Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs1800629

Current Build 154

Released April 21, 2020

Organism
Homo sapiens
Position
chr6:31575254 (GRCh38.p12) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
G>A
Variation Type
SNV Single Nucleotide Variation
Frequency
A=0.116335 (17554/150892, GnomAD_exome)
A=0.143142 (17974/125568, TOPMED)
A=0.155316 (16999/109448, ALFA Project) (+ 19 more)
A=0.09674 (7613/78698, PAGE_STUDY)
A=0.14683 (4605/31362, GnomAD)
A=0.16159 (3247/20094, ExAC)
A=0.1414 (803/5678, GO-ESP)
A=0.0903 (452/5008, 1000G)
A=0.1672 (749/4480, Estonian)
A=0.1972 (760/3854, ALSPAC)
A=0.1955 (725/3708, TWINSUK)
A=0.0720 (211/2930, KOREAN)
A=0.0851 (161/1892, HapMap)
A=0.192 (192/998, GoNL)
A=0.107 (101/946, PharmGKB)
A=0.175 (105/600, NorthernSweden)
A=0.110 (59/534, MGP)
A=0.213 (46/216, Qatari)
G=0.41 (28/68, SGDP_PRJ)
A=0.17 (7/40, GENOME_DK)
G=0.5 (4/8, Siberian)
A=0.5 (4/8, Siberian)
Clinical Significance
Reported in ClinVar
Gene : Consequence
TNF : 2KB Upstream Variant
Publications
633 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p12 chr 6 NC_000006.12:g.31575254G>A
GRCh37.p13 chr 6 NC_000006.11:g.31543031G>A
TNF RefSeqGene NG_007462.1:g.4682G>A
LTA RefSeqGene NG_012010.1:g.8156G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_COX_CTG1 NT_113891.3:g.3052541A>G
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_COX_CTG1 NT_113891.2:g.3052647A>G
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_MANN_CTG1 NT_167246.2:g.2880295G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MANN_CTG1 NT_167246.1:g.2885915G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1 NT_167249.2:g.2874534G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1 NT_167249.1:g.2873832G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_QBL_CTG1 NT_167248.2:g.2831073G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_QBL_CTG1 NT_167248.1:g.2836669G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_DBB_CTG1 NT_167245.2:g.2822987G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_DBB_CTG1 NT_167245.1:g.2828572G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_MCF_CTG1 NT_167247.2:g.2917152G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MCF_CTG1 NT_167247.1:g.2922737G>A
Gene: TNF, tumor necrosis factor (plus strand) : 2KB Upstream Variant
Molecule type Change Amino acid[Codon] SO Term
TNF transcript NM_000594.4:c. N/A Upstream Transcript Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: A (allele ID: 227757 )
ClinVar Accession Disease Names Clinical Significance
RCV000211242.1 etanercept response - Efficacy Drug-Response
RCV000211284.1 infliximab response - Efficacy Drug-Response
RCV000211408.1 Tumor necrosis factor alpha (TNF-alpha) inhibitors response - Efficacy Drug-Response
RCV000211419.1 adalimumab response - Efficacy Drug-Response

ALFA Allele Frequency (New)
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 260274 G=0.847933 A=0.152067
European Sub 223476 G=0.840730 A=0.159270
African Sub 9072 G=0.8761 A=0.1239
African Others Sub 312 G=0.881 A=0.119
African American Sub 8760 G=0.8759 A=0.1241
Asian Sub 6664 G=0.9275 A=0.0725
East Asian Sub 4806 G=0.9247 A=0.0753
Other Asian Sub 1858 G=0.9349 A=0.0651
Latin American 1 Sub 584 G=0.875 A=0.125
Latin American 2 Sub 5366 G=0.9152 A=0.0848
South Asian Sub 324 G=0.907 A=0.093
Other Sub 14788 G=0.87686 A=0.12314


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
gnomAD - Exomes Global Study-wide 150892 G=0.883665 A=0.116335
gnomAD - Exomes European Sub 69496 G=0.84058 A=0.15942
gnomAD - Exomes Asian Sub 34862 G=0.91937 A=0.08063
gnomAD - Exomes American Sub 25616 G=0.94058 A=0.05942
gnomAD - Exomes Ashkenazi Jewish Sub 8522 G=0.9238 A=0.0762
gnomAD - Exomes African Sub 7930 G=0.8815 A=0.1185
gnomAD - Exomes Other Sub 4466 G=0.8762 A=0.1238
TopMed Global Study-wide 125568 G=0.856858 A=0.143142
ALFA Total Global 109448 G=0.844684 A=0.155316
ALFA European Sub 93626 G=0.83763 A=0.16237
ALFA Other Sub 6882 G=0.8714 A=0.1286
ALFA African Sub 4618 G=0.8826 A=0.1174
ALFA Latin American 2 Sub 4156 G=0.9141 A=0.0859
ALFA Latin American 1 Sub 82 G=0.89 A=0.11
ALFA Asian Sub 80 G=0.95 A=0.05
ALFA South Asian Sub 4 G=1.0 A=0.0
The PAGE Study Global Study-wide 78698 G=0.90326 A=0.09674
The PAGE Study AfricanAmerican Sub 32516 G=0.87249 A=0.12751
The PAGE Study Mexican Sub 10808 G=0.93338 A=0.06662
The PAGE Study Asian Sub 8316 G=0.9756 A=0.0244
The PAGE Study PuertoRican Sub 7918 G=0.9057 A=0.0943
The PAGE Study NativeHawaiian Sub 4534 G=0.9285 A=0.0715
The PAGE Study Cuban Sub 4230 G=0.8823 A=0.1177
The PAGE Study Dominican Sub 3828 G=0.8824 A=0.1176
The PAGE Study CentralAmerican Sub 2450 G=0.9327 A=0.0673
The PAGE Study SouthAmerican Sub 1982 G=0.9289 A=0.0711
The PAGE Study NativeAmerican Sub 1260 G=0.8754 A=0.1246
The PAGE Study SouthAsian Sub 856 G=0.928 A=0.072
gnomAD - Genomes Global Study-wide 31362 G=0.85317 A=0.14683
gnomAD - Genomes European Sub 18886 G=0.83623 A=0.16377
gnomAD - Genomes African Sub 8704 G=0.8743 A=0.1257
gnomAD - Genomes East Asian Sub 1550 G=0.9110 A=0.0890
gnomAD - Genomes Other Sub 1084 G=0.8321 A=0.1679
gnomAD - Genomes American Sub 848 G=0.921 A=0.079
gnomAD - Genomes Ashkenazi Jewish Sub 290 G=0.893 A=0.107
ExAC Global Study-wide 20094 G=0.83841 A=0.16159
ExAC Europe Sub 9500 G=0.7780 A=0.2220
ExAC Asian Sub 8566 G=0.9075 A=0.0925
ExAC African Sub 1294 G=0.8060 A=0.1940
ExAC American Sub 554 G=0.868 A=0.132
ExAC Other Sub 180 G=0.878 A=0.122
GO Exome Sequencing Project Global Study-wide 5678 G=0.8586 A=0.1414
GO Exome Sequencing Project European American Sub 3944 G=0.8494 A=0.1506
GO Exome Sequencing Project African American Sub 1734 G=0.8795 A=0.1205
1000Genomes Global Study-wide 5008 G=0.9097 A=0.0903
1000Genomes African Sub 1322 G=0.8805 A=0.1195
1000Genomes East Asian Sub 1008 G=0.9415 A=0.0585
1000Genomes Europe Sub 1006 G=0.8658 A=0.1342
1000Genomes South Asian Sub 978 G=0.947 A=0.053
1000Genomes American Sub 694 G=0.931 A=0.069
Genetic variation in the Estonian population Estonian Study-wide 4480 G=0.8328 A=0.1672
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 G=0.8028 A=0.1972
UK 10K study - Twins TWIN COHORT Study-wide 3708 G=0.8045 A=0.1955
KOREAN population from KRGDB KOREAN Study-wide 2930 G=0.9280 A=0.0720
HapMap Global Study-wide 1892 G=0.9149 A=0.0851
HapMap American Sub 770 G=0.912 A=0.088
HapMap African Sub 692 G=0.913 A=0.087
HapMap Asian Sub 254 G=0.937 A=0.063
HapMap Europe Sub 176 G=0.903 A=0.097
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 G=0.808 A=0.192
PharmGKB Aggregated Global Study-wide 946 G=0.893 A=0.107
PharmGKB Aggregated PA135299591 Sub 946 G=0.893 A=0.107
Northern Sweden ACPOP Study-wide 600 G=0.825 A=0.175
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 G=0.890 A=0.110
Qatari Global Study-wide 216 G=0.787 A=0.213
SGDP_PRJ Global Study-wide 68 G=0.41 A=0.59
The Danish reference pan genome Danish Study-wide 40 G=0.82 A=0.17
Siberian Global Study-wide 8 G=0.5 A=0.5
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement G= A
GRCh38.p12 chr 6 NC_000006.12:g.31575254= NC_000006.12:g.31575254G>A
GRCh37.p13 chr 6 NC_000006.11:g.31543031= NC_000006.11:g.31543031G>A
TNF RefSeqGene NG_007462.1:g.4682= NG_007462.1:g.4682G>A
LTA RefSeqGene NG_012010.1:g.8156= NG_012010.1:g.8156G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_COX_CTG1 NT_113891.3:g.3052541A>G NT_113891.3:g.3052541=
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_COX_CTG1 NT_113891.2:g.3052647A>G NT_113891.2:g.3052647=
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_MANN_CTG1 NT_167246.2:g.2880295= NT_167246.2:g.2880295G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MANN_CTG1 NT_167246.1:g.2885915= NT_167246.1:g.2885915G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1 NT_167249.2:g.2874534= NT_167249.2:g.2874534G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1 NT_167249.1:g.2873832= NT_167249.1:g.2873832G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_QBL_CTG1 NT_167248.2:g.2831073= NT_167248.2:g.2831073G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_QBL_CTG1 NT_167248.1:g.2836669= NT_167248.1:g.2836669G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_DBB_CTG1 NT_167245.2:g.2822987= NT_167245.2:g.2822987G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_DBB_CTG1 NT_167245.1:g.2828572= NT_167245.1:g.2828572G>A
GRCh38.p12 chr 6 alt locus HSCHR6_MHC_MCF_CTG1 NT_167247.2:g.2917152= NT_167247.2:g.2917152G>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MCF_CTG1 NT_167247.1:g.2922737= NT_167247.1:g.2922737G>A
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

130 SubSNP, 21 Frequency, 4 ClinVar submissions
No Submitter Submission ID Date (Build)
1 HGBASE ss2420741 Nov 14, 2000 (89)
2 PGA-UW-FHCRC ss4328930 Mar 26, 2002 (106)
3 SC_JCM ss4377317 Mar 26, 2002 (106)
4 SNP500CANCER ss5586943 Jul 02, 2003 (116)
5 EGP_SNPS ss6310583 Feb 20, 2003 (111)
6 EGP_SNPS ss6312900 Feb 20, 2003 (111)
7 SI_MHC_SNP ss12691494 Oct 31, 2003 (118)
8 FHCRC ss16360688 Feb 27, 2004 (120)
9 FHCRC ss16360736 Feb 27, 2004 (120)
10 STEJUSTINE-REGGEN ss51854703 Mar 16, 2006 (126)
11 PGA-UW-FHCRC ss52088979 Oct 15, 2006 (127)
12 KRIBB_YJKIM ss65843449 Nov 30, 2006 (127)
13 EGP_SNPS ss66857511 Nov 30, 2006 (127)
14 EGP_SNPS ss66859809 Nov 30, 2006 (127)
15 PERLEGEN ss68971678 May 17, 2007 (127)
16 PHARMGKB_PARC ss69366252 May 17, 2007 (127)
17 ILLUMINA ss75254821 Dec 07, 2007 (129)
18 CGM_KYOTO ss76873614 Dec 07, 2007 (129)
19 HGSV ss80949408 Dec 15, 2007 (130)
20 HURLEY-POSCH-LAB ss86217651 Mar 23, 2008 (129)
21 SHGC ss95216268 Feb 05, 2009 (130)
22 BGI ss104296823 Dec 01, 2009 (131)
23 1000GENOMES ss109901711 Feb 13, 2009 (130)
24 ILLUMINA-UK ss116394700 Feb 14, 2009 (130)
25 GMI ss156747688 Dec 01, 2009 (131)
26 ILLUMINA ss160462872 Dec 01, 2009 (131)
27 COMPLETE_GENOMICS ss162198777 Jul 04, 2010 (132)
28 ILLUMINA ss172924883 Jul 04, 2010 (132)
29 BUSHMAN ss201626002 Jul 04, 2010 (132)
30 1000GENOMES ss222304163 Jul 14, 2010 (132)
31 1000GENOMES ss233399218 Jul 14, 2010 (132)
32 1000GENOMES ss240469923 Jul 15, 2010 (132)
33 ILLUMINA ss244285039 Jul 04, 2010 (132)
34 BL ss254187389 May 09, 2011 (137)
35 GMI ss278727093 May 04, 2012 (137)
36 GMI ss285374156 Apr 25, 2013 (138)
37 ILLUMINA ss410916050 Sep 17, 2011 (137)
38 ILLUMINA ss480300551 May 04, 2012 (137)
39 ILLUMINA ss480311656 May 04, 2012 (137)
40 ILLUMINA ss481067278 Sep 08, 2015 (146)
41 ILLUMINA ss484948088 May 04, 2012 (137)
42 EXOME_CHIP ss491381906 May 04, 2012 (137)
43 ILLUMINA ss536992328 Sep 08, 2015 (146)
44 SSMP ss653035581 Apr 25, 2013 (138)
45 NHLBI-ESP ss712699264 Apr 25, 2013 (138)
46 ILLUMINA ss778467783 Sep 08, 2015 (146)
47 ILLUMINA ss780682574 Sep 08, 2015 (146)
48 ILLUMINA ss782920352 Sep 08, 2015 (146)
49 ILLUMINA ss783355928 Sep 08, 2015 (146)
50 ILLUMINA ss783883384 Sep 08, 2015 (146)
51 ILLUMINA ss832175477 Sep 08, 2015 (146)
52 ILLUMINA ss833923542 Sep 08, 2015 (146)
53 JMKIDD_LAB ss974459603 Aug 21, 2014 (142)
54 EVA-GONL ss982766421 Aug 21, 2014 (142)
55 JMKIDD_LAB ss1067477166 Aug 21, 2014 (142)
56 JMKIDD_LAB ss1073506038 Aug 21, 2014 (142)
57 1000GENOMES ss1319558829 Aug 21, 2014 (142)
58 EVA_GENOME_DK ss1581606820 Apr 01, 2015 (144)
59 EVA_DECODE ss1592310303 Apr 01, 2015 (144)
60 EVA_UK10K_ALSPAC ss1615278019 Apr 01, 2015 (144)
61 EVA_UK10K_TWINSUK ss1658272052 Apr 01, 2015 (144)
62 EVA_EXAC ss1688230716 Apr 01, 2015 (144)
63 EVA_MGP ss1711121135 Apr 01, 2015 (144)
64 EVA_SVP ss1712851078 Apr 01, 2015 (144)
65 ILLUMINA ss1752628691 Sep 08, 2015 (146)
66 ILLUMINA ss1752628692 Sep 08, 2015 (146)
67 ILLUMINA ss1917802451 Feb 12, 2016 (147)
68 WEILL_CORNELL_DGM ss1926018780 Feb 12, 2016 (147)
69 ILLUMINA ss1946173378 Feb 12, 2016 (147)
70 ILLUMINA ss1958888381 Feb 12, 2016 (147)
71 JJLAB ss2023642576 Sep 14, 2016 (149)
72 ILLUMINA ss2094824801 Dec 20, 2016 (150)
73 ILLUMINA ss2095178036 Dec 20, 2016 (150)
74 USC_VALOUEV ss2151809013 Dec 20, 2016 (150)
75 HUMAN_LONGEVITY ss2282946228 Dec 20, 2016 (150)
76 TOPMED ss2451321803 Dec 20, 2016 (150)
77 SYSTEMSBIOZJU ss2626308723 Nov 08, 2017 (151)
78 ILLUMINA ss2634429968 Nov 08, 2017 (151)
79 ILLUMINA ss2635155642 Nov 08, 2017 (151)
80 GRF ss2707402813 Nov 08, 2017 (151)
81 ILLUMINA ss2711069578 Nov 08, 2017 (151)
82 GNOMAD ss2735648837 Nov 08, 2017 (151)
83 GNOMAD ss2747581793 Nov 08, 2017 (151)
84 GNOMAD ss2837428886 Nov 08, 2017 (151)
85 AFFY ss2985362252 Nov 08, 2017 (151)
86 AFFY ss2985994164 Nov 08, 2017 (151)
87 SWEGEN ss2998796491 Nov 08, 2017 (151)
88 ILLUMINA ss3022599572 Nov 08, 2017 (151)
89 BIOINF_KMB_FNS_UNIBA ss3025608431 Nov 08, 2017 (151)
90 TOPMED ss3493847195 Nov 08, 2017 (151)
91 ILLUMINA ss3625897843 Oct 12, 2018 (152)
92 ILLUMINA ss3629503652 Oct 12, 2018 (152)
93 ILLUMINA ss3629503653 Oct 12, 2018 (152)
94 ILLUMINA ss3632348527 Oct 12, 2018 (152)
95 ILLUMINA ss3633415350 Oct 12, 2018 (152)
96 ILLUMINA ss3634137836 Oct 12, 2018 (152)
97 ILLUMINA ss3635057013 Oct 12, 2018 (152)
98 ILLUMINA ss3635057014 Oct 12, 2018 (152)
99 ILLUMINA ss3635818854 Oct 12, 2018 (152)
100 ILLUMINA ss3636778275 Oct 12, 2018 (152)
101 ILLUMINA ss3637571638 Oct 12, 2018 (152)
102 ILLUMINA ss3638619862 Oct 12, 2018 (152)
103 ILLUMINA ss3640764312 Oct 12, 2018 (152)
104 ILLUMINA ss3640764313 Oct 12, 2018 (152)
105 ILLUMINA ss3643561243 Oct 12, 2018 (152)
106 ILLUMINA ss3644906437 Oct 12, 2018 (152)
107 OMUKHERJEE_ADBS ss3646334755 Oct 12, 2018 (152)
108 ILLUMINA ss3653112183 Oct 12, 2018 (152)
109 ILLUMINA ss3653112184 Oct 12, 2018 (152)
110 ILLUMINA ss3654128111 Oct 12, 2018 (152)
111 KU-SAB ss3654261673 Oct 12, 2018 (152)
112 EGCUT_WGS ss3666710812 Jul 13, 2019 (153)
113 EVA_DECODE ss3716909250 Jul 13, 2019 (153)
114 ILLUMINA ss3726330083 Jul 13, 2019 (153)
115 ACPOP ss3733362133 Jul 13, 2019 (153)
116 ILLUMINA ss3744549890 Jul 13, 2019 (153)
117 ILLUMINA ss3745357013 Jul 13, 2019 (153)
118 ILLUMINA ss3745357014 Jul 13, 2019 (153)
119 EVA ss3764822995 Jul 13, 2019 (153)
120 PAGE_CC ss3771278957 Jul 13, 2019 (153)
121 ILLUMINA ss3772850714 Jul 13, 2019 (153)
122 ILLUMINA ss3772850715 Jul 13, 2019 (153)
123 KHV_HUMAN_GENOMES ss3807978245 Jul 13, 2019 (153)
124 EVA ss3824170220 Apr 26, 2020 (154)
125 EVA ss3825694226 Apr 26, 2020 (154)
126 EVA ss3829833058 Apr 26, 2020 (154)
127 EVA ss3838394885 Apr 26, 2020 (154)
128 EVA ss3843837070 Apr 26, 2020 (154)
129 SGDP_PRJ ss3864255581 Apr 26, 2020 (154)
130 KRGDB ss3911030497 Apr 26, 2020 (154)
131 1000Genomes NC_000006.11 - 31543031 Oct 12, 2018 (152)
132 The Avon Longitudinal Study of Parents and Children NC_000006.11 - 31543031 Oct 12, 2018 (152)
133 Genetic variation in the Estonian population NC_000006.11 - 31543031 Oct 12, 2018 (152)
134 ExAC NC_000006.11 - 31543031 Oct 12, 2018 (152)
135 The Danish reference pan genome NC_000006.11 - 31543031 Apr 26, 2020 (154)
136 gnomAD - Genomes NC_000006.11 - 31543031 Jul 13, 2019 (153)
137 gnomAD - Exomes NC_000006.11 - 31543031 Jul 13, 2019 (153)
138 GO Exome Sequencing Project NC_000006.11 - 31543031 Oct 12, 2018 (152)
139 Genome of the Netherlands Release 5 NC_000006.11 - 31543031 Apr 26, 2020 (154)
140 HapMap NC_000006.12 - 31575254 Apr 26, 2020 (154)
141 KOREAN population from KRGDB NC_000006.11 - 31543031 Apr 26, 2020 (154)
142 Medical Genome Project healthy controls from Spanish population NC_000006.11 - 31543031 Apr 26, 2020 (154)
143 Northern Sweden NC_000006.11 - 31543031 Jul 13, 2019 (153)
144 The PAGE Study NC_000006.12 - 31575254 Jul 13, 2019 (153)
145 PharmGKB Aggregated NC_000006.12 - 31575254 Apr 26, 2020 (154)
146 Qatari NC_000006.11 - 31543031 Apr 26, 2020 (154)
147 SGDP_PRJ NC_000006.11 - 31543031 Apr 26, 2020 (154)
148 Siberian NC_000006.11 - 31543031 Apr 26, 2020 (154)
149 TopMed NC_000006.12 - 31575254 Oct 12, 2018 (152)
150 UK 10K study - Twins NC_000006.11 - 31543031 Oct 12, 2018 (152)
151 dbGaP Population Frequency Project NC_000006.12 - 31575254 Apr 26, 2020 (154)
152 ClinVar RCV000211242.1 Oct 12, 2018 (152)
153 ClinVar RCV000211284.1 Oct 12, 2018 (152)
154 ClinVar RCV000211408.1 Oct 12, 2018 (152)
155 ClinVar RCV000211419.1 Oct 12, 2018 (152)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs3091256 Jul 03, 2002 (106)
rs4134777 Nov 14, 2002 (109)
rs36205298 Oct 25, 2006 (127)
rs59729336 May 25, 2008 (130)
rs116610137 Oct 26, 2010 (133)
rs117441802 Aug 16, 2010 (132)
rs148958203 May 04, 2012 (137)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss80949408 NC_000006.9:31651009:G:A NC_000006.12:31575253:G:A (self)
ss109901711, ss116394700, ss162198777, ss201626002, ss254187389, ss278727093, ss285374156, ss480300551, ss1592310303, ss1712851078, ss2635155642, ss3643561243 NC_000006.10:31651009:G:A NC_000006.12:31575253:G:A (self)
31326286, 17467583, 12449060, 8256040, 7771759, 85675752, 4791395, 628263, 7765195, 18207891, 236895, 6646998, 8060710, 16272561, 4325367, 17467583, ss222304163, ss233399218, ss240469923, ss480311656, ss481067278, ss484948088, ss491381906, ss536992328, ss653035581, ss712699264, ss778467783, ss780682574, ss782920352, ss783355928, ss783883384, ss832175477, ss833923542, ss974459603, ss982766421, ss1067477166, ss1073506038, ss1319558829, ss1581606820, ss1615278019, ss1658272052, ss1688230716, ss1711121135, ss1752628691, ss1752628692, ss1917802451, ss1926018780, ss1946173378, ss1958888381, ss2023642576, ss2094824801, ss2095178036, ss2151809013, ss2451321803, ss2626308723, ss2634429968, ss2707402813, ss2711069578, ss2735648837, ss2747581793, ss2837428886, ss2985362252, ss2985994164, ss2998796491, ss3022599572, ss3625897843, ss3629503652, ss3629503653, ss3632348527, ss3633415350, ss3634137836, ss3635057013, ss3635057014, ss3635818854, ss3636778275, ss3637571638, ss3638619862, ss3640764312, ss3640764313, ss3644906437, ss3646334755, ss3653112183, ss3653112184, ss3654128111, ss3666710812, ss3733362133, ss3744549890, ss3745357013, ss3745357014, ss3764822995, ss3772850714, ss3772850715, ss3824170220, ss3825694226, ss3829833058, ss3838394885, ss3864255581, ss3911030497 NC_000006.11:31543030:G:A NC_000006.12:31575253:G:A (self)
RCV000211242.1, RCV000211284.1, RCV000211408.1, RCV000211419.1, 3100211, 500426, 10675, 335045729, 413541372, ss2282946228, ss3025608431, ss3493847195, ss3654261673, ss3716909250, ss3726330083, ss3771278957, ss3807978245, ss3843837070 NC_000006.12:31575253:G:A NC_000006.12:31575253:G:A (self)
ss2420741, ss4328930, ss4377317, ss5586943, ss6310583, ss6312900, ss12691494, ss16360688, ss16360736, ss51854703, ss52088979, ss65843449, ss66857511, ss66859809, ss68971678, ss69366252, ss75254821, ss76873614, ss86217651, ss95216268, ss104296823, ss156747688, ss160462872, ss172924883, ss244285039, ss410916050 NT_007592.15:31483030:G:A NC_000006.12:31575253:G:A (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

633 citations for rs1800629
PMID Title Author Year Journal
12190096 A positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism. Louis E et al. 2002 Scandinavian journal of gastroenterology
12759288 Genetic markers for the efficacy of tumour necrosis factor blocking therapy in rheumatoid arthritis. Padyukov L et al. 2003 Annals of the rheumatic diseases
12847678 Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis. Mugnier B et al. 2003 Arthritis and rheumatism
15726497 Gene-environment interaction effects on the development of immune responses in the 1st year of life. Hoffjan S et al. 2005 American journal of human genetics
15797957 Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women. Moffett SP et al. 2005 The Journal of clinical endocrinology and metabolism
15817713 Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Hersh CP et al. 2005 American journal of respiratory cell and molecular biology
15834068 Polymorphism at position -308 of the tumour necrosis factor alpha gene and rheumatoid arthritis pharmacogenetics. Fonseca JE et al. 2005 Annals of the rheumatic diseases
15895461 TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels. Laws SM et al. 2005 Human mutation
16046815 Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes. Wren JD et al. 2005 Journal of biomedicine & biotechnology
16385446 A testing framework for identifying susceptibility genes in the presence of epistasis. Millstein J et al. 2006 American journal of human genetics
16449530 Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. Lan Q et al. 2006 Blood
16617143 Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data. Callegaro A et al. 2006 Nucleic acids research
16672072 The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome. Chong WP et al. 2006 BMC infectious diseases
16720636 The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients. Seitz M et al. 2007 Rheumatology (Oxford, England)
16759385 Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA). Imboden M et al. 2006 Clinical and molecular allergy
16820586 Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Podgoreanu MV et al. 2006 Circulation
16846490 Lemierre's syndrome and genetic polymorphisms: a case report. Constantin JM et al. 2006 BMC infectious diseases
16872485 Three allele combinations associated with multiple sclerosis. Favorova OO et al. 2006 BMC medical genetics
16909270 Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. Lee YH et al. 2006 Rheumatology international
17018637 Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphoma. Wang SS et al. 2006 Cancer research
17054776 The genetics of chronic obstructive pulmonary disease. Wood AM et al. 2006 Respiratory research
17174749 Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility. Noble JA et al. 2006 Human immunology
17216494 Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk. Gaudet MM et al. 2007 Human genetics
17327408 Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Cerhan JR et al. 2007 Blood
17343250 Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. Cuchacovich M et al. 2006 Scandinavian journal of rheumatology
17450233 Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma. Wu H et al. 2007 Environmental health perspectives
17510437 Immune mechanisms in non-Hodgkin lymphoma: joint effects of the TNF G308A and IL10 T3575A polymorphisms with non-Hodgkin lymphoma risk factors. Wang SS et al. 2007 Cancer research
17668374 Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. Ayodo G et al. 2007 American journal of human genetics
17673491 A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis. Miceli-Richard C et al. 2008 Annals of the rheumatic diseases
17701899 Flexible design for following up positive findings. Yu K et al. 2007 American journal of human genetics
17705862 Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples. Pullat J et al. 2007 BMC genomics
18041006 Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. Pereira FA et al. 2008 Journal of medical virology
18050183 Influence of -308 A/G polymorphism in the tumor necrosis factor alpha gene on etanercept treatment in rheumatoid arthritis. Guis S et al. 2007 Arthritis and rheumatism
18194515 Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population. Sinha S et al. 2008 Malaria journal
18196539 TNF polymorphisms and prostate cancer risk. Danforth KN et al. 2008 The Prostate
18307517 Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans. Taudorf S et al. 2008 Clinical and experimental immunology
18319718 Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis. Gorouhi F et al. 2008 British journal of cancer
18398712 No association found between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes. Wang N et al. 2008 Current eye research
18423522 Estimating odds ratios in genome scans: an approximate conditional likelihood approach. Ghosh A et al. 2008 American journal of human genetics
18426866 Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Marvelle AF et al. 2008 Diabetes
18434886 Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor. Menges T et al. 2008 Critical care medicine
18438841 Association between the level of circulating bioactive tumor necrosis factor alpha and the tumor necrosis factor alpha gene polymorphism at -308 in patients with rheumatoid arthritis treated with a tumor necrosis factor alpha inhibitor. Marotte H et al. 2008 Arthritis and rheumatism
18513389 New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. Penco S et al. 2008 BMC bioinformatics
18515978 Association of tumor necrosis factor -308G/A promoter polymorphism with schizophrenia and bipolar affective disorder in a Polish population. Czerski PM et al. 2008 Neuropsychobiology
18520591 Sequence variants in host cell factor C1 are associated with Ménière's disease. Vrabec JT et al. 2008 Otology & neurotology
18551993 SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women. Lin GT et al. 2008 The Chinese journal of physiology
18575614 Association between LTA, TNF and AGER polymorphisms and late diabetic complications. Lindholm E et al. 2008 PloS one
18603647 Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response. Simoni M et al. 2008 Human reproduction update
18615156 Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. Liu C et al. 2008 Molecular medicine (Cambridge, Mass.)
18620570 The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency. Wood AM et al. 2008 Respiratory research
18633131 Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era. Habermann TM et al. 2008 Blood
18635873 TNF promoter polymorphisms associated with muscle phenotypes in humans. Liu D et al. 2008 Journal of applied physiology (Bethesda, Md.
18640487 Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation. Israni AK et al. 2008 American journal of kidney diseases
18676870 Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. Hsing AW et al. 2008 Cancer research
18698679 Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk. Ferguson LR et al. 2008 World journal of gastroenterology
18709160 Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Melén E et al. 2008 Environmental health perspectives
18713756 Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. Maxwell JR et al. 2008 Human molecular genetics
18715339 Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. Dhiman N et al. 2008 Tissue antigens
18796628 Etiologic heterogeneity among non-Hodgkin lymphoma subtypes. Morton LM et al. 2008 Blood
18805939 Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis. Tempfer CB et al. 2009 Human reproduction update
18811622 Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma. Puthothu B et al. 2009 Pediatric allergy and immunology
18936436 Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Chang MH et al. 2009 American journal of epidemiology
18990758 Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. Cerhan JR et al. 2008 Cancer epidemiology, biomarkers & prevention
19035456 Adipokine genes and prostate cancer risk. Moore SC et al. 2009 International journal of cancer
19035492 Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis. Mamyrova G et al. 2008 Arthritis and rheumatism
19039607 A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility. Diakite M et al. 2009 Human genetics
19066394 Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. Colt JS et al. 2009 Blood
19126646 Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA. Ognjanovic S et al. 2009 Carcinogenesis
19131662 A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Wang X et al. 2009 Stroke
19147066 Genomic and proteomic analysis of allogeneic hematopoietic cell transplant outcome. Seeking greater understanding the pathogenesis of GVHD and mortality. Hansen JA et al. 2009 Biology of blood and marrow transplantation
19167443 Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia. Boraska V et al. 2009 Human immunology
19225544 Variation in the lymphotoxin-alpha/tumor necrosis factor locus modifies risk of erythema nodosum in sarcoidosis. McDougal KE et al. 2009 The Journal of investigative dermatology
19233472 Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection. Chen Y et al. 2009 Molecular immunology
19263529 Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. Zee RY et al. 2009 Clinica chimica acta; international journal of clinical chemistry
19279689 TNF-alpha -308 G>A and -238 G>A polymorphisms are not major risk factors in Caucasian patients with exfoliation glaucoma. Mossböck G et al. 2009 Molecular vision
19281305 Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. Clark TG et al. 2009 The Journal of infectious diseases
19330901 Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. Conen D et al. 2009 Journal of hypertension
19347053 Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion. Steinbrugger I et al. 2009 Molecular vision
19356949 Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies. Van Dyke AL et al. 2009 Cytokine
19365401 TNF-alpha-308 G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis. O'Rielly DD et al. 2009 The pharmacogenomics journal
19386798 Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever. Forte GI et al. 2009 Clinical and vaccine immunology
19401444 Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism. Martínez-García MA et al. 2009 Diabetes care
19405090 Genetic polymorphisms in chronic hyperplastic sinusitis with nasal polyposis. Bernstein JM et al. 2009 The Laryngoscope
19409079 Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study. Kirsten H et al. 2009 Arthritis research & therapy
19419979 Preliminary evidence of a genetic association between tumor necrosis factor alpha and the severity of sleep disturbance and morning fatigue. Aouizerat BE et al. 2009 Biological research for nursing
19438866 Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk. Gu F et al. 2009 The British journal of dermatology
19478423 Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levels. Belisle SE et al. 2008 BioFactors (Oxford, England)
19505919 Toll-like receptor signaling pathway variants and prostate cancer mortality. Stark JR et al. 2009 Cancer epidemiology, biomarkers & prevention
19559392 A candidate gene association study of 77 polymorphisms in migraine. Schürks M et al. 2009 The journal of pain
19615068 The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study. Yang JJ et al. 2009 BMC cancer
19654554 The major histocompatibility complex conserved extended haplotype 8.1 in AIDS-related non-Hodgkin lymphoma. Aissani B et al. 2009 Journal of acquired immune deficiency syndromes (1999)
19661089 Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. Hussain SK et al. 2009 Cancer epidemiology, biomarkers & prevention
19673019 IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location. Sanchez R et al. 2009 World journal of gastroenterology
19700502 Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system. Zintzaras E et al. 2009 American journal of epidemiology
19732761 Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves' disease. Gu LQ et al. 2010 Clinical biochemistry
19773451 Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Reyes-Gibby CC et al. 2009 Cancer epidemiology, biomarkers & prevention
19933216 The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Castaldi PJ et al. 2010 Human molecular genetics
19934104 Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. Attur M et al. 2010 Annals of the rheumatic diseases
19951401 Chronic obstructive pulmonary disease: towards pharmacogenetics. Wood AM et al. 2009 Genome medicine
20007930 A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations. Möller M et al. 2010 American journal of respiratory and critical care medicine
20012999 The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer. Jatoi A et al. 2010 Supportive care in cancer
20031567 An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study. Zee RY et al. 2009 Circulation. Cardiovascular genetics
20047977 Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium. Skibola CF et al. 2010 American journal of epidemiology
20049212 Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS). Castro-Giner F et al. 2009 Environmental health perspectives
20080841 Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components. Phillips CM et al. 2010 The Journal of clinical endocrinology and metabolism
20083555 Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians. Dato S et al. 2010 The journals of gerontology. Series A, Biological sciences and medical sciences
20087644 Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma. Fernberg P et al. 2010 Cancer causes & control
20112337 Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers. Oh SS et al. 2010 International journal of cancer
20113413 Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation. Yilmaz IA et al. 2010 Pain medicine (Malden, Mass.)
20132806 Study of TNFalpha -308G/A and IL6 -174G/C polymorphisms in type 2 diabetes and obesity risk in the Tunisian population. Bouhaha R et al. 2010 Clinical biochemistry
20157068 Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study. Mfuna Endam L et al. 2010 Archives of otolaryngology--head & neck surgery
20177654 Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians. Mahajan A et al. 2010 Journal of molecular medicine (Berlin, Germany)
20206339 Tumor necrosis factor alpha gene variants do not display allelic imbalance in circulating myeloid cells. Wienzek S et al. 2010 Cellular immunology
20227257 Polymorphisms in the platelet-specific collagen receptor GP6 are associated with risk of nonfatal myocardial infarction in Caucasians. Shaffer JR et al. 2011 Nutrition, metabolism, and cardiovascular diseases
20357201 Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. Fan BJ et al. 2010 Investigative ophthalmology & visual science
20357209 Molecular genetic studies of gene identification for osteoporosis: the 2009 update. Xu XH et al. 2010 Endocrine reviews
20361391 The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study. Kilpeläinen TO et al. 2010 Experimental and clinical endocrinology & diabetes
20396431 Genotyping sleep disorders patients. Kripke DF et al. 2010 Psychiatry investigation
20401335 Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype. Driss A et al. 2009 Genomics insights
20417488 Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years. Clark EA et al. 2010 American journal of obstetrics and gynecology
20418110 Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer. Erdei E et al. 2010 Cytokine
20431935 Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk. Zhang J et al. 2010 Cancer causes & control
20459604 Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes. Boraska V et al. 2010 BMC medical genetics
20461113 A screening methodology based on Random Forests to improve the detection of gene-gene interactions. De Lobel L et al. 2010 European journal of human genetics
20463618 Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Abu-Maziad A et al. 2010 Pediatric research
20473875 Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians. Zabaleta J et al. 2011 International journal of cancer
20564140 Relationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors. Rausch SM et al. 2010 Cancer
20565774 Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project. Cross DS et al. 2010 BMC genetics
20570482 Preliminary evidence of an association between a functional interleukin-6 polymorphism and fatigue and sleep disturbance in oncology patients and their family caregivers. Miaskowski C et al. 2010 Journal of pain and symptom management
20578265 Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction. Juran BD et al. 2010 Hepatology (Baltimore, Md.)
20605164 Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis. Niewold TB et al. 2010 The Journal of pediatrics
20638243 Update on the genetics and genomics of PBC. Juran BD et al. 2010 Journal of autoimmunity
20639881 Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Conde L et al. 2010 Nature genetics
20650301 Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. Sapkota BR et al. 2010 Human immunology
20662065 Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. Clancy RM et al. 2010 Arthritis and rheumatism
20668555 Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity. Ovsyannikova IG et al. 2010 PloS one
20682333 Associations between the tumor necrosis factor alpha gene (-308G→A) and event-related potential indices of attention and mental rotation. Beste C et al. 2010 Neuroscience
20693638 An association study of 21 potential Alzheimer's disease risk genes in a Finnish population. Sarajärvi T et al. 2010 Journal of Alzheimer's disease
20711808 Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists. Schonfeld SJ et al. 2010 Cancer causes & control
20725607 CCL3 genotype and current depression increase risk of HIV-associated dementia. Levine AJ et al. 2009 Neurobehavioral HIV medicine
20796230 Tumour necrosis factor-alpha gene polymorphisms and susceptibility to oral lichen planus. Kimkong I et al. 2011 Oral diseases
20810691 Variations in the TNF-α gene (TNF-α -308G→A) affect attention and action selection mechanisms in a dissociated fashion. Beste C et al. 2010 Journal of neurophysiology
20811626 Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA et al. 2010 PloS one
20816195 Analyses of shared genetic factors between asthma and obesity in children. Melén E et al. 2010 The Journal of allergy and clinical immunology
20827186 Defining genetic risk for graft-versus-host disease and mortality following allogeneic hematopoietic stem cell transplantation. Hansen JA et al. 2010 Current opinion in hematology
20846669 TNF-α gene polymorphisms and excessive daytime sleepiness in pediatric obstructive sleep apnea. Khalyfa A et al. 2011 The Journal of pediatrics
20878356 Role of ethnic variations in TNF-α and TNF-β polymorphisms and risk of breast cancer in India. Pooja S et al. 2011 Breast cancer research and treatment
20923569 Associations between SNPs in candidate immune-relevant genes and rubella antibody levels: a multigenic assessment. Pankratz VS et al. 2010 BMC immunology
20952689 Cytokine polymorphisms in Th1/Th2 pathway genes, body mass index, and risk of non-Hodgkin lymphoma. Chen Y et al. 2011 Blood
20965572 Interplay of cytokine polymorphisms and bacterial vaginosis in the etiology of preterm delivery. Jones NM et al. 2010 Journal of reproductive immunology
21029472 A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults. Randall LM et al. 2010 Malaria journal
21039421 Treatment of rheumatoid arthritis with tumour necrosis factor inhibitors. Mewar D et al. 2011 British journal of pharmacology
21054877 Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994. Ned RM et al. 2010 BMC medical genetics
21080879 A study of TNF-alpha-238 and -308 polymorphisms with different outcomes of persistent hepatitis B virus infection in China. Wang B et al. 2010 Pathology
21085187 Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. Birlea SA et al. 2011 The Journal of investigative dermatology
21103062 Unifying candidate gene and GWAS Approaches in Asthma. Michel S et al. 2010 PloS one
21148756 Variations in chromosomes 9 and 6p21.3 with risk of non-Hodgkin lymphoma. Wang SS et al. 2011 Cancer epidemiology, biomarkers & prevention
21149504 Common variations in the genes encoding C-reactive protein, tumor necrosis factor-alpha, and interleukin-6, and the risk of clinical diabetes in the Women's Health Initiative Observational Study. Chan KH et al. 2011 Clinical chemistry
21160888 Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions. Hishida A et al. 2010 World journal of gastrointestinal oncology
21178102 Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analyses. Persson C et al. 2011 American journal of epidemiology
21291465 The association of genetic polymorphisms with cerebral palsy: a meta-analysis. Wu D et al. 2011 Developmental medicine and child neurology
21297263 Genetic association of sequence variants near AGER/NOTCH4 and dementia. Bennet AM et al. 2011 Journal of Alzheimer's disease
21315679 Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population. Li Y et al. 2011 Cancer epidemiology
21320344 Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population. Joubert BR et al. 2011 BMC medical genetics
21333900 The role of genetics in IBS. Saito YA et al. 2011 Gastroenterology clinics of North America
21357384 Polymorphisms in the TNF-α and IL10 gene promoters and risk of arsenic-induced skin lesions and other nondermatological health effects. Banerjee N et al. 2011 Toxicological sciences
21385363 Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study. Emonts M et al. 2011 BMC medical genetics
21420089 TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis. Rodríguez-Rodríguez L et al. 2011 Atherosclerosis
21437087 Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention. Badawi A et al. 2010 Diabetes, metabolic syndrome and obesity
21447951 Association of inflammation genes with alcohol dependence/abuse: a systematic review and a meta-analysis. Kebir O et al. 2011 European addiction research
21448414 Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease. De Iudicibus S et al. 2011 World journal of gastroenterology
21450487 Tumor necrosis factor-α -863 C/A promoter polymorphism affects the inflammatory response after cardiac surgery. Boehm J et al. 2011 European journal of cardio-thoracic surgery
21514219 Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Zhang B et al. 2011 The Lancet. Oncology
21515823 Genetic predictors for stroke in children with sickle cell anemia. Flanagan JM et al. 2011 Blood
21523452 Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer. Madeleine MM et al. 2011 Breast cancer research and treatment
21533074 GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma. Smedby KE et al. 2011 PLoS genetics
21606320 Genetic associations with sporadic neuroendocrine tumor risk. Ter-Minassian M et al. 2011 Carcinogenesis
21609779 Association of TNF-α and IL-10 polymorphisms with tuberculosis in Tunisian populations. Ben-Selma W et al. 2011 Microbes and infection
21621860 Association of IL1A, IL1B, ILRN, IL6, IL10 and TNF-α polymorphisms with risk and clinical course of multiple sclerosis in a Polish population. Mirowska-Guzel D et al. 2011 Journal of neuroimmunology
21658295 Recent advances in the immunogenetics of idiopathic inflammatory myopathy. Chinoy H et al. 2011 Arthritis research & therapy
21659962 Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates. Ryckman KK et al. 2011 Pediatric research
21670964 Association between TNF-α polymorphisms and cervical cancer risk: a meta-analysis. Liu L et al. 2012 Molecular biology reports
21686124 Design and validity of a clinic-based case-control study on the molecular epidemiology of lymphoma. Cerhan JR et al. 2011 International journal of molecular epidemiology and genetics
21708280 Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis. Srivastava K et al. 2011 Mutation research
21735105 TNF-308 gene polymorphism and tuberculosis susceptibility: a meta-analysis involving 18 studies. Wang Q et al. 2012 Molecular biology reports
21738081 PharmGKB summary: carbamazepine pathway. Thorn CF et al. 2011 Pharmacogenetics and genomics
21756351 Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes. Arora P et al. 2011 BMC medical genetics
21760883 Genetic determinants of UV-susceptibility in non-melanoma skin cancer. Welsh MM et al. 2011 PloS one
21767392 Association of acid phosphatase locus 1*C allele with the risk of cardiovascular events in rheumatoid arthritis patients. Teruel M et al. 2011 Arthritis research & therapy
21773006 Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach. Curti ML et al. 2011 Journal of obesity
21790707 Tumour necrosis factor gene polymorphism and disease prevalence. Qidwai T et al. 2011 Scandinavian journal of immunology
21818296 The TNF-alpha-238 polymorphism and cancer risk: a meta-analysis. Zhou P et al. 2011 PloS one
21846573 Association between genetic risk score and periodontitis onset and progression: a pilot study. Ricci M et al. 2011 Archives of oral biology
21857382 Candidate genes and risk for CP: a population-based study. Wu YW et al. 2011 Pediatric research
21865054 Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy. Napolioni V et al. 2011 Cytokine
21867552 Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites. Diakite M et al. 2011 Malaria journal
21880580 Interaction between functional polymorphic variants in cytokine genes, established risk factors and susceptibility to basal cell carcinoma of skin. Rizzato C et al. 2011 Carcinogenesis
21894447 Are centenarians genetically predisposed to lower disease risk? Ruiz JR et al. 2012 Age (Dordrecht, Netherlands)
21919968 Validation of genetic variants associated with early acute rejection in kidney allograft transplantation. Oetting WS et al. 2012 Clinical transplantation
21926355 A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. Vanasse GJ et al. 2011 Blood
21929748 Genetic polymorphisms linked to susceptibility to malaria. Driss A et al. 2011 Malaria journal
21955043 Validation of single nucleotide polymorphisms associated with acute rejection in kidney transplant recipients using a large multi-center cohort. Oetting WS et al. 2011 Transplant international
21960125 Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates. Ryckman KK et al. 2012 Journal of perinatology
21967963 TNF-α -308 G>A polymorphism and weight gain in patients with schizophrenia under long-term clozapine, risperidone or olanzapine treatment. Huang HH et al. 2011 Neuroscience letters
21980439 A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis. Nakaoka H et al. 2011 PloS one
21985478 TNFA-863 polymorphism is associated with a reduced risk of chronic obstructive pulmonary disease: a replication study. Córdoba-Lanús E et al. 2011 BMC medical genetics
21995493 TNFRSF1B +676 T>G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy. Guan X et al. 2011 BMC cancer
22001640 Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis. Schürks M et al. 2011 Cephalalgia
22024213 A novel gene-environment interaction involved in endometriosis. McCarty CA et al. 2012 International journal of gynaecology and obstetrics
22031281 Preferential transmission of genetic risk variants of candidate loci at 6p21 from asymptomatic grandparents to mothers of children with neonatal lupus. Saxena A et al. 2012 Arthritis and rheumatism
22059093 Risk Factors of Non-Hodgkin Lymphoma. Zhang Y et al. 2011 Expert opinion on medical diagnostics
22070425 Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype. Gueuvoghlanian-Silva BY et al. 2012 American journal of reproductive immunology (New York, N.Y.
22094953 Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients. Sam WJ et al. 2011 Transplantation
22129793 TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis. Daïen CI et al. 2012 Joint bone spine
22140472 Differential combination of cytokine and interferon- γ +874 T/A polymorphisms determines disease severity in pulmonary tuberculosis. Ansari A et al. 2011 PloS one
22172537 A pilot study of host genetic variants associated with influenza-associated deaths among children and young adults. Ferdinands JM et al. 2011 Emerging infectious diseases
22176972 Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis. Zhang J et al. 2011 Respiratory research
22180854 Polymorphisms in Th1/Th2 cytokine genes, hormone replacement therapy, and risk of non-Hodgkin lymphoma. Zhu G et al. 2011 Frontiers in oncology
22190997 Characterization of Single-Nucleotide Polymorphisms in the Tumor Necrosis Factor α Promoter Region and in Lymphotoxin α in Squamous Intraepithelial Lesions, Precursors of Cervical Cancer. Nieves-Ramirez ME et al. 2011 Translational oncology
22294627 Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples. Bolstad AI et al. 2012 Annals of the rheumatic diseases
22295056 Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. Christie JD et al. 2012 PloS one
22347417 Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia. Bol SM et al. 2012 PloS one
22355322 Gene-gene and gene-environmental interactions of childhood asthma: a multifactor dimension reduction approach. Su MW et al. 2012 PloS one
22363536 DRB1*03:01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands. de la Concha EG et al. 2012 PloS one
22372709 Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome. Babu BM et al. 2012 Genetic testing and molecular biomarkers
22376040 Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma. Choi WA et al. 2012 The Journal of asthma
22473907 P-selectin genotype is associated with the development of cancer cachexia. Tan BH et al. 2012 EMBO molecular medicine
22475653 Genetic predictors of fatigue in prostate cancer patients treated with androgen deprivation therapy: preliminary findings. Jim HS et al. 2012 Brain, behavior, and immunity
22487520 TNF-alpha gene (TNFA) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitis. Bishehsari F et al. 2012 Pancreatology
22513132 Interaction between smoking and functional polymorphism in the TGFB1 gene is associated with ischaemic heart disease and myocardial infarction in patients with rheumatoid arthritis: a cross-sectional study. Chen Y et al. 2012 Arthritis research & therapy
22546513 Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer. Lavender NA et al. 2012 BMC medical genomics
22554453 Tumor necrosis factor gene variation predicts hippocampus volume in healthy individuals. Baune BT et al. 2012 Biological psychiatry
22568453 Association of CASP3 polymorphism with hematologic toxicity in patients with advanced non-small-cell lung carcinoma treated with platinum-based chemotherapy. Gu S et al. 2012 Cancer science
22568934 Variation in the IL1B, TNF and IL6 genes and individual susceptibility to prosthetic joint infection. Stahelova A et al. 2012 BMC immunology
22579472 The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women. Oishi Y et al. 2012 Gene
22649007 Genetic polymorphisms in IL10RA and TNF modify the association between blood transfusion and risk of non-Hodgkin lymphoma. Bi X et al. 2012 American journal of hematology
22649680 Association of cytokine gene alleles with the inflammation of human periodontal tissue. Safonova AV et al. 2011 Acta naturae
22666399 Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study. Zhang Y et al. 2012 PloS one
22684480 Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα. Swan C et al. 2013 Gut
22701696 Genetic polymorphisms influence the ovarian response to rFSH stimulation in patients undergoing in vitro fertilization programs with ICSI. Boudjenah R et al. 2012 PloS one
22711844 SNPs in the TNF-α gene promoter associated with Behcet's disease in Moroccan patients. Radouane A et al. 2012 Rheumatology (Oxford, England)
22749237 Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients. Watanabe E et al. 2012 Cytokine
22754196 Cytokine gene polymorphism in idiopathic nephrotic syndrome children. Jafar T et al. 2011 Indian journal of clinical biochemistry
22760475 Association between tumor necrosis factor-α (TNF-α) promoter -308 G/A and response to TNF-α blockers in rheumatoid arthritis: a meta-analysis. Zeng Z et al. 2013 Modern rheumatology
22769019 Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population. Zhao N et al. 2012 Journal of neuroinflammation
22788685 Polymorphisms of pro-inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a Colombian population. Amaya MP et al. 2013 International endodontic journal
22844404 Evidence of associations between cytokine genes and subjective reports of sleep disturbance in oncology patients and their family caregivers. Miaskowski C et al. 2012 PloS one
22873651 Interaction between cytokine gene polymorphisms and the effect of physical exercise on clinical and inflammatory parameters in older women: study protocol for a randomized controlled trial. Pereira DS et al. 2012 Trials
22879966 Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study. Verschuren JJ et al. 2012 PloS one
22897480 Investigation of selected cytokine genes suggests that IL2RA and the TNF/LTA locus are risk factors for severe alopecia areata. Redler S et al. 2012 The British journal of dermatology
22899923 Genetic Influences on Physiological and Subjective Responses to an Aerobic Exercise Session among Sedentary Adults. Karoly HC et al. 2012 Journal of cancer epidemiology
22910888 Role of adipokines in atherosclerosis: interferences with cardiovascular complications in rheumatic diseases. Scotece M et al. 2012 Mediators of inflammation
22925444 Genetic and immunological markers predict titanium implant failure: a retrospective study. Jacobi-Gresser E et al. 2013 International journal of oral and maxillofacial surgery
22927710 Genetic markers of cardiovascular disease in rheumatoid arthritis. Rodríguez-Rodríguez L et al. 2012 Mediators of inflammation
22947458 Malaria resistance genes are associated with the levels of IgG subclasses directed against Plasmodium falciparum blood-stage antigens in Burkina Faso. Afridi S et al. 2012 Malaria journal
22957039 Candidate polymorphisms and severe malaria in a Malian population. Toure O et al. 2012 PloS one
22960943 Influence of polymorphisms and TNF and IL1β serum concentration on the infliximab response in Crohn's disease and ulcerative colitis. Lacruz-Guzmán D et al. 2013 European journal of clinical pharmacology
22969921 TNF-α -863 polymorphisms and the risk of hepatocellular carcinoma. Yang Y et al. 2012 Experimental and therapeutic medicine
22992668 Pharmacogenomics knowledge for personalized medicine. Whirl-Carrillo M et al. 2012 Clinical pharmacology and therapeutics
23011034 Effect of the polymorphisms of tumor necrosis factor-α gene on the susceptibility to primary biliary cirrhosis: a meta-analysis. Qin B et al. 2012 European journal of gastroenterology & hepatology
23024462 Atherosclerosis and rheumatoid arthritis: more than a simple association. Cavagna L et al. 2012 Mediators of inflammation
23029405 Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality. Song Z et al. 2012 PloS one
23029430 Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma. García-González MA et al. 2012 PloS one
23049851 Potential of ayurgenomics approach in complex trait research: leads from a pilot study on rheumatoid arthritis. Juyal RC et al. 2012 PloS one
23050663 Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke. Cui G et al. 2012 Journal of neuroinflammation
23053960 Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis. Lee YH et al. 2012 Molecular biology reports
23057546 TNF-α -857 and -1031 polymorphisms predict good therapeutic response to TNF-α blockers in Chinese Han patients with ankylosing spondylitis. Tong Q et al. 2012 Pharmacogenomics
23057767 Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China. Castro FA et al. 2012 BMC cancer
23072573 Multiplex allele-specific amplification from whole blood for detecting multiple polymorphisms simultaneously. Zhu J et al. 2013 Genetic testing and molecular biomarkers
23073467 Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients. Sam WJ et al. 2012 Transplantation
23077565 Analysis of the interferon gamma (rs2430561, +874T/A) functional gene variant in relation to the presence of cardiovascular events in rheumatoid arthritis. García-Bermúdez M et al. 2012 PloS one
23086128 Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer. de Oliveira JG et al. 2013 Digestive diseases and sciences
23107763 Host genetic risk factors for community-acquired pneumonia. Salnikova LE et al. 2013 Gene
23119005 HLA and celiac disease susceptibility: new genetic factors bring open questions about the HLA influence and gene-dosage effects. Medrano LM et al. 2012 PloS one
23133455 TNF-α Polymorphisms in Juvenile Idiopathic Arthritis: Which Potential Clinical Implications? Scardapane A et al. 2012 International journal of rheumatology
23148654 Pandemic influenza A/H1N1 virus infection and TNF, LTA, IL1B, IL6, IL8, and CCL polymorphisms in Mexican population: a case-control study. Morales-García G et al. 2012 BMC infectious diseases
23157966 Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations. Elhawy E et al. 2012 Human genomics
23159874 Pro-inflammatory cytokine gene polymorphisms and threat for coronary heart disease in a North Indian Agrawal population. Garg PR et al. 2013 Gene
23213275 Association of vascular endothelial growth factor, transforming growth factor beta, and interferon gamma gene polymorphisms with proliferative diabetic retinopathy in patients with type 2 diabetes. Paine SK et al. 2012 Molecular vision
23226040 Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies. O'Rielly DD et al. 2010 Pharmacogenomics and personalized medicine
23241556 Haplotype of single nucleotide polymorphisms in exon 6 of the MZF-1 gene and Alzheimer's disease. Porcellini E et al. 2013 Journal of Alzheimer's disease
23251429 Inflammation and immune-related candidate gene associations with acute lung injury susceptibility and severity: a validation study. O'Mahony DS et al. 2012 PloS one
23251581 Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades. Jiang Y et al. 2012 PloS one
23267696 Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study. Guo Y et al. 2012 BMC medical genomics
23294973 Association of TNF-α polymorphism rs1800629 with multisomatoform disorder in a group of German patients and healthy controls: an explorative study. Harms KC et al. 2013 Cytokine
23316245 The host genetic diversity in malaria infection. de Mendonça VR et al. 2012 Journal of tropical medicine
23357300 Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients. Mishra A et al. 2013 Cytokine
23380141 Association of HLA-DRB1 and TNF genotypes with dengue hemorrhagic fever. Alagarasu K et al. 2013 Human immunology
23391141 Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab. Yri OE et al. 2013 Leukemia & lymphoma
23406059 Inflammatory factors gene polymorphism in recurrent oral ulceration. Sun M et al. 2013 Journal of oral pathology & medicine
23430759 TNF-α, IL6, and IL10 polymorphisms and the effect of physical exercise on inflammatory parameters and physical performance in elderly women. Pereira DS et al. 2013 Age (Dordrecht, Netherlands)
23438931 Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension. Kostis WJ et al. 2013 Hypertension (Dallas, Tex.
23453739 Lack of association between TNFα rs1800629 polymorphism and schizophrenia risk: a meta-analysis. Qin H et al. 2013 Psychiatry research
23459936 Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Divaris K et al. 2013 Human molecular genetics
23527081 A large scale gene-centric association study of lung function in newly-hired female cotton textile workers with endotoxin exposure. Zhang R et al. 2013 PloS one
23530106 Cytokine genetic variations and fatigue among patients with breast cancer. Bower JE et al. 2013 Journal of clinical oncology
23554684 Genetic susceptibility of cervical cancer. Chen X et al. 2011 Journal of biomedical research
23590430 Genetic polymorphisms of tumour necrosis factor alpha (TNF-α) promoter gene and response to TNF-α inhibitors in Spanish patients with inflammatory bowel disease. López-Hernández R et al. 2014 International journal of immunogenetics
23640160 IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations. Hosgood HD 3rd et al. 2013 International journal of hematology
23748461 Association analysis of two candidate polymorphisms in the tumour necrosis factor-α gene with osteoarthritis in a Chinese population. Ji B et al. 2013 International orthopaedics
23766564 Pharmacogenetics of chronic pain and its treatment. Světlík S et al. 2013 Mediators of inflammation
23796916 Tumor necrosis factor alpha promoter polymorphism and severity of acute kidney injury. Susantitaphong P et al. 2013 Nephron. Clinical practice
23880893 Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma. MacIntyre EA et al. 2013 European journal of epidemiology
23895869 TNF-alpha promoter region polymorphisms affect HBV virus clearance in southern Chinese. Xu J et al. 2013 Clinica chimica acta; international journal of clinical chemistry
23906902 Tumor necrosis factor-308 polymorphism increases the embryo implantation rate in women undergoing in vitro fertilization. Vialard F et al. 2013 Human reproduction (Oxford, England)
23919499 Associations between tumor necrosis factor alpha gene -238 G/A and -308 G/A polymorphisms and the risk of pneumoconiosis: update of a meta-analysis. Yin YW et al. 2013 Current medical research and opinion
23946381 Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Ma X et al. 2014 Gut
23975191 TNF-α haplotype association with polycystic ovary syndrome - a South Indian study. Deepika ML et al. 2013 Journal of assisted reproduction and genetics
24008079 Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts. Ghesquières H et al. 2013 Cytokine
24037955 The presence of prostate cancer at biopsy is predicted by a number of genetic variants. Kashyap A et al. 2014 International journal of cancer
24054031 Genetic variation in cytokine-related genes and migraine susceptibility. Stuart S et al. 2013 Twin research and human genetics
24059882 Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians. Boehm J et al. 2014 Renal failure
24065540 MMP-2, TNF-α and NLRP1 polymorphisms in Chinese patients with ankylosing spondylitis and rheumatoid arthritis. Sun R et al. 2013 Molecular biology reports
24069534 Genetics of psoriasis and pharmacogenetics of biological drugs. Prieto-Pérez R et al. 2013 Autoimmune diseases
24072494 Quantitative assessment of the influence of tumor necrosis factor alpha polymorphism with gastritis and gastric cancer risk. Li M et al. 2014 Tumour biology
24114820 Genetic factors affecting susceptibility to alcoholic liver disease in an Indian population. Dutta AK et al. 2013 Annals of hepatology
24142527 Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a meta-analysis. Zhu F et al. 2014 Tumour biology
24151497 Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria. Khaib Dit Naib O et al. 2013 Frontiers in immunology
24192118 Association of TNF-α polymorphism with prediction of response to TNF blockers in spondyloarthritis and inflammatory bowel disease: a meta-analysis. Tong Q et al. 2013 Pharmacogenomics
24252077 Association of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis. Jia Y et al. 2013 Clinical and experimental dermatology
24281113 Inflammatory genetic markers of prostate cancer risk. Tindall EA et al. 2010 Cancers
24465030 GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study. MacIntyre EA et al. 2014 Environmental health perspectives
24497894 A Conceptual Model of Psychoneurological Symptom Cluster Variation in Women with Breast Cancer: Bringing Nursing Research to Personalized Medicine. Starkweather AR et al. 2013 Current pharmacogenomics and personalized medicine
24502445 Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery. Leung G et al. 2014 Lymphatic research and biology
24521996 Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations--an extensive replication of the associations from the candidate gene era. Martino A et al. 2014 Cancer epidemiology, biomarkers & prevention
24557424 Polymorphisms in tumor necrosis factor-α increase susceptibility to intra-abdominal Candida infection in high-risk surgical ICU patients*. Wójtowicz A et al. 2014 Critical care medicine
24597698 Tumour necrosis factor-alpha, interleukin-10, interferon-gamma and vitamin D receptor gene polymorphisms in patients with chronic hepatitis delta. Karatayli SC et al. 2014 Journal of viral hepatitis
24678851 Tumor necrosis factor-α and oral inflammation in patients with Crohn disease. Schulz S et al. 2014 Journal of periodontology
24701578 The role of single nucleotide polymorphisms in predicting prostate cancer risk and therapeutic decision making. Van den Broeck T et al. 2014 BioMed research international
24702779 Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia. Harmon QE et al. 2014 American journal of reproductive immunology (New York, N.Y.
24753491 Polymorphism at the TNF-alpha gene interacts with Mediterranean diet to influence triglyceride metabolism and inflammation status in metabolic syndrome patients: From the CORDIOPREV clinical trial. Gomez-Delgado F et al. 2014 Molecular nutrition & food research
24872120 Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers. Dhruva A et al. 2015 Biological research for nursing
24895604 Antioxidant defense enzyme genes and asthma susceptibility: gender-specific effects and heterogeneity in gene-gene interactions between pathogenetic variants of the disease. Polonikov AV et al. 2014 BioMed research international
24901479 Ethnic background and genetic variation in the evaluation of cancer risk: a systematic review. Jing L et al. 2014 PloS one
24905365 TNF-α gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studies. Ding C et al. 2014 Journal of clinical periodontology
24909419 A 30-years review on pharmacokinetics of antibiotics: is the right time for pharmacogenetics? Baietto L et al. 2014 Current drug metabolism
24936650 Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis. Yang G et al. 2014 PloS one
24944790 Screening for 392 polymorphisms in 141 pharmacogenes. Kim JY et al. 2014 Biomedical reports
24971461 Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort. Bank S et al. 2014 PloS one
25000179 Genetic polymorphisms and sepsis in premature neonates. Esposito S et al. 2014 PloS one
25010932 Association of TNF-α, TNFRSF1A and TNFRSF1B gene polymorphisms with the risk of sporadic breast cancer in northeast Chinese Han women. Xu F et al. 2014 PloS one
25022448 Polymorphisms in cytokine genes IL6, TNF, IL10, IL17A and IFNG influence susceptibility to complicated skin and skin structure infections. Stappers MH et al. 2014 European journal of clinical microbiology & infectious diseases
25054016 Association of <i>NQO1</i> and <i>TNF</i> polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies. Dai D et al. 2014 Biomedical reports
25097799 Developments in Ocular Genetics: 2013 Annual Review. Aboobakar IF et al. 2014 Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
25124382 Methylenetetrahydrofolate reductase C667T polymorphism is associated with increased risk of coronary artery disease in a Chinese population. Chen W et al. 2014 Scandinavian journal of immunology
25127106 Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease. Durães C et al. 2014 PloS one
25175451 The functional VNTR of IGH enhancer HS1.2 associates with human longevity and interacts with TNFA promoter diplotype in a population of Central Italy. Napolioni V et al. 2014 Gene
25214541 A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage. Findlay JM et al. 2015 Annals of oncology
25238536 Association of cytokines in individuals sensitive and insensitive to dust mites in a Brazilian population. Caniatti MC et al. 2014 PloS one
25239251 Gene polymorphisms in patients with pulmonary tuberculosis from Mozambique. Mabunda N et al. 2015 Molecular biology reports
25256363 Association of the tumor necrosis factor -308 A/G promoter polymorphism with Tourette syndrome. Keszler G et al. 2014 International journal of immunogenetics
25263964 Polymorphisms in the TNF-α, TNFR1 gene and risk of rheumatoid arthritis in Chinese Han population. Li F et al. 2014 International journal of immunogenetics
25315199 Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine. Rodriguez-Acevedo AJ et al. 2014 The journal of headache and pain
25359546 Pro- and anti-inflammatory cytokine gene single-nucleotide polymorphisms in inflammatory bowel disease. López-Hernández R et al. 2015 International journal of immunogenetics
25368751 Investigation of -308G&gt;A and -1031T&gt;C polymorphisms in the TNFA promoter region in Polish peptic ulcer patients. Sałagacka A et al. 2014 Gut and liver
25409741 A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia. Huusko JM et al. 2014 BMC medical genetics
25510954 TNFα polymorphism as marker of immunosenescence for rheumatoid arthritis patients. Rodríguez-Carrio J et al. 2015 Experimental gerontology
25544182 Genetic variation in the promoter region of pro-inflammatory cytokine TNF-α in perinatal HIV transmission from Mumbai, India. Ahir S et al. 2015 Cytokine
25545232 Donors with HLA-B*58:01/TNFα − 308A haplotype are unfavorable to haploidentical hematopoietic stem cell transplantation in acute lymphoblastic leukemia. Yang L et al. 2015 Transplant immunology
25559835 Genetic polymorphisms in inflammatory response genes and their associations with breast cancer risk. Wang Z et al. 2014 Croatian medical journal
25589894 High producing tumor necrosis factor alpha gene alleles in protection against severe manifestations of dengue. Sam SS et al. 2015 International journal of medical sciences
25596176 Effects of chronic interpersonal stress exposure on depressive symptoms are moderated by genetic variation at IL6 and IL1β in youth. Tartter M et al. 2015 Brain, behavior, and immunity
25606441 In silico analysis of single nucleotide polymorphism (SNP) in human TNF-α gene. Dabhi B et al. 2014 Meta gene
25614219 TNF-α -308 G/A as a risk marker of cervical cancer progression in the Polish population. Roszak A et al. 2015 Molecular diagnosis & therapy
25636570 Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil. Silva GA et al. 2015 Human immunology
25661739 TNF-308 G/A polymorphism and risk of systemic lupus erythematosus in the Polish population. Piotrowski P et al. 2015 Modern rheumatology
25663919 Effect of three common IL-17 single nucleotide polymorphisms on the risk of developing gastric cancer. Gao YW et al. 2015 Oncology letters
25694817 Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study. Chen Z et al. 2015 Journal of thoracic disease
25713336 Associations of non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci. Wang SS et al. 2015 American journal of epidemiology
25721048 Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. Yucesoy B et al. 2016 Journal of immunotoxicology
25807366 Urinary proteins, vitamin D and genetic polymorphisms as risk factors for febrile urinary tract infection and relation with bacteremia: a case control study. van der Starre WE et al. 2015 PloS one
25809685 Common Variants and Haplotypes in the TF, TNF-α, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population. Gichohi-Wainaina WN et al. 2015 The Journal of nutrition
25822988 The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women. Mrizak I et al. 2015 The British journal of nutrition
25839939 Genetic association of IL-6, TNF-α and SDF-1 polymorphisms with serum cytokine levels in diabetic foot ulcer. Dhamodharan U et al. 2015 Gene
25849827 Evaluation of genetic polymorphisms in clusterin and tumor necrosis factor-alpha genes in South Indian individuals with pseudoexfoliation syndrome. Dubey SK et al. 2015 Current eye research
25928231 Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis. Wang S et al. 2015 BMC medical genetics
25962811 Non-Hodgkin Lymphoma, Body Mass Index, and Cytokine Polymorphisms: A Pooled Analysis from the InterLymph Consortium. Kane E et al. 2015 Cancer epidemiology, biomarkers & prevention
25965561 Linkage disequilibrium with HLA-DRB1-DQB1 haplotypes explains the association of TNF-308G&gt;A variant with type 1 diabetes in a Brazilian cohort. Patente TA et al. 2015 Gene
25980667 Pharmacogenetics of treatment response in psoriatic arthritis. Jani M et al. 2015 Current rheumatology reports
26088449 Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer. de Oliveira JG et al. 2015 Tumour biology
26088606 Tumour necrosis factor allele variants and their association with the occurrence and severity of malaria in African children: a longitudinal study. Gichohi-Wainaina WN et al. 2015 Malaria journal
26112140 The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients. Korobeinikova E et al. 2015 BMC genetics
26117649 Prediction of feature genes in trauma patients with the TNF rs1800629 A allele using support vector machine. Chen G et al. 2015 Computers in biology and medicine
26170653 Identification of genetic variants in the TNF promoter associated with COPD secondary to tobacco smoking and its severity. Reséndiz-Hernández JM et al. 2015 International journal of chronic obstructive pulmonary disease
26224639 The association between tumor necrosis factor-α-308 G/A polymorphism and risk for vitiligo: a meta-analysis. Wu D et al. 2015 International journal of dermatology
26244882 Association between TNF-α (-308 A/G, -238 A/G, -857 C/T) polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis. Song GG et al. 2015 Pharmacogenomics
26248682 Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing. Mekli K et al. 2016 Aging clinical and experimental research
26394672 Association of Single-Nucleotide Polymorphisms in IL28B, but Not TNF-α, With Severity of Disease Caused by Andes Virus. Angulo J et al. 2015 Clinical infectious diseases
26396182 Genetic variant of Interleukin-18 gene is associated with the Frailty Index in the English Longitudinal Study of Ageing. Mekli K et al. 2015 Age and ageing
26408612 Association of TNF-α gene polymorphisms with 
the risk of rheumatoid arthritis in 
Han Chinese population from Hunan. Li F et al. 2015 Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
26572151 Polymorphisms of tumor necrosis factor alpha in Middle Eastern population with colorectal cancer. Hamadien MA et al. 2016 Tumour biology
26601827 The IL-1B Genetic Polymorphism Is Associated with Aspirin-Induced PepticUlcers in a Korean Ethnic Group. Cho JH et al. 2016 Gut and liver
26612435 TGFβ3 (TGFB3) polymorphism is associated with male infertility. Droździk M et al. 2015 Scientific reports
26613086 Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis. Prieto-Pérez R et al. 2015 Journal of immunology research
26627480 Genetic predisposition to acute kidney injury--a systematic review. Vilander LM et al. 2015 BMC nephrology
26643661 Preliminary evaluation of exome sequencing to identify genetic markers of susceptibility to tuberculosis disease. Duncan C et al. 2015 BMC research notes
26648684 Update on genetics and diabetic retinopathy. Hampton BM et al. 2015 Clinical ophthalmology (Auckland, N.Z.)
26657940 TNF, IL6, and IL1B Polymorphisms Are Associated with Severe Influenza A (H1N1) Virus Infection in the Mexican Population. García-Ramírez RA et al. 2015 PloS one
26658659 Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians. Barsova RM et al. 2015 PloS one
26670709 Are Immune Modulating Single Nucleotide Polymorphisms Associated with Necrotizing Enterocolitis? Franklin AL et al. 2015 Scientific reports
26672513 Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea. Shin SP et al. 2015 World journal of gastroenterology
26690118 An Updated Review on the Genetics of Primary Open Angle Glaucoma. Abu-Amero K et al. 2015 International journal of molecular sciences
26750615 Tumor necrosis factor-α G-308A (rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies. Wei XM et al. 2016 Scientific reports
26751459 Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study. Hernández-Díaz Y et al. 2016 International journal of environmental research and public health
26761187 Tumor necrosis factor (TNF)-α -308G/A (rs1800629) polymorphism distribution in North India and its association with pemphigus: Case-control study and meta-analysis. Dar SA et al. 2016 Autoimmunity
26789123 A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation. Benson KA et al. 2016 PloS one
26793196 Gene Association with Leprosy: A Review of Published Data. Mazini PS et al. 2015 Frontiers in immunology
26798436 Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike. Figura N et al. 2016 World journal of gastrointestinal oncology
26821796 Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy. Kaidonis G et al. 2016 Diabetes & vascular disease research
26829382 The -308 bp TNF gene polymorphism influences tumor necrosis factor expression in leprosy patients in Bahia State, Brazil. Oliveira JM et al. 2016 Infection, genetics and evolution
26830988 Study of Clinical and Genetic Risk Factors for Aspirin-induced Gastric Mucosal Injury. Wu Y et al. 2016 Chinese medical journal
26837816 Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis. Li HH et al. 2016 Reproductive biology and endocrinology
26840977 Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population. Milano M et al. 2016 PloS one
26846412 Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study. Ramos BR et al. 2016 BMC pregnancy and childbirth
26857559 A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers. León-Cachón RBR et al. 2016 BMC cancer
26861312 Association between Genetic Polymorphisms and Response to Anti-TNFs in Patients with Inflammatory Bowel Disease. Prieto-Pérez R et al. 2016 International journal of molecular sciences
26876219 Relationship of bovine TNF-α gene polymorphisms with the risk of bovine tuberculosis in Holstein cattle. Cheng Y et al. 2016 The Journal of veterinary medical science
26890368 TNF-α and IL-10 polymorphisms increase the risk to hepatocellular carcinoma in HCV infected individuals. Aroucha DC et al. 2016 Journal of medical virology
26894582 Association of Vitamin D Receptor Polymorphism with Susceptibility to Symptomatic Pertussis. Han WG et al. 2016 PloS one
26914399 TNF-α and IL10 gene polymorphisms in women with postmenopausal osteoporosis. Kotrych D et al. 2016 European journal of obstetrics, gynecology, and reproductive biology
26999109 Expression and Sequence Variants of Inflammatory Genes; Effects on Plasma Inflammation Biomarkers Following a 6-Week Supplementation with Fish Oil. Cormier H et al. 2016 International journal of molecular sciences
27026833 Replication Study of Polymorphisms Associated With Brain Arteriovenous Malformation in a Population From South of Brazil. Franciscatto AC et al. 2016 Cureus
27054030 The dual roles of cytokines in Alzheimer's disease: update on interleukins, TNF-α, TGF-β and IFN-γ. Zheng C et al. 2016 Translational neurodegeneration
27073425 Candidate gene polymorphisms and risk of psoriasis: A pilot study. Villarreal-Martínez A et al. 2016 Experimental and therapeutic medicine
27105877 Association of Genetic Polymorphisms in TNF and MIF Gene with the Risk of Primary Dysmenorrhea. Dogru HY et al. 2016 Biochemical genetics
27118427 Association study of inflammatory genes with rheumatic heart disease in North Indian population: A multi-analytical approach. Gupta U et al. 2016 Immunology letters
27131251 Influence of TNF-α-308 G/A gene polymorphism on temporomandibular disorder. Furquim BD et al. 2016 American journal of orthodontics and dentofacial orthopedics
27159547 Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α. Nascimento H et al. 2016 Childhood obesity (Print)
27177030 Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia. Srinivas L et al. 2016 Journal of neuroinflammation
27187381 Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-α (TNF-α) in Major Depressive Disorder: A Systematic Review. Ma K et al. 2016 International journal of molecular sciences
27217270 Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis. Zhang JP et al. 2016 Schizophrenia bulletin
27220278 Risk allelic load in Th2 and Th3 cytokines genes as biomarker of susceptibility to HPV-16 positive cervical cancer: a case control study. Torres-Poveda K et al. 2016 BMC cancer
27233255 Association of gene polymorphisms of FV, FII, MTHFR, SERPINE1, CTLA4, IL10, and TNFalpha with pre-eclampsia in Chinese women. Zhou L et al. 2016 Inflammation research
27247849 Genetic variation and cognitive dysfunction in opioid-treated patients with cancer. Kurita GP et al. 2016 Brain and behavior
27264274 The G allele in IL-10-1082 G/A may have a role in lowering the susceptibility to panic disorder in female patients. Kim HJ et al. 2016 Acta neuropsychiatrica
27277665 Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population. Zholdybayeva EV et al. 2016 Human genomics
27294501 Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing. Baumert P et al. 2016 European journal of applied physiology
27332551 Associations between Common Variants in Iron-Related Genes with Haematological Traits in Populations of African Ancestry. Gichohi-Wainaina WN et al. 2016 PloS one
27366637 Genetic markers of inflammation may not contribute to metabolic traits in Mexican children. Vashi N et al. 2016 PeerJ
27386381 Association of inflammatory gene polymorphisms with mechanical heart valve reoperation. Lee KE et al. 2016 SpringerPlus
27401061 Associations of TNF-α and IL-6 polymorphisms with osteoporosis through joint effects and interactions with LEPR gene in Taiwan: Taichung Community Health Study for Elders (TCHS-E). Lin CC et al. 2016 Molecular biology reports
27411394 Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus. Yiallouros PK et al. 2016 Italian journal of pediatrics
27415837 Cervical Cancer Genetic Susceptibility: A Systematic Review and Meta-Analyses of Recent Evidence. Martínez-Nava GA et al. 2016 PloS one
27417569 Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases. Bek S et al. 2016 Alimentary pharmacology & therapeutics
27437086 Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences. Eom SY et al. 2016 Toxicological research
27455075 Pro-inflammatory cytokine single nucleotide polymorphisms in Kawasaki disease. Assari R et al. 2018 International journal of rheumatic diseases
27456841 Association of the tumor necrosis factor-alpha promoter polymorphism with change in triacylglycerol response to sequential meals. Jackson KG et al. 2016 Nutrition journal
27462201 From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research. Pagliaroli L et al. 2016 Frontiers in neuroscience
27468700 Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis. Wu L et al. 2016 Scientific reports
27477483 TNFA gene variants related to the inflammatory status and its association with cellular aging: From the CORDIOPREV study. Rangel-Zúñiga OA et al. 2016 Experimental gerontology
27515689 Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer. Kerns SL et al. 2016 EBioMedicine
27520094 Reticulocyte count is the most important predictor of acute cerebral ischemia and high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia. Belisário AR et al. 2016 Annals of hematology
27528546 Tumour necrosis factor-alpha (-308G/A) promoter polymorphism is associated with ulcerative colitis in Brazilian patients. Tavares M et al. 2016 International journal of immunogenetics
27555379 Genetic Contributions of Inflammation to Depression. Barnes J et al. 2017 Neuropsychopharmacology
27555891 Pharmacogenetic studies update in type 2 diabetes mellitus. Singh S et al. 2016 World journal of diabetes
27589735 A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification. Ponasenko AV et al. 2016 International journal of molecular sciences
27592234 Variants in LTA, TNF, IL1B and IL10 genes associated with the clinical course of sepsis. Montoya-Ruiz C et al. 2016 Immunologic research
27597177 TNF-α -308 G &gt; A (rs1800629) Polymorphism is Associated with Celiac Disease: A Meta-analysis of 11 Case-Control Studies. Khan S et al. 2016 Scientific reports
27598147 Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention. Fitó M et al. 2016 International journal of molecular sciences
27616475 Gene variants as risk factors for gastroschisis. Padula AM et al. 2016 American journal of medical genetics. Part A
27624002 Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children. Karaca S et al. 2016 Scientific reports
27640071 Gene-environment interactions linking air pollution and inflammation in Parkinson's disease. Lee PC et al. 2016 Environmental research
27670835 Systematic meta-analyses and field synopsis of genetic and epigenetic studies in paediatric inflammatory bowel disease. Li X et al. 2016 Scientific reports
27689253 Role of Cytokine Gene Score in Risk Prediction of Premature Coronary Artery Disease. Omer W et al. 2016 Genetic testing and molecular biomarkers
27701469 Impact of TNF-α (rs1800629) and IL-6 (rs1800795) Polymorphisms on Cognitive Impairment in Asian Breast Cancer Patients. Chae JW et al. 2016 PloS one
27713886 The role of genetics and antibodies in sepsis. Giamarellos-Bourboulis EJ et al. 2016 Annals of translational medicine
27730450 Candidate gene studies of diabetic retinopathy in human. Priščáková P et al. 2016 Molecular biology reports
27809686 Association of promoter polymorphism -857C/T (rs1799724) in tumor necrosis factor gene with intracerebral hemorrhage in Korean males. Park HJ et al. 2017 Neurological research
27821804 Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis. Luo M et al. 2016 Oncotarget
27861595 TLR4/CD14 Variants-Related Serologic and Immunologic Dys-Regulations Predict Severe Sepsis in Febrile De-Compensated Cirrhotic Patients. Fan WC et al. 2016 PloS one
27895843 Severe anemia in Malawian children. Calis JC et al. 2016 Malawi medical journal
27997918 Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients. Laytragoon-Lewin N et al. 2017 Oncology
28117391 Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib. Cebrián A et al. 2017 Scientific reports
28152281 Glutathione-S-transferase P1 may predispose children to a decline in pulmonary function after stem cell transplant. Stark J et al. 2017 Pediatric pulmonology
28160694 Genetic and serum biomarker evidence for a relationship between TNFα and PTSD in Vietnam war combat veterans. Bruenig D et al. 2017 Comprehensive psychiatry
28243990 Associations between single-nucleotide polymorphisms and inflammatory bowel disease-associated colorectal cancers in inflammatory bowel disease patients: a meta-analysis. Li H et al. 2017 Clinical & translational oncology
28300283 Immunology and genetics of tumour necrosis factor in allergic contact dermatitis. Dittmar D et al. 2017 Contact dermatitis
28314127 Suicide attempt in mental disorders (MeDi): Association with 5-HTT, IL-10 and TNF-alpha polymorphisms. de Medeiros Alves V et al. 2017 Journal of psychiatric research
28316053 The use of rapid and cost-effective blood-based biomarkers in combination with tumour TNM stage for individual head and neck cancer patient treatment selection. Laytragoon Lewin N et al. 2017 Medical oncology (Northwood, London, England)
28358286 Association of cytokines polymorphisms with chronic peridontitis and rheumatoid arthritis in a Mexican population. Domínguez-Pérez RA et al. 2017 Acta odontologica Scandinavica
28361429 Possible Role of Polymorphisms in TNFA, NFKB1, and CASP8 Gene Promoter Areas in the Development of Chronic Lymphocytic Leukemia. Ovsepyan VA et al. 2017 Bulletin of experimental biology and medicine
28374494 Immunogenetic profiling of 23 SNPs of cytokine and chemokine receptor genes through a minisequencing technique: Design, development and validation. Valverde-Villegas JM et al. 2017 International journal of immunogenetics
28384885 Profile of Tumour Necrosis Factor Alpha -308 G/A Gene Polymorphism in Psoriatic Patients in Karnataka, India. Rajesh D et al. 2017 Journal of clinical and diagnostic research
28388928 SNPPhenA: a corpus for extracting ranked associations of single-nucleotide polymorphisms and phenotypes from literature. Bokharaeian B et al. 2017 Journal of biomedical semantics
28395167 The association of Enamelin, Lactoferrin, and Tumour necrosis factor alpha gene polymorphisms with high caries susceptibility in Chinese children under 4 years old. Wang M et al. 2017 Archives of oral biology
28464990 EPHX1 Y113H polymorphism is associated with increased risk of chronic obstructive pulmonary disease in Kazakhstan population. Akparova A et al. 2017 Mutation research. Genetic toxicology and environmental mutagenesis
28495402 Associations of tumor necrosis factor-α-308 polymorphism with dengue infection: A systematic review and meta-analysis. Pabalan N et al. 2017 Acta tropica
28501927 Cytokine gene polymorphism associations with congenital cytomegalovirus infection and sensorineural hearing loss. Kasztelewicz B et al. 2017 European journal of clinical microbiology & infectious diseases
28527290 Association of polymorphic variants of PTPN22, TNF and VDR genes in children with lupus nephritis: A study in Colombian family triads. Garavito G et al. 2017 Biomedica
28575042 TNF-α -308 A allele is associated with an increased risk of distant metastasis in rectal cancer patients from Southwestern China. Li Z et al. 2017 PloS one
28620227 Gene-physical activity interactions in lower extremity performance: inflammatory genes CRP, TNF-α, and LTA in community-dwelling elders. Liu CS et al. 2017 Scientific reports
28620993 The Role of TLR4, TNF-α and IL-1β in Type 2 Diabetes Mellitus Development within a North Indian Population. Doody NE et al. 2017 Annals of human genetics
28633686 Polymorphisms of the TNF-α gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in São Paulo, Brazil. Oki E et al. 2017 The British journal of nutrition
28652652 Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update. Sharma A et al. 2017 World journal of gastroenterology
28675059 Immunogenetic predisposing factors for mesial temporal lobe epilepsy with hippocampal sclerosis. Leal B et al. 2018 The International journal of neuroscience
28695434 The single-nucleotide polymorphism (SNP) of tumor necrosis factor α -308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population. Abdel Galil SM et al. 2017 Clinical rheumatology
28702675 TNF-α Genetic Predisposition and Higher Expression of Inflammatory Pathway Components in Keratoconus. Arbab M et al. 2017 Investigative ophthalmology & visual science
28703132 Association of a functional TNF variant with Plasmodium falciparum parasitaemia in a congolese population. Nguyen TN et al. 2017 Genes and immunity
28716390 Impact of cytokine genetic polymorphisms on the risk of renal parenchymal infection in children. Hussein A et al. 2017 Journal of pediatric urology
28740106 Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes. Song Y et al. 2017 Scientific reports
28765340 Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium. Campa D et al. 2017 Cancer epidemiology, biomarkers & prevention
28785150 Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease. Netz U et al. 2017 World journal of gastroenterology
28827564 The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction. Bielecka-Dabrowa A et al. 2017 Scientific reports
28844157 Validation of genetic predictors of late radiation-induced morbidity in prostate cancer patients. Schack LMH et al. 2017 Acta oncologica (Stockholm, Sweden)
28881857 Genetic association between <i>TNF-α</i> promoter polymorphism and susceptibility to squamous cell carcinoma, basal cell carcinoma, and melanoma: A meta-analysis. Liu N et al. 2017 Oncotarget
28935761 Impact of <i>TNF</i> -308 G&gt;A (rs1800629) gene polymorphism in modulation of leprosy risk: a reappraise meta-analysis of 14 case-control studies. Areeshi MY et al. 2017 Bioscience reports
28963676 Genetic variants of tumor necrosis factor-α -308G/A (rs1800629) but not Toll-interacting proteins or vitamin D receptor genes enhances susceptibility and severity of malaria infection. Ojurongbe O et al. 2018 Immunogenetics
28980933 Predictive role of cytokines IL-10, IL-12 and TNF-α gene polymorphisms for the development of osteonecrosis of the femoral head in the Chinese Han population. Yuan L et al. 2017 Cellular and molecular biology (Noisy-le-Grand, France)
28993561 A Missense Variant rs4645843 in TNF-α Gene Is a Risk Factor of Polycystic Ovary Syndrome in the Uygur Population. Li S et al. 2017 The Tohoku journal of experimental medicine
29041886 [Polymorphisms in Genes of Cytokines and Matrix Metalloproteinases Associated With Ischemic Heart Disease in Patients With Type 2 Diabetes]. Klimontov VV et al. 2017 Kardiologiia
29042282 Increased levels of circulating (TNF-α) is associated with (-308G/A) promoter polymorphism of TNF-α gene in Diabetic Nephropathy. Umapathy D et al. 2018 International journal of biological macromolecules
29054398 Association of TNF-Alpha gene polymorphisms and susceptibility to hepatitis B virus infection in Egyptians. Talaat RM et al. 2017 Human immunology
29056124 Association of ADIPOQ C-11377G (rs266729), TNF-α αG-308A(rs1800629) and TNF-α αG-238A(rs361525) Single Nucleotide Polymorphisms with Type 2 Diabetes Mellitus in Pakistani Population. Nadeem A et al. 2017 Journal of the College of Physicians and Surgeons--Pakistan
29130827 Association of Single-Nucleotide Polymorphisms in Immune-Related Genes with Development of Dengue Hemorrhagic Fever in a Mexican Population. Vargas-Castillo AB et al. 2018 Viral immunology
29136357 Association of cytokine gene polymorphisms with bronchopulmonary dysplasia in Han Chinese newborns. Chen H et al. 2018 Pediatric pulmonology
29164277 High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil. Pereira ACTDC et al. 2018 Immunogenetics
29172674 Single nucleotide polymorphisms in TNF are associated with susceptibility to aspirin-exacerbated respiratory disease but not to cytokine levels: a study in Mexican mestizo population. Pavón-Romero GF et al. 2017 Biomarkers in medicine
29181663 Gene TNF Polymorphism -308G&gt;A (rs1800629) and Its Relationship with the Efficiency of Ursodeoxycholic Acid Therapy in Patients with Nonalcoholic Stetohepatitis. Kurbatova IV et al. 2017 Bulletin of experimental biology and medicine
29193749 Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years. Borobia AM et al. 2018 Clinical and translational science
29218062 Preliminary Study Regarding the Association between Tumor Necrosis Factor Alpha Gene Polymorphisms and Childhood Idiopathic Nephrotic Syndrome in Romanian Pediatric Patients. Tieranu I et al. 2017 Maedica
29230494 Association of polymorphisms in TNF and GRN genes with ankylosing spondylitis in a Chinese Han population. Hu N et al. 2018 Rheumatology international
29247331 Polymorphisms in inflammation-related genes and the risk of primary varicose veins in ethnic Russians. Shadrina A et al. 2018 Immunologic research
29256014 Genetic variation in TNFα, PPARγ, and IRS-1 genes, and their association with breast-cancer survival in the HEAL cohort. Duggan C et al. 2018 Breast cancer research and treatment
29298134 The Synergistic Effect of TNFA and IL10 Promoter Polymorphisms on Genetic Predisposition to Systemic Lupus Erythematosus. Manolova I et al. 2018 Genetic testing and molecular biomarkers
29340067 The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk. Zhang Y et al. 2017 Oncotarget
29388847 The role of TNF alpha polymorphism and expression in susceptibility to nasal polyposis. Zhang G et al. 2018 Immunological investigations
29404828 Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population. Cadena-Sandoval D et al. 2018 Molecular biology reports
29406912 TNF-α -308 G/A and -238 G/A promoter polymorphisms and sporadic Parkinson's disease in an Italian cohort. Agliardi C et al. 2018 Journal of the neurological sciences
29426041 Genetic Polymorphisms in Cytokine Genes in Colombian Patients with Ocular Toxoplasmosis. Naranjo-Galvis CA et al. 2018 Infection and immunity
29430075 Polymorphisms in the <i>SP110</i> and <i>TNF-α</i> Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population. Zhou Y et al. 2017 Disease markers
29440561 Association of <i>TNF-α</i> promoter polymorphism and Graves' disease: an updated systematic review and meta-analysis. Tu Y et al. 2018 Bioscience reports
29449347 Association of tumor necrosis factor-α (TNF-α) gene promoter polymorphisms with aggressive and chronic periodontitis in the eastern Indian population. Majumder P et al. 2018 Bioscience reports
29481288 Replication Study Confirms the Association of the Common rs1800629 Variant of the TNFα Gene with Postmenopausal Osteoporosis Susceptibility in the Han Chinese Population. Jin X et al. 2018 Genetic testing and molecular biomarkers
29497291 <i>TNF</i> promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning. Reséndiz-Hernández JM et al. 2018 International journal of chronic obstructive pulmonary disease
29519182 Interactions among insulin resistance, inflammation factors, obesity-related gene polymorphisms, environmental risk factors, and diet in the development of gestational diabetes mellitus. Feng Y et al. 2019 The journal of maternal-fetal & neonatal medicine
29605608 Genetic variations in key inflammatory cytokines exacerbates the risk of diabetic nephropathy by influencing the gene expression. Hameed I et al. 2018 Gene
29611038 Tumor necrosis factor gene polymorphisms are associated with systemic lupus erythematosus susceptibility or lupus nephritis in Mexican patients. Ramírez-Bello J et al. 2018 Immunologic research
29624745 Atopic dermatitis: Interaction between genetic variants of GSTP1, TNF, TLR2, and TLR4 and air pollution in early life. Hüls A et al. 2018 Pediatric allergy and immunology
29673983 Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease. Oliveira M et al. 2018 Infection, genetics and evolution
29696068 Gene polymorphisms of TNF-238G/A, TNF-308G/A, IL10-1082G/A, TNFAIP3, and MC4R and comorbidity occurrence in a Romanian population with psoriasis. Voiculescu VM et al. 2018 Journal of medicine and life
29734056 Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian. Kumari R et al. 2018 Cytokine
29768622 Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil. Alvarado-Arnez LE et al. 2018 Memorias do Instituto Oswaldo Cruz
29846433 Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population. Chen J et al. 2018 Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
29849482 Influence of <i>TNF</i> and <i>IL17</i> Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population. Rocha Loures MA et al. 2018 Mediators of inflammation
29862067 Comparison of SNP Genotypes Related to Proliferative Vitreoretinopathy (PVR) across Slovenian and European Subpopulations. Lumi X et al. 2018 Journal of ophthalmology
29898681 Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(-) mothers. Cao MZ et al. 2018 BMC infectious diseases
29935877 Significant association between IL10-1082/-819 and TNF-308 haplotypes and the susceptibility to cervical carcinogenesis in women infected by Human papillomavirus. Chagas BS et al. 2019 Cytokine
29940817 The Correlation Between TNF-α Promoter Gene Polymorphism and Genetic Susceptibility to Cervical Cancer. Li X et al. 2018 Technology in cancer research & treatment
30009916 Single nucleotide polymorphisms in cytokine/chemokine genes are associated with severe infection, ulcer grade and amputation in diabetic foot ulcer. Viswanathan V et al. 2018 International journal of biological macromolecules
30027452 The Potential Role of TNF-α (rs361525 and rs1800629) in Hepatocellular Carcinoma: Multivariate Analysis (Meta-Analysis). Heidari Horestani M et al. 2019 Journal of gastrointestinal cancer
30109734 Polymorphisms in TH1-TH2 cytokine and receptor genes associated with risk of vertical HIV transmission, in Mumbai, India. Ahir-Bist S et al. 2018 The journal of gene medicine
30112393 Combination of Genetic Markers and Age Effectively Facilitates the Identification of People with High Risk of Preeclampsia in the Han Chinese Population. Zhou L et al. 2018 BioMed research international
30116153 Involvement of the IL23/Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus. Ben Jmaa M et al. 2018 Mediators of inflammation
30124928 TNF-α Stress Response Is Reduced Following Load Carriage Training. Jensen AE et al. 2019 Military medicine
30186498 Association of cytokine gene polymorphisms with osteoarthritis susceptibility. Rogoveanu OC et al. 2018 Experimental and therapeutic medicine
30204505 Impact of IL-27p28 (rs153109) and TNF-α (rs1800629) Genetic Polymorphisms on the Progression of HCV Infection in Egyptian Patients. Tharwat E et al. 2019 Immunological investigations
30206443 Genetic polymorphism in psoriasis and its meaning for the treatment efficacy in the future. Osmola-Mańkowska A et al. 2018 Postepy dermatologii i alergologii
30208882 Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis. Sode J et al. 2018 BMC medical genetics
30235774 Systematic meta-analysis of genetic variants associated with osteosarcoma susceptibility. Wang X et al. 2018 Medicine
30367528 DC-SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations. Alves Pereira Neto T et al. 2019 Mycoses
30383538 The influence of the <i>TNFα</i> rs1800629 polymorphism on some inflammatory biomarkers in 45-60-year-old women with metabolic syndrome. Szkup M et al. 2018 Aging
30412745 Genetic variations in inflammation-related genes and their influence on the susceptibility of pediatric acute lung injury in a Chinese population. Zhao X et al. 2019 Gene
30430914 Genetic polymorphism contributes to <sup>131</sup>I radiotherapy-induced toxicities in patients with differentiated thyroid cancer. Liu J et al. 2018 Pharmacogenomics
30475169 Association of Single Nucleotide Polymorphisms in <i>TNFA</i> and <i>IL10</i> Genes with Disease Severity in Influenza A/H1N1pdm09 Virus Infections: A Study from Western India. Choudhary ML et al. 2018 Viral immunology
30509964 A trial sequential meta-analysis of <i>TNF-</i>α -308G&gt;A (rs800629) gene polymorphism and susceptibility to colorectal cancer. Mandal RK et al. 2019 Bioscience reports
30557992 Association between rs1800629 polymorphism in tumor necrosis factor-α gene and dilated cardiomyopathy susceptibility: Evidence from case-control studies. Zhang Y et al. 2018 Medicine
30584432 Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study. Daneshpour MS et al. 2018 International journal of endocrinology and metabolism
30584776 Association of TNF, IL12, and IL23 gene polymorphisms and psoriatic arthritis: meta-analysis. Loures MAR et al. 2019 Expert review of clinical immunology
30595251 Tumor necrosis factor-alpha -308G/A gene polymorphism and novel biomarker profiles in patients with Takayasu arteritis. Sarkar PG et al. 2018 Indian heart journal
30610785 TNF-α-308G/A polymorphism and the risk of colorectal cancer: A systematic review and an updated meta-analysis. Miao Z et al. 2018 Journal of B.U.ON.
30662836 <i>TNF-α</i> gene polymorphisms: association with age-related macular degeneration in Russian population. Chernykh V et al. 2019 International journal of ophthalmology
30701793 Association between polymorphic markers in candidate genes and the risk of manifestationof endocrine ophthalmopathy in patients with Graves' disease. Petunina NA et al. 2018 Terapevticheskii arkhiv
30727925 Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A. Soori S et al. 2019 Cardiovascular & hematological disorders drug targets
30781715 Genetic Epidemiology of Breast Cancer in Latin America. Zavala VA et al. 2019 Genes
30792445 Polymorphisms of cytokine genes and tuberculosis in two independent studies. Wu S et al. 2019 Scientific reports
30793520 Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies. Tian J et al. 2019 Cancer medicine
30807515 SINGLE NUCLEOTIDE POLYMORPHISMS IN RETINAL DETACHMENT PATIENTS WITH AND WITHOUT PROLIFERATIVE VITREORETINOPATHY. Lumi X et al. 2020 Retina (Philadelphia, Pa.)
30813952 Genetic variability of inflammation and oxidative stress genes does not play a major role in the occurrence of adverse events of dopaminergic treatment in Parkinson's disease. Redenšek S et al. 2019 Journal of neuroinflammation
30815272 Genetic polymorphisms in tumour necrosis factor receptors (<i>TNFRSF1A/1B</i>) illustrate differential treatment response to TNFα inhibitors in patients with Crohn's disease. Qasem A et al. 2019 BMJ open gastroenterology
30843750 Genetic variants linked to folliculogenesis and successful pregnancy are not associated with twin births in a twins' town. Cardoso-Dos-Santos AC et al. 2020 The journal of maternal-fetal & neonatal medicine
30900134 TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women. Włodarczyk M et al. 2020 Molecular biology reports
30916218 Association between tumor necrosis factor polymorphisms and rheumatoid arthritis as well as systemic lupus erythematosus: a meta-analysis. Chen L et al. 2019 Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
30923465 SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren's syndrome. Ben-Eli H et al. 2019 Journal of inflammation (London, England)
30954991 Association of TLR4 and TNF-a Gene Polymorphisms and TLR4 mRNA Levels in Preterm Birth in a Northern Indian Population. Awasthi S et al. 2019 Indian pediatrics
30967802 Understanding the Relation Between Early-Life Adversity and Depression Symptoms: The Moderating Role of Sex and an Interleukin-1β Gene Variant. McQuaid RJ et al. 2019 Frontiers in psychiatry
30970058 Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion. Levy SC et al. 2019 Brazilian dental journal
30973927 Single nucleotide polymorphism analysis in interstitial cystitis/painful bladder syndrome. Cassão VD et al. 2019 PloS one
31023072 Symptom Science: Advocating for Inclusion of Functional Genetic Polymorphisms. Knisely MR et al. 2019 Biological research for nursing
31026237 Increasing Levels of Serum Heat Shock Protein 70 Precede the Development of AIDS-Defining Non-Hodgkin Lymphoma Among Carriers of HLA-B8-DR3. Aissani B et al. 2019 Journal of acquired immune deficiency syndromes (1999)
31044631 Association between Genetic Polymorphisms of Inflammatory Response Genes and Acute Pancreatitis. Rodriguez-Nicolas A et al. 2019 Immunological investigations
31046486 The study of methylation and single nucleotide polymorphisms of cancer-related genes in patients with early-stage ulcerative colitis. Chen HX et al. 2019 Scandinavian journal of gastroenterology
31054364 Multilocus associations of inflammatory genes with the risk of type 1 diabetes. Timasheva YR et al. 2019 Gene
31063409 Relationship Between Genetic Polymorphisms of the <i>TNF</i> Gene and Hallux Valgus Susceptibility. Yang J et al. 2019 Genetic testing and molecular biomarkers
31071395 The role of TNF-α and TLR4 polymorphisms in the placenta of pregnant women complicated by preeclampsia and in silico analysis. Mohammadpour-Gharehbagh A et al. 2019 International journal of biological macromolecules
31092242 Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population. Martínez-Campos C et al. 2019 BMC cancer
31129315 Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain. Chidambaran V et al. 2020 The journal of pain
31132515 Association of TNF-α gene alterations (c.-238G&gt;A, c.-308G&gt;A, c.-857C&gt;T, c.-863C&gt;A) with primary glaucoma in north Indian cohort. Passan S et al. 2019 Gene
31148856 Investigation of Immunovascular Polymorphisms and Intersections in Psoriasis. Urganci BE et al. 2019 Indian journal of dermatology
31210414 Association study of genetic variations of inflammatory biomarkers with susceptibility and severity of obstructive sleep apnea. Zhang Z et al. 2019 Molecular genetics & genomic medicine
31231424 Genetic and Epigenetic Studies in Diabetic Kidney Disease. Gu HF et al. 2019 Frontiers in genetics
31260854 TNF-α -308 G/A variant and susceptibility to chronic obstructive pulmonary disease: A systematic review and meta-analysis. Salimi Asl M et al. 2019 Cytokine
31261506 TLR4/NF-κB signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes. Ding Y et al. 2019 Medicine
31272196 Cytokine Genetic Variants and Health-Related Quality of Life in Crohn's Disease: An Exploratory Study. Knisely MR et al. 2019 Biological research for nursing
31324728 Association study of a functional variant of TNF-α gene and serum TNF-α level with the susceptibility of congenital heart disease in a Chinese population. Pan J et al. 2019 Postgraduate medical journal
31342641 Single-nucleotide polymorphisms associated with pemphigus vulgaris: Potent markers for better treatment and personalized medicine. Mahmoudi H et al. 2020 International journal of immunogenetics
31350695 Year-Long Rhinovirus Infection is Influenced by Atmospheric Conditions, Outdoor Air Virus Presence, and Immune System-Related Genetic Polymorphisms. Rodrigues AF et al. 2019 Food and environmental virology
31373163 Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia. Bănescu C et al. 2019 Cancer medicine
31396258 Host Genetics of Cytomegalovirus Pathogenesis. Sezgin E et al. 2019 Frontiers in genetics
31454695 Gene polymorphisms and circulating levels of the TNF-alpha are associated with ischemic stroke: A meta-analysis based on 19,873 individuals. Wu JC et al. 2019 International immunopharmacology
31479868 Association of single nucleotide polymorphisms in TNFA and CCR5 genes with Japanese Encephalitis: A study from an endemic region of North India. Deval H et al. 2019 Journal of neuroimmunology
31594215 Association between tumor necrosis factor-alpha gene rs1800629 (-308G/A) and rs361525 (-238G &gt; A) polymorphisms and prostate cancer risk in an Iranian cohort. Alidoost S et al. 2020 Human antibodies
31615448 Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysis. Zhu S et al. 2019 BMC gastroenterology
31624424 Association of the TNF-<i>α</i> -308G/A polymorphism with lipid profile changes in response to aerobic training program. Leońska-Duniec A et al. 2019 Biology of sport
31652851 The Association of Serum TNF-α Levels and Blood Multi-Elements Modified by TNF-α Gene Polymorphisms in Metal Industrial Workers. Chen TH et al. 2019 International journal of environmental research and public health
31738572 Genetic Distribution of the <i>LTA</i> +252 A&gt;G and <i>TNFA</i> -308 G &gt; A Polymorphisms in the Moroccan Population. Aznag FZ et al. 2019 Genetic testing and molecular biomarkers
31816580 Association between polymorphisms of cytokine genes and brucellosis: A comprehensive systematic review and meta-analysis. Zafari P et al. 2020 Cytokine
31817071 Polymorphisms in <i>TNF Receptor Superfamily 1B</i> (<i>TNFRSF1B:rs3397</i>) are Linked to <i>Mycobacterium avium paratuberculosis</i> Infection and Osteoporosis in Rheumatoid Arthritis. Naser A et al. 2019 Microorganisms
31819588 Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case-Control Study. Al-Eitan LN et al. 2019 The application of clinical genetics
31861518 Genetic Associations with Aging Muscle: A Systematic Review. Pratt J et al. 2019 Cells
31884867 Association of TNF-<i>α</i> rs1800629, CASP3 rs72689236 and FCGR2A rs1801274 Polymorphisms with Susceptibility to Kawasaki Disease: A Comprehensive Meta-Analysis. Ferdosian F et al. 2019 Fetal and pediatric pathology
31886296 Impact of SNPs/Haplotypes of <i>IL10</i> and <i>IFNG</i> on the Development of Diffuse Large B-Cell Lymphoma. Marangon AV et al. 2019 Journal of immunology research
31887189 Important gene-gene interaction of TNF-α and VDR on osteoporosis in community-dwelling elders. Liao LN et al. 2019 PloS one
31912349 Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder. Bialek K et al. 2020 Cellular and molecular neurobiology
31936215 Modelling the Effects of MCM7 Variants, Somatic Mutations, and Clinical Features on Acute Myeloid Leukemia Susceptibility and Prognosis. Tripon F et al. 2020 Journal of clinical medicine
31943768 Association of hepatocellular carcinoma risk with polymorphisms in tumour necrosis factor alpha gene in a Chinese Han population. Yue X et al. 2020 International journal of immunogenetics
31983162 Association between PSCA, TNF-α, PARP1 and TP53 Gene Polymorphisms and Gastric Cancer Susceptibility in the Brazilian Population. Dantas RN et al. 2020 Asian Pacific journal of cancer prevention
32074604 Association Analysis of Tumor Necrosis Factor Alpha Promoter Polymorphisms and Vitiligo Susceptibility in South Indian Tamils. Rajendiran KS et al. 2020 Dermatology (Basel, Switzerland)
32083395 Genetic variants in rheumatic fever and rheumatic heart disease. Muhamed B et al. 2020 American journal of medical genetics. Part C, Seminars in medical genetics
32115620 Associations of TNF-α -308 G&gt;A and TNF-β 252 A&gt;G with Physical Function and BNP-Rugao Longevity and Ageing Study. Yao S et al. 2020 The journal of nutrition, health & aging
32124801 SNPs and transcriptional activity of genes of innate and adaptive immunity at the maternal-fetal interface in woman with preterm labour, associated with preterm premature rupture of membranes. Lyubomirskaya ES et al. 2020 Wiadomosci lekarskie (Warsaw, Poland
32130979 TNF-α polymorphisms might influence predisposition to periodontitis: A meta-analysis. Li Y et al. 2020 Microbial pathogenesis
32162036 Genetic polymorphisms and multiple myeloma risk: a meta-analysis. Zhang P et al. 2020 Annals of hematology
32186960 Study of the association of seventeen single nucleotide polymorphisms and their haplotypes in the <i>TNF-α, IL-2, IL-4</i> and <i>IL-10</i> genes with the antibody response to inactivated Japanese encephalitis vaccine. Yao Y et al. 2020 Human vaccines & immunotherapeutics
Help

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post565+e32b82c