My Bibliography

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PMID: 33999437. Hepatology (Baltimore, Md.). . NIHMSID: NIHMS1771005.

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PMID: 33999437. Hepatology (Baltimore, Md.). . NIHMSID: NIHMS2086137.

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Zhai Y, Kupiec-Weglinski JW. What is the role of regulatory T cells in transplantation tolerance?. Curr Opin Immunol. 1999 Oct;11(5):497-503. doi: 10.1016/s0952-7915(99)00007-2. Review. PubMed PMID: 10508706.

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Zhai Y, Ghobrial RM, Busuttil RW, Kupiec-Weglinski JW. Th1 and Th2 cytokines in organ transplantation: paradigm lost?. Crit Rev Immunol. 1999;19(2):155-72. Review. PubMed PMID: 10352902.

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Ke B, Coito AJ, Kato H, Zhai Y, Wang T, Sawitzki B, Seu P, Busuttil RW, Kupiec-Weglinski JW. Fas ligand gene transfer prolongs rat renal allograft survival and down-regulates anti-apoptotic Bag-1 in parallel with enhanced Th2-type cytokine expression. Transplantation. 2000 Apr 27;69(8):1690-4. doi: 10.1097/00007890-200004270-00027. PubMed PMID: 10836382.

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Ke B, Ritter T, Kato H, Zhai Y, Li J, Lehmann M, Busuttil RW, Volk HD, Kupiec-Weglinski JW. Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients. J Immunol. 2000 Jun 1;164(11):5739-45. doi: 10.4049/jimmunol.164.11.5739. PubMed PMID: 10820251.

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Hammer MH, Zhai Y, Katori M, Ritter T, Volk HD, Coito AJ, Kupiec-Weglinski JW. Homing of in vitro-generated donor antigen-reactive CD4+ T lymphocytes to renal allografts is alpha 4 beta 1 but not alpha L beta 2 integrin dependent. J Immunol. 2001 Jan 1;166(1):596-601. doi: 10.4049/jimmunol.166.1.596. PubMed PMID: 11123342.

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Zhai Y, Li J, Hammer M, Busuttil RW, Volk HD, Kupiec-Weglinski JW. Evidence of T cell clonality in the infectious tolerance pathway: implications toward identification of regulatory T cells. Transplantation. 2001 Jun 27;71(12):1701-8. doi: 10.1097/00007890-200106270-00001. PubMed PMID: 11455246.

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Zhai Y, Shen XD, Lehmann M, Busuttil R, Volk HD, Kupiec-Weglinski JW. T cell subsets and in vitro immune regulation in "infectious" transplantation tolerance. J Immunol. 2001 Nov 1;167(9):4814-20. doi: 10.4049/jimmunol.167.9.4814. PubMed PMID: 11673484.

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Hancock WW, Gao W, Shemmeri N, Shen XD, Gao F, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Immunopathogenesis of accelerated allograft rejection in sensitized recipients: humoral and nonhumoral mechanisms. Transplantation. 2002 May 15;73(9):1392-7. doi: 10.1097/00007890-200205150-00006. PubMed PMID: 12023615.

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Zhai Y, Shen XD, Gao F, Coito AJ, Wasowska BA, Salama A, Schmitt I, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation. J Immunol. 2002 Aug 1;169(3):1270-6. doi: 10.4049/jimmunol.169.3.1270. PubMed PMID: 12133948.

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Shen XD, Ke B, Zhai Y, Amersi F, Gao F, Anselmo DM, Busuttil RW, Kupiec-Weglinski JW. CD154-CD40 T-cell costimulation pathway is required in the mechanism of hepatic ischemia/reperfusion injury, and its blockade facilitates and depends on heme oxygenase-1 mediated cytoprotection. Transplantation. 2002 Aug 15;74(3):315-9. doi: 10.1097/00007890-200208150-00005. PubMed PMID: 12177608.

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Ke B, Shen XD, Zhai Y, Gao F, Busuttil RW, Volk HD, Kupiec-Weglinski JW. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum Gene Ther. 2002 Oct 10;13(15):1845-57. doi: 10.1089/104303402760372945. PubMed PMID: 12396617.

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Zhai Y, Meng L, Gao F, Busuttil RW, Kupiec-Weglinski JW. Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients. J Immunol. 2002 Oct 15;169(8):4667-73. doi: 10.4049/jimmunol.169.8.4667. PubMed PMID: 12370407.

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Shen XD, Ke B, Zhai Y, Gao F, Anselmo D, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Hepatology. 2003 Feb;37(2):296-303. doi: 10.1053/jhep.2003.50066. PubMed PMID: 12540779.

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Zhai Y, Kupiec-Weglinski JW. T-cell receptor beta-chain usage in directly activated alloreactive CD4+ T cells: unrestricted Vbeta gene usage with CDR3 size limitations. Transplantation. 2003 Feb 27;75(4):514-21. doi: 10.1097/01.TP.0000046939.45400.43. PubMed PMID: 12605120.

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Zhai Y, Meng L, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. J Immunol. 2003 Mar 15;170(6):3024-8. doi: 10.4049/jimmunol.170.6.3024. PubMed PMID: 12626556.

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Zhai Y, Kupiec-Weglinski JW. Regulatory T cells in kidney transplant recipients: active players but to what extent?. J Am Soc Nephrol. 2003 Jun;14(6):1706-8. doi: 10.1097/01.asn.0000072060.14828.4f. Review. PubMed PMID: 12761274.

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Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis AJ, Kupiec-Weglinski JW. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003 Aug 1;171(3):1572-80. doi: 10.4049/jimmunol.171.3.1572. PubMed PMID: 12874251.

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Tsuchihashi S, Zhai Y, Fondevila C, Busuttil RW, Kupiec-Weglinski JW. HO-1 upregulation suppresses type 1 IFN pathway in hepatic ischemia/reperfusion injury. Transplant Proc. 2005 May;37(4):1677-8. doi: 10.1016/j.transproceed.2005.03.080. PubMed PMID: 15919427.

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Shen XD, Ke B, Zhai Y, Gao F, Busuttil RW, Cheng G, Kupiec-Weglinski JW. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant. 2005 Aug;5(8):1793-800. doi: 10.1111/j.1600-6143.2005.00932.x. PubMed PMID: 15996225.

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Shen XD, Gao F, Ke B, Zhai Y, Lassman CR, Tsuchihashi S, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation. Liver Transpl. 2005 Oct;11(10):1273-81. doi: 10.1002/lt.20489. PubMed PMID: 16184555.

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Zhai Y, Shen XD, Hancock WW, Gao F, Qiao B, Lassman C, Belperio JA, Strieter RM, Busuttil RW, Kupiec-Weglinski JW. CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury. J Immunol. 2006 May 15;176(10):6313-22. doi: 10.4049/jimmunol.176.10.6313. PubMed PMID: 16670343.

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Zhai Y, Meng L, Gao F, Wang Y, Busuttil RW, Kupiec-Weglinski JW. CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent. J Immunol. 2006 May 15;176(10):5988-94. doi: 10.4049/jimmunol.176.10.5988. PubMed PMID: 16670307.

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Tsuchihashi S, Kaldas F, Chida N, Sudo Y, Tamura K, Zhai Y, Qiao B, Busuttil RW, Kupiec-Weglinski JW. FK330, a novel inducible nitric oxide synthase inhibitor, prevents ischemia and reperfusion injury in rat liver transplantation. Am J Transplant. 2006 Sep;6(9):2013-22. doi: 10.1111/j.1600-6143.2006.01435.x. Epub 2006 Jun 22. PubMed PMID: 16796718.

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Tsuchihashi S, Livhits M, Zhai Y, Busuttil RW, Araujo JA, Kupiec-Weglinski JW. Basal rather than induced heme oxygenase-1 levels are crucial in the antioxidant cytoprotection. J Immunol. 2006 Oct 1;177(7):4749-57. doi: 10.4049/jimmunol.177.7.4749. PubMed PMID: 16982915.

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Tsuchihashi S, Zhai Y, Bo Q, Busuttil RW, Kupiec-Weglinski JW. Heme oxygenase-1 mediated cytoprotection against liver ischemia and reperfusion injury: inhibition of type-1 interferon signaling. Transplantation. 2007 Jun 27;83(12):1628-34. doi: 10.1097/01.tp.0000266917.39958.47. PubMed PMID: 17589347.

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Shen XD, Ke B, Zhai Y, Tsuchihashi SI, Gao F, Duarte S, Coito A, Busuttil RW, Allison AC, Kupiec-Weglinski JW. Diannexin, a novel annexin V homodimer, protects rat liver transplants against cold ischemia-reperfusion injury. Am J Transplant. 2007 Nov;7(11):2463-71. doi: 10.1111/j.1600-6143.2007.01967.x. Epub 2007 Sep 14. PubMed PMID: 17868064.

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Zhai Y, Wang Y, Wu Z, Kupiec-Weglinski JW. Defective alloreactive CD8 T cell function and memory response in allograft recipients in the absence of CD4 help. J Immunol. 2007 Oct 1;179(7):4529-34. doi: 10.4049/jimmunol.179.7.4529. PubMed PMID: 17878349.

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Shen XD, Ke B, Zhai Y, Gao F, Tsuchihashi S, Lassman CR, Busuttil RW, Kupiec-Weglinski JW. Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl. 2007 Oct;13(10):1435-43. doi: 10.1002/lt.21251. PubMed PMID: 17902130.

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Zhai Y, Shen XD, Gao F, Zhao A, Freitas MC, Lassman C, Luster AD, Busuttil RW, Kupiec-Weglinski JW. CXCL10 regulates liver innate immune response against ischemia and reperfusion injury. Hepatology. 2008 Jan;47(1):207-14. doi: 10.1002/hep.21986. PubMed PMID: 18041715; NIHMSID:NIHMS439087.

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Zhai Y, Qiao B, Shen XD, Gao F, Busuttil RW, Cheng G, Platt JL, Volk HD, Kupiec-Weglinski JW. Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation. 2008 Apr 15;85(7):1016-22. doi: 10.1097/TP.0b013e3181684248. PubMed PMID: 18408583; NIHMSID:NIHMS439085.

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Meng L, Wu Z, Wang Y, Lassman C, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients. Transplantation. 2008 May 15;85(9):1332-8. doi: 10.1097/TP.0b013e31816c4f2b. PubMed PMID: 18475192.

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Wu Z, Wang Y, Gao F, Shen X, Zhai Y, Kupiec-Weglinski JW. Critical role of CD4 help in CD154 blockade-resistant memory CD8 T cell activation and allograft rejection in sensitized recipients. J Immunol. 2008 Jul 15;181(2):1096-102. doi: 10.4049/jimmunol.181.2.1096. PubMed PMID: 18606661; PubMed Central PMCID: PMC2975478.

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Fondevila C, Shen XD, Tsuchihashi S, Uchida Y, Freitas MC, Ke B, Busuttil RW, Kupiec-Weglinski JW. The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury. Liver Transpl. 2008 Aug;14(8):1133-41. doi: 10.1002/lt.21496. PubMed PMID: 18668646; PubMed Central PMCID: PMC2975482.

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Farmer DG, Kaldas F, Anselmo D, Katori M, Shen XD, Lassman C, Kaldas M, Clozel M, Busuttil RW, Kupiec-Weglinski J. Tezosentan, a novel endothelin receptor antagonist, markedly reduces rat hepatic ischemia and reperfusion injury in three different models. Liver Transpl. 2008 Dec;14(12):1737-44. doi: 10.1002/lt.21621. PubMed PMID: 19025917; PubMed Central PMCID: PMC2975480.

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Watson MJ, Ke B, Shen XD, Gao F, Busuttil RW, Kupiec-Weglinski JW, Farmer DG. Intestinal ischemia/reperfusion injury triggers activation of innate toll-like receptor 4 and adaptive chemokine programs. Transplant Proc. 2008 Dec;40(10):3339-41. doi: 10.1016/j.transproceed.2008.07.144. PubMed PMID: 19100385; PubMed Central PMCID: PMC2975481.

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Uchida Y, Freitas MC, Zhao D, Busuttil RW, Kupiec-Weglinski JW. The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion. Liver Transpl. 2009 Aug;15(8):939-47. doi: 10.1002/lt.21770. PubMed PMID: 19642132; PubMed Central PMCID: PMC2752954.

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Ke B, Shen XD, Gao F, Ji H, Qiao B, Zhai Y, Farmer DG, Busuttil RW, Kupiec-Weglinski JW. Adoptive transfer of ex vivo HO-1 modified bone marrow-derived macrophages prevents liver ischemia and reperfusion injury. Mol Ther. 2010 May;18(5):1019-25. doi: 10.1038/mt.2009.285. Epub 2009 Dec 22. PubMed PMID: 20029397; PubMed Central PMCID: PMC2890105.

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Yamaura K, Boenisch O, Watanabe T, Ueno T, Vanguri V, Yang J, Tanaka K, Guleria I, Borst J, Zhai Y, Kupiec-Weglinski JW, Najafian N. Differential requirement of CD27 costimulatory signaling for naïve versus alloantigen-primed effector/memory CD8+ T cells. Am J Transplant. 2010 May;10(5):1210-20. doi: 10.1111/j.1600-6143.2010.03089.x. Epub 2010 Mar 26. PubMed PMID: 20353477; PubMed Central PMCID: PMC2889922.

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Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse. Hepatology. 2010 Apr;51(4):1363-72. doi: 10.1002/hep.23442. PubMed PMID: 20091883; PubMed Central PMCID: PMC3066468.

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Freitas MC, Uchida Y, Zhao D, Ke B, Busuttil RW, Kupiec-Weglinski JW. Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion. Liver Transpl. 2010 May;16(5):600-10. doi: 10.1002/lt.22036. PubMed PMID: 20440769; PubMed Central PMCID: PMC3001321.

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Uchida Y, Freitas MC, Zhao D, Busuttil RW, Kupiec-Weglinski JW. The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Transplantation. 2010 May 15;89(9):1050-6. doi: 10.1097/TP.0b013e3181d45a98. PubMed PMID: 20160675; PubMed Central PMCID: PMC3627371.

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Uchida Y, Ke B, Freitas MC, Yagita H, Akiba H, Busuttil RW, Najafian N, Kupiec-Weglinski JW. T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner. Gastroenterology. 2010 Dec;139(6):2195-206. doi: 10.1053/j.gastro.2010.07.003. Epub 2010 Jul 13. PubMed PMID: 20637206; PubMed Central PMCID: PMC2970711.

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Ji H, Shen X, Gao F, Ke B, Freitas MC, Uchida Y, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury. Hepatology. 2010 Oct;52(4):1380-9. doi: 10.1002/hep.23843. PubMed PMID: 20815020; PubMed Central PMCID: PMC2947605.

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Shen XD, Ke B, Uchida Y, Ji H, Gao F, Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Native macrophages genetically modified to express heme oxygenase 1 protect rat liver transplants from ischemia/reperfusion injury. Liver Transpl. 2011 Feb;17(2):201-10. doi: 10.1002/lt.22214. PubMed PMID: 21280193; PubMed Central PMCID: PMC3058297.

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Farmer DG, Ke B, Shen XD, Kaldas FM, Gao F, Watson MJ, Busuttil RW, Kupiec-Weglinski JW. Interleukin-13 protects mouse intestine from ischemia and reperfusion injury through regulation of innate and adaptive immunity. Transplantation. 2011 Apr 15;91(7):737-43. doi: 10.1097/TP.0b013e31820c861a. PubMed PMID: 21311412; PubMed Central PMCID: PMC3954827.

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Ji H, Shen XD, Gao F, Busuttil RW, Zhai Y, Kupiec-Weglinski JW. Alloreactive CD8 T-cell primed/memory responses and accelerated graft rejection in B-cell-deficient sensitized mice. Transplantation. 2011 May 27;91(10):1075-81. doi: 10.1097/TP.0b013e31821578da. PubMed PMID: 21427633; PubMed Central PMCID: PMC3593653.

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Zhai Y, Busuttil RW, Kupiec-Weglinski JW. Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation. Am J Transplant. 2011 Aug;11(8):1563-9. doi: 10.1111/j.1600-6143.2011.03579.x. Epub 2011 Jun 10. Review. PubMed PMID: 21668640; PubMed Central PMCID: PMC3658307.

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Ke B, Shen XD, Ji H, Kamo N, Gao F, Freitas MC, Busuttil RW, Kupiec-Weglinski JW. HO-1-STAT3 axis in mouse liver ischemia/reperfusion injury: regulation of TLR4 innate responses through PI3K/PTEN signaling. J Hepatol. 2012 Feb;56(2):359-66. doi: 10.1016/j.jhep.2011.05.023. Epub 2011 Jul 12. PubMed PMID: 21756853; PubMed Central PMCID: PMC3444295.