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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs10074959

Current Build 155

Released April 9, 2021

Organism
Homo sapiens
Position
chr5:104872312 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
G>A
Variation Type
SNV Single Nucleotide Variation
Frequency
A=0.300869 (79637/264690, TOPMED)
A=0.248465 (63354/254982, ALFA)
A=0.302876 (42359/139856, GnomAD) (+ 20 more)
A=0.33023 (25990/78702, PAGE_STUDY)
A=0.26933 (4514/16760, 8.3KJPN)
A=0.2893 (1449/5008, 1000G)
A=0.2362 (1058/4480, Estonian)
A=0.2281 (879/3854, ALSPAC)
A=0.2403 (891/3708, TWINSUK)
A=0.2461 (721/2930, KOREAN)
A=0.2726 (568/2084, HGDP_Stanford)
A=0.3228 (610/1890, HapMap)
A=0.2396 (439/1832, Korea1K)
A=0.2139 (243/1136, Daghestan)
A=0.251 (250/998, GoNL)
A=0.217 (172/792, PRJEB37584)
A=0.305 (183/600, NorthernSweden)
G=0.420 (94/224, SGDP_PRJ)
A=0.273 (59/216, Qatari)
A=0.318 (68/214, Vietnamese)
A=0.22 (14/64, Ancient Sardinia)
A=0.28 (11/40, GENOME_DK)
G=0.47 (16/34, Siberian)
Clinical Significance
Not Reported in ClinVar
Gene : Consequence
None
Publications
1 citation
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 5 NC_000005.10:g.104872312G>A
GRCh37.p13 chr 5 NC_000005.9:g.104208013G>A
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 254982 G=0.751535 A=0.248465
European Sub 228674 G=0.759610 A=0.240390
African Sub 10128 G=0.55085 A=0.44915
African Others Sub 380 G=0.489 A=0.511
African American Sub 9748 G=0.5532 A=0.4468
Asian Sub 3850 G=0.7540 A=0.2460
East Asian Sub 3120 G=0.7436 A=0.2564
Other Asian Sub 730 G=0.799 A=0.201
Latin American 1 Sub 972 G=0.719 A=0.281
Latin American 2 Sub 2570 G=0.8167 A=0.1833
South Asian Sub 368 G=0.859 A=0.141
Other Sub 8420 G=0.7517 A=0.2483


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 G=0.699131 A=0.300869
gnomAD - Genomes Global Study-wide 139856 G=0.697124 A=0.302876
gnomAD - Genomes European Sub 75818 G=0.75704 A=0.24296
gnomAD - Genomes African Sub 41866 G=0.54913 A=0.45087
gnomAD - Genomes American Sub 13598 G=0.78754 A=0.21246
gnomAD - Genomes Ashkenazi Jewish Sub 3322 G=0.7787 A=0.2213
gnomAD - Genomes East Asian Sub 3106 G=0.7312 A=0.2688
gnomAD - Genomes Other Sub 2146 G=0.7190 A=0.2810
The PAGE Study Global Study-wide 78702 G=0.66977 A=0.33023
The PAGE Study AfricanAmerican Sub 32516 G=0.55351 A=0.44649
The PAGE Study Mexican Sub 10810 G=0.81452 A=0.18548
The PAGE Study Asian Sub 8318 G=0.7237 A=0.2763
The PAGE Study PuertoRican Sub 7918 G=0.7469 A=0.2531
The PAGE Study NativeHawaiian Sub 4534 G=0.7097 A=0.2903
The PAGE Study Cuban Sub 4230 G=0.7284 A=0.2716
The PAGE Study Dominican Sub 3828 G=0.6460 A=0.3540
The PAGE Study CentralAmerican Sub 2450 G=0.7943 A=0.2057
The PAGE Study SouthAmerican Sub 1982 G=0.8002 A=0.1998
The PAGE Study NativeAmerican Sub 1260 G=0.7524 A=0.2476
The PAGE Study SouthAsian Sub 856 G=0.845 A=0.155
8.3KJPN JAPANESE Study-wide 16760 G=0.73067 A=0.26933
1000Genomes Global Study-wide 5008 G=0.7107 A=0.2893
1000Genomes African Sub 1322 G=0.4947 A=0.5053
1000Genomes East Asian Sub 1008 G=0.7252 A=0.2748
1000Genomes Europe Sub 1006 G=0.7545 A=0.2455
1000Genomes South Asian Sub 978 G=0.884 A=0.116
1000Genomes American Sub 694 G=0.793 A=0.207
Genetic variation in the Estonian population Estonian Study-wide 4480 G=0.7638 A=0.2362
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 G=0.7719 A=0.2281
UK 10K study - Twins TWIN COHORT Study-wide 3708 G=0.7597 A=0.2403
KOREAN population from KRGDB KOREAN Study-wide 2930 G=0.7539 A=0.2461
HGDP-CEPH-db Supplement 1 Global Study-wide 2084 G=0.7274 A=0.2726
HGDP-CEPH-db Supplement 1 Est_Asia Sub 470 G=0.781 A=0.219
HGDP-CEPH-db Supplement 1 Central_South_Asia Sub 414 G=0.761 A=0.239
HGDP-CEPH-db Supplement 1 Middle_Est Sub 350 G=0.694 A=0.306
HGDP-CEPH-db Supplement 1 Europe Sub 320 G=0.766 A=0.234
HGDP-CEPH-db Supplement 1 Africa Sub 242 G=0.504 A=0.496
HGDP-CEPH-db Supplement 1 America Sub 216 G=0.736 A=0.264
HGDP-CEPH-db Supplement 1 Oceania Sub 72 G=0.90 A=0.10
HapMap Global Study-wide 1890 G=0.6772 A=0.3228
HapMap American Sub 770 G=0.752 A=0.248
HapMap African Sub 690 G=0.568 A=0.432
HapMap Asian Sub 254 G=0.724 A=0.276
HapMap Europe Sub 176 G=0.710 A=0.290
Korean Genome Project KOREAN Study-wide 1832 G=0.7604 A=0.2396
Genome-wide autozygosity in Daghestan Global Study-wide 1136 G=0.7861 A=0.2139
Genome-wide autozygosity in Daghestan Daghestan Sub 628 G=0.812 A=0.188
Genome-wide autozygosity in Daghestan Near_East Sub 144 G=0.743 A=0.257
Genome-wide autozygosity in Daghestan Central Asia Sub 122 G=0.762 A=0.238
Genome-wide autozygosity in Daghestan Europe Sub 108 G=0.685 A=0.315
Genome-wide autozygosity in Daghestan South Asian Sub 98 G=0.82 A=0.18
Genome-wide autozygosity in Daghestan Caucasus Sub 36 G=0.81 A=0.19
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 G=0.749 A=0.251
CNV burdens in cranial meningiomas Global Study-wide 792 G=0.783 A=0.217
CNV burdens in cranial meningiomas CRM Sub 792 G=0.783 A=0.217
Northern Sweden ACPOP Study-wide 600 G=0.695 A=0.305
SGDP_PRJ Global Study-wide 224 G=0.420 A=0.580
Qatari Global Study-wide 216 G=0.727 A=0.273
A Vietnamese Genetic Variation Database Global Study-wide 214 G=0.682 A=0.318
Ancient Sardinia genome-wide 1240k capture data generation and analysis Global Study-wide 64 G=0.78 A=0.22
The Danish reference pan genome Danish Study-wide 40 G=0.72 A=0.28
Siberian Global Study-wide 34 G=0.47 A=0.53
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement G= A
GRCh38.p13 chr 5 NC_000005.10:g.104872312= NC_000005.10:g.104872312G>A
GRCh37.p13 chr 5 NC_000005.9:g.104208013= NC_000005.9:g.104208013G>A
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

105 SubSNP, 23 Frequency submissions
No Submitter Submission ID Date (Build)
1 WI_SSAHASNP ss13927952 Dec 05, 2003 (119)
2 CSHL-HAPMAP ss17861941 Feb 27, 2004 (120)
3 ILLUMINA ss66941922 Nov 29, 2006 (127)
4 ILLUMINA ss70984384 May 16, 2007 (127)
5 ILLUMINA ss75391447 Dec 06, 2007 (129)
6 HGSV ss84379242 Dec 16, 2007 (130)
7 1000GENOMES ss109279595 Jan 23, 2009 (130)
8 1000GENOMES ss112302808 Jan 25, 2009 (130)
9 ILLUMINA-UK ss116741695 Feb 14, 2009 (130)
10 KRIBB_YJKIM ss119612521 Dec 01, 2009 (131)
11 GMI ss155827998 Dec 01, 2009 (131)
12 ILLUMINA ss159859691 Dec 01, 2009 (131)
13 COMPLETE_GENOMICS ss162509617 Jul 04, 2010 (132)
14 COMPLETE_GENOMICS ss165628690 Jul 04, 2010 (132)
15 ILLUMINA ss169622008 Jul 04, 2010 (132)
16 BUSHMAN ss200623243 Jul 04, 2010 (132)
17 BCM-HGSC-SUB ss206921928 Jul 04, 2010 (132)
18 1000GENOMES ss221852789 Jul 14, 2010 (132)
19 1000GENOMES ss233070131 Jul 14, 2010 (132)
20 1000GENOMES ss240212261 Jul 15, 2010 (132)
21 BL ss253677271 May 09, 2011 (134)
22 GMI ss278410556 May 04, 2012 (137)
23 PJP ss293424821 May 09, 2011 (134)
24 ILLUMINA ss479177865 May 04, 2012 (137)
25 ILLUMINA ss479179937 May 04, 2012 (137)
26 ILLUMINA ss479505237 Sep 08, 2015 (146)
27 ILLUMINA ss484389998 May 04, 2012 (137)
28 ILLUMINA ss536572939 Sep 08, 2015 (146)
29 TISHKOFF ss558589719 Apr 25, 2013 (138)
30 SSMP ss652475387 Apr 25, 2013 (138)
31 ILLUMINA ss778346223 Sep 08, 2015 (146)
32 ILLUMINA ss782641337 Sep 08, 2015 (146)
33 ILLUMINA ss783610771 Sep 08, 2015 (146)
34 ILLUMINA ss831891532 Sep 08, 2015 (146)
35 ILLUMINA ss833800881 Sep 08, 2015 (146)
36 EVA-GONL ss981909278 Aug 21, 2014 (142)
37 JMKIDD_LAB ss1072883241 Aug 21, 2014 (142)
38 1000GENOMES ss1316402651 Aug 21, 2014 (142)
39 HAMMER_LAB ss1397422022 Sep 08, 2015 (146)
40 DDI ss1430444008 Apr 01, 2015 (144)
41 EVA_GENOME_DK ss1581267474 Apr 01, 2015 (144)
42 EVA_DECODE ss1591429479 Apr 01, 2015 (144)
43 EVA_UK10K_ALSPAC ss1613577591 Apr 01, 2015 (144)
44 EVA_UK10K_TWINSUK ss1656571624 Apr 01, 2015 (144)
45 EVA_SVP ss1712786478 Apr 01, 2015 (144)
46 ILLUMINA ss1752540217 Sep 08, 2015 (146)
47 HAMMER_LAB ss1803957901 Sep 08, 2015 (146)
48 WEILL_CORNELL_DGM ss1925161856 Feb 12, 2016 (147)
49 ILLUMINA ss1946151180 Feb 12, 2016 (147)
50 ILLUMINA ss1958809339 Feb 12, 2016 (147)
51 JJLAB ss2023187105 Sep 14, 2016 (149)
52 USC_VALOUEV ss2151344743 Dec 20, 2016 (150)
53 HUMAN_LONGEVITY ss2276439226 Dec 20, 2016 (150)
54 TOPMED ss2444716658 Dec 20, 2016 (150)
55 SYSTEMSBIOZJU ss2626087528 Nov 08, 2017 (151)
56 ILLUMINA ss2634316599 Nov 08, 2017 (151)
57 GRF ss2706902057 Nov 08, 2017 (151)
58 ILLUMINA ss2711044863 Nov 08, 2017 (151)
59 GNOMAD ss2828457036 Nov 08, 2017 (151)
60 SWEGEN ss2997471128 Nov 08, 2017 (151)
61 ILLUMINA ss3022513816 Nov 08, 2017 (151)
62 BIOINF_KMB_FNS_UNIBA ss3025377202 Nov 08, 2017 (151)
63 CSHL ss3346536001 Nov 08, 2017 (151)
64 TOPMED ss3473335196 Nov 08, 2017 (151)
65 ILLUMINA ss3625879565 Oct 12, 2018 (152)
66 ILLUMINA ss3629300871 Oct 12, 2018 (152)
67 ILLUMINA ss3632241769 Oct 12, 2018 (152)
68 ILLUMINA ss3633383943 Oct 12, 2018 (152)
69 ILLUMINA ss3634104895 Oct 12, 2018 (152)
70 ILLUMINA ss3635014486 Oct 12, 2018 (152)
71 ILLUMINA ss3635786747 Oct 12, 2018 (152)
72 ILLUMINA ss3636727024 Oct 12, 2018 (152)
73 ILLUMINA ss3637539385 Oct 12, 2018 (152)
74 ILLUMINA ss3638570522 Oct 12, 2018 (152)
75 ILLUMINA ss3640721780 Oct 12, 2018 (152)
76 ILLUMINA ss3641182876 Oct 12, 2018 (152)
77 ILLUMINA ss3641479822 Oct 12, 2018 (152)
78 ILLUMINA ss3643515308 Oct 12, 2018 (152)
79 ILLUMINA ss3644884154 Oct 12, 2018 (152)
80 ILLUMINA ss3653013616 Oct 12, 2018 (152)
81 ILLUMINA ss3654102476 Oct 12, 2018 (152)
82 EGCUT_WGS ss3665362471 Jul 13, 2019 (153)
83 EVA_DECODE ss3715314194 Jul 13, 2019 (153)
84 ILLUMINA ss3726255794 Jul 13, 2019 (153)
85 ACPOP ss3732642212 Jul 13, 2019 (153)
86 ILLUMINA ss3744257188 Jul 13, 2019 (153)
87 ILLUMINA ss3745314712 Jul 13, 2019 (153)
88 EVA ss3763818499 Jul 13, 2019 (153)
89 PAGE_CC ss3771220382 Jul 13, 2019 (153)
90 ILLUMINA ss3772808763 Jul 13, 2019 (153)
91 PACBIO ss3785198788 Jul 13, 2019 (153)
92 PACBIO ss3790590575 Jul 13, 2019 (153)
93 PACBIO ss3795467303 Jul 13, 2019 (153)
94 KHV_HUMAN_GENOMES ss3806989779 Jul 13, 2019 (153)
95 EVA ss3829404692 Apr 26, 2020 (154)
96 HGDP ss3847800659 Apr 26, 2020 (154)
97 SGDP_PRJ ss3862552909 Apr 26, 2020 (154)
98 KRGDB ss3909161324 Apr 26, 2020 (154)
99 KOGIC ss3957289872 Apr 26, 2020 (154)
100 EVA ss3984551562 Apr 26, 2021 (155)
101 EVA ss3985158951 Apr 26, 2021 (155)
102 EVA ss4017222154 Apr 26, 2021 (155)
103 TOPMED ss4671596286 Apr 26, 2021 (155)
104 TOMMO_GENOMICS ss5173247917 Apr 26, 2021 (155)
105 EVA ss5237376490 Apr 26, 2021 (155)
106 1000Genomes NC_000005.9 - 104208013 Oct 12, 2018 (152)
107 The Avon Longitudinal Study of Parents and Children NC_000005.9 - 104208013 Oct 12, 2018 (152)
108 Genome-wide autozygosity in Daghestan NC_000005.8 - 104235912 Apr 26, 2020 (154)
109 Genetic variation in the Estonian population NC_000005.9 - 104208013 Oct 12, 2018 (152)
110 The Danish reference pan genome NC_000005.9 - 104208013 Apr 26, 2020 (154)
111 gnomAD - Genomes NC_000005.10 - 104872312 Apr 26, 2021 (155)
112 Genome of the Netherlands Release 5 NC_000005.9 - 104208013 Apr 26, 2020 (154)
113 HGDP-CEPH-db Supplement 1 NC_000005.8 - 104235912 Apr 26, 2020 (154)
114 HapMap NC_000005.10 - 104872312 Apr 26, 2020 (154)
115 KOREAN population from KRGDB NC_000005.9 - 104208013 Apr 26, 2020 (154)
116 Korean Genome Project NC_000005.10 - 104872312 Apr 26, 2020 (154)
117 Northern Sweden NC_000005.9 - 104208013 Jul 13, 2019 (153)
118 The PAGE Study NC_000005.10 - 104872312 Jul 13, 2019 (153)
119 Ancient Sardinia genome-wide 1240k capture data generation and analysis NC_000005.9 - 104208013 Apr 26, 2021 (155)
120 CNV burdens in cranial meningiomas NC_000005.9 - 104208013 Apr 26, 2021 (155)
121 Qatari NC_000005.9 - 104208013 Apr 26, 2020 (154)
122 SGDP_PRJ NC_000005.9 - 104208013 Apr 26, 2020 (154)
123 Siberian NC_000005.9 - 104208013 Apr 26, 2020 (154)
124 8.3KJPN NC_000005.9 - 104208013 Apr 26, 2021 (155)
125 TopMed NC_000005.10 - 104872312 Apr 26, 2021 (155)
126 UK 10K study - Twins NC_000005.9 - 104208013 Oct 12, 2018 (152)
127 A Vietnamese Genetic Variation Database NC_000005.9 - 104208013 Jul 13, 2019 (153)
128 ALFA NC_000005.10 - 104872312 Apr 26, 2021 (155)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs61421303 May 26, 2008 (130)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
396950, 478551, ss84379242, ss109279595, ss112302808, ss116741695, ss162509617, ss165628690, ss200623243, ss206921928, ss253677271, ss278410556, ss293424821, ss479177865, ss1397422022, ss1591429479, ss1712786478, ss3643515308, ss3847800659 NC_000005.8:104235911:G:A NC_000005.10:104872311:G:A (self)
28052863, 15598564, 11100719, 7432413, 6933185, 16338718, 5927077, 384878, 100933, 7203786, 14569889, 3861097, 31217224, 15598564, 3461426, ss221852789, ss233070131, ss240212261, ss479179937, ss479505237, ss484389998, ss536572939, ss558589719, ss652475387, ss778346223, ss782641337, ss783610771, ss831891532, ss833800881, ss981909278, ss1072883241, ss1316402651, ss1430444008, ss1581267474, ss1613577591, ss1656571624, ss1752540217, ss1803957901, ss1925161856, ss1946151180, ss1958809339, ss2023187105, ss2151344743, ss2444716658, ss2626087528, ss2634316599, ss2706902057, ss2711044863, ss2828457036, ss2997471128, ss3022513816, ss3346536001, ss3625879565, ss3629300871, ss3632241769, ss3633383943, ss3634104895, ss3635014486, ss3635786747, ss3636727024, ss3637539385, ss3638570522, ss3640721780, ss3641182876, ss3641479822, ss3644884154, ss3653013616, ss3654102476, ss3665362471, ss3732642212, ss3744257188, ss3745314712, ss3763818499, ss3772808763, ss3785198788, ss3790590575, ss3795467303, ss3829404692, ss3862552909, ss3909161324, ss3984551562, ss3985158951, ss4017222154, ss5173247917, ss5237376490 NC_000005.9:104208012:G:A NC_000005.10:104872311:G:A (self)
198450510, 2929571, 13667873, 441851, 318249143, 508973843, 2325878975, ss2276439226, ss3025377202, ss3473335196, ss3715314194, ss3726255794, ss3771220382, ss3806989779, ss3957289872, ss4671596286 NC_000005.10:104872311:G:A NC_000005.10:104872311:G:A (self)
ss13927952, ss17861941 NT_034772.5:6623025:G:A NC_000005.10:104872311:G:A (self)
ss66941922, ss70984384, ss75391447, ss119612521, ss155827998, ss159859691, ss169622008 NT_034772.6:12521884:G:A NC_000005.10:104872311:G:A (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

1 citation for rs10074959
PMID Title Author Year Journal
23648065 Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Low SK et al. 2013 Cancer science
Help

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post596+ae089ad