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Lazard D, Barak Y, Lancet D. Bovine olfactory cilia preparation: thiol-modulated odorant-sensitive adenylyl cyclase. Biochim Biophys Acta. 1989 Sep 4;1013(1):68-72. doi: 10.1016/0167-4889(89)90129-8. PubMed PMID: 2675979.
Barak Y, Oren M. Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J. 1992 Jun;11(6):2115-21. doi: 10.1002/j.1460-2075.1992.tb05270.x. PubMed PMID: 1600943; PubMed Central PMCID: PMC556678.
Barak Y, Juven T, Haffner R, Oren M. mdm2 expression is induced by wild type p53 activity. EMBO J. 1993 Feb;12(2):461-8. doi: 10.1002/j.1460-2075.1993.tb05678.x. PubMed PMID: 8440237; PubMed Central PMCID: PMC413229.
Zauberman A, Barak Y, Ragimov N, Levy N, Oren M. Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes. EMBO J. 1993 Jul;12(7):2799-808. doi: 10.1002/j.1460-2075.1993.tb05941.x. PubMed PMID: 8334996; PubMed Central PMCID: PMC413530.
Juven T, Barak Y, Zauberman A, George DL, Oren M. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene. 1993 Dec;8(12):3411-6. PubMed PMID: 8247544.
Barak Y, Lupo A, Zauberman A, Juven T, Aloni-Grinstein R, Gottlieb E, Rotter V, Oren M. Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. Cold Spring Harb Symp Quant Biol. 1994;59:225-35. doi: 10.1101/sqb.1994.059.01.027. PubMed PMID: 7587074.
Barak Y, Gottlieb E, Juven-Gershon T, Oren M. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev. 1994 Aug 1;8(15):1739-49. doi: 10.1101/gad.8.15.1739. PubMed PMID: 7958853.
Corvi R, Savelyeva L, Breit S, Wenzel A, Handgretinger R, Barak J, Oren M, Amler L, Schwab M. Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma. Oncogene. 1995 Mar 16;10(6):1081-6. PubMed PMID: 7700632.
Zauberman A, Flusberg D, Haupt Y, Barak Y, Oren M. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res. 1995 Jul 25;23(14):2584-92. doi: 10.1093/nar/23.14.2584. PubMed PMID: 7651818; PubMed Central PMCID: PMC307078.
Haupt Y, Barak Y, Oren M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J. 1996 Apr 1;15(7):1596-606. PubMed PMID: 8612583; PubMed Central PMCID: PMC450069.
Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, Koder A, Evans RM. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell. 1999 Oct;4(4):585-95. doi: 10.1016/s1097-2765(00)80209-9. PubMed PMID: 10549290.
Miles PD, Barak Y, He W, Evans RM, Olefsky JM. Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J Clin Invest. 2000 Feb;105(3):287-92. doi: 10.1172/JCI8538. PubMed PMID: 10675354; PubMed Central PMCID: PMC377448.
Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med. 2001 Jan;7(1):48-52. doi: 10.1038/83336. PubMed PMID: 11135615.
Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell. 2001 Jan;7(1):161-71. doi: 10.1016/s1097-2765(01)00164-2. PubMed PMID: 11172721.
Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM, Boland R, Evans RM. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):303-8. doi: 10.1073/pnas.012610299. Epub 2001 Dec 26. PubMed PMID: 11756685; PubMed Central PMCID: PMC117556.
Chawla A, Lee CH, Barak Y, He W, Rosenfeld J, Liao D, Han J, Kang H, Evans RM. PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1268-73. doi: 10.1073/pnas.0337331100. Epub 2003 Jan 22. PubMed PMID: 12540828; PubMed Central PMCID: PMC298762.
Miles PD, Barak Y, Evans RM, Olefsky JM. Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E618-26. doi: 10.1152/ajpendo.00312.2002. PubMed PMID: 12556354.
Natarajan C, Muthian G, Barak Y, Evans RM, Bright JJ. Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis. J Immunol. 2003 Dec 1;171(11):5743-50. doi: 10.4049/jimmunol.171.11.5743. PubMed PMID: 14634082.
Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. Muscle-specific Pparg deletion causes insulin resistance. Nat Med. 2003 Dec;9(12):1491-7. doi: 10.1038/nm956. Epub 2003 Nov 16. PubMed PMID: 14625542.
He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15712-7. doi: 10.1073/pnas.2536828100. Epub 2003 Dec 5. PubMed PMID: 14660788; PubMed Central PMCID: PMC307633.
Shalom-Barak T, Nicholas JM, Wang Y, Zhang X, Ong ES, Young TH, Gendler SJ, Evans RM, Barak Y. Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts. Mol Cell Biol. 2004 Dec;24(24):10661-9. doi: 10.1128/MCB.24.24.10661-10669.2004. PubMed PMID: 15572671; PubMed Central PMCID: PMC533980.
Schaiff WT, Barak Y, Sadovsky Y. The pleiotropic function of PPAR gamma in the placenta. Mol Cell Endocrinol. 2006 Apr 25;249(1-2):10-5. doi: 10.1016/j.mce.2006.02.009. Epub 2006 Mar 29. Review. PubMed PMID: 16574314.
McAlpine CA, Barak Y, Matise I, Cormier RT. Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice. Int J Cancer. 2006 Nov 15;119(10):2339-46. doi: 10.1002/ijc.22115. PubMed PMID: 16858678.
Barak Y, Kim S. Genetic manipulations of PPARs: effects on obesity and metabolic disease. PPAR Res. 2007;2007:12781. doi: 10.1155/2007/12781. PubMed PMID: 17389768; PubMed Central PMCID: PMC1791068.
Schaiff WT, Knapp FF Jr, Barak Y, Biron-Shental T, Nelson DM, Sadovsky Y. Ligand-activated peroxisome proliferator activated receptor gamma alters placental morphology and placental fatty acid uptake in mice. Endocrinology. 2007 Aug;148(8):3625-34. doi: 10.1210/en.2007-0211. Epub 2007 Apr 26. PubMed PMID: 17463056.
Kim S, Huang LW, Snow KJ, Ablamunits V, Hasham MG, Young TH, Paulk AC, Richardson JE, Affourtit JP, Shalom-Barak T, Bult CJ, Barak Y. A mouse model of conditional lipodystrophy. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16627-32. doi: 10.1073/pnas.0707797104. Epub 2007 Oct 5. PubMed PMID: 17921248; PubMed Central PMCID: PMC2034232.
Barak Y, Sadovsky Y, Shalom-Barak T. PPAR Signaling in Placental Development and Function. PPAR Res. 2008;2008:142082. doi: 10.1155/2008/142082. PubMed PMID: 18288278; PubMed Central PMCID: PMC2225458.
Man MQ, Barish GD, Schmuth M, Crumrine D, Barak Y, Chang S, Jiang Y, Evans RM, Elias PM, Feingold KR. Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation. J Invest Dermatol. 2008 Feb;128(2):370-7. doi: 10.1038/sj.jid.5701026. Epub 2007 Aug 23. PubMed PMID: 17713572.
Ghosh AK, Bhattacharyya S, Wei J, Kim S, Barak Y, Mori Y, Varga J. Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator. FASEB J. 2009 Sep;23(9):2968-77. doi: 10.1096/fj.08-128736. Epub 2009 Apr 24. PubMed PMID: 19395477; PubMed Central PMCID: PMC2735362.
Szanto A, Balint BL, Nagy ZS, Barta E, Dezso B, Pap A, Szeles L, Poliska S, Oros M, Evans RM, Barak Y, Schwabe J, Nagy L. STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells. Immunity. 2010 Nov 24;33(5):699-712. doi: 10.1016/j.immuni.2010.11.009. PubMed PMID: 21093321; PubMed Central PMCID: PMC3052437.
Barak Y, Lee CH. The Molecular Basis of PPAR Function. PPAR Res. 2010;2010:510530. doi: 10.1155/2010/510530. Epub 2011 Mar 8. PubMed PMID: 21436990; PubMed Central PMCID: PMC3062958.
Majka SM, Barak Y, Klemm DJ. Concise review: adipocyte origins: weighing the possibilities. Stem Cells. 2011 Jul;29(7):1034-40. doi: 10.1002/stem.653. Review. PubMed PMID: 21544899; PubMed Central PMCID: PMC3428116.
Morán-Salvador E, López-Parra M, García-Alonso V, Titos E, Martínez-Clemente M, González-Périz A, López-Vicario C, Barak Y, Arroyo V, Clària J. Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J. 2011 Aug;25(8):2538-50. doi: 10.1096/fj.10-173716. Epub 2011 Apr 19. PubMed PMID: 21507897.
Shalom-Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy JK, Xu J, Sadovsky Y, Barak Y. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55. doi: 10.1016/j.ydbio.2012.08.021. Epub 2012 Aug 29. PubMed PMID: 22967998; PubMed Central PMCID: PMC3479343.
Morán-Salvador E, Titos E, Rius B, González-Périz A, García-Alonso V, López-Vicario C, Miquel R, Barak Y, Arroyo V, Clària J. Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells. J Hepatol. 2013 Nov;59(5):1045-53. doi: 10.1016/j.jhep.2013.06.023. Epub 2013 Jul 2. PubMed PMID: 23831119.
Larkin J, Chen B, Shi XH, Mishima T, Kokame K, Barak Y, Sadovsky Y. NDRG1 deficiency attenuates fetal growth and the intrauterine response to hypoxic injury. Endocrinology. 2014 Mar;155(3):1099-106. doi: 10.1210/en.2013-1425. Epub 2013 Jan 1. PubMed PMID: 24424031; PubMed Central PMCID: PMC3929742.
Himes KP, Young A, Koppes E, Stolz D, Barak Y, Sadovsky Y, Chaillet JR. Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism. Placenta. 2015 Apr;36(4):389-96. doi: 10.1016/j.placenta.2015.01.012. Epub 2015 Jan 29. PubMed PMID: 25662615; PubMed Central PMCID: PMC4359963.
Lee S, Pallerla SR, Kim S, Shaffer B, Simerly CR, Richard Chaillet J, Barak Y. Esrrb-Cre excises loxP-flanked alleles in early four-cell embryos. Genesis. 2016 Jan;54(1):53-61. doi: 10.1002/dvg.22912. Epub 2015 Dec 28. PubMed PMID: 26663459; PubMed Central PMCID: PMC4724263.
Shalom-Barak T, Liersemann J, Memari B, Flechner L, Devor CE, Bernardo TM, Kim S, Matsumoto N, Friedman SL, Evans RM, White JH, Barak Y. Ligand-Dependent Corepressor (LCoR) Is a Rexinoid-Inhibited Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor α Coactivator. Mol Cell Biol. 2018 May 1;38(9). doi: 10.1128/MCB.00107-17. Print 2018 May 1. PubMed PMID: 29463649; PubMed Central PMCID: PMC5902596.
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