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Kim TY, Kofron CM, King ME, Markes AR, Okundaye AO, Qu Z, Mende U, Choi BR. Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts. PLoS One. 2018;13(5):e0196714. doi: 10.1371/journal.pone.0196714. eCollection 2018. PubMed PMID: 29715271; PubMed Central PMCID: PMC5929561.
Jhun BS, O-Uchi J, Adaniya SM, Mancini TJ, Cao JL, King ME, Landi AK, Ma H, Shin M, Yang D, Xu X, Yoon Y, Choudhary G, Clements RT, Mende U, Sheu SS. Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes. J Physiol. 2018 Mar 1;596(5):827-855. doi: 10.1113/JP275418. Epub 2018 Jan 25. PubMed PMID: 29313986; PubMed Central PMCID: PMC5830422.
Kofron CM, Kim TY, King ME, Xie A, Feng F, Park E, Qu Z, Choi BR, Mende U. Gq-activated fibroblasts induce cardiomyocyte action potential prolongation and automaticity in a three-dimensional microtissue environment. Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H810-H827. doi: 10.1152/ajpheart.00181.2017. Epub 2017 Jul 14. PubMed PMID: 28710068; PubMed Central PMCID: PMC5668610.
Kofron CM, Mende U. In vitro models of the cardiac microenvironment to study myocyte and non-myocyte crosstalk: bioinspired approaches beyond the polystyrene dish. J Physiol. 2017 Jun 15;595(12):3891-3905. doi: 10.1113/JP273100. Epub 2017 Feb 27. Review. PubMed PMID: 28116799; PubMed Central PMCID: PMC5471366.
Czarnowska E, Bierła JB, Toczek M, Tyrankiewicz U, Pająk B, Domal-Kwiatkowska D, Ratajska A, Smoleński RT, Mende U, Chłopicki S. Narrow time window of metabolic changes associated with transition to overt heart failure in Tgaq*44 mice. Pharmacol Rep. 2016 Aug;68(4):707-14. doi: 10.1016/j.pharep.2016.03.013. Epub 2016 Mar 28. PubMed PMID: 27126697.
Zhang P, Kofron CM, Mende U. Heterotrimeric G protein-mediated signaling and its non-canonical regulation in the heart. Life Sci. 2015 May 15;129:35-41. doi: 10.1016/j.lfs.2015.02.029. Epub 2015 Mar 26. Review. PubMed PMID: 25818188; PubMed Central PMCID: PMC4415990.
Chichger H, Vang A, O'Connell KA, Zhang P, Mende U, Harrington EO, Choudhary G. PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L827-36. doi: 10.1152/ajplung.00184.2014. Epub 2015 Feb 6. PubMed PMID: 25659900; PubMed Central PMCID: PMC4398873.
Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M. Cardiac overexpression of constitutively active Galpha q causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice. PLoS One. 2014;9(8):e106354. doi: 10.1371/journal.pone.0106354. eCollection 2014. PubMed PMID: 25171374; PubMed Central PMCID: PMC4149533.
Zhang P, Mende U. Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart. Trends Cardiovasc Med. 2014 Feb;24(2):85-93. doi: 10.1016/j.tcm.2013.07.002. Epub 2013 Aug 17. Review. PubMed PMID: 23962825; PubMed Central PMCID: PMC3948174.
Zhang P, Su J, Mende U. Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences. Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1385-96. doi: 10.1152/ajpheart.01167.2011. Epub 2012 Oct 12. Review. PubMed PMID: 23064834; PubMed Central PMCID: PMC3532535.
Park-Windhol C, Zhang P, Zhu M, Su J, Chaves L Jr, Maldonado AE, King ME, Rickey L, Cullen D, Mende U. Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2. PLoS One. 2012;7(7):e40048. doi: 10.1371/journal.pone.0040048. Epub 2012 Jul 3. PubMed PMID: 22802950; PubMed Central PMCID: PMC3388988.
Desroches BR, Zhang P, Choi BR, King ME, Maldonado AE, Li W, Rago A, Liu G, Nath N, Hartmann KM, Yang B, Koren G, Morgan JR, Mende U. Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells. Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2031-42. doi: 10.1152/ajpheart.00743.2011. Epub 2012 Mar 16. PubMed PMID: 22427522; PubMed Central PMCID: PMC3362102.
Mackiewicz U, Czarnowska E, Brudek M, Pająk B, Duda M, Emanuel K, Csanyi G, Fedorowicz A, Grochal E, Tyrankiewicz U, Skórka T, Mende U, Lewartowski B, Chłopicki S. Preserved cardiomyocyte function and altered desmin pattern in transgenic mouse model of dilated cardiomyopathy. J Mol Cell Cardiol. 2012 May;52(5):978-87. doi: 10.1016/j.yjmcc.2012.01.008. Epub 2012 Jan 17. PubMed PMID: 22285482.
Pinz I, Zhu M, Mende U, Ingwall JS. An improved isolation procedure for adult mouse cardiomyocytes. Cell Biochem Biophys. 2011 Sep;61(1):93-101. doi: 10.1007/s12013-011-9165-9. PubMed PMID: 21327944; PubMed Central PMCID: PMC3249381.
Zhang P, Mende U. Regulators of G-protein signaling in the heart and their potential as therapeutic targets. Circ Res. 2011 Jul 22;109(3):320-33. doi: 10.1161/CIRCRESAHA.110.231423. Review. PubMed PMID: 21778436; PubMed Central PMCID: PMC3230557.
Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M. Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure. Circ J. 2011;75(10):2333-42. doi: 10.1253/circj.cj-10-1213. Epub 2011 Jul 20. PubMed PMID: 21778596.
Zhang P, Su J, King ME, Maldonado AE, Park C, Mende U. Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses. Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H147-56. doi: 10.1152/ajpheart.00026.2011. Epub 2011 Apr 15. PubMed PMID: 21498776; PubMed Central PMCID: PMC3129912.
Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP. RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol. 2011 Jun;50(6):1000-7. doi: 10.1016/j.yjmcc.2011.01.015. Epub 2011 Feb 1. PubMed PMID: 21291891; PubMed Central PMCID: PMC3743926.
Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M. Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice. Heart Rhythm. 2009 Jan;6(1):78-84. doi: 10.1016/j.hrthm.2008.10.018. Epub 2008 Oct 15. PubMed PMID: 19121805.
Drelicharz L, Kozlovski V, Skorka T, Heinze-Paluchowska S, Jasinski A, Gebska A, Guzik T, Olszanecki R, Wojnar L, Mende U, Csanyi G, Chlopicki S. NO and PGI(2) in coronary endothelial dysfunction in transgenic mice with dilated cardiomyopathy. Basic Res Cardiol. 2008 Sep;103(5):417-30. doi: 10.1007/s00395-008-0723-2. Epub 2008 Apr 22. PubMed PMID: 18431525.
Zhu M, Gach AA, Liu G, Xu X, Lim CC, Zhang JX, Mao L, Chuprun K, Koch WJ, Liao R, Koren G, Blaxall BC, Mende U. Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1335-47. doi: 10.1152/ajpheart.00584.2007. Epub 2008 Jan 11. PubMed PMID: 18192223.
Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Koyama Y, Goto K, Mende U, Kubota I. Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice. Circ J. 2008 Feb;72(2):309-17. doi: 10.1253/circj.72.309. PubMed PMID: 18219172.
Anger T, Klintworth N, Stumpf C, Daniel WG, Mende U, Garlichs CD. RGS protein specificity towards Gq- and Gi/o-mediated ERK 1/2 and Akt activation, in vitro. J Biochem Mol Biol. 2007 Nov 30;40(6):899-910. doi: 10.5483/bmbrep.2007.40.6.899. PubMed PMID: 18047785.
Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto YM, Liao R, Jain MK. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7074-9. doi: 10.1073/pnas.0701981104. Epub 2007 Apr 16. PubMed PMID: 17438289; PubMed Central PMCID: PMC1855421.
Schmitt JP, Debold EP, Ahmad F, Armstrong A, Frederico A, Conner DA, Mende U, Lohse MJ, Warshaw D, Seidman CE, Seidman JG. Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14525-30. doi: 10.1073/pnas.0606383103. Epub 2006 Sep 18. PubMed PMID: 16983074; PubMed Central PMCID: PMC1599993.
Hao J, Michalek C, Zhang W, Zhu M, Xu X, Mende U. Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation. J Mol Cell Cardiol. 2006 Jul;41(1):51-61. doi: 10.1016/j.yjmcc.2006.04.003. Epub 2006 Jun 6. PubMed PMID: 16756988.
Zhang W, Anger T, Su J, Hao J, Xu X, Zhu M, Gach A, Cui L, Liao R, Mende U. Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. J Biol Chem. 2006 Mar 3;281(9):5811-20. doi: 10.1074/jbc.M507871200. Epub 2005 Dec 26. PubMed PMID: 16380388.
Carvalho-Bianco SD, Kim BW, Zhang JX, Harney JW, Ribeiro RS, Gereben B, Bianco AC, Mende U, Larsen PR. Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness. Mol Endocrinol. 2004 Jul;18(7):1840-9. doi: 10.1210/me.2003-0125. Epub 2004 May 6. PubMed PMID: 15131256.
Anger T, Zhang W, Mende U. Differential contribution of GTPase activation and effector antagonism to the inhibitory effect of RGS proteins on Gq-mediated signaling in vivo. J Biol Chem. 2004 Feb 6;279(6):3906-15. doi: 10.1074/jbc.M309496200. Epub 2003 Nov 20. PubMed PMID: 14630933.
Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U, Kranias EG, MacLennan DH, Seidman JG, Seidman CE. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science. 2003 Feb 28;299(5611):1410-3. doi: 10.1126/science.1081578. PubMed PMID: 12610310.
Semsarian C, Ahmad I, Giewat M, Georgakopoulos D, Schmitt JP, McConnell BK, Reiken S, Mende U, Marks AR, Kass DA, Seidman CE, Seidman JG. The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest. 2002 Apr;109(8):1013-20. doi: 10.1172/JCI14677. PubMed PMID: 11956238; PubMed Central PMCID: PMC150949.
Gehrmann J, Meister M, Maguire CT, Martins DC, Hammer PE, Neer EJ, Berul CI, Mende U. Impaired parasympathetic heart rate control in mice with a reduction of functional G protein betagamma-subunits. Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H445-56. doi: 10.1152/ajpheart.00565.2001. PubMed PMID: 11788391.
Mende U, Semsarian C, Martins DC, Kagen A, Duffy C, Schoen FJ, Neer EJ. Dilated cardiomyopathy in two transgenic mouse lines expressing activated G protein alpha(q): lack of correlation between phospholipase C activation and the phenotype. J Mol Cell Cardiol. 2001 Aug;33(8):1477-91. doi: 10.1006/jmcc.2001.1411. PubMed PMID: 11448136.
Greif GJ, Sodickson DL, Bean BP, Neer EJ, Mende U. Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o). J Neurophysiol. 2000 Feb;83(2):1010-8. doi: 10.1152/jn.2000.83.2.1010. PubMed PMID: 10669512.
Mende U, Kagen A, Meister M, Neer EJ. Signal transduction in atria and ventricles of mice with transient cardiac expression of activated G protein alpha(q). Circ Res. 1999 Nov 26;85(11):1085-91. doi: 10.1161/01.res.85.11.1085. PubMed PMID: 10571540.
Mende U, Kagen A, Cohen A, Aramburu J, Schoen FJ, Neer EJ. Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13893-8. doi: 10.1073/pnas.95.23.13893. PubMed PMID: 9811897; PubMed Central PMCID: PMC24952.
Mende U, Zagrovic B, Cohen A, Li Y, Valenzuela D, Fishman MC, Neer EJ. Effect of deletion of the major brain G-protein alpha subunit (alpha(o)) on coordination of G-protein subunits and on adenylyl cyclase activity. J Neurosci Res. 1998 Oct 15;54(2):263-72. doi: 10.1002/(SICI)1097-4547(19981015)54:2<263::AID-JNR14>3.0.CO;2-5. PubMed PMID: 9788285.
Valenzuela D, Han X, Mende U, Fankhauser C, Mashimo H, Huang P, Pfeffer J, Neer EJ, Fishman MC. G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1727-32. doi: 10.1073/pnas.94.5.1727. PubMed PMID: 9050846; PubMed Central PMCID: PMC19984.
Li Y, Mende U, Lewis C, Neer EJ. Maintenance of cellular levels of G-proteins: different efficiencies of alpha s and alpha o synthesis in GH3 cells. Biochem J. 1996 Sep 15;318 ( Pt 3):1071-7. doi: 10.1042/bj3181071. PubMed PMID: 8836158; PubMed Central PMCID: PMC1217725.
Bartel S, Stein B, Eschenhagen T, Mende U, Neumann J, Schmitz W, Krause EG, Karczewski P, Scholz H. Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts. Mol Cell Biochem. 1996 Apr 12-26;157(1-2):171-9. doi: 10.1007/bf00227896. PubMed PMID: 8739244.
Eschenhagen T, Mende U, Diederich M, Hertle B, Memmesheimer C, Pohl A, Schmitz W, Scholz H, Steinfath M, Böhm M, Michel MC, Brodde OE, Raap A. Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia. Circulation. 1996 Feb 15;93(4):763-71. doi: 10.1161/01.cir.93.4.763. PubMed PMID: 8641006.
Stokke M, Hagelin EM, Mende U, Brørs O. Stable guanosine 5'-triphosphate-analogues inhibit specific (+)-[3H]isradipine binding in rat hearts by a Ca(2+)-lowering, G protein-independent mechanism. Pharmacol Toxicol. 1996 Jan;78(1):28-36. doi: 10.1111/j.1600-0773.1996.tb00176.x. PubMed PMID: 8685083.
Boluyt MO, Long X, Eschenhagen T, Mende U, Schmitz W, Crow MT, Lakatta EG. Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart. Am J Physiol. 1995 Aug;269(2 Pt 2):H638-47. doi: 10.1152/ajpheart.1995.269.2.H638. PubMed PMID: 7653628.
Mende U, Schmidt CJ, Yi F, Spring DJ, Neer EJ. The G protein gamma subunit. Requirements for dimerization with beta subunits. J Biol Chem. 1995 Jun 30;270(26):15892-8. doi: 10.1074/jbc.270.26.15892. PubMed PMID: 7541050.
Jakob H, Sigmund M, Eschenhagen T, Mende U, Patten M, Schmitz W, Scholz H, Schulte am Esch J, Steinfath M, Hanrath P. Effect of captopril on myocardial beta-adrenoceptor density and Gi alpha-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy. Eur J Clin Pharmacol. 1995;47(5):389-94. doi: 10.1007/bf00196850. PubMed PMID: 7720758.
von Schrenck T, Mackensen B, Mende U, Schmitz W, Sievers J, Mirau S, Raedler A, Greten H. Signal transduction pathway of the muscarinic receptors mediating gallbladder contraction. Naunyn Schmiedebergs Arch Pharmacol. 1994 Apr;349(4):346-54. doi: 10.1007/bf00170879. PubMed PMID: 8058106.
Böhm M, Eschenhagen T, Gierschik P, Larisch K, Lensche H, Mende U, Schmitz W, Schnabel P, Scholz H, Steinfath M. Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure. J Mol Cell Cardiol. 1994 Feb;26(2):133-49. doi: 10.1006/jmcc.1994.1017. PubMed PMID: 8006975.
Stein B, Mende U, Neumann J, Schmitz W, Scholz H. Pertussis toxin unmasks stimulatory myocardial A2-adenosine receptors on ventricular cardiomyocytes. J Mol Cell Cardiol. 1993 Jun;25(6):655-9. doi: 10.1006/jmcc.1993.1078. PubMed PMID: 8411191.
Eschenhagen T, Mende U, Diederich M, Nose M, Schmitz W, Scholz H, Schulte am Esch J, Warnholtz A, Schäfer H. Long term beta-adrenoceptor-mediated up-regulation of Gi alpha and G(o) alpha mRNA levels and pertussis toxin-sensitive guanine nucleotide-binding proteins in rat heart. Mol Pharmacol. 1992 Nov;42(5):773-83. PubMed PMID: 1331760.
Bethke T, Eschenhagen T, Klimkiewicz A, Kohl C, von der Leyen H, Mehl H, Mende U, Meyer W, Neumann J, Rosswag S. Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts. Arzneimittelforschung. 1992 Apr;42(4):437-45. PubMed PMID: 1386515.
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