My Bibliography

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Zhou Z, Arroum T, Luo X, Kang R, Lee YJ, Tang D, Hüttemann M, Song X. Diverse functions of cytochrome c in cell death and disease. Cell Death Differ. 2024 Apr;31(4):387-404. doi: 10.1038/s41418-024-01284-8. Epub 2024 Mar 23. Review. PubMed PMID: 38521844; PubMed Central PMCID: PMC11043370.

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Sane S, Srinivasan R, Potts RA, Eikanger M, Zagirova D, Freeling J, Reihe CA, Antony RM, Gupta BK, Lynch D, Bleeker J, Turaihi H, Pillatzki A, Zhou W, Luo X, Linnebacher M, Agany D, Zohim EG, Humphrey LE, Black AR, Rezvani K. UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer. Oncogene. 2023 May;42(21):1763-1776. doi: 10.1038/s41388-023-02686-7. Epub 2023 Apr 10. PubMed PMID: 37037900; PubMed Central PMCID: PMC10287065.

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Li J, Chen CH, O'Neill KL, Fousek-Schuller VJ, Black AR, Black JD, Zhang J, Luo X. Combined inhibition of aurora kinases and Bcl-xL induces apoptosis through select BH3-only proteins. J Biol Chem. 2023 Feb;299(2):102875. doi: 10.1016/j.jbc.2023.102875. Epub 2023 Jan 6. PubMed PMID: 36621626; PubMed Central PMCID: PMC9922828.

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Kim JH, Najy AJ, Li J, Luo X, Kim HC, Choudry MHA, Lee YJ. Involvement of Bid in the crosstalk between ferroptotic agent-induced ER stress and TRAIL-induced apoptosis. J Cell Physiol. 2022 Nov;237(11):4180-4196. doi: 10.1002/jcp.30863. Epub 2022 Aug 22. PubMed PMID: 35994698; PubMed Central PMCID: PMC9691566.

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Flores-Romero H, Hohorst L, John M, Albert MC, King LE, Beckmann L, Szabo T, Hertlein V, Luo X, Villunger A, Frenzel LP, Kashkar H, Garcia-Saez AJ. BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. EMBO J. 2022 Dec 17;41(2):e108690. doi: 10.15252/embj.2021108690. Epub 2021 Dec 21. PubMed PMID: 34931711; PubMed Central PMCID: PMC8762556.

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Lauterwasser J, Fimm-Todt F, Oelgeklaus A, Schreiner A, Funk K, Falquez-Medina H, Klesse R, Jahreis G, Zerbes RM, O'Neill K, van der Laan M, Luo X, Edlich F. Hexokinases inhibit death receptor-dependent apoptosis on the mitochondria. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33). doi: 10.1073/pnas.2021175118. PubMed PMID: 34385311; PubMed Central PMCID: PMC8379972.

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Kalimuthu K, Kim JH, Park YS, Luo X, Zhang L, Ku JL, Choudry MHA, Lee YJ. Glucose deprivation-induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity. J Cell Physiol. 2021 Sep;236(9):6666-6677. doi: 10.1002/jcp.30329. Epub 2021 Feb 15. PubMed PMID: 33586156; PubMed Central PMCID: PMC11572546.

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Lee YS, Kalimuthu K, Park YS, Luo X, Choudry MHA, Bartlett DL, Lee YJ. BAX-dependent mitochondrial pathway mediates the crosstalk between ferroptosis and apoptosis. Apoptosis. 2020 Oct;25(9-10):625-631. doi: 10.1007/s10495-020-01627-z. PubMed PMID: 32737652; PubMed Central PMCID: PMC7529973.

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Roca-Portoles A, Rodriguez-Blanco G, Sumpton D, Cloix C, Mullin M, Mackay GM, O'Neill K, Lemgruber L, Luo X, Tait SWG. Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition. Cell Death Dis. 2020 Aug 13;11(8):616. doi: 10.1038/s41419-020-02867-2. PubMed PMID: 32792521; PubMed Central PMCID: PMC7426836.

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Luo X, O'Neill KL, Huang K. The third model of Bax/Bak activation: a Bcl-2 family feud finally resolved?. F1000Res. 2020;9. doi: 10.12688/f1000research.25607.1. eCollection 2020. Review. PubMed PMID: 32802314; PubMed Central PMCID: PMC7411521.

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Haschka MD, Karbon G, Soratroi C, O'Neill KL, Luo X, Villunger A. MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment. Cell Death Differ. 2020 Aug;27(8):2297-2312. doi: 10.1038/s41418-020-0503-6. Epub 2020 Feb 3. PubMed PMID: 32015503; PubMed Central PMCID: PMC7370223.

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Kour S, Rana S, Contreras JI, King HM, Robb CM, Sonawane YA, Bendjennat M, Crawford AJ, Barger CJ, Kizhake S, Luo X, Hollingsworth MA, Natarajan A. CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax. Mol Pharmacol. 2019 Oct;96(4):419-429. doi: 10.1124/mol.119.116855. PubMed PMID: 31467029; PubMed Central PMCID: PMC6726458.

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Huang K, O'Neill KL, Li J, Zhou W, Han N, Pang X, Wu W, Struble L, Borgstahl G, Liu Z, Zhang L, Luo X. BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis. Cell Res. 2019 Nov;29(11):942-952. doi: 10.1038/s41422-019-0231-y. Epub 2019 Sep 24. PubMed PMID: 31551537; PubMed Central PMCID: PMC6888900.

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Milani M, Beckett AJ, Al-Zebeeby A, Luo X, Prior IA, Cohen GM, Varadarajan S. DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis. Cell Death Discov. 2019;5:117. doi: 10.1038/s41420-019-0199-x. eCollection 2019. PubMed PMID: 31341643; PubMed Central PMCID: PMC6637195.

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Farmer T, O'Neill KL, Naslavsky N, Luo X, Caplan S. Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane. Mol Biol Cell. 2019 May 1;30(10):1138-1146. doi: 10.1091/mbc.E19-01-0044. Epub 2019 Mar 6. PubMed PMID: 30840537; PubMed Central PMCID: PMC6724524.

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Wu W, He K, Guo Q, Chen J, Zhang M, Huang K, Yang D, Wu L, Deng Y, Luo X, Yu H, Ding Q, Xiang G. SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p. J Cell Mol Med. 2019 May;23(5):3118-3129. doi: 10.1111/jcmm.14134. Epub 2019 Feb 14. PubMed PMID: 30762286; PubMed Central PMCID: PMC6484412.

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Greaves G, Milani M, Butterworth M, Carter RJ, Byrne DP, Eyers PA, Luo X, Cohen GM, Varadarajan S. BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X(L). Cell Death Differ. 2019 Jun;26(6):1037-1047. doi: 10.1038/s41418-018-0183-7. Epub 2018 Sep 5. PubMed PMID: 30185825; PubMed Central PMCID: PMC6748112.

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Contreras JI, Robb CM, King HM, Baxter J, Crawford AJ, Kour S, Kizhake S, Sonawane YA, Rana S, Hollingsworth MA, Luo X, Natarajan A. Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy. ACS Chem Biol. 2018 May 18;13(5):1148-1152. doi: 10.1021/acschembio.8b00077. Epub 2018 Apr 5. PubMed PMID: 29608269; PubMed Central PMCID: PMC6119178.

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Zhang J, Huang K, O'Neill KL, Pang X, Luo X. Bax/Bak activation in the absence of Bid, Bim, Puma, and p53. Cell Death Dis. 2016 Jun 16;7(6):e2266. doi: 10.1038/cddis.2016.167. PubMed PMID: 27310874; PubMed Central PMCID: PMC5143395.

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O'Neill KL, Huang K, Zhang J, Chen Y, Luo X. Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane. Genes Dev. 2016 Apr 15;30(8):973-88. doi: 10.1101/gad.276725.115. Epub 2016 Apr 7. PubMed PMID: 27056669; PubMed Central PMCID: PMC4840302.

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Huang K, Zhang J, O'Neill KL, Gurumurthy CB, Quadros RM, Tu Y, Luo X. Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis. J Biol Chem. 2016 May 27;291(22):11843-51. doi: 10.1074/jbc.M115.711051. Epub 2016 Apr 6. PubMed PMID: 27053107; PubMed Central PMCID: PMC4882451.

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Pang X, Zhang J, Lopez H, Wang Y, Li W, O'Neill KL, Evans JJ, George NM, Long J, Chen Y, Luo X. The carboxyl-terminal tail of Noxa protein regulates the stability of Noxa and Mcl-1. J Biol Chem. 2014 Jun 20;289(25):17802-11. doi: 10.1074/jbc.M114.548172. Epub 2014 May 8. PubMed PMID: 24811167; PubMed Central PMCID: PMC4067213.

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Menezes MR, Waisertreiger IS, Lopez-Bertoni H, Luo X, Pavlov YI. Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells. PLoS One. 2012;7(2):e32313. doi: 10.1371/journal.pone.0032313. Epub 2012 Feb 27. PubMed PMID: 22384212; PubMed Central PMCID: PMC3288088.

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Rajule R, Bryant VC, Lopez H, Luo X, Natarajan A. Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study. Bioorg Med Chem. 2012 Apr 1;20(7):2227-34. doi: 10.1016/j.bmc.2012.02.022. Epub 2012 Feb 16. PubMed PMID: 22386982; PubMed Central PMCID: PMC3303926.

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Pang X, Moussa SH, Targy NM, Bose JL, George NM, Gries C, Lopez H, Zhang L, Bayles KW, Young R, Luo X. Active Bax and Bak are functional holins. Genes Dev. 2011 Nov 1;25(21):2278-90. doi: 10.1101/gad.171645.111. Epub 2011 Oct 17. PubMed PMID: 22006182; PubMed Central PMCID: PMC3219232.

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Chen Q, Bryant VC, Lopez H, Kelly DL, Luo X, Natarajan A. 2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1929-32. doi: 10.1016/j.bmcl.2011.02.055. Epub 2011 Feb 17. PubMed PMID: 21376584; PubMed Central PMCID: PMC3063321.

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Zhang L, Lopez H, George NM, Liu X, Pang X, Luo X. Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways. Cell Death Differ. 2011 May;18(5):864-73. doi: 10.1038/cdd.2010.152. Epub 2010 Nov 26. PubMed PMID: 21113147; PubMed Central PMCID: PMC3074052.

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Cox JL, Mallanna SK, Luo X, Rizzino A. Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes. PLoS One. 2010 Nov 12;5(11):e15486. doi: 10.1371/journal.pone.0015486. PubMed PMID: 21103394; PubMed Central PMCID: PMC2980493.

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Cleland MM, Norris KL, Karbowski M, Wang C, Suen DF, Jiao S, George NM, Luo X, Li Z, Youle RJ. Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ. 2011 Feb;18(2):235-47. doi: 10.1038/cdd.2010.89. Epub 2010 Jul 30. PubMed PMID: 20671748; PubMed Central PMCID: PMC2970747.

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Lopez H, Zhang L, George NM, Liu X, Pang X, Evans JJD, Targy NM, Luo X. Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage. J Biol Chem. 2010 May 14;285(20):15016-15026. doi: 10.1074/jbc.M109.086231. Epub 2010 Mar 11. PubMed PMID: 20223826; PubMed Central PMCID: PMC2865346.

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George NM, Targy N, Evans JJ, Zhang L, Luo X. Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process. J Biol Chem. 2010 Jan 8;285(2):1384-92. doi: 10.1074/jbc.M109.049924. Epub 2009 Oct 30. PubMed PMID: 19880508; PubMed Central PMCID: PMC2801264.

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Liu X, Luo X, Shi Y, Zhu GD, Penning T, Giranda VL, Luo Y. Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage. Cancer Biol Ther. 2008 Jun;7(6):934-41. doi: 10.4161/cbt.7.6.5933. Epub 2008 Mar 19. PubMed PMID: 18376143.

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George NM, Evans JJ, Luo X. A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax. Genes Dev. 2007 Aug 1;21(15):1937-48. doi: 10.1101/gad.1553607. PubMed PMID: 17671092; PubMed Central PMCID: PMC1935031.

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Huang Y, Erdmann N, Peng H, Herek S, Davis JS, Luo X, Ikezu T, Zheng J. TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation. J Immunol. 2006 Aug 15;177(4):2304-13. doi: 10.4049/jimmunol.177.4.2304. PubMed PMID: 16887991; PubMed Central PMCID: PMC1892167.

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Basma H, El-Refaey H, Sgagias MK, Cowan KH, Luo X, Cheng PW. BCL-2 antisense and cisplatin combination treatment of MCF-7 breast cancer cells with or without functional p53. J Biomed Sci. 2005 Dec;12(6):999-1011. doi: 10.1007/s11373-005-9025-y. Epub 2005 Oct 14. PubMed PMID: 16228292.

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Li LY, Luo X, Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature. 2001 Jul 5;412(6842):95-9. doi: 10.1038/35083620. PubMed PMID: 11452314.

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Lutter M, Fang M, Luo X, Nishijima M, Xie X, Wang X. Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat Cell Biol. 2000 Oct;2(10):754-61. doi: 10.1038/35036395. PubMed PMID: 11025668.

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Budihardjo I, Oliver H, Lutter M, Luo X, Wang X. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol. 1999;15:269-90. doi: 10.1146/annurev.cellbio.15.1.269. Review. PubMed PMID: 10611963.

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Qyang Y, Luo X, Lu T, Ismail PM, Krylov D, Vinson C, Sawadogo M. Cell-type-dependent activity of the ubiquitous transcription factor USF in cellular proliferation and transcriptional activation. Mol Cell Biol. 1999 Feb;19(2):1508-17. doi: 10.1128/MCB.19.2.1508. PubMed PMID: 9891084; PubMed Central PMCID: PMC116079.

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Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1998 Aug 21;94(4):481-90. doi: 10.1016/s0092-8674(00)81589-5. PubMed PMID: 9727491.

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Liu X, Li P, Widlak P, Zou H, Luo X, Garrard WT, Wang X. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8461-6. doi: 10.1073/pnas.95.15.8461. PubMed PMID: 9671700; PubMed Central PMCID: PMC21098.

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Luo X, Sawadogo M. Functional domains of the transcription factor USF2: atypical nuclear localization signals and context-dependent transcriptional activation domains. Mol Cell Biol. 1996 Apr;16(4):1367-75. doi: 10.1128/MCB.16.4.1367. PubMed PMID: 8657110; PubMed Central PMCID: PMC231121.

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Luo X, Sawadogo M. Antiproliferative properties of the USF family of helix-loop-helix transcription factors. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1308-13. doi: 10.1073/pnas.93.3.1308. PubMed PMID: 8577760; PubMed Central PMCID: PMC40076.

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Meier JL, Luo X, Sawadogo M, Straus SE. The cellular transcription factor USF cooperates with varicella-zoster virus immediate-early protein 62 to symmetrically activate a bidirectional viral promoter. Mol Cell Biol. 1994 Oct;14(10):6896-906. doi: 10.1128/mcb.14.10.6896-6906.1994. PubMed PMID: 7935407; PubMed Central PMCID: PMC359220.

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Lin Q, Luo X, Sawadogo M. Archaic structure of the gene encoding transcription factor USF. J Biol Chem. 1994 Sep 30;269(39):23894-903. PubMed PMID: 7523363.