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Hixon JA, Andrews C, Kashi L, Kohnhorst CL, Senkevitch E, Czarra K, Barata JT, Li W, Schneider JP, Walsh STR, Durum SK. New anti-IL-7Rα monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Leukemia. 2019 Aug 22;. doi: 10.1038/s41375-019-0531-8. [Epub ahead of print] PubMed PMID: 31439943.
Majumder P, Baxa U, Walsh STR, Schneider JP. Design of a Multicompartment Hydrogel that Facilitates Time-Resolved Delivery of Combination Therapy and Synergized Killing of Glioblastoma. Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15040-15044. doi: 10.1002/anie.201806483. Epub 2018 Oct 18. PubMed PMID: 30240496; PubMed Central PMCID: PMC6424348.
Sinthuvanich C, Nagy-Smith KJ, Walsh S, Schneider JP. Triggered Formation of Anionic Hydrogels from Self-Assembling Acidic Peptide Amphiphiles. Macromolecules. 2017 August; 50(15):5643-51.
Hong C, Luckey MA, Ligons DL, Waickman AT, Park JY, Kim GY, Keller HR, Etzensperger R, Tai X, Lazarevic V, Feigenbaum L, Catalfamo M, Walsh ST, Park JH. Activated T cells secrete an alternatively spliced form of common γ-chain that inhibits cytokine signaling and exacerbates inflammation. Immunity. 2014 Jun 19;40(6):910-23. doi: 10.1016/j.immuni.2014.04.020. Epub 2014 Jun 5. PubMed PMID: 24909888; PubMed Central PMCID: PMC4143255.
Lundström W, Highfill S, Walsh ST, Beq S, Morse E, Kockum I, Alfredsson L, Olsson T, Hillert J, Mackall CL. Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity. Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1761-70. doi: 10.1073/pnas.1222303110. Epub 2013 Apr 22. PubMed PMID: 23610432; PubMed Central PMCID: PMC3651437.
Walsh ST. Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway. Immunol Rev. 2012 Nov;250(1):303-16. doi: 10.1111/j.1600-065X.2012.01160.x. Review. PubMed PMID: 23046137; PubMed Central PMCID: PMC3471675.
McElroy CA, Holland PJ, Zhao P, Lim JM, Wells L, Eisenstein E, Walsh ST. Structural reorganization of the interleukin-7 signaling complex. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2503-8. doi: 10.1073/pnas.1116582109. Epub 2012 Jan 30. PubMed PMID: 22308406; PubMed Central PMCID: PMC3289338.
Wang H, Ge Z, Walsh ST, Parthun MR. The human histone chaperone sNASP interacts with linker and core histones through distinct mechanisms. Nucleic Acids Res. 2012 Jan;40(2):660-9. doi: 10.1093/nar/gkr781. Epub 2011 Sep 29. PubMed PMID: 21965532; PubMed Central PMCID: PMC3258156.
Zhang F, Liang X, Pu D, George KI, Holland PJ, Walsh ST, Linhardt RJ. Biophysical characterization of glycosaminoglycan-IL-7 interactions using SPR. Biochimie. 2012 Jan;94(1):242-9. doi: 10.1016/j.biochi.2011.10.015. Epub 2011 Nov 6. PubMed PMID: 22085638; PubMed Central PMCID: PMC3338127.
Walsh ST. A biosensor study indicating that entropy, electrostatics, and receptor glycosylation drive the binding interaction between interleukin-7 and its receptor. Biochemistry. 2010 Oct 12;49(40):8766-78. doi: 10.1021/bi101050h. Epub 2010 Sep 15. PubMed PMID: 20815339; PubMed Central PMCID: PMC3005950.
Clark KR, Walsh ST. Crystal structure of a 3B3 variant--a broadly neutralizing HIV-1 scFv antibody. Protein Sci. 2009 Dec;18(12):2429-41. doi: 10.1002/pro.255. PubMed PMID: 19785005; PubMed Central PMCID: PMC2821263.
McElroy CA, Dohm JA, Walsh ST. Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. Structure. 2009 Jan 14;17(1):54-65. doi: 10.1016/j.str.2008.10.019. PubMed PMID: 19141282; PubMed Central PMCID: PMC2654238.
Wang H, Walsh ST, Parthun MR. Expanded binding specificity of the human histone chaperone NASP. Nucleic Acids Res. 2008 Oct;36(18):5763-72. doi: 10.1093/nar/gkn574. Epub 2008 Sep 9. PubMed PMID: 18782834; PubMed Central PMCID: PMC2566879.
Wickham J Jr, Walsh ST. Crystallization and preliminary X-ray diffraction of human interleukin-7 bound to unglycosylated and glycosylated forms of its alpha-receptor. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):865-9. doi: 10.1107/S1744309107042807. Epub 2007 Sep 19. PubMed PMID: 17909291; PubMed Central PMCID: PMC2339731.
Walsh ST, Kossiakoff AA. Crystal structure and site 1 binding energetics of human placental lactogen. J Mol Biol. 2006 May 5;358(3):773-84. doi: 10.1016/j.jmb.2006.02.038. Epub 2006 Mar 2. PubMed PMID: 16546209.
Walsh ST, Sylvester JE, Kossiakoff AA. The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17078-83. doi: 10.1073/pnas.0403336101. Epub 2004 Nov 24. PubMed PMID: 15563602; PubMed Central PMCID: PMC535364.
Walsh ST, Jevitts LM, Sylvester JE, Kossiakoff AA. Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization. Protein Sci. 2003 Sep;12(9):1960-70. doi: 10.1110/ps.03133903. PubMed PMID: 12930995; PubMed Central PMCID: PMC2323993.
Walsh ST, Cheng RP, Wright WW, Alonso DO, Daggett V, Vanderkooi JM, DeGrado WF. The hydration of amides in helices; a comprehensive picture from molecular dynamics, IR, and NMR. Protein Sci. 2003 Mar;12(3):520-31. doi: 10.1110/ps.0223003. PubMed PMID: 12592022; PubMed Central PMCID: PMC2312439.
Schiffer C, Ultsch M, Walsh S, Somers W, de Vos AM, Kossiakoff A. Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites. J Mol Biol. 2002 Feb 15;316(2):277-89. doi: 10.1006/jmbi.2001.5348. PubMed PMID: 11851338.
Walsh ST, Lee AL, DeGrado WF, Wand AJ. Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods. Biochemistry. 2001 Aug 14;40(32):9560-9. doi: 10.1021/bi0105274. PubMed PMID: 11583155.
Walsh ST, Sukharev VI, Betz SF, Vekshin NL, DeGrado WF. Hydrophobic core malleability of a de novo designed three-helix bundle protein. J Mol Biol. 2001 Jan 12;305(2):361-73. doi: 10.1006/jmbi.2000.4184. PubMed PMID: 11124911.
Hardy JA, Walsh ST, Nelson HC. Role of an alpha-helical bulge in the yeast heat shock transcription factor. J Mol Biol. 2000 Jan 21;295(3):393-409. doi: 10.1006/jmbi.1999.3357. PubMed PMID: 10623534.
Wilkinson KD, Laleli-Sahin E, Urbauer J, Larsen CN, Shih GH, Haas AL, Walsh ST, Wand AJ. The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3. J Mol Biol. 1999 Sep 3;291(5):1067-77. doi: 10.1006/jmbi.1999.3038. PubMed PMID: 10518943.
Walsh ST, Cheng H, Bryson JW, Roder H, DeGrado WF. Solution structure and dynamics of a de novo designed three-helix bundle protein. Proc Natl Acad Sci U S A. 1999 May 11;96(10):5486-91. doi: 10.1073/pnas.96.10.5486. PubMed PMID: 10318910; PubMed Central PMCID: PMC21886.
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