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Br J Cancer. 1996 May; 73(9): 1141–1147.
PMCID: PMC2074398
PMID: 8624278

Childhood leukaemias in New Zealand: time trends and ethnic differences.

Abstract

Registrations from the New Zealand Cancer Registry were used to examine time trends in the incidence of leukaemias among children aged 0-14. There was a statistically significant increase in the incidence of leukaemia among children aged 0-4 during 1953-57 to 1988-90. In this age group, the recorded incidence rate increased from 4.89 per 100,000 person-years in 1953-57 to 7.92 in 1988-90. During 1973-77 to 1988-90 (and probably in earlier years), the increase was due to an increase in acute lymphoblastic leukaemia (ALL). The trends were unlikely to be due to changes in diagnosis or case ascertainment. The childhood leukaemia trends might be related to trends in family size, maternal age, socioeconomic level or exposure to infections. However, there are uncertainties about the importance of these factors or about their trends. The incidence of acute non-lymphoblastic leukaemia (ANLL) decreased between 1968-72 and 1988-90. The time trends highlight the likely importance of environmental factors in the aetiology of childhood leukaemias in New Zealand. The risk of ALL was lower in the Maori than in the non-Maori population (relative risk Maori/non-Maori 0.74). The risk of ANLL was higher among Maori (relative risk 1.84).

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  • Ajiki W, Hanai A, Tsukuma H, Hiyama T, Fujimoto I. Incidence of childhood cancer in Osaka, Japan, 1971-1988: reclassification of registered cases by Birch's scheme using information on clinical diagnosis, histology and primary site. Jpn J Cancer Res. 1994 Feb;85(2):139–146. [PMC free article] [PubMed]
  • Austin H, Delzell E, Cole P. Benzene and leukemia. A review of the literature and a risk assessment. Am J Epidemiol. 1988 Mar;127(3):419–439. [PubMed]
  • Birch JM, Marsden HB. A classification scheme for childhood cancer. Int J Cancer. 1987 Nov 15;40(5):620–624. [PubMed]
  • Birch JM, Marsden HB, Swindell R. Incidence of malignant disease in childhood: a 24-year review of the Manchester Children's Tumour Registry data. Br J Cancer. 1980 Aug;42(2):215–223. [PMC free article] [PubMed]
  • Birch JM, Swindell R, Marsden HB, Morris Jones PH. Childhood leukaemia in North West England 1954-1977: epidemiology, incidence and survival. Br J Cancer. 1981 Mar;43(3):324–329. [PMC free article] [PubMed]
  • Birch JM, Marsden HB, Jones PH, Pearson D, Blair V. Improvements in survival from childhood cancer: results of a population based survey over 30 years. Br Med J (Clin Res Ed) 1988 May 14;296(6633):1372–1376. [PMC free article] [PubMed]
  • Blair V, Birch JM. Patterns and temporal trends in the incidence of malignant disease in children: I. Leukaemia and lymphoma. Eur J Cancer. 1994;30A(10):1490–1498. [PubMed]
  • Breslow NE. Elementary methods of cohort analysis. Int J Epidemiol. 1984 Mar;13(1):112–115. [PubMed]
  • Breslow NE, Langholz B. Childhood cancer incidence: geographical and temporal variations. Int J Cancer. 1983 Dec 15;32(6):703–716. [PubMed]
  • Coebergh JW, van der Does-van den Berg A, van Wering ER, van Steensel-Moll HA, Valkenburg HA, van't Veer MB, Schmitz PI, van Zanen GE. Childhood leukaemia in The Netherlands, 1973-1986: temporary variation of the incidence of acute lymphocytic leukaemia in young children. Br J Cancer. 1989 Jan;59(1):100–105. [PMC free article] [PubMed]
  • Brown WM, Doll R. Leukaemia in Childhood and Young Adult Life. Br Med J. 1961 Apr 8;1(5231):981–988. [PMC free article] [PubMed]
  • Darby SC, Olsen JH, Doll R, Thakrar B, Brown PD, Storm HH, Barlow L, Langmark F, Teppo L, Tulinius H. Trends in childhood leukaemia in the Nordic countries in relation to fallout from atmospheric nuclear weapons testing. BMJ. 1992 Apr 18;304(6833):1005–1009. [PMC free article] [PubMed]
  • de Nully Brown P, Hertz H, Olsen JH, Yssing M, Scheibel E, Jensen OM. Incidence of childhood cancer in Denmark 1943-1984. Int J Epidemiol. 1989 Sep;18(3):546–555. [PubMed]
  • Draper GJ, Kroll ME, Stiller CA. Childhood cancer. Cancer Surv. 1994;19-20:493–517. [PubMed]
  • Draper GJ, Stiller CA. Intramuscular vitamin K and childhood cancer. BMJ. 1992 Sep 19;305(6855):709–711. [PMC free article] [PubMed]
  • Ekelund H, Finnström O, Gunnarskog J, Källén B, Larsson Y. Administration of vitamin K to newborn infants and childhood cancer. BMJ. 1993 Jul 10;307(6896):89–91. [PMC free article] [PubMed]
  • Ericsson JL, Karnström L, Mattsson B. Childhood cancer in Sweden, 1958-1974. I. Incidence and mortality. Acta Paediatr Scand. 1978 Jul;67(4):425–432. [PubMed]
  • Fleming AF. Possible aetiological factors in leukaemias in Africa. Leuk Res. 1988;12(1):33–43. [PubMed]
  • Golding J, Paterson M, Kinlen LJ. Factors associated with childhood cancer in a national cohort study. Br J Cancer. 1990 Aug;62(2):304–308. [PMC free article] [PubMed]
  • Golding J, Greenwood R, Birmingham K, Mott M. Childhood cancer, intramuscular vitamin K, and pethidine given during labour. BMJ. 1992 Aug 8;305(6849):341–346. [PMC free article] [PubMed]
  • Goodman MT, Yoshizawa CN, Kolonel LN. Incidence trends and ethnic patterns for childhood leukaemia in Hawaii: 1960-1984. Br J Cancer. 1989 Jul;60(1):93–97. [PMC free article] [PubMed]
  • Gordis L, Szklo M, Thompson B, Kaplan E, Tonascia JA. An apparent increase in the incidence of acute nonlymphocytic leukemia in black children. Cancer. 1981 Jun 1;47(11):2763–2768. [PubMed]
  • Greaves MF, Janossy G, Peto J, Kay H. Immunologically defined subclasses of acute lymphoblastic leukaemia in children: their relationship to presentation features and prognosis. Br J Haematol. 1981 Jun;48(2):179–197. [PubMed]
  • Greaves MF, Pegram SM, Chan LC. Collaborative group study of the epidemiology of acute lymphoblastic leukaemia subtypes: background and first report. Leuk Res. 1985;9(6):715–733. [PubMed]
  • Greaves MF. Speculations on the cause of childhood acute lymphoblastic leukemia. Leukemia. 1988 Feb;2(2):120–125. [PubMed]
  • Greaves MF, Chan LC. Is spontaneous mutation the major 'cause' of childhood acute lymphoblastic leukaemia? Br J Haematol. 1986 Sep;64(1):1–13. [PubMed]
  • HEWITT D. Some features of leukaemia mortality. Br J Prev Soc Med. 1955 Apr;9(2):81–88. [PMC free article] [PubMed]
  • Kinlen L. Evidence for an infective cause of childhood leukaemia: comparison of a Scottish new town with nuclear reprocessing sites in Britain. Lancet. 1988 Dec 10;2(8624):1323–1327. [PubMed]
  • Klebanoff MA, Read JS, Mills JL, Shiono PH. The risk of childhood cancer after neonatal exposure to vitamin K. N Engl J Med. 1993 Sep 23;329(13):905–908. [PubMed]
  • McWhirter WR, Petroeschevsky AL. Incidence trends in childhood cancer in Queensland, 1973-1988. Med J Aust. 1991 Apr 1;154(7):453–455. [PubMed]
  • Neglia JP, Robison LL. Epidemiology of the childhood acute leukemias. Pediatr Clin North Am. 1988 Aug;35(4):675–692. [PubMed]
  • Olsen JH, Hertz H, Blinkenberg K, Verder H. Vitamin K regimens and incidence of childhood cancer in Denmark. BMJ. 1994 Apr 2;308(6933):895–896. [PMC free article] [PubMed]
  • Parkin DM, Stiller CA, Draper GJ, Bieber CA. The international incidence of childhood cancer. Int J Cancer. 1988 Oct 15;42(4):511–520. [PubMed]
  • Polednak AP. Recent trends in incidence and mortality rates for leukemias, and in survival rates for childhood acute lymphocytic leukemia, in Upstate New York. Cancer. 1986 May 1;57(9):1850–1858. [PubMed]
  • Ross JA, Davies SM, Potter JD, Robison LL. Epidemiology of childhood leukemia, with a focus on infants. Epidemiol Rev. 1994;16(2):243–272. [PubMed]
  • Smith AH, Pearce NE. Determinants of differences in mortality between New Zealand Maoris and non-Maoris aged 15-64. N Z Med J. 1984 Feb 22;97(750):101–108. [PubMed]
  • Stewart A, Kneale GW. Role of local infections in the recognition of haemopoietic neoplasms. Nature. 1969 Aug 16;223(5207):741–742. [PubMed]
  • van Hoff J, Schymura MJ, Curnen MG. Trends in the incidence of childhood and adolescent cancer in Connecticut, 1935-1979. Med Pediatr Oncol. 1988;16(2):78–87. [PubMed]

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