Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
  • Page of 1
Porter RS, Nagai M, An S, Gavilan MC, Murata-Nakamura Y, Bonefas KM, Zhou B, Dionne O, Manuel JM, St-Germain J, Browning L, Laurent B, Cho US, Iwase S. A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21A. bioRxiv. 2023 Oct 21;. doi: 10.1101/2023.10.20.563357. PubMed PMID: 37904995; PubMed Central PMCID: PMC10614952.
Tsukahara T, Kethireddy S, Bonefas K, Chen A, Sutton BL, Dou Y, Iwase S, Sutton MA. Division of labor among H3K4 Methyltransferases Defines Distinct Facets of Homeostatic Plasticity. bioRxiv. 2023 Sep 22;. doi: 10.1101/2023.09.20.558734. PubMed PMID: 37790395; PubMed Central PMCID: PMC10542164.
Xie H, Linning-Duffy K, Demireva EY, Toh H, Abolibdeh B, Shi J, Zhou B, Iwase S, Yan L. CRISPR-based Genome Editing of a Diurnal Rodent, Nile Grass Rat ( Arvicanthis niloticus). bioRxiv. 2023 Aug 23;. doi: 10.1101/2023.08.23.553600. PubMed PMID: 37662225; PubMed Central PMCID: PMC10473663.
Rivero-Ríos P, Tsukahara T, Uygun T, Chen A, Chavis GD, Giridharan SSP, Iwase S, Sutton MA, Weisman LS. Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity. J Cell Biol. 2023 Jul 3;222(7). doi: 10.1083/jcb.202207025. Epub 2023 May 4. PubMed PMID: 37141105; PubMed Central PMCID: PMC10165670.
Porter RS, Iwase S. Modulation of chromatin architecture influences the neuronal nucleus through activity-regulated gene expression. Biochem Soc Trans. 2023 Apr 26;51(2):703-713. doi: 10.1042/BST20220889. Review. PubMed PMID: 36929379; PubMed Central PMCID: PMC10959270.
Bonefas KM, Vallianatos CN, Raines B, Tronson NC, Iwase S. Sexually Dimorphic Alterations in the Transcriptome and Behavior with Loss of Histone Demethylase KDM5C. Cells. 2023 Feb 16;12(4). doi: 10.3390/cells12040637. PubMed PMID: 36831303; PubMed Central PMCID: PMC9954040.
Goltseker K, Garay P, Bonefas K, Iwase S, Barak S. Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse. Transl Psychiatry. 2023 Feb 15;13(1):55. doi: 10.1038/s41398-023-02352-2. PubMed PMID: 36792579; PubMed Central PMCID: PMC9932068.
Ekaputri S, Choi EK, Sabelli M, Aring L, Green KJ, Chang J, Bao K, Choi HS, Iwase S, Kim J, Corradini E, Pietrangelo A, Burke MD, Seo YA. A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2121400119. doi: 10.1073/pnas.2121400119. Epub 2022 Jun 22. PubMed PMID: 35737834; PubMed Central PMCID: PMC9245668.
Samanta MK, Gayen S, Harris C, Maclary E, Murata-Nakamura Y, Malcore RM, Porter RS, Garay PM, Vallianatos CN, Samollow PB, Iwase S, Kalantry S. Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. Nat Commun. 2022 May 11;13(1):2602. doi: 10.1038/s41467-022-30352-1. PubMed PMID: 35545632; PubMed Central PMCID: PMC9095838.
Bonefas KM, Iwase S. Soma-to-germline transformation in chromatin-linked neurodevelopmental disorders?. FEBS J. 2022 Apr;289(8):2301-2317. doi: 10.1111/febs.16196. Epub 2021 Oct 8. Review. PubMed PMID: 34514717; PubMed Central PMCID: PMC8918023.
Aring L, Choi EK, Kopera H, Lanigan T, Iwase S, Klionsky DJ, Seo YA. A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation. J Neurochem. 2022 Feb;160(3):356-375. doi: 10.1111/jnc.15548. Epub 2021 Dec 8. PubMed PMID: 34837396; PubMed Central PMCID: PMC8811950.
Agarwal S, Bonefas KM, Garay PM, Brookes E, Murata-Nakamura Y, Porter RS, Macfarlan TS, Ren B, Iwase S. KDM1A maintains genome-wide homeostasis of transcriptional enhancers. Genome Res. 2021 Feb;31(2):186-197. doi: 10.1101/gr.234559.118. Epub 2021 Jan 7. PubMed PMID: 33414108; PubMed Central PMCID: PMC7849409.
Seo YA, Choi EK, Aring L, Paschall M, Iwase S. Transcriptome Analysis of the Cerebellum of Mice Fed a Manganese-Deficient Diet. Front Genet. 2020;11:558725. doi: 10.3389/fgene.2020.558725. eCollection 2020. PubMed PMID: 33408735; PubMed Central PMCID: PMC7780674.
Garay PM, Chen A, Tsukahara T, Rodríguez Díaz JC, Kohen R, Althaus JC, Wallner MA, Giger RJ, Jones KS, Sutton MA, Iwase S. RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling. Cell Rep. 2020 Aug 11;32(6):108002. doi: 10.1016/j.celrep.2020.108002. PubMed PMID: 32783930; PubMed Central PMCID: PMC7418709.
Vallianatos CN, Raines B, Porter RS, Bonefas KM, Wu MC, Garay PM, Collette KM, Seo YA, Dou Y, Keegan CE, Tronson NC, Iwase S. Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation. Commun Biol. 2020 Jun 1;3(1):278. doi: 10.1038/s42003-020-1001-6. PubMed PMID: 32483278; PubMed Central PMCID: PMC7264178.
Choi EK, Aring L, Das NK, Solanki S, Inohara N, Iwase S, Samuelson LC, Shah YM, Seo YA. Impact of dietary manganese on experimental colitis in mice. FASEB J. 2020 Feb;34(2):2929-2943. doi: 10.1096/fj.201902396R. Epub 2019 Dec 29. PubMed PMID: 31908045; PubMed Central PMCID: PMC8103308.
Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT. Identification of lysine methylation in the core GTPase domain by GoMADScan. PLoS One. 2019;14(8):e0219436. doi: 10.1371/journal.pone.0219436. eCollection 2019. PubMed PMID: 31390367; PubMed Central PMCID: PMC6685615.
Choi EK, Nguyen TT, Iwase S, Seo YA. Ferroportin disease mutations influence manganese accumulation and cytotoxicity. FASEB J. 2019 Feb;33(2):2228-2240. doi: 10.1096/fj.201800831R. Epub 2018 Sep 24. PubMed PMID: 30247984; PubMed Central PMCID: PMC6338638.
Vallianatos CN, Farrehi C, Friez MJ, Burmeister M, Keegan CE, Iwase S. Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability. Front Mol Neurosci. 2018;11:104. doi: 10.3389/fnmol.2018.00104. eCollection 2018. PubMed PMID: 29670509; PubMed Central PMCID: PMC5893713.
Iwase S, Martin DM. Chromatin in nervous system development and disease. Mol Cell Neurosci. 2018 Mar;87:1-3. doi: 10.1016/j.mcn.2017.12.006. Epub 2017 Dec 15. PubMed PMID: 29248671; PubMed Central PMCID: PMC6591722.
Porter RS, Jaamour F, Iwase S. Neuron-specific alternative splicing of transcriptional machineries: Implications for neurodevelopmental disorders. Mol Cell Neurosci. 2018 Mar;87:35-45. doi: 10.1016/j.mcn.2017.10.006. Epub 2017 Dec 15. Review. PubMed PMID: 29254826; PubMed Central PMCID: PMC5828955.
Yao H, Hill SF, Skidmore JM, Sperry ED, Swiderski DL, Sanchez GJ, Bartels CF, Raphael Y, Scacheri PC, Iwase S, Martin DM. CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development. JCI Insight. 2018 Feb 22;3(4). doi: 10.1172/jci.insight.97440. eCollection 2018 Feb 22. PubMed PMID: 29467333; PubMed Central PMCID: PMC5916250.
Choi EK, Nguyen TT, Gupta N, Iwase S, Seo YA. Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders. Sci Rep. 2018 Feb 16;8(1):3163. doi: 10.1038/s41598-018-21464-0. PubMed PMID: 29453449; PubMed Central PMCID: PMC5816659.
Porter RS, Murata-Nakamura Y, Nagasu H, Kim HG, Iwase S. Transcriptome Analysis Revealed Impaired cAMP Responsiveness in PHF21A-Deficient Human Cells. Neuroscience. 2018 Feb 1;370:170-180. doi: 10.1016/j.neuroscience.2017.05.031. Epub 2017 May 29. PubMed PMID: 28571721; PubMed Central PMCID: PMC5708152.
Iwase S, Bérubé NG, Zhou Z, Kasri NN, Battaglioli E, Scandaglia M, Barco A. Epigenetic Etiology of Intellectual Disability. J Neurosci. 2017 Nov 8;37(45):10773-10782. doi: 10.1523/JNEUROSCI.1840-17.2017. Review. PubMed PMID: 29118205; PubMed Central PMCID: PMC5678009.
Scandaglia M, Lopez-Atalaya JP, Medrano-Fernandez A, Lopez-Cascales MT, Del Blanco B, Lipinski M, Benito E, Olivares R, Iwase S, Shi Y, Barco A. Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons. Cell Rep. 2017 Oct 3;21(1):47-59. doi: 10.1016/j.celrep.2017.09.014. PubMed PMID: 28978483; PubMed Central PMCID: PMC5679733.
Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T, Kashihara N. Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice. Sci Rep. 2017 Aug 18;7(1):8801. doi: 10.1038/s41598-017-08054-2. PubMed PMID: 28821730; PubMed Central PMCID: PMC5562821.
Garay PM, Wallner MA, Iwase S. Yin-yang actions of histone methylation regulatory complexes in the brain. Epigenomics. 2016 Dec;8(12):1689-1708. doi: 10.2217/epi-2016-0090. Epub 2016 Nov 18. Review. PubMed PMID: 27855486; PubMed Central PMCID: PMC5289040.
Wei G, Deng X, Agarwal S, Iwase S, Disteche C, Xu J. Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells. J Mol Neurosci. 2016 Sep;60(1):33-45. doi: 10.1007/s12031-016-0770-3. Epub 2016 Jul 16. PubMed PMID: 27421841; PubMed Central PMCID: PMC5412133.
Labonne JD, Lee KH, Iwase S, Kong IK, Diamond MP, Layman LC, Kim CH, Kim HG. An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability. Hum Genet. 2016 Jul;135(7):757-71. doi: 10.1007/s00439-016-1668-4. Epub 2016 Apr 22. PubMed PMID: 27106595.
Iwase S, Brookes E, Agarwal S, Badeaux AI, Ito H, Vallianatos CN, Tomassy GS, Kasza T, Lin G, Thompson A, Gu L, Kwan KY, Chen C, Sartor MA, Egan B, Xu J, Shi Y. A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation. Cell Rep. 2016 Feb 9;14(5):1000-1009. doi: 10.1016/j.celrep.2015.12.091. Epub 2016 Jan 21. PubMed PMID: 26804915; PubMed Central PMCID: PMC4749408.
Cui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, Campbell A, Harro D, Iwase S, Trievel RC, Rivers A, DeSimone J, Lavelle D, Saunthararajah Y, Engel JD. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015 Jul 16;126(3):386-96. doi: 10.1182/blood-2015-02-626259. Epub 2015 Jun 1. PubMed PMID: 26031919; PubMed Central PMCID: PMC4504950.
Agarwal S, Macfarlan TS, Sartor MA, Iwase S. Sequencing of first-strand cDNA library reveals full-length transcriptomes. Nat Commun. 2015 Jan 21;6:6002. doi: 10.1038/ncomms7002. PubMed PMID: 25607527; PubMed Central PMCID: PMC5054741.
Vallianatos CN, Iwase S. Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders. Epigenomics. 2015;7(3):503-19. doi: 10.2217/epi.15.1. Review. PubMed PMID: 26077434; PubMed Central PMCID: PMC4501478.
Iwase S, Xiang B, Ghosh S, Ren T, Lewis PW, Cochrane JC, Allis CD, Picketts DJ, Patel DJ, Li H, Shi Y. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol. 2011 Jun 12;18(7):769-76. doi: 10.1038/nsmb.2062. PubMed PMID: 21666679; PubMed Central PMCID: PMC3130887.
Iwase S, Shi Y. Histone and DNA modifications in mental retardation. Prog Drug Res. 2011;67:147-73. doi: 10.1007/978-3-7643-8989-5_8. Review. PubMed PMID: 21141729.
Rujirabanjerd S, Nelson J, Tarpey PS, Hackett A, Edkins S, Raymond FL, Schwartz CE, Turner G, Iwase S, Shi Y, Futreal PA, Stratton MR, Gecz J. Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation. Eur J Hum Genet. 2010 Mar;18(3):330-5. doi: 10.1038/ejhg.2009.175. Epub 2009 Oct 14. PubMed PMID: 19826449; PubMed Central PMCID: PMC2987212.
Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007 Oct 11;449(7163):689-94. doi: 10.1038/nature06192. Epub 2007 Sep 12. PubMed PMID: 17851529.
Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar 23;128(6):1077-88. doi: 10.1016/j.cell.2007.02.017. Epub 2007 Feb 22. PubMed PMID: 17320160.
Iwase S, Shono N, Honda A, Nakanishi T, Kashiwabara S, Takahashi S, Baba T. A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice. FEBS Lett. 2006 May 29;580(13):3129-35. doi: 10.1016/j.febslet.2006.04.065. Epub 2006 May 3. PubMed PMID: 16684532.
Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y. Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell. 2005 Sep 16;19(6):857-64. doi: 10.1016/j.molcel.2005.08.027. PubMed PMID: 16140033.
Kim E, Nishimura H, Iwase S, Yamagata K, Kashiwabara S, Baba T. Synthesis, processing, and subcellular localization of mouse ADAM3 during spermatogenesis and epididymal sperm transport. J Reprod Dev. 2004 Oct;50(5):571-8. doi: 10.1262/jrd.50.571. PubMed PMID: 15514464.
Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T. Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression. Biochem Biophys Res Commun. 2004 Sep 17;322(2):601-8. doi: 10.1016/j.bbrc.2004.07.163. PubMed PMID: 15325272.
Sugiura S, Kashiwabara S, Iwase S, Baba T. Expression of a testis-specific form of TBP-related factor 2 (TRF2) mRNA during mouse spermatogenesis. J Reprod Dev. 2003 Feb;49(1):107-11. doi: 10.1262/jrd.49.107. PubMed PMID: 14967955.
An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability. Human genetics. . NIHMSID: NIHMS944291.
KDM1A maintains genome-wide homeostasis of transcriptional enhancers. Genome research. . NIHMSID: NIHMS1664700.
Modulation of chromatin architecture influences the neuronal nucleus through activity-regulated gene expression. Biochemical Society transactions. . NIHMSID: NIHMS1972643.
Modulation of chromatin architecture influences the neuronal nucleus through activity-regulated gene expression. Biochemical Society transactions. . NIHMSID: NIHMS1972644.
What would you like to do?
  • Page of 1