My Bibliography

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Vallianatos CN, Farrehi C, Friez MJ, Burmeister M, Keegan CE, Iwase S. Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability. Front Mol Neurosci. 2018;11:104. doi: 10.3389/fnmol.2018.00104. eCollection 2018. PubMed PMID: 29670509; PubMed Central PMCID: PMC5893713.

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Porter RS, Jaamour F, Iwase S. Neuron-specific alternative splicing of transcriptional machineries: Implications for neurodevelopmental disorders. Mol Cell Neurosci. 2018 Mar;87:35-45. doi: 10.1016/j.mcn.2017.10.006. Epub 2017 Dec 15. Review. PubMed PMID: 29254826; PubMed Central PMCID: PMC5828955.

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Iwase S, Martin DM. Chromatin in nervous system development and disease. Mol Cell Neurosci. 2018 Mar;87:1-3. doi: 10.1016/j.mcn.2017.12.006. Epub 2017 Dec 15. PubMed PMID: 29248671; PubMed Central PMCID: PMC6591722.

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Yao H, Hill SF, Skidmore JM, Sperry ED, Swiderski DL, Sanchez GJ, Bartels CF, Raphael Y, Scacheri PC, Iwase S, Martin DM. CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development. JCI Insight. 2018 Feb 22;3(4). doi: 10.1172/jci.insight.97440. eCollection 2018 Feb 22. PubMed PMID: 29467333; PubMed Central PMCID: PMC5916250.

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Choi EK, Nguyen TT, Gupta N, Iwase S, Seo YA. Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders. Sci Rep. 2018 Feb 16;8(1):3163. doi: 10.1038/s41598-018-21464-0. PubMed PMID: 29453449; PubMed Central PMCID: PMC5816659.

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Porter RS, Murata-Nakamura Y, Nagasu H, Kim HG, Iwase S. Transcriptome Analysis Revealed Impaired cAMP Responsiveness in PHF21A-Deficient Human Cells. Neuroscience. 2018 Feb 1;370:170-180. doi: 10.1016/j.neuroscience.2017.05.031. Epub 2017 May 29. PubMed PMID: 28571721; PubMed Central PMCID: PMC5708152.

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Iwase S, Bérubé NG, Zhou Z, Kasri NN, Battaglioli E, Scandaglia M, Barco A. Epigenetic Etiology of Intellectual Disability. J Neurosci. 2017 Nov 8;37(45):10773-10782. doi: 10.1523/JNEUROSCI.1840-17.2017. Review. PubMed PMID: 29118205; PubMed Central PMCID: PMC5678009.

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Scandaglia M, Lopez-Atalaya JP, Medrano-Fernandez A, Lopez-Cascales MT, Del Blanco B, Lipinski M, Benito E, Olivares R, Iwase S, Shi Y, Barco A. Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons. Cell Rep. 2017 Oct 3;21(1):47-59. doi: 10.1016/j.celrep.2017.09.014. PubMed PMID: 28978483; PubMed Central PMCID: PMC5679733.

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Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T, Kashihara N. Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice. Sci Rep. 2017 Aug 18;7(1):8801. doi: 10.1038/s41598-017-08054-2. PubMed PMID: 28821730; PubMed Central PMCID: PMC5562821.

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Garay PM, Wallner MA, Iwase S. Yin-yang actions of histone methylation regulatory complexes in the brain. Epigenomics. 2016 Dec;8(12):1689-1708. doi: 10.2217/epi-2016-0090. Epub 2016 Nov 18. Review. PubMed PMID: 27855486; PubMed Central PMCID: PMC5289040.

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Wei G, Deng X, Agarwal S, Iwase S, Disteche C, Xu J. Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells. J Mol Neurosci. 2016 Sep;60(1):33-45. doi: 10.1007/s12031-016-0770-3. Epub 2016 Jul 16. PubMed PMID: 27421841; PubMed Central PMCID: PMC5412133.

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Labonne JD, Lee KH, Iwase S, Kong IK, Diamond MP, Layman LC, Kim CH, Kim HG. An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability. Hum Genet. 2016 Jul;135(7):757-71. doi: 10.1007/s00439-016-1668-4. Epub 2016 Apr 22. PubMed PMID: 27106595.

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Iwase S, Brookes E, Agarwal S, Badeaux AI, Ito H, Vallianatos CN, Tomassy GS, Kasza T, Lin G, Thompson A, Gu L, Kwan KY, Chen C, Sartor MA, Egan B, Xu J, Shi Y. A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation. Cell Rep. 2016 Feb 9;14(5):1000-1009. doi: 10.1016/j.celrep.2015.12.091. Epub 2016 Jan 21. PubMed PMID: 26804915; PubMed Central PMCID: PMC4749408.

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Cui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, Campbell A, Harro D, Iwase S, Trievel RC, Rivers A, DeSimone J, Lavelle D, Saunthararajah Y, Engel JD. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015 Jul 16;126(3):386-96. doi: 10.1182/blood-2015-02-626259. Epub 2015 Jun 1. PubMed PMID: 26031919; PubMed Central PMCID: PMC4504950.

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Agarwal S, Macfarlan TS, Sartor MA, Iwase S. Sequencing of first-strand cDNA library reveals full-length transcriptomes. Nat Commun. 2015 Jan 21;6:6002. doi: 10.1038/ncomms7002. PubMed PMID: 25607527; PubMed Central PMCID: PMC5054741.

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Vallianatos CN, Iwase S. Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders. Epigenomics. 2015;7(3):503-19. doi: 10.2217/epi.15.1. Review. PubMed PMID: 26077434; PubMed Central PMCID: PMC4501478.

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Iwase S, Xiang B, Ghosh S, Ren T, Lewis PW, Cochrane JC, Allis CD, Picketts DJ, Patel DJ, Li H, Shi Y. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol. 2011 Jun 12;18(7):769-76. doi: 10.1038/nsmb.2062. PubMed PMID: 21666679; PubMed Central PMCID: PMC3130887.

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Iwase S, Shi Y. Histone and DNA modifications in mental retardation. Prog Drug Res. 2011;67:147-73. doi: 10.1007/978-3-7643-8989-5_8. Review. PubMed PMID: 21141729.

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Rujirabanjerd S, Nelson J, Tarpey PS, Hackett A, Edkins S, Raymond FL, Schwartz CE, Turner G, Iwase S, Shi Y, Futreal PA, Stratton MR, Gecz J. Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation. Eur J Hum Genet. 2010 Mar;18(3):330-5. doi: 10.1038/ejhg.2009.175. Epub 2009 Oct 14. PubMed PMID: 19826449; PubMed Central PMCID: PMC2987212.

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Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007 Oct 11;449(7163):689-94. doi: 10.1038/nature06192. Epub 2007 Sep 12. PubMed PMID: 17851529.

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Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar 23;128(6):1077-88. doi: 10.1016/j.cell.2007.02.017. Epub 2007 Feb 22. PubMed PMID: 17320160.

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Iwase S, Shono N, Honda A, Nakanishi T, Kashiwabara S, Takahashi S, Baba T. A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice. FEBS Lett. 2006 May 29;580(13):3129-35. doi: 10.1016/j.febslet.2006.04.065. Epub 2006 May 3. PubMed PMID: 16684532.

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Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y. Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell. 2005 Sep 16;19(6):857-64. doi: 10.1016/j.molcel.2005.08.027. PubMed PMID: 16140033.

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Kim E, Nishimura H, Iwase S, Yamagata K, Kashiwabara S, Baba T. Synthesis, processing, and subcellular localization of mouse ADAM3 during spermatogenesis and epididymal sperm transport. J Reprod Dev. 2004 Oct;50(5):571-8. doi: 10.1262/jrd.50.571. PubMed PMID: 15514464.

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Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T. Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression. Biochem Biophys Res Commun. 2004 Sep 17;322(2):601-8. doi: 10.1016/j.bbrc.2004.07.163. PubMed PMID: 15325272.

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Sugiura S, Kashiwabara S, Iwase S, Baba T. Expression of a testis-specific form of TBP-related factor 2 (TRF2) mRNA during mouse spermatogenesis. J Reprod Dev. 2003 Feb;49(1):107-11. doi: 10.1262/jrd.49.107. PubMed PMID: 14967955.