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Reiss Y, Seabra MC, Armstrong SA, Slaughter CA, Goldstein JL, Brown MS. Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions. J Biol Chem. 1991 Jun 5;266(16):10672-7. PubMed PMID: 2037606.
Armstrong SA, Seabra MC, Südhof TC, Goldstein JL, Brown MS. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. J Biol Chem. 1993 Jun 5;268(16):12221-9. PubMed PMID: 8505342.
Andres DA, Seabra MC, Brown MS, Armstrong SA, Smeland TE, Cremers FP, Goldstein JL. cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein. Cell. 1993 Jun 18;73(6):1091-9. doi: 10.1016/0092-8674(93)90639-8. PubMed PMID: 8513495.
Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL. REP-2, a Rab escort protein encoded by the choroideremia-like gene. J Biol Chem. 1994 Jan 21;269(3):2111-7. PubMed PMID: 8294464.
Armstrong SA, Brown MS, Goldstein JL, Seabra MC. Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins. Methods Enzymol. 1995;257:30-41. doi: 10.1016/s0076-6879(95)57007-1. PubMed PMID: 8583933.
Armstrong SA, Hannah VC, Goldstein JL, Brown MS. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. J Biol Chem. 1995 Apr 7;270(14):7864-8. doi: 10.1074/jbc.270.14.7864. PubMed PMID: 7713879.
Willnow TE, Armstrong SA, Hammer RE, Herz J. Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4537-41. doi: 10.1073/pnas.92.10.4537. PubMed PMID: 7538675; PubMed Central PMCID: PMC41979.
Willnow TE, Hilpert J, Armstrong SA, Rohlmann A, Hammer RE, Burns DK, Herz J. Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8460-4. doi: 10.1073/pnas.93.16.8460. PubMed PMID: 8710893; PubMed Central PMCID: PMC38693.
Dal Cin P, Atkins L, Ford C, Ariyanayagam S, Armstrong SA, George R, Cleary A, Morton CC. Amplification of AML1 in childhood acute lymphoblastic leukemias. Genes Chromosomes Cancer. 2001 Apr;30(4):407-9. PubMed PMID: 11241794.
Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD, Sallan SE, Lander ES, Golub TR, Korsmeyer SJ. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet. 2002 Jan;30(1):41-7. doi: 10.1038/ng765. Epub 2001 Dec 3. PubMed PMID: 11731795.
Armstrong SA, Hsieh JJ, Korsmeyer SJ. Genomic approaches to the pathogenesis and treatment of acute lymphoblastic leukemias. Curr Opin Hematol. 2002 Jul;9(4):339-44. Review. PubMed PMID: 12042709.
Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M. Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. Blood. 2002 Nov 15;100(10):3710-8. doi: 10.1182/blood-2002-04-1015. Epub 2002 Jun 28. PubMed PMID: 12393701.
Armstrong SA, Kung AL, Mabon ME, Silverman LB, Stam RW, Den Boer ML, Pieters R, Kersey JH, Sallan SE, Fletcher JA, Golub TR, Griffin JD, Korsmeyer SJ. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell. 2003 Feb;3(2):173-83. PubMed PMID: 12620411.
Stam RW, den Boer ML, Meijerink JP, Ebus ME, Peters GJ, Noordhuis P, Janka-Schaub GE, Armstrong SA, Korsmeyer SJ, Pieters R. Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia. Blood. 2003 Feb 15;101(4):1270-6. doi: 10.1182/blood-2002-05-1600. Epub 2002 Oct 24. PubMed PMID: 12406912.
Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, Look AT. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood. 2003 Jul 1;102(1):262-8. doi: 10.1182/blood-2002-10-3221. Epub 2003 Mar 13. PubMed PMID: 12637319.
Armstrong SA, Korsmeyer SJ. Comparison of human genomics and genetic models of cancer to identify novel therapeutic targets. Cell Cycle. 2003 Sep-Oct;2(5):408-9. Review. PubMed PMID: 12963826.
Armstrong SA, Golub TR, Korsmeyer SJ. MLL-rearranged leukemias: insights from gene expression profiling. Semin Hematol. 2003 Oct;40(4):268-73. Review. PubMed PMID: 14582077.
Armstrong SA, Mabon ME, Silverman LB, Li A, Gribben JG, Fox EA, Sallan SE, Korsmeyer SJ. FLT3 mutations in childhood acute lymphoblastic leukemia. Blood. 2004 May 1;103(9):3544-6. doi: 10.1182/blood-2003-07-2441. Epub 2003 Dec 11. PubMed PMID: 14670924.
Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J. 2005 Jan 26;24(2):368-81. doi: 10.1038/sj.emboj.7600521. Epub 2005 Jan 6. PubMed PMID: 15635450; PubMed Central PMCID: PMC545811.
Armstrong SA, Look AT. Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol. 2005 Sep 10;23(26):6306-15. doi: 10.1200/JCO.2005.05.047. Review. PubMed PMID: 16155013.
Stam RW, den Boer ML, Schneider P, Nollau P, Horstmann M, Beverloo HB, van der Voort E, Valsecchi MG, de Lorenzo P, Sallan SE, Armstrong SA, Pieters R. Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. Blood. 2005 Oct 1;106(7):2484-90. doi: 10.1182/blood-2004-09-3667. Epub 2005 Jun 14. PubMed PMID: 15956279.
Li A, Goldwasser MA, Zhou J, Armstrong SA, Wang H, Dalton V, Fletcher JA, Sallan SE, Silverman LB, Gribben JG. Distinctive IGH gene segment usage and minimal residual disease detection in infant acute lymphoblastic leukaemias. Br J Haematol. 2005 Oct;131(2):185-92. doi: 10.1111/j.1365-2141.2005.05754.x. PubMed PMID: 16197448.
Maia S, Haining WN, Ansén S, Xia Z, Armstrong SA, Seth NP, Ghia P, den Boer ML, Pieters R, Sallan SE, Nadler LM, Cardoso AA. Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia. Cancer Res. 2005 Nov 1;65(21):10050-8. doi: 10.1158/0008-5472.CAN-05-1574. PubMed PMID: 16267031.
Levine RL, Loriaux M, Huntly BJ, Loh ML, Beran M, Stoffregen E, Berger R, Clark JJ, Willis SG, Nguyen KT, Flores NJ, Estey E, Gattermann N, Armstrong S, Look AT, Griffin JD, Bernard OA, Heinrich MC, Gilliland DG, Druker B, Deininger MW. The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood. 2005 Nov 15;106(10):3377-9. doi: 10.1182/blood-2005-05-1898. Epub 2005 Aug 4. PubMed PMID: 16081687; PubMed Central PMCID: PMC1895066.
Stam RW, den Boer ML, Passier MM, Janka-Schaub GE, Sallan SE, Armstrong SA, Pieters R. Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia. Leukemia. 2006 Feb;20(2):264-71. doi: 10.1038/sj.leu.2404074. PubMed PMID: 16357833.
Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006 May;9(5):351-65. doi: 10.1016/j.ccr.2006.03.027. PubMed PMID: 16697956.
Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature. 2006 Aug 17;442(7104):818-22. doi: 10.1038/nature04980. Epub 2006 Jul 16. PubMed PMID: 16862118.
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science. 2006 Sep 29;313(5795):1929-35. doi: 10.1126/science.1132939. PubMed PMID: 17008526.
Wei G, Twomey D, Lamb J, Schlis K, Agarwal J, Stam RW, Opferman JT, Sallan SE, den Boer ML, Pieters R, Golub TR, Armstrong SA. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell. 2006 Oct;10(4):331-42. doi: 10.1016/j.ccr.2006.09.006. Epub 2006 Sep 28. PubMed PMID: 17010674.
Sears C, Armstrong SA. Microarrays to identify new therapeutic strategies for cancer. Adv Cancer Res. 2007;96:51-74. doi: 10.1016/S0065-230X(06)96003-5. Review. PubMed PMID: 17161676.
Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegué E, DePinho RA, Gilliland DG. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007 Jan 26;128(2):325-39. doi: 10.1016/j.cell.2007.01.003. PubMed PMID: 17254970.
Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, MacConaill L, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C, Greulich H, Shah K, Sasaki H, Gazdar A, Minna J, Armstrong SA, Mellinghoff IK, Hodi FS, Dranoff G, Mischel PS, Cloughesy TF, Nelson SF, Liau LM, Mertz K, Rubin MA, Moch H, Loda M, Catalona W, Fletcher J, Signoretti S, Kaye F, Anderson KC, Demetri GD, Dummer R, Wagner S, Herlyn M, Sellers WR, Meyerson M, Garraway LA. High-throughput oncogene mutation profiling in human cancer. Nat Genet. 2007 Mar;39(3):347-51. doi: 10.1038/ng1975. Epub 2007 Feb 11. PubMed PMID: 17293865.
Wang Y, Armstrong SA. Genome-wide SNP analysis in cancer: leukemia shows the way. Cancer Cell. 2007 Apr;11(4):308-9. doi: 10.1016/j.ccr.2007.03.017. Review. PubMed PMID: 17418407.
Tissing WJ, den Boer ML, Meijerink JP, Menezes RX, Swagemakers S, van der Spek PJ, Sallan SE, Armstrong SA, Pieters R. Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells. Blood. 2007 May 1;109(9):3929-35. doi: 10.1182/blood-2006-11-056366. Epub 2007 Jan 11. PubMed PMID: 17218380.
Stubbs MC, Armstrong SA. FLT3 as a therapeutic target in childhood acute leukemia. Curr Drug Targets. 2007 Jun;8(6):703-14. doi: 10.2174/138945007780830782. Review. PubMed PMID: 17584026.
Stubbs MC, Armstrong SA. Therapeutic implications of leukemia stem cell development. Clin Cancer Res. 2007 Jun 15;13(12):3439-42. doi: 10.1158/1078-0432.CCR-06-3090. Review. PubMed PMID: 17575205.
Faber J, Armstrong SA. Mixed lineage leukemia translocations and a leukemia stem cell program. Cancer Res. 2007 Sep 15;67(18):8425-8. doi: 10.1158/0008-5472.CAN-07-0972. Review. PubMed PMID: 17875678.
Faber J, Armstrong SA. Defining leukemia stem cells in MLL-translocated leukemias: implications for novel therapeutic strategies. Klin Padiatr. 2007 Nov-Dec;219(6):306-11. doi: 10.1055/s-2007-985878. Review. PubMed PMID: 18050039.
Krivtsov AV, Armstrong SA. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer. 2007 Nov;7(11):823-33. doi: 10.1038/nrc2253. Review. PubMed PMID: 17957188.
Stubbs MC, Kim YM, Krivtsov AV, Wright RD, Feng Z, Agarwal J, Kung AL, Armstrong SA. MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment. Leukemia. 2008 Jan;22(1):66-77. doi: 10.1038/sj.leu.2404951. Epub 2007 Sep 13. PubMed PMID: 17851551; PubMed Central PMCID: PMC2936245.
Jones RJ, Armstrong SA. Cancer Stem Cells in Hematopoietic Malignancies. Biol Blood Marrow Transplant. 2008 Jan;14(Supplement 1):12-16. doi: 10.1016/j.bbmt.2007.10.012. PubMed PMID: 19122742; PubMed Central PMCID: PMC2330330.
Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A. BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood. 2008 Feb 15;111(4):2300-9. doi: 10.1182/blood-2007-06-098012. Epub 2007 Dec 4. PubMed PMID: 18056841; PubMed Central PMCID: PMC2234061.
Wang Y, Armstrong SA. Cancer: inappropriate expression of stem cell programs?. Cell Stem Cell. 2008 Apr 10;2(4):297-9. doi: 10.1016/j.stem.2008.03.014. PubMed PMID: 18397746.
Faber J, Gregory RI, Armstrong SA. Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell. 2008 Jun;13(6):467-9. doi: 10.1016/j.ccr.2008.05.013. PubMed PMID: 18538729.
Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU, Xia X, Jesneck J, Bracken AP, Silverman LB, Kutok JL, Kung AL, Armstrong SA. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell. 2008 Nov 4;14(5):355-68. doi: 10.1016/j.ccr.2008.10.001. PubMed PMID: 18977325; PubMed Central PMCID: PMC2591932.
Bernt KM, Armstrong SA. Leukemia stem cells and human acute lymphoblastic leukemia. Semin Hematol. 2009 Jan;46(1):33-8. doi: 10.1053/j.seminhematol.2008.09.010. Review. PubMed PMID: 19100366; PubMed Central PMCID: PMC4031465.
Krivtsov AV, Wang Y, Feng Z, Armstrong SA. Gene expression profiling of leukemia stem cells. Methods Mol Biol. 2009;538:231-46. doi: 10.1007/978-1-59745-418-6_11. PubMed PMID: 19277590; PubMed Central PMCID: PMC3339407.
Faber J, Krivtsov AV, Stubbs MC, Wright R, Davis TN, van den Heuvel-Eibrink M, Zwaan CM, Kung AL, Armstrong SA. HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood. 2009 Mar 12;113(11):2375-85. doi: 10.1182/blood-2007-09-113597. Epub 2008 Dec 3. PubMed PMID: 19056693; PubMed Central PMCID: PMC2656267.
Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK. Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 2009 Apr 9;113(15):3461-71. doi: 10.1182/blood-2008-07-167577. Epub 2009 Feb 11. PubMed PMID: 19211936; PubMed Central PMCID: PMC2945827.
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