My Bibliography

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Lange S, Soták M, Hagberg CE, Bagunu G, Vigmo S, Börgeson E. Students at a crossroad: A cross-sectional survey gauging the impact of COVID-19 on medical and biomedical graduates in the United States and Sweden. Biochem Mol Biol Educ. 2023 Sep-Oct;51(5):508-519. doi: 10.1002/bmb.21761. Epub 2023 Jun 24. PubMed PMID: 37354049; PubMed Central PMCID: PMC10592423.

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Soták M, Rajan MR, Clark M, Harms M, Rani A, Kraft JD, Tandio D, Shen T, Borkowski K, Fiehn O, Newman JW, Quiding-Järbrink M, Biörserud C, Apelgren P, Staalesen T, Hagberg CE, Boucher J, Wallenius V, Lange S, Börgeson E. Lipoxins reduce obesity-induced adipose tissue inflammation in 3D-cultured human adipocytes and explant cultures. iScience. 2022 Jul 15;25(7):104602. doi: 10.1016/j.isci.2022.104602. eCollection 2022 Jul 15. PubMed PMID: 35789845; PubMed Central PMCID: PMC9249816.

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Pierantozzi E, Szentesi P, Paolini C, Dienes B, Fodor J, Oláh T, Colombini B, Rassier DE, Rubino EM, Lange S, Rossi D, Csernoch L, Bagni MA, Reggiani C, Sorrentino V. Impaired Intracellular Ca(2+) Dynamics, M-Band and Sarcomere Fragility in Skeletal Muscles of Obscurin KO Mice. Int J Mol Sci. 2022 Jan 24;23(3). doi: 10.3390/ijms23031319. PubMed PMID: 35163243; PubMed Central PMCID: PMC8835721.

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van der Pijl RJ, Domenighetti AA, Sheikh F, Ehler E, Ottenheijm CAC, Lange S. The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles. Biophys Rev. 2021 Oct;13(5):653-677. doi: 10.1007/s12551-021-00836-3. eCollection 2021 Oct. Review. PubMed PMID: 34745373; PubMed Central PMCID: PMC8553726.

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Stronczek C, Lange S, Bullard B, Wolniak S, Börgeson E, Mayans O, Fleming JR. The N2A region of titin has a unique structural configuration. J Gen Physiol. 2021 Jul 5;153(7). doi: 10.1085/jgp.202012766. PubMed PMID: 33836065; PubMed Central PMCID: PMC8042602.

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Liang Y, Lyon RC, Pellman J, Bradford WH, Lange S, Bogomolovas J, Dalton ND, Gu Y, Bobar M, Lee MH, Iwakuma T, Nigam V, Asimaki A, Scheinman M, Peterson KL, Sheikh F. Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Clin Invest. 2021 Jun 1;131(11). doi: 10.1172/JCI137689. PubMed PMID: 33857019; PubMed Central PMCID: PMC8159691.

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Börgeson E, Sotak M, Kraft J, Bagunu G, Biörserud C, Lange S. Challenges in PhD education due to COVID-19 - disrupted supervision or business as usual: a cross-sectional survey of Swedish biomedical sciences graduate students. BMC Med Educ. 2021 May 22;21(1):294. doi: 10.1186/s12909-021-02727-3. PubMed PMID: 34022871; PubMed Central PMCID: PMC8140581.

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Zhou T, Fleming JR, Lange S, Hessel AL, Bogomolovas J, Stronczek C, Grundei D, Ghassemian M, Biju A, Börgeson E, Bullard B, Linke WA, Chen J, Kovermann M, Mayans O. Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism. J Mol Biol. 2021 Apr 30;433(9):166901. doi: 10.1016/j.jmb.2021.166901. Epub 2021 Feb 27. PubMed PMID: 33647290; PubMed Central PMCID: PMC8052292.

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Fleming JR, Rani A, Kraft J, Zenker S, Börgeson E, Lange S. Exploring Obscurin and SPEG Kinase Biology. J Clin Med. 2021 Mar 2;10(5). doi: 10.3390/jcm10050984. PubMed PMID: 33801198; PubMed Central PMCID: PMC7957886.

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Blondelle J, Biju A, Lange S. The Role of Cullin-RING Ligases in Striated Muscle Development, Function, and Disease. Int J Mol Sci. 2020 Oct 26;21(21). doi: 10.3390/ijms21217936. Review. PubMed PMID: 33114658; PubMed Central PMCID: PMC7672578.

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Lange S, Pinotsis N, Agarkova I, Ehler E. The M-band: The underestimated part of the sarcomere. Biochim Biophys Acta Mol Cell Res. 2020 Mar;1867(3):118440. doi: 10.1016/j.bbamcr.2019.02.003. Epub 2019 Feb 7. Review. PubMed PMID: 30738787; PubMed Central PMCID: PMC7023976.

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Rajan MR, Sotak M, Barrenäs F, Shen T, Borkowski K, Ashton NJ, Biörserud C, Lindahl TL, Ramström S, Schöll M, Lindahl P, Fiehn O, Newman JW, Perkins R, Wallenius V, Lange S, Börgeson E. Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum. Sci Rep. 2019 Oct 28;9(1):15385. doi: 10.1038/s41598-019-51673-0. PubMed PMID: 31659186; PubMed Central PMCID: PMC6817872.

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Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Börgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman J, Del Álamo JC, Nigam V. miR-486 is modulated by stretch and increases ventricular growth. JCI Insight. 2019 Sep 12;4(19). doi: 10.1172/jci.insight.125507. PubMed PMID: 31513548; PubMed Central PMCID: PMC6795397.

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Blondelle J, Marrocco V, Clark M, Desmond P, Myers S, Nguyen J, Wright M, Bremner S, Pierantozzi E, Ward S, Estève E, Sorrentino V, Ghassemian M, Lange S. Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Commun Biol. 2019;2:178. doi: 10.1038/s42003-019-0405-7. eCollection 2019. PubMed PMID: 31098411; PubMed Central PMCID: PMC6509138.

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Blondelle J, Tallapaka K, Seto JT, Ghassemian M, Clark M, Laitila JM, Bournazos A, Singer JD, Lange S. Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy. JCI Insight. 2019 Apr 16;5(10). doi: 10.1172/jci.insight.125665. PubMed PMID: 30990797; PubMed Central PMCID: PMC6542616.

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Marrocco V, Bogomolovas J, Ehler E, Dos Remedios CG, Yu J, Gao C, Lange S. PKC and PKN in heart disease. J Mol Cell Cardiol. 2019 Mar;128:212-226. doi: 10.1016/j.yjmcc.2019.01.029. Epub 2019 Feb 8. Review. PubMed PMID: 30742812; PubMed Central PMCID: PMC6408329.

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Ehsan M, Kelly M, Hooper C, Yavari A, Beglov J, Bellahcene M, Ghataorhe K, Poloni G, Goel A, Kyriakou T, Fleischanderl K, Ehler E, Makeyev E, Lange S, Ashrafian H, Redwood C, Davies B, Watkins H, Gehmlich K. Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion. J Mol Cell Cardiol. 2018 Aug;121:287-296. doi: 10.1016/j.yjmcc.2018.07.248. Epub 2018 Jul 23. PubMed PMID: 30048712; PubMed Central PMCID: PMC6117453.

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Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy. J Clin Invest. 2017 Aug 1;127(8):3189-3200. doi: 10.1172/JCI94310. Epub 2017 Jul 24. PubMed PMID: 28737513; PubMed Central PMCID: PMC5531406.

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Blondelle J, Shapiro P, Domenighetti AA, Lange S. Cullin E3 Ligase Activity Is Required for Myoblast Differentiation. J Mol Biol. 2017 Apr 7;429(7):1045-1066. doi: 10.1016/j.jmb.2017.02.012. Epub 2017 Feb 24. PubMed PMID: 28238764; PubMed Central PMCID: PMC5395100.

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Randazzo D, Blaauw B, Paolini C, Pierantozzi E, Spinozzi S, Lange S, Chen J, Protasi F, Reggiani C, Sorrentino V. Exercise-induced alterations and loss of sarcomeric M-line organization in the diaphragm muscle of obscurin knockout mice. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C16-C28. doi: 10.1152/ajpcell.00098.2016. Epub 2016 Oct 26. PubMed PMID: 27784675; PubMed Central PMCID: PMC5283896.

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Bogomolovas J, Fleming JR, Anderson BR, Williams R, Lange S, Simon B, Khan MM, Rudolf R, Franke B, Bullard B, Rigden DJ, Granzier H, Labeit S, Mayans O. Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. Open Biol. 2016 Sep;6(9). doi: 10.1098/rsob.160114. PubMed PMID: 27683155; PubMed Central PMCID: PMC5043576.

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Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E. MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy. Nat Commun. 2016 Jun 29;7:12120. doi: 10.1038/ncomms12120. PubMed PMID: 27353086; PubMed Central PMCID: PMC4931343.

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Mu Y, Jing R, Peter AK, Lange S, Lin L, Zhang J, Ouyang K, Fang X, Veevers J, Zhou X, Evans SM, Cheng H, Chen J. Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival. J Am Heart Assoc. 2015 May 5;4(5). doi: 10.1161/JAHA.115.001950. PubMed PMID: 25944877; PubMed Central PMCID: PMC4599425.

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Blondelle J, Lange S, Greenberg BH, Cowling RT. Cathepsins in heart disease-chewing on the heartache?. Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H974-6. doi: 10.1152/ajpheart.00125.2015. Epub 2015 Mar 6. PubMed PMID: 25747750; PubMed Central PMCID: PMC4578146.

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Banerjee I, Carrion K, Serrano R, Dyo J, Sasik R, Lund S, Willems E, Aceves S, Meili R, Mercola M, Chen J, Zambon A, Hardiman G, Doherty TA, Lange S, del Álamo JC, Nigam V. Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling. J Mol Cell Cardiol. 2015 Feb;79:133-44. doi: 10.1016/j.yjmcc.2014.11.003. Epub 2014 Nov 13. PubMed PMID: 25446186; PubMed Central PMCID: PMC4302020.

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Blondelle J, Lange S. How to Maintain a Working Heart—Waste Disposal and Recycling in Cardiomyocytes. In: Ehler E, editor. Cardiac Cytoarchitecture Springer International Publishing Switzerland: Springer International Publishing AG; 2015. Chapter 12; p.245-309.

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Lun AS, Chen J, Lange S. Probing muscle ankyrin-repeat protein (MARP) structure and function. Anat Rec (Hoboken). 2014 Sep;297(9):1615-29. doi: 10.1002/ar.22968. PubMed PMID: 25125175; PubMed Central PMCID: PMC4135402.

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Lange S, Edström L, Udd B, Gautel M. Reply: Hereditary myopathy with early respiratory failure is caused by mutations in the titin FN3 119 domain. Brain. 2014 Jun;137(Pt 6):e279. doi: 10.1093/brain/awu033. Epub 2014 Feb 24. PubMed PMID: 24569025; PubMed Central PMCID: PMC4032095.

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Lin C, Guo X, Lange S, Liu J, Ouyang K, Yin X, Jiang L, Cai Y, Mu Y, Sheikh F, Ye S, Chen J, Ke Y, Cheng H. Cypher/ZASP is a novel A-kinase anchoring protein. J Biol Chem. 2013 Oct 11;288(41):29403-13. doi: 10.1074/jbc.M113.470708. Epub 2013 Aug 31. PubMed PMID: 23996002; PubMed Central PMCID: PMC3795241.

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Ehler E, Moore-Morris T, Lange S. Isolation and culture of neonatal mouse cardiomyocytes. J Vis Exp. 2013 Sep 6;(79). doi: 10.3791/50154. PubMed PMID: 24056408; PubMed Central PMCID: PMC3857885.

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Lyon RC, Lange S, Sheikh F. Breaking down protein degradation mechanisms in cardiac muscle. Trends Mol Med. 2013 Apr;19(4):239-49. doi: 10.1016/j.molmed.2013.01.005. Epub 2013 Feb 27. Review. PubMed PMID: 23453282; PubMed Central PMCID: PMC3622835.

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Randazzo D, Giacomello E, Lorenzini S, Rossi D, Pierantozzi E, Blaauw B, Reggiani C, Lange S, Peter AK, Chen J, Sorrentino V. Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity. J Cell Biol. 2013 Feb 18;200(4):523-36. doi: 10.1083/jcb.201205118. PubMed PMID: 23420875; PubMed Central PMCID: PMC3575540.

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Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem. 2012 Aug 24;287(35):29273-84. doi: 10.1074/jbc.M112.372839. Epub 2012 Jul 9. PubMed PMID: 22778266; PubMed Central PMCID: PMC3436149.

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Lange S, Perera S, Teh P, Chen J. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Mol Biol Cell. 2012 Jul;23(13):2490-504. doi: 10.1091/mbc.E12-01-0052. Epub 2012 May 9. PubMed PMID: 22573887; PubMed Central PMCID: PMC3386213.

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Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J. Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 3;110(3):456-64. doi: 10.1161/CIRCRESAHA.111.258616. Epub 2011 Dec 8. PubMed PMID: 22158707; PubMed Central PMCID: PMC3739283.

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Iskratsch T, Lange S, Dwyer J, Kho AL, dos Remedios C, Ehler E. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. J Cell Biol. 2010 Dec 13;191(6):1159-72. doi: 10.1083/jcb.201005060. PubMed PMID: 21149568; PubMed Central PMCID: PMC3002041.

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DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One. 2010 Sep 27;5(9):e13039. doi: 10.1371/journal.pone.0013039. PubMed PMID: 20885963; PubMed Central PMCID: PMC2946408.

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Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J. Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet. 2010 Jan 15;19(2):329-41. doi: 10.1093/hmg/ddp499. Epub 2009 Oct 28. PubMed PMID: 19864491; PubMed Central PMCID: PMC2796894.

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Lange S, Ouyang K, Meyer G, Cui L, Cheng H, Lieber RL, Chen J. Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. J Cell Sci. 2009 Aug 1;122(Pt 15):2640-50. doi: 10.1242/jcs.046193. Epub 2009 Jul 7. PubMed PMID: 19584095; PubMed Central PMCID: PMC2909316.

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Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW 2nd, Brown JH, Peterson KL, Omens JH, McCulloch AD, Chen J. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest. 2008 Dec;118(12):3870-80. doi: 10.1172/JCI34472. Epub 2008 Nov 3. PubMed PMID: 19033658; PubMed Central PMCID: PMC2575833.

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Fukuzawa A, Lange S, Holt M, Vihola A, Carmignac V, Ferreiro A, Udd B, Gautel M. Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies. J Cell Sci. 2008 Jun 1;121(11):1841-51. doi: 10.1242/jcs.028019. Epub 2008 May 13. PubMed PMID: 18477606.

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Schoenauer R, Lange S, Hirschy A, Ehler E, Perriard JC, Agarkova I. Myomesin 3, a novel structural component of the M-band in striated muscle. J Mol Biol. 2008 Feb 15;376(2):338-51. doi: 10.1016/j.jmb.2007.11.048. Epub 2007 Nov 22. PubMed PMID: 18177667.

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Pinotsis N, Lange S, Perriard JC, Svergun DI, Wilmanns M. Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin. EMBO J. 2008 Jan 9;27(1):253-64. doi: 10.1038/sj.emboj.7601944. Epub 2007 Dec 6. PubMed PMID: 18059477; PubMed Central PMCID: PMC2206126.

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Sheikh F, Bang ML, Lange S, Chen J. "Z"eroing in on the role of Cypher in striated muscle function, signaling, and human disease. Trends Cardiovasc Med. 2007 Nov;17(8):258-62. doi: 10.1016/j.tcm.2007.09.002. Review. PubMed PMID: 18021935; PubMed Central PMCID: PMC2134983.

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Müller S, Lange S, Gautel M, Wilmanns M. Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin. J Mol Biol. 2007 Aug 10;371(2):469-80. doi: 10.1016/j.jmb.2007.05.055. Epub 2007 May 25. PubMed PMID: 17574571.

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Pinotsis N, Petoukhov M, Lange S, Svergun D, Zou P, Gautel M, Wilmanns M. Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. J Struct Biol. 2006 Aug;155(2):239-50. doi: 10.1016/j.jsb.2006.03.028. Epub 2006 Apr 27. PubMed PMID: 16713295.

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Zou P, Pinotsis N, Lange S, Song YH, Popov A, Mavridis I, Mayans OM, Gautel M, Wilmanns M. Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Nature. 2006 Jan 12;439(7073):229-33. doi: 10.1038/nature04343. PubMed PMID: 16407954.

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Lange S, Ehler E, Gautel M. From A to Z and back? Multicompartment proteins in the sarcomere. Trends Cell Biol. 2006 Jan;16(1):11-8. doi: 10.1016/j.tcb.2005.11.007. Epub 2005 Dec 6. Review. PubMed PMID: 16337382.

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Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, Kristensen J, Brandmeier B, Franzen G, Hedberg B, Gunnarsson LG, Hughes SM, Marchand S, Sejersen T, Richard I, Edström L, Ehler E, Udd B, Gautel M. The kinase domain of titin controls muscle gene expression and protein turnover. Science. 2005 Jun 10;308(5728):1599-603. doi: 10.1126/science.1110463. Epub 2005 Mar 31. PubMed PMID: 15802564.

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Lange S, Himmel M, Auerbach D, Agarkova I, Hayess K, Fürst DO, Perriard JC, Ehler E. Dimerisation of myomesin: implications for the structure of the sarcomeric M-band. J Mol Biol. 2005 Jan 14;345(2):289-98. doi: 10.1016/j.jmb.2004.10.040. PubMed PMID: 15571722.