Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Male contraception. Best practice & research. Clinical obstetrics & gynaecology. . NIHMSID: NIHMS745877.doi: 10.1016/j.bpobgyn.2014.05.008.
Page S, Miller JB, DiMario JX, Hager EJ, Moser A, Stockdale FE. Developmentally regulated expression of three slow isoforms of myosin heavy chain: diversity among the first fibers to form in avian muscle. Dev Biol. 1992 Nov;154(1):118-28. doi: 10.1016/0012-1606(92)90053-j. PubMed PMID: 1426621.
Page ST, Owen WC, Price K, Elwood PC. Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene. J Mol Biol. 1993 Feb 20;229(4):1175-83. doi: 10.1006/jmbi.1993.1116. PubMed PMID: 8445646.
Saikawa Y, Knight CB, Saikawa T, Page ST, Chabner BA, Elwood PC. Decreased expression of the human folate receptor mediates transport-defective methotrexate resistance in KB cells. J Biol Chem. 1993 Mar 5;268(7):5293-301. PubMed PMID: 7680349.
Page ST, van Oers NS, Perlmutter RM, Weiss A, Pullen AM. Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. Eur J Immunol. 1997 Feb;27(2):554-62. doi: 10.1002/eji.1830270229. PubMed PMID: 9045930.
Elwood PC, Nachmanoff K, Saikawa Y, Page ST, Pacheco P, Roberts S, Chung KN. The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure. Biochemistry. 1997 Feb 11;36(6):1467-78. doi: 10.1021/bi962070h. PubMed PMID: 9063895.
Hamerman JA, Page ST, Pullen AM. Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes. J Immunol. 1997 Aug 1;159(3):1240-6. PubMed PMID: 9233619.
Page ST, Bogatzki LY, Hamerman JA, Sweenie CH, Hogarth PJ, Malissen M, Perlmutter RM, Pullen AM. Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9459-64. doi: 10.1073/pnas.95.16.9459. PubMed PMID: 9689102; PubMed Central PMCID: PMC21360.
Page ST, Bogatzki LY, Hamerman JA, Malissen M, Perlmutter RM, Pullen AM. Differential effects of manipulating signaling in early T cell development in intestinal intraepithelial lymphocytes and thymocytes. Int Immunol. 1999 Feb;11(2):169-77. doi: 10.1093/intimm/11.2.169. PubMed PMID: 10069415.
Page ST, Amory JK, Bowman FD, Anawalt BD, Matsumoto AM, Bremner WJ, Tenover JL. Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab. 2005 Mar;90(3):1502-10. doi: 10.1210/jc.2004-1933. Epub 2004 Nov 30. PubMed PMID: 15572415; NIHMSID:NIHMS291946.
Herbst KL, Coviello AD, Page S, Amory JK, Anawalt BD, Bremner WJ. A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men. J Clin Endocrinol Metab. 2004 Dec;89(12):5959-65. doi: 10.1210/jc.2003-032123. PubMed PMID: 15579744.
Page ST, Herbst KL, Amory JK, Coviello AD, Anawalt BD, Matsumoto AM, Bremner WJ. Testosterone administration suppresses adiponectin levels in men. J Androl. 2005 Jan-Feb;26(1):85-92. PubMed PMID: 15611571; NIHMSID:NIHMS473227.
Anawalt BD, Amory JK, Herbst KL, Coviello AD, Page ST, Bremner WJ, Matsumoto AM. Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trial. J Androl. 2005 May-Jun;26(3):405-13. doi: 10.2164/jandrol.04135. PubMed PMID: 15867009.
Page ST, Plymate SR, Bremner WJ, Matsumoto AM, Hess DL, Lin DW, Amory JK, Nelson PS, Wu JD. Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites. Am J Physiol Endocrinol Metab. 2006 May;290(5):E856-63. doi: 10.1152/ajpendo.00484.2005. Epub 2005 Dec 13. PubMed PMID: 16352669; NIHMSID:NIHMS291929.
Amory JK, Page ST, Bremner WJ. Oral testosterone in oil: pharmacokinetic effects of 5alpha reduction by finasteride or dutasteride and food intake in men. J Androl. 2006 Jan-Feb;27(1):72-8. doi: 10.2164/jandrol.05058. PubMed PMID: 16400081.
Amory JK, Page ST, Bremner WJ. Drug insight: Recent advances in male hormonal contraception. Nat Clin Pract Endocrinol Metab. 2006 Jan;2(1):32-41. doi: 10.1038/ncpendmet0069. Review. PubMed PMID: 16932251.
Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab. 2006 Mar;91(3):843-50. doi: 10.1210/jc.2005-1326. Epub 2006 Jan 4. PubMed PMID: 16394089; NIHMSID:NIHMS291930.
Brockenbrough AT, Dittrich MO, Page ST, Smith T, Stivelman JC, Bremner WJ. Transdermal androgen therapy to augment EPO in the treatment of anemia of chronic renal disease. Am J Kidney Dis. 2006 Feb;47(2):251-62. doi: 10.1053/j.ajkd.2005.10.022. PubMed PMID: 16431254; NIHMSID:NIHMS291931.
Page ST, Lin DW, Mostaghel EA, Hess DL, True LD, Amory JK, Nelson PS, Matsumoto AM, Bremner WJ. Persistent intraprostatic androgen concentrations after medical castration in healthy men. J Clin Endocrinol Metab. 2006 Oct;91(10):3850-6. doi: 10.1210/jc.2006-0968. Epub 2006 Aug 1. PubMed PMID: 16882745; NIHMSID:NIHMS291932.
Page ST, Amory JK, Anawalt BD, Irwig MS, Brockenbrough AT, Matsumoto AM, Bremner WJ. Testosterone gel combined with depomedroxyprogesterone acetate is an effective male hormonal contraceptive regimen and is not enhanced by the addition of a GnRH antagonist. J Clin Endocrinol Metab. 2006 Nov;91(11):4374-80. doi: 10.1210/jc.2006-1411. Epub 2006 Aug 29. PubMed PMID: 16940442; NIHMSID:NIHMS291934.
Page ST, Kupelian V, Bremner WJ, McKinlay JB. The androgen receptor gene CAG repeat polymorphism does not predict increased risk of heart disease: longitudinal results from the Massachusetts Male Ageing Study. Clin Endocrinol (Oxf). 2006 Sep;65(3):333-9. doi: 10.1111/j.1365-2265.2006.02598.x. PubMed PMID: 16918952; NIHMSID:NIHMS291933.
Amory JK, Muller CH, Page ST, Leifke E, Pagel ER, Bhandari A, Subramanyam B, Bone W, Radlmaier A, Bremner WJ. Miglustat has no apparent effect on spermatogenesis in normal men. Hum Reprod. 2007 Mar;22(3):702-7. doi: 10.1093/humrep/del414. Epub 2006 Oct 25. PubMed PMID: 17067996; NIHMSID:NIHMS291935.
Kupelian V, Shabsigh R, Travison TG, Page ST, Araujo AB, McKinlay JB. Is there a relationship between sex hormones and erectile dysfunction? Results from the Massachusetts Male Aging Study. J Urol. 2006 Dec;176(6 Pt 1):2584-8. doi: 10.1016/j.juro.2006.08.020. PubMed PMID: 17085164; NIHMSID:NIHMS291936.
Aaltonen P, Amory JK, Anderson RA, Behre HM, Bialy G, Blithe D, Bone W, Bremner WJ, Colvard D, Cooper TG, Elliesen J, Gabelnick HL, Gu YQ, Handelsman DJ, Johansson EA, Kersemaekers W, Liu P, MacKay T, Matlin S, Mbizvo M, McLachlan RI, Meriggiola MC, Mletzko S, Mommers E, Muermans H, Nieschlag E, Odlind V, Page ST, Radlmaier A, Sitruk-Ware R, Swerdloff R, Wang C, Wu F, Zitzmann M. 10th Summit Meeting consensus: recommendations for regulatory approval for hormonal male contraception. J Androl. 2007 May-Jun;28(3):362-3. doi: 10.2164/jandrol.106.002311. Epub 2006 Dec 27. PubMed PMID: 17192594.
Amory JK, Page ST, Anawalt BD, Matsumoto AM, Bremner WJ. Acceptability of a combination testosterone gel and depomedroxyprogesterone acetate male contraceptive regimen. Contraception. 2007 Mar;75(3):218-23. doi: 10.1016/j.contraception.2006.11.003. Epub 2007 Jan 16. PubMed PMID: 17303493; NIHMSID:NIHMS291938.
Page ST, Matsumoto AM, Bremner WJ. DHEA and testosterone in the elderly. N Engl J Med. 2007 Feb 8;356(6):635; author reply 637. doi: 10.1056/NEJMc063190. PubMed PMID: 17287487; NIHMSID:NIHMS291937.
Amory JK, Page ST, Anawalt BD, Coviello AD, Matsumoto AM, Bremner WJ. Elevated end-of-treatment serum INSL3 is associated with failure to completely suppress spermatogenesis in men receiving male hormonal contraception. J Androl. 2007 Jul-Aug;28(4):548-54. doi: 10.2164/jandrol.106.002345. Epub 2007 Feb 21. PubMed PMID: 17314233; NIHMSID:NIHMS291939.
Amory JK, Coviello AD, Page ST, Anawalt BD, Matsumoto AM, Bremner WJ. Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin-suppressed normal men receiving various dosages of human chorionic gonadotropin. Fertil Steril. 2008 Feb;89(2):380-6. doi: 10.1016/j.fertnstert.2007.02.059. Epub 2007 Apr 26. PubMed PMID: 17462643; PubMed Central PMCID: PMC2674872.
Page ST, Kalhorn TF, Bremner WJ, Anawalt BD, Matsumoto AM, Amory JK. Intratesticular androgens and spermatogenesis during severe gonadotropin suppression induced by male hormonal contraceptive treatment. J Androl. 2007 Sep-Oct;28(5):734-41. doi: 10.2164/jandrol.107.002790. Epub 2007 May 9. PubMed PMID: 17494097; NIHMSID:NIHMS291940.
Mostaghel EA, Page ST, Lin DW, Fazli L, Coleman IM, True LD, Knudsen B, Hess DL, Nelson CC, Matsumoto AM, Bremner WJ, Gleave ME, Nelson PS. Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007 May 15;67(10):5033-41. doi: 10.1158/0008-5472.CAN-06-3332. PubMed PMID: 17510436; NIHMSID:NIHMS291941.
Araujo AB, Kupelian V, Page ST, Handelsman DJ, Bremner WJ, McKinlay JB. Sex steroids and all-cause and cause-specific mortality in men. Arch Intern Med. 2007 Jun 25;167(12):1252-60. doi: 10.1001/archinte.167.12.1252. PubMed PMID: 17592098; NIHMSID:NIHMS291942.
Hall SA, Page ST, Travison TG, Montgomery RB, Link CL, McKinlay JB. Do statins affect androgen levels in men? Results from the Boston area community health survey. Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1587-94. doi: 10.1158/1055-9965.EPI-07-0306. PubMed PMID: 17684132; NIHMSID:NIHMS291943.
Montgomery RB, Goldman B, Tangen CM, Hussain M, Petrylak DP, Page S, Klein EA, Crawford ED, Southwest Oncology Group. Association of body mass index with response and survival in men with metastatic prostate cancer: Southwest Oncology Group trials 8894 and 9916. J Urol. 2007 Nov;178(5):1946-51; discussion 1951. doi: 10.1016/j.juro.2007.07.026. Epub 2007 Sep 17. PubMed PMID: 17868721.
Amory JK, Kalhorn TF, Page ST. Pharmacokinetics and pharmacodynamics of oral testosterone enanthate plus dutasteride for 4 weeks in normal men: implications for male hormonal contraception. J Androl. 2008 May-Jun;29(3):260-71. doi: 10.2164/jandrol.107.004226. Epub 2007 Nov 28. PubMed PMID: 18046048; PubMed Central PMCID: PMC2664381.
Page ST, Bremner WJ, Clark RV, Bush MA, Zhi H, Caricofe RB, Smith PM, Amory JK. Nanomilled oral testosterone plus dutasteride effectively normalizes serum testosterone in normal men with induced hypogonadism. J Androl. 2008 Mar-Apr;29(2):222-7. doi: 10.2164/jandrol.107.002956. Epub 2007 Dec 12. PubMed PMID: 18077826; NIHMSID:NIHMS291945.
Page ST, Mohr BA, Link CL, O'Donnell AB, Bremner WJ, McKinlay JB. Higher testosterone levels are associated with increased high-density lipoprotein cholesterol in men with cardiovascular disease: results from the Massachusetts Male Aging Study. Asian J Androl. 2008 Mar;10(2):193-200. doi: 10.1111/j.1745-7262.2008.00332.x. Epub 2007 Dec 20. PubMed PMID: 18097527; PubMed Central PMCID: PMC2666971.
Page ST, Marck BT, Tolliver JM, Matsumoto AM. Tissue selectivity of the anabolic steroid, 19-nor-4-androstenediol-3beta,17beta-diol in male Sprague Dawley rats: selective stimulation of muscle mass and bone mineral density relative to prostate mass. Endocrinology. 2008 Apr;149(4):1987-93. doi: 10.1210/en.2007-0956. Epub 2007 Dec 20. PubMed PMID: 18096666; PubMed Central PMCID: PMC2276724.
Kalhorn TF, Page ST, Howald WN, Mostaghel EA, Nelson PS. Analysis of testosterone and dihydrotestosterone from biological fluids as the oxime derivatives using high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(19):3200-6. doi: 10.1002/rcm.3205. PubMed PMID: 17764104; NIHMSID:NIHMS291944.
Amory JK, Anawalt BD, Matsumoto AM, Page ST, Bremner WJ, Wang C, Swerdloff RS, Clark RV. The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men. J Urol. 2008 Jun;179(6):2333-8. doi: 10.1016/j.juro.2008.01.145. Epub 2008 Apr 18. PubMed PMID: 18423697; PubMed Central PMCID: PMC2684818.
Page ST, Amory JK, Bremner WJ. Advances in male contraception. Endocr Rev. 2008 Jun;29(4):465-93. doi: 10.1210/er.2007-0041. Epub 2008 Apr 24. Review. PubMed PMID: 18436704; PubMed Central PMCID: PMC2528850.
Page ST, Amory JK, Matsumoto AM. Does testosterone supplementation improve health and function in elderly men?. Nat Clin Pract Endocrinol Metab. 2008 Jul;4(7):374-5. doi: 10.1038/ncpendmet0840. Epub 2008 May 20. PubMed PMID: 18493229; PubMed Central PMCID: PMC2657091.
Roth MY, Amory JK, Page ST. Treatment of male infertility secondary to morbid obesity. Nat Clin Pract Endocrinol Metab. 2008 Jul;4(7):415-9. doi: 10.1038/ncpendmet0844. Epub 2008 Jun 3. PubMed PMID: 18523426; PubMed Central PMCID: PMC2664380.
Wu JD, Lin DW, Page ST, Lundgren AD, True LD, Plymate SR. Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer. Transl Oncol. 2009 Mar;2(1):39-45. doi: 10.1593/tlo.08217. PubMed PMID: 19252750; PubMed Central PMCID: PMC2647701.
Mahabadi V, Amory JK, Swerdloff RS, Bremner WJ, Page ST, Sitruk-Ware R, Christensen PD, Kumar N, Tsong YY, Blithe D, Wang C. Combined transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in men. J Clin Endocrinol Metab. 2009 Jul;94(7):2313-20. doi: 10.1210/jc.2008-2604. Epub 2009 Apr 14. PubMed PMID: 19366848; PubMed Central PMCID: PMC2708961.
Amory JK, Leonard TW, Page ST, O'Toole E, McKenna MJ, Bremner WJ. Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics. Cancer Chemother Pharmacol. 2009 Aug;64(3):641-5. doi: 10.1007/s00280-009-1038-1. Epub 2009 May 29. PubMed PMID: 19479252; PubMed Central PMCID: PMC2721900.
Roth MY, Lin K, Amory JK, Matsumoto AM, Anawalt BD, Snyder CN, Kalhorn TF, Bremner WJ, Page ST. Serum LH correlates highly with intratesticular steroid levels in normal men. J Androl. 2010 Mar-Apr;31(2):138-45. doi: 10.2164/jandrol.109.008391. Epub 2009 Sep 24. PubMed PMID: 19779211; PubMed Central PMCID: PMC2866133.
Attardi BJ, Page ST, Hild SA, Coss CC, Matsumoto AM. Mechanism of action of bolandiol (19-nortestosterone-3beta,17beta-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities. J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):151-61. doi: 10.1016/j.jsbmb.2009.11.008. Epub 2009 Nov 24. PubMed PMID: 19941958; PubMed Central PMCID: PMC2831543.
Wright JL, Page ST, Lin DW, Stanford JL. Male pattern baldness and prostate cancer risk in a population-based case-control study. Cancer Epidemiol. 2010 Apr;34(2):131-5. doi: 10.1016/j.canep.2010.02.003. Epub 2010 Mar 4. PubMed PMID: 20206591; PubMed Central PMCID: PMC2911123.
Snyder CN, Clark RV, Caricofe RB, Bush MA, Roth MY, Page ST, Bremner WJ, Amory JK. Pharmacokinetics of 2 novel formulations of modified-release oral testosterone alone and with finasteride in normal men with experimental hypogonadism. J Androl. 2010 Nov-Dec;31(6):527-35. doi: 10.2164/jandrol.109.009746. Epub 2010 Apr 8. PubMed PMID: 20378927; PubMed Central PMCID: PMC3047498.
Roth MY, Page ST, Lin K, Anawalt BD, Matsumoto AM, Snyder CN, Marck BT, Bremner WJ, Amory JK. Dose-dependent increase in intratesticular testosterone by very low-dose human chorionic gonadotropin in normal men with experimental gonadotropin deficiency. J Clin Endocrinol Metab. 2010 Aug;95(8):3806-13. doi: 10.1210/jc.2010-0360. Epub 2010 May 19. PubMed PMID: 20484472; PubMed Central PMCID: PMC2913032.
What would you like to do?