Population. | Li S et al. | 2017 | The Tohoku journal of experimental medicine |
| 29041886 | [Polymorphisms in Genes of Cytokines and Matrix Metalloproteinases Associated With Ischemic Heart Disease in Patients With Type 2 Diabetes]. | Klimontov VV et al. | 2017 | Kardiologiia |
| 29042282 | Increased levels of circulating (TNF-α) is associated with (-308G/A) promoter polymorphism of TNF-α gene in Diabetic Nephropathy. | Umapathy D et al. | 2018 | International journal of biological macromolecules |
| 29054398 | Association of TNF-Alpha gene polymorphisms and susceptibility to hepatitis B virus infection in Egyptians. | Talaat RM et al. | 2017 | Human immunology |
| 29056124 | Association of ADIPOQ C-11377G (rs266729), TNF-α αG-308A(rs1800629) and TNF-α αG-238A(rs361525) Single Nucleotide Polymorphisms with Type 2 Diabetes Mellitus in Pakistani Population. | Nadeem A et al. | 2017 | Journal of the College of Physicians and Surgeons--Pakistan |
| 29130827 | Association of Single-Nucleotide Polymorphisms in Immune-Related Genes with Development of Dengue Hemorrhagic Fever in a Mexican Population. | Vargas-Castillo AB et al. | 2018 | Viral immunology |
| 29136357 | Association of cytokine gene polymorphisms with bronchopulmonary dysplasia in Han Chinese newborns. | Chen H et al. | 2018 | Pediatric pulmonology |
| 29164277 | High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil. | Pereira ACTDC et al. | 2018 | Immunogenetics |
| 29172674 | Single nucleotide polymorphisms in TNF are associated with susceptibility to aspirin-exacerbated respiratory disease but not to cytokine levels: a study in Mexican mestizo population. | Pavón-Romero GF et al. | 2017 | Biomarkers in medicine |
| 29181663 | Gene TNF Polymorphism -308G>A (rs1800629) and Its Relationship with the Efficiency of Ursodeoxycholic Acid Therapy in Patients with Nonalcoholic Stetohepatitis. | Kurbatova IV et al. | 2017 | Bulletin of experimental biology and medicine |
| 29193749 | Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years. | Borobia AM et al. | 2018 | Clinical and translational science |
| 29218062 | Preliminary Study Regarding the Association between Tumor Necrosis Factor Alpha Gene Polymorphisms and Childhood Idiopathic Nephrotic Syndrome in Romanian Pediatric Patients. | Tieranu I et al. | 2017 | Maedica |
| 29230494 | Association of polymorphisms in TNF and GRN genes with ankylosing spondylitis in a Chinese Han population. | Hu N et al. | 2018 | Rheumatology international |
| 29247331 | Polymorphisms in inflammation-related genes and the risk of primary varicose veins in ethnic Russians. | Shadrina A et al. | 2018 | Immunologic research |
| 29256014 | Genetic variation in TNFα, PPARγ, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort. | Duggan C et al. | 2018 | Breast cancer research and treatment |
| 29298134 | The Synergistic Effect of TNFA and IL10 Promoter Polymorphisms on Genetic Predisposition to Systemic Lupus Erythematosus. | Manolova I et al. | 2018 | Genetic testing and molecular biomarkers |
| 29340067 | The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk. | Zhang Y et al. | 2017 | Oncotarget |
| 29388847 | The role of TNF alpha polymorphism and expression in susceptibility to nasal polyposis. | Zhang G et al. | 2018 | Immunological investigations |
| 29404828 | Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population. | Cadena-Sandoval D et al. | 2018 | Molecular biology reports |
| 29406912 | TNF-α -308 G/A and -238 G/A promoter polymorphisms and sporadic Parkinson's disease in an Italian cohort. | Agliardi C et al. | 2018 | Journal of the neurological sciences |
| 29426041 | Genetic Polymorphisms in Cytokine Genes in Colombian Patients with Ocular Toxoplasmosis. | Naranjo-Galvis CA et al. | 2018 | Infection and immunity |
| 29430075 | Polymorphisms in the <i>SP110</i> and <i>TNF-α</i> Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population. | Zhou Y et al. | 2017 | Disease markers |
| 29440561 | Association of <i>TNF-α</i> promoter polymorphism and Graves' disease: an updated systematic review and meta-analysis. | Tu Y et al. | 2018 | Bioscience reports |
| 29449347 | Association of tumor necrosis factor-α (TNF-α) gene promoter polymorphisms with aggressive and chronic periodontitis in the eastern Indian population. | Majumder P et al. | 2018 | Bioscience reports |
| 29481288 | Replication Study Confirms the Association of the Common rs1800629 Variant of the TNFα Gene with Postmenopausal Osteoporosis Susceptibility in the Han Chinese Population. | Jin X et al. | 2018 | Genetic testing and molecular biomarkers |
| 29497291 | <i>TNF</i> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning. | Reséndiz-Hernández JM et al. | 2018 | International journal of chronic obstructive pulmonary disease |
| 29519182 | Interactions among insulin resistance, inflammation factors, obesity-related gene polymorphisms, environmental risk factors, and diet in the development of gestational diabetes mellitus. | Feng Y et al. | 2019 | The journal of maternal-fetal & neonatal medicine |
| 29605608 | Genetic variations in key inflammatory cytokines exacerbates the risk of diabetic nephropathy by influencing the gene expression. | Hameed I et al. | 2018 | Gene |
| 29611038 | Tumor necrosis factor gene polymorphisms are associated with systemic lupus erythematosus susceptibility or lupus nephritis in Mexican patients. | Ramírez-Bello J et al. | 2018 | Immunologic research |
| 29624745 | Atopic dermatitis: Interaction between genetic variants of GSTP1, TNF, TLR2, and TLR4 and air pollution in early life. | Hüls A et al. | 2018 | Pediatric allergy and immunology |
| 29673983 | Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease. | Oliveira M et al. | 2018 | Infection, genetics and evolution |
| 29696068 | Gene polymorphisms of TNF-238G/A, TNF-308G/A, IL10-1082G/A, TNFAIP3, and MC4R and comorbidity occurrence in a Romanian population with psoriasis. | Voiculescu VM et al. | 2018 | Journal of medicine and life |
| 29734056 | Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian. | Kumari R et al. | 2018 | Cytokine |
| 29768622 | Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil. | Alvarado-Arnez LE et al. | 2018 | Memorias do Instituto Oswaldo Cruz |
| 29846433 | Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population. | Chen J et al. | 2018 | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas |
| 29849482 | Influence of <i>TNF</i> and <i>IL17</i> Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population. | Rocha Loures MA et al. | 2018 | Mediators of inflammation |
| 29862067 | Comparison of SNP Genotypes Related to Proliferative Vitreoretinopathy (PVR) across Slovenian and European Subpopulations. | Lumi X et al. | 2018 | Journal of ophthalmology |
| 29898681 | Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(-) mothers. | Cao MZ et al. | 2018 | BMC infectious diseases |
| 29935877 | Significant association between IL10-1082/-819 and TNF-308 haplotypes and the susceptibility to cervical carcinogenesis in women infected by Human papillomavirus. | Chagas BS et al. | 2019 | Cytokine |
| 29940817 | The Correlation Between TNF-α Promoter Gene Polymorphism and Genetic Susceptibility to Cervical Cancer. | Li X et al. | 2018 | Technology in cancer research & treatment |
| 30009916 | Single nucleotide polymorphisms in cytokine/chemokine genes are associated with severe infection, ulcer grade and amputation in diabetic foot ulcer. | Viswanathan V et al. | 2018 | International journal of biological macromolecules |
| 30027452 | The Potential Role of TNF-α (rs361525 and rs1800629) in Hepatocellular Carcinoma: Multivariate Analysis (Meta-Analysis). | Heidari Horestani M et al. | 2019 | Journal of gastrointestinal cancer |
| 30109734 | Polymorphisms in TH1-TH2 cytokine and receptor genes associated with risk of vertical HIV transmission, in Mumbai, India. | Ahir-Bist S et al. | 2018 | The journal of gene medicine |
| 30112393 | Combination of Genetic Markers and Age Effectively Facilitates the Identification of People with High Risk of Preeclampsia in the Han Chinese Population. | Zhou L et al. | 2018 | BioMed research international |
| 30116153 | Involvement of the IL23/Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus. | Ben Jmaa M et al. | 2018 | Mediators of inflammation |
| 30124928 | TNF-α Stress Response Is Reduced Following Load Carriage Training. | Jensen AE et al. | 2019 | Military medicine |
| 30186498 | Association of cytokine gene polymorphisms with osteoarthritis susceptibility. | Rogoveanu OC et al. | 2018 | Experimental and therapeutic medicine |
| 30204505 | Impact of IL-27p28 (rs153109) and TNF-α (rs1800629) Genetic Polymorphisms on the Progression of HCV Infection in Egyptian Patients. | Tharwat E et al. | 2019 | Immunological investigations |
| 30206443 | Genetic polymorphism in psoriasis and its meaning for the treatment efficacy in the future. | Osmola-Mańkowska A et al. | 2018 | Postepy dermatologii i alergologii |
| 30208882 | Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis. | Sode J et al. | 2018 | BMC medical genetics |
| 30235774 | Systematic meta-analysis of genetic variants associated with osteosarcoma susceptibility. | Wang X et al. | 2018 | Medicine |
| 30367528 | DC-SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations. | Alves Pereira Neto T et al. | 2019 | Mycoses |
| 30383538 | The influence of the <i>TNFα</i> rs1800629 polymorphism on some inflammatory biomarkers in 45-60-year-old women with metabolic syndrome. | Szkup M et al. | 2018 | Aging |
| 30412745 | Genetic variations in inflammation-related genes and their influence on the susceptibility of pediatric acute lung injury in a Chinese population. | Zhao X et al. | 2019 | Gene |
| 30430914 | Genetic polymorphism contributes to <sup>131</sup>I radiotherapy-induced toxicities in patients with differentiated thyroid cancer. | Liu J et al. | 2018 | Pharmacogenomics |
| 30475169 | Association of Single Nucleotide Polymorphisms in <i>TNFA</i> and <i>IL10</i> Genes with Disease Severity in Influenza A/H1N1pdm09 Virus Infections: A Study from Western India. | Choudhary ML et al. | 2018 | Viral immunology |
| 30509964 | A trial sequential meta-analysis of <i>TNF-</i>α -308G>A (rs800629) gene polymorphism and susceptibility to colorectal cancer. | Mandal RK et al. | 2019 | Bioscience reports |
| 30557992 | Association between rs1800629 polymorphism in tumor necrosis factor-α gene and dilated cardiomyopathy susceptibility: Evidence from case-control studies. | Zhang Y et al. | 2018 | Medicine |
| 30584432 | Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study. | Daneshpour MS et al. | 2018 | International journal of endocrinology and metabolism |
| 30584776 | Association of TNF, IL12, and IL23 gene polymorphisms and psoriatic arthritis: meta-analysis. | Loures MAR et al. | 2019 | Expert review of clinical immunology |
| 30595251 | Tumor necrosis factor-alpha -308G/A gene polymorphism and novel biomarker profiles in patients with Takayasu arteritis. | Sarkar PG et al. | 2018 | Indian heart journal |
| 30610785 | TNF-α-308G/A polymorphism and the risk of colorectal cancer: A systematic review and an updated meta-analysis. | Miao Z et al. | 2018 | Journal of B.U.ON. |
| 30662836 | <i>TNF-α</i> gene polymorphisms: association with age-related macular degeneration in Russian population. | Chernykh V et al. | 2019 | International journal of ophthalmology |
| 30701793 | Association between polymorphic markers in candidate genes and the risk of manifestationof endocrine ophthalmopathy in patients with Graves' disease. | Petunina NA et al. | 2018 | Terapevticheskii arkhiv |
| 30727925 | Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A. | Soori S et al. | 2019 | Cardiovascular & hematological disorders drug targets |
| 30781715 | Genetic Epidemiology of Breast Cancer in Latin America. | Zavala VA et al. | 2019 | Genes |
| 30792445 | Polymorphisms of cytokine genes and tuberculosis in two independent studies. | Wu S et al. | 2019 | Scientific reports |
| 30793520 | Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies. | Tian J et al. | 2019 | Cancer medicine |
| 30807515 | SINGLE NUCLEOTIDE POLYMORPHISMS IN RETINAL DETACHMENT PATIENTS WITH AND WITHOUT PROLIFERATIVE VITREORETINOPATHY. | Lumi X et al. | 2020 | Retina (Philadelphia, Pa.) |
| 30813952 | Genetic variability of inflammation and oxidative stress genes does not play a major role in the occurrence of adverse events of dopaminergic treatment in Parkinson's disease. | Redenšek S et al. | 2019 | Journal of neuroinflammation |
| 30815272 | Genetic polymorphisms in tumour necrosis factor receptors (<i>TNFRSF1A/1B</i>) illustrate differential treatment response to TNFα inhibitors in patients with Crohn's disease. | Qasem A et al. | 2019 | BMJ open gastroenterology |
| 30843750 | Genetic variants linked to folliculogenesis and successful pregnancy are not associated with twin births in a twins' town. | Cardoso-Dos-Santos AC et al. | 2020 | The journal of maternal-fetal & neonatal medicine |
| 30900134 | TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women. | Włodarczyk M et al. | 2020 | Molecular biology reports |
| 30916218 | Association between tumor necrosis factor polymorphisms and rheumatoid arthritis as well as systemic lupus erythematosus: a meta-analysis. | Chen L et al. | 2019 | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas |
| 30923465 | SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren's syndrome. | Ben-Eli H et al. | 2019 | Journal of inflammation (London, England) |
| 30954991 | Association of TLR4 and TNF-a Gene Polymorphisms and TLR4 mRNA Levels in Preterm Birth in a Northern Indian Population. | Awasthi S et al. | 2019 | Indian pediatrics |
| 30967802 | Understanding the Relation Between Early-Life Adversity and Depression Symptoms: The Moderating Role of Sex and an Interleukin-1β Gene Variant. | McQuaid RJ et al. | 2019 | Frontiers in psychiatry |
| 30970058 | Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion. | Levy SC et al. | 2019 | Brazilian dental journal |
| 30973927 | Single nucleotide polymorphism analysis in interstitial cystitis/painful bladder syndrome. | Cassão VD et al. | 2019 | PloS one |
| 31023072 | Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms. | Knisely MR et al. | 2019 | Biological research for nursing |
| 31026237 | Increasing Levels of Serum Heat Shock Protein 70 Precede the Development of AIDS-Defining Non-Hodgkin Lymphoma Among Carriers of HLA-B8-DR3. | Aissani B et al. | 2019 | Journal of acquired immune deficiency syndromes (1999) |
| 31044631 | Association between Genetic Polymorphisms of Inflammatory Response Genes and Acute Pancreatitis. | Rodriguez-Nicolas A et al. | 2019 | Immunological investigations |
| 31046486 | The study of methylation and single nucleotide polymorphisms of cancer-related genes in patients with early-stage ulcerative colitis. | Chen HX et al. | 2019 | Scandinavian journal of gastroenterology |
| 31054364 | Multilocus associations of inflammatory genes with the risk of type 1 diabetes. | Timasheva YR et al. | 2019 | Gene |
| 31063409 | Relationship Between Genetic Polymorphisms of the <i>TNF</i> Gene and Hallux Valgus Susceptibility. | Yang J et al. | 2019 | Genetic testing and molecular biomarkers |
| 31071395 | The role of TNF-α and TLR4 polymorphisms in the placenta of pregnant women complicated by preeclampsia and in silico analysis. | Mohammadpour-Gharehbagh A et al. | 2019 | International journal of biological macromolecules |
| 31092242 | Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population. | Martínez-Campos C et al. | 2019 | BMC cancer |
| 31129315 | Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain. | Chidambaran V et al. | 2020 | The journal of pain |
| 31132515 | Association of TNF-α gene alterations (c.-238G>A, c.-308G>A, c.-857C>T, c.-863C>A) with primary glaucoma in north Indian cohort. | Passan S et al. | 2019 | Gene |
| 31148856 | Investigation of Immunovascular Polymorphisms and Intersections in Psoriasis. | Urganci BE et al. | 2019 | Indian journal of dermatology |
| 31210414 | Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea. | Zhang Z et al. | 2019 | Molecular genetics & genomic medicine |
| 31231424 | Genetic and Epigenetic Studies in Diabetic Kidney Disease. | Gu HF et al. | 2019 | Frontiers in genetics |
| 31260854 | TNF-α -308 G/A variant and susceptibility to chronic obstructive pulmonary disease: A systematic review and meta-analysis. | Salimi Asl M et al. | 2019 | Cytokine |
| 31261506 | TLR4/NF-κB signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes. | Ding Y et al. | 2019 | Medicine |
| 31272196 | Cytokine Genetic Variants and Health-Related Quality of Life in Crohn's Disease: An Exploratory Study. | Knisely MR et al. | 2019 | Biological research for nursing |
| 31324728 | Association study of a functional variant of TNF-α gene and serum TNF-α level with the susceptibility of congenital heart disease in a Chinese population. | Pan J et al. | 2019 | Postgraduate medical journal |
| 31342641 | Single-nucleotide polymorphisms associated with pemphigus vulgaris: Potent markers for better treatment and personalized medicine. | Mahmoudi H et al. | 2020 | International journal of immunogenetics |
| 31350695 | Year-Long Rhinovirus Infection is Influenced by Atmospheric Conditions, Outdoor Air Virus Presence, and Immune System-Related Genetic Polymorphisms. | Rodrigues AF et al. | 2019 | Food and environmental virology |
| 31373163 | Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia. | Bănescu C et al. | 2019 | Cancer medicine |
| 31396258 | Host Genetics of Cytomegalovirus Pathogenesis. | Sezgin E et al. | 2019 | Frontiers in genetics |
| 31454695 | Gene polymorphisms and circulating levels of the TNF-alpha are associated with ischemic stroke: A meta-analysis based on 19,873 individuals. | Wu JC et al. | 2019 | International immunopharmacology |
| 31479868 | Association of single nucleotide polymorphisms in TNFA and CCR5 genes with Japanese Encephalitis: A study from an endemic region of North India. | Deval H et al. | 2019 | Journal of neuroimmunology |
| 31594215 | Association between tumor necrosis factor-alpha gene rs1800629 (-308G/A) and rs361525 (-238G > A) polymorphisms and prostate cancer risk in an Iranian cohort. | Alidoost S et al. | 2020 | Human antibodies |
| 31615448 | Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysis. | Zhu S et al. | 2019 | BMC gastroenterology |
| 31624424 | Association of the TNF-<i>α</i> -308G/A polymorphism with lipid profile changes in response to aerobic training program. | Leońska-Duniec A et al. | 2019 | Biology of sport |
| 31652851 | The Association of Serum TNF-α Levels and Blood Multi-Elements Modified by TNF-α Gene Polymorphisms in Metal Industrial Workers. | Chen TH et al. | 2019 | International journal of environmental research and public health |
| 31738572 | Genetic Distribution of the <i>LTA</i> +252 A>G and <i>TNFA</i> -308 G > A Polymorphisms in the Moroccan Population. | Aznag FZ et al. | 2019 | Genetic testing and molecular biomarkers |
| 31816580 | Association between polymorphisms of cytokine genes and brucellosis: A comprehensive systematic review and meta-analysis. | Zafari P et al. | 2020 | Cytokine |
| 31817071 | Polymorphisms in <i>TNF Receptor Superfamily 1B</i> (<i>TNFRSF1B:rs3397</i>) are Linked to <i>Mycobacterium avium paratuberculosis</i> Infection and Osteoporosis in Rheumatoid Arthritis. | Naser A et al. | 2019 | Microorganisms |
| 31819588 | Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case-Control Study. | Al-Eitan LN et al. | 2019 | The application of clinical genetics |
| 31861518 | Genetic Associations with Aging Muscle: A Systematic Review. | Pratt J et al. | 2019 | Cells |
| 31884867 | Association of TNF-<i>α</i> rs1800629, CASP3 rs72689236 and FCGR2A rs1801274 Polymorphisms with Susceptibility to Kawasaki Disease: A Comprehensive Meta-Analysis. | Ferdosian F et al. | 2019 | Fetal and pediatric pathology |
| 31886296 | Impact of SNPs/Haplotypes of <i>IL10</i> and <i>IFNG</i> on the Development of Diffuse Large B-Cell Lymphoma. | Marangon AV et al. | 2019 | Journal of immunology research |
| 31887189 | Important gene-gene interaction of TNF-α and VDR on osteoporosis in community-dwelling elders. | Liao LN et al. | 2019 | PloS one |
| 31912349 | Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder. | Bialek K et al. | 2020 | Cellular and molecular neurobiology |
| 31936215 | Modelling the Effects of MCM7 Variants, Somatic Mutations, and Clinical Features on Acute Myeloid Leukemia Susceptibility and Prognosis. | Tripon F et al. | 2020 | Journal of clinical medicine |
| 31943768 | Association of hepatocellular carcinoma risk with polymorphisms in tumour necrosis factor alpha gene in a Chinese Han population. | Yue X et al. | 2020 | International journal of immunogenetics |
| 31983162 | Association between PSCA, TNF-α, PARP1 and TP53 Gene Polymorphisms and Gastric Cancer Susceptibility in the Brazilian Population. | Dantas RN et al. | 2020 | Asian Pacific journal of cancer prevention |
| 32074604 | Association Analysis of Tumor Necrosis Factor Alpha Promoter Polymorphisms and Vitiligo Susceptibility in South Indian Tamils. | Rajendiran KS et al. | 2020 | Dermatology (Basel, Switzerland) |
| 32083395 | Genetic variants in rheumatic fever and rheumatic heart disease. | Muhamed B et al. | 2020 | American journal of medical genetics. Part C, Seminars in medical genetics |
| 32115620 | Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study. | Yao S et al. | 2020 | The journal of nutrition, health & aging |
| 32124801 | SNPs and transcriptional activity of genes of innate and adaptive immunity at the maternal-fetal interface in woman with preterm labour, associated with preterm premature rupture of membranes. | Lyubomirskaya ES et al. | 2020 | Wiadomosci lekarskie (Warsaw, Poland |
| 32130979 | TNF-α polymorphisms might influence predisposition to periodontitis: A meta-analysis. | Li Y et al. | 2020 | Microbial pathogenesis |
| 32162036 | Genetic polymorphisms and multiple myeloma risk: a meta-analysis. | Zhang P et al. | 2020 | Annals of hematology |
| 32186960 | Study of the association of seventeen single nucleotide polymorphisms and their haplotypes in the <i>TNF-α, IL-2, IL-4</i> and <i>IL-10</i> genes with the antibody response to inactivated Japanese encephalitis vaccine. | Yao Y et al. | 2020 | Human vaccines & immunotherapeutics |
Help
The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.
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Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.