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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs1045642

Current Build 155

Released April 9, 2021

Organism
Homo sapiens
Position
chr7:87509329 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
A>C / A>G / A>T
Variation Type
SNV Single Nucleotide Variation
Frequency
G=0.493167 (166518/337650, ALFA)
A=0.400892 (106112/264690, TOPMED)
A=0.495703 (124576/251312, GnomAD_exome) (+ 24 more)
A=0.421039 (58921/139942, GnomAD)
A=0.496564 (60266/121366, ExAC)
A=0.33413 (26296/78700, PAGE_STUDY)
A=0.41753 (6997/16758, 8.3KJPN)
A=0.42334 (5506/13006, GO-ESP)
A=0.3952 (1979/5008, 1000G)
G=0.4681 (2097/4480, Estonian)
G=0.4668 (1799/3854, ALSPAC)
G=0.4614 (1711/3708, TWINSUK)
A=0.3488 (1022/2930, KOREAN)
A=0.3996 (732/1832, Korea1K)
A=0.3643 (620/1702, HapMap)
G=0.4137 (470/1136, Daghestan)
G=0.487 (486/998, GoNL)
A=0.385 (305/792, PRJEB37584)
A=0.337 (206/612, Vietnamese)
G=0.412 (247/600, NorthernSweden)
A=0.440 (235/534, MGP)
A=0.302 (130/430, SGDP_PRJ)
G=0.444 (135/304, FINRISK)
A=0.463 (100/216, Qatari)
A=0.50 (20/40, GENOME_DK)
G=0.50 (20/40, GENOME_DK)
A=0.34 (13/38, Siberian)
Clinical Significance
Reported in ClinVar
Gene : Consequence
ABCB1 : Missense Variant
Publications
561 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 7 NC_000007.14:g.87509329A>C
GRCh38.p13 chr 7 NC_000007.14:g.87509329A>G
GRCh38.p13 chr 7 NC_000007.14:g.87509329A>T
GRCh37.p13 chr 7 NC_000007.13:g.87138645A>C
GRCh37.p13 chr 7 NC_000007.13:g.87138645A>G
GRCh37.p13 chr 7 NC_000007.13:g.87138645A>T
ABCB1 RefSeqGene NG_011513.1:g.208920T>G
ABCB1 RefSeqGene NG_011513.1:g.208920T>C
ABCB1 RefSeqGene NG_011513.1:g.208920T>A
Gene: ABCB1, ATP binding cassette subfamily B member 1 (minus strand)
Molecule type Change Amino acid[Codon] SO Term
ABCB1 transcript variant 4 NM_001348946.2:c.3435T>G I [ATT] > M [ATG] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 2 NP_001335875.1:p.Ile1145M…

NP_001335875.1:p.Ile1145Met

I (Ile) > M (Met) Missense Variant
ABCB1 transcript variant 4 NM_001348946.2:c.3435T>C I [ATT] > I [ATC] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 2 NP_001335875.1:p.Ile1145= I (Ile) > I (Ile) Synonymous Variant
ABCB1 transcript variant 4 NM_001348946.2:c.3435T>A I [ATT] > I [ATA] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 2 NP_001335875.1:p.Ile1145= I (Ile) > I (Ile) Synonymous Variant
ABCB1 transcript variant 2 NM_001348944.2:c.3435T>G I [ATT] > M [ATG] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 2 NP_001335873.1:p.Ile1145M…

NP_001335873.1:p.Ile1145Met

I (Ile) > M (Met) Missense Variant
ABCB1 transcript variant 2 NM_001348944.2:c.3435T>C I [ATT] > I [ATC] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 2 NP_001335873.1:p.Ile1145= I (Ile) > I (Ile) Synonymous Variant
ABCB1 transcript variant 2 NM_001348944.2:c.3435T>A I [ATT] > I [ATA] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 2 NP_001335873.1:p.Ile1145= I (Ile) > I (Ile) Synonymous Variant
ABCB1 transcript variant 3 NM_000927.5:c.3435T>G I [ATT] > M [ATG] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 2 NP_000918.2:p.Ile1145Met I (Ile) > M (Met) Missense Variant
ABCB1 transcript variant 3 NM_000927.5:c.3435T>C I [ATT] > I [ATC] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 2 NP_000918.2:p.Ile1145= I (Ile) > I (Ile) Synonymous Variant
ABCB1 transcript variant 3 NM_000927.5:c.3435T>A I [ATT] > I [ATA] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 2 NP_000918.2:p.Ile1145= I (Ile) > I (Ile) Synonymous Variant
ABCB1 transcript variant 1 NM_001348945.2:c.3645T>G I [ATT] > M [ATG] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 1 NP_001335874.1:p.Ile1215M…

NP_001335874.1:p.Ile1215Met

I (Ile) > M (Met) Missense Variant
ABCB1 transcript variant 1 NM_001348945.2:c.3645T>C I [ATT] > I [ATC] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 1 NP_001335874.1:p.Ile1215= I (Ile) > I (Ile) Synonymous Variant
ABCB1 transcript variant 1 NM_001348945.2:c.3645T>A I [ATT] > I [ATA] Coding Sequence Variant
ATP-dependent translocase ABCB1 isoform 1 NP_001335874.1:p.Ile1215= I (Ile) > I (Ile) Synonymous Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: A= (allele ID: 502132 )
ClinVar Accession Disease Names Clinical Significance
RCV000602614.1 not specified Benign
Allele: G (allele ID: 227763 )
ClinVar Accession Disease Names Clinical Significance
RCV000014699.2 MDR1 POLYMORPHISM Benign
RCV000211142.1 ondansetron response - Efficacy Drug-Response
RCV000211266.1 methotrexate response - Toxicity/ADR Drug-Response
RCV000211276.1 nevirapine response - Toxicity/ADR Drug-Response
RCV000211363.1 digoxin response - Other Drug-Response
RCV000441548.1 Non-small cell lung cancer Not-Provided
RCV000660758.1 fentanyl response - Dosage, Efficacy Drug-Response
RCV000660759.1 methadone response - Dosage, Efficacy Drug-Response
RCV000660760.1 morphine response - Dosage, Efficacy Drug-Response
RCV000660761.1 opioids response - Dosage, Efficacy Drug-Response
RCV000660762.1 oxycodone response - Dosage, Efficacy Drug-Response
RCV000660763.1 tramadol response - Dosage, Efficacy Drug-Response
RCV000835732.1 not provided Benign
RCV001029504.1 Tramadol response Drug-Response

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 337650 A=0.506833 G=0.493167
European Sub 293140 A=0.519499 G=0.480501
African Sub 9250 A=0.2215 G=0.7785
African Others Sub 338 A=0.124 G=0.876
African American Sub 8912 A=0.2252 G=0.7748
Asian Sub 3960 A=0.3826 G=0.6174
East Asian Sub 3152 A=0.3769 G=0.6231
Other Asian Sub 808 A=0.405 G=0.595
Latin American 1 Sub 1594 A=0.4210 G=0.5790
Latin American 2 Sub 8502 A=0.4520 G=0.5480
South Asian Sub 5230 A=0.6126 G=0.3874
Other Sub 15974 A=0.47352 G=0.52648


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 A=0.400892 G=0.599108
gnomAD - Exomes Global Study-wide 251312 A=0.495703 G=0.504297
gnomAD - Exomes European Sub 135256 A=0.546201 G=0.453799
gnomAD - Exomes Asian Sub 48998 A=0.51590 G=0.48410
gnomAD - Exomes American Sub 34588 A=0.45186 G=0.54814
gnomAD - Exomes African Sub 16256 A=0.19820 G=0.80180
gnomAD - Exomes Ashkenazi Jewish Sub 10078 A=0.35632 G=0.64368
gnomAD - Exomes Other Sub 6136 A=0.4855 G=0.5145
gnomAD - Genomes Global Study-wide 139942 A=0.421039 G=0.578961
gnomAD - Genomes European Sub 75798 A=0.54356 G=0.45644
gnomAD - Genomes African Sub 41916 A=0.20505 G=0.79495
gnomAD - Genomes American Sub 13628 A=0.43557 G=0.56443
gnomAD - Genomes Ashkenazi Jewish Sub 3322 A=0.3465 G=0.6535
gnomAD - Genomes East Asian Sub 3126 A=0.3733 G=0.6267
gnomAD - Genomes Other Sub 2152 A=0.4047 G=0.5953
ExAC Global Study-wide 121366 A=0.496564 G=0.503436
ExAC Europe Sub 73340 A=0.53553 G=0.46447
ExAC Asian Sub 25144 A=0.52418 G=0.47582
ExAC American Sub 11568 A=0.45332 G=0.54668
ExAC African Sub 10406 A=0.20200 G=0.79800
ExAC Other Sub 908 A=0.511 G=0.489
The PAGE Study Global Study-wide 78700 A=0.33413 G=0.66587
The PAGE Study AfricanAmerican Sub 32516 A=0.21386 G=0.78614
The PAGE Study Mexican Sub 10810 A=0.44820 G=0.55180
The PAGE Study Asian Sub 8316 A=0.4031 G=0.5969
The PAGE Study PuertoRican Sub 7918 A=0.3846 G=0.6154
The PAGE Study NativeHawaiian Sub 4534 A=0.4356 G=0.5644
The PAGE Study Cuban Sub 4230 A=0.4095 G=0.5905
The PAGE Study Dominican Sub 3828 A=0.3378 G=0.6622
The PAGE Study CentralAmerican Sub 2450 A=0.4531 G=0.5469
The PAGE Study SouthAmerican Sub 1982 A=0.4506 G=0.5494
The PAGE Study NativeAmerican Sub 1260 A=0.4571 G=0.5429
The PAGE Study SouthAsian Sub 856 A=0.609 G=0.391
8.3KJPN JAPANESE Study-wide 16758 A=0.41753 G=0.58247
GO Exome Sequencing Project Global Study-wide 13006 A=0.42334 G=0.57666
GO Exome Sequencing Project European American Sub 8600 A=0.5236 G=0.4764
GO Exome Sequencing Project African American Sub 4406 A=0.2276 G=0.7724
1000Genomes Global Study-wide 5008 A=0.3952 G=0.6048
1000Genomes African Sub 1322 A=0.1498 G=0.8502
1000Genomes East Asian Sub 1008 A=0.3978 G=0.6022
1000Genomes Europe Sub 1006 A=0.5179 G=0.4821
1000Genomes South Asian Sub 978 A=0.575 G=0.425
1000Genomes American Sub 694 A=0.428 G=0.572
Genetic variation in the Estonian population Estonian Study-wide 4480 A=0.5319 G=0.4681
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 A=0.5332 G=0.4668
UK 10K study - Twins TWIN COHORT Study-wide 3708 A=0.5386 G=0.4614
KOREAN population from KRGDB KOREAN Study-wide 2930 A=0.3488 C=0.0000, G=0.6512
Korean Genome Project KOREAN Study-wide 1832 A=0.3996 G=0.6004
HapMap Global Study-wide 1702 A=0.3643 G=0.6357
HapMap American Sub 766 A=0.470 G=0.530
HapMap African Sub 508 A=0.134 G=0.866
HapMap Asian Sub 252 A=0.437 G=0.563
HapMap Europe Sub 176 A=0.466 G=0.534
Genome-wide autozygosity in Daghestan Global Study-wide 1136 A=0.5863 G=0.4137
Genome-wide autozygosity in Daghestan Daghestan Sub 628 A=0.642 G=0.358
Genome-wide autozygosity in Daghestan Near_East Sub 144 A=0.549 G=0.451
Genome-wide autozygosity in Daghestan Central Asia Sub 122 A=0.459 G=0.541
Genome-wide autozygosity in Daghestan Europe Sub 108 A=0.519 G=0.481
Genome-wide autozygosity in Daghestan South Asian Sub 98 A=0.61 G=0.39
Genome-wide autozygosity in Daghestan Caucasus Sub 36 A=0.33 G=0.67
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 A=0.513 G=0.487
CNV burdens in cranial meningiomas Global Study-wide 792 A=0.385 G=0.615
CNV burdens in cranial meningiomas CRM Sub 792 A=0.385 G=0.615
A Vietnamese Genetic Variation Database Global Study-wide 612 A=0.337 G=0.663
Northern Sweden ACPOP Study-wide 600 A=0.588 G=0.412
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 A=0.440 G=0.560
SGDP_PRJ Global Study-wide 430 A=0.302 G=0.698
FINRISK Finnish from FINRISK project Study-wide 304 A=0.556 G=0.444
Qatari Global Study-wide 216 A=0.463 G=0.537
The Danish reference pan genome Danish Study-wide 40 A=0.50 G=0.50
Siberian Global Study-wide 38 A=0.34 G=0.66
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement A= C G T
GRCh38.p13 chr 7 NC_000007.14:g.87509329= NC_000007.14:g.87509329A>C NC_000007.14:g.87509329A>G NC_000007.14:g.87509329A>T
GRCh37.p13 chr 7 NC_000007.13:g.87138645= NC_000007.13:g.87138645A>C NC_000007.13:g.87138645A>G NC_000007.13:g.87138645A>T
ABCB1 RefSeqGene NG_011513.1:g.208920= NG_011513.1:g.208920T>G NG_011513.1:g.208920T>C NG_011513.1:g.208920T>A
ABCB1 transcript variant 3 NM_000927.5:c.3435= NM_000927.5:c.3435T>G NM_000927.5:c.3435T>C NM_000927.5:c.3435T>A
ABCB1 transcript variant 3 NM_000927.4:c.3435= NM_000927.4:c.3435T>G NM_000927.4:c.3435T>C NM_000927.4:c.3435T>A
ABCB1 transcript variant 1 NM_001348945.2:c.3645= NM_001348945.2:c.3645T>G NM_001348945.2:c.3645T>C NM_001348945.2:c.3645T>A
ABCB1 transcript variant 1 NM_001348945.1:c.3645= NM_001348945.1:c.3645T>G NM_001348945.1:c.3645T>C NM_001348945.1:c.3645T>A
ABCB1 transcript variant 2 NM_001348944.2:c.3435= NM_001348944.2:c.3435T>G NM_001348944.2:c.3435T>C NM_001348944.2:c.3435T>A
ABCB1 transcript variant 2 NM_001348944.1:c.3435= NM_001348944.1:c.3435T>G NM_001348944.1:c.3435T>C NM_001348944.1:c.3435T>A
ABCB1 transcript variant 4 NM_001348946.2:c.3435= NM_001348946.2:c.3435T>G NM_001348946.2:c.3435T>C NM_001348946.2:c.3435T>A
ABCB1 transcript variant 4 NM_001348946.1:c.3435= NM_001348946.1:c.3435T>G NM_001348946.1:c.3435T>C NM_001348946.1:c.3435T>A
ATP-dependent translocase ABCB1 isoform 2 NP_000918.2:p.Ile1145= NP_000918.2:p.Ile1145Met NP_000918.2:p.Ile1145= NP_000918.2:p.Ile1145=
ATP-dependent translocase ABCB1 isoform 1 NP_001335874.1:p.Ile1215= NP_001335874.1:p.Ile1215Met NP_001335874.1:p.Ile1215= NP_001335874.1:p.Ile1215=
ATP-dependent translocase ABCB1 isoform 2 NP_001335873.1:p.Ile1145= NP_001335873.1:p.Ile1145Met NP_001335873.1:p.Ile1145= NP_001335873.1:p.Ile1145=
ATP-dependent translocase ABCB1 isoform 2 NP_001335875.1:p.Ile1145= NP_001335875.1:p.Ile1145Met NP_001335875.1:p.Ile1145= NP_001335875.1:p.Ile1145=
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

166 SubSNP, 26 Frequency, 15 ClinVar submissions
No Submitter Submission ID Date (Build)
1 LEE ss1516019 Oct 05, 2000 (86)
2 OEFNER ss3189038 Aug 15, 2001 (98)
3 YUSUKE ss3226651 Sep 28, 2001 (100)
4 RIKENSNPRC ss5602934 Dec 12, 2002 (110)
5 WI_SSAHASNP ss11850648 Jul 11, 2003 (116)
6 WI_SSAHASNP ss13491476 Dec 05, 2003 (120)
7 WUGSC_SSAHASNP ss14109462 Dec 05, 2003 (120)
8 PERLEGEN ss24420709 Sep 20, 2004 (123)
9 EGP_SNPS ss35072275 May 24, 2005 (125)
10 SSAHASNP ss35092270 May 24, 2005 (125)
11 SNP500CANCER ss48292336 Mar 13, 2006 (126)
12 ILLUMINA ss65736313 Oct 16, 2006 (127)
13 AFFY ss66452652 Dec 01, 2006 (127)
14 PERLEGEN ss69021329 May 17, 2007 (127)
15 PHARMGKB_PMT ss69365429 May 17, 2007 (127)
16 PHARMGKB_PMT ss69365430 May 17, 2007 (127)
17 PHARMGKB_PAAR-SJCRH ss69365642 May 17, 2007 (127)
18 PHARMGKB_PAAR-SJCRH ss69366457 May 17, 2007 (127)
19 PHARMGKB_COBRA ss69366472 May 17, 2007 (127)
20 PHARMGKB_CREATE ss69366742 May 17, 2007 (127)
21 PHARMGKB_PMT ss69369686 May 17, 2007 (127)
22 PHARMGKB_CREATE ss69369753 May 17, 2007 (127)
23 PHARMGKB_PAAR-SJCRH ss69369879 May 17, 2007 (127)
24 ILLUMINA ss74872185 Dec 07, 2007 (129)
25 AFFY ss76244224 Dec 08, 2007 (129)
26 AFFY_GWHS ss77104356 Dec 07, 2007 (129)
27 CCHMC-CAE-PGCORE ss79313675 Dec 15, 2007 (130)
28 PHARMGKB_CREATE ss84172890 Dec 15, 2007 (130)
29 PHARMGKB_CREATE ss84172932 Dec 15, 2007 (130)
30 PHARMGKB_CREATE ss84172983 Dec 15, 2007 (130)
31 HGSV ss84662917 Dec 15, 2007 (130)
32 CORNELL ss86271714 Mar 23, 2008 (129)
33 HUMANGENOME_JCVI ss98315192 Feb 05, 2009 (130)
34 BGI ss104448230 Dec 01, 2009 (131)
35 PHARMGKB_PAAR-UCHI ss105107793 Feb 05, 2009 (130)
36 PHARMGKB_PAAR-UCHI ss105109711 Feb 05, 2009 (130)
37 PHARMGKB_PAAR-UCHI ss105109973 Feb 05, 2009 (130)
38 1000GENOMES ss112311473 Jan 25, 2009 (130)
39 1000GENOMES ss114052258 Jan 25, 2009 (130)
40 ILLUMINA-UK ss116181203 Feb 14, 2009 (130)
41 KRIBB_YJKIM ss119379841 Dec 01, 2009 (131)
42 ENSEMBL ss143599552 Dec 01, 2009 (131)
43 ILLUMINA ss152729403 Dec 01, 2009 (131)
44 GMI ss155153917 Dec 01, 2009 (131)
45 ILLUMINA ss159124265 Dec 01, 2009 (131)
46 SEATTLESEQ ss159715056 Dec 01, 2009 (131)
47 ILLUMINA ss159895285 Dec 01, 2009 (131)
48 PHARMGKB_PAAR-UCHI ss160865039 Dec 01, 2009 (131)
49 PHARMGKB_PAAR-UCHI ss160865216 Dec 01, 2009 (131)
50 COMPLETE_GENOMICS ss162505427 Jul 04, 2010 (132)
51 COMPLETE_GENOMICS ss164774216 Jul 04, 2010 (132)
52 ILLUMINA ss170100088 Jul 04, 2010 (132)
53 AFFY ss172950537 Jul 04, 2010 (132)
54 BUSHMAN ss203606929 Jul 04, 2010 (132)
55 1000GENOMES ss223187915 Jul 14, 2010 (132)
56 1000GENOMES ss234063912 Jul 15, 2010 (132)
57 1000GENOMES ss241001912 Jul 15, 2010 (132)
58 ILLUMINA ss244268994 Jul 04, 2010 (132)
59 GMI ss279425977 May 04, 2012 (137)
60 PJP ss293910902 May 09, 2011 (134)
61 NHLBI-ESP ss342238477 May 09, 2011 (134)
62 ILLUMINA ss479271043 May 04, 2012 (137)
63 ILLUMINA ss479273892 May 04, 2012 (137)
64 ILLUMINA ss479646961 Sep 08, 2015 (146)
65 ILLUMINA ss484436125 May 04, 2012 (137)
66 1000GENOMES ss490948047 May 04, 2012 (137)
67 GSK-GENETICS ss491275584 May 04, 2012 (137)
68 EXOME_CHIP ss491401201 May 04, 2012 (137)
69 CLINSEQ_SNP ss491909106 May 04, 2012 (137)
70 ILLUMINA ss536606462 Sep 08, 2015 (146)
71 TISHKOFF ss560134735 Apr 25, 2013 (138)
72 SSMP ss654533775 Apr 25, 2013 (138)
73 ILLUMINA ss778356341 Sep 08, 2015 (146)
74 ILLUMINA ss782664531 Sep 08, 2015 (146)
75 ILLUMINA ss783633368 Sep 08, 2015 (146)
76 ILLUMINA ss831915095 Sep 08, 2015 (146)
77 ILLUMINA ss832636978 Jul 13, 2019 (153)
78 ILLUMINA ss833811086 Sep 08, 2015 (146)
79 JMKIDD_LAB ss974464787 Aug 21, 2014 (142)
80 EVA-GONL ss984506888 Aug 21, 2014 (142)
81 JMKIDD_LAB ss1067489400 Aug 21, 2014 (142)
82 JMKIDD_LAB ss1074771513 Aug 21, 2014 (142)
83 1000GENOMES ss1326013973 Aug 21, 2014 (142)
84 HAMMER_LAB ss1397499383 Sep 08, 2015 (146)
85 DDI ss1431200590 Apr 01, 2015 (144)
86 EVA_GENOME_DK ss1582294088 Apr 01, 2015 (144)
87 EVA_FINRISK ss1584053260 Apr 01, 2015 (144)
88 EVA_DECODE ss1594082757 Apr 01, 2015 (144)
89 EVA_UK10K_ALSPAC ss1618630416 Apr 01, 2015 (144)
90 EVA_UK10K_TWINSUK ss1661624449 Apr 01, 2015 (144)
91 EVA_EXAC ss1688802986 Apr 01, 2015 (144)
92 EVA_MGP ss1711170584 Apr 01, 2015 (144)
93 EVA_SVP ss1712968766 Apr 01, 2015 (144)
94 ILLUMINA ss1752698099 Sep 08, 2015 (146)
95 HAMMER_LAB ss1805098504 Sep 08, 2015 (146)
96 WEILL_CORNELL_DGM ss1927770035 Feb 12, 2016 (147)
97 ILLUMINA ss1946213129 Feb 12, 2016 (147)
98 ILLUMINA ss1959029210 Feb 12, 2016 (147)
99 GENOMED ss1970753045 Jul 19, 2016 (147)
100 JJLAB ss2024567436 Sep 14, 2016 (149)
101 USC_VALOUEV ss2152788121 Dec 20, 2016 (150)
102 HUMAN_LONGEVITY ss2295530964 Dec 20, 2016 (150)
103 TOPMED ss2464894451 Dec 20, 2016 (150)
104 SYSTEMSBIOZJU ss2626775179 Nov 08, 2017 (151)
105 ILLUMINA ss2634628850 Nov 08, 2017 (151)
106 ILLUMINA ss2634628851 Nov 08, 2017 (151)
107 ILLUMINA ss2635174036 Nov 08, 2017 (151)
108 GRF ss2708492793 Nov 08, 2017 (151)
109 ILLUMINA ss2710663301 Nov 08, 2017 (151)
110 GNOMAD ss2736538737 Nov 08, 2017 (151)
111 GNOMAD ss2747854033 Nov 08, 2017 (151)
112 GNOMAD ss2855815012 Nov 08, 2017 (151)
113 AFFY ss2985411524 Nov 08, 2017 (151)
114 AFFY ss2986042871 Nov 08, 2017 (151)
115 SWEGEN ss3001577507 Nov 08, 2017 (151)
116 EVA_SAMSUNG_MC ss3023063080 Nov 08, 2017 (151)
117 BIOINF_KMB_FNS_UNIBA ss3026077180 Nov 08, 2017 (151)
118 CSIRBIOHTS ss3029637883 Nov 08, 2017 (151)
119 CSHL ss3347717361 Nov 08, 2017 (151)
120 TOPMED ss3536823730 Nov 08, 2017 (151)
121 ILLUMINA ss3625932195 Oct 12, 2018 (152)
122 ILLUMINA ss3629856411 Oct 12, 2018 (152)
123 ILLUMINA ss3632535049 Oct 12, 2018 (152)
124 ILLUMINA ss3633469219 Oct 12, 2018 (152)
125 ILLUMINA ss3634194450 Oct 12, 2018 (152)
126 ILLUMINA ss3635128944 Oct 12, 2018 (152)
127 ILLUMINA ss3635874113 Oct 12, 2018 (152)
128 ILLUMINA ss3636862402 Oct 12, 2018 (152)
129 ILLUMINA ss3637627104 Oct 12, 2018 (152)
130 ILLUMINA ss3638708191 Oct 12, 2018 (152)
131 ILLUMINA ss3640836236 Oct 12, 2018 (152)
132 ILLUMINA ss3643643278 Oct 12, 2018 (152)
133 ILLUMINA ss3644946230 Oct 12, 2018 (152)
134 OMUKHERJEE_ADBS ss3646358864 Oct 12, 2018 (152)
135 URBANLAB ss3648694776 Oct 12, 2018 (152)
136 ILLUMINA ss3654172888 Oct 12, 2018 (152)
137 EGCUT_WGS ss3669331006 Jul 13, 2019 (153)
138 EVA_DECODE ss3720146019 Jul 13, 2019 (153)
139 ACPOP ss3734834333 Jul 13, 2019 (153)
140 ILLUMINA ss3744292469 Jul 13, 2019 (153)
141 ILLUMINA ss3745428961 Jul 13, 2019 (153)
142 EVA ss3766828464 Jul 13, 2019 (153)
143 PAGE_CC ss3771381313 Jul 13, 2019 (153)
144 ILLUMINA ss3772921864 Jul 13, 2019 (153)
145 PACBIO ss3785884327 Jul 13, 2019 (153)
146 PACBIO ss3791176525 Jul 13, 2019 (153)
147 PACBIO ss3796056476 Jul 13, 2019 (153)
148 KHV_HUMAN_GENOMES ss3810001968 Jul 13, 2019 (153)
149 EVA ss3824288284 Apr 26, 2020 (154)
150 EVA ss3825524282 Apr 26, 2020 (154)
151 EVA ss3825540101 Apr 26, 2020 (154)
152 EVA ss3825722592 Apr 26, 2020 (154)
153 EVA ss3830685588 Apr 26, 2020 (154)
154 EVA ss3838840839 Apr 26, 2020 (154)
155 EVA ss3844295633 Apr 26, 2020 (154)
156 SGDP_PRJ ss3867816259 Apr 26, 2020 (154)
157 KRGDB ss3915076667 Apr 26, 2020 (154)
158 KOGIC ss3962028160 Apr 26, 2020 (154)
159 FSA-LAB ss3984371703 Apr 26, 2021 (155)
160 FSA-LAB ss3984371704 Apr 26, 2021 (155)
161 EVA ss3984591227 Apr 26, 2021 (155)
162 EVA ss3986040318 Apr 26, 2021 (155)
163 EVA ss3986387889 Apr 26, 2021 (155)
164 TOPMED ss4753634726 Apr 26, 2021 (155)
165 TOMMO_GENOMICS ss5184286919 Apr 26, 2021 (155)
166 EVA ss5237034520 Apr 26, 2021 (155)
167 1000Genomes NC_000007.13 - 87138645 Oct 12, 2018 (152)
168 The Avon Longitudinal Study of Parents and Children NC_000007.13 - 87138645 Oct 12, 2018 (152)
169 Genome-wide autozygosity in Daghestan NC_000007.12 - 86976581 Apr 26, 2020 (154)
170 Genetic variation in the Estonian population NC_000007.13 - 87138645 Oct 12, 2018 (152)
171 ExAC NC_000007.13 - 87138645 Oct 12, 2018 (152)
172 FINRISK NC_000007.13 - 87138645 Apr 26, 2020 (154)
173 The Danish reference pan genome NC_000007.13 - 87138645 Apr 26, 2020 (154)
174 gnomAD - Genomes NC_000007.14 - 87509329 Apr 26, 2021 (155)
175 gnomAD - Exomes NC_000007.13 - 87138645 Jul 13, 2019 (153)
176 GO Exome Sequencing Project NC_000007.13 - 87138645 Oct 12, 2018 (152)
177 Genome of the Netherlands Release 5 NC_000007.13 - 87138645 Apr 26, 2020 (154)
178 HapMap NC_000007.14 - 87509329 Apr 26, 2020 (154)
179 KOREAN population from KRGDB NC_000007.13 - 87138645 Apr 26, 2020 (154)
180 Korean Genome Project NC_000007.14 - 87509329 Apr 26, 2020 (154)
181 Medical Genome Project healthy controls from Spanish population NC_000007.13 - 87138645 Apr 26, 2020 (154)
182 Northern Sweden NC_000007.13 - 87138645 Jul 13, 2019 (153)
183 The PAGE Study NC_000007.14 - 87509329 Jul 13, 2019 (153)
184 CNV burdens in cranial meningiomas NC_000007.13 - 87138645 Apr 26, 2021 (155)
185 Qatari NC_000007.13 - 87138645 Apr 26, 2020 (154)
186 SGDP_PRJ NC_000007.13 - 87138645 Apr 26, 2020 (154)
187 Siberian NC_000007.13 - 87138645 Apr 26, 2020 (154)
188 8.3KJPN NC_000007.13 - 87138645 Apr 26, 2021 (155)
189 TopMed NC_000007.14 - 87509329 Apr 26, 2021 (155)
190 UK 10K study - Twins NC_000007.13 - 87138645 Oct 12, 2018 (152)
191 A Vietnamese Genetic Variation Database NC_000007.13 - 87138645 Jul 13, 2019 (153)
192 ALFA NC_000007.14 - 87509329 Apr 26, 2021 (155)
193 ClinVar RCV000014699.2 Oct 12, 2018 (152)
194 ClinVar RCV000211142.1 Oct 12, 2018 (152)
195 ClinVar RCV000211266.1 Oct 12, 2018 (152)
196 ClinVar RCV000211276.1 Oct 12, 2018 (152)
197 ClinVar RCV000211363.1 Oct 12, 2018 (152)
198 ClinVar RCV000441548.1 Oct 12, 2018 (152)
199 ClinVar RCV000602614.1 Oct 12, 2018 (152)
200 ClinVar RCV000660758.1 Oct 12, 2018 (152)
201 ClinVar RCV000660759.1 Oct 12, 2018 (152)
202 ClinVar RCV000660760.1 Oct 12, 2018 (152)
203 ClinVar RCV000660761.1 Oct 12, 2018 (152)
204 ClinVar RCV000660762.1 Oct 12, 2018 (152)
205 ClinVar RCV000660763.1 Oct 12, 2018 (152)
206 ClinVar RCV000835732.1 Apr 26, 2020 (154)
207 ClinVar RCV001029504.1 Apr 26, 2020 (154)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs2229108 Jan 04, 2002 (102)
rs9690664 Feb 27, 2004 (120)
rs10239679 Feb 27, 2004 (120)
rs11568726 Apr 05, 2004 (121)
rs17210003 Oct 08, 2004 (123)
rs60023214 May 25, 2008 (130)
rs117328163 Aug 16, 2010 (132)
rs386513066 Aug 21, 2014 (142)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
22254061, ss3915076667 NC_000007.13:87138644:A:C NC_000007.14:87509328:A:C (self)
ss35092270, ss84662917 NC_000007.11:86783295:A:G NC_000007.14:87509328:A:G (self)
473506, ss66452652, ss76244224, ss112311473, ss114052258, ss116181203, ss162505427, ss164774216, ss172950537, ss203606929, ss279425977, ss293910902, ss479271043, ss491275584, ss491909106, ss1397499383, ss1594082757, ss1712968766, ss2635174036, ss2710663301, ss3643643278 NC_000007.12:86976580:A:G NC_000007.14:87509328:A:G (self)
38015919, 21154504, 15069254, 8873745, 49721, 8459027, 5701148, 746241, 9446145, 22254061, 286344, 8119198, 140652, 9811965, 19833239, 5304475, 42256226, 21154504, 4718508, ss223187915, ss234063912, ss241001912, ss342238477, ss479273892, ss479646961, ss484436125, ss490948047, ss491401201, ss536606462, ss560134735, ss654533775, ss778356341, ss782664531, ss783633368, ss831915095, ss832636978, ss833811086, ss974464787, ss984506888, ss1067489400, ss1074771513, ss1326013973, ss1431200590, ss1582294088, ss1584053260, ss1618630416, ss1661624449, ss1688802986, ss1711170584, ss1752698099, ss1805098504, ss1927770035, ss1946213129, ss1959029210, ss1970753045, ss2024567436, ss2152788121, ss2464894451, ss2626775179, ss2634628850, ss2634628851, ss2708492793, ss2736538737, ss2747854033, ss2855815012, ss2985411524, ss2986042871, ss3001577507, ss3023063080, ss3029637883, ss3347717361, ss3625932195, ss3629856411, ss3632535049, ss3633469219, ss3634194450, ss3635128944, ss3635874113, ss3636862402, ss3637627104, ss3638708191, ss3640836236, ss3644946230, ss3646358864, ss3654172888, ss3669331006, ss3734834333, ss3744292469, ss3745428961, ss3766828464, ss3772921864, ss3785884327, ss3791176525, ss3796056476, ss3824288284, ss3825524282, ss3825540101, ss3825722592, ss3830685588, ss3838840839, ss3867816259, ss3915076667, ss3984371703, ss3984371704, ss3984591227, ss3986040318, ss3986387889, ss5184286919 NC_000007.13:87138644:A:G NC_000007.14:87509328:A:G (self)
RCV000014699.2, RCV000211142.1, RCV000211266.1, RCV000211276.1, RCV000211363.1, RCV000441548.1, RCV000660758.1, RCV000660759.1, RCV000660760.1, RCV000660761.1, RCV000660762.1, RCV000660763.1, RCV000835732.1, RCV001029504.1, 268202350, 3438423, 18406161, 602782, 369630933, 591012285, 7105397364, ss2295530964, ss3026077180, ss3536823730, ss3648694776, ss3720146019, ss3771381313, ss3810001968, ss3844295633, ss3962028160, ss4753634726, ss5237034520 NC_000007.14:87509328:A:G NC_000007.14:87509328:A:G (self)
ss11850648 NT_007933.12:12372860:A:G NC_000007.14:87509328:A:G (self)
ss13491476, ss14109462 NT_007933.13:12372860:A:G NC_000007.14:87509328:A:G (self)
ss1516019, ss3189038, ss3226651, ss5602934, ss24420709, ss35072275, ss48292336, ss65736313, ss69021329, ss69365429, ss69365430, ss69365642, ss69366457, ss69366472, ss69366742, ss69369686, ss69369753, ss69369879, ss74872185, ss77104356, ss79313675, ss84172890, ss84172932, ss84172983, ss86271714, ss98315192, ss104448230, ss105107793, ss105109711, ss105109973, ss119379841, ss143599552, ss152729403, ss155153917, ss159124265, ss159715056, ss159895285, ss160865039, ss160865216, ss170100088, ss244268994 NT_007933.15:25171487:A:G NC_000007.14:87509328:A:G (self)
ss105109973 NT_007933.15:25171487:A:T NC_000007.14:87509328:A:T (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

561 citations for rs1045642
PMID Title Author Year Journal
10716719 Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Hoffmeyer S et al. 2000 Proceedings of the National Academy of Sciences of the United States of America
11502320 Frequency of C3435T polymorphism of MDR1 gene in African people. Schaeffeler E et al. 2001 Lancet (London, England)
12189368 Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein. Kurata Y et al. 2002 Clinical pharmacology and therapeutics
12686700 Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. Siddiqui A et al. 2003 The New England journal of medicine
15197162 Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene. Soranzo N et al. 2004 Genome research
15452305 Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy. Zimprich F et al. 2004 Neurology
15452306 Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy. Tan NC et al. 2004 Neurology
15805193 Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Tate SK et al. 2005 Proceedings of the National Academy of Sciences of the United States of America
16912956 Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity. Ritchie MD et al. 2006 Clinical infectious diseases
16912957 Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration. Haas DW et al. 2006 Clinical infectious diseases
16999857 ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients. Frankfort SV et al. 2006 Molecular neurodegeneration
17146660 Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers. Osswald E et al. 2007 European journal of clinical pharmacology
17185560 A "silent" polymorphism in the MDR1 gene changes substrate specificity. Kimchi-Sarfaty C et al. 2007 Science (New York, N.Y.)
17366837 Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada. Steinberg KK et al. 2007 Environmental health perspectives
17548681 MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. Urayama KY et al. 2007 Cancer epidemiology, biomarkers & prevention
17674045 No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients. Petrova DT et al. 2008 Journal of cancer research and clinical oncology
17898703 Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Campa D et al. 2008 Clinical pharmacology and therapeutics
17913323 ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Kato M et al. 2008 Progress in neuro-psychopharmacology & biological psychiatry
18182569 Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group. Davies SM et al. 2008 Blood
18213362 Multiplexed genotyping of ABC transporter polymorphisms with the Bioplex suspension array. Koo SH et al. 2007 Biological procedures online
18285546 A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. French D et al. 2008 Blood
18334914 Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration. Aarnoudse AJ et al. 2008 Pharmacogenetics and genomics
18424454 ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence. Levran O et al. 2008 Human molecular genetics
18518969 Association of ABCB1 genetic variants with renal function in Africans and in Caucasians. Bochud M et al. 2008 BMC medical genomics
18547414 Genotyping panel for assessing response to cancer chemotherapy. Dai Z et al. 2008 BMC medical genomics
18698231 Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. Johnson AD et al. 2008 Pharmacogenetics and genomics
18725235 Bidirectional translational research: Progress in understanding addictive diseases. Kreek MJ et al. 2009 Neuropharmacology
18784455 The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis. Gupta SK et al. 2008 AIDS (London, England)
18812236 No association of ABCB1 polymorphisms with drug-refractory epilepsy in a north Indian population. Lakhan R et al. 2009 Epilepsy & behavior
18831695 Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir. Siccardi M et al. 2008 Clinical infectious diseases
18854777 Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy. Wu X et al. 2008 Pharmacogenetics and genomics
18936436 Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Chang MH et al. 2009 American journal of epidemiology
19155191 Opiate and cocaine addiction: from bench to clinic and back to the bench. Kreek MJ et al. 2009 Current opinion in pharmacology
19193698 Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate. Lee YC et al. 2009 Rheumatology (Oxford, England)
19197249 Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain. Tripodi G et al. 2009 American journal of hypertension
19285141 Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response. Liu J et al. 2009 NeuroImage
19373654 ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma. Drain S et al. 2009 Leukemia & lymphoma
19403460 Pharmacogenetics of antidepressant response: an update. Drago A et al. 2009 Human genomics
19437139 ABCB1 single nucleotide polymorphisms in the Brazilian population. Scheiner MA et al. 2010 Molecular biology reports
19442035 Pharmacogenomics of platinum-based chemotherapy in NSCLC. Hildebrandt MA et al. 2009 Expert opinion on drug metabolism & toxicology
19514130 Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers. Lötsch J et al. 2009 Pharmacogenetics and genomics
19617466 CYP2C9, CYP2C19, and ABCB1 genotype and hospitalization for phenytoin toxicity. Hennessy S et al. 2009 Journal of clinical pharmacology
19694740 No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin. Keskitalo JE et al. 2009 British journal of clinical pharmacology
19706858 Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. Shuldiner AR et al. 2009 JAMA
19740399 Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant. Hawwa AF et al. 2009 British journal of clinical pharmacology
19812066 Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women. Chantarangsu S et al. 2009 The Journal of antimicrobial chemotherapy
19819348 Comparative description of haplotype structure and genetic diversity of MDR1 (ABCB1) in HIV-positive and HIV-negative populations. Benish RL et al. 2010 Infection, genetics and evolution
19890215 CYP2C19 genetic variants affect nelfinavir pharmacokinetics and virologic response in HIV-1-infected children receiving highly active antiretroviral therapy. Saitoh A et al. 2010 Journal of acquired immune deficiency syndromes (1999)
19896927 Modulation of human placental P-glycoprotein expression and activity by MDR1 gene polymorphisms. Hemauer SJ et al. 2010 Biochemical pharmacology
19916993 A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans. Mukonzo JK et al. 2009 British journal of clinical pharmacology
19924384 Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors. Steeghs N et al. 2011 Investigational new drugs
19930591 Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. Andersen V et al. 2009 BMC cancer
19934400 Genetic predictors of interindividual variability in hepatic CYP3A4 expression. Lamba V et al. 2010 The Journal of pharmacology and experimental therapeutics
20017669 Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique. Ciccacci C et al. 2010 Pharmacogenomics
20170205 Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I. Staatz CE et al. 2010 Clinical pharmacokinetics
20177420 Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Glimelius B et al. 2011 The pharmacogenomics journal
20201854 Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Yuferov V et al. 2010 Annals of the New York Academy of Sciences
20214406 Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II. Staatz CE et al. 2010 Clinical pharmacokinetics
20216335 Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein). Hodges LM et al. 2011 Pharmacogenetics and genomics
20354687 Explaining variability in ciclosporin exposure in adult kidney transplant recipients. Press RR et al. 2010 European journal of clinical pharmacology
20357209 Molecular genetic studies of gene identification for osteoporosis: the 2009 update. Xu XH et al. 2010 Endocrine reviews
20389299 Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. Xu CF et al. 2010 British journal of cancer
20440227 Clopidogrel pathway. Sangkuhl K et al. 2010 Pharmacogenetics and genomics
20505666 Donor P-gp polymorphisms strongly influence renal function and graft loss in a cohort of renal transplant recipients on cyclosporine therapy in a long-term follow-up. Woillard JB et al. 2010 Clinical pharmacology and therapeutics
20531015 Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDS. Sezgin E et al. 2010 Journal of acquired immune deficiency syndromes (1999)
20532504 Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin. Buda G et al. 2010 Annals of hematology
20533057 ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer. Balcerczak E et al. 2010 International journal of colorectal disease
20602618 Irinotecan pharmacogenomics. Marsh S et al. 2010 Pharmacogenomics
20617924 Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS. Sezgin E et al. 2010 The Journal of infectious diseases
20628376 Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients. Fajac A et al. 2010 British journal of cancer
20696882 Population pharmacokinetic-pharmacogenetic study of nevirapine in HIV-infected Cambodian patients. Chou M et al. 2010 Antimicrobial agents and chemotherapy
20707787 Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting. Choi EM et al. 2010 Anaesthesia
20801494 Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. Mega JL et al. 2010 Lancet (London, England)
20859246 ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment. Lin KM et al. 2011 Pharmacogenetics and genomics
20921971 Mapping genes that predict treatment outcome in admixed populations. Baye TM et al. 2010 The pharmacogenomics journal
20948663 The ABCB1 transporter gene and antidepressant response. Peters EJ et al. 2009 F1000 biology reports
21048526 Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF et al. 2011 Pharmacogenetics and genomics
21102498 Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients. Onizuka M et al. 2011 Bone marrow transplantation
21122163 The pharmacogenetics of imanitib. Dulucq S et al. 2010 Genome medicine
21160409 Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population. Petrovski S et al. 2011 AIDS (London, England)
21172166 Pharmacogenetics of antidepressant response. Porcelli S et al. 2011 Journal of psychiatry & neuroscience
21185600 Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia. Maffioli M et al. 2011 Leukemia research
21197270 Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Non-nucleoside Reverse Transcriptase Inhibitors. Saitoh A et al. 2008 Future HIV therapy
21197301 Recent advances in the use of opioids for cancer pain. Droney J et al. 2009 Journal of pain research
21219401 Evaluation of limited sampling methods for estimation of tacrolimus exposure in adult kidney transplant recipients. Barraclough KA et al. 2011 British journal of clinical pharmacology
21247447 CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population. Santos PC et al. 2011 BMC medical genetics
21288825 Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study. Lubomirov R et al. 2011 The Journal of infectious diseases
21289622 Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy. Sadee W et al. 2011 Clinical pharmacology and therapeutics
21311724 Genetic polymorphisms of ATP-binding cassette (ABC) proteins, overall survival and drug toxicity in patients with Acute Myeloid Leukemia. Hampras SS et al. 2010 International journal of molecular epidemiology and genetics
21332314 Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally advanced esophageal cancer. Narumiya K et al. 2011 Pharmacogenomics
21333900 The role of genetics in IBS. Saito YA et al. 2011 Gastroenterology clinics of North America
21358751 Identification of CYP2C19*4B: pharmacogenetic implications for drug metabolism including clopidogrel responsiveness. Scott SA et al. 2012 The pharmacogenomics journal
21364332 Ultra-resistant schizophrenia is not associated with the multidrug-resistant transporter 1 (MDR1) gene rs1045642 variant. Mouaffak F et al. 2011 Journal of clinical psychopharmacology
21383334 Lack of association of OPRM1 and ABCB1 single-nucleotide polymorphisms to oxycodone response in postoperative pain. Zwisler ST et al. 2012 Journal of clinical pharmacology
21441680 Profiling single nucleotide polymorphisms (SNPs) across intracellular folate metabolic pathway in healthy Indians. Ghodke Y et al. 2011 The Indian journal of medical research
21468756 The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients. Chew SC et al. 2011 Cancer chemotherapy and pharmacology
21544031 Expression of CYP3A5 and P-glycoprotein in renal allografts with histological signs of calcineurin inhibitor nephrotoxicity. Metalidis C et al. 2011 Transplantation
21553324 Polymorphisms of the MDR1 and MIF genes in children with nephrotic syndrome. Choi HJ et al. 2011 Pediatric nephrology (Berlin, Germany)
21615938 Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder. Aneiros-Guerrero A et al. 2011 BMC medical genetics
21673041 Chemokine (C-C motif) receptor 5 -2459 genotype in patients receiving highly active antiretroviral therapy: race-specific influence on virologic success. Mehlotra RK et al. 2011 The Journal of infectious diseases
21686133 Polymorphisms in ABCB1 and ERCC2 associated with ovarian cancer outcome. Peethambaram P et al. 2011 International journal of molecular epidemiology and genetics
21687501 Pharmacogenetics of antidepressants. Crisafulli C et al. 2011 Frontiers in pharmacology
21705081 Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma. Drain S et al. 2011 Leukemia research
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30559675 Lipid Transporter Activity-Related Genetic Polymorphisms Are Associated With Steroid-Induced Osteonecrosis of the Femoral Head: An Updated Meta-Analysis Based on the GRADE Guidelines. Chen X et al. 2018 Frontiers in physiology
30637776 Influence of ABCB1 C3435T and C1236T gene polymorphisms on tumour response to docetaxel-based neo-adjuvant chemotherapy in locally advanced breast cancer patients of South India. Priyadarshini R et al. 2019 Journal of clinical pharmacy and therapeutics
30713338 Is a pharmacogenomic panel useful to estimate the risk of oxaliplatin-related neurotoxicity in colorectal cancer patients? Nichetti F et al. 2019 The pharmacogenomics journal
30729282 The role of ABCB1 polymorphism as a prognostic marker for primary central nervous system lymphoma. Wu T et al. 2019 Annals of hematology
30742211 Association Between ABCB1 Polymorphisms and Outcomes of Clopidogrel Treatment in Patients With Minor Stroke or Transient Ischemic Attack: Secondary Analysis of a Randomized Clinical Trial. Pan Y et al. 2019 JAMA neurology
30760877 Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits. Li J et al. 2019 The pharmacogenomics journal
30781715 Genetic Epidemiology of Breast Cancer in Latin America. Zavala VA et al. 2019 Genes
30796464 ABCB1 c.3435C&gt;T polymorphism is associated with platinum toxicity: a preliminary study. De Troia B et al. 2019 Cancer chemotherapy and pharmacology
30901313 Acute rejection in kidney transplantation and the evaluation of associated polymorphisms (SNPs): the importance of sample size. Neri A et al. 2019 Diagnosis (Berlin, Germany)
30996113 Association between genetic polymorphisms and osteonecrosis in steroid treatment populations: a detailed stratified and dose-response meta-analysis. Yang J et al. 2019 Bioscience reports
31085105 Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management. Yang GS et al. 2019 Seminars in oncology nursing
31086207 Implications of genetic variation of common Drug Metabolizing Enzymes and ABC Transporters among the Pakistani Population. Afsar NA et al. 2019 Scientific reports
31099054 Membrane-Spanning Protein Genetic Polymorphisms Related to Methotrexate Therapeutic Outcomes in a Chinese Rheumatoid Arthritis Population. Lv S et al. 2019 Journal of clinical pharmacology
31113932 ABCB1 SNP predicts outcome in patients with acute myeloid leukemia treated with Gemtuzumab ozogamicin: a report from Children's Oncology Group AAML0531 Trial. Rafiee R et al. 2019 Blood cancer journal
31124417 <i>NR3C1</i>, <i>ABCB1</i>, <i>TNF</i> and <i>CYP2C19</i> polymorphisms association with the response to the treatment of erythema nodosum leprosum. do Socorro Silva Costa P et al. 2019 Pharmacogenomics
31184624 [Genetic and non-genetic factors of laboratory resistance to clopidogrel in patients with ischemic stroke]. Sychev DA et al. 2019 Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
31234681 A meta-analysis of <i>MDR1</i> polymorphisms rs1128503 and rs1045642 and susceptibility to hepatocellular carcinoma. Chang Q et al. 2019 The Journal of international medical research
31270413
31333472 <i>ABCB1</i> Gene Is Associated With Clinical Response to SNRIs in a Local Chinese Han Population. Shan XX et al. 2019 Frontiers in pharmacology
31346154 Influence of (ATP)-Binding Cassette Transporter Subfamily B Member 1 (ABCB1) Gene Polymorphism on the Efficacy of Remifentanil. Wang W et al. 2019 Medical science monitor
31391850 Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients. Al-Eitan LN et al. 2019 Journal of oncology
31543510 Association of CYP2C19 Polymorphism with Clopidogrel Resistance in Patients with Acute Coronary Syndrome in China. Su Q et al. 2019 Medical science monitor
31617197 Effect of CYP3A4, CYP3A5, ABCB1 Gene Polymorphisms on Rivaroxaban Pharmacokinetics in Patients Undergoing Total Hip and Knee Replacement Surgery. Sychev D et al. 2019 High blood pressure & cardiovascular prevention
31634334 Modification of the association between paroxetine serum concentration and SERT-occupancy by ABCB1 (P-glycoprotein) polymorphisms in major depressive disorder. Simoons M et al. 2020 Psychiatric genetics
31738228 A functional polymorphism in the ATP-Binding Cassette B1 transporter predicts pharmacologic response to combination of nortriptyline and morphine in neuropathic pain patients. Benavides R et al. 2020 Pain
31780765 Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial. Gómez-Silva M et al. 2019 Scientific reports
31818908 Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer. Montazeri Z et al. 2020 Gut
31854268 Impact of <i>CYP2C9</i>, <i>VKORC1</i>, <i>ApoE</i> and <i>ABCB1</i> polymorphisms on stable warfarin dose requirements in elderly Chinese patients. Li W et al. 2020 Pharmacogenomics
31874497 [Effect of opioid-related gene polymorphisms on patients with high-dose opioid-tolerant cancer pain]. Xie GL et al. 2019 Zhonghua yi xue za zhi
31893292 The influence of single-nucleotide polymorphisms on overall survival and toxicity in cabazitaxel-treated patients with metastatic castration-resistant prostate cancer. Belderbos BPS et al. 2020 Cancer chemotherapy and pharmacology
31948121 The Association between <i>ABCB1</i> C1236T/C3435T SNPs and <i>H. pylori</i> Infection among Jordanians. BaniHani MN et al. 2020 Genes
31981210 Genetic Polymorphisms Affecting Cardiac Biomarker Concentrations in Children with Cancer: an Analysis from the "European Paediatric Oncology Off-patents Medicines Consortium" (EPOC) Trial. Hellmann F et al. 2020 European journal of drug metabolism and pharmacokinetics
32015454 Association study of genetic polymorphisms in proteins involved in oseltamivir transport, metabolism, and interactions with adverse reactions in Mexican patients with acute respiratory diseases. Bermúdez de León M et al. 2020 The pharmacogenomics journal
32042261 Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population. Zeliha KP et al. 2020 Saudi pharmaceutical journal
32042822 The analysis of pharmacokinetic and pharmacogenomic impact on gefitinib efficacy in advanced non-small cell lung cancer patients: results from a prospective cohort study. Ma Y et al. 2019 Annals of translational medicine
32051713 The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer. Mrozikiewicz-Rakowska B et al. 2020 Archives of medical science
32070304 The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine. Hattori S et al. 2020 BMC psychiatry
32080102 Association between ABCB1 (3435C&gt;T) polymorphism and susceptibility of colorectal cancer: A meta-analysis. Han LL et al. 2020 Medicine
32134727 Effect of CES1 and ABCB1 genotypes on the pharmacokinetics and clinical outcomes of dabigatran etexilate in patients with atrial fibrillation and chronic kidney disease. Sychev D et al. 2020 Drug metabolism and personalized therapy
32149782 Sex Bias and Genotype Influence on Opioid Safety Profile in Chronic Low Back Pain. Margarit C et al. 2020 The Clinical journal of pain
32162036 Genetic polymorphisms and multiple myeloma risk: a meta-analysis. Zhang P et al. 2020 Annals of hematology
32228310 Functionally Significant Coumarin-Related Variant Alleles and Time to Therapeutic Range in Chilean Cardiovascular Patients. Rojo M et al. 2020 Clinical and applied thrombosis/hemostasis
32243098 Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patients. Li B et al. 2020 Molecular genetics & genomic medicine
32271961 The impacts of gene polymorphisms on methotrexate in Chinese psoriatic patients. Chen M et al. 2020 Journal of the European Academy of Dermatology and Venereology
32303955 Clinically relevant pharmacogenetic markers in Tatars and Balkars. Abdullaev SP et al. 2020 Molecular biology reports
32316515 Interindividual Variability of Apixaban Plasma Concentrations: Influence of Clinical and Genetic Factors in a Real-Life Cohort of Atrial Fibrillation Patients. Roşian AN et al. 2020 Genes
32326111 Role of Genetic Variations in the Hepatic Handling of Drugs. Marin JJG et al. 2020 International journal of molecular sciences
32327994 A Pharmacogenetically Guided Acenocoumarol Dosing Algorithm for Chilean Patients: A Discovery Cohort Study. Roco A et al. 2020 Frontiers in pharmacology
32368972 Genetic Analysis of Pharmacogenomic VIP Variants of ABCB1, VDR and TPMT Genes in an Ethnically Isolated Population from the North Caucasus Living in Jordan. Al-Eitan LN et al. 2020 Current drug metabolism
32399998 Influence of ABCB-1, ERCC-1 and ERCC-2 gene polymorphisms on response to capecitabine and oxaliplatin (CAPOX) treatment in colorectal cancer (CRC) patients of South India. Varma A et al. 2020 Journal of clinical pharmacy and therapeutics
32406606 Positive detection of SARS-CoV-2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non-conjunctivitis COVID-19 patient with obstruction of common lacrimal duct. Hu Y et al. 2020 Acta ophthalmologica
32426102 Are gene polymorphisms related to adverse events of methotrexate in patients with rheumatoid arthritis? A retrospective cohort study based on an updated meta-analysis. Huang J et al. 2020 Therapeutic advances in chronic disease
32457604 Possible Genetic Determinants of Response to Phenytoin in a Group of Colombian Patients With Epilepsy. Calderon-Ospina CA et al. 2020 Frontiers in pharmacology
32483134 The atorvastatin metabolic phenotype shift is influenced by interaction of drug-transporter polymorphisms in Mexican population: results of a randomized trial. León-Cachón RBR et al. 2020 Scientific reports
32611208 Different response rates to chemotherapy between Japanese and German esophageal squamous cell carcinoma: patients may be influenced by <i>ERCC1</i> or <i>ABCB1</i>. Narumiya K et al. 2020 Future oncology (London, England)
32687695 Effects of ABCB1, UGT1A1, and UGT1A9 Genetic Polymorphisms on the Pharmacokinetics of Sitafloxacin Granules in Healthy Subjects. Sun LN et al. 2021 Clinical pharmacology in drug development
32695000 <i>ABCB1</i> Genetic Variants as Predictors of Irinotecan-Induced Severe Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients. Riera P et al. 2020 Frontiers in pharmacology
32695297 Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia. Esmaili MA et al. 2020 Iranian journal of basic medical sciences
32780457 Pharmacogenetics for severe adverse drug reactions induced by molecular-targeted therapy. Udagawa C et al. 2020 Cancer science
32827391 Pharmacogenetics of antipsychotics in adolescents with acute psychotic episode during first 14 days after admission: effectiveness and safety evaluation. Ivashchenko DV et al. 2020 Drug metabolism and personalized therapy
32849848 Beyond Single Nucleotide Polymorphisms: <i>CYP3A5<sup>∗</sup>3<sup>∗</sup>6<sup>∗</sup>7</i> Composite and <i>ABCB1</i> Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients. Brazeau DA et al. 2020 Frontiers in genetics
32862511 Distribution of CYP2C19, ABCB1 and PON1 polymorphisms in Chinese Han, Hui, Uygur and Kazak patients with coronary atherosclerotic heart disease. Ma L et al. 2020 International journal of immunogenetics
32872162 Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450. Hlaváč V et al. 2020 Journal of personalized medicine
32899083 Left atrial appendage thrombus formation in a patient with atrial fibrillation on dabigatran therapy associated with CES1 and ABCB1 genetic polymorphisms: A case report. Wu T et al. 2020 Medicine
32936528 Important Pharmacogenetic Information for Drugs Prescribed During the SARS-CoV-2 Infection (COVID-19). Zubiaur P et al. 2020 Clinical and translational science
32961964 An Exploratory Association Analysis of <i>ABCB</i><sub>1</sub> rs1045642 and <i>ABCB</i><sub>1</sub> rs4148738 with Non-Major Bleeding Risk in Atrial Fibrillation Patients Treated with Dabigatran or Apixaban. Roşian AN et al. 2020 Journal of personalized medicine
32992097 Association of the genetic polymorphisms of metabolizing enzymes, transporters, target receptors and their interactions with treatment response to olanzapine in chinese han schizophrenia patients. Yan P et al. 2020 Psychiatry research
33025511 Population Pharmacokinetic Model of Plasma and Cellular Mycophenolic Acid in Kidney Transplant Patients from the CIMTRE Study. Riglet F et al. 2020 Drugs in R&D
33035787 Effect of DPYD, MTHFR, ABCB1, XRCC1, ERCC1 and GSTP1 on chemotherapy related toxicity in colorectal carcinoma. Puerta-García E et al. 2020 Surgical oncology
33050895 Population structure and pharmacogenomic risk stratification in the United States. Nagar SD et al. 2020 BMC biology
33124772 Impact of CYP2C19, CYP3A4, ABCB1, and FMO3 genotypes on plasma voriconazole in Thai patients with invasive fungal infections. Chuwongwattana S et al. 2020 Pharmacology research & perspectives
33125673 Association of plasma docetaxel levels with ABCB1 gene polymorphisms and tumour response in locally advanced breast cancer patients of South India on neo-adjuvant chemotherapy. Priyadarshini R et al. 2021 Breast cancer (Tokyo, Japan)
33226983 Genetic and pharmacological relationship between P-glycoprotein and increased cardiovascular risk associated with clarithromycin prescription: An epidemiological and genomic population-based cohort study in Scotland, UK. Mordi IR et al. 2020 PLoS medicine
33232268 A SNP involved in alternative splicing of <i>ABCB1</i> is associated with clopidogrel resistance in coronary heart disease in Chinese population. Zhang S et al. 2020 Aging
33262486 Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters. 2020 European journal of human genetics
33312066 Pharmacogenomics landscape of COVID-19 therapy response in Serbian population and comparison with worldwide populations. Stanković B et al. 2020 Journal of medical biochemistry
33319444 The effect of acute morphine on sleep in male patients suffering from sleep apnea: Is there a genetic effect? An RCT Study. Rowsell L et al. 2021 Journal of sleep research
33323685 The association of transporter ABCC2 (MRP2) genetic variation and drug-induced hyperbilirubinemia. Huang YS et al. 2021 Journal of the Chinese Medical Association
33326171 GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer. Ferracini AC et al. 2021 Clinical and translational science
33454797 Brain/blood ratios of methadone and ABCB1 polymorphisms in methadone-related deaths. Iwersen-Bergmann S et al. 2021 International journal of legal medicine
33646566 Tacrolimus dose, blood concentrations and acute nephrotoxicity, but not CYP3A5/ABCB1 genetics, are associated with allograft tacrolimus concentrations in renal transplant recipients. Sallustio BC et al. 2021 British journal of clinical pharmacology
33709789 Polymorphism of <i>FGD4</i> and myelosuppression in patients with esophageal squamous cell carcinoma. Yang Y et al. 2021 Future oncology (London, England)
Help

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post596+ae089ad