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  1. Žiniauskaitė A, Ragauskas S, Ghosh AK, Thapa R, Roessler AE, Koulen P, Kalesnykas G, Hakkarainen JJ, Kaja S. Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin, a superoxide dismutase mimetic, reduces disease severity in in vitro and in vivo models for dry-eye disease. Ocul Surf. 2019 Apr;17(2):257-264. doi: 10.1016/j.jtos.2019.02.006. Epub 2019 Feb 23. PubMed PMID: 30807830; PubMed Central PMCID: PMC6570415.
  2. Breuer EK, Fukushiro-Lopes D, Dalheim A, Burnette M, Zartman J, Kaja S, Wells C, Campo L, Curtis KJ, Romero-Moreno R, Littlepage LE, Niebur GL, Hoskins K, Nishimura MI, Gentile S. Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling. Cell Death Dis. 2019 Feb 21;10(3):180. doi: 10.1038/s41419-019-1429-0. PubMed PMID: 30792401; PubMed Central PMCID: PMC6385342.
  3. Rosen SM, Kaja S, De Alba F. Association of Transient Colorblindness With Sildenafil and Tadalafil. JAMA Ophthalmol. 2019 Jan 1;137(1):117-118. doi: 10.1001/jamaophthalmol.2018.4716. PubMed PMID: 30286227.
  4. Žiniauskaite A, Ragauskas S, Hakkarainen JJ, Rich CC, Baumgartner R, Kalesnykas G, Albers DS, Kaja S. Efficacy of Trabodenoson in a Mouse Keratoconjunctivitis Sicca (KCS) Model for Dry-Eye Syndrome. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):3088-3093. doi: 10.1167/iovs.18-24432. PubMed PMID: 30025146.
  5. Ragauskas S, Kielczewski E, Vance J, Kaja S, Kalesnykas G. In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model. J Vis Exp. 2018 Jan 21;(131). doi: 10.3791/56173. PubMed PMID: 29443029; PubMed Central PMCID: PMC5908670.
  6. Fukushiro-Lopes DF, Hegel AD, Rao V, Wyatt D, Baker A, Breuer EK, Osipo C, Zartman JJ, Burnette M, Kaja S, Kouzoukas D, Burris S, Jones WK, Gentile S. Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer. Oncotarget. 2018 Jan 9;9(3):3321-3337. doi: 10.18632/oncotarget.22925. eCollection 2018 Jan 9. PubMed PMID: 29423049; PubMed Central PMCID: PMC5790466.
  7. Huang J, Romero-Suarez S, Lara N, Mo C, Kaja S, Brotto L, Dallas SL, Johnson ML, Jähn K, Bonewald LF, Brotto M. Crosstalk between MLO-Y4 osteocytes and C2C12 muscle cells is mediated by the Wnt/β-catenin pathway. JBMR Plus. 2017 Oct;1(2):86-100. doi: 10.1002/jbm4.10015. Epub 2017 Oct 4. PubMed PMID: 29104955; PubMed Central PMCID: PMC5667655.
  8. Sandoval A, Duran P, Gandini MA, Andrade A, Almanza A, Kaja S, Felix R. Regulation of L-type CaV1.3 channel activity and insulin secretion by the cGMP-PKG signaling pathway. Cell Calcium. 2017 Sep;66:1-9. doi: 10.1016/j.ceca.2017.05.008. Epub 2017 May 15. PubMed PMID: 28807144; PubMed Central PMCID: PMC5776030.
  9. Kaja S, Payne AJ, Naumchuk Y, Koulen P. Quantification of Lactate Dehydrogenase for Cell Viability Testing Using Cell Lines and Primary Cultured Astrocytes. Curr Protoc Toxicol. 2017 May 2;72:2.26.1-2.26.10. doi: 10.1002/cptx.21. PubMed PMID: 28463416; PubMed Central PMCID: PMC5501254.
  10. Maciulaitiene R, Pakuliene G, Kaja S, Pauza DH, Kalesnykas G, Januleviciene I. Glioprotection of Retinal Astrocytes After Intravitreal Administration of Memantine in the Mouse Optic Nerve Crush Model. Med Sci Monit. 2017 Mar 7;23:1173-1179. doi: 10.12659/msm.899699. PubMed PMID: 28265105; PubMed Central PMCID: PMC5352005.
  11. Hakkarainen JJ, Reinisalo M, Ragauskas S, Seppänen A, Kaja S, Kalesnykas G. Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells. Int J Pharm. 2016 Sep 10;511(1):73-78. doi: 10.1016/j.ijpharm.2016.06.135. Epub 2016 Jun 29. PubMed PMID: 27374205.
  12. Means JC, Gerdes BC, Kaja S, Sumien N, Payne AJ, Stark DA, Borden PK, Price JL, Koulen P. Caspase-3-Dependent Proteolytic Cleavage of Tau Causes Neurofibrillary Tangles and Results in Cognitive Impairment During Normal Aging. Neurochem Res. 2016 Sep;41(9):2278-88. doi: 10.1007/s11064-016-1942-9. Epub 2016 May 25. PubMed PMID: 27220334; PubMed Central PMCID: PMC4965284.
  13. Richter F, Koulen P, Kaja S. N-Palmitoylethanolamine Prevents the Run-down of Amplitudes in Cortical Spreading Depression Possibly Implicating Proinflammatory Cytokine Release. Sci Rep. 2016 Mar 23;6:23481. doi: 10.1038/srep23481. PubMed PMID: 27004851; PubMed Central PMCID: PMC4804239.
  14. Kaja S, Payne AJ, Nielsen EØ, Thompson CL, van den Maagdenberg AM, Koulen P, Snutch TP. Differential cerebellar GABAA receptor expression in mice with mutations in CaV2.1 (P/Q-type) calcium channels. Neuroscience. 2015 Sep 24;304:198-208. doi: 10.1016/j.neuroscience.2015.07.044. Epub 2015 Jul 21. PubMed PMID: 26208839; PubMed Central PMCID: PMC4547859.
  15. Kaja S, Payne AJ, Naumchuk Y, Levy D, Zaidi DH, Altman AM, Nawazish S, Ghuman JK, Gerdes BC, Moore MA, Koulen P. Plate reader-based cell viability assays for glioprotection using primary rat optic nerve head astrocytes. Exp Eye Res. 2015 Sep;138:159-66. doi: 10.1016/j.exer.2015.05.023. Epub 2015 Jun 3. PubMed PMID: 26048476; PubMed Central PMCID: PMC4553084.
  16. Kaja S, Sumien N, Shah VV, Puthawala I, Maynard AN, Khullar N, Payne AJ, Forster MJ, Koulen P. Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels. Mol Neurobiol. 2015 Aug;52(1):545-54. doi: 10.1007/s12035-014-8877-4. Epub 2014 Sep 10. PubMed PMID: 25204494; PubMed Central PMCID: PMC4362879.
  17. Rao VR, Perez-Neut M, Kaja S, Gentile S. Voltage-gated ion channels in cancer cell proliferation. Cancers (Basel). 2015 May 22;7(2):849-75. doi: 10.3390/cancers7020813. Review. PubMed PMID: 26010603; PubMed Central PMCID: PMC4491688.
  18. Kaja S, Payne AJ, Singh T, Ghuman JK, Sieck EG, Koulen P. An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience. J Pharmacol Toxicol Methods. 2015 May-Jun;73:1-6. doi: 10.1016/j.vascn.2015.02.001. Epub 2015 Feb 12. PubMed PMID: 25681780; PubMed Central PMCID: PMC4458191.
  19. Kaja S, Shah AA, Haji SA, Patel KB, Naumchuk Y, Zabaneh A, Gerdes BC, Kunjukunju N, Sabates NR, Cassell MA, Lord RK, Pikey KP, Poulose A, Koulen P. Nampt/PBEF/visfatin serum levels: a new biomarker for retinal blood vessel occlusions. Clin Ophthalmol. 2015;9:611-8. doi: 10.2147/OPTH.S80784. eCollection 2015. PubMed PMID: 25897200; PubMed Central PMCID: PMC4396426.
  20. Kaja S, Payne AJ, Patel KR, Naumchuk Y, Koulen P. Differential subcellular Ca2+ signaling in a highly specialized subpopulation of astrocytes. Exp Neurol. 2015 Mar;265:59-68. doi: 10.1016/j.expneurol.2014.12.014. Epub 2014 Dec 24. PubMed PMID: 25542978; PubMed Central PMCID: PMC4346429.
  21. Payne AJ, Kaja S, Koulen P. Regulation of ryanodine receptor-mediated calcium signaling by presenilins. Receptors Clin Investig. 2015;2(1):e449. doi: 10.14800/rci.449. PubMed PMID: 25646163; PubMed Central PMCID: PMC4311261.
  22. McCalley AE, Kaja S, Payne AJ, Koulen P. Resveratrol and calcium signaling: molecular mechanisms and clinical relevance. Molecules. 2014 Jun 5;19(6):7327-40. doi: 10.3390/molecules19067327. Review. PubMed PMID: 24905603; PubMed Central PMCID: PMC4160047.
  23. Payne AJ, Kaja S, Naumchuk Y, Kunjukunju N, Koulen P. Antioxidant drug therapy approaches for neuroprotection in chronic diseases of the retina. Int J Mol Sci. 2014 Jan 27;15(2):1865-86. doi: 10.3390/ijms15021865. Review. PubMed PMID: 24473138; PubMed Central PMCID: PMC3958826.
  24. Nielsen EO, Kaja S. GABAA Receptor Expression in the Forebrain of Ataxic Rolling Nagoya Mice. Biol Med (Aligarh). 2014;6(1). doi: 10.4172/1234-3425.1000198. PubMed PMID: 25309056; PubMed Central PMCID: PMC4191822.
  25. Kaja S, Naumchuk Y, Grillo SL, Borden PK, Koulen P. Differential up-regulation of Vesl-1/Homer 1 protein isoforms associated with decline in visual performance in a preclinical glaucoma model. Vision Res. 2014 Jan;94:16-23. doi: 10.1016/j.visres.2013.10.018. Epub 2013 Nov 9. PubMed PMID: 24219919; PubMed Central PMCID: PMC3890355.
  26. Payne AJ, Gerdes BC, Kaja S, Koulen P. Insert sequence length determines transfection efficiency and gene expression levels in bicistronic mammalian expression vectors. Int J Biochem Mol Biol. 2013;4(4):201-8. eCollection 2013. PubMed PMID: 24380024; PubMed Central PMCID: PMC3867706.
  27. Payne AJ, Gerdes BC, Naumchuk Y, McCalley AE, Kaja S, Koulen P. Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines. Exp Neurol. 2013 Dec;250:143-50. doi: 10.1016/j.expneurol.2013.09.001. Epub 2013 Sep 9. PubMed PMID: 24029002; PubMed Central PMCID: PMC3843983.
  28. Kaja S, Sumien N, Borden PK, Khullar N, Iqbal M, Collins JL, Forster MJ, Koulen P. Homer-1a immediate early gene expression correlates with better cognitive performance in aging. Age (Dordr). 2013 Oct;35(5):1799-808. doi: 10.1007/s11357-012-9479-6. Epub 2012 Oct 11. PubMed PMID: 23054826; PubMed Central PMCID: PMC3776093.
  29. Payne AJ, Kaja S, Sabates NR, Koulen P. A case for neuroprotection in ophthalmology: developments in translational research. Mo Med. 2013 Sep-Oct;110(5):429-36. Review. PubMed PMID: 24279196; PubMed Central PMCID: PMC3973483.
  30. Romero-Suarez S, Mo C, Touchberry C, Lara N, Baker K, Craig R, Brotto L, Andresen J, Wacker M, Kaja S, Abreu E, Dillmann W, Mestril R, Brotto M, Nosek T. Hyperthermia: from diagnostic and treatments to new discoveries. Recent Pat Biotechnol. 2012 Dec;6(3):172-83. PubMed PMID: 23092438.
  31. Kaja S, Hilgenberg JD, Collins JL, Shah AA, Wawro D, Zimmerman S, Magnusson R, Koulen P. Detection of novel biomarkers for ovarian cancer with an optical nanotechnology detection system enabling label-free diagnostics. J Biomed Opt. 2012 Aug;17(8):081412-1. doi: 10.1117/1.JBO.17.8.081412. PubMed PMID: 23224173; PubMed Central PMCID: PMC3381041.
  32. Chhablani J, Kaja S, Shah VA. Smartphones in ophthalmology. Indian J Ophthalmol. 2012 Mar-Apr;60(2):127-31. doi: 10.4103/0301-4738.94054. PubMed PMID: 22446908; PubMed Central PMCID: PMC3339072.
  33. Kaja S, Goad DL, Ali F, Abraham A, Rebenitsch RL, Teymoorian S, Krishna R, Koulen P. Evaluation of tensile strength of tissue adhesives and sutures for clear corneal incisions using porcine and bovine eyes, with a novel standardized testing platform. Clin Ophthalmol. 2012;6:305-9. doi: 10.2147/OPTH.S29859. Epub 2012 Feb 28. PubMed PMID: 22399842; PubMed Central PMCID: PMC3295627.
  34. Kaja S, Mafe OA, Parikh RA, Kandula P, Reddy CA, Gregg EV, Xin H, Mitchell P, Grillo MA, Koulen P. Distribution and function of polycystin-2 in mouse retinal ganglion cells. Neuroscience. 2012 Jan 27;202:99-107. doi: 10.1016/j.neuroscience.2011.11.047. Epub 2011 Dec 2. PubMed PMID: 22155264; PubMed Central PMCID: PMC3268838.
  35. Burroughs SL, Duncan RS, Rayudu P, Kandula P, Payne AJ, Clark JL, Koulen P, Kaja S. Plate reader-based assays for measuring cell viability, neuroprotection and calcium in primary neuronal cultures. J Neurosci Methods. 2012 Jan 15;203(1):141-5. doi: 10.1016/j.jneumeth.2011.09.007. Epub 2011 Sep 24. PubMed PMID: 21968036; PubMed Central PMCID: PMC3221776.
  36. Kaja S, Hilgenberg JD, Rybalchenko V, Medina-Ortiz WE, Gregg EV, Koulen P. Polycystin-2 expression and function in adult mouse lacrimal acinar cells. Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5605-11. doi: 10.1167/iovs.10-7114. PubMed PMID: 21508103; PubMed Central PMCID: PMC3176037.
  37. Burroughs SL, Kaja S, Koulen P. Quantification of deficits in spatial visual function of mouse models for glaucoma. Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3654-9. doi: 10.1167/iovs.10-7106. PubMed PMID: 21330670; PubMed Central PMCID: PMC3109046.
  38. Garg P, Duncan RS, Kaja S, Zabaneh A, Chapman KD, Koulen P. Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a rodent model for stroke. Neurosci Lett. 2011 Apr 4;492(3):134-8. doi: 10.1016/j.neulet.2011.01.073. Epub 2011 Feb 4. PubMed PMID: 21296126; PubMed Central PMCID: PMC3057422.
  39. Kaja S, Duncan RS, Longoria S, Hilgenberg JD, Payne AJ, Desai NM, Parikh RA, Burroughs SL, Gregg EV, Goad DL, Koulen P. Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors. Neuroscience. 2011 Feb 23;175:281-91. doi: 10.1016/j.neuroscience.2010.11.010. Epub 2010 Nov 11. PubMed PMID: 21075175; PubMed Central PMCID: PMC3038464.
  40. Kaja S, Hilgenberg JD, Everett E, Olitsky SE, Gossage J, Koulen P. Effects of dilution and prolonged storage with preservative in a polyethylene container on Bevacizumab (Avastin™) for topical delivery as a nasal spray in anti-hereditary hemorrhagic telangiectasia and related therapies. Hum Antibodies. 2011;20(3-4):95-101. doi: 10.3233/HAB-2011-0244. PubMed PMID: 22129679; PubMed Central PMCID: PMC3264393.
  41. Kaja S, Van de Ven RC, Broos LA, Frants RR, Ferrari MD, Van den Maagdenberg AM, Plomp JJ. Severe and progressive neurotransmitter release aberrations in familial hemiplegic migraine type 1 Cacna1a S218L knock-in mice. J Neurophysiol. 2010 Sep;104(3):1445-55. doi: 10.1152/jn.00012.2010. Epub 2010 Jul 14. PubMed PMID: 20631222.
  42. Garg P, Duncan RS, Kaja S, Koulen P. Intracellular mechanisms of N-acylethanolamine-mediated neuroprotection in a rat model of stroke. Neuroscience. 2010 Mar 10;166(1):252-62. doi: 10.1016/j.neuroscience.2009.11.069. Epub 2009 Dec 3. PubMed PMID: 19963043; PubMed Central PMCID: PMC2830814.
  43. Duncan RS, Goad DL, Grillo MA, Kaja S, Payne AJ, Koulen P. Control of intracellular calcium signaling as a neuroprotective strategy. Molecules. 2010 Mar 3;15(3):1168-95. doi: 10.3390/molecules15031168. Review. PubMed PMID: 20335972; PubMed Central PMCID: PMC2847496.
  44. van den Maagdenberg AM, Pizzorusso T, Kaja S, Terpolilli N, Shapovalova M, Hoebeek FE, Barrett CF, Gherardini L, van de Ven RC, Todorov B, Broos LA, Tottene A, Gao Z, Fodor M, De Zeeuw CI, Frants RR, Plesnila N, Plomp JJ, Pietrobon D, Ferrari MD. High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice. Ann Neurol. 2010 Jan;67(1):85-98. doi: 10.1002/ana.21815. PubMed PMID: 20186955.
  45. Plomp JJ, van den Maagdenberg AM, Kaja S. The ataxic Cacna1a-mutant mouse rolling nagoya: an overview of neuromorphological and electrophysiological findings. Cerebellum. 2009 Sep;8(3):222-30. doi: 10.1007/s12311-009-0117-5. Epub 2009 May 30. Review. PubMed PMID: 19484318; PubMed Central PMCID: PMC2734259.
  46. Kaja S, Van De Ven RC, Frants RR, Ferrari MD, Van Den Maagdenberg AM, Plomp JJ. Reduced ACh release at neuromuscular synapses of heterozygous leaner Ca(v)2.1-mutant mice. Synapse. 2008 May;62(5):337-44. doi: 10.1002/syn.20490. PubMed PMID: 18293354.
  47. Kaja S, Hann V, Payne HL, Thompson CL. Aberrant cerebellar granule cell-specific GABAA receptor expression in the epileptic and ataxic mouse mutant, Tottering. Neuroscience. 2007 Aug 10;148(1):115-25. doi: 10.1016/j.neuroscience.2007.03.055. Epub 2007 Jul 5. PubMed PMID: 17614209.
  48. van de Ven RC, Kaja S, Plomp JJ, Frants RR, van den Maagdenberg AM, Ferrari MD. Genetic models of migraine. Arch Neurol. 2007 May;64(5):643-6. doi: 10.1001/archneur.64.5.643. Review. PubMed PMID: 17502463.
  49. Kaja S, Todorov B, van de Ven RC, Ferrari MD, Frants RR, van den Maagdenberg AM, Plomp JJ. Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction. Brain Res. 2007 Apr 27;1143:92-101. doi: 10.1016/j.brainres.2007.01.063. Epub 2007 Jan 26. PubMed PMID: 17320843.
  50. Kaja S, van de Ven RC, van Dijk JG, Verschuuren JJ, Arahata K, Frants RR, Ferrari MD, van den Maagdenberg AM, Plomp JJ. Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a-mutant mouse rolling Nagoya. Eur J Neurosci. 2007 Apr;25(7):2009-20. doi: 10.1111/j.1460-9568.2007.05438.x. PubMed PMID: 17439489.