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Yuan S, Liu Y, Peng H, Tang C, Hennig GW, Wang Z, Wang L, Yu T, Klukovich R, Zhang Y, Zheng H, Xu C, Wu J, Hess RA, Yan W. Motile cilia of the male reproductive system require miR-34/miR-449 for development and function to generate luminal turbulence. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3584-3593. doi: 10.1073/pnas.1817018116. Epub 2019 Jan 18. PubMed PMID: 30659149; PubMed Central PMCID: PMC6397547.
Klukovich R, Nilsson E, Sadler-Riggleman I, Beck D, Xie Y, Yan W, Skinner MK. Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease. Sci Rep. 2019 Feb 18;9(1):2209. doi: 10.1038/s41598-019-38741-1. PubMed PMID: 30778168; PubMed Central PMCID: PMC6379561.
Nilsson E, Klukovich R, Sadler-Riggleman I, Beck D, Xie Y, Yan W, Skinner MK. Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufiency. Epigenetics. 2018;13(8):875-895. doi: 10.1080/15592294.2018.1521223. Epub 2018 Oct 2. PubMed PMID: 30207508; PubMed Central PMCID: PMC6224216.
Wang Z, Lee S, Oliver D, Yuan S, Tang C, Wang Y, Zheng H, Yan W. Prps1l1, a testis-specific gene, is dispensable for mouse spermatogenesis. Mol Reprod Dev. 2018 Oct;85(10):802-804. doi: 10.1002/mrd.23053. Epub 2018 Sep 7. PubMed PMID: 30113107; PubMed Central PMCID: PMC6202250.
Grozdanov PN, Li J, Yu P, Yan W, MacDonald CC. Cstf2t Regulates expression of histones and histone-like proteins in male germ cells. Andrology. 2018 Jul;6(4):605-615. doi: 10.1111/andr.12488. Epub 2018 Apr 19. PubMed PMID: 29673127; PubMed Central PMCID: PMC6105451.
Chuang TD, Xie Y, Yan W, Khorram O. Next-generation sequencing reveals differentially expressed small noncoding RNAs in uterine leiomyoma. Fertil Steril. 2018 May;109(5):919-929. doi: 10.1016/j.fertnstert.2018.01.034. PubMed PMID: 29778390; PubMed Central PMCID: PMC6445395.
Barouki R, Melén E, Herceg Z, Beckers J, Chen J, Karagas M, Puga A, Xia Y, Chadwick L, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K. Epigenetics as a mechanism linking developmental exposures to long-term toxicity. Environ Int. 2018 May;114:77-86. doi: 10.1016/j.envint.2018.02.014. Epub 2018 Feb 27. Review. PubMed PMID: 29499450; PubMed Central PMCID: PMC5899930.
Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nat Cell Biol. 2018 May;20(5):535-540. doi: 10.1038/s41556-018-0087-2. Epub 2018 Apr 25. PubMed PMID: 29695786; PubMed Central PMCID: PMC5926820.
Ben Maamar M, Sadler-Riggleman I, Beck D, McBirney M, Nilsson E, Klukovich R, Xie Y, Tang C, Yan W, Skinner MK. Alterations in sperm DNA methylation, non-coding RNA expression, and histone retention mediate vinclozolin-induced epigenetic transgenerational inheritance of disease. Environ Epigenet. 2018 Apr;4(2):dvy010. doi: 10.1093/eep/dvy010. eCollection 2018 Apr. PubMed PMID: 29732173; PubMed Central PMCID: PMC5920293.
Skinner MK, Ben Maamar M, Sadler-Riggleman I, Beck D, Nilsson E, McBirney M, Klukovich R, Xie Y, Tang C, Yan W. Alterations in sperm DNA methylation, non-coding RNA and histone retention associate with DDT-induced epigenetic transgenerational inheritance of disease. Epigenetics Chromatin. 2018 Feb 27;11(1):8. doi: 10.1186/s13072-018-0178-0. PubMed PMID: 29482626; PubMed Central PMCID: PMC5827984.
Tang C, Klukovich R, Peng H, Wang Z, Yu T, Zhang Y, Zheng H, Klungland A, Yan W. ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E325-E333. doi: 10.1073/pnas.1717794115. Epub 2017 Dec 26. PubMed PMID: 29279410; PubMed Central PMCID: PMC5777073.
Yu T, Tang C, Zhang Y, Zhang R, Yan W. Microfluidics-based digital quantitative PCR for single-cell small RNA quantification. Biol Reprod. 2017 Sep 1;97(3):490-496. doi: 10.1093/biolre/iox102. PubMed PMID: 29024970; PubMed Central PMCID: PMC6248614.
Zhang Y, Tang C, Yu T, Zhang R, Zheng H, Yan W. MicroRNAs control mRNA fate by compartmentalization based on 3' UTR length in male germ cells. Genome Biol. 2017 Jun 15;18(1):105. doi: 10.1186/s13059-017-1243-x. PubMed PMID: 28615029; PubMed Central PMCID: PMC5471846.
Yan W Editor-In-Chief Biology Of Reproduction. piRNA-independent PIWI function in spermatogenesis and male fertility. Biol Reprod. 2017 Jun 1;96(6):1121-1123. doi: 10.1093/biolre/iox055. PubMed PMID: 28595264; PubMed Central PMCID: PMC6279087.
Yanagimachi R, Harumi T, Matsubara H, Yan W, Yuan S, Hirohashi N, Iida T, Yamaha E, Arai K, Matsubara T, Andoh T, Vines C, Cherr GN. Chemical and physical guidance of fish spermatozoa into the egg through the micropyle†,‡. Biol Reprod. 2017 Apr 1;96(4):780-799. doi: 10.1093/biolre/iox015. PubMed PMID: 28371886; PubMed Central PMCID: PMC6355103.
Yan W. Mark it for destruction: a novel role of mRNA methylation in maternal-to-zygotic transition†. Biol Reprod. 2017 Apr 1;96(4):829-830. doi: 10.1093/biolre/iox016. PubMed PMID: 28371885; PubMed Central PMCID: PMC6279102.
Halim D, Wilson MP, Oliver D, Brosens E, Verheij JB, Han Y, Nanda V, Lyu Q, Doukas M, Stoop H, Brouwer RW, van IJcken WF, Slivano OJ, Burns AJ, Christie CK, de Mesy Bentley KL, Brooks AS, Tibboel D, Xu S, Jin ZG, Djuwantono T, Yan W, Alves MM, Hofstra RM, Miano JM. Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2739-E2747. doi: 10.1073/pnas.1620507114. Epub 2017 Mar 14. PubMed PMID: 28292896; PubMed Central PMCID: PMC5380076.
Yan W. An interview with Magdalena Zernicka-Goetz. Biol Reprod. 2017 Mar 1;96(3):503-504. doi: 10.1093/biolre/iox003. PubMed PMID: 28339611; PubMed Central PMCID: PMC6279055.
Yuan S, Tang C, Schuster A, Zhang Y, Zheng H, Yan W. Paternal pachytene piRNAs are not required for fertilization, embryonic development and sperm-mediated epigenetic inheritance in mice. Environ Epigenet. 2016 Dec;2(4). doi: 10.1093/eep/dvw021. Epub 2016 Dec 22. PubMed PMID: 28983410; PubMed Central PMCID: PMC5625633.
Chen Q, Yan W, Duan E. Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications. Nat Rev Genet. 2016 Dec;17(12):733-743. doi: 10.1038/nrg.2016.106. Epub 2016 Oct 3. Review. PubMed PMID: 27694809; PubMed Central PMCID: PMC5441558.
Fededa JP, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich JA, Gerlich DW. MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 2016 Nov 15;35(22):2386-2398. doi: 10.15252/embj.201694056. Epub 2016 Oct 5. PubMed PMID: 27707753; PubMed Central PMCID: PMC5109238.
Schuster A, Tang C, Xie Y, Ortogero N, Yuan S, Yan W. SpermBase: A Database for Sperm-Borne RNA Contents. Biol Reprod. 2016 Nov 1;95(5):99. doi: 10.1095/biolreprod.116.142190. Epub 2016 Sep 14. PubMed PMID: 27628216; PubMed Central PMCID: PMC5178153.
Bao J, Vitting-Seerup K, Waage J, Tang C, Ge Y, Porse BT, Yan W. UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet. 2016 May;12(5):e1005863. doi: 10.1371/journal.pgen.1005863. eCollection 2016 May. PubMed PMID: 27149259; PubMed Central PMCID: PMC4858225.
Schuster A, Skinner MK, Yan W. Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs. Environ Epigenet. 2016;2(1). doi: 10.1093/eep/dvw001. Epub 2016 Mar 9. PubMed PMID: 27390623; PubMed Central PMCID: PMC4933025.
Yuan S, Schuster A, Tang C, Yu T, Ortogero N, Bao J, Zheng H, Yan W. Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development. Development. 2016 Feb 15;143(4):635-47. doi: 10.1242/dev.131755. Epub 2015 Dec 30. PubMed PMID: 26718009; PubMed Central PMCID: PMC4760322.
Sosa E, Flores L, Yan W, McCarrey JR. Escape of X-linked miRNA genes from meiotic sex chromosome inactivation. Development. 2015 Nov 1;142(21):3791-800. doi: 10.1242/dev.127191. Epub 2015 Sep 22. PubMed PMID: 26395485; PubMed Central PMCID: PMC4647214.
Oliver D, Yuan S, McSwiggin H, Yan W. Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection. PLoS One. 2015;10(6):e0129457. doi: 10.1371/journal.pone.0129457. eCollection 2015. PubMed PMID: 26053263; PubMed Central PMCID: PMC4459985.
Yuan S, Swiggin HM, Zheng H, Yan W. A testis-specific gene, Ubqlnl, is dispensable for mouse embryonic development and spermatogenesis. Mol Reprod Dev. 2015 Jun;82(6):408-9. doi: 10.1002/mrd.22504. Epub 2015 Jun 3. PubMed PMID: 26043068; PubMed Central PMCID: PMC4481141.
Yuan S, Qin W, Riordan CR, McSwiggin H, Zheng H, Yan W. Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice. Mol Reprod Dev. 2015 Apr;82(4):266-7. doi: 10.1002/mrd.22475. Epub 2015 Mar 16. PubMed PMID: 25776854; PubMed Central PMCID: PMC4397168.
Song HW, Bettegowda A, Oliver D, Yan W, Phan MH, de Rooij DG, Corbett MA, Wilkinson MF. shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects. PLoS One. 2015;10(3):e0118549. doi: 10.1371/journal.pone.0118549. eCollection 2015. PubMed PMID: 25790000; PubMed Central PMCID: PMC4366048.
Yuan S, Oliver D, Schuster A, Zheng H, Yan W. Breeding scheme and maternal small RNAs affect the efficiency of transgenerational inheritance of a paramutation in mice. Sci Rep. 2015 Mar 18;5:9266. doi: 10.1038/srep09266. PubMed PMID: 25783852; PubMed Central PMCID: PMC4363887.
Yuan S, Stratton CJ, Bao J, Zheng H, Bhetwal BP, Yanagimachi R, Yan W. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E430-9. doi: 10.1073/pnas.1424648112. Epub 2015 Jan 20. PubMed PMID: 25605924; PubMed Central PMCID: PMC4321249.
Yuan S, Tang C, Zhang Y, Wu J, Bao J, Zheng H, Xu C, Yan W. mir-34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice. Biol Open. 2015 Jan 23;4(2):212-23. doi: 10.1242/bio.201410959. PubMed PMID: 25617420; PubMed Central PMCID: PMC4365490.
Bao J, Tang C, Yuan S, Porse BT, Yan W. UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development. 2015 Jan 15;142(2):352-62. doi: 10.1242/dev.115642. Epub 2014 Dec 11. PubMed PMID: 25503407; PubMed Central PMCID: PMC4302838.
Schuster A, Hennig GW, Ortogero N, Luong D, Yan W. In silico identification of novel endo-siRNAs. Methods Mol Biol. 2015;1218:341-51. doi: 10.1007/978-1-4939-1538-5_21. PubMed PMID: 25319662.
Ortogero N, Hennig GW, Luong D, Yan W. Computer-assisted annotation of small RNA transcriptomes. Methods Mol Biol. 2015;1218:353-64. doi: 10.1007/978-1-4939-1538-5_22. PubMed PMID: 25319663.
Bao J, Tang C, Li J, Zhang Y, Bhetwal BP, Zheng H, Yan W. RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility. PLoS Genet. 2014 Dec;10(12):e1004825. doi: 10.1371/journal.pgen.1004825. eCollection 2014 Dec. PubMed PMID: 25474150; PubMed Central PMCID: PMC4256260.
Yan W. Potential roles of noncoding RNAs in environmental epigenetic transgenerational inheritance. Mol Cell Endocrinol. 2014 Dec;398(1-2):24-30. doi: 10.1016/j.mce.2014.09.008. Epub 2014 Sep 16. Review. PubMed PMID: 25224488; PubMed Central PMCID: PMC4262681.
Ortogero N, Schuster AS, Oliver DK, Riordan CR, Hong AS, Hennig GW, Luong D, Bao J, Bhetwal BP, Ro S, McCarrey JR, Yan W. A novel class of somatic small RNAs similar to germ cell pachytene PIWI-interacting small RNAs. J Biol Chem. 2014 Nov 21;289(47):32824-34. doi: 10.1074/jbc.M114.613232. Epub 2014 Oct 15. PubMed PMID: 25320077; PubMed Central PMCID: PMC4239631.
Yuan S, Ortogero N, Wu Q, Zheng H, Yan W. Murine follicular development requires oocyte DICER, but not DROSHA. Biol Reprod. 2014 Aug;91(2):39. doi: 10.1095/biolreprod.114.119370. Epub 2014 Jul 2. PubMed PMID: 24990804; PubMed Central PMCID: PMC4435415.
Wu J, Bao J, Kim M, Yuan S, Tang C, Zheng H, Mastick GS, Xu C, Yan W. Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2851-7. doi: 10.1073/pnas.1407777111. Epub 2014 Jun 30. PubMed PMID: 24982181; PubMed Central PMCID: PMC4104921.
Bao J, Zhang Y, Schuster AS, Ortogero N, Nilsson EE, Skinner MK, Yan W. Conditional inactivation of Miwi2 reveals that MIWI2 is only essential for prospermatogonial development in mice. Cell Death Differ. 2014 May;21(5):783-96. doi: 10.1038/cdd.2014.5. Epub 2014 Jan 24. PubMed PMID: 24464225; PubMed Central PMCID: PMC3978311.
Dong WW, Huang HL, Yang W, Liu J, Yu Y, Zhou SL, Wang W, Lv XC, Li ZY, Zhang MY, Zheng ZH, Yan W. Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis. Asian J Androl. 2014 Jan-Feb;16(1):124-30. doi: 10.4103/1008-682X.122592. PubMed PMID: 24369145; PubMed Central PMCID: PMC3901870.
Bao J, Wu J, Schuster AS, Hennig GW, Yan W. Expression profiling reveals developmentally regulated lncRNA repertoire in the mouse male germline. Biol Reprod. 2013 Nov;89(5):107. doi: 10.1095/biolreprod.113.113308. Print 2013 Nov. PubMed PMID: 24048575; PubMed Central PMCID: PMC4076377.
Yuan S, Zheng H, Zheng Z, Yan W. Proteomic analyses reveal a role of cytoplasmic droplets as an energy source during epididymal sperm maturation. PLoS One. 2013;8(10):e77466. doi: 10.1371/journal.pone.0077466. eCollection 2013. PubMed PMID: 24155961; PubMed Central PMCID: PMC3796460.
Bao J, Yuan S, Maestas A, Bhetwal BP, Schuster A, Yan W. Stk31 is dispensable for embryonic development and spermatogenesis in mice. Mol Reprod Dev. 2013 Oct;80(10):786. doi: 10.1002/mrd.22225. Epub 2013 Sep 12. PubMed PMID: 23929668; PubMed Central PMCID: PMC5441557.
Bao J, Ma HY, Schuster A, Lin YM, Yan W. Incomplete cre-mediated excision leads to phenotypic differences between Stra8-iCre; Mov10l1(lox/lox) and Stra8-iCre; Mov10l1(lox/Δ) mice. Genesis. 2013 Jul;51(7):481-90. doi: 10.1002/dvg.22389. Epub 2013 Mar 30. PubMed PMID: 23554062; PubMed Central PMCID: PMC3918465.
Ro S, Ma HY, Park C, Ortogero N, Song R, Hennig GW, Zheng H, Lin YM, Moro L, Hsieh JT, Yan W. The mitochondrial genome encodes abundant small noncoding RNAs. Cell Res. 2013 Jun;23(6):759-74. doi: 10.1038/cr.2013.37. Epub 2013 Mar 12. PubMed PMID: 23478297; PubMed Central PMCID: PMC3674384.
Ortogero N, Hennig GW, Langille C, Ro S, McCarrey JR, Yan W. Computer-assisted annotation of murine Sertoli cell small RNA transcriptome. Biol Reprod. 2013 Jan;88(1):3. doi: 10.1095/biolreprod.112.102269. Print 2013 Jan. PubMed PMID: 23136297; PubMed Central PMCID: PMC4434943.
Idler RK, Hennig GW, Yan W. Bioinformatic identification of novel elements potentially involved in messenger RNA fate control during spermatogenesis. Biol Reprod. 2012 Jun;87(6):138. doi: 10.1095/biolreprod.112.102434. Print 2012 Jun. PubMed PMID: 23053435; PubMed Central PMCID: PMC4435427.
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