Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex.
Cell Rep.
2025 Jan 28;44(1):115213. doi: 10.1016/j.celrep.2024.115213. Epub 2025 Jan 15. PubMed PMID:
39817906; PubMed Central PMCID:
PMC11864812.
KDM5C is a sex-biased brake against germline gene expression programs in somatic lineages.
bioRxiv.
2024 Nov 8;. doi: 10.1101/2024.11.08.622665. PubMed PMID:
39574581; PubMed Central PMCID:
PMC11581037.
Neuronal splicing of the unmethylated histone H3K4 reader, PHF21A, prevents excessive synaptogenesis.
J Biol Chem.
2024 Nov;300(11):107881. doi: 10.1016/j.jbc.2024.107881. Epub 2024 Oct 11. PubMed PMID:
39395799; PubMed Central PMCID:
PMC11605454.
Regulation of Sex-biased Gene Expression by the Ancestral X-Y Chromosomal Gene Pair Kdm5c-Kdm5d.
bioRxiv.
2024 Oct 27;. doi: 10.1101/2024.10.24.620066. PubMed PMID:
39484414; PubMed Central PMCID:
PMC11527134.
A neuron-specific microexon ablates the novel DNA-binding function of a histone H3K4me0 reader PHF21A.
bioRxiv.
2023 Oct 21;. doi: 10.1101/2023.10.20.563357. PubMed PMID:
37904995; PubMed Central PMCID:
PMC10614952.
Division of labor among H3K4 Methyltransferases Defines Distinct Facets of Homeostatic Plasticity.
bioRxiv.
2023 Sep 22;. doi: 10.1101/2023.09.20.558734. PubMed PMID:
37790395; PubMed Central PMCID:
PMC10542164.
CRISPR-based Genome Editing of a Diurnal Rodent, Nile Grass Rat ( Arvicanthis niloticus).
bioRxiv.
2023 Aug 23;. doi: 10.1101/2023.08.23.553600. PubMed PMID:
37662225; PubMed Central PMCID:
PMC10473663.
S-Cone Photoreceptors Regulate Daily Rhythms and Light-Induced Arousal/Wakefulness in Diurnal Grass Rats (Arvicanthis niloticus).
J Biol Rhythms.
2023 Aug;38(4):366-378. doi: 10.1177/07487304231170068. Epub 2023 May 24. PubMed PMID:
37222434; PubMed Central PMCID:
PMC10364626.
Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity.
J Cell Biol.
2023 Jul 3;222(7). doi: 10.1083/jcb.202207025. Epub 2023 May 4. PubMed PMID:
37141105; PubMed Central PMCID:
PMC10165670.
Effects of light therapy on sleep/wakefulness, daily rhythms, and the central orexin system in a diurnal rodent model of seasonal affective disorder.
J Affect Disord.
2023 Jul 1;332:299-308. doi: 10.1016/j.jad.2023.04.012. Epub 2023 Apr 13. PubMed PMID:
37060954; PubMed Central PMCID:
PMC10161688.
Modulation of chromatin architecture influences the neuronal nucleus through activity-regulated gene expression.
Biochem Soc Trans.
2023 Apr 26;51(2):703-713. doi: 10.1042/BST20220889. Review. PubMed PMID:
36929379; PubMed Central PMCID:
PMC10959270.
Daytime Light Deficiency Leads to Sex- and Brain Region-Specific Neuroinflammatory Responses in a Diurnal Rodent.
Cell Mol Neurobiol.
2023 Apr;43(3):1369-1384. doi: 10.1007/s10571-022-01256-x. Epub 2022 Jul 21. PubMed PMID:
35864429; PubMed Central PMCID:
PMC10635710.
Sexually Dimorphic Alterations in the Transcriptome and Behavior with Loss of Histone Demethylase KDM5C.
Cells.
2023 Feb 16;12(4). doi: 10.3390/cells12040637. PubMed PMID:
36831303; PubMed Central PMCID:
PMC9954040.
Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse.
Transl Psychiatry.
2023 Feb 15;13(1):55. doi: 10.1038/s41398-023-02352-2. PubMed PMID:
36792579; PubMed Central PMCID:
PMC9932068.
Effects of bright light therapy on neuroinflammatory and neuroplasticity markers in a diurnal rodent model of Seasonal Affective Disorder.
Ann Med.
2023;55(2):2249015. doi: 10.1080/07853890.2023.2249015. PubMed PMID:
37625385; PubMed Central PMCID:
PMC10461522.
A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages.
Proc Natl Acad Sci U S A.
2022 Jun 28;119(26):e2121400119. doi: 10.1073/pnas.2121400119. Epub 2022 Jun 22. PubMed PMID:
35737834; PubMed Central PMCID:
PMC9245668.
Activation of Xist by an evolutionarily conserved function of KDM5C demethylase.
Nat Commun.
2022 May 11;13(1):2602. doi: 10.1038/s41467-022-30352-1. PubMed PMID:
35545632; PubMed Central PMCID:
PMC9095838.
Soma-to-germline transformation in chromatin-linked neurodevelopmental disorders?.
FEBS J.
2022 Apr;289(8):2301-2317. doi: 10.1111/febs.16196. Epub 2021 Oct 8. Review. PubMed PMID:
34514717; PubMed Central PMCID:
PMC8918023.
A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation.
J Neurochem.
2022 Feb;160(3):356-375. doi: 10.1111/jnc.15548. Epub 2021 Dec 8. PubMed PMID:
34837396; PubMed Central PMCID:
PMC8811950.
KDM1A maintains genome-wide homeostasis of transcriptional enhancers.
Genome Res.
2021 Feb;31(2):186-197. doi: 10.1101/gr.234559.118. Epub 2021 Jan 7. PubMed PMID:
33414108; PubMed Central PMCID:
PMC7849409.
Transcriptome Analysis of the Cerebellum of Mice Fed a Manganese-Deficient Diet.
Front Genet.
2020;11:558725. doi: 10.3389/fgene.2020.558725. eCollection 2020. PubMed PMID:
33408735; PubMed Central PMCID:
PMC7780674.
RAI1 Regulates Activity-Dependent Nascent Transcription and Synaptic Scaling.
Cell Rep.
2020 Aug 11;32(6):108002. doi: 10.1016/j.celrep.2020.108002. PubMed PMID:
32783930; PubMed Central PMCID:
PMC7418709.
Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation.
Commun Biol.
2020 Jun 1;3(1):278. doi: 10.1038/s42003-020-1001-6. PubMed PMID:
32483278; PubMed Central PMCID:
PMC7264178.
Impact of dietary manganese on experimental colitis in mice.
FASEB J.
2020 Feb;34(2):2929-2943. doi: 10.1096/fj.201902396R. Epub 2019 Dec 29. PubMed PMID:
31908045; PubMed Central PMCID:
PMC8103308.
Identification of lysine methylation in the core GTPase domain by GoMADScan.
PLoS One.
2019;14(8):e0219436. doi: 10.1371/journal.pone.0219436. eCollection 2019. PubMed PMID:
31390367; PubMed Central PMCID:
PMC6685615.
Ferroportin disease mutations influence manganese accumulation and cytotoxicity.
FASEB J.
2019 Feb;33(2):2228-2240. doi: 10.1096/fj.201800831R. Epub 2018 Sep 24. PubMed PMID:
30247984; PubMed Central PMCID:
PMC6338638.
Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability.
Front Mol Neurosci.
2018;11:104. doi: 10.3389/fnmol.2018.00104. eCollection 2018. PubMed PMID:
29670509; PubMed Central PMCID:
PMC5893713.
Chromatin in nervous system development and disease.
Mol Cell Neurosci.
2018 Mar;87:1-3. doi: 10.1016/j.mcn.2017.12.006. Epub 2017 Dec 15. PubMed PMID:
29248671; PubMed Central PMCID:
PMC6591722.
Neuron-specific alternative splicing of transcriptional machineries: Implications for neurodevelopmental disorders.
Mol Cell Neurosci.
2018 Mar;87:35-45. doi: 10.1016/j.mcn.2017.10.006. Epub 2017 Dec 15. Review. PubMed PMID:
29254826; PubMed Central PMCID:
PMC5828955.
CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development.
JCI Insight.
2018 Feb 22;3(4). doi: 10.1172/jci.insight.97440. eCollection 2018 Feb 22. PubMed PMID:
29467333; PubMed Central PMCID:
PMC5916250.
Functional analysis of SLC39A8 mutations and their implications for manganese deficiency and mitochondrial disorders.
Sci Rep.
2018 Feb 16;8(1):3163. doi: 10.1038/s41598-018-21464-0. PubMed PMID:
29453449; PubMed Central PMCID:
PMC5816659.
Transcriptome Analysis Revealed Impaired cAMP Responsiveness in PHF21A-Deficient Human Cells.
Neuroscience.
2018 Feb 1;370:170-180. doi: 10.1016/j.neuroscience.2017.05.031. Epub 2017 May 29. PubMed PMID:
28571721; PubMed Central PMCID:
PMC5708152.
Epigenetic Etiology of Intellectual Disability.
J Neurosci.
2017 Nov 8;37(45):10773-10782. doi: 10.1523/JNEUROSCI.1840-17.2017. Review. PubMed PMID:
29118205; PubMed Central PMCID:
PMC5678009.
Loss of Kdm5c Causes Spurious Transcription and Prevents the Fine-Tuning of Activity-Regulated Enhancers in Neurons.
Cell Rep.
2017 Oct 3;21(1):47-59. doi: 10.1016/j.celrep.2017.09.014. PubMed PMID:
28978483; PubMed Central PMCID:
PMC5679733.
Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice.
Sci Rep.
2017 Aug 18;7(1):8801. doi: 10.1038/s41598-017-08054-2. PubMed PMID:
28821730; PubMed Central PMCID:
PMC5562821.
Yin-yang actions of histone methylation regulatory complexes in the brain.
Epigenomics.
2016 Dec;8(12):1689-1708. doi: 10.2217/epi-2016-0090. Epub 2016 Nov 18. Review. PubMed PMID:
27855486; PubMed Central PMCID:
PMC5289040.
Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells.
J Mol Neurosci.
2016 Sep;60(1):33-45. doi: 10.1007/s12031-016-0770-3. Epub 2016 Jul 16. PubMed PMID:
27421841; PubMed Central PMCID:
PMC5412133.
An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability.
Hum Genet.
2016 Jul;135(7):757-71. doi: 10.1007/s00439-016-1668-4. Epub 2016 Apr 22. PubMed PMID:
27106595.
A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.
Cell Rep.
2016 Feb 9;14(5):1000-1009. doi: 10.1016/j.celrep.2015.12.091. Epub 2016 Jan 21. PubMed PMID:
26804915; PubMed Central PMCID:
PMC4749408.
The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.
Blood.
2015 Jul 16;126(3):386-96. doi: 10.1182/blood-2015-02-626259. Epub 2015 Jun 1. PubMed PMID:
26031919; PubMed Central PMCID:
PMC4504950.
Sequencing of first-strand cDNA library reveals full-length transcriptomes.
Nat Commun.
2015 Jan 21;6:6002. doi: 10.1038/ncomms7002. PubMed PMID:
25607527; PubMed Central PMCID:
PMC5054741.
Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.
Epigenomics.
2015;7(3):503-19. doi: 10.2217/epi.15.1. Review. PubMed PMID:
26077434; PubMed Central PMCID:
PMC4501478.
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome.
Nat Struct Mol Biol.
2011 Jun 12;18(7):769-76. doi: 10.1038/nsmb.2062. PubMed PMID:
21666679; PubMed Central PMCID:
PMC3130887.
Histone and DNA modifications in mental retardation.
Prog Drug Res.
2011;67:147-73. doi: 10.1007/978-3-7643-8989-5_8. Review. PubMed PMID:
21141729.
Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation.
Eur J Hum Genet.
2010 Mar;18(3):330-5. doi: 10.1038/ejhg.2009.175. Epub 2009 Oct 14. PubMed PMID:
19826449; PubMed Central PMCID:
PMC2987212.
A histone H3 lysine 27 demethylase regulates animal posterior development.
Nature.
2007 Oct 11;449(7163):689-94. doi: 10.1038/nature06192. Epub 2007 Sep 12. PubMed PMID:
17851529.
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.
Cell.
2007 Mar 23;128(6):1077-88. doi: 10.1016/j.cell.2007.02.017. Epub 2007 Feb 22. PubMed PMID:
17320160.
A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice.
FEBS Lett.
2006 May 29;580(13):3129-35. doi: 10.1016/j.febslet.2006.04.065. Epub 2006 May 3. PubMed PMID:
16684532.
Regulation of LSD1 histone demethylase activity by its associated factors.
Mol Cell.
2005 Sep 16;19(6):857-64. doi: 10.1016/j.molcel.2005.08.027. PubMed PMID:
16140033.
Synthesis, processing, and subcellular localization of mouse ADAM3 during spermatogenesis and epididymal sperm transport.
J Reprod Dev.
2004 Oct;50(5):571-8. doi: 10.1262/jrd.50.571. PubMed PMID:
15514464.
What would you like to do?