My Bibliography

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Gallitto M, Zhang X, De Los Santos G, Wei HJ, Fernández EC, Duan S, Sedor G, Yoh N, Kokossis D, Angel JC, Wang YF, White E, Kinslow CJ, Berg X, Tomassoni L, Zandkarimi F, Chio IIC, Canoll P, Bruce JN, Feldstein NA, Gartrell RD, Cheng SK, Garvin JH, Zacharoulis S, Wechsler-Reya RJ, Pavisic J, Califano A, Zhang Z, Wu CC. Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma. Neuro Oncol. 2025 Mar 7;27(3):795-810. doi: 10.1093/neuonc/noae215. PubMed PMID: 39394920; PubMed Central PMCID: PMC11889722.

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Dunbar KJ, Efe G, Cunningham K, Esquea E, Navaridas R, Rustgi AK. Regulation of metastatic organotropism. Trends Cancer. 2025 Mar;11(3):216-231. doi: 10.1016/j.trecan.2024.11.012. Epub 2024 Dec 27. Review. PubMed PMID: 39732596; PubMed Central PMCID: PMC11903188.

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Li Z, Zhang Z. A tale of two strands: Decoding chromatin replication through strand-specific sequencing. Mol Cell. 2025 Jan 16;85(2):238-261. doi: 10.1016/j.molcel.2024.10.035. Epub 2025 Jan 16. Review. PubMed PMID: 39824166; PubMed Central PMCID: PMC11750172.

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Kimble MT, Sane A, Reid RJD, Johnson MJ, Rothstein R, Symington LS. Repair of replication-dependent double-strand breaks differs between the leading and lagging strands. Mol Cell. 2025 Jan 2;85(1):61-77.e6. doi: 10.1016/j.molcel.2024.10.032. Epub 2024 Dec 3. PubMed PMID: 39631395; PubMed Central PMCID: PMC11698654.

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Duan S, Nodelman IM, Zhou H, Tsukiyama T, Bowman GD, Zhang Z. H3K56 acetylation regulates chromatin maturation following DNA replication. Nat Commun. 2025 Jan 2;16(1):134. doi: 10.1038/s41467-024-55144-7. PubMed PMID: 39746969; PubMed Central PMCID: PMC11697131.

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Triplett MK, Johnson MJ, Symington LS. Induction of homologous recombination by site-specific replication stress. DNA Repair (Amst). 2024 Oct;142:103753. doi: 10.1016/j.dnarep.2024.103753. Epub 2024 Aug 16. Review. PubMed PMID: 39190984; PubMed Central PMCID: PMC11425181.

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Toda T, Fang Y, Shan CM, Hua X, Kim JK, Tang LC, Jovanovic M, Tong L, Qiao F, Zhang Z, Jia S. Mrc1 regulates parental histone segregation and heterochromatin inheritance. Mol Cell. 2024 Sep 5;84(17):3223-3236.e4. doi: 10.1016/j.molcel.2024.07.002. Epub 2024 Aug 1. PubMed PMID: 39094566; PubMed Central PMCID: PMC11414769.

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Yu J, Zhang Y, Fang Y, Paulo JA, Yaghoubi D, Hua X, Shipkovenska G, Toda T, Zhang Z, Gygi SP, Jia S, Li Q, Moazed D. A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance. Cell. 2024 Sep 5;187(18):5010-5028.e24. doi: 10.1016/j.cell.2024.07.006. Epub 2024 Aug 1. PubMed PMID: 39094570; PubMed Central PMCID: PMC11380579.

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Zhang X, Duan S, Apostolou PE, Wu X, Watanabe J, Gallitto M, Barron T, Taylor KR, Woo PJ, Hua X, Zhou H, Wei HJ, McQuillan N, Kang KD, Friedman GK, Canoll PD, Chang K, Wu CC, Hashizume R, Vakoc CR, Monje M, McKhann GM 2nd, Gogos JA, Zhang Z. CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma. Cancer Discov. 2024 Sep 4;14(9):1732-1754. doi: 10.1158/2159-8290.CD-23-0012. PubMed PMID: 38767413; PubMed Central PMCID: PMC11456263.

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Hua X, Zhou H, Wu HC, Furnari J, Kotidis CP, Rabadan R, Genkinger JM, Bruce JN, Canoll P, Santella RM, Zhang Z. Tumor detection by analysis of both symmetric- and hemi-methylation of plasma cell-free DNA. Nat Commun. 2024 Jul 20;15(1):6113. doi: 10.1038/s41467-024-50471-1. PubMed PMID: 39030196; PubMed Central PMCID: PMC11271492.

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Padilla O, Minns HE, Wei HJ, Fan W, Webster-Carrion A, Tazhibi M, McQuillan NM, Zhang X, Gallitto M, Yeh R, Zhang Z, Hei TK, Szalontay L, Pavisic J, Tan Y, Deoli N, Garty G, Garvin JH, Canoll PD, Vanpouille-Box C, Menon V, Olah M, Rabadan R, Wu CC, Gartrell RD. Immune Response following FLASH and Conventional Radiation in Diffuse Midline Glioma. Int J Radiat Oncol Biol Phys. 2024 Jul 15;119(4):1248-1260. doi: 10.1016/j.ijrobp.2024.01.219. Epub 2024 Feb 15. PubMed PMID: 38364947; PubMed Central PMCID: PMC11209798.

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Serra-Cardona A, Hua X, McNutt SW, Zhou H, Toda T, Jia S, Chu F, Zhang Z. The PCNA-Pol δ complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance. Sci Adv. 2024 Jun 7;10(23):eadn5175. doi: 10.1126/sciadv.adn5175. Epub 2024 Jun 5. PubMed PMID: 38838138; PubMed Central PMCID: PMC11152121.

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Gan S, Yang WS, Wei L, Zhang Z, Xu RM. Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2. Sci China Life Sci. 2024 Jun;67(6):1305-1307. doi: 10.1007/s11427-024-2560-8. Epub 2024 Mar 7. PubMed PMID: 38478295; PubMed Central PMCID: PMC11156535.

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Watanabe J, Clutter MR, Gullette MJ, Sasaki T, Uchida E, Kaur S, Mo Y, Abe K, Ishi Y, Takata N, Natsumeda M, Gadd S, Zhang Z, Becher OJ, Hashizume R. BET bromodomain inhibition potentiates radiosensitivity in models of H3K27-altered diffuse midline glioma. J Clin Invest. 2024 May 21;134(13). doi: 10.1172/JCI174794. PubMed PMID: 38771655; PubMed Central PMCID: PMC11213469.

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Tazhibi M, McQuillan N, Wei HJ, Gallitto M, Bendau E, Webster Carrion A, Berg X, Kokossis D, Zhang X, Zhang Z, Jan CI, Mintz A, Gartrell RD, Syed HR, Fonseca A, Pavisic J, Szalontay L, Konofagou EE, Zacharoulis S, Wu CC. Focused ultrasound-mediated blood-brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma. J Transl Med. 2024 Mar 30;22(1):320. doi: 10.1186/s12967-024-05096-9. PubMed PMID: 38555449; PubMed Central PMCID: PMC10981822.

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Fang Y, Hua X, Shan CM, Toda T, Qiao F, Zhang Z, Jia S. Coordination of histone chaperones for parental histone segregation and epigenetic inheritance. Genes Dev. 2024 Mar 22;38(3-4):189-204. doi: 10.1101/gad.351278.123. PubMed PMID: 38479839; PubMed Central PMCID: PMC10982699.

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Wang Z, Yang X, Chen D, Liu Y, Li Z, Duan S, Zhang Z, Jiang X, Stockwell BR, Gu W. GAS41 modulates ferroptosis by anchoring NRF2 on chromatin. Nat Commun. 2024 Mar 21;15(1):2531. doi: 10.1038/s41467-024-46857-w. PubMed PMID: 38514704; PubMed Central PMCID: PMC10957913.

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Flashner S, Shimonosono M, Tomita Y, Matsuura N, Ohashi S, Muto M, Klein-Szanto AJ, Alan Diehl J, Chen CH, Mochly-Rosen D, Weinberg KI, Nakagawa H. ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment. Carcinogenesis. 2024 Feb 12;45(1-2):95-106. doi: 10.1093/carcin/bgad085. PubMed PMID: 37978873; PubMed Central PMCID: PMC10859731.

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Yang X, Duan S, Li Z, Wang Z, Kon N, Zhang Z, Gu W. Protocol of CRISPR-Cas9 knockout screens for identifying ferroptosis regulators. STAR Protoc. 2023 Dec 15;4(4):102762. doi: 10.1016/j.xpro.2023.102762. Epub 2023 Dec 3. PubMed PMID: 38048220; PubMed Central PMCID: PMC10730373.

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Leeman-Neill RJ, Song D, Bizarro J, Wacheul L, Rothschild G, Singh S, Yang Y, Sarode AY, Gollapalli K, Wu L, Zhang W, Chen Y, Lauring MC, Whisenant DE, Bhavsar S, Lim J, Swerdlow SH, Bhagat G, Zhao Q, Berchowitz LE, Lafontaine DLJ, Wang J, Basu U. Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression. Nat Genet. 2023 Dec;55(12):2160-2174. doi: 10.1038/s41588-023-01561-1. Epub 2023 Dec 4. PubMed PMID: 38049665; PubMed Central PMCID: PMC10703697.

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Li Z, Duan S, Hua X, Xu X, Li Y, Menolfi D, Zhou H, Lu C, Zha S, Goff SP, Zhang Z. Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements. Nature. 2023 Nov;623(7987):643-651. doi: 10.1038/s41586-023-06711-3. Epub 2023 Nov 8. PubMed PMID: 37938774; PubMed Central PMCID: PMC11034792.

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Liu CP, Yu Z, Xiong J, Hu J, Song A, Ding D, Yu C, Yang N, Wang M, Yu J, Hou P, Zeng K, Li Z, Zhang Z, Zhang X, Li W, Zhang Z, Zhu B, Li G, Xu RM. Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science. 2023 Aug 25;381(6660):eadd8673. doi: 10.1126/science.add8673. Epub 2023 Aug 25. PubMed PMID: 37616371; PubMed Central PMCID: PMC11186048.

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Yang X, Wang Z, Zandkarimi F, Liu Y, Duan S, Li Z, Kon N, Zhang Z, Jiang X, Stockwell BR, Gu W. Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism. Cell Metab. 2023 Aug 8;35(8):1474-1490.e8. doi: 10.1016/j.cmet.2023.06.014. Epub 2023 Jul 18. PubMed PMID: 37467745; PubMed Central PMCID: PMC10529626.

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Kimble MT, Johnson MJ, Nester MR, Symington LS. Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation. Elife. 2023 Jun 30;12. doi: 10.7554/eLife.84322. PubMed PMID: 37387287; PubMed Central PMCID: PMC10400078.

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Li Z, Zhang Z. Histone chaperones: A multinodal highway network inside the cell. Mol Cell. 2023 Apr 6;83(7):1024-1026. doi: 10.1016/j.molcel.2023.03.004. PubMed PMID: 37028413; PubMed Central PMCID: PMC10332477.

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Su Z, Kon N, Yi J, Zhao H, Zhang W, Tang Q, Li H, Kobayashi H, Li Z, Duan S, Liu Y, Olive KP, Zhang Z, Honig B, Manfredi JJ, Rustgi AK, Gu W. Specific regulation of BACH1 by the hotspot mutant p53(R175H) reveals a distinct gain-of-function mechanism. Nat Cancer. 2023 Apr;4(4):564-581. doi: 10.1038/s43018-023-00532-z. Epub 2023 Mar 27. PubMed PMID: 36973430; PubMed Central PMCID: PMC10320414.

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Gallitto M, Zhang Z. The evolving tale of Pol2 function. Genes Dev. 2023 Feb 1;37(3-4):72-73. doi: 10.1101/gad.350527.123. Epub 2023 Feb 22. Review. PubMed PMID: 36813532; PubMed Central PMCID: PMC10069447.

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Mo Y, Duan S, Zhang X, Hua X, Zhou H, Wei HJ, Watanabe J, McQuillan N, Su Z, Gu W, Wu CC, Vakoc CR, Hashizume R, Chang K, Zhang Z. Epigenome Programming by H3.3K27M Mutation Creates a Dependence of Pediatric Glioma on SMARCA4. Cancer Discov. 2022 Dec 2;12(12):2906-2929. doi: 10.1158/2159-8290.CD-21-1492. PubMed PMID: 36305747; PubMed Central PMCID: PMC9722525.

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Xu X, Hua X, Brown K, Ren X, Zhang Z. Mcm2 promotes stem cell differentiation via its ability to bind H3-H4. Elife. 2022 Nov 10;11. doi: 10.7554/eLife.80917. PubMed PMID: 36354740; PubMed Central PMCID: PMC9681210.

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Du W, Shi G, Shan CM, Li Z, Zhu B, Jia S, Li Q, Zhang Z. Mechanisms of chromatin-based epigenetic inheritance. Sci China Life Sci. 2022 Nov;65(11):2162-2190. doi: 10.1007/s11427-022-2120-1. Epub 2022 Jun 30. Review. PubMed PMID: 35792957; PubMed Central PMCID: PMC10311375.

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Li Y, Goldberg EM, Chen X, Xu X, McGuire JT, Leuzzi G, Karagiannis D, Tate T, Farhangdoost N, Horth C, Dai E, Li Z, Zhang Z, Izar B, Que J, Ciccia A, Majewski J, Yoon AJ, Ailles L, Mendelsohn CL, Lu C. Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas. Mol Cell. 2022 Oct 20;82(20):3901-3918.e7. doi: 10.1016/j.molcel.2022.09.007. Epub 2022 Oct 6. PubMed PMID: 36206767; PubMed Central PMCID: PMC9588679.

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He R, Zhang Z. Rad53 arrests leading and lagging strand DNA synthesis via distinct mechanisms in response to DNA replication stress. Bioessays. 2022 Sep;44(9):e2200061. doi: 10.1002/bies.202200061. Epub 2022 Jul 1. PubMed PMID: 35778827; PubMed Central PMCID: PMC10316031.

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Serra-Cardona A, Duan S, Yu C, Zhang Z. H3K4me3 recognition by the COMPASS complex facilitates the restoration of this histone mark following DNA replication. Sci Adv. 2022 May 6;8(18):eabm6246. doi: 10.1126/sciadv.abm6246. Epub 2022 May 6. PubMed PMID: 35544640; PubMed Central PMCID: PMC9075808.

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Xu X, Duan S, Hua X, Li Z, He R, Zhang Z. Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions. Nat Commun. 2022 May 6;13(1):2514. doi: 10.1038/s41467-022-30298-4. PubMed PMID: 35523900; PubMed Central PMCID: PMC9076889.

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Kang TZE, Wan YCE, Zhang Z, Chan KM. Lrwd1 impacts cell proliferation and the silencing of repetitive DNA elements. Genesis. 2022 May;60(4-5):e23475. doi: 10.1002/dvg.23475. Epub 2022 Apr 22. PubMed PMID: 35451548; PubMed Central PMCID: PMC9233303.

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Evrin C, Serra-Cardona A, Duan S, Mukherjee PP, Zhang Z, Labib KPM. Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II. EMBO J. 2022 Mar 1;41(5):e109783. doi: 10.15252/embj.2021109783. Epub 2022 Feb 1. PubMed PMID: 35102600; PubMed Central PMCID: PMC8886531.

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Yang X, Wang X, Li Z, Duan S, Li H, Jin J, Zhang Z, Gu W. An unexpected role for Dicer as a reader of the unacetylated DNA binding domain of p53 in transcriptional regulation. Sci Adv. 2021 Oct 29;7(44):eabi6684. doi: 10.1126/sciadv.abi6684. Epub 2021 Oct 27. PubMed PMID: 34705508; PubMed Central PMCID: PMC8550248.

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Serra-Cardona A, Yu C, Zhang X, Hua X, Yao Y, Zhou J, Gan H, Zhang Z. A mechanism for Rad53 to couple leading- and lagging-strand DNA synthesis under replication stress in budding yeast. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38). doi: 10.1073/pnas.2109334118. PubMed PMID: 34531325; PubMed Central PMCID: PMC8463864.

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Wei HJ, Upadhyayula PS, Pouliopoulos AN, Englander ZK, Zhang X, Jan CI, Guo J, Mela A, Zhang Z, Wang TJC, Bruce JN, Canoll PD, Feldstein NA, Zacharoulis S, Konofagou EE, Wu CC. Focused Ultrasound-Mediated Blood-Brain Barrier Opening Increases Delivery and Efficacy of Etoposide for Glioblastoma Treatment. Int J Radiat Oncol Biol Phys. 2021 Jun 1;110(2):539-550. doi: 10.1016/j.ijrobp.2020.12.019. Epub 2020 Dec 17. PubMed PMID: 33346092; PubMed Central PMCID: PMC8553628.

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Shan CM, Kim JK, Wang J, Bao K, Sun Y, Chen H, Yue JX, Stirpe A, Zhang Z, Lu C, Schalch T, Liti G, Nagy PL, Tong L, Qiao F, Jia S. The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin. Cell Rep. 2021 May 18;35(7):109137. doi: 10.1016/j.celrep.2021.109137. PubMed PMID: 34010645; PubMed Central PMCID: PMC8167812.

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Li Z, Hua X, Serra-Cardona A, Xu X, Zhang Z. Efficient and strand-specific profiling of replicating chromatin with enrichment and sequencing of protein-associated nascent DNA in mammalian cells. Nat Protoc. 2021 May;16(5):2698-2721. doi: 10.1038/s41596-021-00520-6. Epub 2021 Apr 28. PubMed PMID: 33911256; PubMed Central PMCID: PMC9261918.

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Li Z, Hua X, Serra-Cardona A, Xu X, Gan S, Zhou H, Yang WS, Chen CL, Xu RM, Zhang Z. DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands. Sci Adv. 2020 Aug;6(35):eabb5820. doi: 10.1126/sciadv.abb5820. eCollection 2020 Aug. PubMed PMID: 32923642; PubMed Central PMCID: PMC7449674.

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Cheng L, Zhang X, Wang Y, Gan H, Xu X, Lv X, Hua X, Que J, Ordog T, Zhang Z. Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit. Nucleic Acids Res. 2019 Dec 2;47(21):11114-11131. doi: 10.1093/nar/gkz858. PubMed PMID: 31586391; PubMed Central PMCID: PMC6868363.

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Zhang X, Zhang Z. Oncohistone Mutations in Diffuse Intrinsic Pontine Glioma. Trends Cancer. 2019 Dec;5(12):799-808. doi: 10.1016/j.trecan.2019.10.009. Epub 2019 Nov 9. Review. PubMed PMID: 31813457; PubMed Central PMCID: PMC6986369.

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Lee JS, Mo Y, Gan H, Burgess RJ, Baker DJ, van Deursen JM, Zhang Z. Pak2 kinase promotes cellular senescence and organismal aging. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13311-13319. doi: 10.1073/pnas.1903847116. Epub 2019 Jun 17. PubMed PMID: 31209047; PubMed Central PMCID: PMC6613284.

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Zhong J, Ye Z, Clark CR, Lenz SW, Nguyen JH, Yan H, Robertson KD, Farrugia G, Zhang Z, Ordog T, Lee JH. Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq. BMC Genomics. 2019 Mar 29;20(1):249. doi: 10.1186/s12864-019-5639-8. PubMed PMID: 30922218; PubMed Central PMCID: PMC6440302.

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Li Q, Zhang X, Zhang Z. CHAF1B Overexpression: A Brake for the Differentiation of Leukemia Cells. Cancer Cell. 2018 Nov 12;34(5):693-694. doi: 10.1016/j.ccell.2018.10.011. PubMed PMID: 30423290; PubMed Central PMCID: PMC6615053.

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Gan H, Serra-Cardona A, Hua X, Zhou H, Labib K, Yu C, Zhang Z. The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands. Mol Cell. 2018 Oct 4;72(1):140-151.e3. doi: 10.1016/j.molcel.2018.09.001. Epub 2018 Sep 20. PubMed PMID: 30244834; PubMed Central PMCID: PMC6193272.

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Yu C, Gan H, Serra-Cardona A, Zhang L, Gan S, Sharma S, Johansson E, Chabes A, Xu RM, Zhang Z. A mechanism for preventing asymmetric histone segregation onto replicating DNA strands. Science. 2018 Sep 28;361(6409):1386-1389. doi: 10.1126/science.aat8849. Epub 2018 Aug 16. PubMed PMID: 30115745; PubMed Central PMCID: PMC6597248.

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Zhang L, Serra-Cardona A, Zhou H, Wang M, Yang N, Zhang Z, Xu RM. Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109. Cell. 2018 Aug 9;174(4):818-830.e11. doi: 10.1016/j.cell.2018.07.005. Epub 2018 Jul 26. PubMed PMID: 30057113; PubMed Central PMCID: PMC6103222.