Skip to main page content
  1. Sudhahar V, Okur MN, Bagi Z, O'Bryan JP, Hay N, Makino A, Patel VS, Phillips SA, Stepp D, Ushio-Fukai M, Fukai T. Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):529-541. doi: 10.1161/ATVBAHA.117.309819. Epub 2018 Jan 4. PubMed PMID: 29301787; PubMed Central PMCID: PMC5823760.
  2. Bagi Z. Too much TRAFfic at the crossroads of diabetes and endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2018 Jan 1;314(1):H65-H67. doi: 10.1152/ajpheart.00614.2017. Epub 2017 Nov 3. PubMed PMID: 29101184; PubMed Central PMCID: PMC5866396.
  3. Bagi Z, Brandner DD, Le P, McNeal DW, Gong X, Dou H, Fulton DJ, Beller A, Ngyuen T, Larson EB, Montine TJ, Keene CD, Back SA. Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter. Ann Neurol. 2018 Jan;83(1):142-152. doi: 10.1002/ana.25129. PubMed PMID: 29283444; PubMed Central PMCID: PMC5876126.
  4. Yao L, Bhatta A, Xu Z, Chen J, Toque HA, Chen Y, Xu Y, Bagi Z, Lucas R, Huo Y, Caldwell RB, Caldwell RW. Obesity-induced vascular inflammation involves elevated arginase activity. Am J Physiol Regul Integr Comp Physiol. 2017 Nov 1;313(5):R560-R571. doi: 10.1152/ajpregu.00529.2016. Epub 2017 Aug 23. PubMed PMID: 28835451; PubMed Central PMCID: PMC5792147.
  5. Bhatta A, Yao L, Xu Z, Toque HA, Chen J, Atawia RT, Fouda AY, Bagi Z, Lucas R, Caldwell RB, Caldwell RW. Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1. Cardiovasc Res. 2017 Nov 1;113(13):1664-1676. doi: 10.1093/cvr/cvx164. PubMed PMID: 29048462; PubMed Central PMCID: PMC6410953.
  6. Xu Y, Wang Y, Yan S, Yang Q, Zhou Y, Zeng X, Liu Z, An X, Toque HA, Dong Z, Jiang X, Fulton DJ, Weintraub NL, Li Q, Bagi Z, Hong M, Boison D, Wu C, Huo Y. Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation. Nat Commun. 2017 Oct 16;8(1):943. doi: 10.1038/s41467-017-00986-7. PubMed PMID: 29038540; PubMed Central PMCID: PMC5643397.
  7. Xu Y, Wang Y, Yan S, Zhou Y, Yang Q, Pan Y, Zeng X, An X, Liu Z, Wang L, Xu J, Cao Y, Fulton DJ, Weintraub NL, Bagi Z, Hoda MN, Wang X, Li Q, Hong M, Jiang X, Boison D, Weber C, Wu C, Huo Y. Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis. EMBO Mol Med. 2017 Sep;9(9):1263-1278. doi: 10.15252/emmm.201607066. PubMed PMID: 28751580; PubMed Central PMCID: PMC5582416.
  8. Dou H, Feher A, Davila AC, Romero MJ, Patel VS, Kamath VM, Gooz MB, Rudic RD, Lucas R, Fulton DJ, Weintraub NL, Bagi Z. Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction. Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1180-1193. doi: 10.1161/ATVBAHA.117.309430. Epub 2017 May 4. PubMed PMID: 28473444; PubMed Central PMCID: PMC5484536.
  9. Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL. A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity. J Biol Chem. 2017 Apr 14;292(15):6312-6324. doi: 10.1074/jbc.M116.758078. Epub 2017 Feb 27. PubMed PMID: 28242765; PubMed Central PMCID: PMC5391760.
  10. Virtue A, Johnson C, Lopez-Pastraña J, Shao Y, Fu H, Li X, Li YF, Yin Y, Mai J, Rizzo V, Tordoff M, Bagi Z, Shan H, Jiang X, Wang H, Yang XF. MicroRNA-155 Deficiency Leads to Decreased Atherosclerosis, Increased White Adipose Tissue Obesity, and Non-alcoholic Fatty Liver Disease: A NOVEL MOUSE MODEL OF OBESITY PARADOX. J Biol Chem. 2017 Jan 27;292(4):1267-1287. doi: 10.1074/jbc.M116.739839. Epub 2016 Nov 17. PubMed PMID: 27856635; PubMed Central PMCID: PMC5270472.
  11. Pati P, Fulton DJ, Bagi Z, Chen F, Wang Y, Kitchens J, Cassis LA, Stepp DW, Rudic RD. Low-Salt Diet and Circadian Dysfunction Synergize to Induce Angiotensin II-Dependent Hypertension in Mice. Hypertension. 2016 Mar;67(3):661-8. doi: 10.1161/HYPERTENSIONAHA.115.06194. Epub 2016 Jan 18. PubMed PMID: 26781276; PubMed Central PMCID: PMC4752410.
  12. Kovacs L, Han W, Rafikov R, Bagi Z, Offermanns S, Saido TC, Black SM, Su Y. Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 2016 Mar;54(3):384-93. doi: 10.1165/rcmb.2015-0151OC. PubMed PMID: 26248159; PubMed Central PMCID: PMC4821035.
  13. Romero MJ, Lucas R, Dou H, Sridhar S, Czikora I, Mosieri EM, Rick FG, Block NL, Sridhar S, Fulton D, Weintraub NL, Bagi Z, Schally AV. Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1895-900. doi: 10.1073/pnas.1525520113. Epub 2016 Feb 1. PubMed PMID: 26831066; PubMed Central PMCID: PMC4763773.
  14. Chen F, Haigh S, Yu Y, Benson T, Wang Y, Li X, Dou H, Bagi Z, Verin AD, Stepp DW, Csanyi G, Chadli A, Weintraub NL, Smith SM, Fulton DJ. Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones. Free Radic Biol Med. 2015 Dec;89:793-805. doi: 10.1016/j.freeradbiomed.2015.09.019. Epub 2015 Oct 9. PubMed PMID: 26456056; PubMed Central PMCID: PMC4751585.
  15. Jadeja RN, Rachakonda V, Bagi Z, Khurana S. Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography. J Vis Exp. 2015 Jul 6;(101):e50997. doi: 10.3791/50997. PubMed PMID: 26168315; PubMed Central PMCID: PMC4545206.
  16. Bagi Z. Impaired coronary collateral growth: miR-shaken neutrophils caught in the act. Am J Physiol Heart Circ Physiol. 2015 Jun 1;308(11):H1321-2. doi: 10.1152/ajpheart.00274.2015. Epub 2015 Apr 24. PubMed PMID: 25910807; PubMed Central PMCID: PMC4520577.
  17. Czikora I, Feher A, Lucas R, Fulton DJ, Bagi Z. Caveolin-1 prevents sustained angiotensin II-induced resistance artery constriction and obesity-induced high blood pressure. Am J Physiol Heart Circ Physiol. 2015 Mar 1;308(5):H376-85. doi: 10.1152/ajpheart.00649.2014. Epub 2014 Dec 19. PubMed PMID: 25527780; PubMed Central PMCID: PMC4346763.
  18. Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R. A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation. Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32. doi: 10.1164/rccm.201405-0833OC. PubMed PMID: 25029038; PubMed Central PMCID: PMC4214088.
  19. Chen F, Barman S, Yu Y, Haigh S, Wang Y, Black SM, Rafikov R, Dou H, Bagi Z, Han W, Su Y, Fulton DJ. Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species. Free Radic Biol Med. 2014 Aug;73:201-13. doi: 10.1016/j.freeradbiomed.2014.04.029. Epub 2014 May 14. PubMed PMID: 24835767; PubMed Central PMCID: PMC4228786.
  20. Feher A, Broskova Z, Bagi Z. Age-related impairment of conducted dilation in human coronary arterioles. Am J Physiol Heart Circ Physiol. 2014 Jun 15;306(12):H1595-601. doi: 10.1152/ajpheart.00179.2014. Epub 2014 Apr 28. PubMed PMID: 24778172; PubMed Central PMCID: PMC4059982.
  21. Bagi Z, Broskova Z, Feher A. Obesity and coronary microvascular disease - implications for adipose tissue-mediated remote inflammatory response. Curr Vasc Pharmacol. 2014 May;12(3):453-61. Review. PubMed PMID: 24846234; PubMed Central PMCID: PMC4167722.
  22. Cassuto J, Dou H, Czikora I, Szabo A, Patel VS, Kamath V, Belin de Chantemele E, Feher A, Romero MJ, Bagi Z. Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients. Diabetes. 2014 Apr;63(4):1381-93. doi: 10.2337/db13-0577. Epub 2013 Dec 18. PubMed PMID: 24353182; PubMed Central PMCID: PMC3964507.
  23. Feher A, Chen SY, Bagi Z, Arora V. Prevention and treatment of no-reflow phenomenon by targeting the coronary microcirculation. Rev Cardiovasc Med. 2014;15(1):38-51. Review. PubMed PMID: 24762465.
  24. Romero MJ, Yao L, Sridhar S, Bhatta A, Dou H, Ramesh G, Brands MW, Pollock DM, Caldwell RB, Cederbaum SD, Head CA, Bagi Z, Lucas R, Caldwell RW. l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice. Front Immunol. 2013;4:480. doi: 10.3389/fimmu.2013.00480. eCollection 2013. PubMed PMID: 24400007; PubMed Central PMCID: PMC3871963.
  25. Bagi Z, Feher A, Dou H, Broskova Z. Selective up-regulation of arginase-1 in coronary arteries of diabetic patients. Front Immunol. 2013 Sep 26;4:293. doi: 10.3389/fimmu.2013.00293. Review. PubMed PMID: 24133491; PubMed Central PMCID: PMC3783852.
  26. Broskova Z, Sotnikova R, Nedelcevova J, Bagi Z. Effect of a novel stobadine derivative on isolated rat arteries. Interdiscip Toxicol. 2013 Jun;6(2):63-6. doi: 10.2478/intox-2013-0011. PubMed PMID: 24179430; PubMed Central PMCID: PMC3798857.
  27. Cassuto J, Feher A, Lan L, Patel VS, Kamath V, Anthony DC, Bagi Z. Obesity and statins are both independent predictors of enhanced coronary arteriolar dilation in patients undergoing heart surgery. J Cardiothorac Surg. 2013 Apr 30;8:117. doi: 10.1186/1749-8090-8-117. PubMed PMID: 23631400; PubMed Central PMCID: PMC3658876.
  28. Feher A, Cassuto J, Szabo A, Patel V, Vinayak Kamath M, Bagi Z. Increased tissue angiotensin-converting enzyme activity impairs bradykinin-induced dilation of coronary arterioles in obesity. Circ J. 2013;77(7):1867-76. Epub 2013 Apr 20. PubMed PMID: 23603844; PubMed Central PMCID: PMC3696050.
  29. Koller A, Balasko M, Bagi Z. Endothelial regulation of coronary microcirculation in health and cardiometabolic diseases. Intern Emerg Med. 2013 Apr;8 Suppl 1:S51-4. doi: 10.1007/s11739-013-0910-5. Review. PubMed PMID: 23494539; PubMed Central PMCID: PMC3676666.
  30. Gödény I, Pollesello P, Edes I, Papp Z, Bagi Z. Levosimendan and its metabolite OR-1896 elicit KATP channel-dependent dilation in resistance arteries in vivo. Pharmacol Rep. 2013;65(5):1304-10. PubMed PMID: 24399726; PubMed Central PMCID: PMC4016981.
  31. Huang A, Yang YM, Feher A, Bagi Z, Kaley G, Sun D. Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 15;302(6):R674-81. doi: 10.1152/ajpregu.00699.2011. Epub 2012 Jan 18. PubMed PMID: 22262308; PubMed Central PMCID: PMC3774487.
  32. Beleznai T, Bagi Z. Activation of hexosamine pathway impairs nitric oxide (NO)-dependent arteriolar dilations by increased protein O-GlcNAcylation. Vascul Pharmacol. 2012 Mar-Apr;56(3-4):115-21. doi: 10.1016/j.vph.2011.11.003. Epub 2011 Dec 3. PubMed PMID: 22155161; PubMed Central PMCID: PMC3351206.
  33. Bagi Z, Feher A, Cassuto J. Microvascular responsiveness in obesity: implications for therapeutic intervention. Br J Pharmacol. 2012 Feb;165(3):544-60. doi: 10.1111/j.1476-5381.2011.01606.x. Review. PubMed PMID: 21797844; PubMed Central PMCID: PMC3315030.
  34. Jefferson A, Wijesurendra RS, McAteer MA, Digby JE, Douglas G, Bannister T, Perez-Balderas F, Bagi Z, Lindsay AC, Choudhury RP. Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: rational design through target quantification. Atherosclerosis. 2011 Dec;219(2):579-87. doi: 10.1016/j.atherosclerosis.2011.07.127. Epub 2011 Aug 5. PubMed PMID: 21872249; PubMed Central PMCID: PMC3234340.
  35. Bagi Z, Feher A, Cassuto J, Akula K, Labinskyy N, Kaley G, Koller A. Increased availability of angiotensin AT 1 receptors leads to sustained arterial constriction to angiotensin II in diabetes - role for Rho-kinase activation. Br J Pharmacol. 2011 Jul;163(5):1059-68. doi: 10.1111/j.1476-5381.2011.01307.x. PubMed PMID: 21385178; PubMed Central PMCID: PMC3130951.
  36. Beleznai T, Feher A, Spielvogel D, Lansman SL, Bagi Z. Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes. Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H777-83. doi: 10.1152/ajpheart.00831.2010. Epub 2011 Jan 7. PubMed PMID: 21217072; PubMed Central PMCID: PMC3064303.
  37. Feher A, Rutkai I, Beleznai T, Ungvari Z, Csiszar A, Edes I, Bagi Z. Caveolin-1 limits the contribution of BK(Ca) channel to EDHF-mediated arteriolar dilation: implications in diet-induced obesity. Cardiovasc Res. 2010 Sep 1;87(4):732-9. doi: 10.1093/cvr/cvq088. Epub 2010 Mar 17. PubMed PMID: 20299334; PubMed Central PMCID: PMC2920808.
  38. Prieto D, Kaminski PM, Bagi Z, Ahmad M, Wolin MS. Hypoxic relaxation of penile arteries: involvement of endothelial nitric oxide and modulation by reactive oxygen species. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H915-24. doi: 10.1152/ajpheart.00382.2010. Epub 2010 Jun 25. PubMed PMID: 20581086; PubMed Central PMCID: PMC2944490.
  39. Ungvari Z, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson K, de Cabo R, Csiszar A. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H18-24. doi: 10.1152/ajpheart.00260.2010. Epub 2010 Apr 23. PubMed PMID: 20418481; PubMed Central PMCID: PMC2904129.
  40. Retailleau K, Belin de Chantemèle EJ, Chanoine S, Guihot AL, Vessières E, Toutain B, Faure S, Bagi Z, Loufrani L, Henrion D. Reactive oxygen species and cyclooxygenase 2-derived thromboxane A2 reduce angiotensin II type 2 receptor vasorelaxation in diabetic rat resistance arteries. Hypertension. 2010 Feb;55(2):339-44. doi: 10.1161/HYPERTENSIONAHA.109.140236. Epub 2009 Dec 21. PubMed PMID: 20026767.
  41. Racz A, Veresh Z, Lotz G, Bagi Z, Koller A. Cyclooxygenase-2 derived thromboxane A(2) and reactive oxygen species mediate flow-induced constrictions of venules in hyperhomocysteinemia. Atherosclerosis. 2010 Jan;208(1):43-9. doi: 10.1016/j.atherosclerosis.2009.06.014. Epub 2009 Jun 18. PubMed PMID: 19615686.
  42. Ungvari Z, Labinskyy N, Mukhopadhyay P, Pinto JT, Bagi Z, Ballabh P, Zhang C, Pacher P, Csiszar A. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1876-81. doi: 10.1152/ajpheart.00375.2009. Epub 2009 Sep 11. PubMed PMID: 19749157; PubMed Central PMCID: PMC2781360.
  43. Bagi Z. Mechanisms of coronary microvascular adaptation to obesity. Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R556-67. doi: 10.1152/ajpregu.90817.2008. Epub 2009 Jun 17. Review. PubMed PMID: 19535672.
  44. Rutkai I, Feher A, Erdei N, Henrion D, Papp Z, Edes I, Koller A, Kaley G, Bagi Z. Activation of prostaglandin E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes. Cardiovasc Res. 2009 Jul 1;83(1):148-54. doi: 10.1093/cvr/cvp098. Epub 2009 Mar 19. PubMed PMID: 19299433; PubMed Central PMCID: PMC2695704.
  45. Bagi Z, Kaley G. Where have all the stem cells gone?. Circ Res. 2009 Feb 13;104(3):280-1. doi: 10.1161/CIRCRESAHA.108.192641. PubMed PMID: 19213961; PubMed Central PMCID: PMC2751582.
  46. Racz A, Veresh Z, Erdei N, Bagi Z, Koller A. Thromboxane A(2) contributes to the mediation of flow-induced responses of skeletal muscle venules: role of cyclooxygenases 1 and 2. J Vasc Res. 2009;46(5):397-405. doi: 10.1159/000194270. Epub 2009 Jan 21. PubMed PMID: 19155631; PubMed Central PMCID: PMC2790754.
  47. Bagi Z, Feher A, Beleznai T. Preserved coronary arteriolar dilatation in patients with type 2 diabetes mellitus: implications for reactive oxygen species. Pharmacol Rep. 2009 Jan-Feb;61(1):99-104. Review. PubMed PMID: 19307697.
  48. Bagi Z, Erdei N, Koller A. High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors. Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H835-41. doi: 10.1152/ajpheart.00205.2008. Epub 2008 Jun 20. PubMed PMID: 18567710; PubMed Central PMCID: PMC2519219.
  49. Jebelovszki E, Kiraly C, Erdei N, Feher A, Pasztor ET, Rutkai I, Forster T, Edes I, Koller A, Bagi Z. High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2558-64. doi: 10.1152/ajpheart.01198.2007. Epub 2008 Apr 11. PubMed PMID: 18408126.
  50. Kark T, Bagi Z, Lizanecz E, Pásztor ET, Erdei N, Czikora A, Papp Z, Edes I, Pórszász R, Tóth A. Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1. Mol Pharmacol. 2008 May;73(5):1405-12. doi: 10.1124/mol.107.043323. Epub 2008 Feb 6. PubMed PMID: 18256211.