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Iovine JC, Claypool SM, Alder NN. Mitochondrial compartmentalization: emerging themes in structure and function. Trends Biochem Sci. 2021 Nov;46(11):902-917. doi: 10.1016/j.tibs.2021.06.003. Epub 2021 Jul 7. Review. PubMed PMID: 34244035.
Anzmann AF, Sniezek OL, Pado A, Busa V, Vaz FM, Kreimer SD, DeVine LR, Cole RN, Le A, Kirsch BJ, Claypool SM, Vernon HJ. Diverse mitochondrial abnormalities in a new cellular model of TAFFAZZIN deficiency are remediated by cardiolipin-interacting small molecules. J Biol Chem. 2021 Sep;297(3):101005. doi: 10.1016/j.jbc.2021.101005. Epub 2021 Jul 24. PubMed PMID: 34314685; PubMed Central PMCID: PMC8384898.
Elkes M, Andonovski M, Vidal D, Farago M, Modafferi R, Claypool SM, LeBlanc PJ. The Influence of Supplemental Dietary Linoleic Acid on Skeletal Muscle Contractile Function in a Rodent Model of Barth Syndrome. Front Physiol. 2021;12:731961. doi: 10.3389/fphys.2021.731961. eCollection 2021. PubMed PMID: 34489741; PubMed Central PMCID: PMC8416984.
Maguire ARR, Crozier RWE, Hunter KD, Claypool SM, Fajardo VA, LeBlanc PJ, MacNeil AJ. Tafazzin Modulates Allergen-Induced Mast Cell Inflammatory Mediator Secretion. Immunohorizons. 2021 Apr 24;5(4):182-192. doi: 10.4049/immunohorizons.2000040. PubMed PMID: 33895725.
Falabella M, Vernon HJ, Hanna MG, Claypool SM, Pitceathly RDS. Cardiolipin, Mitochondria, and Neurological Disease. Trends Endocrinol Metab. 2021 Apr;32(4):224-237. doi: 10.1016/j.tem.2021.01.006. Epub 2021 Feb 24. Review. PubMed PMID: 33640250; PubMed Central PMCID: PMC8277580.
Sam PN, Calzada E, Acoba MG, Zhao T, Watanabe Y, Nejatfard A, Trinidad JC, Shutt TE, Neal SE, Claypool SM. Impaired phosphatidylethanolamine metabolism activates a reversible stress response that detects and resolves mutant mitochondrial precursors. iScience. 2021 Mar 19;24(3):102196. doi: 10.1016/j.isci.2021.102196. eCollection 2021 Mar 19. PubMed PMID: 33718843; PubMed Central PMCID: PMC7921845.
Acoba MG, Alpergin ESS, Renuse S, Fernández-Del-Río L, Lu YW, Khalimonchuk O, Clarke CF, Pandey A, Wolfgang MJ, Claypool SM. The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Rep. 2021 Mar 16;34(11):108869. doi: 10.1016/j.celrep.2021.108869. PubMed PMID: 33730581; PubMed Central PMCID: PMC8048093.
Kliment CR, Nguyen JMK, Kaltreider MJ, Lu Y, Claypool SM, Radder JE, Sciurba FC, Zhang Y, Gregory AD, Iglesias PA, Sidhaye VK, Robinson DN. Adenine nucleotide translocase regulates airway epithelial metabolism, surface hydration and ciliary function. J Cell Sci. 2021 Feb 25;134(4). doi: 10.1242/jcs.257162. PubMed PMID: 33526710; PubMed Central PMCID: PMC7929926.
Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ. Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria. J Biol Chem. 2020 Aug 28;295(35):12485-12497. doi: 10.1074/jbc.RA119.011229. Epub 2020 Jul 14. PubMed PMID: 32665401; PubMed Central PMCID: PMC7458807.
Senoo N, Kandasamy S, Ogunbona OB, Baile MG, Lu Y, Claypool SM. Cardiolipin, conformation, and respiratory complex-dependent oligomerization of the major mitochondrial ADP/ATP carrier in yeast. Sci Adv. 2020 Aug;6(35):eabb0780. doi: 10.1126/sciadv.abb0780. eCollection 2020 Aug. PubMed PMID: 32923632; PubMed Central PMCID: PMC7455186.
Acoba MG, Senoo N, Claypool SM. Phospholipid ebb and flow makes mitochondria go. J Cell Biol. 2020 Aug 3;219(8). doi: 10.1083/jcb.202003131. Review. PubMed PMID: 32614384; PubMed Central PMCID: PMC7401802.
Sniezek OL, Anzmann AF, Claypool SM, Vernon HJ. Cardiolipin's Remodeling Rules Revealed: The Role of the Cellular Lipidome. Cell Rep. 2020 Mar 24;30(12):3949-3950. doi: 10.1016/j.celrep.2020.03.010. PubMed PMID: 32209457.
Sam PN, Avery E, Claypool SM. Proteolytic Control of Lipid Metabolism. ACS Chem Biol. 2019 Nov 15;14(11):2406-2423. doi: 10.1021/acschembio.9b00695. Epub 2019 Sep 30. Review. PubMed PMID: 31503446; PubMed Central PMCID: PMC6989095.
Suresh K, Servinsky L, Jiang H, Bigham Z, Zaldumbide J, Huetsch JC, Kliment C, Acoba MG, Kirsch BJ, Claypool SM, Le A, Damarla M, Shimoda LA. Regulation of mitochondrial fragmentation in microvascular endothelial cells isolated from the SU5416/hypoxia model of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L639-L652. doi: 10.1152/ajplung.00396.2018. Epub 2019 Aug 28. PubMed PMID: 31461316; PubMed Central PMCID: PMC6879901.
Gokhale A, Hartwig C, Freeman AAH, Bassell JL, Zlatic SA, Sapp Savas C, Vadlamudi T, Abudulai F, Pham TT, Crocker A, Werner E, Wen Z, Repetto GM, Gogos JA, Claypool SM, Forsyth JK, Bearden CE, Glausier J, Lewis DA, Seyfried NT, Kwong JQ, Faundez V. Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior. J Neurosci. 2019 May 1;39(18):3561-3581. doi: 10.1523/JNEUROSCI.1983-18.2019. Epub 2019 Mar 4. PubMed PMID: 30833507; PubMed Central PMCID: PMC6495129.
Seneviratne AK, Xu M, Henao JJA, Fajardo VA, Hao Z, Voisin V, Xu GW, Hurren R, Kim S, MacLean N, Wang X, Gronda M, Jeyaraju D, Jitkova Y, Ketela T, Mullokandov M, Sharon D, Thomas G, Chouinard-Watkins R, Hawley JR, Schafer C, Yau HL, Khuchua Z, Aman A, Al-Awar R, Gross A, Claypool SM, Bazinet RP, Lupien M, Chan S, De Carvalho DD, Minden MD, Bader GD, Stark KD, LeBlanc P, Schimmer AD. The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids. Cell Stem Cell. 2019 Apr 4;24(4):621-636.e16. doi: 10.1016/j.stem.2019.02.020. Epub 2019 Mar 28. PubMed PMID: 30930145; PubMed Central PMCID: PMC7137093.
Zhao T, Goedhart CM, Sam PN, Sabouny R, Lingrell S, Cornish AJ, Lamont RE, Bernier FP, Sinasac D, Parboosingh JS, Vance JE, Claypool SM, Innes AM, Shutt TE. PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts, and white matter changes. Life Sci Alliance. 2019 Apr;2(2). doi: 10.26508/lsa.201900353. Print 2019 Apr. PubMed PMID: 30858161; PubMed Central PMCID: PMC6412922.
Calzada E, Avery E, Sam PN, Modak A, Wang C, McCaffery JM, Han X, Alder NN, Claypool SM. Phosphatidylethanolamine made in the inner mitochondrial membrane is essential for yeast cytochrome bc1 complex function. Nat Commun. 2019 Mar 29;10(1):1432. doi: 10.1038/s41467-019-09425-1. PubMed PMID: 30926815; PubMed Central PMCID: PMC6441012.
Ogunbona OB, Claypool SM. Emerging Roles in the Biogenesis of Cytochrome c Oxidase for Members of the Mitochondrial Carrier Family. Front Cell Dev Biol. 2019;7:3. doi: 10.3389/fcell.2019.00003. eCollection 2019. Review. PubMed PMID: 30766870; PubMed Central PMCID: PMC6365663.
Ogunbona OB, Baile MG, Claypool SM. Cardiomyopathy-associated mutation in the ADP/ATP carrier reveals translation-dependent regulation of cytochrome c oxidase activity. Mol Biol Cell. 2018 Jun 15;29(12):1449-1464. doi: 10.1091/mbc.E17-12-0700. Epub 2018 Apr 24. PubMed PMID: 29688796; PubMed Central PMCID: PMC6014099.
Wang S, Shi X, Wei S, Ma D, Oyinlade O, Lv SQ, Ying M, Zhang YA, Claypool SM, Watkins P, Xia S. Krüppel-like factor 4 (KLF4) induces mitochondrial fusion and increases spare respiratory capacity of human glioblastoma cells. J Biol Chem. 2018 Apr 27;293(17):6544-6555. doi: 10.1074/jbc.RA117.001323. Epub 2018 Mar 5. PubMed PMID: 29507094; PubMed Central PMCID: PMC5925822.
Ogunbona OB, Onguka O, Calzada E, Claypool SM. Multitiered and Cooperative Surveillance of Mitochondrial Phosphatidylserine Decarboxylase 1. Mol Cell Biol. 2017 Sep 1;37(17). doi: 10.1128/MCB.00049-17. Print 2017 Sep 1. PubMed PMID: 28606933; PubMed Central PMCID: PMC5559681.
Bowman CE, Rodriguez S, Selen Alpergin ES, Acoba MG, Zhao L, Hartung T, Claypool SM, Watkins PA, Wolfgang MJ. The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency. Cell Chem Biol. 2017 Jun 22;24(6):673-684.e4. doi: 10.1016/j.chembiol.2017.04.009. Epub 2017 May 4. PubMed PMID: 28479296; PubMed Central PMCID: PMC5482780.
Lu YW, Acoba MG, Selvaraju K, Huang TC, Nirujogi RS, Sathe G, Pandey A, Claypool SM. Human adenine nucleotide translocases physically and functionally interact with respirasomes. Mol Biol Cell. 2017 Jun 1;28(11):1489-1506. doi: 10.1091/mbc.E17-03-0195. Epub 2017 Apr 12. PubMed PMID: 28404750; PubMed Central PMCID: PMC5449148.
Steffen J, Vashisht AA, Wan J, Jen JC, Claypool SM, Wohlschlegel JA, Koehler CM. Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria. Mol Biol Cell. 2017 Mar 1;28(5):600-612. doi: 10.1091/mbc.E16-07-0545. Epub 2017 Jan 5. PubMed PMID: 28057766; PubMed Central PMCID: PMC5328619.
Seifert EL, Gál A, Acoba MG, Li Q, Anderson-Pullinger L, Golenár T, Moffat C, Sondheimer N, Claypool SM, Hajnóczky G. Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION. J Biol Chem. 2016 Dec 9;291(50):26126-26137. doi: 10.1074/jbc.M116.744714. Epub 2016 Oct 25. PubMed PMID: 27780865; PubMed Central PMCID: PMC5207081.
Cole LK, Mejia EM, Vandel M, Sparagna GC, Claypool SM, Dyck-Chan L, Klein J, Hatch GM. Impaired Cardiolipin Biosynthesis Prevents Hepatic Steatosis and Diet-Induced Obesity. Diabetes. 2016 Nov;65(11):3289-3300. doi: 10.2337/db16-0114. Epub 2016 Aug 5. PubMed PMID: 27495222; PubMed Central PMCID: PMC5079636.
Lu YW, Galbraith L, Herndon JD, Lu YL, Pras-Raves M, Vervaart M, Van Kampen A, Luyf A, Koehler CM, McCaffery JM, Gottlieb E, Vaz FM, Claypool SM. Defining functional classes of Barth syndrome mutation in humans. Hum Mol Genet. 2016 May 1;25(9):1754-70. doi: 10.1093/hmg/ddw046. Epub 2016 Feb 16. PubMed PMID: 26908608; PubMed Central PMCID: PMC4986330.
Calzada E, Onguka O, Claypool SM. Phosphatidylethanolamine Metabolism in Health and Disease. Int Rev Cell Mol Biol. 2016;321:29-88. doi: 10.1016/bs.ircmb.2015.10.001. Epub 2015 Oct 31. Review. PubMed PMID: 26811286; PubMed Central PMCID: PMC4778737.
Pokorná L, Čermáková P, Horváth A, Baile MG, Claypool SM, Griač P, Malínský J, Balážová M. Specific degradation of phosphatidylglycerol is necessary for proper mitochondrial morphology and function. Biochim Biophys Acta. 2016 Jan;1857(1):34-45. doi: 10.1016/j.bbabio.2015.10.004. Epub 2015 Oct 19. PubMed PMID: 26482708; PubMed Central PMCID: PMC4690203.
Bohovych I, Fernandez MR, Rahn JJ, Stackley KD, Bestman JE, Anandhan A, Franco R, Claypool SM, Lewis RE, Chan SS, Khalimonchuk O. Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability. Sci Rep. 2015 Sep 14;5:13989. doi: 10.1038/srep13989. PubMed PMID: 26365306; PubMed Central PMCID: PMC4568518.
Onguka O, Calzada E, Ogunbona OB, Claypool SM. Phosphatidylserine decarboxylase 1 autocatalysis and function does not require a mitochondrial-specific factor. J Biol Chem. 2015 May 15;290(20):12744-52. doi: 10.1074/jbc.M115.641118. Epub 2015 Mar 31. PubMed PMID: 25829489; PubMed Central PMCID: PMC4432291.
Xu Y, Malhotra A, Claypool SM, Ren M, Schlame M. Tafazzins from Drosophila and mammalian cells assemble in large protein complexes with a short half-life. Mitochondrion. 2015 Mar;21:27-32. doi: 10.1016/j.mito.2015.01.002. Epub 2015 Jan 15. PubMed PMID: 25598000; PubMed Central PMCID: PMC4693151.
Lu YW, Claypool SM. Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genes. Front Genet. 2015;6:3. doi: 10.3389/fgene.2015.00003. eCollection 2015. Review. PubMed PMID: 25691889; PubMed Central PMCID: PMC4315098.
Moffat C, Bhatia L, Nguyen T, Lynch P, Wang M, Wang D, Ilkayeva OR, Han X, Hirschey MD, Claypool SM, Seifert EL. Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver. J Lipid Res. 2014 Dec;55(12):2458-70. doi: 10.1194/jlr.M046961. Epub 2014 Aug 11. PubMed PMID: 25114170; PubMed Central PMCID: PMC4242439.
Baile MG, Lu YW, Claypool SM. The topology and regulation of cardiolipin biosynthesis and remodeling in yeast. Chem Phys Lipids. 2014 Apr;179:25-31. doi: 10.1016/j.chemphyslip.2013.10.008. Epub 2013 Nov 1. Review. PubMed PMID: 24184646; PubMed Central PMCID: PMC3947685.
Baile MG, Sathappa M, Lu YW, Pryce E, Whited K, McCaffery JM, Han X, Alder NN, Claypool SM. Unremodeled and remodeled cardiolipin are functionally indistinguishable in yeast. J Biol Chem. 2014 Jan 17;289(3):1768-78. doi: 10.1074/jbc.M113.525733. Epub 2013 Nov 27. PubMed PMID: 24285538; PubMed Central PMCID: PMC3894353.
Herndon JD, Claypool SM, Koehler CM. The Taz1p transacylase is imported and sorted into the outer mitochondrial membrane via a membrane anchor domain. Eukaryot Cell. 2013 Dec;12(12):1600-8. doi: 10.1128/EC.00237-13. Epub 2013 Sep 27. PubMed PMID: 24078306; PubMed Central PMCID: PMC3889572.
Thomas E, Roman E, Claypool S, Manzoor N, Pla J, Panwar SL. Mitochondria influence CDR1 efflux pump activity, Hog1-mediated oxidative stress pathway, iron homeostasis, and ergosterol levels in Candida albicans. Antimicrob Agents Chemother. 2013 Nov;57(11):5580-99. doi: 10.1128/AAC.00889-13. Epub 2013 Aug 26. PubMed PMID: 23979757; PubMed Central PMCID: PMC3811284.
Baile MG, Whited K, Claypool SM. Deacylation on the matrix side of the mitochondrial inner membrane regulates cardiolipin remodeling. Mol Biol Cell. 2013 Jun;24(12):2008-20. doi: 10.1091/mbc.E13-03-0121. Epub 2013 May 1. PubMed PMID: 23637464; PubMed Central PMCID: PMC3681703.
Whited K, Baile MG, Currier P, Claypool SM. Seven functional classes of Barth syndrome mutation. Hum Mol Genet. 2013 Feb 1;22(3):483-92. doi: 10.1093/hmg/dds447. Epub 2012 Oct 24. PubMed PMID: 23100323; PubMed Central PMCID: PMC3606006.
Baile MG, Claypool SM. The power of yeast to model diseases of the powerhouse of the cell. Front Biosci (Landmark Ed). 2013 Jan 1;18(1):241-78. doi: 10.2741/4098. Review. PubMed PMID: 23276920; PubMed Central PMCID: PMC3874933.
Tamura Y, Onguka O, Itoh K, Endo T, Iijima M, Claypool SM, Sesaki H. Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P. J Biol Chem. 2012 Dec 21;287(52):43961-71. doi: 10.1074/jbc.M112.390997. Epub 2012 Nov 2. PubMed PMID: 23124206; PubMed Central PMCID: PMC3527979.
Tamura Y, Onguka O, Hobbs AE, Jensen RE, Iijima M, Claypool SM, Sesaki H. Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking. J Biol Chem. 2012 May 4;287(19):15205-18. doi: 10.1074/jbc.M111.338665. Epub 2012 Mar 7. PubMed PMID: 22403410; PubMed Central PMCID: PMC3346110.
Claypool SM, Koehler CM. The complexity of cardiolipin in health and disease. Trends Biochem Sci. 2012 Jan;37(1):32-41. doi: 10.1016/j.tibs.2011.09.003. Epub 2011 Oct 17. Review. PubMed PMID: 22014644; PubMed Central PMCID: PMC3259273.
Claypool SM, Whited K, Srijumnong S, Han X, Koehler CM. Barth syndrome mutations that cause tafazzin complex lability. J Cell Biol. 2011 Feb 7;192(3):447-62. doi: 10.1083/jcb.201008177. PubMed PMID: 21300850; PubMed Central PMCID: PMC3101092.
Claypool SM. Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function. Biochim Biophys Acta. 2009 Oct;1788(10):2059-68. doi: 10.1016/j.bbamem.2009.04.020. Epub 2009 May 5. Review. PubMed PMID: 19422785; PubMed Central PMCID: PMC2757529.
Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG, Lencer WI, Blumberg RS. N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG. J Biol Chem. 2009 Mar 27;284(13):8292-300. doi: 10.1074/jbc.M805877200. Epub 2009 Jan 21. PubMed PMID: 19164298; PubMed Central PMCID: PMC2659187.
Claypool SM, Boontheung P, McCaffery JM, Loo JA, Koehler CM. The cardiolipin transacylase, tafazzin, associates with two distinct respiratory components providing insight into Barth syndrome. Mol Biol Cell. 2008 Dec;19(12):5143-55. doi: 10.1091/mbc.e08-09-0896. Epub 2008 Sep 17. PubMed PMID: 18799610; PubMed Central PMCID: PMC2592642.
Claypool SM, Oktay Y, Boontheung P, Loo JA, Koehler CM. Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane. J Cell Biol. 2008 Sep 8;182(5):937-50. doi: 10.1083/jcb.200801152. PubMed PMID: 18779372; PubMed Central PMCID: PMC2528576.
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