My Bibliography

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Foster M, Casey K, Cassel J, Ye Y, Diaz J, Shuda McGuire K, Barnoud T, Murphy ME. A Personalized Therapeutic Approach for Liver Cancers Expressing the African-Centric P47S Variant of TP53. Mol Cancer Res. 2026 Jul 2;24(7):618-629. doi: 10.1158/1541-7786.MCR-25-1297. PubMed PMID: 41854379; PubMed Central PMCID: PMC13147292.

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Seal S, Fanning LR, Bagley E, Bookhout C, Barry EL, O'Quinn EC, Snover DC, Lewin DN, Guglietta S, Kourtidis A, Shrubsole MJ, Baron JA, Mackenzie TA, Alekseyenko AV, Wallace K. Differences in T-cell Densities and Neighborhood Patterns in Human Colorectal Adenomas and Sessile Serrated Lesions. Cancer Epidemiol Biomarkers Prev. 2026 Jul 1;35(7):1174-1181. doi: 10.1158/1055-9965.EPI-26-0083. PubMed PMID: 42112839; PubMed Central PMCID: PMC13397129.

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Stubler R, Packirisamy C, Cagle JG, McKee P, Pettijohn A, Kolobova E, Dooley SA, Edens R, Giordano L, Muise-Helmericks R, Engevik KA, Engevik MA, Engevik AC. MYO5B deficiency is associated with altered MUC13 localization and DMBT1 accumulation in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2026 Aug 1;331(2):G183-G192. doi: 10.1152/ajpgi.00131.2026. Epub 2026 Jul 1. PubMed PMID: 42383456; NIHMSID:NIHMS2192594.

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Pournasr B, Duncan S. Modeling Inherited Methylmalonic Acidemia Using Isogenic Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mutations in Methylmalonyl-CoA Mutase. MicroPubl Biol. 2026;2026. doi: 10.17912/micropub.biology.002044. eCollection 2026. PubMed PMID: 42395894; PubMed Central PMCID: PMC13325032.

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Novotny LA, Martinez-Morant C, Duncan SA, Traktman P, Gooz M, Meissner EG. Mechanisms of Differential Signal Transduction by Interferon Lambda Receptor 1 Variants. J Innate Immun. 2026;18(1):315-333. doi: 10.1159/000552360. Epub 2026 May 29. PubMed PMID: 42213608; PubMed Central PMCID: PMC13399965.

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Kingsley C, Nair-Menon J, McKee PR, Daulagala AC, Yoon AJ, Pandruvada S, Engevik AC, Engevik MA, Kourtidis A. Apical Enrichment of the RNA Interference Machinery in Oral Stratified Epithelia Is Disrupted in Oral Cancer. Am J Pathol. 2026 Aug;196(8):1803-1818. doi: 10.1016/j.ajpath.2026.04.007. Epub 2026 May 4. PubMed PMID: 42092456.

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Blaszkiewicz J, Jiang YL, Liu JT, Martinez-Morant C, Dearth T, van Altena C, Lamprecht MP, Kappler C, Lee MH, Bethard JR, Ball LE, Duncan SA. Triazine Thiols Decrease Apolipoprotein B Secretion From Hepatocytes Through Inhibition of Human Carboxylesterase 1. Cell Mol Gastroenterol Hepatol. 2026;20(8):101796. doi: 10.1016/j.jcmgh.2026.101796. Epub 2026 Apr 29. PubMed PMID: 42061645; PubMed Central PMCID: PMC13260215.

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Burge RA, Bialousow L, Linke AJ, Coalson HS, Adair SJ, Sundararaj K, Smith M, Bumbleburg C, Bauer TW, Kashatus DF, Hobbs GA. PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer. Cancer Res. 2026 Apr 15;86(8):1854-1867. doi: 10.1158/0008-5472.CAN-24-4501. PubMed PMID: 41134579; PubMed Central PMCID: PMC12614194.

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Kamgar M, Hobbes GA, Davidson R, Dorbin D, Herrera J, Langenheim JF, Burge RA, Aldakkak M, Conrardy RD, Szabo A, Thalji SZ, Mayer B, Grahl JJ, Chung BY, Phan A, Thomas JP, Seo YD, Evans DB, Christians KK, Erickson B, Hall WA, George B, Tsai S, Lytle NK, Der CJ, Kurzrock R, McFall T. Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma. Cancer Res. 2026 Apr 15;86(8):2042-2059. doi: 10.1158/0008-5472.CAN-25-0018. PubMed PMID: 41134578; PubMed Central PMCID: PMC13080315.

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Burge RA, Le Roux O, Popow O, Spadafora VK, Rajesh C, Adair SJ, Bialousow L, Murphy C, Saberi S, Vaena SG, Taquey MC, Allen S, Han L, Helke KL, Sharma S, Ostrowski MC, Guttridge DC, Dincman TA, Bauer TW, Kashatus DF, McFall T, Haigis KM, Hollingsworth MA, Counter CM, Der CJ, Hobbs GA. KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment. Cancer Res. 2026 Apr 15;86(8):1868-1882. doi: 10.1158/0008-5472.CAN-25-2630. PubMed PMID: 41556816; PubMed Central PMCID: PMC13080325.

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Gutierrez A, Chetta KE, Puckett B, Haidacher SJ, Horvath TD, Engevik MA. Human milk and infant formula influence lactobacilli metabolism in a species-specific manner. NPJ Sci Food. 2026 Apr 2;10(1). doi: 10.1038/s41538-026-00759-x. PubMed PMID: 41927583; PubMed Central PMCID: PMC13216266.

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Martinez-Morant C, Liu JT, Jiang YL, Blaszkiewicz J, Duncan SA. Effect of triazine thiols on steady-state mRNA levels in iPSC-derived hepatocytes. MicroPubl Biol. 2026;2026. doi: 10.17912/micropub.biology.002062. eCollection 2026. PubMed PMID: 41867889; PubMed Central PMCID: PMC13005152.

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Savoca MT, Takemoto K, Hu J, Li L, Zhong Z, Lemasters JJ. Zonal hepatocellular responses to acute ethanol consumption: impacts on mitochondrial function and liver metabolism. Toxicol Sci. 2026 Mar 2;209(3). doi: 10.1093/toxsci/kfag013. PubMed PMID: 41668283; PubMed Central PMCID: PMC13016978.

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Sutton MM, Gregoski MJ, Rockey DC. Overuse of Intravenous Proton-Pump Inhibitors in the Treatment of Low-Risk Upper Gastrointestinal Bleeding. J Clin Gastroenterol. 2026 Mar 1;60(3):268-272. doi: 10.1097/MCG.0000000000002211. PubMed PMID: 40549584; NIHMSID:NIHMS2086084.

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Burge RA, Bialousow L, McFall T, Bamonte L, Johnson G, Smith M, Vaena SG, Comte-Walters S, Ball LE, Berto S, O'Bryan JP, Hobbs GA. Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction. Cancer Res Commun. 2025 Oct 1;5(10):1865-1878. doi: 10.1158/2767-9764.CRC-25-0281. PubMed PMID: 40951926; PubMed Central PMCID: PMC12541299.

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Risner A, Nair-Menon J, Cheedipudi A, Delaney JR, Gangaraju V, Kourtidis A. PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes. Biol Open. 2025 Sep 15;14(9). doi: 10.1242/bio.061942. Epub 2025 Sep 4. PubMed PMID: 40789164; PubMed Central PMCID: PMC12444863.

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Gudi RR, Taylor H, Johnson BM, Maurya R, Mulligan ME, Carter L, Westwater C, Vasu C. Human Gut Commensal Bacteroides fragilis Suppresses Mucin Production and Alters Microbiota Composition Resulting in Accelerated Type 1 Diabetes in Mice. Immunology. 2026 Jan;177(1):119-136. doi: 10.1111/imm.70032. Epub 2025 Aug 26. PubMed PMID: 40857071; PubMed Central PMCID: PMC12665808.

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Nair-Menon J, Kingsley C, Mesnaoui H, Risner A, Jarvis JE, Lin P, Wilson K, Rohrer B, Kourtidis A. The subcellular topology of the RNAi machinery is multifaceted and reveals adherens junctions as an epithelial hub. Sci Rep. 2025 Jul 10;15(1):24814. doi: 10.1038/s41598-025-09795-1. PubMed PMID: 40640449; PubMed Central PMCID: PMC12246189.

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Dooley SA, Stubler R, Maity PP, Múnera J, Kourtidis A, Engevik MA, Engevik AC. The Molecular Motor Myosin 5B and Its Folding Chaperone UNC45A Are Decreased in Colorectal Cancer. Cell Mol Gastroenterol Hepatol. 2025;19(9):101537. doi: 10.1016/j.jcmgh.2025.101537. Epub 2025 May 21. PubMed PMID: 40409685; PubMed Central PMCID: PMC12242456.

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Ibrahim A, Allam J, Rockey DC. Octreotide therapy in patients with a left ventricular assist device and bleeding gastrointestinal angiodysplasias. Am J Med Sci. 2025 Jul;370(1):41-46. doi: 10.1016/j.amjms.2025.03.008. Epub 2025 Mar 12. PubMed PMID: 40086695; PubMed Central PMCID: PMC12178815.

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Nair-Menon J, Kingsley C, Mesnaoui H, Lin P, Wilson K, Rohrer B, Kourtidis A. The subcellular topology of the RNAi machinery is multifaceted and reveals adherens junctions as an epithelial hub. Res Sq. 2025 Feb 21;. doi: 10.21203/rs.3.rs-5837046/v1. PubMed PMID: 40034449; PubMed Central PMCID: PMC11875308.

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Novotny LA, Kappler CS, Meissner EG. Function of Interferon Lambda Receptor 1 Variants in Stem Cell-Derived Hepatocytes with Abrogated Endogenous IFNLR1. J Interferon Cytokine Res. 2025 May;45(5):174-183. doi: 10.1089/jir.2024.0262. Epub 2025 Feb 10. PubMed PMID: 39929255.

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Yoon AJ, Carvajal RD, Graboyes EM, Kaczmar JM, Albergotti WG, Kejner AE, Troob SH, Philipone E, Anoma JS, Armeson KE, Hill EG, Richardson MS, Woods TR, Chera BS, Nourollah-Zadeh F, Lee BJ, Pandruvada S, Kourtidis A, Kingsley C, O'Quinn EC, Mills S, Jordan VC, Spencer M, Fails D, McKee TD, Zaidi M, Brisendine A, Horn S, Mehrotra S, Ogretmen B, Newman JG. Pilot clinical trial of neoadjuvant toll-like receptor 7 agonist (Imiquimod) immunotherapy in early-stage oral squamous cell carcinoma. Front Immunol. 2025;16:1530262. doi: 10.3389/fimmu.2025.1530262. eCollection 2025. PubMed PMID: 39931064; PubMed Central PMCID: PMC11807971.

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Liu CH, Zeng QM, Hu TY, Huang Y, Song Y, Guan H, Rockey DC, Tang H, Li S. Resmetirom and thyroid hormone receptor-targeted treatment for metabolic dysfunction-associated steatotic liver disease (MASLD). Portal Hypertens Cirrhosis. 2025 Mar;4(1):66-78. doi: 10.1002/poh2.100. Epub 2025 Jan 22. PubMed PMID: 40777891; PubMed Central PMCID: PMC12327538.

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Watson A, Harris RA, Engevik AC, Oezguen N, Nicholson MR, Dooley S, Stubler R, Satter LF, Karam LB, Kellermayer R. MYO5B and the Polygenic Landscape of Very Early-Onset Inflammatory Bowel Disease in an Ethnically Diverse Population. Inflamm Bowel Dis. 2025 Jan 6;31(1):189-199. doi: 10.1093/ibd/izae169. PubMed PMID: 39096520; PubMed Central PMCID: PMC12476980.

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Whaby M, Nair RS, O'Bryan JP. Probing RAS Function Using Monobody and NanoBiT Technologies. Methods Mol Biol. 2024;2797:211-225. doi: 10.1007/978-1-0716-3822-4_15. PubMed PMID: 38570462; PubMed Central PMCID: PMC11635904.

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Scribano FJ, Engevik KA, Gebert JT, Hyser JM. Live-Cell Fluorescence Imaging for Virus-Host Interactions. Methods Mol Biol. 2024;2751:33-46. doi: 10.1007/978-1-0716-3617-6_3. PubMed PMID: 38265708.

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Novotny LA, Meissner EG. Expression and function of interferon lambda receptor 1 variants. FEBS Lett. 2025 Feb;599(4):466-475. doi: 10.1002/1873-3468.15041. Epub 2024 Oct 22. Review. PubMed PMID: 39435588; PubMed Central PMCID: PMC11850208.

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Ticer TD, Tingler AM, Glover JS, Dooley SA, Kendrick J, Zackular JP, Devkota S, Wu GD, Mahalak K, Engevik A, Engevik MA. Bacterial metabolites influence the autofluorescence of Clostridioides difficile. Front Microbiol. 2024;15:1459795. doi: 10.3389/fmicb.2024.1459795. eCollection 2024. PubMed PMID: 39439940; PubMed Central PMCID: PMC11493716.

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Stubler R, Dooley SA, Edens R, Nicholson MR, Engevik AC. Intestinal Tuft Cells Are Enriched With Protocadherins. J Histochem Cytochem. 2024 Oct;72(10):611-622. doi: 10.1369/00221554241287267. Epub 2024 Oct 3. PubMed PMID: 39360911; PubMed Central PMCID: PMC11471013.

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Killingsworth ZK, Misare KR, Ryan AS, Ampolini EA, Mendenhall TT, Engevik MA, Hartman JH. Subcellular expression of CYP2E1 in HepG2 cells impacts response to free oleic and palmitic acid. Curr Res Toxicol. 2024;7:100195. doi: 10.1016/j.crtox.2024.100195. eCollection 2024. PubMed PMID: 39429948; PubMed Central PMCID: PMC11489078.

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Dooley SA, Kolobova E, Burman A, Kaji I, Digrazia JR, Stubler R, Goldstein A, Packirisamy C, Coutts AW, Saqui-Salces M, Gao N, Engevik MA, Shub MD, Goldenring JR, Engevik AC. Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells. Gastroenterology. 2025 Jan;168(1):84-98.e9. doi: 10.1053/j.gastro.2024.09.007. Epub 2024 Sep 18. PubMed PMID: 39299401; PubMed Central PMCID: PMC11663138.

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Allam J, De Melo S, Feagins LA, Agrawal D, Malespin M, Shuja A, Lara LF, Rockey DC. Comparison of 24 vs 72-hr octreotide infusion in acute esophageal variceal hemorrhage - A multi-center, randomized clinical trial. Am J Med Sci. 2025 Jan;369(1):71-76. doi: 10.1016/j.amjms.2024.08.027. Epub 2024 Sep 4. PubMed PMID: 39241828; PubMed Central PMCID: PMC11700778.

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Waller ME, Eichhorn CJ, Gutierrez A, Baatz JE, Wagner CL, Chetta KE, Engevik MA. Analyzing the Responses of Enteric Bacteria to Neonatal Intensive Care Supplements. Int J Microbiol. 2024;2024:3840327. doi: 10.1155/2024/3840327. eCollection 2024. PubMed PMID: 39220439; PubMed Central PMCID: PMC11364479.

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Hu J, Nieminen AL, Zhong Z, Lemasters JJ. Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity. Livers. 2024 Sep;4(3):333-351. doi: 10.3390/livers4030024. Epub 2024 Jul 30. PubMed PMID: 39554796; PubMed Central PMCID: PMC11567147.

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Savoca M, Takemoto K, Hu J, Li L, Jacob Kendrick B, Zhong Z, Lemasters JJ. MitoTracker Red for isolation of zone-specific hepatocytes and characterization of hepatic sublobular metabolism. Biochem Biophys Res Commun. 2024 Nov 26;735:150457. doi: 10.1016/j.bbrc.2024.150457. Epub 2024 Jul 26. PubMed PMID: 39146811; PubMed Central PMCID: PMC11532002.

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Dooley SA, Stubler R, Edens RM, McKee PR, Rucker JN, Engevik A. Optimized Protocol for Intestinal Swiss Rolls and Immunofluorescent Staining of Paraffin Embedded Tissue. J Vis Exp. 2024 Jul 19;(209). doi: 10.3791/66977. PubMed PMID: 39141543; PubMed Central PMCID: PMC12212290.

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Engevik KA, Hazzard A, Puckett B, Hoch KM, Haidacher SJ, Haag AM, Spinler JK, Versalovic J, Engevik MA, Horvath TD. Phylogenetically diverse bacterial species produce histamine. Syst Appl Microbiol. 2024 Sep;47(5):126539. doi: 10.1016/j.syapm.2024.126539. Epub 2024 Jul 17. PubMed PMID: 39029335.

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Doueiry C, Kappler CS, Martinez-Morant C, Duncan SA. A PNPLA3-Deficient iPSC-Derived Hepatocyte Screen Identifies Pathways to Potentially Reduce Steatosis in Metabolic Dysfunction-Associated Fatty Liver Disease. Int J Mol Sci. 2024 Jul 2;25(13). doi: 10.3390/ijms25137277. PubMed PMID: 39000384; PubMed Central PMCID: PMC11242544.

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Edens R, Gutierrez A, Engevik MA. Exploring the use of panaxynol from American ginseng to combat intestinal inflammation and colon cancer. Am J Physiol Gastrointest Liver Physiol. 2024 Aug 1;327(2):G120-G122. doi: 10.1152/ajpgi.00135.2024. Epub 2024 Jun 25. PubMed PMID: 38915278.

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Reeves KD, Figuereo YF, Weis VG, Hsu FC, Engevik MA, Krigsman A, Walker SJ. Mapping the geographical distribution of the mucosa-associated gut microbiome in GI-symptomatic children with autism spectrum disorder. Am J Physiol Gastrointest Liver Physiol. 2024 Aug 1;327(2):G217-G234. doi: 10.1152/ajpgi.00101.2024. Epub 2024 Jun 18. PubMed PMID: 38887795; PubMed Central PMCID: PMC11637567.

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Daulagala AC, Cetin M, Nair-Menon J, Jimenez DW, Bridges MC, Bradshaw AD, Sahin O, Kourtidis A. The epithelial adherens junction component PLEKHA7 regulates ECM remodeling and cell behavior through miRNA-mediated regulation of MMP1 and LOX. bioRxiv. 2024 May 30;. doi: 10.1101/2024.05.28.596237. PubMed PMID: 38853930; PubMed Central PMCID: PMC11160653.

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Ferretti GDS, Quaas CE, Bertolini I, Zuccotti A, Saatci O, Kashatus JA, Sharmin S, Lu DY, Poli ANR, Quesnelle AF, Rodriguez-Blanco J, de Cubas AA, Hobbs GA, Liu Q, O'Bryan JP, Salvino JM, Kashatus DF, Sahin O, Barnoud T. HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer. Cell Death Differ. 2024 Jul;31(7):881-896. doi: 10.1038/s41418-024-01310-9. Epub 2024 May 28. PubMed PMID: 38802657; PubMed Central PMCID: PMC11239841.

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Samuvel DJ, Lemasters JJ, Chou CJ, Zhong Z. LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a. Front Pharmacol. 2024;15:1386238. doi: 10.3389/fphar.2024.1386238. eCollection 2024. PubMed PMID: 38828459; PubMed Central PMCID: PMC11140137.

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Engevik KA, Scribano FJ, Gebert JT, Hyser JM. Purinergic Signaling Drives Multiple Aspects of Rotavirus Pathophysiology. bioRxiv. 2024 May 7;. doi: 10.1101/2024.05.07.592953. PubMed PMID: 38765995; PubMed Central PMCID: PMC11100750.

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Gebert JT, Scribano FJ, Engevik KA, Philip AA, Kawagishi T, Greenberg HB, Patton JT, Hyser JM. Viroporin activity from rotavirus nonstructural protein 4 induces intercellular calcium waves that contribute to pathogenesis. bioRxiv. 2024 May 7;. doi: 10.1101/2024.05.07.592929. PubMed PMID: 38765992; PubMed Central PMCID: PMC11100692.

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Sheridan M, Chowdhury N, Wellslager B, Oleinik N, Kassir MF, Lee HG, Engevik M, Peterson Y, Pandruvada S, Szulc ZM, Yilmaz Ö, Ogretmen B. Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors. iScience. 2024 Jun 21;27(6):109860. doi: 10.1016/j.isci.2024.109860. eCollection 2024 Jun 21. PubMed PMID: 38779482; PubMed Central PMCID: PMC11108982.

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Browning BD, Kirkland AE, Green R, Liu H, Glover JS, Ticer TD, Engevik MA, Alekseyenko AV, Ferguson PL, Tomko RL, Squeglia LM. Adolescent alcohol use is associated with differences in the diversity and composition of the oral microbiome. Alcohol Clin Exp Res (Hoboken). 2024 Jun;48(6):1025-1035. doi: 10.1111/acer.15331. Epub 2024 Apr 17. PubMed PMID: 38631877; PubMed Central PMCID: PMC11178446.

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Lillie IM, Booth CE, Horvath AE, Mondragon M, Engevik MA, Horvath TD. Characterizing arginine, ornithine, and putrescine pathways in enteric pathobionts. Microbiologyopen. 2024 Apr;13(2):e1408. doi: 10.1002/mbo3.1408. PubMed PMID: 38560776; PubMed Central PMCID: PMC10982811.

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Nascimento RR, Aquino CC, Sousa JK, Gadelha KL, Cajado AG, Schiebel CS, Dooley SA, Sousa PA, Rocha JA, Medeiros JR, Magalhães PC, Maria-Ferreira D, Gois MB, C P Lima-Junior R, V T Wong D, Lima AM, Engevik AC, Nicolau LD, Vale ML. SARS-CoV-2 Spike protein triggers gut impairment since mucosal barrier to innermost layers: From basic science to clinical relevance. Mucosal Immunol. 2024 Aug;17(4):565-583. doi: 10.1016/j.mucimm.2024.03.009. Epub 2024 Mar 29. PubMed PMID: 38555027.