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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs165774

Current Build 155

Released April 9, 2021

Organism
Homo sapiens
Position
chr22:19965038 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
G>A
Variation Type
SNV Single Nucleotide Variation
Frequency
A=0.259519 (68692/264690, TOPMED)
A=0.268945 (37691/140144, GnomAD)
A=0.295279 (35773/121150, ALFA) (+ 17 more)
A=0.16068 (2693/16760, 8.3KJPN)
A=0.2031 (1017/5008, 1000G)
A=0.3112 (1394/4480, Estonian)
A=0.3038 (1171/3854, ALSPAC)
A=0.3023 (1121/3708, TWINSUK)
A=0.1386 (405/2922, KOREAN)
A=0.2039 (425/2084, HGDP_Stanford)
A=0.1288 (236/1832, Korea1K)
A=0.2315 (369/1594, HapMap)
A=0.311 (310/998, GoNL)
A=0.093 (72/774, PRJEB37584)
A=0.292 (175/600, NorthernSweden)
G=0.431 (94/218, SGDP_PRJ)
A=0.347 (75/216, Qatari)
A=0.167 (36/216, Vietnamese)
G=0.48 (20/42, Ancient Sardinia)
G=0.46 (12/26, Siberian)
Clinical Significance
Not Reported in ClinVar
Gene : Consequence
COMT : Intron Variant
Publications
20 citations
Genomic View
See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 121150 G=0.704721 A=0.295279
European Sub 98852 G=0.68625 A=0.31375
African Sub 6498 G=0.7856 A=0.2144
African Others Sub 236 G=0.818 A=0.182
African American Sub 6262 G=0.7844 A=0.2156
Asian Sub 562 G=0.854 A=0.146
East Asian Sub 482 G=0.851 A=0.149
Other Asian Sub 80 G=0.88 A=0.12
Latin American 1 Sub 674 G=0.749 A=0.251
Latin American 2 Sub 5534 G=0.8220 A=0.1780
South Asian Sub 5016 G=0.8046 A=0.1954
Other Sub 4014 G=0.7138 A=0.2862


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 G=0.740481 A=0.259519
gnomAD - Genomes Global Study-wide 140144 G=0.731055 A=0.268945
gnomAD - Genomes European Sub 75872 G=0.69019 A=0.30981
gnomAD - Genomes African Sub 42004 G=0.78100 A=0.21900
gnomAD - Genomes American Sub 13660 G=0.78346 A=0.21654
gnomAD - Genomes Ashkenazi Jewish Sub 3324 G=0.6853 A=0.3147
gnomAD - Genomes East Asian Sub 3132 G=0.8633 A=0.1367
gnomAD - Genomes Other Sub 2152 G=0.7426 A=0.2574
Allele Frequency Aggregator Total Global 121150 G=0.704721 A=0.295279
Allele Frequency Aggregator European Sub 98852 G=0.68625 A=0.31375
Allele Frequency Aggregator African Sub 6498 G=0.7856 A=0.2144
Allele Frequency Aggregator Latin American 2 Sub 5534 G=0.8220 A=0.1780
Allele Frequency Aggregator South Asian Sub 5016 G=0.8046 A=0.1954
Allele Frequency Aggregator Other Sub 4014 G=0.7138 A=0.2862
Allele Frequency Aggregator Latin American 1 Sub 674 G=0.749 A=0.251
Allele Frequency Aggregator Asian Sub 562 G=0.854 A=0.146
8.3KJPN JAPANESE Study-wide 16760 G=0.83932 A=0.16068
1000Genomes Global Study-wide 5008 G=0.7969 A=0.2031
1000Genomes African Sub 1322 G=0.7920 A=0.2080
1000Genomes East Asian Sub 1008 G=0.8532 A=0.1468
1000Genomes Europe Sub 1006 G=0.6948 A=0.3052
1000Genomes South Asian Sub 978 G=0.818 A=0.182
1000Genomes American Sub 694 G=0.843 A=0.157
Genetic variation in the Estonian population Estonian Study-wide 4480 G=0.6888 A=0.3112
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 G=0.6962 A=0.3038
UK 10K study - Twins TWIN COHORT Study-wide 3708 G=0.6977 A=0.3023
KOREAN population from KRGDB KOREAN Study-wide 2922 G=0.8614 A=0.1386
HGDP-CEPH-db Supplement 1 Global Study-wide 2084 G=0.7961 A=0.2039
HGDP-CEPH-db Supplement 1 Est_Asia Sub 470 G=0.879 A=0.121
HGDP-CEPH-db Supplement 1 Central_South_Asia Sub 414 G=0.744 A=0.256
HGDP-CEPH-db Supplement 1 Middle_Est Sub 350 G=0.706 A=0.294
HGDP-CEPH-db Supplement 1 Europe Sub 320 G=0.684 A=0.316
HGDP-CEPH-db Supplement 1 Africa Sub 242 G=0.789 A=0.211
HGDP-CEPH-db Supplement 1 America Sub 216 G=0.991 A=0.009
HGDP-CEPH-db Supplement 1 Oceania Sub 72 G=0.93 A=0.07
Korean Genome Project KOREAN Study-wide 1832 G=0.8712 A=0.1288
HapMap Global Study-wide 1594 G=0.7685 A=0.2315
HapMap American Sub 770 G=0.790 A=0.210
HapMap African Sub 402 G=0.771 A=0.229
HapMap Asian Sub 246 G=0.801 A=0.199
HapMap Europe Sub 176 G=0.625 A=0.375
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 G=0.689 A=0.311
CNV burdens in cranial meningiomas Global Study-wide 774 G=0.907 A=0.093
CNV burdens in cranial meningiomas CRM Sub 774 G=0.907 A=0.093
Northern Sweden ACPOP Study-wide 600 G=0.708 A=0.292
SGDP_PRJ Global Study-wide 218 G=0.431 A=0.569
Qatari Global Study-wide 216 G=0.653 A=0.347
A Vietnamese Genetic Variation Database Global Study-wide 216 G=0.833 A=0.167
Ancient Sardinia genome-wide 1240k capture data generation and analysis Global Study-wide 42 G=0.48 A=0.52
Siberian Global Study-wide 26 G=0.46 A=0.54
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 22 NC_000022.11:g.19965038G>A
GRCh37.p13 chr 22 NC_000022.10:g.19952561G>A
COMT RefSeqGene (LRG_1010) NG_011526.1:g.28299G>A
Gene: COMT, catechol-O-methyltransferase (plus strand)
Molecule type Change Amino acid[Codon] SO Term
COMT transcript variant 1 NM_000754.4:c.615+739G>A N/A Intron Variant
COMT transcript variant 2 NM_001135161.2:c.615+739G…

NM_001135161.2:c.615+739G>A

N/A Intron Variant
COMT transcript variant 3 NM_001135162.2:c.615+739G…

NM_001135162.2:c.615+739G>A

N/A Intron Variant
COMT transcript variant 5 NM_001362828.2:c.615+739G…

NM_001362828.2:c.615+739G>A

N/A Intron Variant
COMT transcript variant 4 NM_007310.3:c.465+739G>A N/A Intron Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement G= A
GRCh38.p13 chr 22 NC_000022.11:g.19965038= NC_000022.11:g.19965038G>A
GRCh37.p13 chr 22 NC_000022.10:g.19952561= NC_000022.10:g.19952561G>A
COMT RefSeqGene (LRG_1010) NG_011526.1:g.28299= NG_011526.1:g.28299G>A
COMT transcript variant 1 NM_000754.3:c.615+739= NM_000754.3:c.615+739G>A
COMT transcript variant 1 NM_000754.4:c.615+739= NM_000754.4:c.615+739G>A
COMT transcript variant 2 NM_001135161.1:c.615+739= NM_001135161.1:c.615+739G>A
COMT transcript variant 2 NM_001135161.2:c.615+739= NM_001135161.2:c.615+739G>A
COMT transcript variant 3 NM_001135162.1:c.615+739= NM_001135162.1:c.615+739G>A
COMT transcript variant 3 NM_001135162.2:c.615+739= NM_001135162.2:c.615+739G>A
COMT transcript variant 5 NM_001362828.2:c.615+739= NM_001362828.2:c.615+739G>A
COMT transcript variant 4 NM_007310.2:c.465+739= NM_007310.2:c.465+739G>A
COMT transcript variant 4 NM_007310.3:c.465+739= NM_007310.3:c.465+739G>A
COMT transcript variant X1 XM_005261229.1:c.615+739= XM_005261229.1:c.615+739G>A
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

91 SubSNP, 20 Frequency submissions
No Submitter Submission ID Date (Build)
1 KWOK ss232571 Jul 12, 2000 (79)
2 SC ss459221 Jul 12, 2000 (79)
3 SC_JCM ss600392 Jul 16, 2000 (80)
4 KWOK ss1058123 Oct 04, 2000 (86)
5 KWOK ss1750409 Oct 18, 2000 (87)
6 RIKENSNPRC ss6311519 Feb 20, 2003 (111)
7 EGP_SNPS ss12673771 Dec 05, 2003 (119)
8 ABI ss44321560 Mar 14, 2006 (126)
9 ILLUMINA ss66673340 Nov 29, 2006 (127)
10 EGP_SNPS ss66862093 Nov 29, 2006 (127)
11 ILLUMINA ss67144916 Nov 29, 2006 (127)
12 ILLUMINA ss67486513 Nov 29, 2006 (127)
13 ILLUMINA ss70447451 May 16, 2007 (127)
14 ILLUMINA ss70638431 May 25, 2008 (130)
15 ILLUMINA ss71189405 May 16, 2007 (127)
16 ILLUMINA ss75601015 Dec 06, 2007 (129)
17 KRIBB_YJKIM ss83374081 Dec 15, 2007 (130)
18 BCMHGSC_JDW ss91877555 Mar 24, 2008 (129)
19 1000GENOMES ss112551496 Jan 25, 2009 (130)
20 1000GENOMES ss114036073 Jan 25, 2009 (130)
21 ILLUMINA-UK ss117362081 Feb 14, 2009 (130)
22 ILLUMINA ss121771595 Dec 01, 2009 (131)
23 ENSEMBL ss138335203 Dec 01, 2009 (131)
24 ILLUMINA ss153545863 Dec 01, 2009 (131)
25 ILLUMINA ss159291067 Dec 01, 2009 (131)
26 ILLUMINA ss160381553 Dec 01, 2009 (131)
27 COMPLETE_GENOMICS ss168891673 Jul 04, 2010 (132)
28 ILLUMINA ss170702259 Jul 04, 2010 (132)
29 COMPLETE_GENOMICS ss171832785 Jul 04, 2010 (132)
30 ILLUMINA ss172611436 Jul 04, 2010 (132)
31 BUSHMAN ss204050457 Jul 04, 2010 (132)
32 1000GENOMES ss228618153 Jul 14, 2010 (132)
33 1000GENOMES ss238022310 Jul 15, 2010 (132)
34 1000GENOMES ss244151670 Jul 15, 2010 (132)
35 GMI ss287550249 Apr 25, 2013 (138)
36 ILLUMINA ss479842714 May 04, 2012 (137)
37 ILLUMINA ss480743447 Sep 08, 2015 (146)
38 ILLUMINA ss484289290 May 04, 2012 (137)
39 TISHKOFF ss566560797 Apr 25, 2013 (138)
40 SSMP ss662483759 Apr 25, 2013 (138)
41 ILLUMINA ss781082318 Sep 08, 2015 (146)
42 ILLUMINA ss825416184 Jul 19, 2016 (147)
43 ILLUMINA ss832803178 Jul 13, 2019 (153)
44 EVA-GONL ss995222810 Aug 21, 2014 (142)
45 JMKIDD_LAB ss1082570475 Aug 21, 2014 (142)
46 1000GENOMES ss1366683163 Aug 21, 2014 (142)
47 DDI ss1429219791 Apr 01, 2015 (144)
48 EVA_UK10K_ALSPAC ss1639753971 Apr 01, 2015 (144)
49 EVA_UK10K_TWINSUK ss1682748004 Apr 01, 2015 (144)
50 EVA_DECODE ss1699291916 Apr 01, 2015 (144)
51 EVA_SVP ss1713731250 Apr 01, 2015 (144)
52 WEILL_CORNELL_DGM ss1938784410 Feb 12, 2016 (147)
53 GENOMED ss1969246881 Jul 19, 2016 (147)
54 JJLAB ss2030165222 Sep 14, 2016 (149)
55 USC_VALOUEV ss2158775178 Dec 20, 2016 (150)
56 HUMAN_LONGEVITY ss2246457103 Dec 20, 2016 (150)
57 TOPMED ss2413284001 Dec 20, 2016 (150)
58 SYSTEMSBIOZJU ss2629580763 Nov 08, 2017 (151)
59 GRF ss2704518133 Nov 08, 2017 (151)
60 ILLUMINA ss2710952875 Nov 08, 2017 (151)
61 GNOMAD ss2972986409 Nov 08, 2017 (151)
62 AFFY ss2985850724 Nov 08, 2017 (151)
63 SWEGEN ss3019086385 Nov 08, 2017 (151)
64 BIOINF_KMB_FNS_UNIBA ss3028920327 Nov 08, 2017 (151)
65 CSHL ss3352776500 Nov 08, 2017 (151)
66 TOPMED ss3374061385 Nov 08, 2017 (151)
67 ILLUMINA ss3636556588 Oct 12, 2018 (152)
68 ILLUMINA ss3638374448 Oct 12, 2018 (152)
69 ILLUMINA ss3639191047 Oct 12, 2018 (152)
70 ILLUMINA ss3639611683 Oct 12, 2018 (152)
71 ILLUMINA ss3643334856 Oct 12, 2018 (152)
72 EGCUT_WGS ss3685618896 Jul 13, 2019 (153)
73 EVA_DECODE ss3707954978 Jul 13, 2019 (153)
74 ACPOP ss3743823291 Jul 13, 2019 (153)
75 EVA ss3759230944 Jul 13, 2019 (153)
76 PACBIO ss3788793365 Jul 13, 2019 (153)
77 PACBIO ss3793664456 Jul 13, 2019 (153)
78 PACBIO ss3798550781 Jul 13, 2019 (153)
79 KHV_HUMAN_GENOMES ss3822398829 Jul 13, 2019 (153)
80 EVA ss3825965522 Apr 27, 2020 (154)
81 EVA ss3835927810 Apr 27, 2020 (154)
82 HGDP ss3847684688 Apr 27, 2020 (154)
83 SGDP_PRJ ss3890256828 Apr 27, 2020 (154)
84 KRGDB ss3940640413 Apr 27, 2020 (154)
85 KOGIC ss3983389688 Apr 27, 2020 (154)
86 EVA ss3984758332 Apr 26, 2021 (155)
87 EVA ss3985910181 Apr 26, 2021 (155)
88 EVA ss4017873658 Apr 26, 2021 (155)
89 TOPMED ss5105108405 Apr 26, 2021 (155)
90 TOMMO_GENOMICS ss5232040612 Apr 26, 2021 (155)
91 EVA ss5237615149 Apr 26, 2021 (155)
92 1000Genomes NC_000022.10 - 19952561 Oct 12, 2018 (152)
93 The Avon Longitudinal Study of Parents and Children NC_000022.10 - 19952561 Oct 12, 2018 (152)
94 Genetic variation in the Estonian population NC_000022.10 - 19952561 Oct 12, 2018 (152)
95 gnomAD - Genomes NC_000022.11 - 19965038 Apr 26, 2021 (155)
96 Genome of the Netherlands Release 5 NC_000022.10 - 19952561 Apr 27, 2020 (154)
97 HGDP-CEPH-db Supplement 1 NC_000022.9 - 18332561 Apr 27, 2020 (154)
98 HapMap NC_000022.11 - 19965038 Apr 27, 2020 (154)
99 KOREAN population from KRGDB NC_000022.10 - 19952561 Apr 27, 2020 (154)
100 Korean Genome Project NC_000022.11 - 19965038 Apr 27, 2020 (154)
101 Northern Sweden NC_000022.10 - 19952561 Jul 13, 2019 (153)
102 Ancient Sardinia genome-wide 1240k capture data generation and analysis NC_000022.10 - 19952561 Apr 26, 2021 (155)
103 CNV burdens in cranial meningiomas NC_000022.10 - 19952561 Apr 26, 2021 (155)
104 Qatari NC_000022.10 - 19952561 Apr 27, 2020 (154)
105 SGDP_PRJ NC_000022.10 - 19952561 Apr 27, 2020 (154)
106 Siberian NC_000022.10 - 19952561 Apr 27, 2020 (154)
107 8.3KJPN NC_000022.10 - 19952561 Apr 26, 2021 (155)
108 TopMed NC_000022.11 - 19965038 Apr 26, 2021 (155)
109 UK 10K study - Twins NC_000022.10 - 19952561 Oct 12, 2018 (152)
110 A Vietnamese Genetic Variation Database NC_000022.10 - 19952561 Jul 13, 2019 (153)
111 ALFA NC_000022.11 - 19965038 Apr 26, 2021 (155)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs59344350 May 25, 2008 (130)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss3639191047, ss3639611683 NC_000022.8:18327114:G:A NC_000022.11:19965037:G:A (self)
362580, ss91877555, ss112551496, ss114036073, ss117362081, ss168891673, ss171832785, ss204050457, ss287550249, ss484289290, ss825416184, ss1699291916, ss1713731250, ss3643334856, ss3847684688 NC_000022.9:18332560:G:A NC_000022.11:19965037:G:A (self)
80217594, 44382042, 31357144, 19773919, 47817807, 17108156, 1136108, 307913, 20826332, 42273808, 11291532, 90009919, 44382042, 9792547, ss228618153, ss238022310, ss244151670, ss479842714, ss480743447, ss566560797, ss662483759, ss781082318, ss832803178, ss995222810, ss1082570475, ss1366683163, ss1429219791, ss1639753971, ss1682748004, ss1938784410, ss1969246881, ss2030165222, ss2158775178, ss2413284001, ss2629580763, ss2704518133, ss2710952875, ss2972986409, ss2985850724, ss3019086385, ss3352776500, ss3636556588, ss3638374448, ss3685618896, ss3743823291, ss3759230944, ss3788793365, ss3793664456, ss3798550781, ss3825965522, ss3835927810, ss3890256828, ss3940640413, ss3984758332, ss3985910181, ss4017873658, ss5232040612, ss5237615149 NC_000022.10:19952560:G:A NC_000022.11:19965037:G:A (self)
566544169, 2227949, 39767689, 237443688, 380217352, 10972150040, ss2246457103, ss3028920327, ss3374061385, ss3707954978, ss3822398829, ss3983389688, ss5105108405 NC_000022.11:19965037:G:A NC_000022.11:19965037:G:A (self)
ss232571, ss459221, ss600392, ss1058123, ss1750409, ss6311519, ss12673771, ss44321560, ss66673340, ss66862093, ss67144916, ss67486513, ss70447451, ss70638431, ss71189405, ss75601015, ss83374081, ss121771595, ss138335203, ss153545863, ss159291067, ss160381553, ss170702259, ss172611436 NT_011519.10:3104710:G:A NC_000022.11:19965037:G:A (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

20 citations for rs165774
PMID Title Author Year Journal
17442488 An association study between cathechol-O-methyltransferase gene and mental retardation in the Chinese Han population. Zhang K et al. 2007 Neuroscience letters
18436194 Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Hettema JM et al. 2008 Biological psychiatry
18937309 Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study. Biederman J et al. 2008 American journal of medical genetics. Part B, Neuropsychiatric genetics
19673036 Association of tagging single nucleotide polymorphisms on 8 candidate genes in dopaminergic pathway with schizophrenia in Croatian population. Pal P et al. 2009 Croatian medical journal
20083391 A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry. Strohmaier J et al. 2010 Schizophrenia research
20551675 Localizing putative markers in genetic association studies by incorporating linkage disequilibrium into bayesian hierarchical models. Fridley BL et al. 2010 Human heredity
20877297 Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response. Ji Y et al. 2012 The pharmacogenomics journal
20934310 HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association. Voisey J et al. 2012 European psychiatry
21172166 Pharmacogenetics of antidepressant response. Porcelli S et al. 2011 Journal of psychiatry & neuroscience
22021758 Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort. Nyman ES et al. 2011 BMJ open
23963787 Complex multilocus effects of catechol-O-methyltransferase haplotypes predict pain and pain interference 6 weeks after motor vehicle collision. Bortsov AV et al. 2014 Neuromolecular medicine
25073638 Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis. Andreou D et al. 2014 Behavioral and brain functions
26207649 COMT gene locus: new functional variants. Meloto CB et al. 2015 Pain
26852906 Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia. Higashiyama R et al. 2016 American journal of medical genetics. Part B, Neuropsychiatric genetics
27347613 Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study. Seib C et al. 2016 Genetic testing and molecular biomarkers
27521242 TPH-2 Polymorphisms Interact with Early Life Stress to Influence Response to Treatment with Antidepressant Drugs. Xu Z et al. 2016 The international journal of neuropsychopharmacology
29255361 Potential link between genetic polymorphisms of <i>catechol-O-methyltransferase</i> and dopamine receptors and treatment efficacy of risperidone on schizophrenia. Han J et al. 2017 Neuropsychiatric disease and treatment
29550002 Pulp Sensitivity: Influence of Sex, Psychosocial Variables, COMT Gene, and Chronic Facial Pain. Mladenovic I et al. 2018 Journal of endodontics
31085105 Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management. Yang GS et al. 2019 Seminars in oncology nursing
31285095 Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients. de Souza Tesch R et al. 2020 International journal of oral and maxillofacial surgery
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The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post676+237644a