My Bibliography

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CRISPR genome surgery in a novel humanized model for autosomal dominant retinitis pigmentosa. Molecular therapy : the journal of the American Society of Gene Therapy. . NIHMSID: NIHMS1788823.doi: 10.1016/j.ymthe.2022.02.010.

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Tsang SH, Kan LS. 300 MHz proton NMR study of the differentiation of diploid human epidermal keratinocytes. Cell Biophys. 1990 Jun;16(3):127-38. doi: 10.1007/BF02991426. PubMed PMID: 1698549.

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Tsang SH, Gouras P, Yamashita CK, Kjeldbye H, Fisher J, Farber DB, Goff SP. Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase. Science. 1996 May 17;272(5264):1026-9. doi: 10.1126/science.272.5264.1026. PubMed PMID: 8638127; PubMed Central PMCID: PMC2757426.

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Tsang SH, Chen J, Kjeldbye H, Li WS, Simon MI, Gouras P, Goff SP. Retarding photoreceptor degeneration in Pdegtm1/Pdegtml mice by an apoptosis suppressor gene. Invest Ophthalmol Vis Sci. 1997 Apr;38(5):943-50. PubMed PMID: 9112990.

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Ortega S, Ittmann M, Tsang SH, Ehrlich M, Basilico C. Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5672-7. doi: 10.1073/pnas.95.10.5672. PubMed PMID: 9576942; PubMed Central PMCID: PMC20437.

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Tsang SH, Burns ME, Calvert PD, Gouras P, Baylor DA, Goff SP, Arshavsky VY. Role for the target enzyme in deactivation of photoreceptor G protein in vivo. Science. 1998 Oct 2;282(5386):117-21. doi: 10.1126/science.282.5386.117. PubMed PMID: 9756475.

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Lai CC, Gouras P, Doi K, Lu F, Kjeldbye H, Goff SP, Pawliuk R, Leboulch P, Tsang SH. Tracking RPE transplants labeled by retroviral gene transfer with green fluorescent protein. Invest Ophthalmol Vis Sci. 1999 Aug;40(9):2141-6. PubMed PMID: 10440271.

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Salchow DJ, Gouras P, Doi K, Goff SP, Schwinger E, Tsang SH. A point mutation (W70A) in the rod PDE-gamma gene desensitizing and delaying murine rod photoreceptors. Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3262-7. PubMed PMID: 10586951; PubMed Central PMCID: PMC2754065.

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Lai CC, Gouras P, Doi K, Tsang SH, Goff SP, Ashton P. Local immunosuppression prolongs survival of RPE xenografts labeled by retroviral gene transfer. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3134-41. PubMed PMID: 10967075.

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Tsang SH, Yamashita CK, Doi K, Salchow DJ, Bouvier N, Mendelsohn M, Gouras P, Farber DB, Goff SP. In vivo studies of the gamma subunit of retinal cGMP-phophodiesterase with a substitution of tyrosine-84. Biochem J. 2001 Feb 1;353(Pt 3):467-74. doi: 10.1042/0264-6021:3530467. PubMed PMID: 11171042; PubMed Central PMCID: PMC1221591.

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Doi K, Hargitai J, Kong J, Tsang SH, Wheatley M, Chang S, Goff S, Gouras P. Lentiviral transduction of green fluorescent protein in retinal epithelium: evidence of rejection. Vision Res. 2002 Feb;42(4):551-8. doi: 10.1016/s0042-6989(01)00237-1. PubMed PMID: 11853772.

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Tsang SH, Yamashita CK, Lee WH, Lin CS, Goff SP, Gouras P, Farber DB. The positive role of the carboxyl terminus of the gamma subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo. Vision Res. 2002 Feb;42(4):439-45. doi: 10.1016/s0042-6989(01)00213-9. PubMed PMID: 11853759.

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Gouras P, Kong J, Tsang SH. Retinal degeneration and RPE transplantation in Rpe65(-/-) mice. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3307-11. PubMed PMID: 12356839.

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Farber DB, Tsang SH. Stationary night blindness or progressive retinal degeneration in mice carrying different alleles of PDE gamma. Front Biosci. 2003 May 1;8:s666-75. doi: 10.2741/1111. Review. PubMed PMID: 12700134.

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Tsang SH, Woodruff ML, Chen CK, Yamashita CY, Cilluffo MC, Rao AL, Farber DB, Fain GL. GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase. J Neurosci. 2006 Apr 26;26(17):4472-80. doi: 10.1523/JNEUROSCI.4775-05.2006. PubMed PMID: 16641226; PubMed Central PMCID: PMC2852461.

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Tsang SH, Woodruff ML, Janisch KM, Cilluffo MC, Farber DB, Fain GL. Removal of phosphorylation sites of gamma subunit of phosphodiesterase 6 alters rod light response. J Physiol. 2007 Mar 1;579(Pt 2):303-12. doi: 10.1113/jphysiol.2006.121772. Epub 2006 Nov 30. PubMed PMID: 17138607; PubMed Central PMCID: PMC2075409.

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Lobanova ES, Finkelstein S, Song H, Tsang SH, Chen CK, Sokolov M, Skiba NP, Arshavsky VY. Transducin translocation in rods is triggered by saturation of the GTPase-activating complex. J Neurosci. 2007 Jan 31;27(5):1151-60. doi: 10.1523/JNEUROSCI.5010-06.2007. PubMed PMID: 17267570; PubMed Central PMCID: PMC6673185.

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Tsang SH, Vaclavik V, Bird AC, Robson AG, Holder GE. Novel phenotypic and genotypic findings in X-linked retinoschisis. Arch Ophthalmol. 2007 Feb;125(2):259-67. doi: 10.1001/archopht.125.2.259. PubMed PMID: 17296904; PubMed Central PMCID: PMC2757628.

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Tsang SH, Woodruff ML, Jun L, Mahajan V, Yamashita CK, Pedersen R, Lin CS, Goff SP, Rosenberg T, Larsen M, Farber DB, Nusinowitz S. Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness. Hum Mutat. 2007 Mar;28(3):243-54. doi: 10.1002/humu.20425. PubMed PMID: 17044014; PubMed Central PMCID: PMC2753261.

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Audo I, Tsang SH, Fu AD, Barnes JA, Holder GE, Moore AT. Autofluorescence imaging in a case of benign familial fleck retina. Arch Ophthalmol. 2007 May;125(5):714-5. doi: 10.1001/archopht.125.5.714. PubMed PMID: 17502520.

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Tsui I, Casper D, Chou CL, Tsang SH. Electronegative electroretinogram associated with topiramate toxicity and vitelliform maculopathy. Doc Ophthalmol. 2008 Jan;116(1):57-60. doi: 10.1007/s10633-007-9084-7. Epub 2007 Oct 3. PubMed PMID: 17912565; PubMed Central PMCID: PMC2750026.

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Tsui I, Fuchs BS, Chou CL, Chang S, Tsang SH. Non-vascular vision loss in pseudoxanthoma elasticum. Doc Ophthalmol. 2008 Jul;117(1):65-7. doi: 10.1007/s10633-007-9100-y. Epub 2007 Nov 22. PubMed PMID: 18034271; PubMed Central PMCID: PMC2754060.

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Woodruff ML, Janisch KM, Peshenko IV, Dizhoor AM, Tsang SH, Fain GL. Modulation of phosphodiesterase6 turnoff during background illumination in mouse rod photoreceptors. J Neurosci. 2008 Feb 27;28(9):2064-74. doi: 10.1523/JNEUROSCI.2973-07.2008. PubMed PMID: 18305241; PubMed Central PMCID: PMC2750778.

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Gong J, Sagiv O, Cai H, Tsang SH, Del Priore LV. Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors. Exp Eye Res. 2008 Jun;86(6):957-65. doi: 10.1016/j.exer.2008.03.014. Epub 2008 Mar 28. PubMed PMID: 18472095; PubMed Central PMCID: PMC4405535.

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Davis RJ, Tosi J, Janisch KM, Kasanuki JM, Wang NK, Kong J, Tsui I, Cilluffo M, Woodruff ML, Fain GL, Lin CS, Tsang SH. Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q). Invest Ophthalmol Vis Sci. 2008 Nov;49(11):5067-76. doi: 10.1167/iovs.07-1422. Epub 2008 Jul 24. PubMed PMID: 18658088; PubMed Central PMCID: PMC2715364.

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Tsang SH, Tsui I, Chou CL, Zernant J, Haamer E, Iranmanesh R, Tosi J, Allikmets R. A novel mutation and phenotypes in phosphodiesterase 6 deficiency. Am J Ophthalmol. 2008 Nov;146(5):780-8. doi: 10.1016/j.ajo.2008.06.017. Epub 2008 Aug 23. PubMed PMID: 18723146; PubMed Central PMCID: PMC2593460.

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Greenstein VC, Santos RA, Tsang SH, Smith RT, Barile GR, Seiple W. Preferred retinal locus in macular disease: characteristics and clinical implications. Retina. 2008 Oct;28(9):1234-40. doi: 10.1097/IAE.0b013e31817c1b47. PubMed PMID: 18628727; PubMed Central PMCID: PMC2749558.

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Tsui I, Chou CL, Palmer N, Lin CS, Tsang SH. Phenotype-genotype correlations in autosomal dominant retinitis pigmentosa caused by RHO, D190N. Curr Eye Res. 2008 Nov;33(11):1014-22. doi: 10.1080/02713680802484645. PubMed PMID: 19085385; PubMed Central PMCID: PMC2749948.

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Airiani S, Cella W, Chou CL, Tosi J, Tsang SH. Benign panretinal uniform radial linear-shaped flecks. Clin Exp Ophthalmol. 2008 Dec;36(9):891-4. doi: 10.1111/j.1442-9071.2009.01906.x. PubMed PMID: 19278486; PubMed Central PMCID: PMC2754066.

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Cella W, Greenstein VC, Zernant-Rajang J, Smith TR, Barile G, Allikmets R, Tsang SH. G1961E mutant allele in the Stargardt disease gene ABCA4 causes bull's eye maculopathy. Exp Eye Res. 2009 Jun 15;89(1):16-24. doi: 10.1016/j.exer.2009.02.001. Epub 2009 Feb 13. PubMed PMID: 19217903; PubMed Central PMCID: PMC2742677.

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Gomes NL, Greenstein VC, Carlson JN, Tsang SH, Smith RT, Carr RE, Hood DC, Chang S. A comparison of fundus autofluorescence and retinal structure in patients with Stargardt disease. Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3953-9. doi: 10.1167/iovs.08-2657. Epub 2009 Mar 25. PubMed PMID: 19324865; PubMed Central PMCID: PMC2749553.

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Wang NK, Chou CL, Lima LH, Cella W, Tosi J, Yannuzzi LA, Tsang SH. Fundus autofluorescence in cone dystrophy. Doc Ophthalmol. 2009 Oct;119(2):141-4. doi: 10.1007/s10633-009-9172-y. Epub 2009 Apr 2. PubMed PMID: 19340470; PubMed Central PMCID: PMC2752495.

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Tosi J, Janisch KM, Wang NK, Kasanuki JM, Flynn JT, Lin CS, Tsang SH. Cellular and molecular origin of circumpapillary dysgenesis of the pigment epithelium. Ophthalmology. 2009 May;116(5):971-80. doi: 10.1016/j.ophtha.2008.10.032. PubMed PMID: 19410955; PubMed Central PMCID: PMC2717946.

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Tosi J, Tsui I, Lima LH, Wang NK, Tsang SH. Case report: autofluorescence imaging and phenotypic variance in a sibling pair with early-onset retinal dystrophy due to defective CRB1 function. Curr Eye Res. 2009 May;34(5):395-400. doi: 10.1080/02713680902859639. PubMed PMID: 19401883; PubMed Central PMCID: PMC2717950.

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Wang NK, Fine HF, Chang S, Chou CL, Cella W, Tosi J, Lin CS, Nagasaki T, Tsang SH. Cellular origin of fundus autofluorescence in patients and mice with a defective NR2E3 gene. Br J Ophthalmol. 2009 Sep;93(9):1234-40. doi: 10.1136/bjo.2008.153577. Epub 2009 May 7. PubMed PMID: 19429590; PubMed Central PMCID: PMC2742679.

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Lima LH, Cella W, Greenstein VC, Wang NK, Busuioc M, Smith RT, Yannuzzi LA, Tsang SH. Structural assessment of hyperautofluorescent ring in patients with retinitis pigmentosa. Retina. 2009 Jul-Aug;29(7):1025-31. doi: 10.1097/IAE.0b013e3181ac2418. PubMed PMID: 19584660; PubMed Central PMCID: PMC2749567.

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Janisch KM, Kasanuki JM, Naumann MC, Davis RJ, Lin CS, Semple-Rowland S, Tsang SH. Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1149-53. doi: 10.1016/j.bbrc.2009.10.106. Epub 2009 Oct 28. PubMed PMID: 19878658; PubMed Central PMCID: PMC2787723.

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Goldberg N, Chou J, Moore A, Tsang S. Autofluorescence imaging in rubella retinopathy. Ocul Immunol Inflamm. 2009 Nov-Dec;17(6):400-2. doi: 10.3109/09273940903118634. PubMed PMID: 20001260; PubMed Central PMCID: PMC2814186.

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Tosi J, Wang NK, Zhao J, Chou CL, Kasanuki JM, Tsang SH, Nagasaki T. Rapid and noninvasive imaging of retinal ganglion cells in live mouse models of glaucoma. Mol Imaging Biol. 2010 Aug;12(4):386-93. doi: 10.1007/s11307-009-0292-2. Epub 2009 Nov 24. PubMed PMID: 19937134; PubMed Central PMCID: PMC2889038.

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Shah SS, Tsang SH, Mahajan VB. Erythropoetin receptor expression in the human diabetic retina. BMC Res Notes. 2009 Nov 25;2:234. doi: 10.1186/1756-0500-2-234. PubMed PMID: 19930719; PubMed Central PMCID: PMC2785834.

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Cella W, Lima LH, Wang NK, Tosi J, Yannuzzi LA, Tsang SH. Autofluorescence and High-Resolution OCT Findings Revealed Ciliopathy in Senior-Loken Syndrome. Ophthalmic Surg Lasers Imaging. 2010 Mar 9;:1-4. doi: 10.3928/15428877-20100215-55. [Epub ahead of print] PubMed PMID: 20337316; PubMed Central PMCID: PMC2943561.

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Ferrara DC, Costa RA, Tsang S, Calucci D, Jorge R, Freund KB. Multimodal fundus imaging in Best vitelliform macular dystrophy. Graefes Arch Clin Exp Ophthalmol. 2010 Oct;248(10):1377-86. doi: 10.1007/s00417-010-1381-2. Epub 2010 Apr 23. PubMed PMID: 20414784; PubMed Central PMCID: PMC2926169.

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Wang NK, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Transplantation. 2010 Apr 27;89(8):911-9. doi: 10.1097/TP.0b013e3181d45a61. PubMed PMID: 20164818; PubMed Central PMCID: PMC2855750.

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Hwang JC, Kim DY, Chou CL, Tsang SH. Fundus autofluorescence, optical coherence tomography, and electroretinogram findings in choroidal sclerosis. Retina. 2010 Jul-Aug;30(7):1095-103. doi: 10.1097/IAE.0b013e3181cd48f9. PubMed PMID: 20224472; PubMed Central PMCID: PMC2891359.

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Braunstein A, Trief D, Wang NK, Chang S, Tsang SH. Vitamin A deficiency in New York City. Lancet. 2010 Jul 24;376(9737):267. doi: 10.1016/S0140-6736(09)61874-2. PubMed PMID: 20663549; PubMed Central PMCID: PMC2929009.

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Burke TR, Allikmets R, Smith RT, Gouras P, Tsang SH. Loss of peripapillary sparing in non-group I Stargardt disease. Exp Eye Res. 2010 Nov;91(5):592-600. doi: 10.1016/j.exer.2010.07.018. Epub 2010 Aug 7. PubMed PMID: 20696155; PubMed Central PMCID: PMC2962723.

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Kim DY, Hwang JC, Moore AT, Bird AC, Tsang SH. Fundus autofluorescence and optical coherence tomography of congenital grouped albinotic spots. Retina. 2010 Sep;30(8):1217-22. doi: 10.1097/IAE.0b013e3181cea5a5. PubMed PMID: 20539258; PubMed Central PMCID: PMC2939199.

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Wang NK, Chou CL, Tsang SH. Comparing different imaging modalities in harada disease: a case report. Retin Cases Brief Rep. 2010 Fall;4(4):352-5. doi: 10.1097/ICB.0b013e3181b5ee42. PubMed PMID: 25390915; PubMed Central PMCID: PMC4388045.

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Nan-Kai W, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for Retinitis Pigmentosa: Transplantation 2010 April 27;89 (8): 911-919. Ann Neurosci. 2010 Oct;17(4):185-6. doi: 10.5214/ans.0972.7531.1017408. PubMed PMID: 25205903; PubMed Central PMCID: PMC4117017.

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Lima LH, Cella W, Brue C, Tsang SH. Unilateral electronegative ERG in a presumed central retinal artery occlusion. Clin Ophthalmol. 2010 Nov 17;4:1311-4. doi: 10.2147/OPTH.S10374. PubMed PMID: 21139671; PubMed Central PMCID: PMC2993105.