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Mol Ther.
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Homeostatic regulation of nucleoporins is a central driver of nuclear pore biogenesis.
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Structural basis for substrate binding, catalysis, and inhibition of cancer target mitochondrial creatine kinase by a covalent inhibitor.
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Three STEPs forward: A trio of unexpected structures of PTPN5.
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Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase.
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Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSCs-derived myogenic progenitor cells.
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Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer.
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Mitochondrial metabolism and epigenetic crosstalk drive the SASP.
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Tenascin-C from the tissue microenvironment promotes muscle stem cell self-renewal through Annexin A2.
bioRxiv.
2024 Nov 1;. doi: 10.1101/2024.10.29.620732. PubMed PMID:
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Overcoming artificial structures in resolution-enhanced Hi-C data by signal decomposition and multi-scale attention.
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2024 Oct 24;. doi: 10.1101/2024.10.21.619560. PubMed PMID:
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Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression.
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Linked regulation of genome integrity and senescence-associated inflammation by p53.
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2024 Sep 19;. doi: 10.1101/2023.11.20.567963. PubMed PMID:
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Structural basis of human 20S proteasome biogenesis.
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Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.
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STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells.
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Integrative genomic reconstruction of carbohydrate utilization networks in bifidobacteria: global trends, local variability, and dietary adaptation.
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METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence.
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Structural Basis for Substrate Binding, Catalysis and Inhibition of Breast Cancer Target Mitochondrial Creatine Kinase by Covalent Inhibitor via Cryo-EM.
bioRxiv.
2024 Jun 18;. doi: 10.1101/2024.06.18.598884. PubMed PMID:
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Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.
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Image-based assessment of natural killer cell activity against glioblastoma stem cells.
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PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors.
Nat Cancer.
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ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC.
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Genome Biol.
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Transcriptional control of leukemogenesis by the chromatin reader SGF29.
Blood.
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Autophagy protein ATG-16.2 and its WD40 domain mediate the beneficial effects of inhibiting early-acting autophagy genes in C. elegans neurons.
Nat Aging.
2024 Feb;4(2):198-212. doi: 10.1038/s43587-023-00548-1. Epub 2024 Jan 4. PubMed PMID:
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Detection of Genomic Structural Variations Associated with Drug Sensitivity and Resistance in Acute Leukemia.
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RNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential.
Mol Cancer Res.
2024 Jan 2;22(1):41-54. doi: 10.1158/1541-7786.MCR-23-0512. PubMed PMID:
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Inferring secretory and metabolic pathway activity from omic data with secCellFie.
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2024 Jan;81:273-285. doi: 10.1016/j.ymben.2023.12.006. Epub 2023 Dec 23. PubMed PMID:
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Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma.
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miRNA-211 maintains metabolic homeostasis in medulloblastoma through its target gene long-chain acyl-CoA synthetase 4.
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Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.
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Enzyme mechanistic studies of NMA1982, a protein tyrosine phosphatase and potential virulence factor in Neisseria meningitidis.
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Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma.
Nat Genet.
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Imaging-based chromatin and epigenetic age, ImAge, quantitates aging and rejuvenation.
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Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention.
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Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis.
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TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity.
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2023 Sep;299(9):105120. doi: 10.1016/j.jbc.2023.105120. Epub 2023 Jul 30. PubMed PMID:
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Metabolic programs of T cell tissue residency empower tumour immunity.
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Post-translational modifications of ATG8 proteins - an emerging mechanism of autophagy control.
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Asparagine restriction enhances CD8(+) T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response.
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Dynamic Nuclear Polarization Illuminates Key Protein-Lipid Interactions in the Native Bacterial Cell Envelope.
Biochemistry.
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