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Griffin TM, Scanzello CR. Innate inflammation and synovial macrophages in osteoarthritis pathophysiology. Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):57-63. Epub 2019 Oct 15. Review. PubMed PMID: 31621560; PubMed Central PMCID: PMC6842324.
Zhu S, Makosa D, Miller B, Griffin TM. Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis. Connect Tissue Res. 2019 Sep 15;:1-14. doi: 10.1080/03008207.2019.1665035. [Epub ahead of print] PubMed PMID: 31522568; NIHMSID:NIHMS1540137.
Kalaitzoglou E, Lopes EBP, Fu Y, Herron JC, Flaming JM, Donovan EL, Hu Y, Filiberti A, Griffin TM, Humphrey MB. TLR4 Promotes and DAP12 Limits Obesity-Induced Osteoarthritis in Aged Female Mice. JBMR Plus. 2019 Apr;3(4):e10079. doi: 10.1002/jbm4.10079. eCollection 2019 Apr. PubMed PMID: 31044181; PubMed Central PMCID: PMC6478583.
Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H. Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):411-428. doi: 10.1002/jcsm.12375. Epub 2019 Feb 1. PubMed PMID: 30706998; PubMed Central PMCID: PMC6463475.
Sivasami P, Poudel N, Munteanu MC, Hudson J, Lovern P, Liu L, Griffin T, Hinsdale ME. Adipose tissue loss and lipodystrophy in xylosyltransferase II deficient mice. Int J Obes (Lond). 2019 Feb 18;. doi: 10.1038/s41366-019-0324-1. [Epub ahead of print] PubMed PMID: 30778123.
Batushansky A, Matsuzaki S, Newhardt MF, West MS, Griffin TM, Humphries KM. GC-MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting. Metabolomics. 2019 Jan 28;15(2):18. doi: 10.1007/s11306-019-1478-5. PubMed PMID: 30830475; PubMed Central PMCID: PMC6478396.
Donovan EL, Lopes EBP, Batushansky A, Kinter M, Griffin TM. Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice. Dis Model Mech. 2018 Aug 31;11(9). doi: 10.1242/dmm.034827. PubMed PMID: 30018076; PubMed Central PMCID: PMC6176996.
Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS. Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep. 2018 Mar;19(3). doi: 10.15252/embr.201745009. Epub 2018 Feb 2. PubMed PMID: 29420235; PubMed Central PMCID: PMC5836096.
Issa R, Boeving M, Kinter M, Griffin TM. Effect of biomechanical stress on endogenous antioxidant networks in bovine articular cartilage. J Orthop Res. 2018 Feb;36(2):760-769. doi: 10.1002/jor.23728. Epub 2017 Oct 17. PubMed PMID: 28892196; PubMed Central PMCID: PMC5839935.
He C, Medley SC, Kim J, Sun C, Kwon HR, Sakashita H, Pincu Y, Yao L, Eppard D, Dai B, Berry WL, Griffin TM, Olson LE. STAT1 modulates tissue wasting or overgrowth downstream from PDGFRβ. Genes Dev. 2017 Aug 15;31(16):1666-1678. doi: 10.1101/gad.300384.117. Epub 2017 Sep 18. PubMed PMID: 28924035; PubMed Central PMCID: PMC5647937.
Kalaitzoglou E, Griffin TM, Humphrey MB. Innate Immune Responses and Osteoarthritis. Curr Rheumatol Rep. 2017 Aug;19(8):45. doi: 10.1007/s11926-017-0672-6. Review. PubMed PMID: 28718060.
Barboza E, Hudson J, Chang WP, Kovats S, Towner RA, Silasi-Mansat R, Lupu F, Kent C, Griffin TM. Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity. Arthritis Rheumatol. 2017 Jun;69(6):1221-1232. doi: 10.1002/art.40056. Epub 2017 Apr 28. PubMed PMID: 28141918; PubMed Central PMCID: PMC5449220.
Berenbaum F, Griffin TM, Liu-Bryan R. Review: Metabolic Regulation of Inflammation in Osteoarthritis. Arthritis Rheumatol. 2017 Jan;69(1):9-21. doi: 10.1002/art.39842. Review. PubMed PMID: 27564539; PubMed Central PMCID: PMC5341385.
June RK, Liu-Bryan R, Long F, Griffin TM. Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis. J Orthop Res. 2016 Dec;34(12):2048-2058. doi: 10.1002/jor.23420. Epub 2016 Sep 26. Review. PubMed PMID: 27605370; PubMed Central PMCID: PMC5365077.
Fu Y, Huebner JL, Kraus VB, Griffin TM. Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1131-40. doi: 10.1093/gerona/glv151. Epub 2015 Oct 8. PubMed PMID: 26450946; PubMed Central PMCID: PMC4978355.
Fu Y, Kinter M, Hudson J, Humphries KM, Lane RS, White JR, Hakim M, Pan Y, Verdin E, Griffin TM. Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis. Arthritis Rheumatol. 2016 Aug;68(8):1887-98. doi: 10.1002/art.39618. PubMed PMID: 26866626; PubMed Central PMCID: PMC5331855.
Griffin TM, Huffman KM. Editorial: Insulin Resistance: Releasing the Brakes on Synovial Inflammation and Osteoarthritis?. Arthritis Rheumatol. 2016 Jun;68(6):1330-3. doi: 10.1002/art.39586. PubMed PMID: 26749517; PubMed Central PMCID: PMC5371020.
Griffin TM, Humphries KM, Kinter M, Lim HY, Szweda LI. Nutrient sensing and utilization: Getting to the heart of metabolic flexibility. Biochimie. 2016 May;124:74-83. doi: 10.1016/j.biochi.2015.10.013. Epub 2015 Oct 22. Review. PubMed PMID: 26476002; PubMed Central PMCID: PMC4828282.
Wiley MM, Muthukumar V, Griffin TM, Griffin CT. SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice. J Am Heart Assoc. 2015 Apr 22;4(4). doi: 10.1161/JAHA.115.001972. PubMed PMID: 25904594; PubMed Central PMCID: PMC4579958.
Lane RS, Fu Y, Matsuzaki S, Kinter M, Humphries KM, Griffin TM. Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Res Ther. 2015 Mar 10;17:54. doi: 10.1186/s13075-015-0566-9. PubMed PMID: 25889867; PubMed Central PMCID: PMC4384316.
Fu Y, Griffin TM. Obesity, Osteoarthritis, and Aging: The Biomechanical Links . In: The Mechanobiology of Obesity and Related Diseases. Gefen A, Benayahu D, editors. Berlin Heidelberg: Springer; 2015. p.181-201.
Zhao Y, Ling F, Griffin TM, He T, Towner R, Ruan H, Sun XH. Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance. J Biol Chem. 2014 Oct 17;289(42):29112-22. doi: 10.1074/jbc.M114.571679. Epub 2014 Sep 4. PubMed PMID: 25190816; PubMed Central PMCID: PMC4200265.
Yao L, Heuser-Baker J, Herlea-Pana O, Zhang N, Szweda LI, Griffin TM, Barlic-Dicen J. Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. FASEB J. 2014 Oct;28(10):4534-50. doi: 10.1096/fj.14-249797. Epub 2014 Jul 11. PubMed PMID: 25016030; PubMed Central PMCID: PMC4202106.
Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM. Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice. Osteoarthritis Cartilage. 2014 Sep;22(9):1301-9. doi: 10.1016/j.joca.2014.06.033. Epub 2014 Jul 4. PubMed PMID: 25008209; PubMed Central PMCID: PMC4150746.
Garteiser P, Doblas S, Towner RA, Griffin TM. Calibration of a semi-automated segmenting method for quantification of adipose tissue compartments from magnetic resonance images of mice. Metabolism. 2013 Nov;62(11):1686-95. doi: 10.1016/j.metabol.2013.06.009. Epub 2013 Jul 25. PubMed PMID: 23890668; PubMed Central PMCID: PMC3809152.
O'Conor CJ, Griffin TM, Liedtke W, Guilak F. Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Ann Rheum Dis. 2013 Feb;72(2):300-4. doi: 10.1136/annrheumdis-2012-202272. Epub 2012 Nov 23. PubMed PMID: 23178209; PubMed Central PMCID: PMC3549299.
Roach GC, Edke M, Griffin TM. A novel mouse running wheel that senses individual limb forces: biomechanical validation and in vivo testing. J Appl Physiol (1985). 2012 Aug 15;113(4):627-35. doi: 10.1152/japplphysiol.00272.2012. Epub 2012 Jun 21. PubMed PMID: 22723628; PubMed Central PMCID: PMC4422345.
Issa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol Aging Age Relat Dis. 2012 May 9;2(2012). doi: 10.3402/pba.v2i0.17470. PubMed PMID: 22662293; PubMed Central PMCID: PMC3364606.
Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F. Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. Arthritis Rheum. 2012 Feb;64(2):443-53. doi: 10.1002/art.33332. PubMed PMID: 21953366; PubMed Central PMCID: PMC3268860.
Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Cao L, Setton LA, Guilak F. Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther. 2010;12(4):R130. doi: 10.1186/ar3068. Epub 2010 Jul 6. PubMed PMID: 20604941; PubMed Central PMCID: PMC2945020.
Costello KE, Guilak F, Setton LA, Griffin TM. Locomotor activity and gait in aged mice deficient for type IX collagen. J Appl Physiol (1985). 2010 Jul;109(1):211-8. doi: 10.1152/japplphysiol.00056.2010. Epub 2010 Apr 1. PubMed PMID: 20360435; PubMed Central PMCID: PMC2904201.
Griffin TM, Huebner JL, Kraus VB, Guilak F. Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum. 2009 Oct;60(10):2935-44. doi: 10.1002/art.24854. PubMed PMID: 19790050; PubMed Central PMCID: PMC2829313.
Allen KD, Griffin TM, Rodriguiz RM, Wetsel WC, Kraus VB, Huebner JL, Boyd LM, Setton LA. Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. Arthritis Rheum. 2009 Sep;60(9):2684-93. doi: 10.1002/art.24783. PubMed PMID: 19714629; PubMed Central PMCID: PMC2760314.
Hanna JB, Schmitt D, Griffin TM. The energetic cost of climbing in primates. Science. 2008 May 16;320(5878):898. doi: 10.1126/science.1155504. PubMed PMID: 18487185.
Griffin TM, Guilak F. Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology. 2008;45(3-4):387-98. PubMed PMID: 18836239; PubMed Central PMCID: PMC2748656.
Griffin TM. Powering locomotion? It's a loaded question. J Appl Physiol (1985). 2006 Nov;101(5):1273-4. doi: 10.1152/japplphysiol.00788.2006. Epub 2006 Jul 27. PubMed PMID: 16873600.
Schmitt D, Cartmill M, Griffin TM, Hanna JB, Lemelin P. Adaptive value of ambling gaits in primates and other mammals. J Exp Biol. 2006 Jun;209(Pt 11):2042-9. doi: 10.1242/jeb.02235. PubMed PMID: 16709907.
Griffin TM, Guilak F. The role of mechanical loading in the onset and progression of osteoarthritis. Exerc Sport Sci Rev. 2005 Oct;33(4):195-200. doi: 10.1097/00003677-200510000-00008. Review. PubMed PMID: 16239837.
Griffin TM, Kram R, Wickler SJ, Hoyt DF. Biomechanical and energetic determinants of the walk-trot transition in horses. J Exp Biol. 2004 Nov;207(Pt 24):4215-23. doi: 10.1242/jeb.01277. PubMed PMID: 15531642.
Griffin TM, Main RP, Farley CT. Biomechanics of quadrupedal walking: how do four-legged animals achieve inverted pendulum-like movements?. J Exp Biol. 2004 Sep;207(Pt 20):3545-58. doi: 10.1242/jeb.01177. PubMed PMID: 15339951.
Griffin TM, Roberts TJ, Kram R. Metabolic cost of generating muscular force in human walking: insights from load-carrying and speed experiments. J Appl Physiol (1985). 2003 Jul;95(1):172-83. doi: 10.1152/japplphysiol.00944.2002. PubMed PMID: 12794096.
Griffin TM, Kram R. Penguin waddling is not wasteful. Nature. 2000 Dec 21-28;408(6815):929. doi: 10.1038/35050167. PubMed PMID: 11140670.
Griffin TM, Tolani NA, Kram R. Walking in simulated reduced gravity: mechanical energy fluctuations and exchange. J Appl Physiol (1985). 1999 Jan;86(1):383-90. doi: 10.1152/jappl.1999.86.1.383. PubMed PMID: 9887153.
Kram R, Griffin TM, Donelan JM, Chang YH. Force treadmill for measuring vertical and horizontal ground reaction forces. J Appl Physiol (1985). 1998 Aug;85(2):764-9. doi: 10.1152/jappl.1998.85.2.764. PubMed PMID: 9688758.
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