My Bibliography

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Levy JL, Mirek ET, Rodriguez EM, Tolentino MJ, Zalma BA, Roepke TA, Wek RC, Cao R, Anthony TG. GCN2 drives diurnal patterns in the hepatic integrated stress response and maintains circadian rhythms in whole body metabolism during amino acid insufficiency. Am J Physiol Endocrinol Metab. 2024 Oct 1;327(4):E563-E576. doi: 10.1152/ajpendo.00129.2024. Epub 2024 Aug 28. PubMed PMID: 39196798; PubMed Central PMCID: PMC11482268.

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Li Y, Lu L, Levy JL, Anthony TG, Androulakis IP. Computational modeling of the synergistic role of GCN2 and the HPA axis in regulating the integrated stress response in the central circadian timing system. Physiol Genomics. 2024 Aug 1;56(8):531-543. doi: 10.1152/physiolgenomics.00030.2024. Epub 2024 Jun 17. PubMed PMID: 38881429.

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Bowman CE, Neinast MD, Jang C, Patel J, Blair MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z. Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK. bioRxiv. 2024 Mar 10;. doi: 10.1101/2024.03.05.582974. PubMed PMID: 38496495; PubMed Central PMCID: PMC10942310.

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Misra J, Carlson KR, Spandau DF, Wek RC. Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions. Nucleic Acids Res. 2024 Feb 28;52(4):1830-1846. doi: 10.1093/nar/gkae006. PubMed PMID: 38281137; PubMed Central PMCID: PMC10899773.

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Levy JL, Mirek ET, Rodriguez EM, Zalma B, Burns J, Jonsson WO, Sampath H, Staschke KA, Wek RC, Anthony TG. GCN2 is required to maintain core body temperature in mice during acute cold. Am J Physiol Endocrinol Metab. 2023 Nov 1;325(5):E624-E637. doi: 10.1152/ajpendo.00181.2023. Epub 2023 Oct 4. PubMed PMID: 37792040; PubMed Central PMCID: PMC10864021.

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Lin H, Naveed M, Hansen A, Anthony TG, Cao R. The Antihypertensive Guanabenz Exacerbates Integrated Stress Response and Disrupts the Brain Circadian Clock. Clocks Sleep. 2023 Oct 31;5(4):639-650. doi: 10.3390/clockssleep5040043. PubMed PMID: 37987394; PubMed Central PMCID: PMC10660470.

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Jonsson WO, Borowik AK, Pranay A, Kinter MT, Mirek ET, Levy JL, Snyder EM, Miller BF, Anthony TG. Kinetic proteomics identifies targeted changes in liver metabolism and the ribo-interactome by dietary sulfur amino acid restriction. Geroscience. 2023 Aug;45(4):2425-2441. doi: 10.1007/s11357-023-00758-w. Epub 2023 Mar 28. PubMed PMID: 36976488; PubMed Central PMCID: PMC10651627.

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Wek RC, Anthony TG, Staschke KA. Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response. Antioxid Redox Signal. 2023 Aug;39(4-6):351-373. doi: 10.1089/ars.2022.0123. Epub 2023 May 9. Review. PubMed PMID: 36943285; PubMed Central PMCID: PMC10443206.

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Ferrer M, Anthony TG, Ayres JS, Biffi G, Brown JC, Caan BJ, Cespedes Feliciano EM, Coll AP, Dunne RF, Goncalves MD, Grethlein J, Heymsfield SB, Hui S, Jamal-Hanjani M, Lam JM, Lewis DY, McCandlish D, Mustian KM, O'Rahilly S, Perrimon N, White EP, Janowitz T. Cachexia: A systemic consequence of progressive, unresolved disease. Cell. 2023 Apr 27;186(9):1824-1845. doi: 10.1016/j.cell.2023.03.028. Review. PubMed PMID: 37116469; PubMed Central PMCID: PMC11059056.

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Carlson KR, Georgiadis MM, Tameire F, Staschke KA, Wek RC. Activation of Gcn2 by small molecules designed to be inhibitors. J Biol Chem. 2023 Apr;299(4):104595. doi: 10.1016/j.jbc.2023.104595. Epub 2023 Mar 8. PubMed PMID: 36898579; PubMed Central PMCID: PMC10124904.

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Tsai CY, Saito T, Sarangdhar M, Abu-El-Haija M, Wen L, Lee B, Yu M, Lipata DA, Manohar M, Barakat MT, Contrepois K, Tran TH, Theoret Y, Bo N, Ding Y, Stevenson K, Ladas EJ, Silverman LB, Quadro L, Anthony TG, Jegga AG, Husain SZ. A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis. Sci Transl Med. 2023 Mar 15;15(687):eabn2110. doi: 10.1126/scitranslmed.abn2110. Epub 2023 Mar 15. PubMed PMID: 36921036; PubMed Central PMCID: PMC10205044.

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Amin PH, Carlson KR, Wek RC. An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response. J Biol Chem. 2023 Feb;299(2):102864. doi: 10.1016/j.jbc.2022.102864. Epub 2022 Dec 31. PubMed PMID: 36596357; PubMed Central PMCID: PMC9971878.

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Pellegrino JK, Anthony TG, Gillies P, Arent SM. The exercise metabolome: acute aerobic and anaerobic signatures. J Int Soc Sports Nutr. 2022;19(1):603-622. doi: 10.1080/15502783.2022.2115858. eCollection 2022. PubMed PMID: 36250148; PubMed Central PMCID: PMC9559054.

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Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, Wek RC, Staschke KA. GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis. Elife. 2022 Sep 15;11. doi: 10.7554/eLife.81083. PubMed PMID: 36107759; PubMed Central PMCID: PMC9578714.

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Martinez W, Zhang Q, Linden MA, Schacher N, Darvish S, Mirek ET, Levy JL, Jonsson WO, Anthony TG, Hamilton KL. Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction. Front Aging. 2022;3:975129. doi: 10.3389/fragi.2022.975129. eCollection 2022. PubMed PMID: 36091469; PubMed Central PMCID: PMC9450999.

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Jonsson WO, Mirek ET, Wek RC, Anthony TG. Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific. FASEB J. 2022 Jul;36(7):e22396. doi: 10.1096/fj.202200204RR. PubMed PMID: 35690926; PubMed Central PMCID: PMC9204950.

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Ebert SM, Rasmussen BB, Judge AR, Judge SM, Larsson L, Wek RC, Anthony TG, Marcotte GR, Miller MJ, Yorek MA, Vella A, Volpi E, Stern JI, Strub MD, Ryan Z, Talley JJ, Adams CM. Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. J Nutr. 2022 Apr 1;152(4):926-938. doi: 10.1093/jn/nxab440. Review. PubMed PMID: 34958390; PubMed Central PMCID: PMC8970988.

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Nofal M, Wang T, Yang L, Jankowski CSR, Hsin-Jung Li S, Han S, Parsons L, Frese AN, Gitai Z, Anthony TG, Wühr M, Sabatini DM, Rabinowitz JD. GCN2 adapts protein synthesis to scavenging-dependent growth. Cell Syst. 2022 Feb 16;13(2):158-172.e9. doi: 10.1016/j.cels.2021.09.014. Epub 2021 Oct 26. PubMed PMID: 34706266; PubMed Central PMCID: PMC8961722.

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Li X, Hui S, Mirek ET, Jonsson WO, Anthony TG, Lee WD, Zeng X, Jang C, Rabinowitz JD. Circulating metabolite homeostasis achieved through mass action. Nat Metab. 2022 Jan;4(1):141-152. doi: 10.1038/s42255-021-00517-1. Epub 2022 Jan 20. PubMed PMID: 35058631; PubMed Central PMCID: PMC9244777.

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Misra J, Holmes MJ, T Mirek E, Langevin M, Kim HG, Carlson KR, Watford M, Dong XC, Anthony TG, Wek RC. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Res. 2021 Jun 4;49(10):5726-5742. doi: 10.1093/nar/gkab362. PubMed PMID: 34023907; PubMed Central PMCID: PMC8191763.

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Jonsson WO, Margolies NS, Mirek ET, Zhang Q, Linden MA, Hill CM, Link C, Bithi N, Zalma B, Levy JL, Pettit AP, Miller JW, Hine C, Morrison CD, Gettys TW, Miller BF, Hamilton KL, Wek RC, Anthony TG. Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex. J Nutr. 2021 Apr 8;151(4):785-799. doi: 10.1093/jn/nxaa396. PubMed PMID: 33512502; PubMed Central PMCID: PMC8030708.

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Klein DJ, Anthony TG, McKeever KH. Metabolomics in equine sport and exercise. J Anim Physiol Anim Nutr (Berl). 2021 Jan;105(1):140-148. doi: 10.1111/jpn.13384. Epub 2020 Jun 8. Review. PubMed PMID: 32511844.

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Lackey AI, Chen T, Zhou YX, Bottasso Arias NM, Doran JM, Zacharisen SM, Gajda AM, Jonsson WO, Córsico B, Anthony TG, Joseph LB, Storch J. Mechanisms underlying reduced weight gain in intestinal fatty acid-binding protein (IFABP) null mice. Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G518-G530. doi: 10.1152/ajpgi.00120.2019. Epub 2020 Jan 6. PubMed PMID: 31905021; PubMed Central PMCID: PMC7099495.

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Klein DJ, McKeever KH, Mirek ET, Anthony TG. Metabolomic Response of Equine Skeletal Muscle to Acute Fatiguing Exercise and Training. Front Physiol. 2020;11:110. doi: 10.3389/fphys.2020.00110. eCollection 2020. PubMed PMID: 32132934; PubMed Central PMCID: PMC7040365.

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Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson DA, Zong WX. Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell Rep. 2019 Oct 29;29(5):1287-1298.e6. doi: 10.1016/j.celrep.2019.09.056. PubMed PMID: 31665640; PubMed Central PMCID: PMC6886125.

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Park J, Zhu Q, Mirek E, Na L, Raduwan H, Anthony TG, Belden WJ. BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin. PLoS One. 2019;14(10):e0223803. doi: 10.1371/journal.pone.0223803. eCollection 2019. PubMed PMID: 31634367; PubMed Central PMCID: PMC6802832.

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Nikonorova IA, Zhu Q, Signore CC, Mirek ET, Jonsson WO, Kong B, Guo GL, Belden WJ, Anthony TG. Age modulates liver responses to asparaginase-induced amino acid stress in mice. J Biol Chem. 2019 Sep 20;294(38):13864-13875. doi: 10.1074/jbc.RA119.009864. Epub 2019 Aug 14. PubMed PMID: 31413113; PubMed Central PMCID: PMC6755797.

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Jonsson WO, Margolies NS, Anthony TG. Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights. Nutrients. 2019 Jun 15;11(6). doi: 10.3390/nu11061349. Review. PubMed PMID: 31208042; PubMed Central PMCID: PMC6627990.

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Neinast MD, Jang C, Hui S, Murashige DS, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z. Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell Metab. 2019 Feb 5;29(2):417-429.e4. doi: 10.1016/j.cmet.2018.10.013. Epub 2018 Nov 15. PubMed PMID: 30449684; PubMed Central PMCID: PMC6365191.

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Yimcharoen M, Kittikunnathum S, Suknikorn C, Nak-On W, Yeethong P, Anthony TG, Bunpo P. Effects of ascorbic acid supplementation on oxidative stress markers in healthy women following a single bout of exercise. J Int Soc Sports Nutr. 2019 Jan 21;16(1):2. doi: 10.1186/s12970-019-0269-8. PubMed PMID: 30665439; PubMed Central PMCID: PMC6341721.

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Tuazon MA, Campbell SC, Klein DJ, Shapses SA, Anacker KR, Anthony TG, Uzumcu M, Henderson GC. Effects of ovariectomy and exercise training intensity on energy substrate and hepatic lipid metabolism, and spontaneous physical activity in mice. Metabolism. 2018 Jun;83:234-244. doi: 10.1016/j.metabol.2018.02.011. Epub 2018 Mar 6. PubMed PMID: 29522773.

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Nikonorova IA, Mirek ET, Signore CC, Goudie MP, Wek RC, Anthony TG. Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver. J Biol Chem. 2018 Apr 6;293(14):5005-5015. doi: 10.1074/jbc.RA117.001625. Epub 2018 Feb 15. PubMed PMID: 29449374; PubMed Central PMCID: PMC5892569.

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Willy JA, Young SK, Mosley AL, Gawrieh S, Stevens JL, Masuoka HC, Wek RC. Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response. J Biol Chem. 2017 Aug 25;292(34):14050-14065. doi: 10.1074/jbc.M117.799304. Epub 2017 Jul 14. PubMed PMID: 28710282; PubMed Central PMCID: PMC5572902.

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Pettit AP, Jonsson WO, Bargoud AR, Mirek ET, Peelor FF 3rd, Wang Y, Gettys TW, Kimball SR, Miller BF, Hamilton KL, Wek RC, Anthony TG. Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice. J Nutr. 2017 Jun;147(6):1031-1040. doi: 10.3945/jn.116.246710. Epub 2017 Apr 26. PubMed PMID: 28446632; PubMed Central PMCID: PMC5443467.

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Al-Baghdadi RJT, Nikonorova IA, Mirek ET, Wang Y, Park J, Belden WJ, Wek RC, Anthony TG. Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase. Sci Rep. 2017 Apr 28;7(1):1272. doi: 10.1038/s41598-017-01041-7. PubMed PMID: 28455513; PubMed Central PMCID: PMC5430736.

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Nikonorova IA, Al-Baghdadi RJT, Mirek ET, Wang Y, Goudie MP, Wetstein BB, Dixon JL, Hine C, Mitchell JR, Adams CM, Wek RC, Anthony TG. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice. J Biol Chem. 2017 Apr 21;292(16):6786-6798. doi: 10.1074/jbc.M116.768408. Epub 2017 Feb 27. PubMed PMID: 28242759; PubMed Central PMCID: PMC5399125.

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Gietzen DW, Anthony TG, Fafournoux P, Maurin AC, Koehnle TJ, Hao S. Measuring the Ability of Mice to Sense Dietary Essential Amino Acid Deficiency: The Importance of Amino Acid Status and Timing. Cell Rep. 2016 Aug 23;16(8):2049-2050. doi: 10.1016/j.celrep.2016.08.021. PubMed PMID: 27558824.

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Anthony TG. Mechanisms of protein balance in skeletal muscle. Domest Anim Endocrinol. 2016 Jul;56 Suppl(Suppl):S23-32. doi: 10.1016/j.domaniend.2016.02.012. Review. PubMed PMID: 27345321; PubMed Central PMCID: PMC4926040.

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Phillipson-Weiner L, Mirek ET, Wang Y, McAuliffe WG, Wek RC, Anthony TG. General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1061-70. doi: 10.1152/ajpgi.00052.2016. Epub 2016 Mar 11. PubMed PMID: 26968207; PubMed Central PMCID: PMC4935488.

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Wanders D, Stone KP, Forney LA, Cortez CC, Dille KN, Simon J, Xu M, Hotard EC, Nikonorova IA, Pettit AP, Anthony TG, Gettys TW. Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction. Diabetes. 2016 Jun;65(6):1499-510. doi: 10.2337/db15-1324. Epub 2016 Mar 2. PubMed PMID: 26936965; PubMed Central PMCID: PMC4878423.

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Fusakio ME, Willy JA, Wang Y, Mirek ET, Al Baghdadi RJ, Adams CM, Anthony TG, Wek RC. Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver. Mol Biol Cell. 2016 May 1;27(9):1536-51. doi: 10.1091/mbc.E16-01-0039. Epub 2016 Mar 9. PubMed PMID: 26960794; PubMed Central PMCID: PMC4850040.

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Bunpo P, Anthony TG. Ascorbic acid supplementation does not alter oxidative stress markers in healthy volunteers engaged in a supervised exercise program. Appl Physiol Nutr Metab. 2016 Feb;41(2):175-80. doi: 10.1139/apnm-2015-0285. Epub 2015 Oct 26. PubMed PMID: 26789096.

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Duan Y, Li F, Li Y, Tang Y, Kong X, Feng Z, Anthony TG, Watford M, Hou Y, Wu G, Yin Y. The role of leucine and its metabolites in protein and energy metabolism. Amino Acids. 2016 Jan;48(1):41-51. doi: 10.1007/s00726-015-2067-1. Epub 2015 Aug 9. Review. PubMed PMID: 26255285.

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Anthony TG, Mirek ET, Bargoud AR, Phillipson-Weiner L, DeOliveira CM, Wetstein B, Graf BL, Kuhn PE, Raskin I. Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats. Appl Physiol Nutr Metab. 2015 Dec;40(12):1324-8. doi: 10.1139/apnm-2015-0301. Epub 2015 Sep 17. PubMed PMID: 26584207.

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Anthony TG. Homeostatic responses to amino acid insufficiency. Anim Nutr. 2015 Sep;1(3):135-137. doi: 10.1016/j.aninu.2015.10.001. Epub 2015 Oct 24. Review. PubMed PMID: 29767147; PubMed Central PMCID: PMC5945978.

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Layman DK, Anthony TG, Rasmussen BB, Adams SH, Lynch CJ, Brinkworth GD, Davis TA. Defining meal requirements for protein to optimize metabolic roles of amino acids. Am J Clin Nutr. 2015 Jun;101(6):1330S-1338S. doi: 10.3945/ajcn.114.084053. Epub 2015 Apr 29. PubMed PMID: 25926513; PubMed Central PMCID: PMC5278948.

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Wilson GJ, Lennox BA, She P, Mirek ET, Al Baghdadi RJ, Fusakio ME, Dixon JL, Henderson GC, Wek RC, Anthony TG. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E283-93. doi: 10.1152/ajpendo.00361.2014. Epub 2014 Dec 9. PubMed PMID: 25491724; PubMed Central PMCID: PMC4329494.

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Tuazon MA, McConnell TR, Wilson GJ, Anthony TG, Henderson GC. Intensity-dependent and sex-specific alterations in hepatic triglyceride metabolism in mice following acute exercise. J Appl Physiol (1985). 2015 Jan 1;118(1):61-70. doi: 10.1152/japplphysiol.00440.2014. Epub 2014 Sep 25. PubMed PMID: 25257878; PubMed Central PMCID: PMC6195669.

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Baird TD, Palam LR, Fusakio ME, Willy JA, Davis CM, McClintick JN, Anthony TG, Wek RC. Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα. Mol Biol Cell. 2014 May;25(10):1686-97. doi: 10.1091/mbc.E14-02-0704. Epub 2014 Mar 19. PubMed PMID: 24648495; PubMed Central PMCID: PMC4019499.

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Wilson GJ, Bunpo P, Cundiff JK, Wek RC, Anthony TG. The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1124-33. doi: 10.1152/ajpendo.00080.2013. Epub 2013 Sep 3. PubMed PMID: 24002574; PubMed Central PMCID: PMC3840205.