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Kim LJ, Freire C, Fleury Curado T, Jun JC, Polotsky VY. The Role of Animal Models in Developing Pharmacotherapy for Obstructive Sleep Apnea. J Clin Med. 2019 Nov 22;8(12). doi: 10.3390/jcm8122049. Review. PubMed PMID: 31766589; PubMed Central PMCID: PMC6947279.
Shin MK, Eraso CC, Mu YP, Gu C, Yeung BHY, Kim LJ, Liu XR, Wu ZJ, Paudel O, Pichard LE, Shirahata M, Tang WY, Sham JSK, Polotsky VY. Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body. Circ Res. 2019 Nov 8;125(11):989-1002. doi: 10.1161/CIRCRESAHA.119.315338. Epub 2019 Sep 23. PubMed PMID: 31545149; PubMed Central PMCID: PMC6842127.
Shin MK, Kim LJ, Caballero-Eraso C, Polotsky VY. Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing. J Vis Exp. 2019 Oct 25;(152). doi: 10.3791/60298. PubMed PMID: 31710041; PubMed Central PMCID: PMC6892346.
Jun JC, Polotsky VY. Obstructive sleep apnoea and susceptibility to cardiovascular disease: A blessing or curse of old age?. Respirology. 2019 Aug 14;. doi: 10.1111/resp.13679. [Epub ahead of print] PubMed PMID: 31411783.
Arias RS, Etienne B, Polotsky VY, Checkley W, Schwartz AR, Pham LV. Upright posture increases oxyhemoglobin saturation in Peruvian highlanders. Respir Physiol Neurobiol. 2019 Aug;266:138-143. doi: 10.1016/j.resp.2019.04.015. Epub 2019 May 24. PubMed PMID: 31048020; PubMed Central PMCID: PMC6753782.
Fleury Curado T, Berger S, Polotsky VY. Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner?. Am J Respir Crit Care Med. 2019 May 15;199(10):1186-1187. doi: 10.1164/rccm.201811-2135ED. PubMed PMID: 30521761; PubMed Central PMCID: PMC6519854.
Berger S, Pho H, Fleury-Curado T, Bevans-Fonti S, Younas H, Shin MK, Jun JC, Anokye-Danso F, Ahima RS, Enquist LW, Mendelowitz D, Schwartz AR, Polotsky VY. Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity. Am J Respir Crit Care Med. 2019 Mar 15;199(6):773-783. doi: 10.1164/rccm.201805-0879OC. PubMed PMID: 30309268; PubMed Central PMCID: PMC6423095.
Younas H, Vieira M, Gu C, Lee R, Shin MK, Berger S, Loube J, Nelson A, Bevans-Fonti S, Zhong Q, D'Alessio FR, McCormack MC, Hansel NN, Mitzner W, Polotsky VY. Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet. Sci Rep. 2019 Jan 22;9(1):279. doi: 10.1038/s41598-018-36651-2. PubMed PMID: 30670753; PubMed Central PMCID: PMC6342916.
Arble DM, Schwartz AR, Polotsky VY, Sandoval DA, Seeley RJ. Vertical sleeve gastrectomy improves ventilatory drive through a leptin-dependent mechanism. JCI Insight. 2019 Jan 10;4(1). doi: 10.1172/jci.insight.124469. [Epub ahead of print] PubMed PMID: 30626748; PubMed Central PMCID: PMC6485355.
Caballero-Eraso C, Shin MK, Pho H, Kim LJ, Pichard LE, Wu ZJ, Gu C, Berger S, Pham L, Yeung HB, Shirahata M, Schwartz AR, Tang WW, Sham JSK, Polotsky VY. Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response. J Physiol. 2019 Jan;597(1):151-172. doi: 10.1113/JP276900. Epub 2018 Nov 29. PubMed PMID: 30285278; PubMed Central PMCID: PMC6312428.
Fleury Curado T, Oliven A, Sennes LU, Polotsky VY, Eisele D, Schwartz AR. Neurostimulation Treatment of OSA. Chest. 2018 Dec;154(6):1435-1447. doi: 10.1016/j.chest.2018.08.1070. Epub 2018 Sep 14. Review. PubMed PMID: 30222959; PubMed Central PMCID: PMC6335261.
Nishimura Y, Arias RS, Pho H, Pham LV, Curado TF, Polotsky VY, Schwartz AR. A Novel Non-invasive Approach for Measuring Upper Airway Collapsibility in Mice. Front Neurol. 2018;9:985. doi: 10.3389/fneur.2018.00985. eCollection 2018. PubMed PMID: 30524362; PubMed Central PMCID: PMC6256100.
Fleury Curado TA, Pho H, Dergacheva O, Berger S, Lee R, Freire C, Asherov A, Sennes LU, Mendelowitz D, Schwartz AR, Polotsky VY. Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice. Front Neurol. 2018;9:962. doi: 10.3389/fneur.2018.00962. eCollection 2018. PubMed PMID: 30487776; PubMed Central PMCID: PMC6246694.
Pham LV, Schwartz AR, Polotsky VY. Integrating loop gain into the understanding of obstructive sleep apnoea mechanisms. J Physiol. 2018 Sep;596(17):3819-3820. doi: 10.1113/JP276590. Epub 2018 Jul 23. PubMed PMID: 29968907; PubMed Central PMCID: PMC6117553.
Fleury Curado T, Pho H, Berger S, Caballero-Eraso C, Shin MK, Sennes LU, Pham L, Schwartz AR, Polotsky VY. Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity. Sleep. 2018 Aug 1;41(8). doi: 10.1093/sleep/zsy089. PubMed PMID: 29767787; PubMed Central PMCID: PMC6093346.
Holingue C, Wennberg A, Berger S, Polotsky VY, Spira AP. Disturbed sleep and diabetes: A potential nexus of dementia risk. Metabolism. 2018 Jul;84:85-93. doi: 10.1016/j.metabol.2018.01.021. Epub 2018 Feb 1. Review. PubMed PMID: 29409842; PubMed Central PMCID: PMC5995651.
Drager LF, Tavoni TM, Silva VM, Santos RD, Pedrosa RP, Bortolotto LA, Vinagre CG, Polotsky VY, Lorenzi-Filho G, Maranhao RC. Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism. J Lipid Res. 2018 Jun;59(6):1027-1033. doi: 10.1194/jlr.M083436. Epub 2018 Apr 8. PubMed PMID: 29628442; PubMed Central PMCID: PMC5983397.
Fricke K, Vieira M, Younas H, Shin MK, Bevans-Fonti S, Berger S, Lee R, D'Alessio FR, Zhong Q, Nelson A, Loube J, Sanchez I, Hansel NN, Mitzner W, Polotsky VY. High fat diet induces airway hyperresponsiveness in mice. Sci Rep. 2018 Apr 23;8(1):6404. doi: 10.1038/s41598-018-24759-4. PubMed PMID: 29686414; PubMed Central PMCID: PMC5913253.
Berger S, Polotsky VY. Leptin and Leptin Resistance in the Pathogenesis of Obstructive Sleep Apnea: A Possible Link to Oxidative Stress and Cardiovascular Complications. Oxid Med Cell Longev. 2018;2018:5137947. doi: 10.1155/2018/5137947. eCollection 2018. Review. PubMed PMID: 29675134; PubMed Central PMCID: PMC5841044.
Chopra S, Rathore A, Younas H, Pham LV, Gu C, Beselman A, Kim IY, Wolfe RR, Perin J, Polotsky VY, Jun JC. Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol During Sleep. J Clin Endocrinol Metab. 2017 Sep 1;102(9):3172-3181. doi: 10.1210/jc.2017-00619. PubMed PMID: 28595341; PubMed Central PMCID: PMC5587067.
Ayas NT, Drager LF, Morrell MJ, Polotsky VY. Update in Sleep-disordered Breathing 2016. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1561-1566. doi: 10.1164/rccm.201701-0048UP. Review. PubMed PMID: 28530119; PubMed Central PMCID: PMC5955019.
Pham LV, Miele CH, Schwartz NG, Arias RS, Rattner A, Gilman RH, Miranda JJ, Polotsky VY, Checkley W, Schwartz AR. Cardiometabolic correlates of sleep disordered breathing in Andean highlanders. Eur Respir J. 2017 Jun;49(6). doi: 10.1183/13993003.01705-2016. Print 2017 Jun. PubMed PMID: 28619952; PubMed Central PMCID: PMC5765983.
Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D. Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H808-H817. doi: 10.1152/ajpheart.00572.2016. Epub 2017 Feb 3. PubMed PMID: 28159808; PubMed Central PMCID: PMC5407165.
Shin MK, Han W, Joo H, Bevans-Fonti S, Shiota M, Stefanovski D, Polotsky VY. Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test. J Appl Physiol (1985). 2017 Apr 1;122(4):767-774. doi: 10.1152/japplphysiol.00975.2016. Epub 2017 Jan 19. PubMed PMID: 28104753; PubMed Central PMCID: PMC5407201.
Fleury Curado T, Fishbein K, Pho H, Brennick M, Dergacheva O, Sennes LU, Pham LV, Ladenheim EE, Spencer R, Mendelowitz D, Schwartz AR, Polotsky VY. Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency. Sci Rep. 2017 Mar 10;7:44392. doi: 10.1038/srep44392. PubMed PMID: 28281681; PubMed Central PMCID: PMC5345079.
Jun JC, Rathore A, Younas H, Gilkes D, Polotsky VY. Hypoxia-Inducible Factors and Cancer. Curr Sleep Med Rep. 2017 Mar;3(1):1-10. doi: 10.1007/s40675-017-0062-7. Epub 2017 Jan 28. PubMed PMID: 28944164; PubMed Central PMCID: PMC5607450.
Jun JC, Devera R, Unnikrishnan D, Shin MK, Bevans-Fonti S, Yao Q, Rathore A, Younas H, Halberg N, Scherer PE, Polotsky VY. Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis. J Mol Med (Berl). 2017 Mar;95(3):287-297. doi: 10.1007/s00109-016-1480-6. Epub 2016 Oct 14. PubMed PMID: 27738746; PubMed Central PMCID: PMC5322176.
Pham LV, Meinzen C, Arias RS, Schwartz NG, Rattner A, Miele CH, Smith PL, Schneider H, Miranda JJ, Gilman RH, Polotsky VY, Checkley W, Schwartz AR. Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders. High Alt Med Biol. 2017 Mar;18(1):11-19. doi: 10.1089/ham.2016.0102. PubMed PMID: 28306414; PubMed Central PMCID: PMC5361758.
Javaheri S, Barbe F, Campos-Rodriguez F, Dempsey JA, Khayat R, Javaheri S, Malhotra A, Martinez-Garcia MA, Mehra R, Pack AI, Polotsky VY, Redline S, Somers VK. Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences. J Am Coll Cardiol. 2017 Feb 21;69(7):841-858. doi: 10.1016/j.jacc.2016.11.069. Review. PubMed PMID: 28209226; PubMed Central PMCID: PMC5393905.
Mesarwi OA, Shin MK, Bevans-Fonti S, Schlesinger C, Shaw J, Polotsky VY. Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease. PLoS One. 2016;11(12):e0168572. doi: 10.1371/journal.pone.0168572. eCollection 2016. PubMed PMID: 28030556; PubMed Central PMCID: PMC5193414.
Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D. Direct projections from hypothalamic orexin neurons to brainstem cardiac vagal neurons. Neuroscience. 2016 Dec 17;339:47-53. doi: 10.1016/j.neuroscience.2016.09.038. Epub 2016 Sep 28. PubMed PMID: 27693474; PubMed Central PMCID: PMC5118111.
Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D. Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats. J Neurophysiol. 2016 Nov 1;116(5):2250-2259. doi: 10.1152/jn.00196.2016. Epub 2016 Aug 24. PubMed PMID: 27559138; PubMed Central PMCID: PMC5102318.
Zychowski KE, Sanchez B, Pedrosa RP, Lorenzi-Filho G, Drager LF, Polotsky VY, Campen MJ. Serum from obstructive sleep apnea patients induces inflammatory responses in coronary artery endothelial cells. Atherosclerosis. 2016 Nov;254:59-66. doi: 10.1016/j.atherosclerosis.2016.09.017. Epub 2016 Sep 22. PubMed PMID: 27693879; PubMed Central PMCID: PMC5097675.
Pham LV, Polotsky VY. Genome-Wide Association Studies in Obstructive Sleep Apnea. Will We Catch a Black Cat in a Dark Room?. Am J Respir Crit Care Med. 2016 Oct 1;194(7):789-791. doi: 10.1164/rccm.201603-0613ED. PubMed PMID: 27689706; PubMed Central PMCID: PMC5074656.
Llanos OL, Galiatsatos P, Guzmán-Vélez E, Patil SP, Smith PL, Magnuson T, Schweitzer M, Steele K, Polotsky VY, Schwartz AR. Pharyngeal collapsibility during sleep is elevated in insulin-resistant females with morbid obesity. Eur Respir J. 2016 Jun;47(6):1718-26. doi: 10.1183/13993003.00918-2015. Epub 2016 Apr 21. PubMed PMID: 27103392; PubMed Central PMCID: PMC5937533.
Miele CH, Schwartz AR, Gilman RH, Pham L, Wise RA, Davila-Roman VG, Jun JC, Polotsky VY, Miranda JJ, Leon-Velarde F, Checkley W. Increased Cardiometabolic Risk and Worsening Hypoxemia at High Altitude. High Alt Med Biol. 2016 Jun;17(2):93-100. doi: 10.1089/ham.2015.0084. PubMed PMID: 27281472; PubMed Central PMCID: PMC4913510.
Yao Q, Pho H, Kirkness J, Ladenheim EE, Bi S, Moran TH, Fuller DD, Schwartz AR, Polotsky VY. Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep. Sleep. 2016 May 1;39(5):1097-106. doi: 10.5665/sleep.5762. PubMed PMID: 26951402; PubMed Central PMCID: PMC4835308.
Chopra S, Polotsky VY, Jun JC. Sleep Apnea Research in Animals. Past, Present, and Future. Am J Respir Cell Mol Biol. 2016 Mar;54(3):299-305. doi: 10.1165/rcmb.2015-0218TR. Review. PubMed PMID: 26448201; PubMed Central PMCID: PMC4821036.
Jun JC, Polotsky VY. Stressful sleep. Eur Respir J. 2016 Feb;47(2):366-8. doi: 10.1183/13993003.01920-2015. PubMed PMID: 26828044; PubMed Central PMCID: PMC5686781.
Jun JC, Unnikrishnan D, Schneider H, Kirkness J, Schwartz AR, Smith PL, Polotsky VY. Effect of Acute Intermittent CPAP Depressurization during Sleep in Obese Patients. PLoS One. 2016;11(1):e0146606. doi: 10.1371/journal.pone.0146606. eCollection 2016. PubMed PMID: 26731735; PubMed Central PMCID: PMC4701426.
Pho H, Hernandez AB, Arias RS, Leitner EB, Van Kooten S, Kirkness JP, Schneider H, Smith PL, Polotsky VY, Schwartz AR. The effect of leptin replacement on sleep-disordered breathing in the leptin-deficient ob/ob mouse. J Appl Physiol (1985). 2016 Jan 1;120(1):78-86. doi: 10.1152/japplphysiol.00494.2015. Epub 2015 Oct 15. PubMed PMID: 26472867; PubMed Central PMCID: PMC4698442.
Polotsky VY, Bevans-Fonti S, Grigoryev DN, Punjabi NM. Intermittent Hypoxia Alters Gene Expression in Peripheral Blood Mononuclear Cells of Healthy Volunteers. PLoS One. 2015;10(12):e0144725. doi: 10.1371/journal.pone.0144725. eCollection 2015. PubMed PMID: 26657991; PubMed Central PMCID: PMC4684377.
Mesarwi OA, Shin MK, Drager LF, Bevans-Fonti S, Jun JC, Putcha N, Torbenson MS, Pedrosa RP, Lorenzi-Filho G, Steele KE, Schweitzer MA, Magnuson TH, Lidor AO, Schwartz AR, Polotsky VY. Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea. Sleep. 2015 Oct 1;38(10):1583-91. doi: 10.5665/sleep.5052. PubMed PMID: 26085300; PubMed Central PMCID: PMC4576332.
Drager LF, Polotsky VY, O'Donnell CP, Cravo SL, Lorenzi-Filho G, Machado BH. Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea. Am J Physiol Heart Circ Physiol. 2015 Oct;309(7):H1101-11. doi: 10.1152/ajpheart.00094.2015. Epub 2015 Jul 31. Review. PubMed PMID: 26232233; PubMed Central PMCID: PMC4816265.
Jun JC, Polotsky VY. Are we waking up to the effects of NEFA?. Diabetologia. 2015 Apr;58(4):651-3. doi: 10.1007/s00125-014-3489-0. Epub 2015 Jan 25. PubMed PMID: 25617999; PubMed Central PMCID: PMC4352391.
Unnikrishnan D, Jun J, Polotsky V. Inflammation in sleep apnea: an update. Rev Endocr Metab Disord. 2015 Mar;16(1):25-34. doi: 10.1007/s11154-014-9304-x. Review. PubMed PMID: 25502450; PubMed Central PMCID: PMC4346503.
Mesarwi OA, Sharma EV, Jun JC, Polotsky VY. Metabolic dysfunction in obstructive sleep apnea: A critical examination of underlying mechanisms. Sleep Biol Rhythms. 2015 Jan;13(1):2-17. doi: 10.1111/sbr.12078. PubMed PMID: 26412981; PubMed Central PMCID: PMC4583137.
Shirahata M, Tang WY, Shin MK, Polotsky VY. Is the Carotid Body a Metabolic Monitor?. Adv Exp Med Biol. 2015;860:153-9. doi: 10.1007/978-3-319-18440-1_17. PubMed PMID: 26303477; PubMed Central PMCID: PMC4793901.
Mesarwi OA, Ellenbogen JM, Polotsky VY. A patient with unusual electroencephalographic findings during rapid eye movement sleep. Ann Am Thorac Soc. 2014 Dec;11(10):1660-4. doi: 10.1513/AnnalsATS.201404-168CC. PubMed PMID: 25549034; PubMed Central PMCID: PMC5475426.
Jun JC, Shin MK, Devera R, Yao Q, Mesarwi O, Bevans-Fonti S, Polotsky VY. Intermittent hypoxia-induced glucose intolerance is abolished by α-adrenergic blockade or adrenal medullectomy. Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E1073-83. doi: 10.1152/ajpendo.00373.2014. Epub 2014 Oct 14. PubMed PMID: 25315697; PubMed Central PMCID: PMC4254988.
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