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Koury MJ, Haase VH. Deregulating iron-erythropoiesis regulation: transferrin receptor 2 as potential target for treating anemia in CKD. Kidney Int. 2023 Jul;104(1):25-28. doi: 10.1016/j.kint.2023.04.017. PubMed PMID: 37349056.
Ku E, Del Vecchio L, Eckardt KU, Haase VH, Johansen KL, Nangaku M, Tangri N, Waikar SS, Więcek A, Cheung M, Jadoul M, Winkelmayer WC, Wheeler DC. Novel Anemia Therapies in Chronic Kidney Disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2023 May 24;. doi: 10.1016/j.kint.2023.05.009. [Epub ahead of print] PubMed PMID: 37236424.
Song W, Postoak JL, Yang G, Guo X, Pua HH, Bader J, Rathmell JC, Kobayashi H, Haase VH, Leaptrot KL, Schrimpe-Rutledge AC, Sherrod SD, McLean JA, Zhang J, Wu L, Van Kaer L. Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2214874120. doi: 10.1073/pnas.2214874120. Epub 2022 Dec 27. PubMed PMID: 36574710; PubMed Central PMCID: PMC9910429.
Li J, Haase VH, Hao CM. Updates on Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors in the Treatment of Renal Anemia. Kidney Dis (Basel). 2023 Jan;9(1):1-11. doi: 10.1159/000527835. eCollection 2023 Jan. Review. PubMed PMID: 36756084; PubMed Central PMCID: PMC9900466.
Koury MJ, Agarwal R, Chertow GM, Eckardt KU, Fishbane S, Ganz T, Haase VH, Hanudel MR, Parfrey PS, Pergola PE, Roy-Chaudhury P, Tumlin JA, Anders R, Farag YMK, Luo W, Minga T, Solinsky C, Vargo DL, Winkelmayer WC. Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease. Am J Hematol. 2022 Sep;97(9):1178-1188. doi: 10.1002/ajh.26644. Epub 2022 Jul 15. PubMed PMID: 35751858; PubMed Central PMCID: PMC9543410.
Kobayashi H, Davidoff O, Pujari-Palmer S, Drevin M, Haase VH. EPO synthesis induced by HIF-PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non-injured nephron segments in murine kidney fibrosis. Acta Physiol (Oxf). 2022 Aug;235(4):e13826. doi: 10.1111/apha.13826. Epub 2022 May 18. PubMed PMID: 35491502; PubMed Central PMCID: PMC9329237.
Guan N, Kobayashi H, Ishii K, Davidoff O, Sha F, Ikizler TA, Hao CM, Chandel NS, Haase VH. Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Kidney Int. 2022 Jul;102(1):108-120. doi: 10.1016/j.kint.2022.02.030. Epub 2022 Mar 24. PubMed PMID: 35341793; PubMed Central PMCID: PMC9232975.
Clayton DB, Tong CMC, Li B, Taylor AS, De S, Mason MD, Dudley AG, Davidoff O, Kobayashi H, Haase VH. Inhibition of hypoxia-inducible factor-prolyl hydroxylation protects from cyclophosphamide-induced bladder injury and urinary dysfunction. Am J Physiol Renal Physiol. 2022 Jul 1;323(1):F81-F91. doi: 10.1152/ajprenal.00344.2021. Epub 2022 May 2. PubMed PMID: 35499237; PubMed Central PMCID: PMC9236868.
Haase VH. The ins and outs of ferric citrate. Kidney Int. 2022 Apr;101(4):668-670. doi: 10.1016/j.kint.2021.12.032. PubMed PMID: 35314048.
Burmakin M, Fasching A, Kobayashi H, Urrutia AA, Damdimopoulos A, Palm F, Haase VH. Pharmacological HIF-PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation. Acta Physiol (Oxf). 2021 Sep;233(1):e13668. doi: 10.1111/apha.13668. Epub 2021 May 15. PubMed PMID: 33900001.
Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB. Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney Int. 2021 Jun;99(6):1280-1295. doi: 10.1016/j.kint.2021.03.020. Epub 2021 Apr 8. PubMed PMID: 33839163.
Boothby MR, Raybuck A, Cho SH, Stengel KR, Haase VH, Hiebert S, Li J. Over-Generalizing About GC (Hypoxia): Pitfalls of Limiting Breadth of Experimental Systems and Analyses in Framing Informatics Conclusions. Front Immunol. 2021;12:664249. doi: 10.3389/fimmu.2021.664249. eCollection 2021. PubMed PMID: 34040610; PubMed Central PMCID: PMC8141812.
Haase VH. Hypoxia-inducible factor-prolyl hydroxylase inhibitors in the treatment of anemia of chronic kidney disease. Kidney Int Suppl (2011). 2021 Apr;11(1):8-25. doi: 10.1016/j.kisu.2020.12.002. Epub 2021 Mar 18. PubMed PMID: 33777492; PubMed Central PMCID: PMC7983025.
Zou J, Yang J, Zhu X, Zhong J, Elshaer A, Matsusaka T, Pastan I, Haase VH, Yang HC, Fogo AB. Stabilization of hypoxia-inducible factor ameliorates glomerular injury sensitization after tubulointerstitial injury. Kidney Int. 2021 Mar;99(3):620-631. doi: 10.1016/j.kint.2020.09.031. Epub 2020 Nov 1. PubMed PMID: 33137336; PubMed Central PMCID: PMC7914150.
Ishii K, Kobayashi H, Taguchi K, Guan N, Li A, Tong C, Davidoff O, Tran PV, Sharma M, Chandel NS, Kapp ME, Fogo AB, Brooks CR, Haase VH. Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease. Kidney Int. 2021 Mar;99(3):657-670. doi: 10.1016/j.kint.2020.10.013. Epub 2020 Nov 4. PubMed PMID: 33159962; PubMed Central PMCID: PMC8209657.
Urrutia AA, Guan N, Mesa-Ciller C, Afzal A, Davidoff O, Haase VH. Inactivation of HIF-prolyl 4-hydroxylases 1, 2 and 3 in NG2-expressing cells induces HIF2-mediated neurovascular expansion independent of erythropoietin. Acta Physiol (Oxf). 2021 Jan;231(1):e13547. doi: 10.1111/apha.13547. Epub 2020 Sep 22. PubMed PMID: 32846048; PubMed Central PMCID: PMC7757172.
Haase VH. Got glycogen? An energy resource in HIF-mediated prevention of ischemic kidney injury. Kidney Int. 2020 Apr;97(4):645-647. doi: 10.1016/j.kint.2019.11.036. PubMed PMID: 32200856.
Buell KG, Trumbo SP, Haase VH. A Unilateral Facial Rash with Eye Involvement. Am J Med. 2019 Jul;132(7):823-825. doi: 10.1016/j.amjmed.2019.02.007. Epub 2019 Mar 5. PubMed PMID: 30849384.
Sanghani NS, Haase VH. Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience. Adv Chronic Kidney Dis. 2019 Jul;26(4):253-266. doi: 10.1053/j.ackd.2019.04.004. Review. PubMed PMID: 31477256; PubMed Central PMCID: PMC7318915.
Cho SH, Raybuck AL, Blagih J, Kemboi E, Haase VH, Jones RG, Boothby MR. Hypoxia-inducible factors in CD4(+) T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8975-8984. doi: 10.1073/pnas.1811702116. Epub 2019 Apr 15. PubMed PMID: 30988188; PubMed Central PMCID: PMC6500120.
Haase VH. ARNT as a Novel Antifibrotic Target in CKD. Am J Kidney Dis. 2019 Feb;73(2):281-284. doi: 10.1053/j.ajkd.2018.08.009. Epub 2018 Oct 18. PubMed PMID: 30343956; PubMed Central PMCID: PMC6348016.
Haase VH, Chertow GM, Block GA, Pergola PE, deGoma EM, Khawaja Z, Sharma A, Maroni BJ, McCullough PA. Effects of vadadustat on hemoglobin concentrations in patients receiving hemodialysis previously treated with erythropoiesis-stimulating agents. Nephrol Dial Transplant. 2019 Jan 1;34(1):90-99. doi: 10.1093/ndt/gfy055. PubMed PMID: 29672740; PubMed Central PMCID: PMC6322440.
Kobayashi H, Liu J, Urrutia AA, Burmakin M, Ishii K, Rajan M, Davidoff O, Saifudeen Z, Haase VH. Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development. Kidney Int. 2017 Dec;92(6):1370-1383. doi: 10.1016/j.kint.2017.06.015. Epub 2017 Aug 26. PubMed PMID: 28847650; PubMed Central PMCID: PMC5696043.
Haase VH. Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies. Exp Cell Res. 2017 Jul 15;356(2):160-165. doi: 10.1016/j.yexcr.2017.05.004. Epub 2017 May 5. Review. PubMed PMID: 28483447; PubMed Central PMCID: PMC5507591.
Haase VH. HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism. Hemodial Int. 2017 Jun;21 Suppl 1(Suppl 1):S110-S124. doi: 10.1111/hdi.12567. Review. PubMed PMID: 28449418; PubMed Central PMCID: PMC5526677.
Stenvinkel P, Haase VH. Inflamed fat and mitochondrial dysfunction in end-stage renal disease links to hypoxia-could curcumin be of benefit?. Nephrol Dial Transplant. 2017 Jun 1;32(6):909-912. doi: 10.1093/ndt/gfx052. PubMed PMID: 28460128.
Haase VH. Oxygen sensors as therapeutic targets in kidney disease. Nephrol Ther. 2017 Apr;13 Suppl 1:S29-S34. doi: 10.1016/j.nephro.2017.01.015. Review. PubMed PMID: 28577740.
Urrutia AA, Afzal A, Nelson J, Davidoff O, Gross KW, Haase VH. Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes. Blood. 2016 Nov 24;128(21):2550-2560. doi: 10.1182/blood-2016-05-713545. Epub 2016 Sep 28. PubMed PMID: 27683416; PubMed Central PMCID: PMC5123193.
Pergola PE, Spinowitz BS, Hartman CS, Maroni BJ, Haase VH. Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease. Kidney Int. 2016 Nov;90(5):1115-1122. doi: 10.1016/j.kint.2016.07.019. Epub 2016 Sep 17. PubMed PMID: 27650732.
Cho SH, Raybuck AL, Stengel K, Wei M, Beck TC, Volanakis E, Thomas JW, Hiebert S, Haase VH, Boothby MR. Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system. Nature. 2016 Sep 8;537(7619):234-238. doi: 10.1038/nature19334. Epub 2016 Aug 8. PubMed PMID: 27501247; PubMed Central PMCID: PMC5161594.
Kapitsinou PP, Rajendran G, Astleford L, Michael M, Schonfeld MP, Fields T, Shay S, French JL, West J, Haase VH. The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice. Mol Cell Biol. 2016 May 15;36(10):1584-94. doi: 10.1128/MCB.01055-15. Print 2016 May 15. PubMed PMID: 26976644; PubMed Central PMCID: PMC4859687.
Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Invest. 2016 May 2;126(5):1926-38. doi: 10.1172/JCI83551. Epub 2016 Apr 18. PubMed PMID: 27088801; PubMed Central PMCID: PMC4855934.
Farsijani NM, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, Ikizler TA, O'Connor PM, Haase VH. Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. J Clin Invest. 2016 Apr 1;126(4):1425-37. doi: 10.1172/JCI74997. Epub 2016 Feb 29. PubMed PMID: 26927670; PubMed Central PMCID: PMC4811147.
Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1;310(3):L249-62. doi: 10.1152/ajplung.00258.2015. Epub 2015 Dec 4. PubMed PMID: 26637636; PubMed Central PMCID: PMC4838140.
Kapitsinou PP, Haase VH. Molecular mechanisms of ischemic preconditioning in the kidney. Am J Physiol Renal Physiol. 2015 Nov 15;309(10):F821-34. doi: 10.1152/ajprenal.00224.2015. Epub 2015 Aug 26. Review. PubMed PMID: 26311114; PubMed Central PMCID: PMC4652073.
Haase VH. Inflammation and hypoxia in the kidney: friends or foes?. Kidney Int. 2015 Aug;88(2):213-5. doi: 10.1038/ki.2015.89. PubMed PMID: 26230196; PubMed Central PMCID: PMC4534718.
Koury MJ, Haase VH. Anaemia in kidney disease: harnessing hypoxia responses for therapy. Nat Rev Nephrol. 2015 Jul;11(7):394-410. doi: 10.1038/nrneph.2015.82. Epub 2015 Jun 9. Review. PubMed PMID: 26055355; PubMed Central PMCID: PMC4497972.
Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15;308(12):F1452-62. doi: 10.1152/ajprenal.00066.2015. Epub 2015 Apr 29. PubMed PMID: 25925251; PubMed Central PMCID: PMC4469889.
Haase VH. A breath of fresh air for diabetic nephropathy. J Am Soc Nephrol. 2015 Feb;26(2):239-41. doi: 10.1681/ASN.2014080754. Epub 2014 Sep 2. PubMed PMID: 25183808; PubMed Central PMCID: PMC4310668.
Kapitsinou PP, Sano H, Michael M, Kobayashi H, Davidoff O, Bian A, Yao B, Zhang MZ, Harris RC, Duffy KJ, Erickson-Miller CL, Sutton TA, Haase VH. Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J Clin Invest. 2014 Jun;124(6):2396-409. doi: 10.1172/JCI69073. Epub 2014 May 1. PubMed PMID: 24789906; PubMed Central PMCID: PMC4092875.
Tak E, Ridyard D, Kim JH, Zimmerman M, Werner T, Wang XX, Shabeka U, Seo SW, Christians U, Klawitter J, Moldovan R, Garcia G, Levi M, Haase V, Ravid K, Eltzschig HK, Grenz A. CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J Am Soc Nephrol. 2014 Mar;25(3):547-63. doi: 10.1681/ASN.2012101014. Epub 2013 Nov 21. PubMed PMID: 24262796; PubMed Central PMCID: PMC3935577.
Lin Q, Huang Y, Booth CJ, Haase VH, Johnson RS, Celeste Simon M, Giordano FJ, Yun Z. Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy. J Am Heart Assoc. 2013 Dec 10;2(6):e000548. doi: 10.1161/JAHA.113.000548. PubMed PMID: 24326162; PubMed Central PMCID: PMC3886757.
Haase VH. Mechanisms of hypoxia responses in renal tissue. J Am Soc Nephrol. 2013 Mar;24(4):537-41. doi: 10.1681/ASN.2012080855. Epub 2013 Jan 18. Review. PubMed PMID: 23334390; NIHMSID:NIHMS454211.
Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev. 2013 Jan;27(1):41-53. doi: 10.1016/j.blre.2012.12.003. Epub 2013 Jan 3. Review. PubMed PMID: 23291219; PubMed Central PMCID: PMC3731139.
Liu Q, Davidoff O, Niss K, Haase VH. Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest. 2012 Dec;122(12):4635-44. doi: 10.1172/JCI63924. Epub 2012 Nov 1. PubMed PMID: 23114598; PubMed Central PMCID: PMC3533545.
Park SW, Kim M, Kim JY, Brown KM, Haase VH, D'Agati VD, Lee HT. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int. 2012 Oct;82(8):878-91. doi: 10.1038/ki.2012.224. Epub 2012 Jun 13. PubMed PMID: 22695326; PubMed Central PMCID: PMC3443517.
Haase VH. Hypoxia-inducible factor signaling in the development of kidney fibrosis. Fibrogenesis Tissue Repair. 2012;5(Suppl 1):S16. doi: 10.1186/1755-1536-5-S1-S16. eCollection 2012. PubMed PMID: 23259746; PubMed Central PMCID: PMC3368791.
Kobayashi H, Gilbert V, Liu Q, Kapitsinou PP, Unger TL, Rha J, Rivella S, Schlöndorff D, Haase VH. Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. J Immunol. 2012 May 15;188(10):5106-15. doi: 10.4049/jimmunol.1103377. Epub 2012 Apr 6. PubMed PMID: 22490864; PubMed Central PMCID: PMC3345098.
Haase VH. Renal cancer: oxygen meets metabolism. Exp Cell Res. 2012 May 15;318(9):1057-67. doi: 10.1016/j.yexcr.2012.02.026. Epub 2012 Mar 3. Review. PubMed PMID: 22406000; PubMed Central PMCID: PMC3334413.
Kapitsinou PP, Jaffe J, Michael M, Swan CE, Duffy KJ, Erickson-Miller CL, Haase VH. Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury. Am J Physiol Renal Physiol. 2012 May 1;302(9):F1172-9. doi: 10.1152/ajprenal.00667.2011. Epub 2012 Jan 18. PubMed PMID: 22262480; PubMed Central PMCID: PMC3362175.
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