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Nahon KJ, Janssen LGM, SardjoeMishre ASD, Bilsen MP, van der Eijk JA, Botani K, Overduin LA, Ruiz JR, Burakiewicz J, Dzyubachyk O, Webb AG, Kan HE, Berbée JFP, van Klinken JB, van Dijk KW, van Weeghel M, Vaz FM, Coskun T, Jazet IM, Kooijman S, Martinez-Tellez B, Boon MR, Rensen PCN. The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men. Diabetes Obes Metab. 2020 Jun 18;. doi: 10.1111/dom.14120. [Epub ahead of print] PubMed PMID: 32558052.
van Alem CMA, Schmidbauer M, Rong S, Derlin K, Schmitz J, Bräsen JH, Thorenz A, Chen R, Ruben JM, Winter EM, Schilperoort M, Kooijman S, Lalai RA, Metselaar JM, Klemann C, Meier M, van Kooten C, Gueler F, Rotmans JI. Liposomal Delivery Improves the Efficacy of Prednisolone to Attenuate Renal Inflammation in a Mouse Model of Acute Renal Allograft Rejection. Transplantation. 2020 Apr;104(4):744-753. doi: 10.1097/TP.0000000000003060. PubMed PMID: 31929419; PubMed Central PMCID: PMC7147400.
Janssen LGM, Van Dam AD, Hanssen MJW, Kooijman S, Nahon KJ, Reinders H, Jazet IM, Van Marken Lichtenbelt WD, Rensen PCN, Appelman-Dijkstra NM, Boon MR. Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men. Diabetes Metab J. 2020 Apr;44(2):326-335. doi: 10.4093/dmj.2019.0031. Epub 2019 Oct 31. PubMed PMID: 31701693; PubMed Central PMCID: PMC7188965.
Hoekstra M, van der Sluis RJ, Hildebrand RB, Lammers B, Zhao Y, Praticò D, van Berkel TJC, Rensen PCN, Kooijman S, Jauhiainen M, van Eck M. Disruption of Phospholipid Transfer Protein-Mediated High-Density Lipoprotein Maturation Reduces Scavenger Receptor BI Deficiency-Driven Atherosclerosis Susceptibility Despite Unexpected Metabolic Complications. Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):611-623. doi: 10.1161/ATVBAHA.119.313862. Epub 2020 Jan 16. PubMed PMID: 31941380.
Schilperoort M, Bravenboer N, Lim J, Mletzko K, Busse B, van Ruijven L, Kroon J, Rensen PCN, Kooijman S, Winter EM. Circadian disruption by shifting the light-dark cycle negatively affects bone health in mice. FASEB J. 2020 Jan;34(1):1052-1064. doi: 10.1096/fj.201901929R. Epub 2019 Nov 28. PubMed PMID: 31914701.
Schilperoort M, van den Berg R, Bosmans LA, van Os BW, Dollé MET, Smits NAM, Guichelaar T, van Baarle D, Koemans L, Berbée JFP, Deboer T, Meijer JH, de Vries MR, Vreeken D, van Gils JM, Willems van Dijk K, van Kerkhof LWM, Lutgens E, Biermasz NR, Rensen PCN, Kooijman S. Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice. J Pineal Res. 2020 Jan;68(1):e12614. doi: 10.1111/jpi.12614. Epub 2019 Oct 10. PubMed PMID: 31599473; PubMed Central PMCID: PMC6916424.
Herrera Moro Chao D, Wang Y, Foppen E, Ottenhoff R, van Roomen C, Parlevliet ET, van Eijk M, Verhoek M, Boot R, Marques AR, Scheij S, Mirzaian M, Kooijman S, Jansen K, Wang D, Mergen C, Seeley RJ, Tschöp MH, Overkleeft H, Rensen PCN, Kalsbeek A, Aerts JMFG, Yi CX. The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1. Diabetes. 2019 Dec;68(12):2223-2234. doi: 10.2337/db19-0049. Epub 2019 Oct 2. PubMed PMID: 31578192.
Liu J, Kuipers EN, Sips HCM, Dorleijn JC, van Dam AD, Christodoulides C, Karpe F, Zhou G, Boon MR, Rensen PCN, de Vries AAF, Kooijman S. Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158511. doi: 10.1016/j.bbalip.2019.08.007. Epub 2019 Aug 26. PubMed PMID: 31465889.
Kuipers EN, Held NM, In Het Panhuis W, Modder M, Ruppert PMM, Kersten S, Kooijman S, Guigas B, Houtkooper RH, Rensen PCN, Boon MR. A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E820-E830. doi: 10.1152/ajpendo.00123.2019. Epub 2019 Aug 6. PubMed PMID: 31386566.
Noordam R, Ramkisoensing A, Loh NY, Neville MJ, Rosendaal FR, Willems van Dijk K, van Heemst D, Karpe F, Christodoulides C, Kooijman S. Associations of Outdoor Temperature, Bright Sunlight, and Cardiometabolic Traits in Two European Population-Based Cohorts. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2903-2910. doi: 10.1210/jc.2018-02532. PubMed PMID: 30759251; PubMed Central PMCID: PMC6543772.
Donkers JM, Kooijman S, Slijepcevic D, Kunst RF, Roscam Abbing RL, Haazen L, de Waart DR, Levels JH, Schoonjans K, Rensen PC, Oude Elferink RP, van de Graaf SF. NTCP deficiency in mice protects against obesity and hepatosteatosis. JCI Insight. 2019 Jun 25;5. doi: 10.1172/jci.insight.127197. PubMed PMID: 31237863; PubMed Central PMCID: PMC6675549.
Schilperoort M, van den Berg R, Dollé MET, van Oostrom CTM, Wagner K, Tambyrajah LL, Wackers P, Deboer T, Hulsegge G, Proper KI, van Steeg H, Roenneberg T, Biermasz NR, Rensen PCN, Kooijman S, van Kerkhof LWM. Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. Sci Rep. 2019 May 27;9(1):7874. doi: 10.1038/s41598-019-44398-7. PubMed PMID: 31133707; PubMed Central PMCID: PMC6536683.
Mishra D, Richard JE, Maric I, Porteiro B, Häring M, Kooijman S, Musovic S, Eerola K, López-Ferreras L, Peris E, Grycel K, Shevchouk OT, Micallef P, Olofsson CS, Wernstedt Asterholm I, Grill HJ, Nogueiras R, Skibicka KP. Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism. Cell Rep. 2019 Mar 12;26(11):3011-3026.e5. doi: 10.1016/j.celrep.2019.02.044. PubMed PMID: 30865890; PubMed Central PMCID: PMC6418345.
Nahon JE, Hoekstra M, van Harmelen V, Rensen PCN, Willems van Dijk K, Kooijman S, Van Eck M. Proteoglycan 4 deficiency protects against glucose intolerance and fatty liver disease in diet-induced obese mice. Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):494-501. doi: 10.1016/j.bbadis.2018.11.009. Epub 2018 Nov 15. PubMed PMID: 30448542.
Kuipers EN, Kantae V, Maarse BCE, van den Berg SM, van Eenige R, Nahon KJ, Reifel-Miller A, Coskun T, de Winther MPJ, Lutgens E, Kooijman S, Harms AC, Hankemeier T, van der Stelt M, Rensen PCN, Boon MR. High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue. Front Physiol. 2018;9:1913. doi: 10.3389/fphys.2018.01913. eCollection 2018. PubMed PMID: 30687125; PubMed Central PMCID: PMC6335353.
Bijkerk R, Trimpert C, van Solingen C, de Bruin RG, Florijn BW, Kooijman S, van den Berg R, van der Veer EP, Bredewold EOW, Rensen PCN, Rabelink TJ, Humphreys BD, Deen PMT, van Zonneveld AJ. MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis. Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1129-F1138. doi: 10.1152/ajprenal.00087.2018. Epub 2018 May 30. PubMed PMID: 29846108.
Spaanderman DCE, Nixon M, Buurstede JC, Sips HC, Schilperoort M, Kuipers EN, Backer EA, Kooijman S, Rensen PCN, Homer NZM, Walker BR, Meijer OC, Kroon J. Androgens modulate glucocorticoid receptor activity in adipose tissue and liver. J Endocrinol. 2018 Oct 1;. doi: 10.1530/JOE-18-0503. [Epub ahead of print] PubMed PMID: 30400038.
van Loon NM, Ottenhoff R, Kooijman S, Moeton M, Scheij S, Roscam Abbing RLP, Gijbels MJJ, Levels JHM, Sorrentino V, Berbée JFP, Rensen PCN, Zelcer N. Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice. Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1785-1795. doi: 10.1161/ATVBAHA.118.311168. PubMed PMID: 29903737; PubMed Central PMCID: PMC6092113.
Li Z, Yi CX, Katiraei S, Kooijman S, Zhou E, Chung CK, Gao Y, van den Heuvel JK, Meijer OC, Berbée JFP, Heijink M, Giera M, Willems van Dijk K, Groen AK, Rensen PCN, Wang Y. Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit. Gut. 2018 Jul;67(7):1269-1279. doi: 10.1136/gutjnl-2017-314050. Epub 2017 Nov 3. PubMed PMID: 29101261.
van Eenige R, van der Stelt M, Rensen PCN, Kooijman S. Regulation of Adipose Tissue Metabolism by the Endocannabinoid System. Trends Endocrinol Metab. 2018 May;29(5):326-337. doi: 10.1016/j.tem.2018.03.001. Epub 2018 Mar 24. Review. PubMed PMID: 29588112.
van den Berg R, Kooijman S, Noordam R, Ramkisoensing A, Abreu-Vieira G, Tambyrajah LL, Dijk W, Ruppert P, Mol IM, Kramar B, Caputo R, Puig LS, de Ruiter EM, Kroon J, Hoekstra M, van der Sluis RJ, Meijer OC, Willems van Dijk K, van Kerkhof LWM, Christodoulides C, Karpe F, Gerhart-Hines Z, Kersten S, Meijer JH, Coomans CP, van Heemst D, Biermasz NR, Rensen PCN. A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening. Cell Rep. 2018 Mar 27;22(13):3521-3533. doi: 10.1016/j.celrep.2018.03.004. PubMed PMID: 29590620.
Schilperoort M, van Dam AD, Hoeke G, Shabalina IG, Okolo A, Hanyaloglu AC, Dib LH, Mol IM, Caengprasath N, Chan YW, Damak S, Miller AR, Coskun T, Shimpukade B, Ulven T, Kooijman S, Rensen PC, Christian M. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. EMBO Mol Med. 2018 Mar;10(3). doi: 10.15252/emmm.201708047. PubMed PMID: 29343498; PubMed Central PMCID: PMC5840546.
Eggink HM, Tambyrajah LL, van den Berg R, Mol IM, van den Heuvel JK, Koehorst M, Groen AK, Boelen A, Kalsbeek A, Romijn JA, Rensen PCN, Kooijman S, Soeters MR. Chronic infusion of taurolithocholate into the brain increases fat oxidation in mice. J Endocrinol. 2018 Feb;236(2):85-97. doi: 10.1530/JOE-17-0503. Epub 2017 Dec 12. PubMed PMID: 29233934.
van den Berg R, Noordam R, Kooijman S, Jansen SWM, Akintola AA, Slagboom PE, Pijl H, Rensen PCN, Biermasz NR, van Heemst D. Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals. Aging Cell. 2017 Apr;16(2):237-243. doi: 10.1111/acel.12547. Epub 2016 Nov 19. PubMed PMID: 28440906; PubMed Central PMCID: PMC5334529.
Paulin N, Döring Y, Kooijman S, Blanchet X, Viola JR, de Jong R, Mandl M, Hendrikse J, Schiener M, von Hundelshausen P, Vogt A, Weber C, Bdeir K, Hofmann SM, Rensen PCN, Drechsler M, Soehnlein O. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. EBioMedicine. 2017 Feb;16:204-211. doi: 10.1016/j.ebiom.2017.01.006. Epub 2017 Jan 7. PubMed PMID: 28111237; PubMed Central PMCID: PMC5474437.
Deng H, Kooijman S, van den Nieuwendijk AM, Ogasawara D, van der Wel T, van Dalen F, Baggelaar MP, Janssen FJ, van den Berg RJ, den Dulk H, Cravatt BF, Overkleeft HS, Rensen PC, van der Stelt M. Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem. 2017 Jan 12;60(1):428-440. doi: 10.1021/acs.jmedchem.6b01482. Epub 2016 Dec 19. PubMed PMID: 27992221.
Kroon J, Kooijman S, Cho NJ, Storm G, van der Pluijm G. Improving Taxane-Based Chemotherapy in Castration-Resistant Prostate Cancer. Trends Pharmacol Sci. 2016 Jun;37(6):451-462. doi: 10.1016/j.tips.2016.03.003. Epub 2016 Apr 8. Review. PubMed PMID: 27068431.
Schilperoort M, Hoeke G, Kooijman S, Rensen PC. Relevance of lipid metabolism for brown fat visualization and quantification. Curr Opin Lipidol. 2016 Jun;27(3):242-8. doi: 10.1097/MOL.0000000000000296. Review. PubMed PMID: 27023630.
Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M. USF1 deficiency activates brown adipose tissue and improves cardiometabolic health. Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015. PubMed PMID: 26819196.
Hoeke G, Kooijman S, Boon MR, Rensen PC, Berbée JF. Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis. Circ Res. 2016 Jan 8;118(1):173-82. doi: 10.1161/CIRCRESAHA.115.306647. Review. PubMed PMID: 26837747.
Kazem S, Lauber C, van der Meijden E, Kooijman S, Kravchenko AA, Feltkamp MC, Gorbalenya AE. Limited variation during circulation of a polyomavirus in the human population involves the COCO-VA toggling site of Middle and Alternative T-antigen(s). Virology. 2016 Jan;487:129-40. doi: 10.1016/j.virol.2015.09.013. Epub 2015 Nov 2. PubMed PMID: 26519899.
Kooijman S, de Jonge WJ, Rensen PC. Reply to "Letter to the editor: Parasympathetic innervation of the rodent spleen?". Am J Physiol Heart Circ Physiol. 2015 Dec 15;309(12):H2159. doi: 10.1152/ajpheart.00805.2015. PubMed PMID: 26671470.
van Beek L, Vroegrijk IO, Katiraei S, Heemskerk MM, van Dam AD, Kooijman S, Rensen PC, Koning F, Verbeek JS, Willems van Dijk K, van Harmelen V. FcRγ-chain deficiency reduces the development of diet-induced obesity. Obesity (Silver Spring). 2015 Dec;23(12):2435-44. doi: 10.1002/oby.21309. Epub 2015 Nov 2. PubMed PMID: 26523352.
Kooijman S, Wang Y, Parlevliet ET, Boon MR, Edelschaap D, Snaterse G, Pijl H, Romijn JA, Rensen PC. Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice. Diabetologia. 2015 Nov;58(11):2637-46. doi: 10.1007/s00125-015-3727-0. Epub 2015 Aug 9. PubMed PMID: 26254578; PubMed Central PMCID: PMC4589565.
Kooijman S, van den Heuvel JK, Rensen PCN. Neuronal Control of Brown Fat Activity. Trends Endocrinol Metab. 2015 Nov;26(11):657-668. doi: 10.1016/j.tem.2015.09.008. Epub 2015 Oct 17. Review. PubMed PMID: 26482876.
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR. Regulation of brown fat by AMP-activated protein kinase. Trends Mol Med. 2015 Sep;21(9):571-9. doi: 10.1016/j.molmed.2015.07.003. Epub 2015 Aug 10. Review. PubMed PMID: 26271143.
Coomans CP, Lucassen EA, Kooijman S, Fifel K, Deboer T, Rensen PC, Michel S, Meijer JH. Plasticity of circadian clocks and consequences for metabolism. Diabetes Obes Metab. 2015 Sep;17 Suppl 1:65-75. doi: 10.1111/dom.12513. Review. PubMed PMID: 26332970.
Kooijman S, Meurs I, van Beek L, Khedoe PP, Giezekamp A, Pike-Overzet K, Cailotto C, van der Vliet J, van Harmelen V, Boeckxstaens G, Berbée JF, Rensen PC. Splenic autonomic denervation increases inflammatory status but does not aggravate atherosclerotic lesion development. Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H646-54. doi: 10.1152/ajpheart.00787.2014. Epub 2015 Jun 19. PubMed PMID: 26092978.
Kooijman S, van den Berg R, Ramkisoensing A, Boon MR, Kuipers EN, Loef M, Zonneveld TC, Lucassen EA, Sips HC, Chatzispyrou IA, Houtkooper RH, Meijer JH, Coomans CP, Biermasz NR, Rensen PC. Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6748-53. doi: 10.1073/pnas.1504239112. Epub 2015 May 11. PubMed PMID: 25964318; PubMed Central PMCID: PMC4450411.
van Dam AD, Nahon KJ, Kooijman S, van den Berg SM, Kanhai AA, Kikuchi T, Heemskerk MM, van Harmelen V, Lombès M, van den Hoek AM, de Winther MP, Lutgens E, Guigas B, Rensen PC, Boon MR. Salsalate activates brown adipose tissue in mice. Diabetes. 2015 May;64(5):1544-54. doi: 10.2337/db14-1125. Epub 2014 Dec 4. PubMed PMID: 25475439.
Berbée JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun. 2015 Mar 10;6:6356. doi: 10.1038/ncomms7356. PubMed PMID: 25754609; PubMed Central PMCID: PMC4366535.
Rozema E, van Dam A, Sips H, Verporte R, Meijer O, Kooijman S, Choi Y. Extending pharmacological dose-response curves for salsalate with natural deep eutectic solvents. RSC advances. 2015; 5:61398. doi: 10.1039/C5RA10196D.
Kooijman S, Meurs I, van der Stoep M, Habets KL, Lammers B, Berbée JF, Havekes LM, van Eck M, Romijn JA, Korporaal SJ, Rensen PC. Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis. J Thromb Haemost. 2015 Jan;13(1):126-35. doi: 10.1111/jth.12765. Epub 2014 Nov 13. PubMed PMID: 25345495.
Khedoe PP, Hoeke G, Kooijman S, Dijk W, Buijs JT, Kersten S, Havekes LM, Hiemstra PS, Berbée JF, Boon MR, Rensen PC. Brown adipose tissue takes up plasma triglycerides mostly after lipolysis. J Lipid Res. 2015 Jan;56(1):51-9. doi: 10.1194/jlr.M052746. Epub 2014 Oct 28. PubMed PMID: 25351615; PubMed Central PMCID: PMC4274071.
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbée JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombès M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC. Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity. FASEB J. 2014 Dec;28(12):5361-75. doi: 10.1096/fj.13-247643. Epub 2014 Aug 25. PubMed PMID: 25154875.
Kooijman S, Boon MR, Parlevliet ET, Geerling JJ, van de Pol V, Romijn JA, Havekes LM, Meurs I, Rensen PC. Inhibition of the central melanocortin system decreases brown adipose tissue activity. J Lipid Res. 2014 Oct;55(10):2022-32. doi: 10.1194/jlr.M045989. Epub 2014 Jul 12. PubMed PMID: 25016380; PubMed Central PMCID: PMC4173995.
Geerling JJ, Boon MR, Kooijman S, Parlevliet ET, Havekes LM, Romijn JA, Meurs IM, Rensen PC. Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies. J Lipid Res. 2014 Feb;55(2):180-9. doi: 10.1194/jlr.R045013. Epub 2013 Nov 27. Review. PubMed PMID: 24285857; PubMed Central PMCID: PMC3886657.
Bruinstroop E, la Fleur SE, Ackermans MT, Foppen E, Wortel J, Kooijman S, Berbée JF, Rensen PC, Fliers E, Kalsbeek A. The autonomic nervous system regulates postprandial hepatic lipid metabolism. Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1089-96. doi: 10.1152/ajpendo.00614.2012. Epub 2013 Mar 26. PubMed PMID: 23531617.
Kazem S, van der Meijden E, Kooijman S, Rosenberg AS, Hughey LC, Browning JC, Sadler G, Busam K, Pope E, Benoit T, Fleckman P, de Vries E, Eekhof JA, Feltkamp MC. Trichodysplasia spinulosa is characterized by active polyomavirus infection. J Clin Virol. 2012 Mar;53(3):225-30. doi: 10.1016/j.jcv.2011.11.007. Epub 2011 Dec 22. PubMed PMID: 22196870.
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