My Bibliography

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Denlinger LC, Israel E, Moore WC, Georas SN, Wright RJ, Castro M, Peden DB, Anstrom KJ, Bleecker ER, Alexander LC, Cahill KN, Cardet JC, Carr TF, Cedano J, Chen AY, Chupp GL, Comhair SAA, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Jackson DJ, Jain S, Jarjour NN, Kenyon NJ, Kraft M, Krishnan JA, Kumar R, Lugogo NL, Martinez FD, Marquis MA, Pappalardo AA, Phipatanakul W, Rank MA, Rosenberg SR, Salciccioli JD, Sanchez M, Smith LJ, Sumino K, Szefler SJ, Tang M, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A, Bacharier LB, Akuthota P, NHLBI PrecISE Study Team. PrecISE-a biomarker-stratified adaptive trial of 5 interventions in severe asthma: Final protocol and the baseline cohort. J Allergy Clin Immunol. 2026 Jun;157(6):1261-1273. doi: 10.1016/j.jaci.2026.02.001. Epub 2026 Feb 16. PubMed PMID: 41707916; PubMed Central PMCID: PMC13352393.

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Schworer SA, Murano H, Dang H, Markovetz MR, Saito M, Kato T, Asakura T, Chen G, Gilmore RC, Morton LC, Van Heusden C, Chua M, Strickler E, Wisniewski ZY, Crisp G, Mitchell E, Doherty KA, Mastan S, Trejo Bittar HE, Cody BA, Trudeau JB, De La Cruz G, Ralph LM, Askin FB, Panettieri RA, Koziol-White CJ, Byrd KM, Livraghi-Butrico A, O'Neal WK, Randell SH, Wenzel SE, Okuda K, Boucher RC. Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles. Am J Respir Crit Care Med. 2026 Feb 1;212(2):209-226. doi: 10.1164/rccm.202409-1849OC. PubMed PMID: 40986379; PubMed Central PMCID: PMC12668797.

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Khanna K, Tang M, Jackson ND, Johansson MW, Bleecker ER, Castro M, Comhair SA, Denlinger LC, Erzurum SC, Hastie AT, Moore W, Israel E, Levy BD, Jarjour NN, Mauger DT, Phillips BR, Sumino K, Wenzel SE, Woodruff PG, Seibold MA, Fahy JV, National Heart . High airway thymic stromal lymphopoietin in asthma is associated with type 2 inflammation, mucus plugging, and airway remodeling. J Allergy Clin Immunol. 2026 Mar;157(3):616-626. doi: 10.1016/j.jaci.2025.11.014. Epub 2025 Dec 13. PubMed PMID: 41397482.

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Prasad C, Griffard R, Pei D, Haworth S, Dhillon NK, Castro M, Sundar IK. Extracellular Vesicle miRNAs as Biomarkers of Asthma Severity. Allergy. 2026 Jan;81(1):271-276. doi: 10.1111/all.70079. Epub 2025 Sep 30. PubMed PMID: 41025688; PubMed Central PMCID: PMC13085337.

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Gómez LF, Kinnee EJ, Young MT, Kaufman JD, Fitzpatrick AM, Nyenhuis SM, Solway J, White SR, Naureckas ET, Phipatanakul W, Wechsler ME, Kunselman SJ, Mauger DT, McClure LA, Bilal U, Lazarus SC, Holguin F, Clougherty JE. Asthma treatment response modified by fine particulate matter, nitrogen dioxide, and ozone among Black children: A reanalysis of the AsthmaNet Best African American Response to Asthma Drugs trial. J Allergy Clin Immunol. 2025 Aug;156(2):330-338. doi: 10.1016/j.jaci.2025.04.009. Epub 2025 Apr 15. PubMed PMID: 40245951; PubMed Central PMCID: PMC12286556.

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Ramonell RP, Oriss TB, McCreary-Partyka JC, Kale SL, Brandon NR, Ross MA, Gauthier MC, Yue M, Nee TJ, Das S, Chen W, Joglekar AV, Ray P, St Croix CM, Rajasundaram D, Wenzel SE, Ray A. CD8+ TEMRAs in severe asthma associate with asthma symptom duration and escape proliferation arrest. JCI Insight. 2025 Apr 22;10(8). doi: 10.1172/jci.insight.185061. eCollection 2025 Apr 22. PubMed PMID: 40048261; PubMed Central PMCID: PMC12016929.

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Gauthier M, Kale SL, Ray A. T1-T2 Interplay in the Complex Immune Landscape of Severe Asthma. Immunol Rev. 2025 Mar;330(1):e70011. doi: 10.1111/imr.70011. Review. PubMed PMID: 39991821; PubMed Central PMCID: PMC11849004.

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Ortega VE, Tejwani V, Shrivastav AK, Pasha S, Zein JG, Boorgula M, Castro M, Denlinger L, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Levy B, Mauger D, Moore WC, Wenzel SE, Woodruff P, Hawkins GA, Bleecker ER, Meyers DA, NHLBI Severe Asthma Research Program (SARP). α(1)-Antitrypsin Gene Variation Associates With Asthma Exacerbations and Related Health Care Utilization. J Allergy Clin Immunol Pract. 2025 Jul;13(7):1634-1646.e7. doi: 10.1016/j.jaip.2025.01.039. Epub 2025 Feb 13. PubMed PMID: 39954727; PubMed Central PMCID: PMC13285010.

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Serhan CN, Levy BD. Proresolving Lipid Mediators in the Respiratory System. Annu Rev Physiol. 2025 Feb;87(1):491-512. doi: 10.1146/annurev-physiol-020924-033209. Epub 2025 Feb 3. Review. PubMed PMID: 39303274; PubMed Central PMCID: PMC11810588.

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Flack KF, George MD, Kim JS, Hsu JY, Podolanczuk AJ, Hoffman EA, Johnson C, McGroder CF, Smith BM, Kreider M, Kawut SM, Barr RG, Anderson MR, Bernstein EJ. Antinuclear antibodies and progression of quantitative interstitial lung changes: The Multi-Ethnic Study of Atherosclerosis (MESA)-Lung Study. Respir Med. 2025 Mar;238:107955. doi: 10.1016/j.rmed.2025.107955. Epub 2025 Jan 23. PubMed PMID: 39855480; PubMed Central PMCID: PMC11851077.

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Ramonell RP, Gauthier MC, Ray A, Wenzel SE. Biologic Medications for Severe Asthma: Implications for Understanding Pathogenic Heterogeneity and Endotypes. Annu Rev Med. 2025 Jan;76(1):339-355. doi: 10.1146/annurev-med-070323-103158. Epub 2025 Jan 16. Review. PubMed PMID: 39586024; PubMed Central PMCID: PMC12830064.

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Ramonell RP, Choi P, Gauthier MC, Fajt ML, Ray A, Wenzel SE. Development of rheumatoid arthritis in patients with asthma: A case series. J Allergy Clin Immunol Pract. 2025 Mar;13(3):692-694.e2. doi: 10.1016/j.jaip.2024.12.015. Epub 2024 Dec 19. PubMed PMID: 39709052; PubMed Central PMCID: PMC11885025.

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Boomer J, Choi J, Alsup A, McGregor MC, Lieu J, Johnson C, Hall C, Shi X, Kim T, Goss C, Lew D, Christensen S, Woodruff P, Hastie A, Mauger D, Wenzel SE, Hoffman E, Schechtman KB, Castro M. Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor. Am J Respir Crit Care Med. 2024 Dec 15;210(12):1409-1420. doi: 10.1164/rccm.202307-1266OC. PubMed PMID: 38935626; PubMed Central PMCID: PMC11716027.

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Gómez LF, Kinnee E, Kaufman JD, Young MT, Fitzpatrick AM, Phipatanakul W, Mauger DT, McClure LA, Bilal U, Holguin F, Clougherty JE. Modification of asthma treatment efficacy by healthcare access: A reanalysis of AsthmaNet Step-Up Yellow Zone Inhaled Corticosteroids to Prevent Exacerbations (STICS) clinical trial. Respir Med. 2024 Nov-Dec;234:107853. doi: 10.1016/j.rmed.2024.107853. Epub 2024 Nov 5. PubMed PMID: 39510322; PubMed Central PMCID: PMC11960804.

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Xu W, Hong YS, Hu B, Comhair SAA, Janocha AJ, Zein JG, Chen R, Meyers DA, Mauger DT, Ortega VE, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Gaston B, Liu C, Arking DE, Erzurum SC, National Heart . Mitochondrial DNA copy number variation in asthma risk, severity, and exacerbations. J Allergy Clin Immunol. 2025 Apr;155(4):1224-1235. doi: 10.1016/j.jaci.2024.08.022. Epub 2024 Sep 3. PubMed PMID: 39237012; PubMed Central PMCID: PMC11875079.

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Yamada K, St Croix C, Stolz DB, Tyurina YY, Tyurin VA, Bradley LR, Kapralov AA, Deng Y, Zhou X, Wei Q, Liao B, Fukuda N, Sullivan M, Trudeau J, Ray A, Kagan VE, Zhao J, Wenzel SE. Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes. Nat Commun. 2024 Jul 10;15(1):5818. doi: 10.1038/s41467-024-50222-2. PubMed PMID: 38987265; PubMed Central PMCID: PMC11237105.

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Hu H, Wang X, Feng S, Xu Z, Liu J, Heidrich-O'Hare E, Chen Y, Yue M, Zeng L, Rong Z, Chen T, Billiar T, Ding Y, Huang H, Duerr RH, Chen W. A unified model-based framework for doublet or multiplet detection in single-cell multiomics data. Nat Commun. 2024 Jul 2;15(1):5562. doi: 10.1038/s41467-024-49448-x. PubMed PMID: 38956023; PubMed Central PMCID: PMC11220103.

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Steffan BN, Townsend EA, Denlinger LC, Johansson MW. Eosinophil-Epithelial Cell Interactions in Asthma. Int Arch Allergy Immunol. 2024;185(11):1033-1047. doi: 10.1159/000539309. Epub 2024 Jun 17. Review. PubMed PMID: 38885626; PubMed Central PMCID: PMC11534548.

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Everman JL, Sajuthi SP, Liegeois MA, Jackson ND, Collet EH, Peters MC, Chioccioli M, Moore CM, Patel BB, Dyjack N, Powell R, Rios C, Montgomery MT, Eng C, Elhawary JR, Mak ACY, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen GL, Michel CR, Gomez J, Zhang X, Medina V, Chu HW, Cicuta P, Gordon ED, Zeitlin P, Ortega VE, Reisdorph N, Dunican EM, Tang M, Elicker BM, Henry TS, Bleecker ER, Castro M, Erzurum SC, Israel E, Levy BD, Mauger DT, Meyers DA, Sumino K, Gierada DS, Hastie AT, Moore WC, Denlinger LC, Jarjour NN, Schiebler ML, Wenzel SE, Woodruff PG, Rodriguez-Santana J, Pearson CG, Burchard EG, Fahy JV, Seibold MA. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nat Commun. 2024 May 9;15(1):3900. doi: 10.1038/s41467-024-48034-5. PubMed PMID: 38724552; PubMed Central PMCID: PMC11082194.

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Hastie AT, Bishop AC, Khan MS, Bleecker ER, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Levy BD, Mauger DT, Meyers DA, Moore WC, Ortega VE, Peters SP, Wenzel SE, Steele CH. Protein-Protein interactive networks identified in bronchoalveolar lavage of severe compared to nonsevere asthma. Clin Exp Allergy. 2024 Apr;54(4):265-277. doi: 10.1111/cea.14447. Epub 2024 Jan 22. PubMed PMID: 38253462; PubMed Central PMCID: PMC11075125.

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Samovich SN, Mikulska-Ruminska K, Dar HH, Tyurina YY, Tyurin VA, Souryavong AB, Kapralov AA, Amoscato AA, Beharier O, Karumanchi SA, St Croix CM, Yang X, Holman TR, VanDemark AP, Sadovsky Y, Mallampalli RK, Wenzel SE, Gu W, Bunimovich YL, Bahar I, Kagan VE, Bayir H. Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death. Angew Chem Int Ed Engl. 2024 Feb 26;63(9):e202314710. doi: 10.1002/anie.202314710. Epub 2024 Jan 17. PubMed PMID: 38230815; PubMed Central PMCID: PMC11068323.

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Ray A, Kale SL, Ramonell RP. Bridging the Gap between Innate and Adaptive Immunity in the Lung: Summary of the Aspen Lung Conference 2022. Am J Respir Cell Mol Biol. 2023 Sep;69(3):266-280. doi: 10.1165/rcmb.2023-0057WS. PubMed PMID: 37043828; PubMed Central PMCID: PMC10503303.

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Kawakami Y, Takazawa I, Fajt ML, Kasakura K, Lin J, Ferrer J, Kantor DB, Phipatanakul W, Heymann PW, Benedict CA, Kawakami Y, Kawakami T. Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation. J Allergy Clin Immunol. 2023 Sep;152(3):633-640.e4. doi: 10.1016/j.jaci.2023.04.021. Epub 2023 Jun 8. PubMed PMID: 37301412; PubMed Central PMCID: PMC10917146.

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Byrwa-Hill BM, Morphew TL, Presto AA, Fabisiak JP, Wenzel SE. Living in environmental justice areas worsens asthma severity and control: Differential interactions with disease duration, age at onset, and pollution. J Allergy Clin Immunol. 2023 Nov;152(5):1321-1329.e5. doi: 10.1016/j.jaci.2023.04.015. Epub 2023 May 6. PubMed PMID: 37156327; PubMed Central PMCID: PMC10626048.

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Li X, Li H, Christenson SA, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Bleecker ER, Meyers DA, NHLBI Severe Asthma Research Program (SARP). Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes. J Asthma. 2023 Oct;60(10):1824-1835. doi: 10.1080/02770903.2023.2193631. Epub 2023 Apr 21. PubMed PMID: 36946148; PubMed Central PMCID: PMC10524756.

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Li H, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Wenzel SE, Zein J, Bleecker ER, Meyers DA, Chen Y, Li X, NHLBI Severe Asthma Research Program (SARP). Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes. J Asthma. 2023 Oct;60(10):1843-1852. doi: 10.1080/02770903.2023.2193634. Epub 2023 Apr 21. PubMed PMID: 36940238; PubMed Central PMCID: PMC10528448.

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Gauthier M, Kale SL, Oriss TB, Gorry M, Ramonell RP, Dalton K, Ray P, Fahy JV, Seibold MA, Castro M, Jarjour N, Gaston B, Bleecker ER, Meyers DA, Moore W, Hastie AT, Israel E, Levy BD, Mauger D, Erzurum S, Comhair SA, Wenzel SE, Ray A. CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma. J Allergy Clin Immunol. 2023 Jul;152(1):94-106.e12. doi: 10.1016/j.jaci.2023.02.028. Epub 2023 Mar 8. PubMed PMID: 36893862; PubMed Central PMCID: PMC10330021.

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Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER. Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. Am J Respir Crit Care Med. 2023 Feb 15;207(4):438-451. doi: 10.1164/rccm.202206-1230OC. PubMed PMID: 36066606; PubMed Central PMCID: PMC9940145.

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Tattersall MC, Lee KE, Tsuchiya N, Osman F, Korcarz CE, Hansen KM, Peters MC, Fahy JV, Longhurst CA, Dunican E, Wentzel SE, Leader JK, Israel E, Levy BD, Castro M, Erzurum SC, Lempel J, Moore WC, Bleecker ER, Phillips BR, Mauger DT, Hoffman EA, Fain SB, Reeder SB, Sorkness RL, Jarjour NN, Denlinger LC, Schiebler ML. Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2023 Feb 15;207(4):475-484. doi: 10.1164/rccm.202203-0597OC. PubMed PMID: 36194556; PubMed Central PMCID: PMC9940151.

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Ginebaugh SP, Hagner M, Ray A, Erzurum SC, Comhair SAA, Denlinger LC, Jarjour NN, Castro M, Woodruff PG, Christenson SA, Bleecker ER, Meyers DA, Hastie AT, Moore WC, Mauger DT, Israel E, Levy BD, Wenzel SE, Camiolo MJ. Bronchial epithelial cell transcriptional responses to inhaled corticosteroids dictate severe asthmatic outcomes. J Allergy Clin Immunol. 2023 Jun;151(6):1513-1524. doi: 10.1016/j.jaci.2023.01.028. Epub 2023 Feb 14. PubMed PMID: 36796454; PubMed Central PMCID: PMC10257752.

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Ray A, Das J, Wenzel SE. Determining asthma endotypes and outcomes: Complementing existing clinical practice with modern machine learning. Cell Rep Med. 2022 Dec 20;3(12):100857. doi: 10.1016/j.xcrm.2022.100857. Review. PubMed PMID: 36543110; PubMed Central PMCID: PMC9798025.

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Peters MC, Schiebler ML, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Phillips BR, Mauger DT, Wenzel SE, Fajt ML, Koliwad SK, Denlinger LC, Woodruff PG, Jarjour NN, Fahy JV, National Heart . The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma. Am J Respir Crit Care Med. 2022 Nov 1;206(9):1096-1106. doi: 10.1164/rccm.202112-2745OC. PubMed PMID: 35687105; PubMed Central PMCID: PMC9704842.

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Schuyler AJ, Wenzel SE. Historical Redlining Impacts Contemporary Environmental and Asthma-related Outcomes in Black Adults. Am J Respir Crit Care Med. 2022 Oct 1;206(7):824-837. doi: 10.1164/rccm.202112-2707OC. PubMed PMID: 35612914; PubMed Central PMCID: PMC9799280.

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Wang Z, Xu W, Comhair SAA, Fu X, Shao Z, Bearden R, Zein JG, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Mauger DT, Gaston B, Hazen SL, Erzurum SC. Urinary total conjugated 3-bromotyrosine, asthma severity, and exacerbation risk. Am J Physiol Lung Cell Mol Physiol. 2022 Nov 1;323(5):L548-L557. doi: 10.1152/ajplung.00141.2022. Epub 2022 Sep 20. PubMed PMID: 36126269; PubMed Central PMCID: PMC9602918.

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Gaffin JM, Petty CR, Sorkness RL, Denlinger LC, Phillips BR, Ly NP, Gaston B, Ross K, Fitzpatrick A, Bacharier LB, DeBoer MD, Teague WG, Wenzel SE, Ramratnam S, Israel E, Mauger DT, Phipatanakul W, National Heart . Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3. J Allergy Clin Immunol. 2023 Jan;151(1):138-146.e9. doi: 10.1016/j.jaci.2022.08.014. Epub 2022 Aug 27. PubMed PMID: 36041656; PubMed Central PMCID: PMC9825637.

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Wang X, Xu Z, Hu H, Zhou X, Zhang Y, Lafyatis R, Chen K, Huang H, Ding Y, Duerr RH, Chen W. SECANT: a biology-guided semi-supervised method for clustering, classification, and annotation of single-cell multi-omics. PNAS Nexus. 2022 Sep;1(4):pgac165. doi: 10.1093/pnasnexus/pgac165. eCollection 2022 Sep. PubMed PMID: 36157595; PubMed Central PMCID: PMC9491696.

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Xu Z, Wang X, Fan L, Wang F, Lin B, Wang J, Trevejo-Nuñez G, Chen W, Chen K. Integrative analysis of spatial transcriptome with single-cell transcriptome and single-cell epigenome in mouse lungs after immunization. iScience. 2022 Sep 16;25(9):104900. doi: 10.1016/j.isci.2022.104900. eCollection 2022 Sep 16. PubMed PMID: 36039299; PubMed Central PMCID: PMC9418911.

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Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ, Dick TP, Finkel T, Forman HJ, Janssen-Heininger Y, Gems D, Kagan VE, Kalyanaraman B, Larsson NG, Milne GL, Nyström T, Poulsen HE, Radi R, Van Remmen H, Schumacker PT, Thornalley PJ, Toyokuni S, Winterbourn CC, Yin H, Halliwell B. Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nat Metab. 2022 Jun;4(6):651-662. doi: 10.1038/s42255-022-00591-z. Epub 2022 Jun 27. Review. PubMed PMID: 35760871; PubMed Central PMCID: PMC9711940.

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Izquierdo ME, Marion CR, Moore WC, Raraigh KS, Taylor-Cousar JL, Cutting GR, Ampleford E, Hawkins GA, Zein J, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Mauger D, Levy BD, Wenzel SE, Woodruff P, Bleecker ER, Meyers DA, Ortega VE. DNA sequencing analysis of cystic fibrosis transmembrane conductance regulator gene identifies cystic fibrosis-associated variants in the Severe Asthma Research Program. Pediatr Pulmonol. 2022 Jul;57(7):1782-1788. doi: 10.1002/ppul.25939. Epub 2022 May 5. PubMed PMID: 35451201; PubMed Central PMCID: PMC9443928.

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Tang M, Elicker BM, Henry T, Gierada DS, Schiebler ML, Huang BK, Peters MC, Castro M, Hoffman EA, Fain SB, Ash SY, Choi J, Hall C, Phillips BR, Mauger DT, Denlinger LC, Jarjour NN, Israel E, Phipatanakul W, Levy BD, Wenzel SE, Bleecker ER, Woodruff PG, Fahy JV, Dunican EM. Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time. Am J Respir Crit Care Med. 2022 May 1;205(9):1036-1045. doi: 10.1164/rccm.202110-2265OC. PubMed PMID: 35104436; PubMed Central PMCID: PMC9851493.

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Trivedi AP, Hall C, Goss CW, Lew D, Krings JG, McGregor MC, Samant M, Sieren JP, Li H, Schechtman KB, Schirm J, McEleney S, Peterson S, Moore WC, Bleecker ER, Meyers DA, Israel E, Washko GR, Levy BD, Leader JK, Wenzel SE, Fahy JV, Schiebler ML, Fain SB, Jarjour NN, Mauger DT, Reinhardt JM, Newell JD Jr, Hoffman EA, Castro M, Sheshadri A, NHLBI Severe Asthma Research Program (SARP). Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts. Radiology. 2022 Aug;304(2):450-459. doi: 10.1148/radiol.210363. Epub 2022 Apr 26. PubMed PMID: 35471111; PubMed Central PMCID: PMC9340243.

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Cardet JC, Kim D, Bleecker ER, Casale TB, Israel E, Mauger D, Meyers DA, Ampleford E, Hawkins GA, Tu Y, Liggett SB, Ortega VE, SARP3 investigators. Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma. J Allergy Clin Immunol. 2022 Sep;150(3):721-726.e1. doi: 10.1016/j.jaci.2022.03.024. Epub 2022 Apr 8. PubMed PMID: 35398411; PubMed Central PMCID: PMC9642856.

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Cagnina RE, Duvall MG, Nijmeh J, Levy BD. Specialized pro-resolving mediators in respiratory diseases. Curr Opin Clin Nutr Metab Care. 2022 Mar 1;25(2):67-74. doi: 10.1097/MCO.0000000000000805. Review. PubMed PMID: 34954726; PubMed Central PMCID: PMC8883347.

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Hamsanathan S, Anthonymuthu T, Han S, Shinglot H, Siefken E, Sims A, Sen P, Pepper HL, Snyder NW, Bayir H, Kagan V, Gurkar AU. Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60. Sci Adv. 2022 Feb 18;8(7):eabl6083. doi: 10.1126/sciadv.abl6083. Epub 2022 Feb 16. PubMed PMID: 35171671; PubMed Central PMCID: PMC8849393.

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Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A, Tyurina YY, Kagan VE, Wenzel SE. 15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation. J Clin Invest. 2022 Jan 4;132(1). doi: 10.1172/JCI151685. PubMed PMID: 34762602; PubMed Central PMCID: PMC8718153.

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Mummy DG, Dunican EM, Carey KJ, Evans MD, Elicker BM, Newell JD Jr, Gierada DS, Nagle SK, Schiebler ML, Sorkness RL, Jarjour NN, Denlinger LC, Fahy JV, Fain SB. Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at (3)He MRI. Radiology. 2022 Apr;303(1):184-190. doi: 10.1148/radiol.2021204616. Epub 2021 Dec 21. PubMed PMID: 34931858; PubMed Central PMCID: PMC8962781.

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Dy ABC, Langlais PR, Barker NK, Addison KJ, Tanyaratsrisakul S, Boitano S, Christenson SA, Kraft M, Meyers D, Bleecker ER, Li X, Ledford JG. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Sci Rep. 2021 Dec 3;11(1):23392. doi: 10.1038/s41598-021-02869-w. PubMed PMID: 34862427; PubMed Central PMCID: PMC8642528.

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Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Crotty Alexander L, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P, PrecISE Study Team. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions. J Allergy Clin Immunol. 2022 Feb;149(2):488-516.e9. doi: 10.1016/j.jaci.2021.10.035. Epub 2021 Nov 29. Review. PubMed PMID: 34848210; PubMed Central PMCID: PMC8821377.

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Ortega VE, Daya M, Szefler SJ, Bleecker ER, Chinchilli VM, Phipatanakul W, Mauger D, Martinez FD, Herrera-Luis E, Pino-Yanes M, Hawkins GA, Ampleford EJ, Kunselman SJ, Cox C, Bacharier LB, Cabana MD, Cardet JC, Castro M, Denlinger LC, Eng C, Fitzpatrick AM, Holguin F, Hu D, Jackson DJ, Jarjour N, Kraft M, Krishnan JA, Lazarus SC, Lemanske RF Jr, Lima JJ, Lugogo N, Mak A, Moore WC, Naureckas ET, Peters SP, Pongracic JA, Sajuthi SP, Seibold MA, Smith LJ, Solway J, Sorkness CA, Wenzel S, White SR, Burchard EG, Barnes K, Meyers DA, Israel E, Wechsler ME, NHLBI AsthmaNet. Pharmacogenetic studies of long-acting beta agonist and inhaled corticosteroid responsiveness in randomised controlled trials of individuals of African descent with asthma. Lancet Child Adolesc Health. 2021 Dec;5(12):862-872. doi: 10.1016/S2352-4642(21)00268-6. Epub 2021 Nov 9. PubMed PMID: 34762840; PubMed Central PMCID: PMC8787857.

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Camiolo MJ, Zhou X, Wei Q, Trejo Bittar HE, Kaminski N, Ray A, Wenzel SE. Machine learning implicates the IL-18 signaling axis in severe asthma. JCI Insight. 2021 Nov 8;6(21). doi: 10.1172/jci.insight.149945. PubMed PMID: 34591794; PubMed Central PMCID: PMC8663569.