My Bibliography

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Bhosale RS, Chakraborty A, Wong TY, Masal DP, Choudhury R, Srivastava S, Reddy DS, Aldrich CC, Kamat SS, Mohanty D, Gokhale RS. Enzymatic Pathway for Kupyaphore Degradation in Mycobacterium tuberculosis: Mechanism of Metal Homeostasis and Turnover. ACS Chem Biol. 2025 Jul 18;20(7):1492-1504. doi: 10.1021/acschembio.5c00078. Epub 2025 Jun 29. PubMed PMID: 40583177.

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Garde S, Selvaraj H, Chandramouli A, Reddy GS, Bahety D, Chodisetti PK, Kamat SS, Reddy M. A conserved editing mechanism for the fidelity of bacterial cell wall biosynthesis. Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2505676122. doi: 10.1073/pnas.2505676122. Epub 2025 Jul 9. PubMed PMID: 40632566.

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Shanbhag K, Mhetre AB, Saharan O, Devarajan A, Rai A, Madhusudhan MS, Chakrapani H, Kamat SS. Chemoproteomics identifies protein ligands for monoacylglycerol lipids. Commun Chem. 2025 Jul 4;8(1):197. doi: 10.1038/s42004-025-01589-w. PubMed PMID: 40615626; PubMed Central PMCID: PMC12227648.

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Manna S, Gupta SM, Bora P, Chakraborty A, Kumar TA, Kamat SS, Chakrapani H. Tandem Biocatalysis to Generate Hydrogen Sulfide and Promote Endogenous Antioxidant Response. Angew Chem Int Ed Engl. 2025 Jun 10;64(24):e202502917. doi: 10.1002/anie.202502917. Epub 2025 Apr 10. PubMed PMID: 40170193.

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Kapoor Y, Khurana H, Dutta D, Chakraborty A, Priya A, Singh A, Kamat SS, Dhar N, Pucadyil TJ, Nandicoori VK. Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria. Elife. 2025 May 22;14. doi: 10.7554/eLife.104268. PubMed PMID: 40402572; PubMed Central PMCID: PMC12097788.

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Shambhavi S, Mondal S, Chakraborty A, Shukla N, Panda BK, Kumar S, Kinatukara P, Pal B, Kamat SS, Sankaranarayanan R. Emergence of Dip2-mediated specific DAG-based PKC signalling axis in eukaryotes. Elife. 2025 May 6;14. doi: 10.7554/eLife.104011. PubMed PMID: 40327034; PubMed Central PMCID: PMC12055004.

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Chakraborty A, Devarajan A, Kumar K, C S R, Madhusudhan MS, Ratnaparkhi GS, Kamat SS. Bioinformatics Analysis Identifies Sequence Determinants of Enzymatic Activity for the PHARC-Associated Lipase ABHD12. Biochemistry. 2025 Apr 15;64(8):1852-1863. doi: 10.1021/acs.biochem.4c00865. Epub 2025 Mar 26. PubMed PMID: 40138185.

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Mondal A, Nandi S, Singh V, Chakraborty A, Banerjee I, Sen S, Gadad SS, Roy S, Kamat SS, Das C. TCF7l2 Regulates Fatty Acid Chain Elongase HACD3 during Lipid-Induced Stress. Biochemistry. 2025 Apr 15;64(8):1828-1840. doi: 10.1021/acs.biochem.4c00491. Epub 2025 Apr 2. PubMed PMID: 40172138.

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Jog E, Jainarayanan AK, La Ferlita A, Chakraborty A, Dalwai A, Yahya S, Shivashankar A, Choudhary BS, Chandramouli A, Kazi M, Jain D, Khapare N, B A, Khan BK, Gera P, Patil P, Thorat R, Verma N, Sehgal L, Saklani A, Kamat SS, Dalal SN, Chaudhary N. Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer. Redox Biol. 2025 Feb;79:103458. doi: 10.1016/j.redox.2024.103458. Epub 2024 Dec 11. PubMed PMID: 39705849; PubMed Central PMCID: PMC11729006.

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Chakraborty A, Punnamraju P, Sajeevan T, Kaur A, Kolthur-Seetharam U, Kamat SS. Identification of ABHD6 as a lysophosphatidylserine lipase in the mammalian liver and kidneys. J Biol Chem. 2025 Feb;301(2):108157. doi: 10.1016/j.jbc.2025.108157. Epub 2025 Jan 4. PubMed PMID: 39761854; PubMed Central PMCID: PMC11808726.

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Vaidya K, Rodrigues G, Gupta S, Devarajan A, Yeolekar M, Madhusudhan MS, Kamat SS. Identification of sequence determinants for the ABHD14 enzymes. Proteins. 2025 Jan;93(1):255-266. doi: 10.1002/prot.26632. Epub 2023 Nov 16. PubMed PMID: 37974539.

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Alkhalaf LM, Arrowsmith C, Balskus EP, Bergamini G, Bhandari R, Chang CJ, Chen P, Chen X, Ciulli A, Cricco JA, Davis BG, Delbianco M, Dudareva N, Dueber E, Ferguson F, de Giuseppe PO, Hamachi I, Hammond MC, Hatzios SK, Do Heo W, Janet JP, Kamat SS, Knapp S, Krishnan Y, Lang K, Laraia L, Leveson-Gower RB, Li XD, Liu DR, Liu MF, London N, Mahanta N, Mayor-Ruiz C, Muir T, Murakami MT, Rhee HW, Robers M, Satz A, Schulman BA, Shen B, Shoichet B, Strauss E, Suzuki T, Tiwary P, Waldmann H, Ward TR, Weeks A, Weerapana E, Winter G. Thoughts for the future. Nat Chem Biol. 2025 Jan;21(1):6-15. doi: 10.1038/s41589-024-01802-2. PubMed PMID: 39719500.

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Sinha A, Saini KK, Chandramouli A, Tripathi K, Khan MA, Satrusal SR, Verma A, Mandal B, Rai P, Meena S, Nengroo MA, Singh MP, Bhushan NS, Vasudevan M, Singhai A, Singh K, Mishra AK, Kamat SS, Datta D. ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2408049121. doi: 10.1073/pnas.2408049121. Epub 2024 Dec 19. PubMed PMID: 39700137; PubMed Central PMCID: PMC11670210.

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Kumar K, Pazare M, Ratnaparkhi GS, Kamat SS. CG17192 is a Phospholipase That Regulates Signaling Lipids in the Drosophila Gut upon Infection. Biochemistry. 2024 Nov 19;63(22):3000-3010. doi: 10.1021/acs.biochem.4c00579. Epub 2024 Oct 23. PubMed PMID: 39442931.

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Chandramouli A, Kamat SS. A Facile LC-MS Method for Profiling Cholesterol and Cholesteryl Esters in Mammalian Cells and Tissues. Biochemistry. 2024 Sep 17;63(18):2300-2309. doi: 10.1021/acs.biochem.4c00160. Epub 2024 Jul 10. PubMed PMID: 38986142.

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Chakraborty A, Kamat SS. Lysophosphatidylserine: A Signaling Lipid with Implications in Human Diseases. Chem Rev. 2024 May 8;124(9):5470-5504. doi: 10.1021/acs.chemrev.3c00701. Epub 2024 Apr 12. Review. PubMed PMID: 38607675.

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Talwadekar M, Khatri S, Balaji C, Chakraborty A, Basak NP, Kamat SS, Kolthur-Seetharam U. Metabolic transitions regulate global protein fatty acylation. J Biol Chem. 2024 Jan;300(1):105563. doi: 10.1016/j.jbc.2023.105563. Epub 2023 Dec 13. PubMed PMID: 38101568; PubMed Central PMCID: PMC10808961.

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Sen D, Maniyadath B, Chowdhury S, Kaur A, Khatri S, Chakraborty A, Mehendale N, Nadagouda S, Sandra US, Kamat SS, Kolthur-Seetharam U. Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies. iScience. 2023 Jul 21;26(7):107128. doi: 10.1016/j.isci.2023.107128. eCollection 2023 Jul 21. PubMed PMID: 37416476; PubMed Central PMCID: PMC10320512.

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Saharan O, Kamat SS. Mapping lipid pathways during phagocytosis. Biochem Soc Trans. 2023 Jun 28;51(3):1279-1287. doi: 10.1042/BST20221424. Review. PubMed PMID: 37314030.

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Kumari P, Kaul G, Kumar TA, Akhir A, Shukla M, Sharma S, Kamat SS, Chopra S, Chakrapani H. Heterocyclic Diaryliodonium-Based Inhibitors of Carbapenem-Resistant Acinetobacter baumannii. Microbiol Spectr. 2023 Mar 28;11(2):e0477322. doi: 10.1128/spectrum.04773-22. [Epub ahead of print] PubMed PMID: 36976008; PubMed Central PMCID: PMC10101131.

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Mehdiratta K, Nain S, Sharma M, Singh S, Srivastava S, Dhamale BD, Mohanty D, Kamat SS, Natarajan VT, Sharma R, Gokhale RS. Respiratory Quinone Switches from Menaquinone to Polyketide Quinone during the Development Cycle in Streptomyces sp. Strain MNU77. Microbiol Spectr. 2023 Feb 14;11(1):e0259722. doi: 10.1128/spectrum.02597-22. Epub 2022 Dec 12. PubMed PMID: 36507669; PubMed Central PMCID: PMC9927152.

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Shanbhag K, Sharma K, Kamat SS. Photoreactive bioorthogonal lipid probes and their applications in mammalian biology. RSC Chem Biol. 2023 Jan 4;4(1):37-46. doi: 10.1039/d2cb00174h. eCollection 2023 Jan 4. PubMed PMID: 36685253; PubMed Central PMCID: PMC9811504.

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Rajendran A, Soory A, Khandelwal N, Ratnaparkhi G, Kamat SS. A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals. J Biol Chem. 2022 Jul;298(7):102128. doi: 10.1016/j.jbc.2022.102128. Epub 2022 Jun 11. PubMed PMID: 35700823; PubMed Central PMCID: PMC9270251.

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Mondal S, Kinatukara P, Singh S, Shambhavi S, Patil GS, Dubey N, Singh SH, Pal B, Shekar PC, Kamat SS, Sankaranarayanan R. DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes. Elife. 2022 Jun 29;11. doi: 10.7554/eLife.77665. PubMed PMID: 35766356; PubMed Central PMCID: PMC9342972.

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Kumar S, Khan MZ, Khandelwal N, Chongtham C, Singha B, Dabla A, Behera D, Singh A, Gopal B, Arimbasseri GA, Kamat SS, Nandicoori VK. Mycobacterium tuberculosis Transcription Factor EmbR Regulates the Expression of Key Virulence Factors That Aid in Ex Vivo and In Vivo Survival. mBio. 2022 Jun 28;13(3):e0383621. doi: 10.1128/mbio.03836-21. Epub 2022 Apr 26. PubMed PMID: 35471080; PubMed Central PMCID: PMC9239209.

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Mehdiratta K, Singh S, Sharma S, Bhosale RS, Choudhury R, Masal DP, Manocha A, Dhamale BD, Khan N, Asokachandran V, Sharma P, Ikeh M, Brown AC, Parish T, Ojha AK, Michael JS, Faruq M, Medigeshi GR, Mohanty D, Reddy DS, Natarajan VT, Kamat SS, Gokhale RS. Kupyaphores are zinc homeostatic metallophores required for colonization of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8). doi: 10.1073/pnas.2110293119. PubMed PMID: 35193957; PubMed Central PMCID: PMC8872721.

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Mehendale N, Mallik R, Kamat SS. Mapping Sphingolipid Metabolism Pathways during Phagosomal Maturation. ACS Chem Biol. 2021 Dec 17;16(12):2757-2765. doi: 10.1021/acschembio.1c00393. Epub 2021 Oct 14. PubMed PMID: 34647453; PubMed Central PMCID: PMC7612119.

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Singh S, Kamat SS. The loss of enzymatic activity of the PHARC-associated lipase ABHD12 results in increased phagocytosis that causes neuroinflammation. Eur J Neurosci. 2021 Nov;54(10):7442-7457. doi: 10.1111/ejn.15516. Epub 2021 Nov 11. PubMed PMID: 34727579; PubMed Central PMCID: PMC7612011.

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Bora P, Manna S, Nair MA, Sathe RRM, Singh S, Sreyas Adury VS, Gupta K, Mukherjee A, Saini DK, Kamat SS, Hazra AB, Chakrapani H. Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation. Chem Sci. 2021 Oct 13;12(39):12939-12949. doi: 10.1039/d1sc03828a. eCollection 2021 Oct 13. PubMed PMID: 34745524; PubMed Central PMCID: PMC8513928.

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Khandelwal N, Shaikh M, Mhetre A, Singh S, Sajeevan T, Joshi A, Balaji KN, Chakrapani H, Kamat SS. Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs. Cell Chem Biol. 2021 Aug 19;28(8):1169-1179.e6. doi: 10.1016/j.chembiol.2021.01.008. Epub 2021 Feb 10. PubMed PMID: 33571455; PubMed Central PMCID: PMC7611549.

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Kumar K, Mhetre A, Ratnaparkhi GS, Kamat SS. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Biochemistry. 2021 Apr 27;60(16):1312-1324. doi: 10.1021/acs.biochem.1c00171. Epub 2021 Apr 7. PubMed PMID: 33827210; PubMed Central PMCID: PMC7610703.

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Voices of chemical biology. Nat Chem Biol. 2021 Jan;17(1):1-4. doi: 10.1038/s41589-020-00714-1. PubMed PMID: 33328655.

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Kinatukara P, Subramaniyan PS, Patil GS, Shambhavi S, Singh S, Mhetre A, Madduri MK, Soundararajan A, Patel KD, Shekar PC, Kamat SS, Kumar S, Sankaranarayanan R. Peri-natal growth retardation rate and fat mass accumulation in mice lacking Dip2A is dependent on the dietary composition. Transgenic Res. 2020 Dec;29(5-6):553-562. doi: 10.1007/s11248-020-00219-6. Epub 2020 Nov 13. PubMed PMID: 33184751.

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Lote-Oke R, Pawar J, Kulkarni S, Sanas P, Kajale N, Gondhalekar K, Khadilkar V, Kamat S, Khadilkar A. A LC-MS method for 25-hydroxy-vitamin D3 measurements from dried blood spots for an epidemiological survey in India. Sci Rep. 2020 Nov 16;10(1):19873. doi: 10.1038/s41598-020-76955-w. PubMed PMID: 33199793; PubMed Central PMCID: PMC7670412.

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Shanbhag K, Mhetre A, Khandelwal N, Kamat SS. The Lysophosphatidylserines-An Emerging Class of Signalling Lysophospholipids. J Membr Biol. 2020 Oct;253(5):381-397. doi: 10.1007/s00232-020-00133-2. Epub 2020 Aug 7. Review. PubMed PMID: 32767057; PubMed Central PMCID: PMC7116134.

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Singh S, Joshi A, Kamat SS. Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC. Biochemistry. 2020 Jun 23;59(24):2299-2311. doi: 10.1021/acs.biochem.0c00349. Epub 2020 Jun 3. PubMed PMID: 32462874; PubMed Central PMCID: PMC7311203.

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Voices of chemical biology. Nat Chem Biol. 2020 Jun;16(6):598-599. doi: 10.1038/s41589-020-0543-8. PubMed PMID: 32444836.

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Chattopadhyay T, Maniyadath B, Bagul HP, Chakraborty A, Shukla N, Budnar S, Rajendran A, Shukla A, Kamat SS, Kolthur-Seetharam U. Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6890-6900. doi: 10.1073/pnas.1909943117. Epub 2020 Mar 9. PubMed PMID: 32152092; PubMed Central PMCID: PMC7104039.

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Rajendran A, Vaidya K, Mendoza J, Bridwell-Rabb J, Kamat SS. Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme. Biochemistry. 2020 Jan 21;59(2):183-196. doi: 10.1021/acs.biochem.9b00703. Epub 2019 Sep 13. PubMed PMID: 31478652; PubMed Central PMCID: PMC6976303.

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Schepartz A. Introducing "Future of Biochemistry 2020: The Asia-Pacific Issue". Biochemistry. 2020 Jan 14;59(1):1-7. doi: 10.1021/acs.biochem.9b01113. PubMed PMID: 31931576.

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Kumar M, Ojha S, Rai P, Joshi A, Kamat SS, Mallik R. Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver. J Cell Biol. 2019 Nov 4;218(11):3697-3713. doi: 10.1083/jcb.201903102. Epub 2019 Oct 11. PubMed PMID: 31604801; PubMed Central PMCID: PMC6829650.

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Kulkarni A, Soni I, Kelkar DS, Dharmaraja AT, Sankar RK, Beniwal G, Rajendran A, Tamhankar S, Chopra S, Kamat SS, Chakrapani H. Chemoproteomics of an Indole-Based Quinone Epoxide Identifies Druggable Vulnerabilities in Vancomycin-Resistant Staphylococcus aureus. J Med Chem. 2019 Jul 25;62(14):6785-6795. doi: 10.1021/acs.jmedchem.9b00774. Epub 2019 Jul 15. PubMed PMID: 31241934; PubMed Central PMCID: PMC6660313.

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Malik SA, Acharya JD, Mehendale NK, Kamat SS, Ghaskadbi SS. Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation. Free Radic Res. 2019 Jul;53(7):815-827. doi: 10.1080/10715762.2019.1635252. Epub 2019 Jul 10. PubMed PMID: 31223033; PubMed Central PMCID: PMC6675602.

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Chaplot K, Pimpale L, Ramalingam B, Deivasigamani S, Kamat SS, Ratnaparkhi GS. SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis. Dis Model Mech. 2019 Feb 7;12(2). doi: 10.1242/dmm.033803. PubMed PMID: 30635270; PubMed Central PMCID: PMC6398501.

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Kelkar DS, Ravikumar G, Mehendale N, Singh S, Joshi A, Sharma AK, Mhetre A, Rajendran A, Chakrapani H, Kamat SS. A chemical-genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase. Nat Chem Biol. 2019 Feb;15(2):169-178. doi: 10.1038/s41589-018-0195-0. Epub 2019 Jan 14. PubMed PMID: 30643283; PubMed Central PMCID: PMC6420073.

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Abhyankar V, Kaduskar B, Kamat SS, Deobagkar D, Ratnaparkhi GS. Drosophila DNA/RNA methyltransferase contributes to robust host defense in aging animals by regulating sphingolipid metabolism. J Exp Biol. 2018 Nov 16;221(Pt 22). doi: 10.1242/jeb.187989. PubMed PMID: 30254027; PubMed Central PMCID: PMC6258898.

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Joshi A, Shaikh M, Singh S, Rajendran A, Mhetre A, Kamat SS. Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids. J Biol Chem. 2018 Nov 2;293(44):16953-16963. doi: 10.1074/jbc.RA118.005640. Epub 2018 Sep 20. PubMed PMID: 30237167; PubMed Central PMCID: PMC6217928.

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Pathak D, Mehendale N, Singh S, Mallik R, Kamat SS. Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis. ACS Chem Biol. 2018 Aug 17;13(8):2280-2287. doi: 10.1021/acschembio.8b00438. Epub 2018 Jul 13. PubMed PMID: 29963848; PubMed Central PMCID: PMC6102644.

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Ulrich EC, Kamat SS, Hove-Jensen B, Zechel DL. Methylphosphonic Acid Biosynthesis and Catabolism in Pelagic Archaea and Bacteria. Methods Enzymol. 2018;605:351-426. doi: 10.1016/bs.mie.2018.01.039. Epub 2018 May 3. Review. PubMed PMID: 29909833.

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Rai P, Kumar M, Sharma G, Barak P, Das S, Kamat SS, Mallik R. Kinesin-dependent mechanism for controlling triglyceride secretion from the liver. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12958-12963. doi: 10.1073/pnas.1713292114. Epub 2017 Nov 20. PubMed PMID: 29158401; PubMed Central PMCID: PMC5724275.