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dbSNP Short Genetic Variations

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs17782313

Current Build 153

Released July 9, 2019

Organism
Homo sapiens
Position
chr18:60183864 (GRCh38.p12) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
T>C
Variation Type
SNV Single Nucleotide Variation
Frequency
C=0.24113 (30278/125568, TOPMED)
C=0.2180 (17157/78698, PAGE_STUDY)
C=0.2274 (7133/31362, GnomAD) (+ 6 more)
C=0.240 (1202/5008, 1000G)
C=0.188 (841/4480, Estonian)
C=0.231 (892/3854, ALSPAC)
C=0.235 (870/3708, TWINSUK)
C=0.26 (154/600, NorthernSweden)
C=0.14 (30/216, Vietnamese)
Clinical Significance
Reported in ClinVar
Gene : Consequence
None
Publications
195 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p12 chr 18 NC_000018.10:g.60183864T>C
GRCh37.p13 chr 18 NC_000018.9:g.57851097T>C
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Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: C (allele ID: 227796 )
ClinVar Accession Disease Names Clinical Significance
RCV000211281.1 antipsychotics response - Toxicity/ADR Drug-Response
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Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 125568 T=0.75887 C=0.24113
The PAGE Study Global Study-wide 78698 T=0.7820 C=0.2180
The PAGE Study AfricanAmerican Sub 32514 T=0.7205 C=0.2795
The PAGE Study Mexican Sub 10808 T=0.8876 C=0.1124
The PAGE Study Asian Sub 8318 T=0.793 C=0.207
The PAGE Study PuertoRican Sub 7918 T=0.781 C=0.219
The PAGE Study NativeHawaiian Sub 4534 T=0.882 C=0.118
The PAGE Study Cuban Sub 4230 T=0.797 C=0.203
The PAGE Study Dominican Sub 3828 T=0.751 C=0.249
The PAGE Study CentralAmerican Sub 2450 T=0.891 C=0.109
The PAGE Study SouthAmerican Sub 1982 T=0.878 C=0.122
The PAGE Study NativeAmerican Sub 1260 T=0.813 C=0.187
The PAGE Study SouthAsian Sub 856 T=0.64 C=0.36
gnomAD - Genomes Global Study-wide 31362 T=0.7726 C=0.2274
gnomAD - Genomes European Sub 18896 T=0.7850 C=0.2150
gnomAD - Genomes African Sub 8682 T=0.722 C=0.278
gnomAD - Genomes East Asian Sub 1560 T=0.821 C=0.179
gnomAD - Genomes Other Sub 1086 T=0.802 C=0.198
gnomAD - Genomes American Sub 848 T=0.87 C=0.13
gnomAD - Genomes Ashkenazi Jewish Sub 290 T=0.81 C=0.19
1000Genomes Global Study-wide 5008 T=0.760 C=0.240
1000Genomes African Sub 1322 T=0.722 C=0.278
1000Genomes East Asian Sub 1008 T=0.813 C=0.187
1000Genomes Europe Sub 1006 T=0.760 C=0.240
1000Genomes South Asian Sub 978 T=0.68 C=0.32
1000Genomes American Sub 694 T=0.87 C=0.13
Genetic variation in the Estonian population Estonian Study-wide 4480 T=0.812 C=0.188
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 T=0.769 C=0.231
UK 10K study - Twins TWIN COHORT Study-wide 3708 T=0.765 C=0.235
Northern Sweden ACPOP Study-wide 600 T=0.74 C=0.26
A Vietnamese Genetic Variation Database Global Study-wide 216 T=0.86 C=0.14
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Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement T= C Note
GRCh38.p12 chr 18 NC_000018.10:g.60183864= NC_000018.10:g.60183864T>C
GRCh37.p13 chr 18 NC_000018.9:g.57851097= NC_000018.9:g.57851097T>C
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

118 SubSNP, 9 Frequency, 1 ClinVar submissions
No Submitter Submission ID Date (Build)
1 PERLEGEN ss24204960 Sep 20, 2004 (123)
2 ABI ss40918833 Mar 13, 2006 (126)
3 AFFY ss66408734 Dec 02, 2006 (127)
4 PERLEGEN ss69216652 May 18, 2007 (127)
5 AFFY ss76164541 Dec 06, 2007 (129)
6 HGSV ss81268508 Dec 15, 2007 (130)
7 KRIBB_YJKIM ss83282297 Dec 15, 2007 (130)
8 HUMANGENOME_JCVI ss96517090 Feb 05, 2009 (130)
9 1000GENOMES ss110657022 Jan 25, 2009 (130)
10 1000GENOMES ss114492360 Jan 25, 2009 (130)
11 ILLUMINA-UK ss117901948 Feb 14, 2009 (130)
12 ENSEMBL ss139743292 Dec 01, 2009 (131)
13 GMI ss155269009 Dec 01, 2009 (131)
14 ILLUMINA ss160457539 Dec 01, 2009 (131)
15 COMPLETE_GENOMICS ss168352549 Jul 04, 2010 (132)
16 COMPLETE_GENOMICS ss171872218 Jul 04, 2010 (132)
17 AFFY ss172685769 Jul 04, 2010 (132)
18 PAGE_STUDY ss181341899 Jul 04, 2010 (132)
19 PAGE_STUDY ss181834320 Jul 04, 2010 (132)
20 PAGE_STUDY ss181835986 Jul 04, 2010 (132)
21 PAGE_STUDY ss182258810 Jul 04, 2010 (132)
22 PAGE_STUDY ss182258840 Jul 04, 2010 (132)
23 BUSHMAN ss203360158 Jul 04, 2010 (132)
24 1000GENOMES ss227908543 Jul 14, 2010 (132)
25 1000GENOMES ss237502590 Jul 15, 2010 (132)
26 1000GENOMES ss243744307 Jul 15, 2010 (132)
27 GMI ss283024457 May 04, 2012 (137)
28 GMI ss287298760 Apr 25, 2013 (138)
29 PJP ss292086289 May 09, 2011 (134)
30 ILLUMINA ss410826104 Sep 17, 2011 (135)
31 ILLUMINA ss480284519 May 04, 2012 (137)
32 ILLUMINA ss480295747 May 04, 2012 (137)
33 ILLUMINA ss481045951 Sep 08, 2015 (146)
34 ILLUMINA ss484940216 May 04, 2012 (137)
35 EXOME_CHIP ss491533993 May 04, 2012 (137)
36 ILLUMINA ss536985694 Sep 08, 2015 (146)
37 TISHKOFF ss565698114 Apr 25, 2013 (138)
38 SSMP ss661533837 Apr 25, 2013 (138)
39 ILLUMINA ss778839842 Sep 08, 2015 (146)
40 ILLUMINA ss780682547 Sep 08, 2015 (146)
41 ILLUMINA ss782916405 Sep 08, 2015 (146)
42 ILLUMINA ss783355900 Sep 08, 2015 (146)
43 ILLUMINA ss783879549 Sep 08, 2015 (146)
44 ILLUMINA ss832171459 Sep 08, 2015 (146)
45 ILLUMINA ss834300380 Sep 08, 2015 (146)
46 EVA-GONL ss993823438 Aug 21, 2014 (142)
47 JMKIDD_LAB ss1081570784 Aug 21, 2014 (142)
48 1000GENOMES ss1361383936 Aug 21, 2014 (142)
49 HAMMER_LAB ss1397748436 Sep 08, 2015 (146)
50 DDI ss1428247445 Apr 01, 2015 (144)
51 EVA_GENOME_DK ss1578442875 Apr 01, 2015 (144)
52 EVA_UK10K_ALSPAC ss1637072142 Apr 01, 2015 (144)
53 EVA_UK10K_TWINSUK ss1680066175 Apr 01, 2015 (144)
54 EVA_DECODE ss1697885263 Apr 01, 2015 (144)
55 EVA_SVP ss1713633186 Apr 01, 2015 (144)
56 ILLUMINA ss1752262154 Sep 08, 2015 (146)
57 ILLUMINA ss1752262155 Sep 08, 2015 (146)
58 HAMMER_LAB ss1809091164 Sep 08, 2015 (146)
59 ILLUMINA ss1917927933 Feb 12, 2016 (147)
60 WEILL_CORNELL_DGM ss1937291195 Feb 12, 2016 (147)
61 ILLUMINA ss1946507519 Feb 12, 2016 (147)
62 ILLUMINA ss1946507522 Feb 12, 2016 (147)
63 ILLUMINA ss1959811180 Feb 12, 2016 (147)
64 ILLUMINA ss1959811181 Feb 12, 2016 (147)
65 GENOMED ss1968545792 Jul 19, 2016 (147)
66 JJLAB ss2029416393 Sep 14, 2016 (149)
67 ILLUMINA ss2094802973 Dec 20, 2016 (150)
68 ILLUMINA ss2095081235 Dec 20, 2016 (150)
69 USC_VALOUEV ss2157923959 Dec 20, 2016 (150)
70 HUMAN_LONGEVITY ss2222317303 Dec 20, 2016 (150)
71 TOPMED ss2387720541 Dec 20, 2016 (150)
72 SYSTEMSBIOZJU ss2629206586 Nov 08, 2017 (151)
73 ILLUMINA ss2633484652 Nov 08, 2017 (151)
74 ILLUMINA ss2633484653 Nov 08, 2017 (151)
75 ILLUMINA ss2633484654 Nov 08, 2017 (151)
76 GRF ss2702516223 Nov 08, 2017 (151)
77 ILLUMINA ss2710870524 Nov 08, 2017 (151)
78 GNOMAD ss2957696220 Nov 08, 2017 (151)
79 AFFY ss2985120210 Nov 08, 2017 (151)
80 AFFY ss2985758784 Nov 08, 2017 (151)
81 SWEGEN ss3016673286 Nov 08, 2017 (151)
82 ILLUMINA ss3021850998 Nov 08, 2017 (151)
83 ILLUMINA ss3021850999 Nov 08, 2017 (151)
84 BIOINF_KMB_FNS_UNIBA ss3028538207 Nov 08, 2017 (151)
85 TOPMED ss3281617294 Nov 08, 2017 (151)
86 CSHL ss3352066184 Nov 08, 2017 (151)
87 ILLUMINA ss3625727185 Oct 12, 2018 (152)
88 ILLUMINA ss3627830157 Oct 12, 2018 (152)
89 ILLUMINA ss3627830158 Oct 12, 2018 (152)
90 ILLUMINA ss3631460734 Oct 12, 2018 (152)
91 ILLUMINA ss3633165841 Oct 12, 2018 (152)
92 ILLUMINA ss3633874754 Oct 12, 2018 (152)
93 ILLUMINA ss3634710047 Oct 12, 2018 (152)
94 ILLUMINA ss3634710048 Oct 12, 2018 (152)
95 ILLUMINA ss3635561975 Oct 12, 2018 (152)
96 ILLUMINA ss3636399933 Oct 12, 2018 (152)
97 ILLUMINA ss3637313600 Oct 12, 2018 (152)
98 ILLUMINA ss3640417355 Oct 12, 2018 (152)
99 ILLUMINA ss3640417356 Oct 12, 2018 (152)
100 ILLUMINA ss3644707898 Oct 12, 2018 (152)
101 ILLUMINA ss3644707899 Oct 12, 2018 (152)
102 URBANLAB ss3650809934 Oct 12, 2018 (152)
103 ILLUMINA ss3652273522 Oct 12, 2018 (152)
104 ILLUMINA ss3652273523 Oct 12, 2018 (152)
105 ILLUMINA ss3653892364 Oct 12, 2018 (152)
106 EGCUT_WGS ss3683520707 Jul 13, 2019 (153)
107 EVA_DECODE ss3701838653 Jul 13, 2019 (153)
108 ILLUMINA ss3725683775 Jul 13, 2019 (153)
109 ACPOP ss3742623196 Jul 13, 2019 (153)
110 ILLUMINA ss3744160114 Jul 13, 2019 (153)
111 ILLUMINA ss3744454825 Jul 13, 2019 (153)
112 ILLUMINA ss3745010177 Jul 13, 2019 (153)
113 ILLUMINA ss3745010178 Jul 13, 2019 (153)
114 EVA ss3755503712 Jul 13, 2019 (153)
115 PAGE_CC ss3771977335 Jul 13, 2019 (153)
116 ILLUMINA ss3772507631 Jul 13, 2019 (153)
117 ILLUMINA ss3772507632 Jul 13, 2019 (153)
118 KHV_HUMAN_GENOMES ss3820758681 Jul 13, 2019 (153)
119 1000Genomes NC_000018.9 - 57851097 Oct 12, 2018 (152)
120 The Avon Longitudinal Study of Parents and Children NC_000018.9 - 57851097 Oct 12, 2018 (152)
121 Genetic variation in the Estonian population NC_000018.9 - 57851097 Oct 12, 2018 (152)
122 gnomAD - Genomes NC_000018.9 - 57851097 Jul 13, 2019 (153)
123 Northern Sweden NC_000018.9 - 57851097 Jul 13, 2019 (153)
124 The PAGE Study NC_000018.10 - 60183864 Jul 13, 2019 (153)
125 TopMed NC_000018.10 - 60183864 Oct 12, 2018 (152)
126 UK 10K study - Twins NC_000018.9 - 57851097 Oct 12, 2018 (152)
127 A Vietnamese Genetic Variation Database NC_000018.9 - 57851097 Jul 13, 2019 (153)
128 ClinVar RCV000211281.1 Oct 12, 2018 (152)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs59090733 May 25, 2008 (130)
rs59781239 Feb 26, 2009 (130)
Added to this RefSNP Cluster:
Submission ids Observation SPDI Canonical SPDI Source RSIDs
ss66408734, ss76164541, ss81268508, ss110657022, ss114492360, ss117901948, ss168352549, ss171872218, ss172685769, ss203360158, ss283024457, ss287298760, ss292086289, ss480284519, ss1397748436, ss1697885263, ss1713633186 NC_000018.8:56002076:T:C NC_000018.10:60183863:T:C (self)
74725908, 41415066, 29258955, 203957091, 15908061, 41415066, 9150155, ss227908543, ss237502590, ss243744307, ss480295747, ss481045951, ss484940216, ss491533993, ss536985694, ss565698114, ss661533837, ss778839842, ss780682547, ss782916405, ss783355900, ss783879549, ss832171459, ss834300380, ss993823438, ss1081570784, ss1361383936, ss1428247445, ss1578442875, ss1637072142, ss1680066175, ss1752262154, ss1752262155, ss1809091164, ss1917927933, ss1937291195, ss1946507519, ss1946507522, ss1959811180, ss1959811181, ss1968545792, ss2029416393, ss2094802973, ss2095081235, ss2157923959, ss2387720541, ss2629206586, ss2633484652, ss2633484653, ss2633484654, ss2702516223, ss2710870524, ss2957696220, ss2985120210, ss2985758784, ss3016673286, ss3021850998, ss3021850999, ss3352066184, ss3625727185, ss3627830157, ss3627830158, ss3631460734, ss3633165841, ss3633874754, ss3634710047, ss3634710048, ss3635561975, ss3636399933, ss3637313600, ss3640417355, ss3640417356, ss3644707898, ss3644707899, ss3652273522, ss3652273523, ss3653892364, ss3683520707, ss3742623196, ss3744160114, ss3744454825, ss3745010177, ss3745010178, ss3755503712, ss3772507631, ss3772507632 NC_000018.9:57851096:T:C NC_000018.10:60183863:T:C (self)
RCV000211281.1, 1198804, 171821627, ss2222317303, ss3028538207, ss3281617294, ss3650809934, ss3701838653, ss3725683775, ss3771977335, ss3820758681 NC_000018.10:60183863:T:C NC_000018.10:60183863:T:C (self)
ss24204960, ss40918833, ss69216652, ss83282297, ss96517090, ss139743292, ss155269009, ss160457539, ss181341899, ss181834320, ss181835986, ss182258810, ss182258840, ss410826104 NT_025028.14:5641960:T:C NC_000018.10:60183863:T:C (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

195 citations for rs17782313
PMID Title Author Year Journal
18454148 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Loos RJ et al. 2008 Nature genetics
18682847 Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. Andreasen CH et al. 2008 PloS one
18697794 The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Qi L et al. 2008 Human molecular genetics
19016587 How does body fat influence bone mass in childhood? A Mendelian randomization approach. Timpson NJ et al. 2009 Journal of bone and mineral research
19060910 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Sabatti C et al. 2009 Nature genetics
19073769 Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes. Zobel DP et al. 2009 Diabetes
19079261 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Willer CJ et al. 2009 Nature genetics
19153581 Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. Stutzmann F et al. 2009 International journal of obesity (2005)
19164386 Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Renström F et al. 2009 Human molecular genetics
19197348 Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. Lowe JK et al. 2009 PLoS genetics
19255736 Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. Cauchi S et al. 2009 Journal of molecular medicine (Berlin, Germany)
19265794 Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry. Grant SF et al. 2009 Obesity (Silver Spring, Md.)
19470880 Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype. Timpson NJ et al. 2009 Hypertension (Dallas, Tex.
19526209 Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants? Southam L et al. 2009 Diabetologia
19553259 Common body mass index-associated variants confer risk of extreme obesity. Cotsapas C et al. 2009 Human molecular genetics
19557197 NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. Heard-Costa NL et al. 2009 PLoS genetics
19629057 Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss. Haupt A et al. 2009 Obesity (Silver Spring, Md.)
19668254 Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study. Tabara Y et al. 2009 International journal of obesity (2005)
19750184 Genome-wide association studies for atherosclerotic vascular disease and its risk factors. Ding K et al. 2009 Circulation. Cardiovascular genetics
19812171 Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Li S et al. 2010 The American journal of clinical nutrition
19822564 Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types. Cha S et al. 2011 Evidence-based complementary and alternative medicine
19844209 Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure. Kring SI et al. 2010 International journal of obesity (2005)
19880856 Life course variations in the associations between FTO and MC4R gene variants and body size. Hardy R et al. 2010 Human molecular genetics
19906786 Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. Welsh P et al. 2010 The Journal of clinical endocrinology and metabolism
19910641 Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. He M et al. 2010 Arteriosclerosis, thrombosis, and vascular biology
19915463 Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes. Qi L et al. 2010 Current opinion in lipidology
20017980 A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data. Luan J et al. 2009 BMC proceedings
20061430 Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population. Cheung CY et al. 2010 The Journal of clinical endocrinology and metabolism
20070976 Common variants near melanocortin 4 receptor are associated with general and visceral adiposity in European- and African-American youth. Liu G et al. 2010 The Journal of pediatrics
20092643 Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). Tan S et al. 2010 BMC medical genetics
20127379 From monogenic to polygenic obesity: recent advances. Hinney A et al. 2010 European child & adolescent psychiatry
20161779 Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. Wen J et al. 2010 PloS one
20181787 A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake. Hasselbalch AL et al. 2010 The Journal of nutrition
20215774 Association between a common variant near MC4R and change in body mass index develops by two weeks of age. Petry CJ et al. 2010 Hormone research in paediatrics
20386550 Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA. Holzapfel C et al. 2010 International journal of obesity (2005)
20397748 Genome-wide association study of height and body mass index in Australian twin families. Liu JZ et al. 2010 Twin research and human genetics
20406574 Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior. Valladares M et al. 2010 Nutritional neuroscience
20520848 Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. Elks CE et al. 2010 PLoS medicine
20616199 Evaluation of genetic susceptibility loci for obesity in Chinese women. Shi J et al. 2010 American journal of epidemiology
20616999 Usefulness of Mendelian randomization in observational epidemiology. Bochud M et al. 2010 International journal of environmental research and public health
20712903 Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. Morgan AR et al. 2010 BMC medical genetics
20724578 Evaluation of A2BP1 as an obesity gene. Ma L et al. 2010 Diabetes
20724581 Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. den Hoed M et al. 2010 Diabetes
20725061 MC4R variant is associated with BMI but not response to resistance training in young females. Orkunoglu-Suer FE et al. 2011 Obesity (Silver Spring, Md.)
20816152 Obesity and diabetes genetic variants associated with gestational weight gain. Stuebe AM et al. 2010 American journal of obstetrics and gynecology
20816195 Analyses of shared genetic factors between asthma and obesity in children. Melén E et al. 2010 The Journal of allergy and clinical immunology
20824172 Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. Li S et al. 2010 PLoS medicine
20843981 Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Wu L et al. 2010 Diabetes
20966902 Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. Croteau-Chonka DC et al. 2011 Obesity (Silver Spring, Md.)
21063808 Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations. Huang W et al. 2011 Endocrine
21085626 Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus. Scherag A et al. 2010 PloS one
21147891 Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study. Cheung CY et al. 2011 European journal of endocrinology
21150882 Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia. Karns R et al. 2011 European journal of human genetics
21152014 Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals. Andersson EA et al. 2010 PloS one
21210875 Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults. Lawlor DA et al. 2011 Journal of internal medicine
21267540 Genetic predisposition to obesity leads to increased risk of type 2 diabetes. Li S et al. 2011 Diabetologia
21283731 FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. Ewens KG et al. 2011 PloS one
21293879 A dynamic model for genome-wide association studies. Das K et al. 2011 Human genetics
21303735 Association study of MC4R with complex obesity and replication of the rs17782313 association signal. Beckers S et al. 2011 Molecular genetics and metabolism
21347432 The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. Lurie G et al. 2011 PloS one
21357383 No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies. Chen F et al. 2011 Cancer epidemiology, biomarkers & prevention
21372613 Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention. Vogel CI et al. 2011 Obesity facts
21466928 Genetics and epigenetics of obesity. Herrera BM et al. 2011 Maturitas
21526213 Genetic markers of obesity risk: stronger associations with body composition in overweight compared to normal-weight children. Beyerlein A et al. 2011 PloS one
21544599 Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth. Liu G et al. 2011 European journal of epidemiology
21573225 Genetic background of patients from a university medical center in Manhattan: implications for personalized medicine. Tayo BO et al. 2011 PloS one
21593506 Maternal and offspring adiposity-related genetic variants and gestational weight gain. Lawlor DA et al. 2011 The American journal of clinical nutrition
21688152 Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk. Kusinska R et al. 2012 Molecular biology reports
21695122 Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. Santos JL et al. 2011 PloS one
21701570 Genome-wide association of BMI in African Americans. Ng MC et al. 2012 Obesity (Silver Spring, Md.)
21750520 Implication of European-derived adiposity loci in African Americans. Hester JM et al. 2012 International journal of obesity (2005)
21773002 Mendelian Randomisation Study of Childhood BMI and Early Menarche. Mumby HS et al. 2011 Journal of obesity
21785715 Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier. Taylor AE et al. 2011 Journal of obesity
21787115 CHEK2, MGMT, SULT1E1 and SULT1A1 polymorphisms and endometrial cancer risk. O'Mara TA et al. 2011 Twin research and human genetics
21799482 Common genetic variants and central adiposity among Asian-Indians. Moore SC et al. 2012 Obesity (Silver Spring, Md.)
21818152 Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects. Hunt SC et al. 2011 Obesity (Silver Spring, Md.)
21976109 Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study. Delahanty RJ et al. 2011 American journal of epidemiology
22029802 Genetic risk score does not correlate with body mass index of Latina women in a clinical trial. Coenen KR et al. 2011 Clinical and translational science
22043165 Genetics of Obesity: What have we Learned? Choquet H et al. 2011 Current genomics
22051089 Associations of obesity genes with obesity-related outcomes in multiethnic children. Klimentidis YC et al. 2011 Archives of medical research
22083549 Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty. Wang J et al. 2012 International journal of obesity (2005)
22310352 Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene. Chowdhury NI et al. 2013 The pharmacogenomics journal
22328972 A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes. Lee YC et al. 2011 Journal of data mining in genomics & proteomics
22350153 A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population. Tao L et al. 2012 Molecular biology reports
22384102 A latent variable partial least squares path modeling approach to regional association and polygenic effect with applications to a human obesity study. Xue F et al. 2012 PloS one
22421923 Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians. Vasan SK et al. 2012 Obesity (Silver Spring, Md.)
22466342 β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals. Thomsen M et al. 2012 The Journal of clinical endocrinology and metabolism
22511254 Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies. Lim U et al. 2012 International journal of cancer
22614171 Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study. Lombard Z et al. 2012 BMJ open
22869321 Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals. Xi B et al. 2012 Diabetologia
22992668 Pharmacogenomics knowledge for personalized medicine. Whirl-Carrillo M et al. 2012 Clinical pharmacology and therapeutics
23049848 Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis. Xi B et al. 2012 PloS one
23054017 The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan. Yang CW et al. 2013 Molecular biology reports
23094032 Obesity-susceptibility loci and their influence on adiposity-related traits in transition from adolescence to adulthood--the HUNT study. Cuypers KF et al. 2012 PloS one
23101478 Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study. Povel CM et al. 2012 Cardiovascular diabetology
23130628 Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Ortega-Azorín C et al. 2012 Cardiovascular diabetology
23147118 Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review. Valette M et al. 2013 International journal of obesity (2005)
23201545 FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention. Zlatohlavek L et al. 2013 Clinical biochemistry
23236435 Fat mass and obesity associated gene (FTO) expression is regulated negatively by the transcription factor Foxa2. Guo J et al. 2012 PloS one
23277235 Association of the common MC4R rs17782313 polymorphism with antipsychotic-related weight gain. Czerwensky F et al. 2013 Journal of clinical psychopharmacology
23318717 Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway. Kvaløy K et al. 2013 International journal of obesity (2005)
23339409 Reduced genetic influence on childhood obesity in small for gestational age children. Han DY et al. 2013 BMC medical genetics
23447422 A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents. Vasan SK et al. 2013 Pediatric obesity
23460509 Replication of genetic effects of MC4R polymorphisms on body mass index in a Korean population. Sull JW et al. 2013 Endocrine
23577239 Genetics of obesity and type 2 diabetes in African Americans. McCormack S et al. 2013 Journal of obesity
23588626 Associations of obesity susceptibility loci with hypertension in Chinese children. Xi B et al. 2013 International journal of obesity (2005)
23712987 Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Fesinmeyer MD et al. 2013 Obesity (Silver Spring, Md.)
23775818 Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study. Stender S et al. 2013 Hepatology (Baltimore, Md.)
23799528 Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. Nurmi EL et al. 2013 Translational psychiatry
23849767 Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension. Marcadenti A et al. 2013 Cardiovascular diabetology
23920449 MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain? Czerwensky F et al. 2013 The international journal of neuropsychopharmacology
24091943 Interaction between obesity-related genes, FTO and MC4R, associated to an increase of breast cancer risk. da Cunha PA et al. 2013 Molecular biology reports
24139164 Melanocortin-4 receptor polymorphism rs17782313: association with obesity and eating in the absence of hunger in Chilean children. Ho-Urriola J et al. 2014 Nutrition (Burbank, Los Angeles County, Calif.)
24269186 An obesity genetic risk score is associated with metabolic syndrome in Chinese children. Zhao X et al. 2014 Gene
24307561 Preliminary findings on the influence of FTO rs9939609 and MC4R rs17782313 polymorphisms on resting energy expenditure, leptin and thyrotropin levels in obese non-morbid premenopausal women. Arrizabalaga M et al. 2014 Journal of physiology and biochemistry
24385306 The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity. Rovite V et al. 2014 Molecular biology reports
24458218 Association of INSIG2 rs9308762 with ALT level independent of BMI. Guan L et al. 2014 Journal of pediatric gastroenterology and nutrition
24458996 Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults. Acosta A et al. 2014 Genes & nutrition
24820477 Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. Evans DS et al. 2014 PloS one
24827639 Association between MC4R rs17782313 polymorphism and overeating behaviors. Yilmaz Z et al. 2015 International journal of obesity (2005)
24843659 Insights into the genetic basis of type 2 diabetes. Kato N et al. 2013 Journal of diabetes investigation
24879436 Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries. Tan LJ et al. 2014 PloS one
24880622 A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study. Katsuura-Kamano S et al. 2014 Endocrine
24885933 Towards the clinical implementation of pharmacogenetics in bipolar disorder. Salloum NC et al. 2014 BMC medicine
25377722 Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis. Feng Y et al. 2014 BMC infectious diseases
25430627 A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake. Goni L et al. 2015 Genes & nutrition
25637721 Genetic variations in SEC16B, MC4R, MAP2K5 and KCTD15 were associated with childhood obesity and interacted with dietary behaviors in Chinese school-age population. Lv D et al. 2015 Gene
25733959 Pharmacogenetics and outcome with antipsychotic drugs. Pouget JG et al. 2014 Dialogues in clinical neuroscience
25769385 The association of MC4R rs17782313 polymorphism with dietary intake in Iranian adults. Khalilitehrani A et al. 2015 Gene
25774817 Genetics of type 2 diabetes-pitfalls and possibilities. Prasad RB et al. 2015 Genes
25870980 Gene-Gene Interplay and Gene-Diet Interactions Involving the MTNR1B rs10830963 Variant with Body Weight Loss. Goni L et al. 2014 Journal of nutrigenetics and nutrigenomics
25929371 Independent and combined influence of the FTO rs9939609 and MC4Rrs17782313 polymorphisms on hypocaloric diet induced changes in body mass and composition and energy metabolism in non-morbid obese premenopausal women. Labayen I et al. 2015 Nutricion hospitalaria
25948074 Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort. Fernandes AE et al. 2015 Endocrine
26032905 Interaction between common variants of FTO and MC4R is associated with risk of PCOS. Yuan H et al. 2015 Reproductive biology and endocrinology
26162542 A common variant near BDNF is associated with dietary calcium intake in adolescents. Dušátková L et al. 2015 Nutrition research (New York, N.Y.)
26226973 Analysis of MC4R rs17782313, POMC rs1042571, APOE-Hha1 and AGRP rs3412352 genetic variants with susceptibility to obesity risk in North Indians. Srivastava A et al. 2016 Annals of human biology
26324055 Combined effects of FTO rs9939609 and MC4R rs17782313 on elevated nocturnal blood pressure in the Chinese Han population. Sun Y et al. 2016 Cardiovascular journal of Africa
26495240 Obesity-Related Genetic Variants and their Associations with Physical Activity. Lee H et al. 2015 Sports medicine - open
26504195 Obese individuals experience wheezing without asthma but not asthma without wheezing: a Mendelian randomisation study of 85,437 adults from the Copenhagen General Population Study. Çolak Y et al. 2016 Thorax
26543368 Epidemiological support for genetic variability at hypothalamic-pituitary-adrenal axis and serotonergic system as risk factors for major depression. Ching-López A et al. 2015 Neuropsychiatric disease and treatment
26588347 Melanocortin-4 Receptor Gene Variation Is Associated with Eating Behavior in Chilean Adults. Vega JA et al. 2016 Annals of nutrition & metabolism
26691922 Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases. Melnik BC et al. 2015 Journal of translational medicine
26788058 Role of FTO in Adipocyte Development and Function: Recent Insights. Merkestein M et al. 2015 International journal of endocrinology
26848030 Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population. Wang T et al. 2016 Scientific reports
26866580 The Geisinger MyCode community health initiative: an electronic health record-linked biobank for precision medicine research. Carey DJ et al. 2016 Genetics in medicine
26880915 Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents. Dos Santos-Júnior A et al. 2016 International journal of endocrinology
26907388 Relation of FTO gene variants to fetal growth trajectories: Findings from the Southampton Women's survey. Barton SJ et al. 2016 Placenta
26930408 Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity. Larsen SC et al. 2016 PloS one
27118560 High body mass index and risk of exacerbations and pneumonias in individuals with chronic obstructive pulmonary disease: observational and genetic risk estimates from the Copenhagen General Population Study. Çolak Y et al. 2016 International journal of epidemiology
27147943 Neuroendorine and Epigentic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic Syndrome. Lemche E et al. 2016 Frontiers in neuroscience
27168919 Association of FTO rs9939609 SNP with Obesity and Obesity- Associated Phenotypes in a North Indian Population. Prakash J et al. 2016 Oman medical journal
27186233 The effect of interaction between Melanocortin-4 receptor polymorphism and dietary factors on the risk of metabolic syndrome. Koochakpoor G et al. 2016 Nutrition & metabolism
27213003 Interactions with the MC4R rs17782313 variant, mental stress and energy intake and the risk of obesity in Genome Epidemiology Study. Park S et al. 2016 Nutrition & metabolism
27217270 Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis. Zhang JP et al. 2016 Schizophrenia bulletin
27274759 Interaction between FTO gene variants and lifestyle factors on metabolic traits in an Asian Indian population. Vimaleswaran KS et al. 2016 Nutrition & metabolism
27351487 Obesity and Multiple Sclerosis: A Mendelian Randomization Study. Mokry LE et al. 2016 PLoS medicine
27465381 Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts. Brunkwall L et al. 2016 The American journal of clinical nutrition
27486100 Assessing the effects of 35 European-derived BMI-associated SNPs in Mexican children. Abadi A et al. 2016 Obesity (Silver Spring, Md.)
27598147 Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention. Fitó M et al. 2016 International journal of molecular sciences
27601774 Genetic variants influencing effectiveness of exercise training programmes in obesity - an overview of human studies. Leońska-Duniec A et al. 2016 Biology of sport
27701175 Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population. Song Z et al. 2016 Obesity facts
27730429 Association of the melanocortin 4 receptor gene rs17782313 polymorphism with rewarding value of food and eating behavior in Chilean children. Obregón AM et al. 2017 Journal of physiology and biochemistry
27853387 Treatment-resistant schizophrenia: current insights on the pharmacogenomics of antipsychotics. Lally J et al. 2016 Pharmacogenomics and personalized medicine
27920511 Relationships between <i>FTO</i> rs9939609, <i>MC4R</i> rs17782313, and <i>PPARγ</i> rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men - a preliminary study. Rotter I et al. 2016 Clinical interventions in aging
28081251 Physical Activity and Sedentary Behaviors Modify the Association between Melanocortin 4 Receptor Gene Variant and Obesity in Chinese Children and Adolescents. Song JY et al. 2017 PloS one
28090739 Obesity-related genetic polymorphisms and adiposity indices in a young Italian population. Bordoni L et al. 2017 IUBMB life
28133617 Molecular Analysis of a Genetic Variants Panel Related to Nutrients and Metabolism: Association with Susceptibility to Gestational Diabetes and Cardiometabolic Risk in Affected Women. Franzago M et al. 2017 Journal of diabetes research
28150230 Melanocortin Receptor-4 Gene Polymorphisms in Glioblastoma Patients Treated with Concomitant Radio-Chemotherapy. Pasqualetti F et al. 2018 Molecular neurobiology
28209224 Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Webb TR et al. 2017 Journal of the American College of Cardiology
28356726 Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T&gt;C) polymorphism of the <i>MC4R</i> gene in postmenopausal women. Brodowski J et al. 2017 Clinical interventions in aging
28384342 Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study. Bjørnland T et al. 2017 PloS one
28396685 Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children. Wu L et al. 2017 International journal of endocrinology
28533660 Genes, emotions and gut microbiota: The next frontier for the gastroenterologist. Panduro A et al. 2017 World journal of gastroenterology
28579220 The polymorphism rs17782313 near MC4R gene is related with anthropometric changes in women submitted to bariatric surgery over 60 months. Resende CMM et al. 2018 Clinical nutrition (Edinburgh, Scotland)
28636007 Analysis of association of gene variants with obesity traits in New Zealand European children at 6 years of age. Krishnan M et al. 2017 Molecular bioSystems
28693089 [Effect of genetic polymorphisms on change in body mass index and obesity status during childhood]. Zhang MX et al. 2017 Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
28738459 [Gene-gene interaction on central obesity in school-aged children in China]. Fu LW et al. 2017 Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
28799434 Metabolic biomarkers and gallstone disease - a population-based study. Shabanzadeh DM et al. 2017 Scandinavian journal of gastroenterology
28828082 Impact of the Polymorphism Near <i>MC4R</i> (rs17782313) on Obesity- and Metabolic-Related Traits in Women Participating in an Aerobic Training Program. Leońska-Duniec A et al. 2017 Journal of human kinetics
28975585 Polymorphisms in Genes Involved in the Leptin-Melanocortin Pathway are Associated with Obesity-Related Cardiometabolic Alterations in a Southern Chilean Population. Manriquez V et al. 2018 Molecular diagnosis & therapy
29182660 Interaction between TCF7L2 polymorphism and dietary fat intake on high density lipoprotein cholesterol. Bodhini D et al. 2017 PloS one
29315078 Associations between the components of metabolic syndrome and the polymorphisms in the peroxisome proliferator-activated receptor gamma (<i>PPAR-γ</i>), the fat mass and obesity-associated (<i>FTO</i>), and the melanocortin-4 receptor (<i>MC4R</i>) genes. Szkup M et al. 2018 Aging
29325775 Nutrigenetic variants and cardio-metabolic risk in women with or without gestational diabetes. Franzago M et al. 2018 Diabetes research and clinical practice
29334686 Fat Mass and Obesity-Related Gene Variants rs9939609 and rs7185735 are Associated with Second-Generation Antipsychotic-Induced Weight Gain. Schröder C et al. 2019 Pharmacopsychiatry
29466028 Analysis of the Impact of Common Polymorphisms of the FTO and MC4R Genes with the Risk of Severe Obesity in Saudi Arabian Population. Cyrus C et al. 2018 Genetic testing and molecular biomarkers
29679223 Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children. Almeida SM et al. 2018 Endocrine
29686896 The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women. Meng Y et al. 2018 Journal of nutrition and metabolism
29696068 Gene polymorphisms of TNF-238G/A, TNF-308G/A, IL10-1082G/A, TNFAIP3, and MC4R and comorbidity occurrence in a Romanian population with psoriasis. Voiculescu VM et al. 2018 Journal of medicine and life
29893663 Associations between obesity candidate gene polymorphisms (fat mass and obesity-associated (FTO), melanocortin-4 receptor (MC4R), leptin (LEP) and leptin receptor (LEPR)) and dietary intake in pregnant women. Martins MC et al. 2018 The British journal of nutrition
30032228 Associations between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review. Drabsch T et al. 2018 Advances in nutrition (Bethesda, Md.)
30671185 Evaluation of <i>FTO</i> rs9939609 and <i>MC4R</i> rs17782313 Polymorphisms as Prognostic Biomarkers of Obesity: A Population-based Cross-sectional Study. Mozafarizadeh M et al. 2019 Oman medical journal
30896429 Combined effect of FTO and MC4R gene polymorphisms on obesity in children and adolescents in Northwest China: a case-control study. Yang Y et al. 2019 Asia Pacific journal of clinical nutrition
30929193 Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance. Zhang Y et al. 2019 Science China. Life sciences
30945034 The MC4R genetic variants are associated with lower visceral fat accumulation and higher postprandial relative increase in carbohydrate utilization in humans. Adamska-Patruno E et al. 2019 European journal of nutrition
31213864 The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population. da Fonseca ACP et al. 2019 Diabetes, metabolic syndrome and obesity

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
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