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Yang H, Kundra S, Chojnacki M, Liu K, Fuse MA, Abouelhassan Y, Kallifidas D, Zhang P, Huang G, Jin S, Ding Y, Luesch H, Rohde KH, Dunman PM, Lemos JA, Huigens RW 3rd. A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents. J Med Chem. 2021 Apr 21;. doi: 10.1021/acs.jmedchem.1c00168. [Epub ahead of print] PubMed PMID: 33881312; NIHMSID:NIHMS1697056.
Hou YJ, Chiba S, Halfmann P, Ehre C, Kuroda M, Dinnon KH 3rd, Leist SR, Schäfer A, Nakajima N, Takahashi K, Lee RE, Mascenik TM, Graham R, Edwards CE, Tse LV, Okuda K, Markmann AJ, Bartelt L, de Silva A, Margolis DM, Boucher RC, Randell SH, Suzuki T, Gralinski LE, Kawaoka Y, Baric RS. SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science. 2020 Dec 18;370(6523):1464-1468. doi: 10.1126/science.abe8499. Epub 2020 Nov 12. PubMed PMID: 33184236; PubMed Central PMCID: PMC7775736.
Kajfasz JK, Katrak C, Ganguly T, Vargas J, Wright L, Peters ZT, Spatafora GA, Abranches J, Lemos JA. Manganese Uptake, Mediated by SloABC and MntH, Is Essential for the Fitness of Streptococcus mutans. mSphere. 2020 Jan 8;5(1). doi: 10.1128/mSphere.00764-19. PubMed PMID: 31915219; PubMed Central PMCID: PMC6952196.
Rody WJ Jr, Chamberlain CA, Emory-Carter AK, McHugh KP, Wallet SM, Spicer V, Krokhin O, Holliday LS. The proteome of extracellular vesicles released by clastic cells differs based on their substrate. PLoS One. 2019;14(7):e0219602. doi: 10.1371/journal.pone.0219602. eCollection 2019. PubMed PMID: 31291376; PubMed Central PMCID: PMC6619814.
Culp DJ, Stewart C, Wallet SM. Oral epithelial membrane-associated mucins and transcriptional changes with Sjögren's syndrome. Oral Dis. 2019 Jul;25(5):1325-1334. doi: 10.1111/odi.13098. Epub 2019 Apr 12. PubMed PMID: 30920100.
Rody WJ Jr, Truzman EL, Foster DT, Smith LN, Rocha FG, Sorenson HL, Wallet SM, Holliday LS. Clastic cells in orthodontic treatment: Translational challenges and recent advances. Orthod Craniofac Res. 2019 May;22 Suppl 1:180-185. doi: 10.1111/ocr.12285. PubMed PMID: 31074132.
Gerber MH, Underwood PW, Judge SM, Delitto D, Delitto AE, Nosacka RL, DiVita BB, Thomas RM, Permuth JB, Hughes SJ, Wallet SM, Judge AR, Trevino JG. Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine. Int J Mol Sci. 2018 Dec 1;19(12). doi: 10.3390/ijms19123836. PubMed PMID: 30513792; PubMed Central PMCID: PMC6321633.
Wallet SM, Puri V, Gibson FC. Linkage of Infection to Adverse Systemic Complications: Periodontal Disease, Toll-Like Receptors, and Other Pattern Recognition Systems. Vaccines (Basel). 2018 Apr 5;6(2). doi: 10.3390/vaccines6020021. Review. PubMed PMID: 29621153; PubMed Central PMCID: PMC6027258.
Williams JC, Zhang X, Karki M, Chi YY, Wallet SM, Rudy BJ, Nichols SL, Goodenow MM, Sleasman JW. Soluble CD14, CD163, and CD27 biomarkers distinguish ART-suppressed youth living with HIV from healthy controls. J Leukoc Biol. 2018 Apr;103(4):671-680. doi: 10.1002/JLB.3A0717-294RR. Epub 2018 Jan 29. PubMed PMID: 29377283; PubMed Central PMCID: PMC6528780.
Delitto AE, Rocha F, Decker AM, Amador B, Sorenson HL, Wallet SM. MyD88-mediated innate sensing by oral epithelial cells controls periodontal inflammation. Arch Oral Biol. 2018 Mar;87:125-130. doi: 10.1016/j.archoralbio.2017.12.016. Epub 2017 Dec 16. PubMed PMID: 29289808; PubMed Central PMCID: PMC5816687.
Grau KR, Roth AN, Zhu S, Hernandez A, Colliou N, DiVita BB, Philip DT, Riffe C, Giasson B, Wallet SM, Mohamadzadeh M, Karst SM. The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue. Nat Microbiol. 2017 Dec;2(12):1586-1591. doi: 10.1038/s41564-017-0057-7. Epub 2017 Nov 6. PubMed PMID: 29109476; PubMed Central PMCID: PMC5705318.
Li J, Doty AL, Tang Y, Berrie D, Iqbal A, Tan SA, Clare-Salzler MJ, Wallet SM, Glover SC. Enrichment of IL-17A+ IFN-γ+ and IL-22+ IFN-γ+ T cell subsets is associated with reduction of NKp44+ ILC3s in the terminal ileum of Crohn's disease patients. Clin Exp Immunol. 2017 Oct;190(1):143-153. doi: 10.1111/cei.12996. Epub 2017 Jul 7. PubMed PMID: 28586085; PubMed Central PMCID: PMC5588779.
Shaddox LM, Mullersman AF, Huang H, Wallet SM, Langaee T, Aukhil I. Epigenetic regulation of inflammation in localized aggressive periodontitis. Clin Epigenetics. 2017;9:94. doi: 10.1186/s13148-017-0385-8. eCollection 2017. PubMed PMID: 28883894; PubMed Central PMCID: PMC5581417.
Riley JL 3rd, Cruz-Almeida Y, Dasilva Ribeiro MC, Simon CB, Eckert NR, Aguirre M, Sorenson HL, Tighe PJ, Edwards RR, Wallet SM. Age Differences in the Time Course and Magnitude of Changes in Circulating Neuropeptides After Pain Evocation in Humans. J Pain. 2017 Sep;18(9):1078-1086. doi: 10.1016/j.jpain.2017.04.006. Epub 2017 Apr 29. PubMed PMID: 28461253; PubMed Central PMCID: PMC5581306.
Branco-de-Almeida LS, Cruz-Almeida Y, Gonzalez-Marrero Y, Huang H, Aukhil I, Harrison P, Wallet SM, Shaddox LM. Local and Plasma Biomarker Profiles in Localized Aggressive Periodontitis. JDR Clin Trans Res. 2017 Jul;2(3):258-268. doi: 10.1177/2380084417701898. Epub 2017 Apr 14. PubMed PMID: 28879248; PubMed Central PMCID: PMC5576058.
Velsko IM, Cruz-Almeida Y, Huang H, Wallet SM, Shaddox LM. Cytokine response patterns to complex biofilms by mononuclear cells discriminate patient disease status and biofilm dysbiosis. J Oral Microbiol. 2017;9(1):1330645. doi: 10.1080/20002297.2017.1330645. eCollection 2017. PubMed PMID: 28748035; PubMed Central PMCID: PMC5508357.
Rody WJ Jr, Krokhin O, Spicer V, Chamberlain CA, Chamberlain M, McHugh KP, Wallet SM, Emory AK, Crull JD, Holliday LS. The use of cell culture platforms to identify novel markers of bone and dentin resorption. Orthod Craniofac Res. 2017 Jun;20 Suppl 1:89-94. doi: 10.1111/ocr.12162. PubMed PMID: 28643914.
Ribeiro-Dasilva MC, Fillingim RB, Wallet SM. Estrogen-Induced Monocytic Response Correlates with TMD Pain: A Case Control Study. J Dent Res. 2017 Mar;96(3):285-291. doi: 10.1177/0022034516678599. Epub 2016 Nov 19. PubMed PMID: 27856968; PubMed Central PMCID: PMC5298393.
Delitto D, Delitto AE, DiVita BB, Pham K, Han S, Hartlage ER, Newby BN, Gerber MH, Behrns KE, Moldawer LL, Thomas RM, George TJ Jr, Brusko TM, Mathews CE, Liu C, Trevino JG, Hughes SJ, Wallet SM. Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment. Cancer Res. 2017 Feb 1;77(3):672-683. doi: 10.1158/0008-5472.CAN-16-1765. Epub 2016 Nov 18. PubMed PMID: 27864347; PubMed Central PMCID: PMC5290036.
Graves CL, Li J, LaPato M, Shapiro MR, Glover SC, Wallet MA, Wallet SM. Intestinal Epithelial Cell Regulation of Adaptive Immune Dysfunction in Human Type 1 Diabetes. Front Immunol. 2016;7:679. doi: 10.3389/fimmu.2016.00679. eCollection 2016. PubMed PMID: 28119693; PubMed Central PMCID: PMC5222791.
Delitto D, Judge SM, Delitto AE, Nosacka RL, Rocha FG, DiVita BB, Gerber MH, George TJ Jr, Behrns KE, Hughes SJ, Wallet SM, Judge AR, Trevino JG. Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia. Oncotarget. 2017 Jan 3;8(1):1177-1189. doi: 10.18632/oncotarget.13593. PubMed PMID: 27901481; PubMed Central PMCID: PMC5352045.
Delitto D, Wallet SM, Hughes SJ. Targeting tumor tolerance: A new hope for pancreatic cancer therapy?. Pharmacol Ther. 2016 Oct;166:9-29. doi: 10.1016/j.pharmthera.2016.06.008. Epub 2016 Jun 22. Review. PubMed PMID: 27343757; NIHMSID:NIHMS800911.
Ebersole JL, Graves CL, Gonzalez OA, Dawson D 3rd, Morford LA, Huja PE, Hartsfield JK Jr, Huja SS, Pandruvada S, Wallet SM. Aging, inflammation, immunity and periodontal disease. Periodontol 2000. 2016 Oct;72(1):54-75. doi: 10.1111/prd.12135. Review. PubMed PMID: 27501491.
Mesia R, Gholami F, Huang H, Clare-Salzler M, Aukhil I, Wallet SM, Shaddox LM. Systemic inflammatory responses in patients with type 2 diabetes with chronic periodontitis. BMJ Open Diabetes Res Care. 2016;4(1):e000260. doi: 10.1136/bmjdrc-2016-000260. eCollection 2016. PubMed PMID: 27651910; PubMed Central PMCID: PMC5020743.
Shaddox LM, Spencer WP, Velsko IM, Al-Kassab H, Huang H, Calderon N, Aukhil I, Wallet SM. Localized aggressive periodontitis immune response to healthy and diseased subgingival plaque. J Clin Periodontol. 2016 Sep;43(9):746-53. doi: 10.1111/jcpe.12560. Epub 2016 Jul 15. PubMed PMID: 27037664; PubMed Central PMCID: PMC4975966.
Pham K, Delitto D, Knowlton AE, Hartlage ER, Madhavan R, Gonzalo DH, Thomas RM, Behrns KE, George TJ Jr, Hughes SJ, Wallet SM, Liu C, Trevino JG. Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture. Am J Pathol. 2016 Jun;186(6):1537-46. doi: 10.1016/j.ajpath.2016.02.009. Epub 2016 Apr 18. PubMed PMID: 27102771; PubMed Central PMCID: PMC4901138.
Allin N, Cruz-Almeida Y, Velsko I, Vovk A, Hovemcamp N, Harrison P, Huang H, Aukhil I, Wallet SM, Shaddox LM. Inflammatory Response Influences Treatment of Localized Aggressive Periodontitis. J Dent Res. 2016 Jun;95(6):635-41. doi: 10.1177/0022034516631973. Epub 2016 Feb 25. PubMed PMID: 26917438; PubMed Central PMCID: PMC4924542.
Delitto D, Zhang D, Han S, Black BS, Knowlton AE, Vlada AC, Sarosi GA, Behrns KE, Thomas RM, Lu X, Liu C, George TJ, Hughes SJ, Wallet SM, Trevino JG. Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment. Clin Cancer Res. 2016 Apr 1;22(7):1787-99. doi: 10.1158/1078-0432.CCR-15-1256. Epub 2015 Dec 14. PubMed PMID: 26667487; PubMed Central PMCID: PMC4818664.
Rody WJ Jr, Wijegunasinghe M, Holliday LS, McHugh KP, Wallet SM. Immunoassay analysis of proteins in gingival crevicular fluid samples from resorbing teeth. Angle Orthod. 2016 Mar;86(2):187-92. doi: 10.2319/032415-195.1. Epub 2015 Jul 8. PubMed PMID: 26154939.
Jones MK, Grau KR, Costantini V, Kolawole AO, de Graaf M, Freiden P, Graves CL, Koopmans M, Wallet SM, Tibbetts SA, Schultz-Cherry S, Wobus CE, Vinjé J, Karst SM. Human norovirus culture in B cells. Nat Protoc. 2015 Dec;10(12):1939-47. doi: 10.1038/nprot.2015.121. Epub 2015 Oct 29. PubMed PMID: 26513671; PubMed Central PMCID: PMC4689599.
Delitto D, Perez C, Han S, Gonzalo DH, Pham K, Knowlton AE, Graves CL, Behrns KE, Moldawer LL, Thomas RM, Liu C, George TJ Jr, Trevino JG, Wallet SM, Hughes SJ. Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer. Cancer Immunol Immunother. 2015 Dec;64(12):1553-63. doi: 10.1007/s00262-015-1760-y. Epub 2015 Sep 30. PubMed PMID: 26423423; PubMed Central PMCID: PMC5129167.
Cruz-Almeida Y, Aguirre M, Sorenson HL, Tighe P, Wallet SM, Riley JL 3rd. Age differences in cytokine expression under conditions of health using experimental pain models. Exp Gerontol. 2015 Dec;72:150-6. doi: 10.1016/j.exger.2015.09.017. Epub 2015 Oct 9. PubMed PMID: 26456458; PubMed Central PMCID: PMC4664177.
Han S, Delitto D, Zhang D, Sorenson HL, Sarosi GA, Thomas RM, Behrns KE, Wallet SM, Trevino JG, Hughes SJ. Primary outgrowth cultures are a reliable source of human pancreatic stellate cells. Lab Invest. 2015 Nov;95(11):1331-40. doi: 10.1038/labinvest.2015.117. Epub 2015 Aug 31. PubMed PMID: 26322418.
Delitto D, Black BS, Sorenson HL, Knowlton AE, Thomas RM, Sarosi GA, Moldawer LL, Behrns KE, Liu C, George TJ, Trevino JG, Wallet SM, Hughes SJ. The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival. BMC Cancer. 2015 Oct 24;15:783. doi: 10.1186/s12885-015-1820-x. PubMed PMID: 26498838; PubMed Central PMCID: PMC4619553.
Kalash D, Vovk A, Huang H, Aukhil I, Wallet SM, Shaddox LM. Influence of Periodontal Therapy on Systemic Lipopolysaccharides in Children with Localized Aggressive Periodontitis. Pediatr Dent. 2015 Sep-Oct;37(5):35-40. PubMed PMID: 26531074; PubMed Central PMCID: PMC4634009.
Delitto D, Pham K, Vlada AC, Sarosi GA, Thomas RM, Behrns KE, Liu C, Hughes SJ, Wallet SM, Trevino JG. Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal elements. Am J Pathol. 2015 May;185(5):1297-303. doi: 10.1016/j.ajpath.2015.01.016. Epub 2015 Mar 12. PubMed PMID: 25770474; PubMed Central PMCID: PMC4419203.
Cuenca AG, Joiner DN, Gentile LF, Cuenca AL, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Behrns KE, Efron PA, Nacionales D, Lui C, Wallet SM, Reeves WH, Mathews CE, Moldawer LL. TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. J Immunol. 2015 Feb 1;194(3):1169-77. doi: 10.4049/jimmunol.1302676. Epub 2014 Dec 29. PubMed PMID: 25548220; PubMed Central PMCID: PMC4297742.
Phillips NA, Welc SS, Wallet SM, King MA, Clanton TL. Protection of intestinal injury during heat stroke in mice by interleukin-6 pretreatment. J Physiol. 2015 Feb 1;593(3):739-52; discussion 753. doi: 10.1113/jphysiol.2014.283416. Epub 2015 Jan 2. PubMed PMID: 25433073; PubMed Central PMCID: PMC4324717.
Lu S, Zeumer L, Sorensen H, Yang H, Ng Y, Yu F, Riva A, Croker B, Wallet S, Morel L. The murine Pbx1-d lupus susceptibility allele accelerates mesenchymal stem cell differentiation and impairs their immunosuppressive function. J Immunol. 2015 Jan 1;194(1):43-55. doi: 10.4049/jimmunol.1401851. PubMed PMID: 25416808.
Graves CL, Harden SW, LaPato M, Nelson M, Amador B, Sorenson H, Frazier CJ, Wallet SM. A method for high purity intestinal epithelial cell culture from adult human and murine tissues for the investigation of innate immune function. J Immunol Methods. 2014 Dec 1;414:20-31. doi: 10.1016/j.jim.2014.08.002. Epub 2014 Sep 2. PubMed PMID: 25193428; PubMed Central PMCID: PMC4384334.
Jones MK, Watanabe M, Zhu S, Graves CL, Keyes LR, Grau KR, Gonzalez-Hernandez MB, Iovine NM, Wobus CE, Vinjé J, Tibbetts SA, Wallet SM, Karst SM. Enteric bacteria promote human and mouse norovirus infection of B cells. Science. 2014 Nov 7;346(6210):755-9. doi: 10.1126/science.1257147. PubMed PMID: 25378626; PubMed Central PMCID: PMC4401463.
Neiva KG, Catalfamo DL, Holliday S, Wallet SM, Pileggi R. Propolis decreases lipopolysaccharide-induced inflammatory mediators in pulp cells and osteoclasts. Dent Traumatol. 2014 Oct;30(5):362-7. doi: 10.1111/edt.12096. Epub 2014 Feb 6. PubMed PMID: 24502251.
Koutouzis T, Mesia R, Calderon N, Wong F, Wallet S. The effect of dynamic loading on bacterial colonization of the dental implant fixture-abutment interface: an in vitro study. J Oral Implantol. 2014 Aug;40(4):432-7. doi: 10.1563/AAID-JOI-D-11-00207. PubMed PMID: 25106007.
Park E, Na HS, Kim SM, Wallet S, Cha S, Chung J. Xylitol, an anticaries agent, exhibits potent inhibition of inflammatory responses in human THP-1-derived macrophages infected with Porphyromonas gingivalis. J Periodontol. 2014 Jun;85(6):e212-23. doi: 10.1902/jop.2014.130455. Epub 2014 Mar 4. PubMed PMID: 24592909; PubMed Central PMCID: PMC4775082.
Rody WJ Jr, Holliday LS, McHugh KP, Wallet SM, Spicer V, Krokhin O. Mass spectrometry analysis of gingival crevicular fluid in the presence of external root resorption. Am J Orthod Dentofacial Orthop. 2014 Jun;145(6):787-98. doi: 10.1016/j.ajodo.2014.03.013. PubMed PMID: 24880850.
Neiva KG, Calderon NL, Alonso TR, Panagakos F, Wallet SM. Type 1 diabetes-associated TLR responsiveness of oral epithelial cells. J Dent Res. 2014 Feb;93(2):169-74. doi: 10.1177/0022034513516345. Epub 2013 Dec 13. PubMed PMID: 24334435; PubMed Central PMCID: PMC6728570.
Gonçalves PF, Klepac-Ceraj V, Huang H, Paster BJ, Aukhil I, Wallet SM, Shaddox LM. Correlation of Aggregatibacter actinomycetemcomitans detection with clinical/immunoinflammatory profile of localized aggressive periodontitis using a 16S rRNA microarray method: a cross-sectional study. PLoS One. 2013;8(12):e85066. doi: 10.1371/journal.pone.0085066. eCollection 2013. PubMed PMID: 24376864; PubMed Central PMCID: PMC3871691.
Reyes L, Eiler-McManis E, Rodrigues PH, Chadda AS, Wallet SM, Bélanger M, Barrett AG, Alvarez S, Akin D, Dunn WA Jr, Progulske-Fox A. Deletion of lipoprotein PG0717 in Porphyromonas gingivalis W83 reduces gingipain activity and alters trafficking in and response by host cells. PLoS One. 2013;8(9):e74230. doi: 10.1371/journal.pone.0074230. eCollection 2013. PubMed PMID: 24069284; PubMed Central PMCID: PMC3772042.
Shaddox LM, Gonçalves PF, Vovk A, Allin N, Huang H, Hou W, Aukhil I, Wallet SM. LPS-induced inflammatory response after therapy of aggressive periodontitis. J Dent Res. 2013 Aug;92(8):702-8. doi: 10.1177/0022034513495242. Epub 2013 Jun 20. PubMed PMID: 23788609; PubMed Central PMCID: PMC3711573.
Wallet MA, Calderon Nl, Alonso TR, Choe CS, Catalfamo Dl, Lalane CJ, Neiva KG, Panagakos F, Wallet SM. Triclosan alters antimicrobial and inflammatory responses of epithelial cells. Oral Dis. 2013 Apr;19(3):296-302. doi: 10.1111/odi.12001. PubMed PMID: 24079913; PubMed Central PMCID: PMC3800022.
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